Hub : Traits :

Verbal and Numeric Reasoning (VNR)

821 significantly associated models · 186 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 31402148 32762733 1 1 1.1e-12 6.5e-12 1.0e+00 100 PEF1
2 1 40799427 42542658 2 1 1.2e-14 1.6e-14 6.6e-07 58 FOXO6
3 1 43476957 45088053 1 1 1.3e-07 7.9e-08 1.0e+00 100 ST3GAL3
4 1 71163715 73435171 1 1 6.3e-18 1.2e-12 9.6e-01 100 NEGR1
5 1 109135869 110742615 5 1 3.0e-08 2.4e-08 2.0e-01 95 SORT1
6 1 171053153 172474017 1 1 1.6e-07 1.2e-07 2.4e-01 95 METTL13
7 2 23453834 24924438 1 1 1.1e-07 3.4e-07 1.0e-01 90 UBXN2A
8 2 72774203 74604895 5 5 4.6e-11 8.3e-10 NaN NaN ALMS1 ALMS1P FBXO41 PRADC1
9 2 99468341 101731705 3 3 8.3e-10 3.4e-11 1.0e-01 94 AFF3 CHST10
10 2 117979194 119470084 1 1 3.0e-08 7.4e-06 1.2e-02 68 CCDC93
11 2 161297929 162790882 1 1 8.5e-09 3.2e-08 1.0e+00 100 TANK
12 2 200086752 201490349 1 1 2.2e-07 4.4e-06 5.1e-01 98 C2orf69
13 3 23234618 24686628 1 1 1.1e-09 2.5e-15 2.2e-07 57 NKIRAS1
14 3 48618666 51043528 23 1 3.4e-19 1.5e-18 3.0e-01 99 RNF123
15 3 51616334 53985919 15 1 2.2e-10 2.3e-10 1.0e+00 100 NT5DC2
16 4 17104059 18507692 1 1 4.7e-10 3.0e-09 1.9e-01 95 DCAF16
17 4 87655053 89073197 1 1 2.2e-07 1.9e-06 7.9e-01 100 NUDT9
18 4 105598022 107092169 1 1 1.9e-11 7.1e-15 7.1e-05 74 PPA2
19 4 151637154 153373680 3 1 4.6e-09 2.3e-09 1.0e+00 100 PET112
20 5 138860604 140745333 9 2 3.3e-11 1.1e-10 2.7e-01 97 PFDN1 WDR55
21 5 176132977 177591495 2 1 5.7e-08 5.2e-09 1.0e+00 100 DBN1
22 6 10842333 12277622 1 1 3.1e-08 1.3e-07 1.0e+00 100 TMEM170B
23 6 24382897 26689223 3 3 4.4e-08 6.4e-15 8.4e-06 67 CMAH CMAHP U91328.21
24 6 108183628 109704062 1 1 2.5e-10 2.7e-15 2.0e-06 64 FOXO3
25 7 70546596 72313144 1 1 1.7e-07 3.1e-09 3.7e-03 76 CALN1
26 7 126529931 128425768 3 13 3.0e-10 1.8e-12 9.9e-71 -536 GCC1 LRRC4 SND1
27 8 70799045 72220529 1 1 2.4e-08 4.2e-10 3.8e-07 34 TRAM1
28 8 86841229 88211679 1 1 1.7e-07 1.0e-07 7.4e-02 89 RMDN1
29 8 144838590 146293414 4 1 2.4e-08 6.1e-07 1.6e-01 92 HSF1
30 9 34382175 35792423 2 1 5.2e-08 8.5e-08 1.0e+00 100 PIGO
31 9 95518076 96910958 1 1 1.8e-07 6.2e-08 1.9e-02 81 FAM120AOS
32 10 64531160 65911294 1 1 3.5e-07 5.1e-07 3.8e-04 50 JMJD1C-AS1
33 10 102853189 104242886 1 1 1.6e-10 1.8e-12 2.7e-05 65 NPM3
34 11 46622392 48559571 7 1 5.9e-09 3.5e-08 6.5e-01 99 C1QTNF4
35 11 94825532 96261289 1 1 1.5e-07 3.9e-06 3.4e-01 96 CEP57
36 12 48698518 50237637 4 1 2.6e-09 3.4e-11 3.5e-03 80 PRKAG1
37 12 55694116 57125879 3 1 1.8e-07 1.7e-07 1.0e+00 100 RPS26
38 12 57435122 58897077 2 1 3.7e-07 2.4e-08 1.9e-02 82 RP11-571M6.17
39 12 122713991 124162750 2 1 1.2e-08 7.6e-07 6.0e-01 99 ARL6IP4
40 14 103289637 104859419 2 1 1.5e-07 5.4e-08 1.2e-02 79 RP11-73M18.8
41 15 39955786 41353079 1 1 1.0e-07 1.9e-08 1.0e+00 100 DISP2
42 16 11447272 13364255 1 1 7.3e-09 3.9e-07 1.6e-03 61 SNX29
43 16 27655848 29595483 25 1 2.0e-14 3.9e-14 9.6e-02 95 SULT1A2
44 16 52772129 54235440 2 1 6.8e-13 2.8e-12 2.8e-01 98 AKTIP
45 16 71206836 72569466 1 1 3.6e-07 1.5e-06 4.3e-03 65 ATXN1L
46 17 17292491 18325085 1 1 1.4e-07 8.2e-08 6.1e-03 74 DRG2
