Hub : Genes

SNX2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.2240	0.0530	2.5e-07	0.062	NA	0.102	NA	0.058	2.1e-05	NA	4.4e-08	NA	3.5e-05
2	NTR	Blood	0.0182	0.0076	3.8e-03	0.011	0.005	0.010	0.006	0.010	1.3e-04	5.2e-03	1.8e-04	0.0032	2.3e-04
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0335	0.0202	8.0e-03	0.008	0.009	0.013	NA	0.013	3.8e-02	2.7e-02	1.3e-02	NA	1.1e-02
4	TCGA	Thyroid Carcinoma	0.0690	0.0320	4.8e-05	0.015	0.054	0.040	NA	0.038	1.2e-02	5.6e-06	8.2e-05	NA	1.2e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.2	0.3	1.1	0.4	-0.1	1.1	-0.2
Bipolar Disorder or Schizophrenia	0.1	0.2	0.4	0.4	-0.7	0.4	0.1
Depressed Affect (Nagel 2018)	0.2	0.3	0.9	-0.7	-0.2	-0.1	0.9
Depression (Nagel 2018)	1.5	2.3	4.4	-2.1	-1.6	0.9	1.2
Intelligence (Savage-Jansen 2018)	0.3	1.1	2.5	-0.4	-1.6	1.3	0.0
Neuroticism (Nagel 2018)	0.3	0.7	2.1	0.6	0.6	-1.5	0.2
Schizophrenia (2018)	0.1	0.2	0.5	0.2	-0.7	-0.4	0.2
Schizophrenia vs Biploar Disorder	0.5	0.6	1.4	-0.6	-0.7	-1.2	-0.5
Worry (Nagel 2018)	1.0	2.1	5.5	0.8	1.5	-2.3	-0.4
Alzheimer’s Disease (in mother)	0.3	0.3	1.1	-0.1	-1.0	0.3	-0.3
Alzheimer’s Disease (in father)	0.1	0.1	0.1	0.1	-0.3	0.1	-0.4
Alzheimer’s Disease (including proxy)	0.2	0.3	0.5	0.1	-0.7	-0.6	-0.7
Crohns Disease (2017)	1.0	2.2	3.2	-1.1	-1.3	1.6	1.8
Irritable Bowel Disease (IBD)	0.1	0.1	0.4	0.3	0.6	0.1	0.3
Ulcerative Colitis (UC)	0.5	0.9	2.3	0.7	1.5	-0.7	-0.5
Major Depression (MDD)	0.6	0.7	2.2	0.7	-0.1	0.2	1.5
Reaction Time	0.2	0.3	0.5	0.1	0.7	-0.7	-0.7
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.4	0.6	-0.0	-0.1	-0.6
Breast Cancer	0.9	2.3	5.5	0.7	1.0	-1.5	-2.3
Ovarian Cancer	0.4	0.6	1.3	1.1	0.4	-0.8	-0.4
Prostate Cancer	0.6	0.8	1.2	-0.8	-0.4	1.1	1.1
Age at First Birth	0.3	0.5	1.3	0.5	-0.6	0.1	-1.1
Bipolar Disorder (2011)	0.3	0.3	0.6	-0.4	-0.8	0.4	0.4
Body Mass Index (BMI) (2010)	0.7	0.9	3.2	-0.2	0.5	-1.8	-0.3
Coronary Artery Disease (CAD)	0.6	0.7	1.3	-0.5	1.1	-1.1	0.2
Crohns Disease (2012)	1.1	1.8	3.7	-1.1	-1.2	1.9	0.9
Mean Putamen Volume	0.5	0.6	1.6	-1.3	0.2	-0.7	-0.3
Fasting Glucose	0.7	0.9	1.8	0.4	0.0	-1.2	-1.4
HbA1C	2.7	3.0	7.3	-2.7	-1.5	0.5	1.4
HDL Cholesterol	0.5	0.9	1.8	-1.4	-1.0	0.2	0.8
LDL Cholesterol	0.4	0.6	1.7	-0.2	-0.3	-0.6	-1.3
Lupus	0.4	0.6	1.0	0.8	0.8	-0.1	1.0
Neuroticism (2016)	0.3	0.4	0.7	0.9	0.6	-0.7	-0.1
Primary Biliary Cirrhosis	0.6	0.8	1.9	-0.3	1.4	-0.9	0.7
Rheumatoid Arthritis	1.1	1.5	2.5	0.1	1.5	-1.6	-1.0
Schizophrenia (2014)	0.2	0.4	0.8	0.8	-0.9	0.2	0.5
Triglycerides	0.4	0.7	1.3	0.8	1.1	-0.8	-0.6
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.1	0.3	0.4	-1.1	-0.2
Ulcerative Colitis	0.4	0.5	0.9	0.9	0.7	-0.7	-0.4
