Hub : Genes

KIAA0922

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue (Female)	0.1269	0.0828	0.0850	-0.008	NA	-0.010	NA	-0.010	0.65000	NA	0.9700	NA	0.8400
2	GTEx	Heart Left Ventricle	0.2079	0.0794	0.0063	0.012	NA	-0.002	NA	0.012	0.07400	NA	0.4000	NA	0.0690
3	METSIM	Adipose	0.0460	0.0220	0.0190	0.021	0.006	0.001	0.007	0.006	0.00035	0.0330	0.2000	0.03	0.0420
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0879	0.0378	0.0068	0.008	0.008	0.013	NA	0.022	0.03500	0.0370	0.0120	NA	0.0015
5	TCGA	Brain Lower Grade Glioma	0.0623	0.0282	0.0019	0.013	0.020	0.022	NA	0.018	0.01100	0.0023	0.0013	NA	0.0036

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.3	0.4	2.0	-1.4	0.2	0.3	-0.2	-0.2
Bipolar Disorder or Schizophrenia	0.4	1.0	1.9	-1.3	-0.2	0.2	-1.4	-1.2
Depressed Affect (Nagel 2018)	0.4	0.8	2.1	0.1	0.3	1.3	0.1	1.5
Depression (Nagel 2018)	1.2	1.8	6.0	-0.3	2.4	1.7	0.3	-0.1
Intelligence (Savage-Jansen 2018)	0.4	1.4	3.7	-0.1	-1.9	-1.5	0.8	0.5
Neuroticism (Nagel 2018)	0.6	1.5	6.2	-0.5	-0.3	0.7	0.6	2.5
Schizophrenia (2018)	0.5	1.0	2.5	-0.5	-0.4	0.0	-1.6	-1.4
Schizophrenia vs Biploar Disorder	0.8	1.1	3.0	-0.3	1.4	0.4	-0.0	-1.7
Worry (Nagel 2018)	1.0	2.0	4.9	-0.6	-0.6	1.2	1.8	2.2
Alzheimer’s Disease (in mother)	1.1	1.3	5.3	-0.6	-0.6	0.2	2.3	0.6
Alzheimer’s Disease (in father)	1.0	1.1	3.7	-0.6	1.9	0.1	-0.2	-1.2
Alzheimer’s Disease (including proxy)	0.6	0.9	3.7	-0.6	0.6	-0.3	1.9	-0.2
Crohns Disease (2017)	0.5	1.0	4.1	2.0	-0.4	0.8	0.5	-0.1
Irritable Bowel Disease (IBD)	0.4	0.9	2.5	1.6	-1.2	-0.2	0.6	0.6
Ulcerative Colitis (UC)	0.5	0.9	1.8	0.9	-0.8	-0.3	1.0	1.4
Major Depression (MDD)	0.3	0.4	1.1	0.4	-0.0	0.1	0.9	1.1
Reaction Time	0.3	0.7	2.3	-0.8	0.1	1.5	-0.5	-0.1
Verbal and Numeric Reasoning (VNR)	0.8	1.8	5.5	-1.0	-0.9	-2.3	1.2	0.4
Breast Cancer	0.4	1.0	2.0	-1.3	0.8	1.4	0.7	0.2
Ovarian Cancer	1.2	1.6	4.3	-0.5	2.1	0.6	0.9	-1.6
Prostate Cancer	0.5	0.7	1.4	1.2	-1.0	-0.2	-0.5	0.9
Age at First Birth	0.9	1.4	2.1	-1.4	-1.4	0.0	1.2	1.2
Bipolar Disorder (2011)	0.7	0.7	3.6	-1.9	0.0	0.3	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.6	1.0	0.9	0.5	1.0	-0.4	-1.0
Coronary Artery Disease (CAD)	0.9	1.1	3.9	1.0	0.0	2.0	0.6	-0.4
Crohns Disease (2012)	0.3	0.5	1.1	0.6	-1.1	-0.7	-0.2	0.6
Mean Putamen Volume	0.5	0.6	1.8	-0.1	0.5	-0.7	0.8	-1.3
Fasting Glucose	0.3	0.3	0.7	-0.1	-0.6	-0.8	0.2	-0.8
HbA1C	1.0	1.1	3.5	-0.3	-1.9	0.0	-1.1	0.8
HDL Cholesterol	2.0	3.4	4.7	-2.0	-2.1	-1.2	1.6	2.2
LDL Cholesterol	0.7	1.1	4.0	-0.0	1.1	2.0	-0.3	-0.6
Lupus	1.0	1.5	3.4	-1.9	-0.5	-1.7	0.9	0.7
Neuroticism (2016)	0.3	0.5	1.0	-0.6	-0.9	-0.4	0.3	1.0
Primary Biliary Cirrhosis	0.9	1.3	3.8	-0.2	-0.5	-2.0	0.4	1.5
Rheumatoid Arthritis	0.6	0.8	2.3	-1.5	0.5	-0.0	-1.1	-0.5
Schizophrenia (2014)	0.5	1.1	2.4	-1.6	0.1	-0.4	-1.5	-0.6
Triglycerides	0.8	1.2	1.6	-1.3	1.0	1.2	-1.3	-0.8
