TWAS hub - CD82

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.3340	0.0580	2.4e-07	0.172	0.074	0.199	0.217	0.214	1.8e-20	2.3e-09	1.1e-23	5.3e-26	1.5e-25
2	GTEx	Brain Cerebellar Hemisphere	0.4880	0.1410	2.7e-03	0.017	NA	-0.012	NA	0.076	1.2e-01	NA	9.2e-01	NA	5.3e-03
3	GTEx	Esophagus Mucosa	0.2080	0.0520	4.6e-05	0.221	NA	0.198	NA	0.213	7.6e-15	NA	2.6e-13	NA	2.8e-14
4	METSIM	Adipose	0.2753	0.0426	1.5e-11	0.080	0.085	0.115	0.145	0.129	5.6e-12	1.0e-12	7.8e-17	5.4e-21	1.1e-18
5	ROSMAP	Brain Pre-frontal Cortex	0.2994	0.0453	7.1e-10	0.159	0.139	0.206	0.213	0.202	6.9e-20	1.9e-17	5.9e-26	7.7e-27	2.2e-25
6	YFS	Blood	0.0457	0.0131	1.6e-05	0.003	0.019	0.016	0.019	0.012	2.0e-02	6.6e-07	4.5e-06	6.4e-07	5.1e-05
7	TCGA	Brain Lower Grade Glioma	0.0664	0.0270	2.7e-03	0.046	0.014	0.038	NA	0.032	5.5e-06	9.7e-03	3.7e-05	NA	1.2e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Emphysema/chronic bronchitis	3.8	4.3	13.9	-2.9	0.7	-0.3	-1.4	-1.9	-1.2	-3.7
Supplements: Zinc	3.4	3.7	16.3	0.1	-4.0	-1.6	0.2	-1.3	0.9	-2.0
Medication: Atorvastatin	3.4	4.2	7.7	-1.5	-0.6	-1.2	-2.4	-2.5	-2.4	-2.8
Number of full brothers	2.7	3.4	7.5	-1.7	1.9	1.1	2.7	-1.9	2.1	-0.7
Hair/balding pattern: Pattern 4	2.6	6.2	26.8	-0.4	-5.2	-3.4	-1.7	-1.2	0.5	-0.4
Eye problems/disorders: Cataract	2.5	2.9	5.9	-2.3	-0.2	1.5	2.2	-2.4	1.3	-0.5
Triglycerides	2.3	3.7	8.0	0.3	-1.8	-2.8	-2.6	-1.0	-2.7	-0.4
Hearing difficulty/problems with background noise	2.3	3.6	11.6	-3.0	0.0	-0.8	-0.8	-3.4	0.2	-1.8
Eye problems/disorders: None of the above	2.3	2.6	9.2	0.6	-0.3	-2.4	-3.0	0.9	-1.4	0.4
Prostate Cancer	2.1	2.9	7.8	0.8	0.6	-1.8	-2.8	1.2	-2.6	0.1
Schizophrenia (2014)	2.1	4.7	11.3	2.8	0.4	-1.1	1.8	2.3	2.0	3.4
Eye problems/disorders: Diabetes related eye disease	2.1	2.3	8.5	0.1	0.4	1.2	2.9	-0.3	2.0	1.3
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.2	5.0	-2.2	-1.8	-1.1	-0.5	-2.0	0.9	-1.1
Schizophrenia (2018)	2.0	4.1	9.3	2.7	0.5	-0.4	2.3	1.7	1.9	3.1
Depression (self-reported)	2.0	2.4	9.2	1.3	0.5	0.6	0.9	2.0	-0.2	3.0
Friendships satisfaction	1.9	2.4	6.2	2.5	-0.7	-1.3	1.1	0.8	1.5	2.1
Depression (Nagel 2018)	1.8	2.7	5.9	2.3	0.9	0.8	1.5	2.0	0.7	2.4
Number of live births	1.8	2.5	6.6	-2.6	-1.5	-0.5	-0.8	-2.5	0.2	-1.3
Medication: Allopurinol	1.8	2.4	8.0	-2.2	-0.7	-1.2	0.3	-2.8	0.1	-1.3
Frequency of depressed mood in last 2 weeks	1.7	2.4	6.4	2.5	0.3	0.3	0.3	2.0	0.0	2.5
Current tobacco smoking	1.6	2.6	5.8	1.4	-1.8	1.0	2.0	0.8	1.3	2.4
Fed-up feelings	1.6	2.9	8.6	1.0	0.7	-1.9	-2.0	0.7	-1.4	2.9
Health satisfaction	1.6	2.1	6.6	-0.4	0.4	1.5	2.6	-0.4	2.1	-0.9
Had major operations	1.6	1.8	3.9	0.1	0.7	1.4	2.0	-1.8	1.6	0.8
Miserableness	1.6	2.7	8.1	-2.2	1.1	-1.8	-1.1	-2.9	-0.6	0.4
Ever had prostate specific antigen (PSA) test	1.6	1.8	3.4	-1.8	1.6	1.2	-0.1	-1.6	0.1	-1.6
Hearing difficulty/problems: Yes	1.5	2.2	5.9	-2.0	0.2	-0.2	-0.2	-2.4	0.6	-2.3
Vitamin and mineral supplements	1.5	2.1	8.3	-1.4	2.9	-0.4	-1.4	-1.0	-1.0	-0.3
Bilateral oophorectomy (both ovaries removed)	1.5	1.8	5.1	-0.8	-2.3	-2.2	-0.7	-1.2	-0.1	0.1
Hair/balding pattern: Pattern 2	1.5	1.9	6.6	-0.9	2.6	-0.2	1.8	-0.7	1.2	0.6
Pain all over the body in last month	1.5	1.6	5.1	0.2	-0.5	0.7	2.1	-0.1	2.3	-0.9
Average weekly champagne plus white wine intake	1.5	2.1	5.8	-1.5	0.1	1.0	1.4	-1.6	1.2	-2.4