47 17 34146026 35675511 5 1 3.0e-10 2.4e-09 1.5e-01 94 GGNBP2
48 17 43315547 43913030 1 1 2.0e-08 1.7e-06 1.1e-04 35 MAPT
49 19 17138985 19174237 2 2 2.3e-07 9.7e-08 1.0e+00 100 MAP1S PGPEP1
50 20 46840115 48591758 5 1 2.8e-17 7.5e-14 8.5e-01 100 CSE1L
51 21 18271223 19680363 1 1 2.1e-07 4.5e-08 1.0e+00 100 BTG3
52 21 39856991 41390857 1 1 2.0e-07 3.9e-05 9.0e-01 100 BRWD1
53 22 39101079 40571499 2 1 1.9e-11 2.1e-09 6.4e-04 68 MGAT3
54 22 41498627 43229137 9 1 1.8e-08 2.2e-08 3.3e-04 59 CYP2D6

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 1.43 2 2 6.1 0.00 1.0e+00 RNF123 SULT1A2
Irritable Bowel Disease (IBD) 1.50 2 2 6.1 0.00 1.0e+00 RNF123 SULT1A2
Ulcerative Colitis (UC) 1.38 2 1 3.0 0.00 1.0e+00 RNF123 SULT1A2
Major Depression (MDD) 2.29 2 1 3.0 0.00 1.0e+00 FAM120AOS NEGR1
Reaction Time 2.43 5 4 12.1 0.19 7.6e-01 C2orf69 CSE1L FOXO3 PFDN1 PRKAG1
Breast Cancer 1.16 2 0 0.0 0.00 1.0e+00 MAPT RNF123
Ovarian Cancer 1.43 1 1 3.0 0.00 1.0e+00 MAPT
Prostate Cancer 1.68 1 0 0.0 0.00 1.0e+00 RNF123
Age at First Birth 2.33 2 1 3.0 0.00 1.0e+00 CHST10 RNF123
Bipolar Disorder 2.16 1 1 3.0 0.00 1.0e+00 PRKAG1
Body Mass Index (BMI) (2010) 2.73 4 3 9.1 -0.35 6.5e-01 C1QTNF4 CYP2D6 NEGR1 SULT1A2
Coronary Artery Disease (CAD) 1.91 1 0 0.0 0.00 1.0e+00 DRG2
Crohns Disease (2012) 1.69 2 2 6.1 0.00 1.0e+00 RNF123 SULT1A2
HDL Cholesterol 1.54 1 1 3.0 0.00 1.0e+00 C1QTNF4
LDL Cholesterol 1.47 1 1 3.0 0.00 1.0e+00 SORT1
Neuroticism 1.45 2 0 0.0 0.00 1.0e+00 MAPT TANK
Schizophrenia 2.64 7 3 9.1 -0.37 4.2e-01 ALMS1 ALMS1P ARL6IP4 C2orf69 MGAT3 NT5DC2 RP11-73M18.8
Ulcerative Colitis 1.47 1 1 3.0 0.00 1.0e+00 RNF123
Blood Eosinophil Count 0.86 3 3 9.1 0.00 1.0e+00 MAPT PIGO RPS26
Blood Platelet Count 1.08 15 8 24.2 0.09 7.2e-01 ATXN1L C1QTNF4 DCAF16 FAM120AOS HSF1 JMJD1C-AS1 LRRC4 MAP1S METTL13 NT5DC2 NUDT9 PET112 PIGO SND1 TMEM170B
Blood Red Count 1.41 16 6 18.2 -0.22 4.2e-01 AFF3 C2orf69 CHST10 CSE1L DRG2 HSF1 MAPT METTL13 NT5DC2 NUDT9 PIGO RNF123 RP11-73M18.8 RPS26 SORT1 SULT1A2
Blood White Count 1.27 13 8 24.2 -0.63 2.0e-02 C1QTNF4 DCAF16 DRG2 FOXO6 JMJD1C-AS1 MAP1S MGAT3 PET112 PGPEP1 PIGO RNF123 RP11-73M18.8 UBXN2A
Heel T-Score 1.00 8 6 18.2 -0.14 7.4e-01 ARL6IP4 DCAF16 FAM120AOS MAPT NEGR1 PRKAG1 RNF123 RPS26
BMI 3.05 16 13 39.4 -0.12 6.3e-01 C1QTNF4 C2orf69 CHST10 FOXO3 GGNBP2 NEGR1 NT5DC2 PEF1 PFDN1 PRKAG1 RMDN1 RNF123 RPS26 SORT1 SULT1A2 WDR55
Height 2.55 26 19 57.6 0.58 1.8e-03 AFF3 AKTIP ARL6IP4 ATXN1L C1QTNF4 CSE1L DCAF16 DISP2 DRG2 FOXO3 JMJD1C-AS1 MAPT METTL13 MGAT3 NKIRAS1 NT5DC2 PEF1 PET112 PPA2 PRADC1 RMDN1 RP11-571M6.17 RP11-73M18.8 SULT1A2 UBXN2A WDR55
Waist Hip Ratio (WHR) 1.64 7 5 15.2 -0.95 1.2e-03 AFF3 AKTIP DISP2 DRG2 MAPT MGAT3 NT5DC2
Systolic Blood Pressure 2.28 11 8 24.2 -0.72 7.9e-04 ATXN1L C2orf69 DCAF16 FBXO41 FOXO3 LRRC4 MAPT PRADC1 RNF123 SND1 WDR55
Smoking Status 1.84 2 2 6.1 0.00 1.0e+00 RPS26 TANK
Allergy or Eczema 1.62 4 2 6.1 0.87 1.3e-01 GGNBP2 NEGR1 RPS26 SULT1A2
Cardiovascular Disease 1.94 7 3 9.1 -0.15 7.2e-01 ATXN1L CEP57 DCAF16 FBXO41 HSF1 NEGR1 PRADC1
Hypothyroidism (self reported) 1.48 3 2 6.1 0.00 1.0e+00 C1QTNF4 RPS26 TANK
