Hub : Genes

ZFAND3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0880	0.0330	2.6e-03	0.016	NA	0.007	NA	0.004	1.6e-02	NA	8.7e-02	NA	1.3e-01
2	GTEx	Cells Transformed fibroblasts	0.1240	0.0450	1.3e-03	0.006	NA	0.004	NA	0.008	1.1e-01	NA	1.6e-01	NA	7.8e-02
3	GTEx	Testis	0.1360	0.0550	4.6e-03	0.033	NA	0.044	NA	0.011	1.3e-02	NA	5.0e-03	NA	1.0e-01
4	YFS	Blood	0.0499	0.0137	1.7e-06	0.017	0.025	0.022	0.026	0.022	2.3e-06	1.2e-08	5.7e-08	4.4e-09	6.0e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.1	1.8	5.3	2.3	-0.1	0.3	1.4
Bipolar Disorder or Schizophrenia	1.0	2.5	8.5	2.9	-0.6	-0.7	0.9
Depressed Affect (Nagel 2018)	0.2	0.5	1.1	0.4	0.6	-0.6	1.1
Depression (Nagel 2018)	1.7	2.5	8.9	0.4	-0.5	-3.0	0.9
Intelligence (Savage-Jansen 2018)	1.4	4.3	16.6	0.6	-0.2	4.1	0.3
Neuroticism (Nagel 2018)	0.4	1.0	2.2	0.1	0.5	-1.2	1.5
Schizophrenia (2018)	0.5	1.1	3.6	1.9	-0.7	-0.7	0.0
Schizophrenia vs Biploar Disorder	1.4	1.9	3.6	1.7	0.9	-0.0	1.9
Worry (Nagel 2018)	0.2	0.4	0.7	0.7	-0.2	-0.7	0.8
Alzheimer’s Disease (in mother)	0.7	0.8	2.9	-0.1	-0.5	-1.7	0.4
Alzheimer’s Disease (in father)	0.3	0.3	1.2	-0.3	-0.0	1.1	-0.1
Alzheimer’s Disease (including proxy)	0.5	0.7	1.7	-0.8	-0.7	-1.3	-0.3
Crohns Disease (2017)	0.2	0.5	1.4	-0.1	0.7	-0.0	-1.2
Irritable Bowel Disease (IBD)	0.3	0.6	1.1	-0.8	0.7	0.3	-1.1
Ulcerative Colitis (UC)	0.3	0.6	1.7	-1.3	0.6	0.0	-0.5
Major Depression (MDD)	2.2	2.7	6.7	1.9	-0.5	-0.1	2.6
Reaction Time	2.3	4.4	8.6	-2.9	-0.6	-0.8	-2.9
Verbal and Numeric Reasoning (VNR)	1.3	3.2	12.2	0.5	0.5	3.5	0.5
Breast Cancer	1.0	2.3	7.2	0.6	-2.7	-0.8	-1.0
Ovarian Cancer	0.3	0.4	0.7	0.7	0.8	-0.2	0.7
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.1	0.2	0.4	-0.6	-0.6	0.2	0.2
Bipolar Disorder (2011)	1.7	1.6	3.9	1.4	0.8	-0.1	2.0
Body Mass Index (BMI) (2010)	0.2	0.3	1.0	-0.0	0.3	1.0	-0.4
Coronary Artery Disease (CAD)	1.0	1.2	4.4	0.1	-0.4	2.1	0.3
Crohns Disease (2012)	0.2	0.3	0.8	0.3	0.7	0.0	-0.9
Mean Putamen Volume	0.5	0.6	1.6	-0.3	1.3	0.8	-0.1
Fasting Glucose	0.8	0.9	2.1	-0.6	1.1	0.2	1.4
HbA1C	1.3	1.4	2.9	1.5	-0.8	-0.1	1.7
HDL Cholesterol	1.3	2.1	3.3	-1.8	1.7	-0.7	-1.4
LDL Cholesterol	0.6	1.0	1.9	1.3	-1.4	-0.1	0.3
Lupus	0.6	0.8	2.3	0.6	-0.4	1.5	-0.8
Neuroticism (2016)	1.0	1.4	3.6	0.0	1.9	-0.8	1.2
Primary Biliary Cirrhosis	1.1	1.6	3.1	1.8	-0.3	0.7	1.6
Rheumatoid Arthritis	0.7	0.9	1.7	-0.9	-0.7	-0.8	-1.3
Schizophrenia (2014)	0.9	1.9	6.5	2.5	-0.4	-0.7	0.7
Triglycerides	1.1	1.8	2.4	1.6	-1.3	1.5	0.9
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.9	0.7	0.7	-1.4	0.4
Ulcerative Colitis	0.4	0.6	1.1	-0.9	1.0	-0.4	-0.7
Blood Eosinophil Count	0.3	2.7	5.7	1.3	1.2	1.4	2.4