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.2	-1.5	0.0	-0.6	-1.2	-1.0
Ulcerative Colitis	0.0	0.1	0.2	0.0	0.3	-0.1	-0.4	-0.1
Blood Eosinophil Count	0.3	2.0	5.6	2.4	-0.3	-0.2	1.9	0.7
Blood Platelet Count	0.1	1.1	2.6	0.5	-1.0	-0.4	1.2	1.6
Blood Red Count	0.5	4.6	14.6	-2.1	-2.0	-0.3	0.1	3.8
Blood White Count	0.2	1.2	4.4	0.1	-2.1	-0.3	1.2	-0.2
Heel T-Score	0.1	0.9	2.2	-0.3	-1.4	-1.5	0.2	-0.4
BMI	0.6	3.6	6.8	1.8	2.3	1.2	1.0	-2.6
Height	0.2	3.1	5.6	-1.2	1.7	2.2	-0.8	-2.4
Waist Hip Ratio (WHR)	0.6	2.9	6.5	-1.5	-1.8	-1.0	1.2	2.5
Systolic Blood Pressure	0.2	1.0	2.5	-1.6	-0.5	0.8	0.9	0.8
Smoking Status	0.3	0.7	1.4	0.7	1.2	0.1	-0.6	-1.1
Allergy or Eczema	1.9	5.0	14.7	1.4	-2.4	-1.5	-0.3	3.8
Cardiovascular Disease	0.5	1.8	5.2	-0.3	-0.1	2.3	1.9	-0.5
Hypothyroidism (self reported)	0.6	1.5	7.1	-0.2	-0.5	-0.1	-0.1	2.7
Respiratory disease	0.2	0.5	0.9	-0.4	0.5	0.8	-1.0	-0.9
Type 2 Diabetes (T2D) (2018)	0.8	1.6	3.2	1.6	1.1	1.8	-0.3	-1.0
Lung FEV1/FVC ratio	0.3	1.5	3.3	1.8	1.1	-1.5	0.8	-0.5
Lung FVC	0.6	3.1	4.5	-0.3	-1.7	2.1	-1.9	2.1
Neuroticism	0.9	2.1	7.6	-0.0	-1.2	0.9	-0.7	2.8
Chronotype (morning person)	1.1	2.6	7.6	0.1	1.8	1.3	0.5	-2.8
Hair Pigment	0.1	1.8	3.1	1.3	-1.8	1.2	-0.1	1.6
Tanning	0.2	2.7	7.3	1.8	0.6	-0.2	-1.5	-2.7
Hand grip strength (left)	1.0	2.7	5.9	2.4	0.8	-0.7	-1.1	-2.3
Number of treatments/medications taken	0.7	1.2	2.9	0.1	1.0	1.5	1.7	-0.3
Average weekly spirits intake	0.3	0.4	1.3	0.6	-0.1	1.1	0.3	-0.5
Sensitivity / hurt feelings	3.0	5.1	13.5	-0.9	-2.1	-2.2	-1.5	3.7
Frequency of depressed mood in last 2 weeks	1.6	2.3	4.2	-1.3	1.7	2.1	0.3	-1.5
Hearing difficulty/problems: Yes	0.4	0.6	1.9	-1.4	0.8	-0.1	0.7	0.3
Relative age of first facial hair	0.4	0.9	1.7	-0.3	-0.4	-1.0	-1.3	1.2
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.2	-1.8	-0.5	-0.2	1.6	0.7
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.8	-0.6	0.2	-0.3	-0.9	0.2
Ever had hysterectomy (womb removed)	0.5	0.6	1.4	0.7	-0.7	-1.2	0.1	0.6
Systolic blood pressure, automated reading	0.7	2.2	8.9	-1.0	0.3	0.9	3.0	0.3
Eye problems/disorders: Diabetes related eye disease	1.3	1.5	3.1	-0.4	1.0	0.2	1.7	-1.8
Angina	2.3	3.1	6.6	0.8	1.7	0.3	2.6	-2.3
Medication for hormone replacement therapy	1.1	1.2	3.6	1.3	-0.9	0.2	-1.9	-0.3
Vitamin and mineral supplements	0.2	0.3	0.6	0.2	-0.5	-0.8	0.8	-0.1
Supplements: Zinc	0.8	0.9	3.0	-0.6	1.0	1.7	-0.1	-0.1
Medication: Co-codamol	0.3	0.3	0.9	0.4	0.2	0.1	0.9	0.8
Medication: Metformin	0.9	1.3	3.3	0.7	0.2	1.8	1.6	-0.3
Diabetes (father)	0.6	0.8	2.6	-0.6	-0.1	-0.2	-1.6	-0.8
Diabetes (mother)	1.5	1.9	4.0	-1.6	-2.0	0.5	-0.3	1.7
Severe depression (siblings)	0.9	1.0	2.7	0.4	0.3	-0.6	1.2	1.7
Pack years adult smoking proportion	0.7	1.0	2.8	0.0	-0.4	1.5	-1.7	0.0
Impedance of leg (right)	0.3	1.6	3.6	-1.9	-0.9	-1.0	-0.0	1.6
Leg fat-free mass (left)	0.4	2.3	6.4	1.0	1.2	1.4	-0.8	-2.5