Blood Eosinophil Count	0.4	2.9	6.6	0.4	1.6	-1.4	-2.6
Blood Platelet Count	0.5	5.3	8.2	1.4	2.1	-2.9	-2.5
Blood Red Count	0.0	0.3	0.8	0.2	0.7	-0.1	-0.9
Blood White Count	0.7	5.2	9.6	-1.0	1.4	-2.9	-3.1
Heel T-Score	0.8	6.2	9.9	-1.0	-3.1	3.1	2.0
BMI	0.6	3.6	6.7	0.0	2.5	-2.6	-1.2
Height	0.1	1.9	6.1	-2.5	1.0	0.5	0.6
Waist Hip Ratio (WHR)	0.4	1.7	3.8	-1.3	-1.0	0.3	2.0
Systolic Blood Pressure	1.0	5.2	11.9	-3.4	-0.8	-0.4	2.8
Smoking Status	0.3	0.7	2.0	-1.4	-0.2	0.1	0.8
Allergy or Eczema	0.1	0.3	0.4	-0.5	0.6	-0.7	-0.6
Cardiovascular Disease	0.7	2.4	5.9	-1.0	1.7	-2.4	0.1
Hypothyroidism (self reported)	0.5	1.1	2.4	1.5	-0.0	0.7	-1.3
Respiratory disease	0.3	0.6	1.8	-1.3	-0.7	-0.1	-0.3
Type 2 Diabetes (T2D) (2018)	2.2	4.2	7.3	1.7	2.7	-2.5	-0.3
Lung FEV1/FVC ratio	0.1	0.3	0.6	-0.8	-0.2	0.7	-0.0
Lung FVC	1.8	9.0	14.9	-0.6	-2.5	3.9	3.8
Neuroticism	0.5	1.1	2.8	0.2	1.1	-1.7	0.7
Chronotype (morning person)	0.3	0.7	1.8	-1.3	-0.7	0.5	0.7
Hair Pigment	0.1	3.8	5.0	2.2	2.1	-1.7	-1.7
Tanning	0.0	0.6	1.0	0.6	0.7	-1.0	-0.6
Hand grip strength (left)	0.5	1.4	2.3	-1.5	-1.1	1.1	0.9
Number of treatments/medications taken	1.2	2.2	6.2	-0.6	1.3	-2.5	-0.7
Average weekly spirits intake	5.4	6.8	9.6	1.1	3.1	-2.8	-2.9
Sensitivity / hurt feelings	5.1	8.7	15.8	2.2	3.3	-4.0	-1.7
Frequency of depressed mood in last 2 weeks	0.6	0.9	2.6	-1.6	-0.6	-0.7	0.3
Hearing difficulty/problems: Yes	1.6	2.4	5.9	1.0	1.6	-2.4	0.0
Relative age of first facial hair	1.1	2.2	4.0	1.7	1.2	-2.0	-0.5
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.1	-0.4	0.3	-0.1	-0.2
Ever used hormone-replacement therapy (HRT)	0.4	0.6	1.2	0.3	-0.1	0.9	1.1
Ever had hysterectomy (womb removed)	0.7	0.8	1.7	-1.2	-0.1	-0.4	1.3
Systolic blood pressure, automated reading	0.5	1.5	4.2	-2.1	0.4	-1.1	0.6
Eye problems/disorders: Diabetes related eye disease	1.3	1.5	2.7	-1.3	1.2	-1.6	0.5
Angina	0.1	0.1	0.3	0.1	0.2	-0.0	0.5
Medication for hormone replacement therapy	0.2	0.3	0.5	0.6	-0.3	0.7	0.3
Vitamin and mineral supplements	0.1	0.2	0.6	-0.0	0.8	0.0	0.4
Supplements: Zinc	0.8	0.9	2.2	1.5	0.8	-0.9	-0.1
Medication: Co-codamol	0.6	0.7	2.1	0.2	0.1	-1.4	-0.7
Medication: Metformin	0.7	1.0	1.5	0.7	1.2	-1.2	0.5
Diabetes (father)	0.5	0.6	1.6	-1.3	-0.8	0.4	-0.1
Diabetes (mother)	1.3	1.7	4.9	-0.4	0.4	-1.2	-2.2
Severe depression (siblings)	0.5	0.5	1.4	0.8	0.2	-1.2	0.1
Pack years adult smoking proportion	0.2	0.3	0.5	-0.7	-0.7	-0.6	0.1
Impedance of leg (right)	0.6	2.7	3.4	1.4	-1.9	1.6	1.6
Leg fat-free mass (left)	0.3	1.4	2.6	-1.4	1.6	-0.9	0.2
Trunk fat percentage	0.5	1.8	4.5	0.7	2.1	-1.5	-0.2
Hand grip strength (right)	1.4	3.7	5.5	-1.5	-2.1	2.3	1.7
