Hub : Genes

LGR4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.1170 0.0450 0.0024 0.013 NA 0.017 NA -0.001 0.0330 NA 0.01900 NA 0.3500
2 METSIM Adipose 0.0271 0.0124 0.0063 0.007 0.013 0.020 0.012 0.011 0.0250 0.0042 0.00046 0.005 0.0082
3 TCGA Prostate Adenocarcinoma 0.0420 0.0228 0.0034 0.015 0.022 0.020 NA 0.020 0.0088 0.0020 0.00290 NA 0.0029

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.2 0.4 0.4 0.6 -0.5 -0.7
Bipolar Disorder or Schizophrenia 0.4 1.0 1.5 -1.1 -1.2 -0.3
Depressed Affect (Nagel 2018) 0.6 1.3 3.3 0.6 -0.5 1.8
Depression (Nagel 2018) 0.1 0.2 0.6 0.1 0.8 -0.2
Intelligence (Savage-Jansen 2018) 0.3 0.8 2.3 0.3 0.2 1.5
Neuroticism (Nagel 2018) 0.1 0.2 0.4 -0.4 -0.6 0.1
Schizophrenia (2018) 0.8 1.7 3.7 -1.9 -1.2 0.2
Schizophrenia vs Biploar Disorder 1.0 1.3 3.5 -1.9 -0.7 0.3
Worry (Nagel 2018) 1.0 2.1 3.4 -1.7 0.1 -1.9
Alzheimer’s Disease (in mother) 0.3 0.3 0.5 0.4 0.7 0.5
Alzheimer’s Disease (in father) 2.5 2.7 6.7 0.3 2.6 -1.1
Alzheimer’s Disease (including proxy) 1.2 1.7 4.2 1.0 2.0 -0.1
Crohns Disease (2017) 0.4 0.8 1.3 -1.0 1.1 0.4
Irritable Bowel Disease (IBD) 0.6 1.3 2.1 -1.3 1.5 -0.6
Ulcerative Colitis (UC) 0.7 1.4 2.0 -1.4 0.9 -1.2
Major Depression (MDD) 2.0 2.4 5.7 -1.1 -0.5 -2.4
Reaction Time 0.6 1.2 2.4 1.0 -1.6 -0.5
Verbal and Numeric Reasoning (VNR) 0.2 0.4 1.0 0.3 0.2 1.0
Breast Cancer 0.2 0.5 0.9 0.3 1.0 0.6
Ovarian Cancer 1.7 2.2 6.4 0.5 -2.5 0.1
Prostate Cancer 2.4 3.3 3.9 -1.8 -2.0 1.6
Age at First Birth 0.4 0.6 1.9 -0.0 1.4 0.2
Bipolar Disorder (2011) 0.2 0.2 0.3 0.5 0.5 -0.0
Body Mass Index (BMI) (2010) 2.1 2.8 8.1 0.3 -2.9 0.5
Coronary Artery Disease (CAD) 2.1 2.5 4.1 1.3 -2.0 1.3
Crohns Disease (2012) 1.2 1.9 3.5 -1.9 1.5 -0.0
Mean Putamen Volume 0.5 0.6 1.5 0.0 -0.4 -1.2
Fasting Glucose 1.0 1.2 2.3 0.4 -1.5 1.1
HbA1C 0.4 0.4 0.9 -0.4 0.9 -0.5
HDL Cholesterol 1.3 2.1 3.5 -1.5 1.9 -0.7
LDL Cholesterol 0.7 1.1 2.0 -1.4 0.8 -0.8
Lupus 0.8 1.3 1.8 1.2 1.3 0.7
Neuroticism (2016) 1.6 2.3 6.3 -2.5 0.2 -0.7
Primary Biliary Cirrhosis 1.1 1.6 2.0 -1.2 1.4 -1.2
Rheumatoid Arthritis 0.8 1.1 1.3 1.1 -1.0 0.9
Schizophrenia (2014) 0.6 1.4 2.0 -1.4 -1.4 -0.4
Triglycerides 0.8 1.4 3.6 -0.1 -1.9 0.6
Type 2 Diabetes (T2D) (2012) 1.8 2.0 5.5 -0.0 2.4 0.8
Ulcerative Colitis 2.3 3.4 5.4 -1.9 0.9 -2.3
Blood Eosinophil Count 0.5 3.5 8.4 1.2 -2.9 0.8
Blood Platelet Count 0.0 0.4 0.9 0.1 0.9 -0.6
Blood Red Count 0.6 5.3 9.4 2.3 3.1 -1.0