Trunk fat percentage	0.3	1.1	3.7	0.0	-0.4	1.0	1.9	-0.8
Hand grip strength (right)	1.2	3.2	8.5	2.9	0.5	-1.8	-0.9	-1.8
Townsend deprivation index at recruitment	1.5	2.1	7.2	-0.1	1.0	2.7	-1.1	-0.9
Current tobacco smoking	2.1	3.5	8.3	1.9	1.7	2.9	-0.2	-1.6
Average weekly fortified wine intake	1.2	1.4	5.1	-2.3	-0.1	-0.2	1.1	0.7
Maternal smoking around birth	0.7	1.1	3.9	0.9	2.0	-0.5	0.1	-0.6
Fed-up feelings	0.8	1.4	4.4	0.9	-0.5	2.1	0.2	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	6.2	-0.7	1.3	2.5	0.2	-1.1
Relative age voice broke	0.2	0.3	0.7	-0.7	0.5	0.1	-0.8	0.1
Taking other prescription medications	0.7	1.1	2.8	-0.2	0.4	0.3	1.7	1.5
Age when periods started (menarche)	0.3	0.8	1.5	1.2	0.8	1.2	-0.1	0.6
Bilateral oophorectomy (both ovaries removed)	2.1	2.5	5.4	-1.1	-1.9	-2.3	-1.3	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.2	-1.5	0.2	-0.8	1.3	-0.6
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	2.8	0.1	-1.4	-0.2	-1.7	1.4
Qualifications: CSEs or equivalent	0.1	0.1	0.3	0.3	0.4	0.6	0.3	-0.3
Serious illness, injury or assault to yourself	1.4	1.7	3.2	-1.8	1.6	0.2	1.5	-0.9
High blood pressure	0.4	1.1	2.9	-0.2	0.0	1.7	1.4	0.9
Hayfever, allergic rhinitis or eczema	1.6	3.5	8.7	1.5	-2.3	-0.9	-0.8	3.0
Multivitamins +/- minerals	0.6	0.7	3.5	-0.1	0.0	0.2	-1.9	0.3
Stomach or abdominal pain in last month	0.6	0.7	1.7	-0.5	-0.8	-0.3	0.9	1.3
Supplements: Glucosamine	0.6	0.7	2.6	0.7	0.0	1.6	0.0	0.8
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.8	0.4	-0.9	0.1	-0.1	0.9
Medication: Atenolol	1.1	1.3	4.7	0.4	1.0	0.5	2.2	-0.7
Medication: Levothyroxine sodium	0.7	1.1	4.9	0.0	-0.4	-0.7	0.2	2.2
Sitting height	0.4	3.1	10.3	-0.3	-0.3	0.8	-3.2	-2.0
Chronic bronchitis/emphysema (father)	0.9	1.1	2.2	1.5	0.6	-0.1	-1.2	1.2
High blood pressure (mother)	3.3	4.7	8.9	2.9	-2.4	0.4	0.2	3.0
Body mass index (BMI)	0.8	3.4	5.2	1.6	1.5	1.6	2.2	-2.3
Impedance of leg (left)	0.4	2.1	4.0	-2.0	-1.5	-1.4	0.2	1.4
Leg predicted mass (left)	0.5	2.5	6.8	1.0	1.3	1.5	-0.9	-2.6
Trunk fat mass	0.4	1.7	2.6	0.7	0.4	1.6	1.6	-1.6
Waist circumference	0.3	1.1	3.3	0.5	-0.1	1.4	1.8	-0.5
Number of incorrect matches in round	0.5	0.9	3.0	0.5	1.1	1.7	0.1	-0.2
Past tobacco smoking	0.2	0.3	0.8	0.6	0.0	0.9	0.5	-0.4
Alcohol usually taken with meals	0.9	1.4	3.5	1.0	0.1	-1.9	-1.5	-0.5
Nervous feelings	0.8	1.4	2.8	-1.4	-1.2	-0.2	0.9	1.7
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.1	6.0	-2.4	1.4	0.8	1.4	0.4
Hearing difficulty/problems with background noise	0.6	1.0	1.7	-1.3	-0.5	-0.5	1.3	1.1
Hair/balding pattern: Pattern 2	0.1	0.2	0.3	0.3	-0.4	-0.0	0.6	0.5
Had menopause	0.0	0.0	0.1	-0.2	-0.2	-0.3	-0.1	0.1
Had other major operations	0.3	0.4	1.1	-0.4	1.1	0.3	-0.7	0.3
Forced vital capacity (FVC)	0.5	2.0	5.7	-0.1	-1.4	-1.5	-2.4	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.0	-1.0	-0.2	-0.7	0.9	-0.7