Respiratory disease 1.75 2 1 3.0 0.00 1.0e+00 RPS26 WDR55
Type 2 Diabetes (T2D) 1.43 2 0 0.0 0.00 1.0e+00 AKTIP HSF1
Lung FEV1/FVC ratio 1.62 12 6 18.2 -0.03 9.4e-01 BTG3 DRG2 FAM120AOS FOXO3 JMJD1C-AS1 MAP1S MAPT NEGR1 NKIRAS1 PEF1 PPA2 RPS26
Lung FVC 1.88 13 7 21.2 0.21 4.9e-01 ARL6IP4 BTG3 DCAF16 DISP2 DRG2 FOXO3 FOXO6 HSF1 JMJD1C-AS1 MAPT RNF123 RPS26 UBXN2A
Neuroticism 2.43 9 1 3.0 -0.78 1.4e-02 BTG3 C1QTNF4 FAM120AOS LRRC4 MAPT METTL13 NT5DC2 RNF123 SND1
Chronotype (morning person) 1.97 6 1 3.0 0.37 4.7e-01 C1QTNF4 CALN1 CYP2D6 DBN1 GCC1 LRRC4
Hair Pigment 0.16 5 2 6.1 -0.76 1.3e-01 C1QTNF4 FOXO3 JMJD1C-AS1 PRKAG1 RPS26
Tanning 0.19 2 0 0.0 0.00 1.0e+00 ATXN1L NT5DC2
Hand grip strength (left) 2.62 8 4 12.1 0.19 6.3e-01 C1QTNF4 CALN1 CYP2D6 DCAF16 MAPT NPM3 PEF1 SND1
Number of treatments/medications taken 2.68 6 1 3.0 0.67 1.5e-01 DCAF16 FBXO41 NEGR1 PRADC1 RNF123 TANK
Average weekly spirits intake 2.35 1 0 0.0 0.00 1.0e+00 SND1
Sensitivity / hurt feelings 2.07 1 1 3.0 0.00 1.0e+00 MAPT
Frequency of depressed mood in last 2 weeks 2.21 3 2 6.1 0.00 1.0e+00 CSE1L FAM120AOS JMJD1C-AS1
Hearing difficulty/problems: Yes 1.10 1 0 0.0 0.00 1.0e+00 FAM120AOS
Relative age of first facial hair 1.42 2 1 3.0 0.00 1.0e+00 FOXO3 MAPT
Systolic blood pressure, automated reading 2.10 7 2 6.1 0.75 3.0e-02 DCAF16 FBXO41 MAPT PPA2 PRADC1 RNF123 SND1
Medication: Co-codamol 1.48 1 0 0.0 0.00 1.0e+00 RNF123
Medication: Metformin 1.38 1 0 0.0 0.00 1.0e+00 C1QTNF4
Pack years adult smoking proportion 1.76 1 1 3.0 0.00 1.0e+00 JMJD1C-AS1
Impedance of leg (right) 2.26 15 10 30.3 0.01 9.6e-01 AKTIP C1QTNF4 C2orf69 CEP57 DRG2 GCC1 MAPT NEGR1 NT5DC2 PRKAG1 RNF123 RPS26 SND1 SORT1 SULT1A2
Leg fat-free mass (left) 2.55 16 11 33.3 -0.33 2.1e-01 AKTIP ATXN1L C2orf69 DCAF16 FOXO3 GGNBP2 MGAT3 NEGR1 PEF1 PPA2 RNF123 RPS26 SORT1 SULT1A2 UBXN2A WDR55
Trunk fat percentage 2.35 11 5 15.2 0.56 5.7e-02 C1QTNF4 CEP57 CHST10 CMAHP FOXO3 GGNBP2 MAPT NEGR1 RMDN1 RNF123 SULT1A2
Hand grip strength (right) 2.25 5 2 6.1 -0.22 7.2e-01 C1QTNF4 DCAF16 MAPT NPM3 PEF1
Maternal smoking around birth 1.79 1 1 3.0 0.00 1.0e+00 GGNBP2
Fed-up feelings 2.53 2 1 3.0 0.00 1.0e+00 MAPT RNF123
Frequency of unenthusiasm / disinterest in last 2 weeks 2.13 1 1 3.0 0.00 1.0e+00 JMJD1C-AS1
Relative age voice broke 1.56 2 1 3.0 0.00 1.0e+00 FOXO3 MAPT
Taking other prescription medications 1.92 1 1 3.0 0.00 1.0e+00 RNF123
Age when periods started (menarche) 1.99 5 3 9.1 0.32 6.0e-01 C1QTNF4 FOXO3 NEGR1 NT5DC2 RNF123
Heel bone mineral density (BMD) T-score, automated (left) 0.86 1 0 0.0 0.00 1.0e+00 RNF123
Qualifications: CSEs or equivalent 2.51 4 0 0.0 0.81 1.9e-01 FOXO6 JMJD1C-AS1 RNF123 ST3GAL3
High blood pressure 1.73 4 1 3.0 0.36 6.4e-01 CEP57 DCAF16 FBXO41 NEGR1
Hayfever, allergic rhinitis or eczema 1.36 3 1 3.0 0.00 1.0e+00 NEGR1 RPS26 SULT1A2
Medication: Levothyroxine sodium 1.44 1 1 3.0 0.00 1.0e+00 RPS26
Sitting height 2.68 13 12 36.4 -0.89 3.7e-05 AKTIP ARL6IP4 C1QTNF4 CSE1L DCAF16 FOXO3 MAPT MGAT3 PEF1 PPA2 RP11-571M6.17 UBXN2A WDR55