Blood White Count 0.2 1.3 3.5 1.9 0.5 -0.0
Heel T-Score 3.1 24.5 61.2 3.4 7.8 0.9
BMI 2.3 13.5 33.1 0.6 -5.8 2.7
Height 0.3 4.9 10.1 1.8 -1.1 3.2
Waist Hip Ratio (WHR) 0.5 2.5 5.1 -1.4 2.3 -0.5
Systolic Blood Pressure 4.6 23.0 36.4 -3.2 4.8 -6.0
Smoking Status 0.6 1.4 3.5 0.4 -1.9 -0.8
Allergy or Eczema 0.8 2.2 4.5 2.1 -1.4 0.5
Cardiovascular Disease 1.0 3.4 7.3 -1.3 1.1 -2.7
Hypothyroidism (self reported) 0.3 0.6 1.6 0.4 1.3 0.4
Respiratory disease 0.8 1.8 2.9 1.7 -1.2 1.1
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.1 1.0 0.6 -0.0
Lung FEV1/FVC ratio 0.3 1.4 3.2 -1.8 0.8 -0.4
Lung FVC 0.2 1.2 2.7 -0.2 1.0 -1.6
Neuroticism 0.6 1.4 4.1 -2.0 -0.1 -0.0
Chronotype (morning person) 0.2 0.5 1.2 0.4 0.4 1.1
Hair Pigment 0.1 3.6 8.2 2.9 -1.6 0.3
Tanning 0.0 0.1 0.3 0.0 -0.5 0.3
Hand grip strength (left) 0.1 0.3 0.5 -0.1 -0.7 0.7
Number of treatments/medications taken 0.1 0.3 0.4 0.6 -0.7 -0.1
Average weekly spirits intake 0.8 1.0 2.0 1.4 -0.9 0.1
Sensitivity / hurt feelings 0.6 1.0 2.8 -1.7 -0.5 -0.2
Frequency of depressed mood in last 2 weeks 0.1 0.2 0.2 0.3 0.4 0.4
Hearing difficulty/problems: Yes 0.2 0.2 0.5 0.2 -0.7 0.4
Relative age of first facial hair 1.8 3.6 9.1 3.0 -0.0 1.3
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 1.4 1.2 0.3 0.7
Ever used hormone-replacement therapy (HRT) 0.3 0.4 0.7 0.5 0.6 -0.8
Ever had hysterectomy (womb removed) 2.0 2.2 3.5 0.4 1.7 -1.9
Systolic blood pressure, automated reading 1.5 4.4 6.6 -1.8 1.8 -2.6
Eye problems/disorders: Diabetes related eye disease 0.7 0.7 1.8 -0.6 0.1 -1.3
Angina 2.0 2.7 5.7 2.4 -0.9 1.2
Medication for hormone replacement therapy 0.3 0.4 1.1 0.1 1.0 0.1
Vitamin and mineral supplements 0.3 0.5 0.8 0.9 -0.6 0.4
Supplements: Zinc 0.8 0.8 1.8 1.3 -0.1 0.9
Medication: Co-codamol 0.8 0.9 2.4 -0.5 0.5 -1.5
Medication: Metformin 0.9 1.2 3.5 1.9 -0.2 0.3
Diabetes (father) 1.3 1.6 3.1 1.2 -0.6 1.8
Diabetes (mother) 0.0 0.1 0.1 0.1 -0.3 0.3
Severe depression (siblings) 0.7 0.8 2.0 1.4 -0.2 -0.4
Pack years adult smoking proportion 1.1 1.6 2.6 0.7 -1.6 1.3
Impedance of leg (right) 0.2 1.0 2.5 -0.6 1.6 -0.4
Leg fat-free mass (left) 1.3 6.9 10.3 1.4 -3.2 2.9
Trunk fat percentage 2.5 10.2 15.7 2.0 -4.0 3.3
Hand grip strength (right) 0.0 0.0 0.1 -0.3 0.0 -0.0
Townsend deprivation index at recruitment 1.4 2.0 2.9 1.7 -1.4 1.1
Current tobacco smoking 0.3 0.4 1.2 0.2 -1.1 -0.0