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	10.3	1.5	-0.0	-0.7	0.4	1.4	-0.4	3.2
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	5.8	-1.1	-0.8	0.7	1.7	-0.8	2.4	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	4.7	1.2	0.3	1.0	0.8	1.8	1.2	2.2
Heart disease (mother)	1.4	1.7	4.2	-0.2	-2.0	-0.0	-1.6	0.1	-1.6	-1.5
Smoking status: Current	1.4	2.3	5.8	1.4	-1.6	0.9	1.7	0.8	1.2	2.4
Bipolar Disorder or Schizophrenia	1.3	3.1	7.3	2.4	0.1	-0.2	1.7	1.8	1.5	2.7
Coronary Artery Disease (CAD)	1.3	1.6	3.0	-1.7	-0.5	1.6	1.0	-1.3	1.3	-0.9
HbA1C	1.3	1.4	6.4	2.5	0.1	0.2	-0.1	1.5	-0.3	1.0
Average weekly spirits intake	1.3	1.6	5.4	-1.4	-0.8	0.9	-0.1	-1.7	0.0	-2.3
Medication: Co-codamol	1.3	1.5	5.7	1.3	0.8	-0.6	-1.1	2.4	-0.8	-0.7
Multivitamins +/- minerals	1.3	1.7	8.8	-0.1	-3.0	0.8	1.2	-0.0	0.7	-0.7
Glaucoma (self-reported)	1.3	1.5	3.2	1.1	0.5	1.4	1.7	1.8	-0.6	0.9
Shortness of breath walking on level ground	1.3	1.5	3.3	-0.6	-0.5	1.8	1.8	-0.1	1.4	-1.2
Commuting to job workplace: Walk	1.3	1.4	4.1	1.3	-1.5	-2.0	-0.8	0.7	-0.5	0.4
Eye problems/disorders: Glaucoma	1.3	1.6	3.8	1.3	0.0	1.9	1.9	1.3	-0.7	0.2
Crohns Disease (2017)	1.2	2.7	5.7	-2.4	-0.9	1.4	1.8	-2.2	1.0	-1.0
Length of working week for main job	1.2	1.3	3.8	1.6	0.8	0.2	-0.1	1.3	-0.7	1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	5.5	0.8	-1.2	-2.1	-0.1	-0.1	0.4	2.3
Medication: Bendroflumethiazide	1.2	1.9	4.2	-2.1	-0.2	1.1	1.4	-1.9	0.2	-1.3
Basal cell carcinoma (self-reported)	1.2	1.4	4.2	0.3	0.5	1.2	2.1	0.5	1.3	1.4
Crohns Disease (2012)	1.1	1.8	4.4	-2.1	-0.4	0.9	1.4	-1.4	1.7	-0.6
Hand grip strength (left)	1.1	2.8	6.2	1.0	2.2	1.4	1.3	1.7	0.8	2.5
Ever had hysterectomy (womb removed)	1.1	1.2	3.3	-0.1	0.0	-1.8	-1.8	-0.7	-0.7	1.1
Qualifications: CSEs or equivalent	1.1	1.4	3.5	-1.0	0.5	1.6	0.9	-1.1	1.9	0.7
Medication: Atenolol	1.1	1.4	4.3	0.8	1.0	0.1	-2.1	1.3	-1.3	0.4
Fluid intelligence score	1.1	2.3	6.3	-1.2	-0.0	-2.0	-1.3	-1.1	-1.3	2.5
Loud music exposure frequency	1.1	1.2	3.7	-1.2	-0.2	1.9	1.1	-0.6	1.3	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	3.0	0.9	-0.9	-0.9	-1.5	1.7	-1.2	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.6	-1.3	-1.1	0.4	1.2	-1.1	1.9	-0.2
Loneliness, isolation	1.1	1.5	6.4	1.4	-0.3	-0.4	0.1	1.4	0.2	2.5
Breast cancer (self-reported)	1.1	1.3	3.7	-0.1	-0.3	-1.2	-1.9	0.7	-1.7	0.3
Alcohol drinker status: Never	1.1	1.3	3.0	1.7	-1.4	-1.4	0.1	-0.3	0.7	1.3
Blood Platelet Count	1.0	11.9	35.9	-1.5	0.5	5.4	6.0	-0.7	3.7	-1.5
Medication for hormone replacement therapy	1.0	1.2	2.1	1.4	-0.8	-1.4	0.6	1.0	0.4	1.5
Mouth/teeth dental problems	1.0	1.6	5.3	-2.3	0.9	-0.7	-0.1	-1.9	-1.1	0.2
Time employed in main current job	1.0	1.1	2.3	1.5	0.2	-0.6	-0.1	1.5	-1.1	1.2
Alcohol intake versus 10 years previously	1.0	1.5	4.5	0.7	-0.0	-1.5	-1.3	-0.3	-2.1	1.2
Hair/balding pattern: Pattern 3	1.0	1.4	6.6	0.2	-2.6	0.4	-0.6	0.5	1.1	-1.2
Happiness	1.0	1.2	3.6	-0.0	-1.4	-0.2	1.2	-1.1	1.9	0.3
Medication: Seretide 50 evohaler	1.0	1.2	2.5	-1.1	-1.0	-1.3	-0.8	0.5	-1.6	-0.9
Mood swings	1.0	1.7	4.2	2.0	1.0	-0.9	-0.5	1.3	-0.5	2.0
High cholesterol (Self-reported)	1.0	1.8	7.8	0.2	-0.5	0.1	-1.6	0.6	-2.8	-1.1
Irritability	1.0	1.7	4.4	2.1	0.8	-1.0	-0.6	2.1	0.2	1.1