Townsend deprivation index at recruitment	0.4	0.5	1.7	0.5	0.3	-1.3	-0.2
Current tobacco smoking	1.1	1.7	2.9	-1.7	-1.5	1.2	0.5
Average weekly fortified wine intake	1.1	1.3	2.3	0.9	1.5	-1.2	-0.7
Maternal smoking around birth	0.3	0.4	0.6	-0.8	-0.7	0.7	-0.2
Fed-up feelings	0.3	0.5	1.5	-0.2	0.2	-0.6	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	1.8	-1.3	-1.4	0.7	0.9
Relative age voice broke	2.7	4.1	5.2	2.2	1.5	-2.3	-2.0
Taking other prescription medications	1.8	2.8	7.6	0.2	1.5	-2.8	-1.1
Age when periods started (menarche)	1.2	3.0	7.4	0.4	1.3	-2.7	-1.6
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.6	-0.6	-0.3	0.6	0.8
Heel bone mineral density (BMD) T-score, automated (left)	1.8	4.0	6.2	-1.2	-2.5	2.3	1.7
Tinnitus: Yes, but not now, but have in the past	4.3	4.5	10.1	-1.5	-1.8	1.6	3.2
Qualifications: CSEs or equivalent	0.7	1.0	2.4	-0.2	0.6	-1.0	-1.5
Serious illness, injury or assault to yourself	0.1	0.1	0.2	0.1	-0.2	-0.3	-0.4
High blood pressure	0.8	2.2	4.7	-1.1	1.5	-2.2	0.7
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.1	-0.2	0.1	-0.7	-1.0
Multivitamins +/- minerals	0.9	1.2	2.7	0.9	0.2	-1.1	-1.6
Stomach or abdominal pain in last month	1.3	1.7	2.5	-1.3	-1.2	1.0	1.6
Supplements: Glucosamine	0.4	0.5	0.9	0.9	0.5	0.4	0.9
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	-0.7	-0.4	0.2	0.0
Medication: Atenolol	0.4	0.5	1.3	-0.4	0.0	0.6	1.1
Medication: Levothyroxine sodium	0.4	0.6	1.2	0.3	-1.1	1.0	-0.5
Sitting height	0.9	6.3	10.7	-2.0	-1.4	2.9	3.3
Chronic bronchitis/emphysema (father)	3.3	3.8	8.4	0.6	1.3	-2.9	-2.2
High blood pressure (mother)	0.3	0.4	1.5	-0.1	-0.1	0.1	1.2
Body mass index (BMI)	0.4	1.9	3.7	-0.4	1.9	-1.7	-0.9
Impedance of leg (left)	0.5	2.5	2.8	1.7	-1.7	1.6	1.4
Leg predicted mass (left)	0.3	1.3	2.5	-1.4	1.6	-0.8	0.2
Trunk fat mass	0.4	1.8	5.0	0.2	2.2	-1.5	-0.1
Waist circumference	0.3	0.9	2.0	-0.9	1.4	-1.0	-0.1
Number of incorrect matches in round	0.2	0.3	1.1	0.5	1.0	0.0	-0.0
Past tobacco smoking	1.3	2.4	4.8	0.1	-1.8	2.2	1.2
Alcohol usually taken with meals	0.3	0.4	0.9	0.9	0.4	-0.3	-0.7
Nervous feelings	1.4	2.6	5.9	1.6	1.3	-2.4	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.7	-1.3	-0.6	-0.6	-0.1
Hearing difficulty/problems with background noise	1.2	1.9	3.1	1.7	1.4	-1.6	-0.2
Hair/balding pattern: Pattern 2	3.1	4.0	7.3	1.0	2.4	-2.7	-1.3
Had menopause	0.8	1.0	1.7	-0.5	-1.1	1.0	1.3
Had other major operations	2.1	2.5	5.0	-0.8	1.4	-2.2	-1.6
Forced vital capacity (FVC)	2.7	10.2	16.3	-0.9	-2.8	4.0	4.0
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	2.7	-1.4	-1.7	1.6	1.3
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.7	0.8	0.5	-0.2	0.5