Blood Platelet Count	0.7	8.7	17.0	4.1	1.6	3.4	1.8
Blood Red Count	1.2	11.3	22.4	4.7	-1.2	0.5	4.6
Blood White Count	0.4	3.1	8.2	2.9	-1.0	0.2	1.8
Heel T-Score	0.2	1.7	3.4	-0.6	-1.8	-0.0	-1.7
BMI	0.8	4.6	8.8	1.6	0.9	3.0	2.5
Height	0.2	3.6	13.0	-3.6	-0.6	0.8	-0.7
Waist Hip Ratio (WHR)	0.4	1.8	3.7	1.9	0.4	-1.2	1.4
Systolic Blood Pressure	0.7	3.6	8.9	3.0	0.1	-0.3	2.3
Smoking Status	0.6	1.5	3.2	-1.8	-1.6	0.0	0.6
Allergy or Eczema	0.2	0.5	0.9	-0.9	-1.0	-0.2	-0.5
Cardiovascular Disease	2.3	7.7	19.8	4.5	1.3	1.6	2.6
Hypothyroidism (self reported)	0.1	0.2	0.6	0.4	-0.8	-0.3	0.1
Respiratory disease	0.5	1.0	1.2	1.1	-0.9	-1.0	1.0
Type 2 Diabetes (T2D) (2018)	2.3	4.3	11.8	2.2	0.5	0.7	3.4
Lung FEV1/FVC ratio	0.4	2.2	4.3	2.1	-1.3	1.2	1.2
Lung FVC	0.6	2.9	4.7	-1.8	-1.9	0.3	-2.2
Neuroticism	0.5	1.1	2.0	0.4	1.0	-1.4	1.1
Chronotype (morning person)	0.3	0.7	1.1	-1.0	-0.4	1.1	-0.6
Hair Pigment	0.1	1.7	4.5	1.4	0.6	-0.2	2.1
Tanning	0.1	1.1	2.6	-1.3	-0.3	-1.6	0.1
Hand grip strength (left)	0.6	1.6	3.7	0.6	-1.4	1.9	-0.6
Number of treatments/medications taken	1.0	1.8	4.5	1.2	1.0	0.7	2.1
Average weekly spirits intake	0.9	1.1	3.2	-1.8	-1.1	0.4	-0.1
Sensitivity / hurt feelings	0.2	0.4	1.4	-0.4	-1.2	-0.3	0.2
Frequency of depressed mood in last 2 weeks	1.3	1.8	4.2	0.1	-0.9	-2.0	1.5
Hearing difficulty/problems: Yes	1.0	1.6	4.2	1.2	-0.7	-0.3	2.0
Relative age of first facial hair	0.8	1.6	3.7	1.4	0.6	1.9	0.6
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.7	-1.1	-0.2	-0.2	-1.3
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.9	-1.4	-0.4	-0.8	-0.0
Ever had hysterectomy (womb removed)	0.7	0.8	1.7	-0.7	-1.3	-0.9	-0.5
Systolic blood pressure, automated reading	1.2	3.4	6.6	2.2	-0.5	1.3	2.6
Eye problems/disorders: Diabetes related eye disease	0.9	0.9	2.8	1.7	-0.4	-0.5	0.8
Angina	5.3	6.9	13.4	3.7	-0.5	1.2	3.6
Medication for hormone replacement therapy	1.6	1.8	4.0	-1.3	1.1	-2.0	-0.0
Vitamin and mineral supplements	1.7	2.3	4.5	2.1	-0.5	1.1	1.8
Supplements: Zinc	0.3	0.3	0.8	-0.1	-0.9	0.3	0.4
Medication: Co-codamol	1.4	1.6	3.3	-0.8	-0.9	-1.8	-1.3
Medication: Metformin	2.3	3.2	5.8	1.9	1.0	1.6	2.4
Diabetes (father)	0.9	1.1	3.3	0.5	-1.8	-0.9	0.1
Diabetes (mother)	0.5	0.7	1.5	1.0	-1.2	-0.3	-0.0
Severe depression (siblings)	1.9	2.2	4.9	-0.3	-1.7	-2.2	-1.0
Pack years adult smoking proportion	1.1	1.6	3.7	-0.3	1.9	-0.6	1.5
Impedance of leg (right)	1.5	7.4	12.5	-3.5	1.5	-3.0	-2.4
Leg fat-free mass (left)	0.5	2.7	7.7	1.0	-0.5	2.8	1.3
Trunk fat percentage	0.3	1.0	2.1	-0.3	0.7	1.2	1.5
Hand grip strength (right)	0.3	0.9	1.9	0.5	-1.1	1.4	-0.1