Arm predicted mass (left)	1.0	5.2	18.1	-0.5	-1.1	1.8	4.3	-0.5	3.6	0.8
Type 2 Diabetes (T2D) (2012)	0.9	1.1	1.5	-1.2	1.1	-1.0	-1.2	-0.4	-0.9	-1.2
Severe depression (siblings)	0.9	1.0	1.7	1.3	1.0	-0.3	-0.1	1.3	-1.2	0.9
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	2.2	1.3	0.6	-0.0	1.1	1.5	-0.5	1.0
Had menopause	0.9	1.1	3.2	-0.7	1.2	0.1	1.8	-0.9	1.2	0.8
Heart attack	0.9	1.1	2.9	-0.3	0.1	1.5	-0.0	0.4	-1.7	-1.5
Father’s age at death	0.9	1.2	3.8	1.2	0.8	0.1	-2.0	1.2	-0.9	-0.3
Worrier / anxious feelings	0.9	1.7	4.1	1.8	-0.6	-1.0	1.0	1.6	-0.3	2.0
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	4.1	2.0	-0.1	-0.1	0.3	1.4	-0.5	2.0
Medication: Cholesterol lowering	0.9	1.4	3.3	1.1	-1.5	-0.4	-1.0	0.5	-1.8	-1.1
Exposure to tobacco smoke at home	0.9	1.0	5.1	0.6	-2.2	0.4	0.8	0.9	-0.1	-0.7
Birth weight of first child	0.9	1.6	3.6	-1.9	-1.3	1.0	0.8	-1.4	1.2	0.8
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	4.5	-1.9	2.1	-0.5	-0.2	-1.2	0.1	-0.4
Number of children fathered	0.9	1.1	3.2	-0.8	0.6	1.4	-0.8	-0.1	-0.8	-1.8
Supplements: Vitamin C	0.9	1.1	3.5	0.9	-1.9	-1.6	0.3	-0.0	0.4	0.8
Smoking status: Previous	0.9	1.4	6.9	-1.5	0.2	0.2	-0.5	0.3	0.6	-2.6
Medication: Paracetamol	0.9	1.4	2.9	-0.1	-1.6	0.2	1.4	-0.1	1.7	1.5
Illnesses of father: High blood pressure	0.9	1.1	4.5	0.9	2.1	-0.4	-1.2	0.4	-0.5	0.5
Arm fat-free mass (left)	0.9	4.8	16.4	0.0	-1.1	1.6	4.0	-0.0	3.4	1.3
Age at First Birth	0.8	1.2	3.2	-0.3	-1.8	-1.5	-0.5	-0.4	-0.9	1.4
Fasting Glucose	0.8	1.0	3.8	-0.7	-0.5	-0.3	-2.0	-0.7	-1.2	-0.3
LDL Cholesterol	0.8	1.3	3.7	-1.1	-0.7	-0.6	-0.5	-1.3	-1.0	-1.9
Relative age of first facial hair	0.8	1.6	6.1	1.0	1.0	0.2	-0.5	1.3	-1.0	2.5
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	3.2	-1.3	-1.0	-1.8	-0.4	-1.0	-0.5	0.2
Diabetes (father)	0.8	0.9	3.3	-0.1	-1.2	-0.2	1.1	-1.8	0.9	0.1
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	3.0	-1.0	1.3	0.5	-0.3	-0.7	-0.4	-1.7
Impedance of arm (left)	0.8	3.7	8.2	-0.2	2.1	-1.7	-2.9	-0.0	-2.9	-1.3
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	4.9	0.3	-1.0	-2.2	-1.5	-0.0	-1.7	0.5
Exposure to tobacco smoke outside home	0.8	1.1	1.8	0.4	-1.4	-1.2	-1.2	0.9	-0.6	1.2
Arm predicted mass (right)	0.8	4.2	14.8	0.1	-0.6	1.6	3.9	0.1	3.0	1.4
Commuting to job workplace: Car/motor vehicle	0.8	1.0	4.9	0.3	2.2	-1.3	0.0	-0.2	-0.3	-0.2
Handedness (chirality/laterality): Left-handed	0.8	1.0	4.4	-0.1	-0.6	-0.4	-0.9	1.0	-0.4	-2.1
Myopia	0.8	1.1	5.2	0.6	-1.3	0.6	-0.4	2.3	-0.6	-0.1
Heart attack/myocardial infarction (self-reported)	0.8	1.1	3.3	-0.2	0.2	1.2	-0.3	0.7	-1.8	-1.4
Depressed Affect (Nagel 2018)	0.7	1.4	5.2	1.1	1.3	-1.0	-0.2	0.7	-0.7	2.3
Intelligence (Savage-Jansen 2018)	0.7	2.1	8.4	-2.9	-0.1	-0.7	-0.8	-1.8	-0.6	1.2
Neuroticism (Nagel 2018)	0.7	1.7	7.8	1.3	1.2	-0.7	0.6	0.6	-0.4	2.8
Alzheimer’s Disease (in mother)	0.7	0.9	3.7	-0.6	0.7	-0.5	-0.4	-0.5	-0.8	-1.9
Alzheimer’s Disease (in father)	0.7	0.8	4.1	-0.6	-0.5	-2.0	-0.3	0.6	0.1	-0.7
Alzheimer’s Disease (including proxy)	0.7	1.0	2.3	-1.5	0.5	-1.1	-0.3	-0.9	0.3	-1.5
Hypothyroidism (self reported)	0.7	1.6	5.4	-0.6	-0.8	-1.4	-1.6	-0.7	-2.3	-0.6
Hand grip strength (right)	0.7	2.0	5.8	1.5	1.2	1.1	1.2	1.4	-0.2	2.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.1	0.9	1.1	0.4	0.6	1.0	0.7	1.5