Average weekly fortified wine intake 0.2 0.2 0.6 0.4 -0.1 -0.8
Maternal smoking around birth 0.3 0.4 1.0 0.3 -1.0 -0.4
Fed-up feelings 0.3 0.6 1.1 0.6 0.4 1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.6 1.8 -0.1 1.4 -0.3
Relative age voice broke 0.9 1.4 2.7 1.2 1.6 0.4
Taking other prescription medications 0.3 0.4 0.6 0.6 -0.8 0.5
Age when periods started (menarche) 0.7 1.8 3.7 -0.5 1.9 1.2
Bilateral oophorectomy (both ovaries removed) 1.9 2.2 4.5 -0.3 1.4 -2.1
Heel bone mineral density (BMD) T-score, automated (left) 1.9 4.2 8.8 2.0 3.0 0.2
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.6 0.4 -0.2 0.8
Qualifications: CSEs or equivalent 1.3 1.8 3.5 -1.9 1.3 -0.4
Serious illness, injury or assault to yourself 1.0 1.3 3.5 1.9 0.1 -0.6
High blood pressure 0.8 2.2 2.6 -1.2 1.5 -1.6
Hayfever, allergic rhinitis or eczema 0.5 1.0 2.1 1.5 -1.0 0.3
Multivitamins +/- minerals 0.4 0.6 1.1 -0.2 1.1 -0.7
Stomach or abdominal pain in last month 1.1 1.4 4.1 -0.3 -2.0 0.1
Supplements: Glucosamine 0.6 0.8 1.3 0.0 1.0 -1.2
Diverticular disease/diverticulitis (self-reported) 0.4 0.4 0.8 -0.9 0.4 -0.6
Medication: Atenolol 0.7 0.9 1.8 0.1 0.9 -1.4
Medication: Levothyroxine sodium 0.6 1.1 1.5 0.8 1.2 1.1
Sitting height 0.5 3.4 8.6 1.0 -0.8 2.9
Chronic bronchitis/emphysema (father) 0.5 0.6 1.0 1.0 -0.4 -0.8
High blood pressure (mother) 0.0 0.1 0.2 -0.2 0.4 -0.1
Body mass index (BMI) 2.1 9.2 18.2 1.1 -4.3 2.8
Impedance of leg (left) 0.4 1.8 4.4 -0.6 2.1 -0.8
Leg predicted mass (left) 1.3 6.8 10.2 1.4 -3.2 2.8
Trunk fat mass 3.1 13.4 19.3 2.2 -4.4 4.0
Waist circumference 2.7 10.0 13.4 1.8 -3.7 3.6
Number of incorrect matches in round 0.1 0.2 0.4 -0.6 0.1 -0.3
Past tobacco smoking 0.4 0.8 2.2 -0.5 1.5 -0.0
Alcohol usually taken with meals 1.1 1.8 4.9 -0.3 2.2 -0.6
Nervous feelings 2.7 5.1 8.3 -2.9 1.6 -2.2
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.3 -0.6 -0.2 -0.6
Hearing difficulty/problems with background noise 1.5 2.4 5.1 -0.8 -2.3 1.2
Hair/balding pattern: Pattern 2 5.5 7.0 18.4 -0.4 4.3 -1.6
Had menopause 1.5 1.9 3.1 -1.7 1.5 -0.3
Had other major operations 2.0 2.5 7.5 2.7 0.2 0.0
Forced vital capacity (FVC) 0.0 0.0 0.1 -0.1 0.2 0.3
Heel bone mineral density (BMD) T-score, automated (right) 2.4 5.5 14.4 1.4 3.8 -0.6
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 0.8 0.9 -0.7 -0.3
Qualifications: None of the above 0.6 1.4 3.8 0.2 -2.0 0.5