Townsend deprivation index at recruitment	0.2	0.2	0.8	0.1	0.2	0.1	0.9
Current tobacco smoking	1.3	2.1	5.3	-2.3	-0.4	-1.6	-0.4
Average weekly fortified wine intake	2.8	3.3	8.1	-2.0	0.3	-1.0	-2.8
Maternal smoking around birth	0.1	0.2	0.4	-0.4	-0.3	0.6	0.4
Fed-up feelings	0.7	1.2	4.1	-0.9	0.0	-2.0	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.1	5.3	0.3	0.6	-2.3	1.7
Relative age voice broke	0.8	1.3	3.4	0.7	1.0	1.8	0.5
Taking other prescription medications	0.9	1.3	3.5	0.8	0.8	0.8	1.9
Age when periods started (menarche)	1.9	4.5	8.5	-2.9	1.1	-2.8	-0.3
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	1.8	-0.1	-1.3	-1.2	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	3.0	1.2	-1.6	1.7	0.3
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.1	-0.3	-0.8	1.0	-0.2
Qualifications: CSEs or equivalent	0.5	0.7	1.4	-0.6	1.2	-0.9	0.6
Serious illness, injury or assault to yourself	0.4	0.5	0.9	-0.0	-1.0	-0.1	0.9
High blood pressure	1.2	3.3	12.2	3.5	0.1	0.2	1.0
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.6	-0.3	-0.8	0.8	-0.1
Multivitamins +/- minerals	3.1	4.0	8.4	-2.1	0.2	-1.7	-2.9
Stomach or abdominal pain in last month	0.1	0.1	0.2	-0.5	-0.3	-0.4	-0.2
Supplements: Glucosamine	1.1	1.5	2.6	0.5	1.2	1.6	1.2
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	4.0	-1.9	2.0	-0.3	-0.6
Medication: Atenolol	1.3	1.6	2.4	1.6	0.8	1.1	1.5
Medication: Levothyroxine sodium	0.2	0.3	1.1	0.1	-1.0	-0.3	-0.0
Sitting height	0.3	1.8	3.7	-0.8	-1.7	1.9	-0.0
Chronic bronchitis/emphysema (father)	1.2	1.4	2.8	1.1	-1.7	0.2	1.2
High blood pressure (mother)	1.1	1.5	3.1	1.6	-0.5	1.8	0.1
Body mass index (BMI)	1.2	5.1	8.3	2.4	0.2	2.6	2.9
Impedance of leg (left)	1.2	5.9	11.0	-3.3	1.0	-2.9	-1.8
Leg predicted mass (left)	0.5	2.6	7.8	1.0	-0.5	2.8	1.3
Trunk fat mass	0.3	1.5	3.1	0.0	0.3	1.8	1.6
Waist circumference	0.4	1.4	2.8	0.9	0.1	1.7	1.4
Number of incorrect matches in round	0.7	1.2	2.5	0.5	-1.6	-1.2	-0.8
Past tobacco smoking	0.3	0.6	1.3	-0.1	1.1	-0.2	-1.1
Alcohol usually taken with meals	2.2	3.6	12.0	1.4	-3.5	0.7	0.1
Nervous feelings	0.7	1.4	3.0	-1.0	-0.6	-1.7	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.1	0.3	-0.3	-1.0	1.0
Hearing difficulty/problems with background noise	0.5	0.8	1.7	1.2	-1.3	0.3	0.1
Hair/balding pattern: Pattern 2	0.9	1.1	2.6	0.8	1.6	1.1	0.4
Had menopause	0.6	0.8	2.1	-1.4	0.9	-0.1	0.5
Had other major operations	1.6	2.0	5.5	-1.2	2.3	0.9	-0.2
Forced vital capacity (FVC)	0.2	0.9	1.6	-1.3	-1.0	1.0	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.1	0.4	-0.9	1.1	0.2
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	2.3	1.2	-1.0	1.0	1.5