Stomach or abdominal pain in last month	0.7	0.9	1.9	-1.0	-0.7	-0.9	0.6	-1.2	1.4	0.1
Medication: Levothyroxine sodium	0.7	1.1	3.3	-0.4	-0.3	-1.8	-1.3	-0.7	-1.3	0.5
Chronic bronchitis/emphysema (father)	0.7	0.8	2.2	-1.1	1.1	0.1	0.5	-1.5	0.3	-1.0
Nervous feelings	0.7	1.2	3.4	0.4	-1.0	-1.6	-1.2	0.4	-1.8	0.1
Financial difficulties in last 2 years	0.7	0.9	2.4	0.0	-1.4	-0.0	-0.1	1.6	-0.4	-1.4
Falls in the last year	0.7	1.0	2.1	1.1	-1.0	-0.7	0.8	1.4	0.2	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	4.5	-0.3	-2.1	-0.5	-0.8	-0.6	-0.3	0.6
Pulse wave reflection index	0.7	0.8	1.7	-0.7	0.6	1.3	-0.8	-0.5	-0.8	-1.3
Medication: Amlodipine	0.7	0.9	4.0	0.6	-0.9	-0.1	0.6	0.9	0.5	2.0
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.8	-1.7	-0.0	0.4	-0.6	-0.6	-1.1	-1.2
Arm fat-free mass (right)	0.7	3.4	12.0	0.1	-0.7	1.4	3.5	0.0	2.8	1.3
Medication: Ibuprofen	0.7	0.9	4.1	0.4	-2.0	-0.5	-0.5	-0.0	0.3	1.1
Family relationship satisfaction	0.7	0.8	2.5	1.6	-0.9	-0.8	-0.2	0.7	1.1	-0.0
Ever had bowel cancer screening	0.7	0.8	1.7	-0.9	-0.8	1.3	0.5	-0.9	1.1	-0.4
Whole body water mass	0.7	3.8	12.9	0.1	-0.6	1.6	3.6	0.3	2.9	1.6
Wears glasses or contact lenses	0.7	0.8	3.2	1.8	0.5	-0.4	-0.5	0.9	-0.8	0.6
Supplements: Fish oil (including cod liver oil)	0.7	0.9	4.9	0.6	-0.4	0.0	-0.2	-0.5	-0.8	-2.2
Basal metabolic rate	0.7	3.9	13.3	0.3	-0.3	1.7	3.6	0.6	2.9	1.4
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.6	-0.6	1.1	-0.1	0.7	-1.3	1.0	-1.1
Verbal and Numeric Reasoning (VNR)	0.6	1.5	6.2	-1.5	0.3	-0.9	-0.9	-0.5	-0.7	2.5
Bipolar Disorder (2011)	0.6	0.5	2.1	1.0	-1.5	-0.4	0.2	0.6	0.4	0.0
HDL Cholesterol	0.6	0.9	2.6	-0.2	0.9	1.3	1.1	0.4	1.6	-0.0
Primary Biliary Cirrhosis	0.6	0.8	2.5	1.2	-0.4	0.8	0.1	1.6	-0.9	0.4
Blood Red Count	0.6	5.3	18.6	-0.5	-0.6	-2.3	-3.1	-1.3	-4.3	-1.2
Sensitivity / hurt feelings	0.6	1.1	3.6	-0.7	1.9	-0.5	-0.1	-1.3	0.9	0.9
Angina	0.6	0.8	3.3	1.0	-0.0	1.8	0.8	0.7	-0.3	-0.5
Impedance of leg (right)	0.6	2.9	7.0	-1.2	-0.1	-1.0	-2.3	-1.0	-2.2	-2.6
Leg fat-free mass (left)	0.6	3.4	10.8	0.7	0.0	1.4	3.3	1.0	2.4	1.8
Average weekly fortified wine intake	0.6	0.7	2.8	0.4	-0.6	-0.1	-0.0	-1.7	-1.1	0.6
Relative age voice broke	0.6	1.0	3.3	-0.0	0.3	-1.2	-0.8	-0.2	-1.1	1.8
Impedance of leg (left)	0.6	3.1	6.8	-1.1	-0.0	-1.0	-2.6	-1.1	-2.3	-2.5
Leg predicted mass (left)	0.6	3.2	10.5	0.7	0.0	1.3	3.2	1.0	2.3	1.7
Past tobacco smoking	0.6	1.0	3.5	1.3	0.1	-0.4	-0.3	-0.2	-1.3	1.9
Illnesses of siblings	0.6	0.8	2.2	0.7	-1.5	-1.0	-0.7	1.1	0.4	0.4
Weight	0.6	2.9	11.4	0.2	-0.0	1.7	3.4	0.5	2.4	0.3
Trunk fat-free mass	0.6	3.5	11.4	0.0	-0.5	1.7	3.4	0.3	2.8	1.5
Trunk predicted mass	0.6	3.4	11.0	0.0	-0.5	1.6	3.3	0.4	2.8	1.5
Peak expiratory flow (PEF)	0.6	1.4	4.9	0.7	-0.4	-1.4	-1.5	0.1	0.4	2.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.1	0.3	1.4	0.7	-0.7	1.2	0.1	-1.0
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.9	0.6	1.4	-0.3	0.0	1.2	0.1	1.0
Worry too long after embarrassment	0.6	1.1	3.4	-0.9	0.7	-0.8	-1.1	-1.8	-0.8	0.3
Mouth/teeth dental problems: Loose teeth	0.6	0.8	2.3	0.8	-1.5	-0.6	0.7	0.3	1.1	0.6
Migraine (self-reported)	0.6	0.7	2.3	-0.0	-0.1	-0.5	-1.5	0.7	-0.7	1.2
Medication: Omeprazole	0.6	0.8	1.6	-0.0	1.2	0.6	1.2	-0.8	0.7	-0.9
Leg fat mass (right)	0.6	2.3	9.0	-0.0	-0.7	1.5	3.0	0.5	2.0	-0.6