Qualifications: None of the above	0.5	1.1	2.8	-0.7	0.8	-1.7	0.7
Financial difficulties in last 2 years	2.2	3.0	3.9	2.0	1.9	-1.8	-1.1
Mouth/teeth dental problems	0.5	0.8	1.8	-0.3	-0.9	1.3	0.6
Heart attack	0.2	0.2	0.4	-0.7	0.0	0.4	0.4
Allergy	0.1	0.2	0.7	0.8	0.3	0.4	0.2
Pain all over the body in last month	0.1	0.1	0.1	-0.3	0.4	-0.3	0.4
Diabetes (self-reported)	2.2	3.4	6.8	1.7	2.6	-1.8	-0.9
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.8	0.7	0.6	-0.1	-0.9
Medication: Ramipril	1.7	2.2	6.0	-1.3	-0.8	0.7	2.4
Medication: Simvastatin	0.1	0.1	0.2	-0.4	-0.4	0.3	0.3
Fluid intelligence score	0.2	0.5	1.1	1.0	-0.0	0.2	-0.9
Illnesses of siblings	0.6	0.9	2.1	0.3	-1.4	1.1	0.4
Neuroticism score	1.3	2.8	7.2	0.7	1.8	-2.7	-0.1
Weight	0.3	1.3	3.1	-0.9	1.8	-1.0	0.1
Impedance of arm (right)	0.3	1.4	2.2	1.5	-0.7	1.2	1.1
Arm fat percentage (right)	0.4	1.6	3.8	0.4	2.0	-1.5	-0.4
Trunk fat-free mass	0.2	1.0	3.1	-1.8	1.0	-0.1	0.1
Hip circumference	0.5	2.0	5.3	0.0	2.3	-1.5	-0.6
Time employed in main current job	6.9	7.9	8.8	2.9	3.0	-2.8	-2.6
Alcohol intake versus 10 years previously	8.7	13.0	21.2	-4.6	-3.8	2.9	2.9
Father’s age at death	0.7	0.9	3.4	-1.8	-0.4	0.2	0.2
Worrier / anxious feelings	3.2	6.1	17.0	-0.4	2.3	-4.1	-1.4
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.8	0.1	0.6	-0.9	0.8
Falls in the last year	0.4	0.5	1.0	-1.0	-0.2	0.4	1.0
Hair/balding pattern: Pattern 3	0.4	0.6	1.7	0.5	0.7	1.3	0.2
Number of live births	0.9	1.3	3.9	-2.0	-0.7	0.6	0.7
Forced expiratory volume in 1-second (FEV1)	2.5	8.5	15.3	-0.8	-2.6	3.9	3.4
Pulse rate	0.1	0.2	0.3	0.3	-0.6	-0.2	-0.5
Happiness	0.3	0.4	1.0	-0.2	-0.1	-1.0	0.7
Noisy workplace	0.3	0.3	0.5	-0.6	0.2	-0.6	0.7
Qualifications: A levels/AS levels or equivalent	0.9	2.0	3.7	-0.9	-1.4	1.9	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.7	0.0	-1.3	0.9	0.3
Mouth/teeth dental problems: Dentures	0.0	0.1	0.1	0.4	0.2	0.0	0.3
Asthma	0.4	0.8	2.4	-1.5	-1.0	-0.0	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	4.2	-2.0	-0.4	-0.2	0.3
Medication: Cholesterol lowering	0.7	1.0	2.2	0.3	1.1	-1.5	-0.7
Depression (self-reported)	1.2	1.4	5.0	-0.4	-0.0	-0.7	-2.2
Medication: Lansoprazole	2.9	3.3	8.6	1.0	1.9	-2.9	-0.1
Prospective memory result	0.3	0.3	1.2	0.4	-0.1	-0.1	1.1
Lung cancer (father)	0.3	0.3	0.5	0.5	-0.4	0.6	0.7
Illnesses of mother	0.1	0.1	0.3	0.1	0.3	-0.3	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	2.7	8.7	18.4	-1.1	-2.5	4.3	3.0
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	-0.7	0.4	-0.1	0.3
Impedance of arm (left)	0.4	1.9	2.6	1.6	-1.0	1.4	1.4
Arm fat mass (right)	0.3	1.3	3.4	-0.2	1.9	-1.3	-0.3