Qualifications: None of the above	0.6	1.4	3.8	0.1	-0.5	-1.9	1.2
Financial difficulties in last 2 years	1.3	1.7	2.6	1.3	-0.2	-1.6	1.6
Mouth/teeth dental problems	1.9	2.9	3.8	1.6	1.4	1.8	1.9
Heart attack	0.3	0.4	1.4	-0.3	-0.1	-1.2	0.4
Allergy	0.2	0.4	1.2	0.2	1.1	-0.6	-0.1
Pain all over the body in last month	0.9	0.9	1.9	0.5	1.4	-1.3	0.1
Diabetes (self-reported)	2.6	3.9	8.6	2.1	1.1	1.2	2.9
Hayfever/allergic rhinitis (self-reported)	2.5	3.3	4.3	1.1	2.0	1.9	2.1
Medication: Ramipril	0.5	0.7	2.3	1.5	-0.4	-0.3	0.4
Medication: Simvastatin	2.2	3.2	8.8	3.0	-0.6	1.1	1.6
Fluid intelligence score	0.9	1.9	6.4	-0.4	0.9	2.5	0.5
Illnesses of siblings	1.6	2.3	4.5	-2.1	0.1	-0.9	-1.9
Neuroticism score	0.4	0.9	1.8	0.7	0.4	-1.3	1.0
Weight	0.6	2.8	7.0	0.8	-0.3	2.6	1.9
Impedance of arm (right)	1.2	5.6	7.9	-2.8	1.8	-2.0	-2.7
Arm fat percentage (right)	0.7	2.8	5.2	1.4	1.1	1.7	2.3
Trunk fat-free mass	0.4	2.3	6.9	0.8	-1.0	2.6	0.8
Hip circumference	0.3	1.3	4.2	-0.6	0.1	2.0	0.9
Time employed in main current job	0.9	1.1	3.3	-0.2	-1.8	-0.7	0.6
Alcohol intake versus 10 years previously	1.1	1.6	3.9	1.3	0.5	0.8	2.0
Father’s age at death	1.4	1.9	3.7	-0.6	-1.9	1.0	-1.5
Worrier / anxious feelings	1.0	1.9	3.5	1.9	-0.5	-0.9	1.8
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	4.8	-0.7	-0.2	-2.2	-0.6
Falls in the last year	0.4	0.6	0.8	0.9	-0.8	-0.8	0.5
Hair/balding pattern: Pattern 3	1.1	1.6	3.1	0.9	-1.3	1.8	0.9
Number of live births	0.6	0.9	2.3	-1.1	1.5	0.1	-0.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.5	-0.3	-1.1	1.2	0.2
Pulse rate	0.3	0.5	1.1	1.0	-0.9	0.1	0.2
Happiness	1.3	1.6	2.6	-1.5	-0.4	-1.6	-1.2
Noisy workplace	0.3	0.3	1.3	-1.1	0.0	-0.1	-0.2
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.5	0.0	-0.6	-0.1	-1.2
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.6	0.7	0.6	0.8	1.3
Mouth/teeth dental problems: Dentures	0.2	0.4	0.8	-0.9	-0.6	0.1	-0.6
Asthma	0.1	0.3	0.4	0.5	-0.6	-0.6	0.4
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	4.1	-2.0	0.1	-0.2	-1.8
Medication: Cholesterol lowering	0.7	1.0	2.6	1.6	-1.1	0.6	0.2
Depression (self-reported)	1.5	1.8	5.1	0.3	-2.3	1.3	0.6
Medication: Lansoprazole	0.4	0.5	1.5	1.2	0.3	0.2	0.6
Prospective memory result	0.4	0.4	0.9	-0.8	0.2	-0.9	-0.5
Lung cancer (father)	0.6	0.8	1.4	-0.8	-0.7	-1.2	0.7
Illnesses of mother	0.3	0.4	0.9	-0.5	0.9	0.2	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	1.5	-0.9	-1.1	1.2	-0.5
Pulse wave Arterial Stiffness index	0.3	0.4	0.9	0.7	0.0	0.3	0.9
Impedance of arm (left)	1.6	7.5	12.7	-3.6	1.6	-2.5	-2.9
Arm fat mass (right)	0.8	3.3	6.4	1.3	0.4	2.2	2.5