Number of full sisters	0.6	0.7	1.9	-0.7	-1.4	-0.2	-1.4	-0.5	-0.6	0.1
Age at last live birth	0.6	0.8	2.8	0.6	-0.3	-1.4	-0.5	-0.6	-0.4	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.4	-1.2	0.2	0.7	0.4	-0.7	0.0	-1.6
Illnesses of father: Heart disease	0.6	0.8	3.3	-0.8	0.6	-0.7	-1.8	0.4	-0.9	-0.2
Whole body fat-free mass	0.6	3.6	12.0	0.4	-0.4	1.6	3.5	0.6	2.7	1.7
Leg fat-free mass (right)	0.6	3.3	9.5	0.8	0.0	1.2	3.1	1.0	2.4	2.1
Osteoporosis (self-reported)	0.6	0.8	3.5	1.9	0.4	0.6	0.8	-0.4	-0.5	0.4
Medication: Gliclazide	0.6	0.7	1.7	0.2	-0.3	1.2	1.3	0.6	1.0	-0.5
Leg predicted mass (right)	0.6	3.1	9.0	0.7	-0.0	1.2	3.0	0.9	2.4	2.1
Arm fat mass (left)	0.6	2.3	9.4	0.5	-0.0	1.3	3.1	0.8	2.0	-0.1
Guilty feelings	0.6	0.9	4.3	-0.4	0.3	-1.2	0.3	-0.7	0.1	2.1
Risk taking	0.6	0.8	2.6	-0.9	-0.3	0.2	0.8	-0.7	1.6	-1.1
Fractured/broken bones in last 5 years	0.6	0.8	2.1	-1.5	-1.5	-0.1	-0.4	-0.4	0.5	1.0
Ever depressed for a whole week	0.6	0.8	1.5	-1.2	-0.3	-0.3	1.0	-1.1	0.7	-1.0
Impedance of whole body	0.6	3.2	8.0	-0.5	1.4	-1.5	-2.8	-0.4	-2.6	-1.8
Leg fat mass (left)	0.6	2.3	8.7	0.2	-0.6	1.6	3.0	0.6	1.9	-0.5
Irritable Bowel Disease (IBD)	0.5	1.3	3.1	-1.8	-0.7	1.0	0.8	-1.7	1.0	-0.2
Major Depression (MDD)	0.5	0.6	2.0	0.2	-1.4	0.2	0.5	1.2	-0.3	0.0
Blood White Count	0.5	4.0	14.4	-1.3	0.9	3.8	2.9	-0.1	0.9	-1.3
Medication: Metformin	0.5	0.7	3.1	1.1	-0.6	0.5	1.8	0.0	0.3	-0.0
Townsend deprivation index at recruitment	0.5	0.7	2.7	-0.9	-1.6	0.4	-0.2	-0.5	-0.4	-1.0
Serious illness, injury or assault to yourself	0.5	0.6	1.4	0.4	0.2	-1.2	-0.5	0.5	1.0	0.9
Body mass index (BMI)	0.5	2.2	7.8	0.5	-0.2	1.7	2.8	0.7	1.9	-0.1
Trunk fat mass	0.5	2.0	8.1	0.4	0.4	1.3	2.8	0.8	1.8	-0.5
Waist circumference	0.5	1.9	5.9	0.1	-0.2	2.1	2.4	0.5	1.7	-0.1
Alcohol usually taken with meals	0.5	0.8	1.8	1.0	0.1	1.3	1.3	0.5	0.6	-0.8
Diabetes (self-reported)	0.5	0.7	2.8	0.7	0.5	0.2	1.7	-1.0	0.7	0.5
Medication: Simvastatin	0.5	0.8	1.9	1.4	0.5	1.0	0.1	1.0	-1.1	-0.3
Impedance of arm (right)	0.5	2.3	5.6	-0.7	1.3	-1.2	-2.4	-0.3	-2.1	-1.5
Noisy workplace	0.5	0.6	2.9	-0.4	0.6	0.4	0.4	-0.6	0.7	-1.7
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.5	-1.6	0.5	-0.6	-0.7	-0.2	0.6	-0.1
Prospective memory result	0.5	0.6	1.2	0.8	-1.0	0.7	1.1	0.4	0.4	0.6
Lung cancer (father)	0.5	0.5	1.5	-0.2	0.1	1.1	1.2	-0.2	0.0	-1.0
Arm fat mass (right)	0.5	2.1	8.5	0.4	-0.2	1.4	2.9	0.7	1.9	-0.2
Blood clot in the leg (DVT)	0.5	0.7	1.5	0.5	1.1	0.4	1.2	0.8	0.7	0.8
Medication: Paracetamol	0.5	0.9	1.7	-0.5	-1.3	-0.8	0.9	-0.7	1.1	1.0
Leg fat percentage (right)	0.5	1.7	4.8	0.0	-0.6	1.6	2.2	0.5	1.1	-1.6
Whole body fat mass	0.5	2.0	8.0	0.2	-0.3	1.4	2.8	1.0	1.7	-0.5
Diabetes diagnosed by doctor	0.5	0.8	3.5	0.3	-0.3	0.4	1.9	-1.2	0.5	0.1
Mineral and other dietary supplements	0.5	0.6	2.1	-1.4	0.7	0.6	-0.3	0.1	0.5	1.1
Illnesses of father: None of the above (group 1)	0.5	0.7	1.3	0.9	-1.2	0.7	0.8	1.1	0.2	0.4
Hearing aid user	0.5	0.6	1.8	-0.5	-1.3	-0.0	0.2	-1.2	0.1	-0.6
Financial situation satisfaction	0.5	0.6	2.1	0.1	-1.4	-0.5	0.7	-0.7	0.8	-0.6
Number of operations (self-reported)	0.5	0.8	3.0	-0.8	-0.2	0.1	0.4	-1.7	1.1	0.1
Age started oral contraceptive pill	0.5	0.7	2.0	1.4	0.4	-1.0	1.1	-0.3	-0.5	0.5