Trunk predicted mass	0.2	1.0	2.8	-1.7	1.0	-0.1	0.1
Standing height	0.2	2.4	5.6	-1.4	-0.2	1.5	2.4
Length of working week for main job	0.3	0.4	0.8	0.3	0.9	-0.7	0.5
Exposure to tobacco smoke at home	1.4	1.6	4.0	0.9	0.9	-2.0	-0.7
Breastfed as a baby	0.2	0.2	0.6	-0.8	-0.1	0.5	0.2
Tense / ‘highly strung’	0.5	0.9	2.7	0.4	0.8	-1.6	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.9	0.3	0.6	-0.9	-0.3
Hair/balding pattern: Pattern 4	10.9	26.5	45.0	1.5	5.1	-6.7	-5.7
Birth weight of first child	1.9	3.5	4.9	0.4	-2.0	2.2	2.2
Peak expiratory flow (PEF)	1.8	4.2	6.1	-1.4	-1.9	2.5	2.3
Pulse wave reflection index	0.4	0.4	1.4	-0.5	1.2	-0.4	-0.1
Ever highly irritable/argumentative for 2 days	1.2	1.5	3.4	-0.1	1.1	-1.8	-1.2
Loud music exposure frequency	0.4	0.5	1.2	-1.1	-0.3	-0.7	-0.1
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.5	1.6	-0.3	0.7	0.2
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.4	0.5	-0.5	0.0	0.6
Blood clot in the leg (DVT)	0.7	0.9	1.7	1.3	1.1	-0.9	0.1
Medication: Paracetamol	0.8	1.3	2.8	-1.7	-1.1	-1.0	-0.4
Headache pain in last month	0.4	0.7	1.3	-0.9	0.5	-0.7	1.1
Medication for cholesterol, blood pressure or diabetes	2.5	4.1	10.1	-0.6	-2.2	3.2	1.0
Glaucoma (self-reported)	0.3	0.3	0.7	-0.1	0.6	-0.8	-0.3
Gout (self-reported)	0.3	0.4	1.3	-0.2	0.2	0.4	1.1
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	3.2	1.8	-0.2	0.7	-1.4
Medication: Amlodipine	0.2	0.3	0.5	0.2	0.4	-0.7	0.6
Medication: Ventolin 100micrograms inhaler	0.8	1.0	2.1	-1.5	-0.7	0.5	1.0
Birth weight	1.7	3.7	4.5	-2.1	-1.8	2.1	1.6
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.4	-1.2	-0.5	0.3	-0.9
High blood pressure (siblings)	0.4	0.6	1.3	-0.6	1.1	-0.8	0.2
Forced vital capacity (FVC), Best measure	2.0	7.4	16.0	-0.4	-2.1	4.0	3.0
Body fat percentage	0.4	1.5	3.6	0.7	1.9	-1.4	-0.2
Leg fat percentage (right)	0.2	0.7	1.5	0.4	1.2	-1.0	0.0
Arm fat-free mass (right)	0.2	1.1	2.9	-1.7	1.1	-0.5	0.3
Exposure to tobacco smoke outside home	0.2	0.3	0.7	0.4	-0.4	-0.1	0.8
Comparative body size at age 10	0.6	1.8	2.8	-1.7	-1.2	1.7	-0.2
Number of full brothers	1.1	1.4	2.9	1.0	1.1	-1.7	0.6
Worry too long after embarrassment	1.3	2.2	4.0	0.9	2.0	-2.0	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.5	-0.0	-0.4	0.5	0.7
Wheeze or whistling in the chest in last year	0.5	1.0	1.8	-1.2	0.3	-1.4	0.6
Number of children fathered	0.2	0.2	0.8	0.1	0.2	-0.1	0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	2.9	0.7	0.9	-1.3	-1.7
Age at first live birth	0.7	1.2	4.3	2.1	0.8	-0.0	-0.0
Pulse wave peak to peak time	0.1	0.1	0.2	0.5	-0.3	-0.0	-0.2
Health satisfaction	0.4	0.5	1.5	-0.4	-0.3	-0.4	1.2