Body mass index (BMI) 2.96 10 7 21.2 0.52 1.0e-01 C1QTNF4 C2orf69 CHST10 FOXO3 GGNBP2 NEGR1 RMDN1 RNF123 RPS26 SULT1A2
Impedance of leg (left) 2.16 14 8 24.2 0.07 7.9e-01 AKTIP C2orf69 DRG2 GCC1 MAPT NEGR1 NT5DC2 PPA2 PRKAG1 RNF123 RPS26 SND1 SORT1 SULT1A2
Leg predicted mass (left) 2.54 16 11 33.3 -0.33 2.1e-01 AKTIP ATXN1L C2orf69 DCAF16 FOXO3 GGNBP2 MGAT3 NEGR1 PEF1 PPA2 RNF123 RPS26 SORT1 SULT1A2 UBXN2A WDR55
Trunk fat mass 2.33 8 6 18.2 0.56 1.1e-01 C1QTNF4 CHST10 CMAHP FOXO3 GGNBP2 NEGR1 RNF123 SULT1A2
Waist circumference 2.43 9 6 18.2 0.59 7.2e-02 C1QTNF4 CHST10 FOXO3 GGNBP2 NEGR1 RMDN1 RNF123 RPS26 SULT1A2
Number of incorrect matches in round 2.24 2 1 3.0 0.00 1.0e+00 NPM3 TMEM170B
Past tobacco smoking 1.52 2 0 0.0 0.00 1.0e+00 RPS26 TANK
Alcohol usually taken with meals 2.18 2 0 0.0 0.00 1.0e+00 CHST10 NEGR1
Nervous feelings 1.57 2 1 3.0 0.00 1.0e+00 MAPT NT5DC2
Frequency of tenseness / restlessness in last 2 weeks 1.76 2 0 0.0 0.00 1.0e+00 JMJD1C-AS1 MAPT
Had other major operations 1.34 1 0 0.0 0.00 1.0e+00 PPA2
Forced vital capacity (FVC) 2.73 11 7 21.2 -0.75 8.5e-03 C1QTNF4 CSE1L DCAF16 FOXO6 MAPT PET112 PPA2 RNF123 U91328.21 UBXN2A WDR55
Heel bone mineral density (BMD) T-score, automated (right) 0.83 1 0 0.0 0.00 1.0e+00 DCAF16
Ever unenthusiastic/disinterested for a whole week 1.83 1 0 0.0 0.00 1.0e+00 WDR55
Qualifications: None of the above 5.89 23 12 36.4 0.98 1.9e-16 AFF3 AKTIP ALMS1P ATXN1L CALN1 CEP57 CHST10 CSE1L DBN1 FAM120AOS FOXO3 GGNBP2 JMJD1C-AS1 NEGR1 NPM3 PET112 PPA2 RNF123 RPS26 SORT1 ST3GAL3 SULT1A2 TANK
Financial difficulties in last 2 years 1.84 1 0 0.0 0.00 1.0e+00 CSE1L
Allergy 1.42 2 1 3.0 0.00 1.0e+00 NEGR1 RPS26
Diabetes (self-reported) 1.09 1 0 0.0 0.00 1.0e+00 AKTIP
Hayfever/allergic rhinitis (self-reported) 1.29 1 1 3.0 0.00 1.0e+00 RPS26
Fluid intelligence score 10.11 45 25 75.8 -0.99 2.6e-42 AFF3 AKTIP ALMS1 ALMS1P ARL6IP4 ATXN1L BTG3 C1QTNF4 CALN1 CCDC93 CHST10 CSE1L DCAF16 DRG2 FBXO41 FOXO3 FOXO6 GCC1 GGNBP2 HSF1 JMJD1C-AS1 MAPT METTL13 MGAT3 NEGR1 NKIRAS1 NPM3 NT5DC2 PEF1 PET112 PFDN1 PGPEP1 PPA2 PRADC1 PRKAG1 RNF123 RP11-571M6.17 RP11-73M18.8 RPS26 SORT1 ST3GAL3 SULT1A2 TANK TMEM170B U91328.21
Illnesses of siblings 1.51 1 0 0.0 0.00 1.0e+00 ST3GAL3
Neuroticism score 2.28 5 1 3.0 0.60 2.9e-01 C1QTNF4 FAM120AOS LRRC4 MAPT RNF123
Weight 2.52 15 11 33.3 -0.02 9.3e-01 AKTIP ATXN1L C1QTNF4 C2orf69 CMAHP DCAF16 FOXO3 GGNBP2 NEGR1 PEF1 PPA2 RNF123 RPS26 SULT1A2 WDR55
Impedance of arm (right) 2.14 13 10 30.3 -0.04 8.8e-01 CYP2D6 FOXO3 GCC1 JMJD1C-AS1 MAPT NEGR1 NT5DC2 PEF1 PRKAG1 RNF123 RP11-571M6.17 RPS26 SORT1
Arm fat percentage (right) 2.70 9 6 18.2 0.63 5.0e-02 C1QTNF4 CHST10 DCAF16 FOXO3 GGNBP2 NEGR1 RMDN1 RNF123 SULT1A2
Trunk fat-free mass 2.82 20 12 36.4 -0.44 5.3e-02 AKTIP ATXN1L C1QTNF4 C2orf69 CSE1L CYP2D6 DCAF16 FOXO3 GCC1 MGAT3 NEGR1 PEF1 PET112 PPA2 RNF123 RPS26 SORT1 SULT1A2 UBXN2A WDR55
Hip circumference 2.47 12 7 21.2 0.17 6.0e-01 AKTIP C1QTNF4 CMAHP DCAF16 DRG2 FOXO3 GGNBP2 NEGR1 PEF1 RNF123 SULT1A2 WDR55
Alcohol intake versus 10 years previously 1.87 2 1 3.0 0.00 1.0e+00 NEGR1 RNF123