Financial difficulties in last 2 years 0.3 0.4 0.5 0.7 -0.7 0.5
Mouth/teeth dental problems 1.9 2.9 5.2 -2.3 1.1 -1.5
Heart attack 2.7 3.4 5.9 2.4 -0.4 2.1
Allergy 0.7 1.7 4.0 -2.0 0.9 -0.6
Pain all over the body in last month 0.1 0.1 0.2 0.4 0.5 -0.2
Diabetes (self-reported) 0.9 1.4 3.3 1.8 0.1 0.9
Hayfever/allergic rhinitis (self-reported) 1.3 1.7 3.1 1.8 -0.6 1.3
Medication: Ramipril 0.5 0.6 1.3 0.8 -1.2 0.0
Medication: Simvastatin 0.8 1.2 2.6 -0.2 1.0 -1.6
Fluid intelligence score 0.2 0.5 0.8 0.9 0.9 0.1
Illnesses of siblings 0.4 0.5 1.1 -1.1 0.5 -0.5
Neuroticism score 1.1 2.2 6.1 -2.5 0.6 -0.5
Weight 2.4 11.8 16.7 1.8 -4.1 4.0
Impedance of arm (right) 0.2 0.7 2.0 0.4 1.4 0.2
Arm fat percentage (right) 2.8 10.9 19.2 1.8 -4.4 3.2
Trunk fat-free mass 1.0 5.9 8.7 1.1 -2.8 3.0
Hip circumference 2.5 10.7 15.4 2.1 -3.9 3.5
Time employed in main current job 0.0 0.0 0.1 0.3 -0.2 0.0
Alcohol intake versus 10 years previously 0.9 1.4 2.4 -1.1 1.6 -0.7
Father’s age at death 2.0 2.7 5.1 -1.6 2.2 -0.9
Worrier / anxious feelings 1.4 2.7 6.2 -2.5 0.7 -1.2
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 1.7 0.4 0.3 1.3
Falls in the last year 6.9 9.3 21.0 2.2 -4.6 1.5
Hair/balding pattern: Pattern 3 8.9 13.3 20.6 1.1 -4.5 4.3
Number of live births 1.3 1.8 5.0 2.2 -0.6 -0.1
Forced expiratory volume in 1-second (FEV1) 0.1 0.2 0.4 -0.6 0.4 -0.2
Pulse rate 0.6 1.0 1.9 -1.4 1.0 0.4
Happiness 0.6 0.8 1.1 -1.1 1.0 -0.3
Noisy workplace 0.1 0.1 0.3 0.1 -0.1 -0.5
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.5 0.7 0.2 0.2
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 1.6 1.3 0.6 0.3
Mouth/teeth dental problems: Dentures 2.2 3.7 4.8 2.2 -2.0 1.4
Asthma 0.1 0.2 0.4 0.5 0.1 0.6
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 1.7 -1.3 1.0 -0.1
Medication: Cholesterol lowering 0.1 0.2 0.5 0.7 -0.2 0.2
Depression (self-reported) 0.4 0.4 1.1 0.2 0.4 1.0
Medication: Lansoprazole 2.4 2.7 5.4 -0.9 1.4 -2.3
Prospective memory result 0.5 0.7 1.2 1.1 -0.8 0.2
Lung cancer (father) 0.0 0.1 0.1 -0.2 0.3 -0.1
Illnesses of mother 0.3 0.4 1.1 1.0 -0.5 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.3 2.0 -1.0 1.4 -0.9
Pulse wave Arterial Stiffness index 0.3 0.4 0.7 -0.5 -0.4 0.9
Impedance of arm (left) 0.2 1.0 2.5 0.7 1.6 -0.1
Arm fat mass (right) 2.5 10.2 18.6 1.4 -4.3 3.2
Trunk predicted mass 1.0 5.9 8.8 1.1 -2.8 3.0
Standing height 0.4 3.8 8.6 1.7 -0.4 2.9