Ever unenthusiastic/disinterested for a whole week	2.5	3.0	9.4	3.1	0.4	1.8	1.2	0.9
Qualifications: None of the above	1.7	3.6	9.8	-1.6	1.6	3.1	-0.1	-1.7
Financial difficulties in last 2 years	1.1	1.5	5.6	1.1	0.3	2.4	-0.4	-0.6
Mouth/teeth dental problems	0.7	1.1	2.9	-1.7	0.5	0.4	-0.7	-1.4
Heart attack	1.6	2.1	4.2	1.5	0.2	-0.5	1.9	-2.0
Allergy	1.3	3.0	8.9	-0.3	2.3	0.9	0.5	-3.0
Pain all over the body in last month	0.8	0.9	2.2	1.2	0.3	-0.3	-0.6	1.5
Diabetes (self-reported)	0.9	1.4	4.4	0.5	1.3	2.1	0.6	-0.4
Hayfever/allergic rhinitis (self-reported)	1.7	2.2	7.5	2.7	-1.5	-0.7	-0.2	0.8
Medication: Ramipril	1.9	2.4	5.5	0.6	0.7	1.4	2.3	-2.0
Medication: Simvastatin	2.3	3.4	8.2	1.5	1.0	2.3	2.9	0.1
Fluid intelligence score	0.9	1.9	6.5	0.0	-1.8	-2.5	-0.3	0.0
Illnesses of siblings	1.1	1.6	3.7	-1.9	-0.9	-1.7	-0.7	0.4
Neuroticism score	0.8	1.8	3.5	-1.3	-1.2	1.4	-0.2	1.9
Weight	0.6	2.8	5.8	1.4	1.3	1.7	1.2	-2.4
Impedance of arm (right)	1.1	5.3	12.2	-2.5	-3.5	-1.1	-0.1	2.7
Arm fat percentage (right)	0.8	3.1	7.8	1.0	0.2	2.0	2.8	-1.7
Trunk fat-free mass	0.9	5.2	10.2	1.7	2.8	2.2	-0.7	-3.2
Hip circumference	0.3	1.4	2.8	1.3	0.6	0.9	1.2	-1.7
Time employed in main current job	0.6	0.7	1.7	-1.3	-0.3	1.2	0.1	0.3
Alcohol intake versus 10 years previously	1.5	2.2	6.0	2.5	0.6	0.5	-2.0	0.8
Father’s age at death	0.9	1.2	2.6	1.0	1.4	0.2	1.6	0.2
Worrier / anxious feelings	0.8	1.5	3.3	-0.0	0.5	1.4	1.8	1.4
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	3.4	0.3	1.8	1.8	-0.2	0.2
Falls in the last year	0.6	0.8	2.2	-0.4	1.5	0.2	-0.8	1.0
Hair/balding pattern: Pattern 3	0.7	1.0	2.2	1.3	0.6	1.5	-0.4	-0.8
Number of live births	0.4	0.5	1.0	0.9	1.0	-0.2	0.4	-0.9
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	4.8	0.4	-0.7	-2.2	-2.0	0.0
Pulse rate	1.0	1.7	4.0	-1.0	-0.7	1.1	2.0	1.4
Happiness	1.9	2.3	8.0	-0.1	1.7	2.8	-0.1	0.7
Noisy workplace	1.9	2.3	5.2	1.3	-0.8	2.3	-1.8	1.0
Qualifications: A levels/AS levels or equivalent	0.6	1.4	3.6	1.9	-0.4	-1.7	-0.5	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.3	-1.0	-0.5	-1.5	-0.6	0.2
Mouth/teeth dental problems: Dentures	0.5	0.8	3.1	1.8	0.9	0.3	-0.2	0.2
Asthma	0.1	0.3	0.9	-0.6	-0.4	-0.0	-1.0	-0.2
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	2.3	0.5	1.5	-1.0	-1.5	0.2
Medication: Cholesterol lowering	1.1	1.8	5.1	1.7	0.0	1.0	2.3	0.0
Depression (self-reported)	0.6	0.7	2.7	-0.8	0.1	1.6	0.3	-0.4
Medication: Lansoprazole	1.2	1.4	5.1	-0.4	-0.2	-0.3	2.3	1.2
Prospective memory result	1.0	1.3	4.5	-1.2	-0.5	2.1	-0.3	0.4
Lung cancer (father)	1.2	1.4	4.8	0.6	0.9	2.2	0.9	-0.5
Illnesses of mother	3.5	4.3	8.7	-1.0	2.6	-0.0	-2.3	-3.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	3.5	0.5	-0.7	-1.9	-1.4	0.7
Pulse wave Arterial Stiffness index	1.0	1.1	2.3	1.5	0.2	0.9	1.5	0.2
Impedance of arm (left)	1.4	6.7	13.8	-2.1	-3.7	-2.3	-0.3	3.1