Shortness of breath walking on level ground	0.3	0.4	0.8	-0.9	-0.3	-0.7	0.1
Qualifications: College or University degree	0.1	0.2	0.6	0.8	0.4	0.2	-0.4
Eye problems/disorders: None of the above	0.6	0.7	0.8	0.9	0.7	-0.8	-0.8
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.7	0.6	0.8	-0.5	-0.4
Emphysema/chronic bronchitis	0.4	0.4	0.6	0.4	0.8	-0.8	0.4
Medication for pain relief, constipation, heartburn	0.7	1.1	2.4	1.6	-0.1	1.4	0.3
Neck or shoulder pain in last month	0.2	0.3	0.9	-0.3	0.5	-1.0	0.2
Medication: Blood pressure	0.4	0.7	1.5	-0.2	0.9	-1.2	0.8
Angina (self-reported)	0.1	0.1	0.2	-0.2	0.1	0.0	0.5
Migraine (self-reported)	0.3	0.4	0.7	-0.7	-0.4	-0.8	0.5
Medication: Ibuprofen	0.9	1.0	3.1	-1.7	0.1	-0.3	1.0
Medication: Allopurinol	0.3	0.5	1.0	0.8	1.0	-0.4	0.1
Medication: Omeprazole	0.9	1.1	2.3	-1.5	-0.9	0.3	1.1
Medication: Seretide 50 evohaler	0.2	0.2	0.4	0.1	-0.6	0.2	0.6
Mean time to correctly identify matches	0.5	1.0	1.1	0.7	1.1	-1.0	-1.1
Heart disease (mother)	0.6	0.7	1.6	-0.4	-0.9	1.3	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.6	2.5	-1.1	-1.6	1.5	0.7
Whole body fat mass	0.4	1.5	4.2	0.1	2.0	-1.4	-0.3
Leg fat mass (right)	0.2	0.8	2.2	0.1	1.5	-0.9	0.2
Arm predicted mass (right)	0.2	1.2	2.9	-1.7	1.2	-0.6	0.3
Pulse rate, automated reading	1.0	3.4	7.1	-1.2	-2.7	1.6	1.6
Alcohol intake frequency.	0.9	2.0	4.0	-0.0	-2.0	1.7	1.1
Comparative height size at age 10	0.4	2.2	4.1	-1.7	-0.9	1.0	2.0
Number of full sisters	1.1	1.4	3.0	0.2	1.6	-1.7	-0.1
Suffer from ‘nerves’	0.2	0.3	0.4	-0.6	-0.1	-0.6	0.6
Overall health rating	0.6	1.4	4.1	-0.9	0.8	-2.0	-0.1
Chest pain or discomfort	0.4	0.5	1.0	0.5	0.4	-0.8	-1.0
Had major operations	1.2	1.4	2.3	1.5	1.5	-0.7	-0.9
Age at last live birth	0.2	0.2	0.6	0.1	-0.8	0.5	-0.1
Family relationship satisfaction	0.4	0.5	1.1	0.4	0.0	-1.0	0.8
Leg pain on walking	0.2	0.3	0.7	0.4	0.5	-0.3	0.8
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	2.9	-0.7	1.0	-1.7	-1.1
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	-0.2	0.3	-0.3	-0.6
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.9	-0.1	1.0	-0.2	0.1
Medication: Aspirin	0.3	0.4	0.8	0.1	0.9	-0.9	-0.4
Supplements: Vitamin C	2.1	2.5	3.1	-1.6	-1.8	1.7	1.3
Knee pain experienced in last month	1.6	2.5	3.3	0.8	1.8	-1.8	-1.7
Hypertension (Self-reported)	0.8	2.3	4.9	-1.2	1.7	-2.2	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	2.5	1.5	1.3	-1.6	1.2
Illnesses of father: Heart disease	1.2	1.6	3.1	-1.1	-0.2	1.5	1.8
Illnesses of siblings: Diabetes	2.6	3.2	4.6	1.7	1.7	-2.1	-1.6
Smoking status: Previous	1.7	2.6	4.9	0.0	2.2	-2.0	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.0	0.1	-0.3	0.1	0.2	0.0