Pain experienced in last month	0.5	0.8	1.7	-0.1	0.3	-0.4	-1.3	-1.0	-1.0	-1.3
Heart disease (siblings)	0.5	0.6	1.4	-0.4	-0.4	-1.1	-1.2	-0.5	-1.1	0.1
Worry (Nagel 2018)	0.4	0.8	2.2	1.0	-0.4	-0.7	0.1	0.8	-1.1	1.5
Breast Cancer	0.4	1.0	3.5	0.4	0.8	1.9	0.2	-0.0	-1.5	-0.5
Lupus	0.4	0.6	2.7	0.7	-0.0	0.1	0.5	0.7	-0.2	1.6
Rheumatoid Arthritis	0.4	0.6	2.1	0.7	0.2	-1.5	-0.6	-0.5	0.7	0.6
Respiratory disease	0.4	1.0	4.1	-2.0	0.1	0.2	-0.2	-1.5	-0.0	-0.6
Type 2 Diabetes (T2D) (2018)	0.4	0.8	3.2	1.8	-1.2	0.1	0.7	0.3	0.4	0.6
Chronotype (morning person)	0.4	1.0	2.8	1.6	-0.4	-0.9	0.1	0.6	-0.7	1.7
Systolic blood pressure, automated reading	0.4	1.1	2.5	0.4	0.3	1.2	1.6	0.8	1.4	0.9
Diabetes (mother)	0.4	0.5	1.4	0.0	-0.5	-0.7	-1.1	1.2	0.3	-0.3
Pack years adult smoking proportion	0.4	0.5	1.3	0.1	-0.5	1.0	1.0	1.2	0.0	0.4
Maternal smoking around birth	0.4	0.6	1.7	-1.0	0.2	0.0	1.3	-0.5	0.8	-0.7
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.9	0.3	1.4	-0.5	-0.9	-0.1	-1.7	0.5
Supplements: Glucosamine	0.4	0.6	2.0	0.4	0.9	0.8	0.4	0.3	0.4	-1.4
Allergy	0.4	1.0	4.0	-0.0	-1.5	0.3	0.7	0.5	2.0	0.4
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.8	0.6	0.7	-0.8	-0.1	0.3	-1.3	0.7
Arm fat percentage (right)	0.4	1.5	5.2	0.5	-0.4	1.2	2.3	0.9	1.3	-0.9
Pulse rate	0.4	0.6	2.8	0.3	-0.6	-0.2	0.6	0.6	-0.5	1.7
Tense / ‘highly strung’	0.4	0.6	2.0	-0.4	-0.2	-1.2	-0.8	-0.5	-1.4	0.2
High blood pressure (siblings)	0.4	0.6	2.1	0.0	-0.0	1.0	1.4	-0.6	0.7	-0.3
Age at first live birth	0.4	0.6	3.0	1.7	0.0	-0.3	-0.2	0.6	-0.9	0.4
Pulse wave peak to peak time	0.4	0.4	1.6	1.3	-0.9	-0.5	0.6	0.2	0.3	0.2
Neck or shoulder pain in last month	0.4	0.6	2.2	0.3	-0.3	-0.5	0.8	0.4	0.7	1.5
Angina (self-reported)	0.4	0.6	1.7	1.0	0.1	1.3	0.6	0.7	-0.4	-0.5
Mean time to correctly identify matches	0.4	0.7	3.0	-0.6	-0.6	-1.7	-0.7	-0.6	0.4	-0.6
Alcohol intake frequency.	0.4	0.9	1.5	1.1	-1.2	-0.9	-1.2	-0.2	-1.1	0.2
Suffer from ‘nerves’	0.4	0.6	1.6	0.7	-1.0	-0.5	0.2	0.9	-1.3	-0.1
Chest pain or discomfort	0.4	0.6	1.3	-0.0	-0.6	0.6	0.8	0.3	1.1	-1.1
Leg pain on walking	0.4	0.5	1.3	-1.1	0.4	0.3	0.9	0.0	0.6	-1.1
Medication: Aspirin	0.4	0.5	1.1	-0.3	-1.0	0.6	-0.3	0.1	-0.8	-1.1
Back pain experienced in last month	0.4	0.6	1.9	-0.4	-0.4	-0.3	1.4	-0.7	1.1	0.4
Medication: Aspirin	0.4	0.5	1.2	-0.1	-1.1	0.8	-0.2	0.3	-0.6	-0.9
Ever taken oral contraceptive pill	0.4	0.4	1.0	0.2	0.8	0.8	0.2	0.7	0.0	1.0
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.3	-0.2	-0.6	0.6	0.7	-0.6	1.1	-0.3
Commuting to job workplace: Public transport	0.4	0.5	1.8	-0.1	-0.4	0.7	0.5	1.3	-0.8	0.2
Pain type(s) experienced in last month: Hip pain	0.4	0.4	2.0	1.4	0.4	-0.1	0.3	0.9	-0.2	-0.3
Leg fat percentage (left)	0.4	1.5	4.3	0.2	-0.4	1.7	2.1	0.5	1.1	-1.4
Pack years of smoking	0.4	0.6	1.5	-0.4	-0.3	1.1	1.2	1.0	-0.0	-0.3
Body Mass Index (BMI) (2010)	0.3	0.4	0.8	-0.2	-0.9	0.3	0.8	-0.8	0.3	0.5
Mean Putamen Volume	0.3	0.4	1.3	0.2	-0.5	-1.1	0.5	-0.8	0.0	-0.2
Ulcerative Colitis	0.3	0.4	0.9	0.2	-0.6	0.9	0.4	0.1	0.9	0.7
Blood Eosinophil Count	0.3	1.9	9.4	0.1	-3.1	-1.4	-1.0	0.1	-0.9	0.7
Allergy or Eczema	0.3	0.8	2.1	-0.7	1.5	-0.2	-0.8	-1.0	-1.1	-0.6
Lung FEV1/FVC ratio	0.3	1.4	5.1	2.3	0.2	0.9	-0.8	1.4	-0.3	0.9
Lung FVC	0.3	1.6	4.5	-1.1	-0.1	-2.1	-0.0	-1.6	0.9	1.5
Neuroticism	0.3	0.7	3.3	0.5	0.3	-0.3	0.9	0.4	0.1	1.8