Arm fat mass (right)	0.7	2.9	4.5	1.1	0.9	2.1	1.9	-2.1
Trunk predicted mass	0.9	5.3	10.3	1.7	2.9	2.2	-0.7	-3.2
Standing height	0.1	0.9	3.2	-0.3	-0.2	0.7	-1.8	-0.7
Length of working week for main job	1.0	1.1	3.0	1.1	-0.3	1.1	-1.7	-0.2
Exposure to tobacco smoke at home	0.5	0.6	1.7	0.9	1.3	0.3	-0.5	0.1
Breastfed as a baby	0.2	0.2	0.6	-0.3	0.8	0.0	-0.2	-0.4
Tense / ‘highly strung’	0.7	1.2	3.0	-0.9	0.1	1.7	0.7	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	3.2	0.3	1.8	1.1	-0.9	0.5
Hair/balding pattern: Pattern 4	4.1	9.9	32.2	0.8	5.7	-0.7	1.1	-3.9
Birth weight of first child	0.4	0.8	1.1	-0.9	0.9	1.0	-0.3	-1.1
Peak expiratory flow (PEF)	1.3	3.0	5.5	1.5	0.3	-2.2	-1.5	-2.3
Pulse wave reflection index	1.5	1.8	3.7	1.9	1.0	1.3	0.6	-1.4
Ever highly irritable/argumentative for 2 days	1.6	2.0	5.1	2.3	1.0	1.9	-0.2	0.4
Loud music exposure frequency	1.6	1.8	3.9	0.9	1.3	2.0	0.5	-1.6
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	5.6	2.4	-0.3	-1.7	0.8	0.7
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	4.3	-2.1	-0.5	-0.4	-1.3	-0.1
Blood clot in the leg (DVT)	0.6	0.8	2.8	-1.7	-0.8	0.2	0.8	0.2
Medication: Paracetamol	0.2	0.3	0.4	0.4	-0.3	0.6	-0.5	0.6
Headache pain in last month	0.4	0.7	2.4	-0.5	-0.3	-1.5	0.8	-0.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.0	-0.8	0.1	-0.8	-1.0	-0.9
Glaucoma (self-reported)	1.5	1.7	3.5	1.9	-1.4	-1.2	0.9	0.9
Gout (self-reported)	0.9	1.2	5.4	-0.6	-0.5	-2.3	0.3	0.4
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	7.8	-1.0	-0.6	-0.4	0.0	2.8
Medication: Amlodipine	1.1	1.6	3.4	-1.2	0.6	1.2	1.8	1.2
Medication: Ventolin 100micrograms inhaler	1.1	1.4	3.1	0.7	0.5	-1.2	-1.8	-1.3
Birth weight	1.0	2.1	3.7	-1.3	1.2	0.8	-1.9	-1.8
Chronic bronchitis/emphysema (mother)	0.8	1.0	2.1	0.6	1.5	0.0	1.2	-1.0
High blood pressure (siblings)	1.6	2.3	8.0	2.8	0.3	1.0	-1.5	-0.0
Forced vital capacity (FVC), Best measure	0.5	1.9	3.1	0.3	-1.6	-1.4	-1.8	1.3
Body fat percentage	0.5	2.0	5.6	0.4	-0.0	1.4	2.4	-1.5
Leg fat percentage (right)	1.1	3.8	6.3	0.9	1.8	1.6	2.5	-2.5
Arm fat-free mass (right)	0.9	4.8	10.0	1.7	2.8	1.6	-0.6	-3.2
Exposure to tobacco smoke outside home	1.2	1.6	3.7	-1.9	-0.7	0.1	-1.5	1.3
Comparative body size at age 10	0.2	0.6	1.8	1.3	0.0	0.6	0.2	-1.0
Number of full brothers	0.5	0.6	1.0	-0.3	1.0	0.9	0.7	-0.6
Worry too long after embarrassment	0.8	1.4	3.2	0.6	-1.8	0.5	-0.3	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	3.4	-0.7	1.3	1.8	-1.0	-0.3
Wheeze or whistling in the chest in last year	0.4	0.7	3.0	-0.4	0.0	-0.2	-1.7	0.6
Number of children fathered	1.1	1.2	2.9	-0.4	-1.3	-0.9	1.7	0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	3.2	-0.5	-0.7	-1.3	-1.8	0.4
Age at first live birth	0.2	0.4	0.9	0.1	-0.8	-0.6	1.0	0.3
Pulse wave peak to peak time	0.9	1.1	2.4	-1.6	-0.2	-0.8	-1.5	-0.3