Length of working week for main job 0.5 0.6 1.2 0.5 -0.5 1.1
Exposure to tobacco smoke at home 2.7 3.1 4.7 -2.0 0.8 -2.2
Breastfed as a baby 0.6 0.7 1.6 0.8 -0.0 -1.3
Tense / ‘highly strung’ 0.5 0.8 1.2 1.0 -1.1 -0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 0.7 0.8 -0.4 0.5
Hair/balding pattern: Pattern 4 11.7 28.2 36.0 4.6 -5.2 6.0
Birth weight of first child 0.8 1.5 2.9 1.2 0.1 1.7
Peak expiratory flow (PEF) 0.1 0.3 0.6 0.2 0.3 0.8
Pulse wave reflection index 0.2 0.2 0.3 -0.3 -0.5 -0.4
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.6 0.2 -0.8 0.2
Loud music exposure frequency 0.7 0.8 1.8 -1.4 -0.2 -0.6
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 1.3 -0.9 1.1 -0.9
Mouth/teeth dental problems: Bleeding gums 0.4 0.6 1.2 -0.3 0.6 -1.1
Blood clot in the leg (DVT) 0.2 0.3 0.8 0.9 0.1 0.1
Medication: Paracetamol 1.0 1.7 2.9 -1.7 1.1 -1.0
Headache pain in last month 1.4 2.4 4.2 -2.0 1.4 -0.9
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.5 -0.4 0.7 0.1
Glaucoma (self-reported) 0.4 0.5 0.9 -0.9 0.6 -0.5
Gout (self-reported) 2.6 3.5 5.3 1.2 -2.3 2.0
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 2.3 0.1 1.5 0.8
Medication: Amlodipine 1.9 2.7 4.4 -1.7 2.1 -1.0
Medication: Ventolin 100micrograms inhaler 1.0 1.3 3.6 0.5 -0.3 1.9
Birth weight 0.2 0.5 0.9 0.9 -0.0 0.8
Chronic bronchitis/emphysema (mother) 0.5 0.6 0.8 0.5 -0.9 0.8
High blood pressure (siblings) 0.5 0.8 1.6 -0.6 -1.3 -0.6
Forced vital capacity (FVC), Best measure 0.1 0.4 1.3 -0.1 1.1 -0.2
Body fat percentage 2.6 10.2 16.6 1.8 -4.1 3.3
Leg fat percentage (right) 2.6 9.3 15.5 1.2 -3.9 3.3
Arm fat-free mass (right) 0.9 4.7 8.2 0.6 -2.9 2.4
Exposure to tobacco smoke outside home 1.2 1.5 2.3 1.3 -1.5 0.8
Comparative body size at age 10 3.4 9.5 13.6 2.2 -3.7 3.2
Number of full brothers 1.0 1.2 2.8 -0.7 -1.7 0.6
Worry too long after embarrassment 0.8 1.3 3.3 -1.8 0.4 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 1.5 2.0 3.4 -1.0 1.9 -1.2
Wheeze or whistling in the chest in last year 3.9 6.9 9.0 2.8 -3.0 2.0
Number of children fathered 0.8 0.8 0.9 -0.8 1.0 -1.0
Reason for reducing amount of alcohol drunk: Health precaution 1.8 2.0 3.8 -1.5 -1.9 -0.1
Age at first live birth 1.2 2.2 5.8 -2.4 0.9 -0.1
Pulse wave peak to peak time 0.2 0.3 0.4 0.5 0.4 -0.6
Health satisfaction 0.9 1.2 2.2 0.9 -1.5 0.7
Shortness of breath walking on level ground 1.5 1.8 2.7 -0.3 -1.6 1.6