Father's age at death 1.47 1 0 0.0 0.00 1.0e+00 RNF123
Worrier / anxious feelings 3.07 6 4 12.1 0.99 1.6e-09 C2orf69 GCC1 LRRC4 MAPT NT5DC2 SND1
Frequency of tiredness / lethargy in last 2 weeks 2.07 2 0 0.0 0.00 1.0e+00 CSE1L JMJD1C-AS1
Hair/balding pattern: Pattern 3 1.78 1 1 3.0 0.00 1.0e+00 MAPT
Forced expiratory volume in 1-second (FEV1) 2.80 10 6 18.2 -0.64 4.8e-02 C1QTNF4 CSE1L DCAF16 MAPT PEF1 PPA2 RNF123 RPS26 U91328.21 UBXN2A
Pulse rate 1.40 1 1 3.0 0.00 1.0e+00 AKTIP
Qualifications: A levels/AS levels or equivalent 6.01 30 8 24.2 -0.97 4.2e-20 AKTIP ALMS1 ALMS1P ARL6IP4 CALN1 CEP57 CHST10 CSE1L DBN1 DCAF16 DISP2 FAM120AOS FBXO41 FOXO6 JMJD1C-AS1 MAP1S MAPT MGAT3 NEGR1 NPM3 PEF1 PET112 PPA2 PRADC1 RNF123 RP11-73M18.8 RPS26 ST3GAL3 SULT1A2 TANK
Mouth/teeth dental problems: Dentures 1.41 1 0 0.0 0.00 1.0e+00 RNF123
Asthma 1.86 3 2 6.1 0.00 1.0e+00 AFF3 RPS26 U91328.21
Medication: Ibuprofen (e.g. Nurofen) 1.62 1 0 0.0 0.00 1.0e+00 U91328.21
Prospective memory result 2.76 1 0 0.0 0.00 1.0e+00 PEF1
Forced expiratory volume in 1-second (FEV1), Best measure 2.87 10 8 24.2 -0.65 4.2e-02 C1QTNF4 CSE1L DCAF16 MAPT PPA2 RNF123 RPS26 U91328.21 UBXN2A WDR55
Impedance of arm (left) 2.11 11 9 27.3 -0.15 6.7e-01 FOXO3 GGNBP2 JMJD1C-AS1 MAPT NEGR1 NT5DC2 PEF1 RNF123 RP11-571M6.17 RPS26 SORT1
Arm fat mass (right) 2.63 10 6 18.2 0.57 6.8e-02 C1QTNF4 CHST10 CMAHP FOXO3 GGNBP2 NEGR1 RMDN1 RNF123 RPS26 SULT1A2
Trunk predicted mass 2.84 20 12 36.4 -0.44 5.3e-02 AKTIP ATXN1L C1QTNF4 C2orf69 CSE1L CYP2D6 DCAF16 FOXO3 GCC1 MGAT3 NEGR1 PEF1 PET112 PPA2 RNF123 RPS26 SORT1 SULT1A2 UBXN2A WDR55
Standing height 2.54 20 15 45.5 -0.61 4.6e-03 AKTIP ARL6IP4 ATXN1L C1QTNF4 CSE1L DCAF16 DRG2 FOXO3 MAPT METTL13 NKIRAS1 NT5DC2 PEF1 PET112 PPA2 RP11-571M6.17 RP11-73M18.8 SULT1A2 UBXN2A WDR55
Exposure to tobacco smoke at home 1.55 1 0 0.0 0.00 1.0e+00 RNF123
Seen doctor (GP) for nerves, anxiety, tension or depression 2.19 3 1 3.0 0.00 1.0e+00 NEGR1 RP11-73M18.8 U91328.21
Hair/balding pattern: Pattern 4 1.70 1 1 3.0 0.00 1.0e+00 MAPT
Birth weight of first child 2.70 5 1 3.0 -0.47 4.3e-01 DCAF16 PPA2 RPS26 SND1 SULT1A2
Peak expiratory flow (PEF) 1.78 6 2 6.1 -0.71 1.2e-01 DCAF16 FOXO3 MAPT PEF1 U91328.21 UBXN2A
Qualifications: O levels/GCSEs or equivalent 3.70 6 1 3.0 -0.96 2.2e-03 ALMS1P CSE1L MAPT PET112 RNF123 ST3GAL3
Mouth/teeth dental problems: Bleeding gums 2.70 2 0 0.0 0.00 1.0e+00 PPA2 SND1
Medication: Paracetamol 2.47 2 2 6.1 0.00 1.0e+00 MAPT U91328.21
Headache pain in last month 2.01 4 2 6.1 0.99 1.2e-02 MAPT NT5DC2 RPS26 U91328.21
Medication for cholesterol, blood pressure or diabetes 1.78 1 0 0.0 0.00 1.0e+00 PRADC1
Hypothyroidism/myxoedema (self-reported) 1.54 2 1 3.0 0.00 1.0e+00 RPS26 TANK
Medication: Ventolin 100micrograms inhaler 1.72 1 0 0.0 0.00 1.0e+00 RPS26
Birth weight 3.62 6 2 6.1 0.47 9.3e-02 C1QTNF4 DCAF16 GCC1 LRRC4 SND1 UBXN2A
High blood pressure (siblings) 1.91 1 0 0.0 0.00 1.0e+00 TMEM170B
Forced vital capacity (FVC), Best measure 2.78 10 7 21.2 -0.84 2.3e-03 ATXN1L C1QTNF4 CSE1L DCAF16 MAPT PPA2 RNF123 U91328.21 UBXN2A WDR55