Health satisfaction	1.9	2.5	6.7	-0.3	2.6	2.2	0.6	-0.8
Shortness of breath walking on level ground	0.6	0.7	1.3	0.3	0.8	1.1	1.1	0.2
Qualifications: College or University degree	1.3	4.0	10.3	-0.4	-3.2	-2.5	-0.8	1.6
Eye problems/disorders: None of the above	1.9	2.1	5.8	0.1	0.6	2.1	-2.4	-0.3
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.8	1.0	0.0	0.5	1.3	0.1
Emphysema/chronic bronchitis	1.3	1.4	4.1	-0.2	2.0	-0.7	0.7	-1.4
Medication for pain relief, constipation, heartburn	0.4	0.7	1.9	0.1	-1.4	-0.4	-1.0	-0.8
Neck or shoulder pain in last month	0.7	1.0	2.6	-0.0	0.9	-0.2	1.2	-1.6
Medication: Blood pressure	0.2	0.3	0.7	0.2	0.1	0.8	0.7	0.4
Angina (self-reported)	2.6	3.5	7.7	1.0	1.6	0.5	2.8	-2.5
Migraine (self-reported)	1.4	1.7	6.0	2.4	0.8	-0.5	-0.8	1.0
Medication: Ibuprofen	1.0	1.1	2.2	0.7	1.4	-1.5	-1.0	-0.2
Medication: Allopurinol	0.3	0.4	1.1	-0.5	-0.5	-0.7	0.0	1.1
Medication: Omeprazole	1.8	2.2	3.6	-1.3	1.9	1.6	1.7	0.6
Medication: Seretide 50 evohaler	0.3	0.4	1.2	-0.4	0.4	0.2	1.1	-0.6
Mean time to correctly identify matches	0.5	0.9	3.7	-0.7	0.6	1.9	-0.0	0.1
Heart disease (mother)	0.4	0.5	2.0	0.1	-0.6	-0.5	0.2	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.8	3.3	8.2	2.0	1.1	1.6	-0.7	-2.9
Whole body fat mass	0.5	2.3	4.0	0.8	0.5	1.7	1.9	-2.0
Leg fat mass (right)	1.0	4.0	7.9	1.0	1.8	2.0	2.0	-2.8
Arm predicted mass (right)	0.8	4.1	8.9	1.7	2.6	1.4	-0.5	-3.0
Pulse rate, automated reading	3.2	10.3	17.6	-4.0	-4.2	-1.9	1.1	3.6
Alcohol intake frequency.	1.3	3.1	8.6	2.3	2.9	0.7	0.8	-0.9
Comparative height size at age 10	0.2	1.1	3.5	1.9	0.1	1.3	0.3	-0.4
Number of full sisters	1.4	1.7	2.7	-0.6	1.6	1.6	-1.1	-1.3
Suffer from ‘nerves’	0.4	0.7	1.8	-1.4	-0.3	0.2	0.8	-0.8
Overall health rating	1.1	2.4	5.1	-1.4	1.2	1.9	2.3	0.0
Chest pain or discomfort	1.3	1.9	3.2	-0.6	1.0	1.8	1.5	-1.5
Had major operations	1.4	1.6	7.0	0.3	0.9	0.3	2.6	0.5
Age at last live birth	0.7	1.0	2.9	0.7	-0.1	0.1	1.7	-1.3
Family relationship satisfaction	2.6	3.2	9.2	0.5	2.4	3.0	-0.3	-0.9
Leg pain on walking	1.1	1.4	3.5	-0.5	0.7	1.9	0.6	1.5
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.4	0.3	-0.4	1.0	1.0	1.2
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.2	0.4	-1.5	-0.9	-0.8	0.9
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.6	0.8	-0.8	0.2	-0.1	-0.4
Medication: Aspirin	0.2	0.3	0.9	-0.4	-0.1	-0.2	0.9	-0.5
Supplements: Vitamin C	0.3	0.3	0.8	0.1	0.2	0.8	-0.4	0.9
Knee pain experienced in last month	0.5	0.8	1.7	-0.7	-0.9	-1.3	0.2	0.9
Hypertension (Self-reported)	0.5	1.3	3.9	-0.6	0.3	2.0	1.4	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.9	4.6	10.9	-1.9	0.1	0.5	3.3	2.9
Illnesses of father: Heart disease	1.1	1.5	4.3	2.1	-1.0	-1.3	-0.4	0.4
Illnesses of siblings: Diabetes	0.8	0.9	3.4	0.5	-0.7	0.3	0.6	1.8