Whole body fat-free mass	0.2	1.2	3.0	-1.7	1.3	-0.4	0.2
Leg fat-free mass (right)	0.3	1.4	2.7	-1.5	1.6	-0.9	-0.1
Arm fat percentage (left)	0.4	1.4	3.4	0.4	1.8	-1.5	-0.4
Average weekly red wine intake	0.5	0.7	1.3	1.1	1.0	-0.7	-0.3
Handedness (chirality/laterality): Left-handed	1.3	1.6	3.1	-0.7	-1.5	0.8	1.7
Mood swings	0.9	1.7	5.1	-0.1	1.3	-2.3	0.2
Loneliness, isolation	0.2	0.3	0.4	0.6	-0.6	-0.5	0.6
Long-standing illness, disability or infirmity	1.7	2.6	6.0	1.0	1.6	-2.5	-0.9
Ever had bowel cancer screening	1.2	1.4	2.4	0.6	1.2	-1.6	-1.1
Diabetes diagnosed by doctor	2.2	3.6	6.9	1.7	2.6	-2.0	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	4.2	-2.0	-1.2	1.1	0.6
Friendships satisfaction	0.2	0.3	0.5	0.5	0.2	-0.7	0.6
Qualifications: nursing, teaching	0.9	1.4	3.2	1.1	0.6	-0.7	-1.8
Commuting to job workplace: Walk	0.1	0.1	0.3	-0.1	0.1	-0.5	-0.5
Eye problems/disorders: Cataract	0.5	0.6	1.3	-0.6	-0.7	1.2	0.5
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.0	-1.7	0.3	-1.4	-0.0
Medication for cholesterol	1.4	2.1	2.6	1.5	1.6	-1.5	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.5	0.5	-0.7	0.2	0.7
Back pain experienced in last month	0.6	0.8	2.3	-0.8	0.4	-1.5	0.4
Mineral and other dietary supplements	1.0	1.4	2.4	-1.4	-1.6	1.1	-0.1
Breast cancer (self-reported)	0.5	0.6	1.0	-0.7	-0.6	1.0	0.8
Asthma (self-reported)	0.5	0.9	3.0	-1.7	-0.9	-0.1	-0.1
Osteoporosis (self-reported)	0.1	0.2	0.3	-0.6	-0.1	-0.5	0.1
Osteoarthritis (self-reported)	2.3	2.9	4.7	1.6	1.9	-2.2	-1.0
Medication: Aspirin	0.3	0.5	0.8	0.5	0.9	-0.8	-0.2
Medication: Gliclazide	1.1	1.2	2.2	0.8	-0.5	1.4	1.5
Illnesses of father: None of the above (group 1)	0.6	0.8	1.4	0.8	-1.2	0.9	0.5
Smoking status: Current	0.8	1.3	2.6	-1.6	-1.3	0.9	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	6.5	-0.2	-1.1	2.5	1.9
Whole body water mass	0.2	1.3	3.2	-1.8	1.3	-0.4	0.2
Leg predicted mass (right)	0.3	1.5	3.0	-1.4	1.7	-0.9	-0.0
Arm fat mass (left)	0.3	1.3	3.4	-0.3	1.9	-1.3	-0.2
Number of self-reported non-cancer illnesses	1.1	1.9	4.7	0.1	1.4	-2.2	-0.9
Average weekly champagne plus white wine intake	0.1	0.1	0.2	-0.4	-0.0	-0.3	0.3
Miserableness	0.5	0.8	1.6	0.7	0.7	-1.2	-0.8
Guilty feelings	0.5	0.7	1.2	1.0	0.6	-0.4	-1.1
Wears glasses or contact lenses	0.6	0.7	2.2	0.7	0.3	-0.2	-1.5
Ever taken oral contraceptive pill	3.5	3.9	7.4	2.7	2.3	-1.7	-0.4
Hearing aid user	2.7	3.0	5.4	1.0	2.3	-2.1	-1.1
Mother’s age at death	0.1	0.2	0.4	0.6	0.5	0.1	0.1
Financial situation satisfaction	1.3	1.6	2.9	1.7	0.9	-1.6	0.1
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.0	-0.4	-1.4	0.6	0.1