Body fat percentage 2.58 11 5 15.2 0.61 3.3e-02 C1QTNF4 CEP57 CHST10 CMAHP DCAF16 FOXO3 GGNBP2 NEGR1 RMDN1 RNF123 SULT1A2
Leg fat percentage (right) 2.85 14 8 24.2 0.67 6.0e-03 ARL6IP4 C1QTNF4 CEP57 CHST10 CSE1L DCAF16 FOXO3 GGNBP2 NEGR1 PGPEP1 RMDN1 RNF123 SULT1A2 UBXN2A
Arm fat-free mass (right) 2.73 16 12 36.4 -0.37 1.6e-01 AKTIP ATXN1L C2orf69 CYP2D6 DCAF16 FOXO3 MGAT3 NEGR1 PEF1 PPA2 RNF123 RPS26 SORT1 SULT1A2 UBXN2A WDR55
Comparative body size at age 10 2.98 8 6 18.2 -0.05 9.0e-01 C1QTNF4 FAM120AOS GGNBP2 NEGR1 PRKAG1 RMDN1 SULT1A2 U91328.21
Worry too long after embarrassment 1.53 3 0 0.0 0.00 1.0e+00 DBN1 PFDN1 PPA2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.95 1 0 0.0 0.00 1.0e+00 RP11-73M18.8
Wheeze or whistling in the chest in last year 1.76 2 1 3.0 0.00 1.0e+00 AFF3 RNF123
Age at first live birth 2.48 3 1 3.0 0.00 1.0e+00 DCAF16 RNF123 RPS26
Qualifications: College or University degree 7.39 40 25 75.8 -0.97 1.5e-27 AFF3 AKTIP ALMS1 ALMS1P ARL6IP4 ATXN1L CALN1 CCDC93 CEP57 CHST10 CSE1L DBN1 DCAF16 DRG2 FAM120AOS FBXO41 FOXO3 FOXO6 GGNBP2 HSF1 JMJD1C-AS1 MAPT MGAT3 NEGR1 NKIRAS1 NPM3 PET112 PFDN1 PPA2 PRADC1 RMDN1 RNF123 RP11-73M18.8 RPS26 SND1 SORT1 ST3GAL3 SULT1A2 TANK UBXN2A
Medication for pain relief, constipation, heartburn 2.24 2 2 6.1 0.00 1.0e+00 MAPT U91328.21
Neck or shoulder pain in last month 2.05 2 1 3.0 0.00 1.0e+00 ATXN1L RPS26
Medication: Blood pressure 1.78 3 0 0.0 1.00 4.3e-04 DCAF16 FBXO41 PRADC1
Medication: Seretide 50 evohaler 1.43 1 0 0.0 0.00 1.0e+00 RNF123
Mean time to correctly identify matches 2.39 6 3 9.1 -0.30 5.7e-01 C2orf69 CSE1L FOXO3 PFDN1 PRKAG1 SND1
Whole body fat mass 2.50 10 6 18.2 0.54 8.9e-02 C1QTNF4 CHST10 CMAHP FOXO3 GGNBP2 NEGR1 PGPEP1 RMDN1 RNF123 SULT1A2
Leg fat mass (right) 2.71 12 7 21.2 0.53 6.2e-02 C1QTNF4 CHST10 CMAHP FOXO3 GGNBP2 NEGR1 PEF1 PGPEP1 RMDN1 RNF123 RPS26 SULT1A2
Arm predicted mass (right) 2.75 17 12 36.4 -0.41 1.0e-01 AKTIP ATXN1L C2orf69 CSE1L CYP2D6 DCAF16 FOXO3 MGAT3 NEGR1 PEF1 PPA2 RNF123 RPS26 SORT1 SULT1A2 UBXN2A WDR55
Pulse rate, automated reading 1.41 5 2 6.1 0.50 3.9e-01 AKTIP NEGR1 PRKAG1 RNF123 RPS26
Alcohol intake frequency. 2.62 10 4 12.1 0.76 1.0e-02 AFF3 C1QTNF4 DRG2 MAPT NEGR1 PPA2 RNF123 RPS26 SULT1A2 UBXN2A
Comparative height size at age 10 2.26 16 11 33.3 -0.43 1.0e-01 AKTIP ARL6IP4 ATXN1L C1QTNF4 CSE1L DCAF16 DRG2 FOXO3 MAPT METTL13 PET112 PPA2 RP11-73M18.8 SULT1A2 U91328.21 UBXN2A
Suffer from 'nerves' 1.99 2 2 6.1 0.00 1.0e+00 C1QTNF4 SULT1A2
Overall health rating 2.23 5 3 9.1 0.99 7.7e-04 AKTIP ATXN1L FAM120AOS RNF123 TANK
Age at last live birth 2.08 1 1 3.0 0.00 1.0e+00 RNF123
Leg pain on walking 1.34 1 0 0.0 0.00 1.0e+00 RNF123
Qualifications: NVQ or HND or HNC or equivalent 1.58 1 0 0.0 0.00 1.0e+00 PIGO
Commuting to job workplace: Car/motor vehicle 2.20 1 0 0.0 0.00 1.0e+00 NEGR1
Hypertension (Self-reported) 1.70 6 1 3.0 0.47 3.5e-01 AKTIP CEP57 DCAF16 FBXO41 NEGR1 RPS26
Illnesses of father: Heart disease 1.24 1 0 0.0 0.00 1.0e+00 MAP1S
Forced expiratory volume in 1-second (FEV1), predicted 1.86 2 1 3.0 0.00 1.0e+00 C1QTNF4 DCAF16