Trunk predicted mass	0.4	2.1	6.7	0.7	-1.0	2.6	0.7
Standing height	0.3	3.2	8.8	-3.0	-0.8	0.7	-1.7
Length of working week for main job	0.6	0.6	1.2	-1.1	-0.9	0.6	-0.5
Exposure to tobacco smoke at home	0.3	0.3	0.5	-0.5	-0.2	0.7	0.7
Breastfed as a baby	0.3	0.4	1.6	0.2	1.3	-0.0	-0.2
Tense / ‘highly strung’	1.9	3.2	9.4	-1.4	1.0	-3.1	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.1	3.1	6.1	1.6	-2.0	-0.2	2.5
Hair/balding pattern: Pattern 4	4.9	11.9	28.1	-5.3	-0.6	-3.5	-2.6
Birth weight of first child	1.3	2.4	3.7	1.8	-1.9	-1.3	1.0
Peak expiratory flow (PEF)	0.6	1.5	4.0	0.4	-2.0	1.3	-0.1
Pulse wave reflection index	0.3	0.4	1.1	0.4	-1.1	0.2	0.4
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.3	0.2	1.5	0.5	1.3
Loud music exposure frequency	0.7	0.7	2.3	-0.1	1.5	-0.7	-0.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.3	0.7	-1.1	-0.2	-1.0
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	1.9	-0.2	-1.2	-1.4	-1.3
Blood clot in the leg (DVT)	0.4	0.5	1.1	0.6	-1.0	0.7	0.3
Medication: Paracetamol	1.5	2.5	6.6	-2.6	-0.3	-0.9	-1.6
Headache pain in last month	0.1	0.2	0.6	0.8	0.3	-0.4	0.3
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	6.3	-2.5	0.8	-1.0	-0.8
Glaucoma (self-reported)	0.7	0.9	1.7	-0.5	-1.3	1.0	0.7
Gout (self-reported)	0.4	0.6	1.2	-0.7	-1.1	-0.8	-0.3
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	2.3	-0.4	-1.5	-0.6	-0.8
Medication: Amlodipine	0.7	0.9	2.4	1.5	0.2	0.8	-0.8
Medication: Ventolin 100micrograms inhaler	2.4	3.1	6.4	2.4	-0.1	0.3	2.5
Birth weight	3.1	6.7	11.3	2.5	0.3	3.4	3.0
Chronic bronchitis/emphysema (mother)	0.5	0.6	0.9	-0.6	-0.9	-0.9	-0.5
High blood pressure (siblings)	0.8	1.2	2.9	1.1	0.6	1.7	0.4
Forced vital capacity (FVC), Best measure	0.5	1.9	4.6	-2.1	-1.1	0.7	-1.0
Body fat percentage	0.4	1.6	3.6	0.3	0.9	1.3	1.9
Leg fat percentage (right)	0.4	1.3	2.6	0.3	1.1	1.1	1.6
Arm fat-free mass (right)	0.5	2.4	5.5	0.5	-1.0	2.3	1.6
Exposure to tobacco smoke outside home	3.7	5.0	10.8	-2.6	1.2	-3.3	-0.9
Comparative body size at age 10	2.3	6.2	14.7	3.8	-0.7	1.1	2.9
Number of full brothers	1.2	1.5	3.5	1.9	-1.2	-0.5	0.9
Worry too long after embarrassment	0.9	1.5	2.4	1.2	1.4	-0.7	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	3.5	-0.2	-1.9	0.3	-0.2
Wheeze or whistling in the chest in last year	0.2	0.3	0.5	0.5	-0.7	-0.6	0.3
Number of children fathered	0.3	0.3	0.6	0.8	0.4	-0.1	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	4.5	1.1	0.7	2.1	0.1
Age at first live birth	0.8	1.3	3.9	0.1	-0.4	1.2	-2.0
Pulse wave peak to peak time	0.4	0.4	1.0	-0.8	-0.2	-0.4	-1.0
Health satisfaction	0.4	0.5	1.3	0.1	1.1	0.2	0.7