Qualifications: College or University degree 0.2 0.5 1.4 0.3 1.2 -0.3
Eye problems/disorders: None of the above 1.0 1.2 1.8 1.4 0.3 1.3
Mouth/teeth dental problems: Loose teeth 0.9 1.0 1.6 1.3 0.2 1.2
Emphysema/chronic bronchitis 0.6 0.7 1.3 1.2 -0.8 0.3
Medication for pain relief, constipation, heartburn 0.1 0.1 0.2 -0.0 0.5 0.3
Neck or shoulder pain in last month 1.2 1.7 2.7 0.9 -1.3 1.6
Medication: Blood pressure 0.5 0.9 1.3 1.0 -1.1 0.6
Angina (self-reported) 2.2 2.9 6.6 2.6 -0.7 1.3
Migraine (self-reported) 2.0 2.5 4.2 -1.3 2.0 -1.3
Medication: Ibuprofen 0.3 0.3 0.6 -0.5 0.4 0.8
Medication: Allopurinol 2.5 3.4 4.2 1.5 -2.0 1.9
Medication: Omeprazole 1.9 2.3 5.7 -1.0 -2.4 -0.3
Medication: Seretide 50 evohaler 1.3 1.5 2.0 1.4 -1.4 0.7
Mean time to correctly identify matches 0.6 1.2 2.5 1.6 -1.0 -0.3
Heart disease (mother) 0.2 0.2 0.6 0.0 -0.3 -0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.3 -0.4 -0.3 -0.6
Whole body fat mass 2.9 12.1 19.6 1.7 -4.4 3.7
Leg fat mass (right) 3.1 11.9 20.2 1.2 -4.5 3.7
Arm predicted mass (right) 0.9 4.6 7.2 0.6 -2.7 2.5
Pulse rate, automated reading 0.2 0.6 1.2 -0.1 0.9 1.1
Alcohol intake frequency. 0.0 0.1 0.3 -0.2 0.0 0.5
Comparative height size at age 10 1.6 8.9 9.9 2.7 -3.1 3.1
Number of full sisters 3.2 3.9 6.8 1.8 -2.6 1.3
Suffer from ‘nerves’ 1.6 2.5 6.6 -2.6 0.8 -0.5
Overall health rating 0.1 0.2 0.4 0.7 -0.4 0.2
Chest pain or discomfort 3.2 4.7 9.1 3.0 -2.0 0.9
Had major operations 4.5 5.3 7.3 2.7 -2.6 1.3
Age at last live birth 0.2 0.3 0.7 -0.8 0.2 0.4
Family relationship satisfaction 0.4 0.4 0.7 0.2 0.8 0.8
Leg pain on walking 0.8 1.0 2.3 -0.7 -0.4 -1.5
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 1.4 -0.5 0.7 -1.2
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.3 -0.5 0.0 0.4
Illness, injury, bereavement, stress in last 2 years 1.4 1.7 5.1 -2.3 -0.0 -0.0
Medication: Aspirin 1.3 1.8 4.8 2.2 0.7 0.3
Supplements: Vitamin C 1.3 1.5 2.2 -1.5 -1.0 -1.2
Knee pain experienced in last month 0.3 0.5 1.5 1.2 -0.2 0.2
Hypertension (Self-reported) 0.5 1.4 2.1 -0.7 1.4 -1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.6 1.9 3.2 -1.8 -0.1 -1.6
Illnesses of father: Heart disease 0.2 0.3 0.5 0.7 -0.5 0.4
Illnesses of siblings: Diabetes 0.4 0.5 1.3 1.1 0.1 -0.3
Smoking status: Previous 0.8 1.2 2.9 0.7 -1.7 0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 0.6 -0.3 -0.7 0.7