Whole body fat-free mass 2.76 18 12 36.4 -0.39 1.1e-01 AKTIP ATXN1L C2orf69 CSE1L CYP2D6 DCAF16 FOXO3 GCC1 MGAT3 NEGR1 PEF1 PPA2 RNF123 RPS26 SORT1 SULT1A2 UBXN2A WDR55
Leg fat-free mass (right) 2.61 16 12 36.4 -0.35 1.8e-01 AKTIP ATXN1L C2orf69 DCAF16 FOXO3 GCC1 MGAT3 NEGR1 PEF1 PPA2 RNF123 RPS26 SORT1 SULT1A2 UBXN2A WDR55
Arm fat percentage (left) 2.67 8 6 18.2 0.68 4.3e-02 C1QTNF4 CHST10 DCAF16 GGNBP2 NEGR1 RMDN1 RNF123 SULT1A2
Handedness (chirality/laterality): Left-handed 1.80 2 1 3.0 0.00 1.0e+00 MAPT SULT1A2
Mood swings 2.00 3 2 6.1 0.00 1.0e+00 FAM120AOS MAPT RNF123
Loneliness, isolation 2.33 4 2 6.1 -0.15 8.5e-01 C1QTNF4 CSE1L FAM120AOS JMJD1C-AS1
Long-standing illness, disability or infirmity 1.52 2 0 0.0 0.00 1.0e+00 NEGR1 RP11-73M18.8
Diabetes diagnosed by doctor 1.23 1 0 0.0 0.00 1.0e+00 AKTIP
Qualifications: nursing, teaching 3.60 7 2 6.1 -0.99 3.9e-05 ALMS1 CEP57 JMJD1C-AS1 NEGR1 PPA2 RNF123 ST3GAL3
Mouth/teeth dental problems: Mouth ulcers 1.55 1 1 3.0 0.00 1.0e+00 MAPT
Medication for cholesterol 1.56 2 0 0.0 0.00 1.0e+00 AKTIP MAPT
Mineral and other dietary supplements 1.45 1 0 0.0 0.00 1.0e+00 CMAHP
Asthma (self-reported) 1.72 4 2 6.1 -0.52 4.8e-01 AFF3 RPS26 U91328.21 WDR55
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.99 2 2 6.1 0.00 1.0e+00 MAPT U91328.21
Whole body water mass 2.77 18 12 36.4 -0.39 1.1e-01 AKTIP ATXN1L C2orf69 CSE1L CYP2D6 DCAF16 FOXO3 GCC1 MGAT3 NEGR1 PEF1 PPA2 RNF123 RPS26 SORT1 SULT1A2 UBXN2A WDR55
Leg predicted mass (right) 2.60 17 11 33.3 -0.39 1.2e-01 AKTIP ATXN1L C2orf69 CSE1L DCAF16 FOXO3 GCC1 MGAT3 NEGR1 PEF1 PPA2 RNF123 RPS26 SORT1 SULT1A2 UBXN2A WDR55
Arm fat mass (left) 2.60 9 6 18.2 0.60 6.7e-02 C1QTNF4 CHST10 FOXO3 GGNBP2 NEGR1 RMDN1 RNF123 RPS26 SULT1A2
Number of self-reported non-cancer illnesses 2.01 3 1 3.0 0.40 6.0e-01 FBXO41 NEGR1 PRADC1
Average weekly champagne plus white wine intake 1.83 1 0 0.0 0.00 1.0e+00 MAPT
Miserableness 2.02 2 1 3.0 0.00 1.0e+00 RNF123 TANK
Guilty feelings 2.22 1 0 0.0 0.00 1.0e+00 UBXN2A
Financial situation satisfaction 1.59 1 0 0.0 0.00 1.0e+00 RNF123
Commuting to job workplace: Public transport 2.72 2 0 0.0 0.00 1.0e+00 CHST10 NEGR1
Medication: Blood pressure 1.46 1 0 0.0 0.00 1.0e+00 MAPT
High cholesterol (Self-reported) 1.10 1 0 0.0 0.00 1.0e+00 DCAF16
Medication: Paracetamol 2.20 2 1 3.0 0.00 1.0e+00 MAPT U91328.21
Basal metabolic rate 2.67 16 12 36.4 -0.35 1.9e-01 AKTIP ATXN1L C2orf69 DCAF16 FOXO3 GGNBP2 MGAT3 NEGR1 PEF1 PPA2 RNF123 RPS26 SORT1 SULT1A2 UBXN2A WDR55
Leg fat percentage (left) 2.99 14 8 24.2 0.67 6.3e-03 ARL6IP4 C1QTNF4 CEP57 CHST10 CSE1L DCAF16 FOXO3 GGNBP2 NEGR1 PGPEP1 RMDN1 RNF123 SULT1A2 UBXN2A
Arm fat-free mass (left) 2.72 17 12 36.4 -0.30 2.5e-01 AKTIP ATXN1L C2orf69 CYP2D6 DCAF16 FOXO3 GGNBP2 MGAT3 NEGR1 PEF1 PPA2 RNF123 RPS26 SORT1 SULT1A2 UBXN2A WDR55
Number of operations (self-reported) 1.82 2 1 3.0 0.00 1.0e+00 PPA2 TANK
Average weekly beer plus cider intake 1.67 1 0 0.0 0.00 1.0e+00 RNF123
Irritability 1.31 1 0 0.0 0.00 1.0e+00 MAPT
Risk taking 3.12 3 1 3.0 -0.53 4.7e-01 GCC1 PET112 SND1