Smoking status: Previous	0.8	1.2	2.9	-1.4	-0.3	-1.7	-0.2	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.7	2.2	0.9	-0.6	0.4	-0.4	-1.5
Whole body fat-free mass	0.7	4.1	9.1	1.5	2.2	1.8	-0.8	-3.0
Leg fat-free mass (right)	0.4	2.0	6.2	0.9	1.0	1.2	-0.7	-2.5
Arm fat percentage (left)	0.7	2.7	7.9	1.2	0.1	1.4	2.8	-1.5
Average weekly red wine intake	0.2	0.4	0.7	0.1	-0.7	-0.8	-0.7	0.4
Handedness (chirality/laterality): Left-handed	1.2	1.4	4.0	-0.5	2.0	1.3	-1.0	-0.5
Mood swings	0.3	0.5	1.2	-1.1	0.6	0.7	-0.8	0.4
Loneliness, isolation	1.6	2.2	8.5	-1.0	-0.5	2.9	-0.1	1.0
Long-standing illness, disability or infirmity	0.8	1.2	2.4	1.6	0.3	1.3	1.1	0.8
Ever had bowel cancer screening	0.6	0.7	3.4	-0.1	0.1	-0.3	-0.2	1.8
Diabetes diagnosed by doctor	0.7	1.1	2.7	-0.2	1.4	1.6	0.9	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.7	0.5	1.7	0.5	0.5	0.5
Friendships satisfaction	0.6	0.8	2.2	1.2	-0.0	0.3	0.1	1.5
Qualifications: nursing, teaching	0.9	1.3	6.3	-0.0	0.1	-2.5	-0.4	0.4
Commuting to job workplace: Walk	1.9	2.0	3.5	-0.3	1.9	1.8	1.1	-1.5
Eye problems/disorders: Cataract	1.0	1.2	2.6	0.6	0.0	-1.6	1.5	0.7
Mouth/teeth dental problems: Mouth ulcers	1.2	2.0	4.8	-0.3	-2.0	-0.9	-0.3	2.2
Medication for cholesterol	0.4	0.6	2.0	-0.1	0.4	-1.4	-0.5	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.4	1.2	1.1	-0.9	0.6	-0.3
Back pain experienced in last month	0.2	0.3	0.6	-0.5	-0.8	0.7	0.4	-0.2
Mineral and other dietary supplements	0.1	0.2	0.6	0.2	-0.8	-0.0	-0.2	-0.5
Breast cancer (self-reported)	0.2	0.2	0.8	-0.2	-0.5	-0.2	-0.4	0.9
Asthma (self-reported)	0.3	0.6	1.6	-1.3	-0.6	-0.2	-0.9	-0.2
Osteoporosis (self-reported)	0.3	0.4	0.8	-0.3	-0.3	0.6	0.7	-0.9
Osteoarthritis (self-reported)	1.1	1.5	3.9	0.6	1.5	0.9	2.0	0.3
Medication: Aspirin	0.3	0.5	1.5	-0.5	-0.2	-0.4	1.2	-0.6
Medication: Gliclazide	1.2	1.3	4.0	0.7	0.7	1.2	2.0	0.3
Illnesses of father: None of the above (group 1)	0.2	0.3	0.6	-0.6	-0.5	0.1	-0.7	0.4
Smoking status: Current	2.2	3.5	6.6	2.0	1.8	2.6	-0.5	-1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.9	-1.0	-0.5	-0.8	-0.2	0.4
Whole body water mass	0.7	4.1	8.8	1.5	2.3	1.9	-0.7	-3.0
Leg predicted mass (right)	0.4	2.0	6.3	0.9	1.0	1.2	-0.8	-2.5
Arm fat mass (left)	0.7	2.7	4.5	1.4	0.8	1.5	2.1	-2.1
Number of self-reported non-cancer illnesses	0.4	0.6	1.2	0.3	-0.7	0.8	1.1	0.9
Average weekly champagne plus white wine intake	0.5	0.7	1.8	-0.4	-0.9	-1.3	0.6	0.6
Miserableness	0.5	0.9	2.3	-0.7	0.1	1.3	1.5	0.5
Guilty feelings	0.9	1.3	4.2	-1.0	-0.5	1.0	-2.0	0.4
Wears glasses or contact lenses	1.4	1.6	5.1	0.8	-1.1	-0.2	1.0	2.3
Ever taken oral contraceptive pill	2.5	2.8	4.1	0.9	-2.0	-1.6	-1.6	1.9
Hearing aid user	0.6	0.7	2.3	-0.3	1.5	1.0	-0.1	0.5
Mother’s age at death	0.6	0.7	2.0	0.0	-0.2	1.4	1.0	0.9
Financial situation satisfaction	2.4	2.9	9.4	1.9	-0.0	3.1	-1.1	-0.6
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	-0.3	-0.5	0.0	-0.2	-0.6