Whole body fat-free mass 1.1 6.4 9.4 1.2 -3.1 2.9
Leg fat-free mass (right) 1.0 5.5 7.9 1.4 -2.8 2.5
Arm fat percentage (left) 2.7 11.0 19.2 1.9 -4.4 3.2
Average weekly red wine intake 0.9 1.3 3.4 1.9 -0.3 0.7
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.6 -0.8 -0.0 0.2
Mood swings 0.1 0.2 0.7 -0.2 -0.0 0.8
Loneliness, isolation 0.2 0.2 0.6 -0.1 0.8 -0.3
Long-standing illness, disability or infirmity 1.6 2.4 3.9 1.3 2.0 -1.3
Ever had bowel cancer screening 1.0 1.1 2.3 -1.5 0.3 -1.0
Diabetes diagnosed by doctor 1.2 1.9 4.9 2.2 0.2 0.9
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 1.2 1.1 0.0 1.1
Friendships satisfaction 0.8 1.0 2.0 0.9 -0.2 1.4
Qualifications: nursing, teaching 0.6 0.9 1.6 1.2 0.8 0.6
Commuting to job workplace: Walk 0.6 0.7 1.1 1.1 0.2 1.0
Eye problems/disorders: Cataract 3.5 4.1 9.1 -3.0 1.1 -1.4
Mouth/teeth dental problems: Mouth ulcers 0.0 0.0 0.0 -0.1 -0.0 0.2
Medication for cholesterol 0.5 0.7 1.6 -0.7 -1.3 0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 0.9 0.7 1.0 -0.3
Back pain experienced in last month 0.4 0.5 1.3 0.3 1.1 0.5
Mineral and other dietary supplements 0.1 0.2 0.2 -0.5 0.4 0.3
Breast cancer (self-reported) 0.3 0.3 0.5 0.7 -0.1 -0.7
Asthma (self-reported) 0.1 0.1 0.2 0.4 0.2 0.4
Osteoporosis (self-reported) 1.3 1.7 3.1 -1.3 0.3 -1.8
Osteoarthritis (self-reported) 0.1 0.1 0.2 0.3 0.1 -0.5
Medication: Aspirin 2.3 3.0 8.0 2.8 -0.2 1.0
Medication: Gliclazide 0.6 0.7 1.3 1.1 0.2 0.9
Illnesses of father: None of the above (group 1) 1.1 1.3 2.6 0.8 -0.9 1.6
Smoking status: Current 0.2 0.2 0.4 -0.1 -0.6 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.0 0.1 0.1 -0.3 0.2 0.3
Whole body water mass 1.1 6.5 9.5 1.2 -3.1 2.9
Leg predicted mass (right) 1.0 5.3 8.1 1.4 -2.8 2.5
Arm fat mass (left) 2.4 10.0 18.1 1.4 -4.2 3.2
Number of self-reported non-cancer illnesses 0.3 0.6 1.4 1.2 -0.4 0.5
Average weekly champagne plus white wine intake 0.4 0.5 1.4 -0.1 1.2 -0.1
Miserableness 0.3 0.4 1.2 -0.2 0.3 1.1
Guilty feelings 0.2 0.3 0.5 0.0 -0.7 0.6
Wears glasses or contact lenses 1.4 1.6 4.4 -0.5 2.1 -0.2
Ever taken oral contraceptive pill 2.1 2.4 3.5 -1.2 1.5 -1.9
Hearing aid user 0.5 0.5 0.8 -0.6 0.9 -0.7
Mother’s age at death 0.5 0.7 1.2 -1.1 0.9 0.2
Financial situation satisfaction 1.0 1.2 3.5 -1.9 -0.1 0.2
Tinnitus: Yes, now most or all of the time 0.4 0.5 1.2 0.4 -1.1 -0.3