Shortness of breath walking on level ground	1.4	1.7	5.8	0.2	0.7	0.5	2.4
Qualifications: College or University degree	1.2	3.9	7.1	0.8	-1.5	2.7	-2.4
Eye problems/disorders: None of the above	1.6	1.8	3.0	-0.4	1.7	-1.5	-1.3
Mouth/teeth dental problems: Loose teeth	0.8	1.0	3.2	0.7	-1.8	-0.5	-0.4
Emphysema/chronic bronchitis	0.6	0.6	1.3	0.2	-1.1	-1.1	0.1
Medication for pain relief, constipation, heartburn	0.9	1.5	3.2	1.5	-0.1	0.6	1.8
Neck or shoulder pain in last month	0.4	0.5	1.5	-1.2	0.7	-0.1	-0.4
Medication: Blood pressure	1.4	2.5	8.5	2.9	-0.6	1.1	-0.4
Angina (self-reported)	5.4	7.1	14.7	3.8	-0.8	1.0	3.5
Migraine (self-reported)	0.6	0.7	2.1	0.6	0.1	1.4	0.6
Medication: Ibuprofen	0.6	0.8	1.6	-1.3	-0.3	0.6	-1.0
Medication: Allopurinol	1.0	1.4	2.9	-0.6	-1.7	-1.4	-0.2
Medication: Omeprazole	4.4	5.3	11.4	-2.7	0.6	-1.5	-3.4
Medication: Seretide 50 evohaler	1.3	1.5	2.3	-1.2	0.5	-1.5	-1.4
Mean time to correctly identify matches	2.0	3.9	6.8	-2.4	-0.7	-1.6	-2.6
Heart disease (mother)	1.0	1.2	1.7	0.1	-1.3	-1.2	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.5	-0.7	1.2	-0.8	-1.1
Whole body fat mass	0.6	2.4	4.8	0.7	0.4	2.0	2.2
Leg fat mass (right)	0.6	2.4	5.1	1.0	0.5	1.8	2.2
Arm predicted mass (right)	0.4	2.2	5.4	0.3	-1.1	2.3	1.5
Pulse rate, automated reading	0.4	1.3	2.6	1.6	-1.2	0.7	0.8
Alcohol intake frequency.	0.6	1.3	4.5	-0.5	0.6	-2.1	0.3
Comparative height size at age 10	0.2	1.2	2.3	-1.3	-0.8	1.5	0.3
Number of full sisters	0.1	0.1	0.2	0.5	0.4	0.1	0.2
Suffer from ‘nerves’	0.4	0.6	0.9	-0.5	-1.0	-0.9	0.5
Overall health rating	0.1	0.3	0.7	0.4	0.5	-0.3	0.8
Chest pain or discomfort	0.3	0.4	1.2	0.4	-1.1	0.5	0.1
Had major operations	0.2	0.2	0.4	0.6	0.3	0.6	0.1
Age at last live birth	1.3	1.9	6.9	-0.7	0.3	0.5	-2.6
Family relationship satisfaction	0.7	0.8	3.0	-1.7	0.4	-0.3	-0.4
Leg pain on walking	0.3	0.4	0.6	0.8	0.6	0.7	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.5	2.1	-0.1	-0.0	-1.4	-0.3
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.0	1.0	0.7	-0.0	-0.1
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.8	-0.8	1.0	-0.2	-1.3
Medication: Aspirin	1.2	1.5	3.3	1.8	-0.1	1.5	0.8
Supplements: Vitamin C	0.6	0.7	1.9	-1.0	0.1	-0.3	-1.4
Knee pain experienced in last month	0.5	0.8	1.9	-0.3	0.9	-0.5	1.4
Hypertension (Self-reported)	1.4	4.0	14.4	3.8	-0.0	0.5	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	5.7	-1.2	-0.3	-0.4	-2.4
Illnesses of father: Heart disease	0.3	0.3	0.8	0.5	-0.5	0.9	-0.3
Illnesses of siblings: Diabetes	1.0	1.2	3.8	0.4	-0.3	-1.9	0.9
Smoking status: Previous	0.7	1.0	1.5	0.9	-1.2	0.8	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.7	-1.3	-0.5	0.7	0.2