Commuting to job workplace: Public transport	0.2	0.2	0.4	0.1	-0.6	-0.0	-0.6
Eye problems/disorders: Glaucoma	0.2	0.3	0.6	-0.0	0.8	-0.7	0.1
Medication: Blood pressure	1.1	2.0	3.4	-1.7	-0.9	1.0	1.9
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.8	-0.8	-0.4	0.3	0.9
Supplements: Fish oil (including cod liver oil)	1.3	1.7	3.0	1.7	1.6	-0.9	-0.1
High cholesterol (Self-reported)	0.5	0.9	2.5	0.6	0.6	-1.6	-0.7
Medication: Bendroflumethiazide	0.5	0.7	2.2	-0.5	0.3	-0.5	1.5
Medication: Paracetamol	0.7	1.1	3.6	-1.9	-0.7	-0.6	0.1
Medication: Lisinopril	0.3	0.4	0.9	-0.7	-0.4	0.4	1.0
Medication: Atorvastatin	0.4	0.5	1.7	0.3	-0.0	-0.4	1.3
Illnesses of father: High blood pressure	2.0	2.4	6.7	-0.4	1.5	-2.6	-0.7
Alcohol drinker status: Never	0.3	0.3	0.4	-0.4	-0.5	0.6	0.6
Ever smoked	1.0	1.8	3.0	0.2	1.6	-1.7	-1.2
Basal metabolic rate	0.2	1.2	2.3	-1.5	1.5	-0.7	0.1
Leg fat percentage (left)	0.2	0.8	1.9	0.4	1.4	-1.0	-0.1
Arm fat-free mass (left)	0.2	1.0	2.0	-1.2	1.4	-0.7	0.0
Number of operations (self-reported)	0.3	0.5	1.3	-1.1	0.8	-0.3	0.0
Average weekly beer plus cider intake	0.6	0.9	2.5	-0.0	-0.6	0.9	1.6
Irritability	0.7	1.2	2.8	0.5	1.2	-1.7	-0.5
Risk taking	0.1	0.2	0.3	-0.2	0.3	0.6	0.5
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.8	0.9	0.8	-0.2	-0.1
Fractured/broken bones in last 5 years	0.2	0.3	0.4	-0.7	-0.5	0.2	0.6
Age started oral contraceptive pill	1.1	1.4	4.8	-0.2	-0.7	0.5	2.2
Diastolic blood pressure, automated reading	0.3	0.8	3.0	-1.7	-0.4	-0.2	0.0
Ever depressed for a whole week	0.5	0.6	1.3	1.1	0.4	-0.0	0.9
Unable to work because of sickness or disability	0.2	0.3	0.7	0.5	-0.8	0.0	-0.4
Commuting to job workplace: Cycle	1.0	1.2	2.2	1.2	1.5	-1.0	-0.0
Myopia	0.1	0.1	0.5	0.7	-0.0	-0.3	0.1
Vascular/heart problems diagnosed by doctor	0.7	1.9	4.1	0.7	-1.8	2.0	-0.3
Cholesterol lowering medication	0.2	0.3	0.5	0.1	-0.7	0.7	0.5
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.2	-1.1	-0.5	-0.6	0.7
Pain experienced in last month	0.5	0.9	1.6	1.0	-0.9	1.3	-0.3
Supplements: Calcium	0.4	0.5	0.9	1.0	0.6	-0.7	-0.2
Basal cell carcinoma (self-reported)	1.7	2.1	3.8	-1.9	-1.5	1.3	0.9
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.5	-0.7	-0.0	0.4	0.4
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.5	1.2	1.0	-0.8	0.2
Heart disease (siblings)	7.4	9.0	10.8	-3.1	-2.7	3.3	2.9
Alcohol drinker status: Previous	0.4	0.4	1.1	1.0	-0.6	0.0	-0.6
Pack years of smoking	0.1	0.2	0.5	-0.1	-0.4	-0.7	0.2
Impedance of whole body	0.5	2.7	3.6	1.6	-1.5	1.6	1.9
Leg fat mass (left)	0.3	1.0	3.0	0.1	1.7	-1.1	0.1
Arm predicted mass (left)	0.2	1.1	2.4	-1.5	1.3	-0.5	0.1