Ever used hormone-replacement therapy (HRT)	0.3	0.4	2.0	0.0	-0.4	0.5	1.4	-0.1	0.7	0.0
Trunk fat percentage	0.3	1.1	3.8	0.2	0.5	1.0	1.9	0.6	1.0	-1.1
Taking other prescription medications	0.3	0.5	1.4	-1.1	0.2	0.2	0.7	-1.2	-0.1	-0.6
Had other major operations	0.3	0.4	1.5	-0.5	-1.2	-0.2	0.3	-0.7	0.0	0.5
Qualifications: None of the above	0.3	0.7	1.7	0.9	0.3	0.9	0.7	0.8	0.6	-1.3
Medication: Ramipril	0.3	0.4	1.3	0.2	-1.1	0.7	0.5	0.5	-0.3	-0.9
Mouth/teeth dental problems: Dentures	0.3	0.5	1.4	1.0	-1.2	-0.5	-0.2	0.3	0.5	-0.4
Asthma	0.3	0.6	1.4	-1.2	-0.1	-0.5	-0.4	-0.7	-1.2	-0.7
Illnesses of mother	0.3	0.4	1.7	0.6	0.6	-0.3	0.6	0.2	1.3	0.2
Pulse wave Arterial Stiffness index	0.3	0.4	1.6	-1.2	0.7	0.4	-0.7	-0.1	-0.3	-0.1
Breastfed as a baby	0.3	0.4	1.3	-1.1	-0.3	0.1	-0.7	-0.2	0.8	0.2
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.5	-0.3	0.5	0.4	0.8	0.1	1.2	0.9
Body fat percentage	0.3	1.2	4.5	0.2	-0.1	1.0	2.1	0.7	1.0	-1.3
Comparative body size at age 10	0.3	0.9	3.6	1.4	0.1	-1.9	-0.3	0.0	0.5	0.5
Medication for pain relief, constipation, heartburn	0.3	0.6	3.5	0.4	1.9	0.3	-0.1	0.0	0.3	-0.1
Pulse rate, automated reading	0.3	0.9	3.5	-0.8	0.1	0.9	1.9	-0.5	0.2	-0.8
Overall health rating	0.3	0.6	1.6	-0.3	-1.0	-0.8	-0.2	-0.7	-1.3	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.7	-0.8	0.5	0.3	-0.0	-0.6	0.6	0.6
Illnesses of siblings: Diabetes	0.3	0.4	1.4	1.2	0.1	0.7	0.6	0.2	-0.7	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.4	-0.3	0.9	1.0	1.0	-0.7	1.2	0.1
Arm fat percentage (left)	0.3	1.3	5.1	0.7	0.1	1.0	2.2	1.1	1.1	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.1	1.0	0.4	0.0	0.0	0.8	1.0	0.4
Asthma (self-reported)	0.3	0.7	2.0	-1.1	-0.2	-0.6	-0.5	-0.7	-1.4	-0.6
Number of self-reported non-cancer illnesses	0.3	0.6	0.9	-0.8	0.9	0.4	0.7	-0.8	-0.7	-0.7
Mother’s age at death	0.3	0.4	1.1	0.7	-0.5	-0.1	-0.3	0.4	-0.7	-1.1
Ever smoked	0.3	0.6	1.8	-0.4	-0.4	0.6	0.9	0.6	1.4	-0.5
Average weekly beer plus cider intake	0.3	0.4	1.0	-1.0	0.6	-0.3	-0.2	-0.7	0.8	-0.7
Unable to work because of sickness or disability	0.3	0.4	1.7	-0.2	-0.2	0.8	0.4	-0.1	0.4	-1.3
Commuting to job workplace: Cycle	0.3	0.4	1.2	0.3	-1.1	0.1	0.8	0.3	0.0	-0.7
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.3	0.1	-0.2	-1.5	-1.1	0.4	0.1	1.4
Supplements: Calcium	0.3	0.4	0.9	-0.8	-0.5	0.2	-0.2	-1.0	-0.2	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.2	0.2	1.1	0.5	0.9	0.4	0.5	0.6
Alcohol drinker status: Previous	0.3	0.3	0.6	0.2	-0.8	-0.1	-0.6	-0.6	-0.3	-0.8
Ulcerative Colitis (UC)	0.2	0.4	1.8	-0.1	-0.4	-0.3	-1.3	0.2	-0.1	1.0
Reaction Time	0.2	0.4	1.7	-0.4	0.3	-1.3	-0.6	-0.6	0.4	-0.2
Heel T-Score	0.2	1.3	3.5	0.6	-0.6	-0.8	1.9	-1.2	1.7	-0.4
BMI	0.2	1.4	3.2	1.2	-0.1	0.9	1.8	1.0	1.8	0.3
Waist Hip Ratio (WHR)	0.2	1.1	5.1	0.1	1.1	2.3	-0.1	0.4	1.0	0.3
Systolic Blood Pressure	0.2	0.8	1.8	-0.5	0.2	0.6	1.1	-0.1	1.3	1.4
Smoking Status	0.2	0.6	1.3	-0.0	-0.8	0.5	0.6	1.1	1.2	-0.1
Cardiovascular Disease	0.2	0.5	1.0	0.4	0.8	0.8	0.9	0.2	-0.5	1.0
Number of treatments/medications taken	0.2	0.3	0.9	-0.1	-0.9	0.1	0.8	-0.9	0.1	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.4	1.0	-0.2	-1.2	0.8	-0.1	0.2	0.0
High blood pressure	0.2	0.6	2.0	0.2	0.5	1.2	1.4	-0.3	0.1	-0.6