Commuting to job workplace: Public transport	0.6	0.7	2.0	-0.4	1.4	0.1	-0.0	-1.2
Eye problems/disorders: Glaucoma	1.4	1.7	2.7	0.7	-1.3	-1.2	1.7	1.4
Medication: Blood pressure	0.4	0.7	1.9	-1.4	-0.3	0.8	1.0	0.2
Pain type(s) experienced in last month: Hip pain	1.5	1.8	5.5	-0.9	1.1	2.3	0.8	-0.9
Supplements: Fish oil (including cod liver oil)	0.0	0.1	0.2	0.3	0.4	-0.1	-0.0	0.1
High cholesterol (Self-reported)	0.7	1.3	3.6	1.1	-0.8	0.8	1.9	-0.2
Medication: Bendroflumethiazide	0.7	1.1	4.2	-0.2	-0.1	2.0	-0.2	1.0
Medication: Paracetamol	0.2	0.2	0.5	0.2	-0.5	0.1	-0.7	0.7
Medication: Lisinopril	0.6	0.7	1.2	-1.1	-1.0	-1.0	0.5	0.4
Medication: Atorvastatin	0.9	1.1	1.7	1.1	-1.2	-0.6	1.3	-0.9
Illnesses of father: High blood pressure	1.1	1.3	2.1	-1.3	-1.4	-1.0	-0.4	1.2
Alcohol drinker status: Never	1.2	1.5	5.0	-0.3	2.2	0.5	1.3	-0.7
Ever smoked	0.1	0.1	0.4	-0.1	0.2	-0.1	-0.6	-0.0
Basal metabolic rate	0.7	3.6	8.9	1.3	1.9	1.9	-0.4	-3.0
Leg fat percentage (left)	1.1	3.8	7.2	1.0	1.5	1.4	2.6	-2.7
Arm fat-free mass (left)	1.0	5.2	10.7	1.6	2.9	2.0	-0.5	-3.3
Number of operations (self-reported)	0.3	0.4	1.2	0.5	-0.0	-0.7	0.3	1.1
Average weekly beer plus cider intake	0.3	0.5	1.8	-1.3	0.1	0.6	0.4	0.4
Irritability	0.2	0.4	0.8	-0.9	0.6	-0.2	0.5	-0.7
Risk taking	0.9	1.3	4.2	-1.3	0.5	0.6	-2.0	0.2
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.8	-0.1	-0.1	-0.7	0.7	0.9
Fractured/broken bones in last 5 years	1.4	1.8	5.8	-0.6	0.4	1.0	-2.4	1.3
Age started oral contraceptive pill	0.6	0.7	1.2	1.1	-1.0	-0.8	0.8	0.5
Diastolic blood pressure, automated reading	0.5	1.7	5.9	-0.3	-0.3	1.5	2.4	0.2
Ever depressed for a whole week	1.0	1.2	3.9	2.0	0.1	1.3	-0.3	0.6
Unable to work because of sickness or disability	1.3	1.7	4.9	-0.1	2.2	0.6	0.8	-1.5
Commuting to job workplace: Cycle	0.7	0.9	1.8	0.9	1.0	-0.7	0.3	-1.3
Myopia	0.3	0.5	1.4	0.3	-0.2	-0.3	-1.2	0.9
Vascular/heart problems diagnosed by doctor	0.8	2.2	6.5	0.5	-1.0	-1.9	-2.5	0.1
Cholesterol lowering medication	2.0	3.0	10.5	0.5	1.0	1.6	3.2	-0.8
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	2.3	-0.9	1.5	1.3	1.5	1.2
Pain experienced in last month	0.3	0.4	1.4	1.2	-0.1	-0.1	-0.9	-0.0
Supplements: Calcium	0.7	0.7	1.7	-1.3	1.1	0.1	0.3	-0.8
Basal cell carcinoma (self-reported)	0.8	1.0	3.1	0.3	-0.4	-1.8	1.0	0.7
Heart attack/myocardial infarction (self-reported)	1.6	2.1	4.5	1.4	0.2	-0.4	1.9	-2.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.8	-1.7	-0.7	0.1	0.6	0.5
Heart disease (siblings)	1.6	1.9	3.5	-1.0	1.1	0.9	1.9	-1.8
Alcohol drinker status: Previous	0.9	1.1	2.2	-0.8	1.5	-0.4	1.5	0.4
Pack years of smoking	0.7	1.1	3.0	0.1	-0.3	1.7	-1.5	0.2
Impedance of whole body	0.9	4.8	9.5	-2.1	-3.1	-2.0	-0.5	2.4
Leg fat mass (left)	1.0	3.9	8.2	1.2	1.5	1.8	2.1	-2.9
Arm predicted mass (left)	0.9	4.5	9.0	1.8	2.6	2.0	-0.4	-3.0