Whole body fat-free mass	0.5	2.7	7.5	1.0	-0.8	2.7	1.2
Leg fat-free mass (right)	0.6	3.1	8.6	1.2	-0.8	2.9	1.4
Arm fat percentage (left)	0.5	2.2	4.5	1.0	0.9	1.6	2.1
Average weekly red wine intake	1.3	1.9	5.4	1.3	-0.5	-0.2	2.3
Handedness (chirality/laterality): Left-handed	2.1	2.5	5.8	-1.8	0.1	-1.1	-2.4
Mood swings	0.9	1.6	3.3	0.7	1.8	-0.5	1.6
Loneliness, isolation	0.3	0.4	0.9	0.2	-1.0	-0.7	0.1
Long-standing illness, disability or infirmity	1.7	2.5	4.4	1.7	-0.9	1.3	2.1
Ever had bowel cancer screening	0.6	0.7	1.7	-0.2	1.3	-0.8	-0.7
Diabetes diagnosed by doctor	1.7	2.9	6.6	1.9	1.0	0.3	2.6
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.3	1.1	-0.2	0.1	0.0
Friendships satisfaction	0.2	0.2	0.5	-0.7	0.4	-0.6	0.0
Qualifications: nursing, teaching	0.4	0.7	1.3	1.1	0.5	1.0	-0.0
Commuting to job workplace: Walk	1.0	1.0	3.7	-1.9	0.4	-0.5	-0.2
Eye problems/disorders: Cataract	2.0	2.3	5.6	0.4	-0.0	1.9	2.4
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	2.8	-1.6	0.4	-1.7	-1.4
Medication for cholesterol	2.3	3.4	5.5	-1.9	-2.3	0.6	-2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.7	0.6	0.1	0.2	0.8
Back pain experienced in last month	0.2	0.2	0.4	-0.5	0.0	0.5	-0.6
Mineral and other dietary supplements	0.4	0.5	1.1	0.3	0.1	-1.1	0.9
Breast cancer (self-reported)	0.4	0.4	0.7	-0.7	0.9	0.1	0.7
Asthma (self-reported)	0.2	0.4	0.7	0.6	-0.4	-0.8	0.7
Osteoporosis (self-reported)	0.3	0.4	0.7	0.6	-0.4	-0.8	-0.6
Osteoarthritis (self-reported)	0.1	0.2	0.3	-0.6	-0.4	0.5	0.2
Medication: Aspirin	1.3	1.6	3.2	1.8	0.1	1.5	1.1
Medication: Gliclazide	2.3	2.6	4.7	1.7	1.6	0.6	2.2
Illnesses of father: None of the above (group 1)	2.2	2.7	5.5	-2.3	2.2	-0.5	-0.4
Smoking status: Current	1.5	2.3	5.7	-2.4	-0.8	-1.6	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	2.9	-1.7	-0.8	1.1	-1.1
Whole body water mass	0.5	2.8	8.1	1.0	-0.9	2.8	1.3
Leg predicted mass (right)	0.6	3.0	8.2	1.1	-0.8	2.9	1.3
Arm fat mass (left)	0.7	3.0	6.1	1.2	0.3	2.1	2.5
Number of self-reported non-cancer illnesses	0.2	0.3	1.0	1.0	-0.2	0.6	0.0
Average weekly champagne plus white wine intake	1.7	2.3	3.3	1.8	-0.3	1.7	1.8
Miserableness	0.8	1.3	3.6	1.3	-0.1	-0.1	1.9
Guilty feelings	1.3	1.9	5.3	1.4	-0.1	-0.6	2.3
Wears glasses or contact lenses	1.2	1.4	4.5	0.4	-0.8	2.1	-0.4
Ever taken oral contraceptive pill	0.4	0.4	1.0	-0.8	1.0	-0.1	0.2
Hearing aid user	0.2	0.2	0.4	-0.2	0.6	0.3	0.7
Mother’s age at death	0.9	1.1	2.6	-0.4	-0.2	1.6	-1.2
Financial situation satisfaction	0.9	1.1	2.3	-0.0	1.1	-1.5	0.9
Tinnitus: Yes, now most or all of the time	1.7	2.0	3.5	1.9	-1.0	1.2	1.5