High blood pressure (mother)	0.2	0.3	1.6	-0.1	0.6	-0.1	-0.4	-0.1	-1.3	0.4
Number of incorrect matches in round	0.2	0.4	1.3	-0.6	-1.1	0.7	0.6	-0.3	0.3	0.2
Neuroticism score	0.2	0.5	2.1	0.4	-0.2	-0.9	-0.2	0.3	-0.5	1.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.7	0.6	-0.1	-1.1	-0.9	-0.7	0.4	1.3
Medication: Lansoprazole	0.2	0.3	0.8	-0.4	0.6	0.6	-0.4	0.4	-0.1	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	2.2	0.2	0.2	-1.5	-0.6	-1.4	0.4	0.4
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.6	-0.3	0.6	0.5	0.6	-0.7	0.2	-0.8
Headache pain in last month	0.2	0.3	1.3	-0.8	-0.3	-0.0	-0.2	0.4	0.3	1.2
Gout (self-reported)	0.2	0.3	0.8	-0.3	-0.6	-0.1	0.6	-0.8	0.1	-0.9
Forced vital capacity (FVC), Best measure	0.2	0.7	3.3	0.4	0.2	-1.8	-0.6	-0.6	0.2	0.9
Wheeze or whistling in the chest in last year	0.2	0.4	1.5	0.2	-0.4	-0.2	1.2	-0.6	0.8	0.0
Qualifications: College or University degree	0.2	0.6	1.7	0.3	-0.0	-1.2	-1.3	-0.6	-0.8	-0.1
Medication: Blood pressure	0.2	0.3	0.9	0.4	-0.9	-0.4	-0.1	-0.2	-0.7	-0.5
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.7	-0.0	0.8	0.0	0.1	-0.2	-0.8	0.3
Knee pain experienced in last month	0.2	0.4	1.3	0.2	-0.1	-0.2	1.0	-1.1	0.5	0.0
Hypertension (Self-reported)	0.2	0.5	2.2	0.5	0.3	0.9	1.5	0.1	0.2	-0.3
Average weekly red wine intake	0.2	0.4	1.0	0.3	-0.2	-0.5	0.7	-0.6	0.6	-1.0
Long-standing illness, disability or infirmity	0.2	0.3	1.1	-0.3	-1.1	-0.3	0.5	-0.2	-0.3	0.6
Qualifications: nursing, teaching	0.2	0.3	1.0	-1.0	0.5	0.2	0.5	-0.2	0.4	-0.3
Medication for cholesterol	0.2	0.4	1.8	0.3	-0.2	0.1	0.5	-0.1	1.4	-0.4
Osteoarthritis (self-reported)	0.2	0.2	0.4	0.4	0.5	-0.0	0.4	0.5	0.4	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.1	1.1	0.3	-0.6	-0.6	-0.4	0.6	-0.4
Medication: Blood pressure	0.2	0.4	1.9	-0.5	-0.0	0.1	0.2	-0.2	-1.4	-0.7
Medication: Lisinopril	0.2	0.3	0.7	-0.4	-0.1	-0.8	-0.8	0.2	-0.6	-0.3
Diastolic blood pressure, automated reading	0.2	0.6	3.1	-0.5	-0.2	1.8	0.7	-0.2	0.4	-0.1
Cholesterol lowering medication	0.2	0.3	1.2	-0.5	0.2	0.7	0.1	-0.1	-1.1	-0.7
Bipolar Disorder (2018)	0.1	0.2	0.7	0.4	-0.5	0.1	-0.2	0.8	0.5	0.2
Schizophrenia vs Biploar Disorder	0.1	0.2	0.7	0.2	0.1	-0.8	0.3	-0.4	0.0	-0.1
Ovarian Cancer	0.1	0.2	0.3	0.4	-0.5	-0.3	0.5	0.4	0.4	-0.4
Neuroticism (2016)	0.1	0.1	0.4	-0.7	0.3	-0.4	-0.4	-0.1	-0.1	0.3
Hair Pigment	0.1	1.5	4.6	-2.1	0.6	-1.6	0.6	-1.6	0.0	0.3
Tanning	0.1	1.5	4.9	-0.8	1.2	0.8	1.2	-1.2	2.2	-0.1
Age when periods started (menarche)	0.1	0.4	1.8	-0.1	-1.3	0.8	0.1	0.0	0.3	0.3
Sitting height	0.1	0.7	2.4	-0.7	0.7	0.2	1.6	-0.8	0.6	0.3
Forced vital capacity (FVC)	0.1	0.6	1.8	0.3	0.2	-1.3	-0.5	-0.4	0.2	1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.7	-0.0	0.5	0.2	0.8	-0.7	0.6	-0.7
Hip circumference	0.1	0.5	1.8	-0.6	-0.2	0.6	1.4	-0.1	0.4	-1.0
Qualifications: A levels/AS levels or equivalent	0.1	0.3	1.2	0.2	1.1	0.5	-0.4	0.4	0.1	0.3
Standing height	0.1	0.6	1.5	-0.8	0.7	0.0	1.2	-0.3	1.1	0.9
Birth weight	0.1	0.3	0.7	0.3	0.8	0.7	0.2	0.2	0.7	-0.3
Comparative height size at age 10	0.1	0.7	1.9	-0.4	-0.4	-0.8	1.0	0.2	1.4	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.4	-0.5	-0.2	-0.2	-0.5	0.1	0.3	0.6
Height	0.0	0.5	1.6	-0.3	0.2	-0.0	1.1	-0.4	0.6	1.3

Hub : Genes

CD82

Models

Trait associations