Diastolic blood pressure, automated reading 1.79 9 5 15.2 0.98 3.4e-06 ALMS1 ALMS1P ARL6IP4 DCAF16 FBXO41 PRADC1 RNF123 RPS26 U91328.21
Ever depressed for a whole week 1.85 2 0 0.0 0.00 1.0e+00 CSE1L RP11-73M18.8
Myopia 1.62 1 0 0.0 0.00 1.0e+00 C1QTNF4
Vascular/heart problems diagnosed by doctor 1.75 4 1 3.0 -0.48 4.1e-01 DCAF16 FBXO41 NEGR1 PRADC1
Cholesterol lowering medication 1.39 1 0 0.0 0.00 1.0e+00 DCAF16
Pain experienced in last month 2.00 3 1 3.0 0.00 1.0e+00 ATXN1L RNF123 RPS26
Alcohol drinker status: Previous 1.12 1 0 0.0 0.00 1.0e+00 RP11-73M18.8
Pack years of smoking 1.55 1 1 3.0 0.00 1.0e+00 JMJD1C-AS1
Impedance of whole body 2.19 16 9 27.3 -0.06 8.3e-01 C2orf69 FOXO3 GCC1 GGNBP2 JMJD1C-AS1 MAPT NEGR1 NT5DC2 PEF1 PFDN1 PRKAG1 RNF123 RP11-571M6.17 RPS26 SND1 SORT1
Leg fat mass (left) 2.80 12 7 21.2 0.53 6.2e-02 C1QTNF4 CHST10 CMAHP FOXO3 GGNBP2 NEGR1 PEF1 PGPEP1 RMDN1 RNF123 RPS26 SULT1A2
Arm predicted mass (left) 2.70 16 12 36.4 -0.35 1.9e-01 AKTIP ATXN1L C2orf69 DCAF16 FOXO3 GGNBP2 MGAT3 NEGR1 PEF1 PPA2 RNF123 RPS26 SORT1 SULT1A2 UBXN2A WDR55

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 24 0.687 2.42
GTEx Adipose Visceral Omentum 12 0.589 2.45
GTEx Adrenal Gland 6 0.412 2.33
GTEx Artery Aorta 29 0.973 2.56
GTEx Artery Coronary 8 0.675 2.38
GTEx Artery Tibial 33 0.877 2.48
GTEx Brain Caudate basal ganglia 6 0.651 2.52
GTEx Brain Cerebellar Hemisphere 11 0.738 2.59
GTEx Brain Cerebellum 13 0.655 2.57
GTEx Brain Cortex 14 1.351 2.67
GTEx Brain Frontal Cortex BA9 5 0.540 2.66
GTEx Brain Hippocampus 3 0.570 2.60
GTEx Brain Hypothalamus 3 0.508 2.53
GTEx Brain Nucleus accumbens basal ganglia 8 0.924 2.45
GTEx Brain Putamen basal ganglia 5 0.800 2.63
GTEx Breast Mammary Tissue 18 0.911 2.56
GTEx Breast Mammary Tissue (Male) 8 0.670 2.44
GTEx Breast Mammary Tissue (Female) 12 0.729 2.48
GTEx Cells EBV-transformed lymphocytes 12 0.843 2.72
GTEx Cells Transformed fibroblasts 33 0.786 2.45
GTEx Colon Sigmoid 16 1.094 2.68
GTEx Colon Transverse 17 0.822 2.60
GTEx Esophagus Gastroesophageal Junction 16 1.106 2.78
GTEx Esophagus Mucosa 26 0.783 2.59
GTEx Esophagus Muscularis 29 0.897 2.60
GTEx Heart Atrial Appendage 18 1.139 2.59
GTEx Heart Left Ventricle 15 0.978 2.56
GTEx Liver 5 0.696 2.57
GTEx Lung 23 0.800 2.53
GTEx Muscle Skeletal 24 0.830 2.55
GTEx Nerve Tibial 31 0.717 2.42
GTEx Ovary 9 0.989 2.76
GTEx Pancreas 9 0.551 2.49
GTEx Pituitary 8 0.717 2.42
GTEx Prostate 6 0.719 2.50
GTEx Skin Not Sun Exposed Suprapubic 18 0.731 2.57
GTEx Skin Sun Exposed Lower leg 29 0.797 2.59
GTEx Small Intestine Terminal Ileum 3 0.649 2.64
GTEx Spleen 12 0.850 2.66
GTEx Stomach 11 0.755 2.61
GTEx Testis 23 0.729 2.41
GTEx Thyroid 23 0.575 2.40
GTEx Uterus 1 0.176 2.51
GTEx Vagina 7 1.101 2.95
GTEx Whole Blood 12 0.602 2.53
METSIM Adipose 26 0.564 2.18
NTR Blood 14 0.582 2.33
ROSMAP Brain Pre-frontal Cortex 31 0.706 2.45
YFS Blood 23 0.498 2.22
CommonMind Brain Pre-frontal Cortex 30 0.558 2.36
TCGA Breast Tumor 2 0.261 2.35
TCGA Breast Normal 14 0.333 2.06
TCGA Ovarian Tumor 10 0.342 2.15
TCGA Prostate Tumor 17 0.491 2.18