Commuting to job workplace: Public transport	0.4	0.5	1.3	0.3	-1.2	0.4	0.7
Eye problems/disorders: Glaucoma	0.7	0.8	1.1	-0.3	-1.0	1.1	0.9
Medication: Blood pressure	1.3	2.4	4.1	2.0	1.2	0.1	2.0
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.9	-0.7	-1.0	0.4	-0.5
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.3	-1.1	-0.1	0.1	-1.5
High cholesterol (Self-reported)	1.1	1.9	6.0	2.5	0.0	1.0	0.9
Medication: Bendroflumethiazide	2.0	3.0	10.0	3.2	-0.3	0.9	1.1
Medication: Paracetamol	1.9	3.0	7.9	-2.8	-0.7	-0.9	-1.6
Medication: Lisinopril	1.1	1.4	2.3	1.5	1.3	0.4	1.2
Medication: Atorvastatin	0.9	1.1	1.9	0.8	1.4	-0.0	1.3
Illnesses of father: High blood pressure	0.8	1.0	2.7	1.6	-0.3	1.1	0.0
Alcohol drinker status: Never	0.5	0.6	1.3	0.9	-1.1	-0.1	0.5
Ever smoked	0.4	0.7	1.8	0.1	-1.4	-0.0	0.9
Basal metabolic rate	0.5	2.8	7.6	1.0	-0.7	2.8	1.5
Leg fat percentage (left)	0.5	1.7	4.4	0.7	0.5	1.4	2.1
Arm fat-free mass (left)	0.6	2.9	6.7	1.0	-1.1	2.6	1.6
Number of operations (self-reported)	1.7	2.5	5.0	-2.2	2.2	0.3	-0.6
Average weekly beer plus cider intake	1.6	2.3	4.5	-0.9	2.0	0.3	-2.1
Irritability	1.2	1.9	5.7	-1.3	0.3	-2.4	0.6
Risk taking	1.6	2.3	6.9	0.9	2.6	0.6	1.1
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.5	-0.2	-0.5	-0.6	-0.7
Fractured/broken bones in last 5 years	1.0	1.3	2.0	0.9	1.1	-1.1	1.4
Age started oral contraceptive pill	0.7	0.8	1.7	-0.0	-0.7	1.3	-1.1
Diastolic blood pressure, automated reading	1.1	3.3	7.4	2.0	0.6	1.3	2.7
Ever depressed for a whole week	1.3	1.6	3.6	1.4	-0.5	0.7	1.9
Unable to work because of sickness or disability	0.2	0.3	0.5	-0.0	0.7	-0.6	0.5
Commuting to job workplace: Cycle	0.8	0.9	1.9	1.4	-1.0	0.8	0.1
Myopia	1.7	2.5	4.1	1.8	1.4	0.7	2.0
Vascular/heart problems diagnosed by doctor	1.5	4.1	13.8	-3.7	-0.0	-0.1	-1.6
Cholesterol lowering medication	1.0	1.4	1.9	1.4	1.4	-0.6	1.2
Medication: Omeprazole (e.g. Zanprol)	5.3	6.5	11.6	-2.9	1.5	-1.9	-3.4
Pain experienced in last month	0.5	0.8	3.0	0.3	-1.7	-0.2	0.1
Supplements: Calcium	1.5	1.6	2.7	0.7	-1.6	0.8	1.6
Basal cell carcinoma (self-reported)	1.2	1.4	3.7	1.0	-1.9	0.5	0.8
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.2	-0.4	-0.1	-1.1	0.5
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.6	0.3	-1.3	0.9	-0.1
Heart disease (siblings)	0.4	0.5	1.1	-0.2	-0.8	-0.1	1.1
Alcohol drinker status: Previous	0.1	0.1	0.1	0.1	0.2	-0.3	0.3
Pack years of smoking	0.9	1.3	2.8	0.0	1.7	-0.4	1.5
Impedance of whole body	1.5	7.4	12.4	-3.5	1.1	-3.0	-2.6
Leg fat mass (left)	0.8	3.0	6.4	1.1	0.2	2.1	2.5
Arm predicted mass (left)	0.6	3.3	7.1	1.1	-1.0	2.7	1.9