Commuting to job workplace: Public transport 1.2 1.4 3.4 1.8 0.8 -0.5
Eye problems/disorders: Glaucoma 0.9 1.0 1.5 -1.2 0.7 -1.0
Medication: Blood pressure 1.4 2.6 5.1 -0.1 2.2 -1.7
Pain type(s) experienced in last month: Hip pain 1.0 1.3 2.1 0.2 -1.3 1.5
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.5 0.7 -0.2 -0.4
High cholesterol (Self-reported) 0.5 0.8 1.5 0.6 -0.8 -1.2
Medication: Bendroflumethiazide 0.2 0.3 0.9 -0.2 -0.2 -1.0
Medication: Paracetamol 0.6 0.9 1.9 -1.4 0.8 -0.5
Medication: Lisinopril 1.2 1.6 3.3 1.8 1.0 -0.6
Medication: Atorvastatin 3.9 4.8 8.4 2.9 -0.3 2.4
Illnesses of father: High blood pressure 2.7 3.3 5.2 -2.3 1.5 -1.6
Alcohol drinker status: Never 1.3 1.5 3.1 0.7 -1.0 1.8
Ever smoked 0.2 0.4 0.7 -0.3 -0.8 -0.7
Basal metabolic rate 1.4 7.7 11.6 1.3 -3.4 3.1
Leg fat percentage (left) 2.2 8.0 12.5 1.3 -3.5 3.1
Arm fat-free mass (left) 1.0 5.2 8.3 0.4 -2.9 2.7
Number of operations (self-reported) 1.0 1.4 3.4 1.8 -0.9 0.3
Average weekly beer plus cider intake 3.4 5.0 12.9 -0.5 -3.6 1.3
Irritability 0.4 0.7 1.0 -1.0 -0.9 0.5
Risk taking 0.5 0.7 1.3 -0.9 -1.1 -0.2
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.3 0.5 -0.1 0.1
Fractured/broken bones in last 5 years 0.3 0.4 0.9 -0.3 0.6 -0.9
Age started oral contraceptive pill 0.0 0.0 0.0 -0.2 -0.1 0.2
Diastolic blood pressure, automated reading 1.9 5.8 8.8 -1.5 2.5 -3.0
Ever depressed for a whole week 0.3 0.4 0.7 -0.0 0.7 -0.8
Unable to work because of sickness or disability 0.4 0.6 0.9 -0.1 -0.9 -0.9
Commuting to job workplace: Cycle 0.2 0.2 0.6 -0.0 -0.7 -0.4
Myopia 2.6 3.8 8.4 -0.7 2.9 -1.6
Vascular/heart problems diagnosed by doctor 0.7 1.9 2.7 0.6 -1.7 1.6
Cholesterol lowering medication 0.5 0.8 1.4 1.2 -0.0 -1.0
Medication: Omeprazole (e.g. Zanprol) 2.1 2.5 6.3 -1.0 -2.5 -0.3
Pain experienced in last month 0.1 0.1 0.1 0.4 0.3 -0.4
Supplements: Calcium 1.0 1.0 2.8 -0.3 -1.7 -0.5
Basal cell carcinoma (self-reported) 0.2 0.2 0.3 0.6 0.4 0.2
Heart attack/myocardial infarction (self-reported) 2.5 3.3 5.7 2.4 -0.6 2.0
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.1 1.1 0.2 0.1
Heart disease (siblings) 0.4 0.5 1.6 1.2 0.1 -0.0
Alcohol drinker status: Previous 0.5 0.6 1.1 1.1 0.0 -0.8
Pack years of smoking 0.9 1.3 2.3 0.7 -1.5 1.1
Impedance of whole body 0.4 1.9 4.9 -0.4 2.2 -0.9
Leg fat mass (left) 2.6 10.3 16.8 1.4 -4.1 3.5
Arm predicted mass (left) 1.2 5.9 9.7 0.5 -3.1 2.8