TWAS hub - NKX2-8

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Head and Neck Squamous Cell Carcinoma	0.0363	0.0216	0.0008	0.026	0.023	0.009	NA	0.011	0.00061	0.0010	0.033	NA	0.017
2	TCGA	Lung Squamous Cell Carcinoma	0.0310	0.0184	0.0023	0.019	0.018	0.002	NA	0.010	0.00280	0.0033	0.170	NA	0.025

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Verbal and Numeric Reasoning (VNR)	10.9	26.2	27.3	5.0	5.2
Breast Cancer	9.9	23.8	24.7	-4.8	-5.0
Intelligence (Savage-Jansen 2018)	8.2	25.3	26.8	4.9	5.2
Neck or shoulder pain in last month	6.9	9.8	10.7	3.3	3.0
Fluid intelligence score	6.7	13.8	14.1	3.7	3.8
Medication: Aspirin	5.2	6.8	7.4	-2.5	-2.7
Medication: Aspirin	5.0	6.5	6.8	-2.5	-2.6
Commuting to job workplace: Public transport	4.8	5.7	6.3	2.5	2.2
Supplements: Vitamin C	4.5	5.3	6.8	-2.0	-2.6
Mouth/teeth dental problems: Bleeding gums	4.3	5.6	5.9	-2.4	-2.3
Migraine (self-reported)	4.1	5.0	7.1	2.7	1.7
Frequency of tiredness / lethargy in last 2 weeks	4.0	6.5	6.8	2.6	2.5
Lung FEV1/FVC ratio	3.7	19.0	21.7	-4.0	-4.7
Severe depression (siblings)	3.7	4.2	4.8	1.9	2.2
Supplements: Zinc	3.4	3.6	4.0	-1.8	-2.0
Chest pain or discomfort	3.4	4.8	5.9	1.9	2.4
Alzheimer’s Disease (in father)	3.2	3.4	4.2	-1.6	-2.0
Average weekly fortified wine intake	3.1	3.7	3.7	-1.9	-1.9
Miserableness	3.1	5.4	7.1	2.7	1.9
Prostate Cancer	2.9	4.0	5.2	-1.7	-2.3
Knee pain experienced in last month	2.8	4.3	5.0	2.2	1.9
Bilateral oophorectomy (both ovaries removed)	2.6	2.9	3.8	1.9	1.5
Alzheimer’s Disease (in mother)	2.5	2.9	3.4	1.6	1.8
Alcohol intake versus 10 years previously	2.5	3.8	4.3	1.8	2.1
Average weekly beer plus cider intake	2.5	3.6	4.2	1.7	2.1
Heart attack	2.4	3.1	3.8	-1.9	-1.5
Standing height	2.4	24.1	25.5	5.0	4.8
Long-standing illness, disability or infirmity	2.4	3.7	4.0	2.0	1.8
Mineral and other dietary supplements	2.4	3.2	3.8	1.6	2.0
Medication: Cholesterol lowering	2.3	3.6	3.8	-1.9	-2.0
Forced expiratory volume in 1-second (FEV1), predicted	2.3	4.8	5.0	2.2	2.1
Qualifications: CSEs or equivalent	2.2	2.9	3.2	-1.8	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	2.2	5.0	7.1	-2.7	-1.7
Medication: Simvastatin	2.2	3.2	3.8	-1.9	-1.6
Wheeze or whistling in the chest in last year	2.2	3.9	4.5	2.1	1.8
Heart attack/myocardial infarction (self-reported)	2.2	2.9	3.8	-2.0	-1.4
Trunk fat percentage	2.1	8.5	10.5	2.6	3.2
Trunk fat mass	2.1	9.1	11.0	2.7	3.3
Happiness	2.1	2.5	3.1	1.4	1.8
Number of children fathered	2.0	2.2	2.7	-1.6	-1.3
Fractured/broken bones in last 5 years	2.0	2.5	2.8	1.7	1.5
Pain experienced in last month	2.0	3.4	4.2	-2.0	-1.6
Heel T-Score	1.9	14.7	17.1	-4.1	-3.5
Height	1.9	37.1	38.6	6.2	6.0
Townsend deprivation index at recruitment	1.9	2.6	3.0	1.7	1.5
Asthma	1.9	3.7	4.0	1.8	2.0
Prospective memory result	1.9	2.4	3.8	-1.9	-1.0
Breast cancer (self-reported)	1.9	2.2	2.7	1.6	1.3
Asthma (self-reported)	1.9	3.7	4.0	1.9	2.0
Ulcerative Colitis (UC)	1.8	3.4	3.5	-1.9	-1.8
Ever had hysterectomy (womb removed)	1.8	2.1	3.0	1.7	1.1
Number of incorrect matches in round	1.8	3.1	3.6	-1.9	-1.6
Body fat percentage	1.8	7.2	8.9	2.3	3.0
Eye problems/disorders: None of the above	1.8	2.1	3.0	-1.7	-1.1
Whole body fat mass	1.8	7.6	9.2	2.5	3.0
Supplements: Fish oil (including cod liver oil)	1.8	2.4	2.4	-1.6	-1.5
Supplements: Calcium	1.8	2.0	2.5	-1.6	-1.2
Type 2 Diabetes (T2D) (2018)	1.7	3.1	3.2	1.8	1.8
Waist circumference	1.7	6.2	7.3	2.3	2.7
Qualifications: None of the above	1.7	3.7	5.2	-1.5	-2.3
Gout (self-reported)	1.7	2.3	2.5	1.4	1.6
Medication: Allopurinol	1.7	2.3	2.5	1.4	1.6
Diabetes diagnosed by doctor	1.7	2.8	2.9	1.6	1.7
Qualifications: nursing, teaching	1.7	2.6	4.3	2.1	0.9
Back pain experienced in last month	1.7	2.4	2.7	1.6	1.5
Age started oral contraceptive pill	1.7	2.2	2.3	1.4	1.5
Frequency of depressed mood in last 2 weeks	1.6	2.2	2.8	1.3	1.7
Hair/balding pattern: Pattern 4	1.6	3.9	4.2	-2.0	-1.9
Medication for cholesterol, blood pressure or diabetes	1.6	2.7	3.0	1.6	1.7
Age at First Birth	1.5	2.2	2.4	1.4	1.6
Vitamin and mineral supplements	1.5	2.0	2.5	1.2	1.6
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.3	5.7	-2.4	-0.9
Medication: Ventolin 100micrograms inhaler	1.5	1.9	2.3	1.5	1.2
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	2.0	1.2	1.4
Diabetes (mother)	1.4	1.8	2.1	1.2	1.5
Weight	1.4	6.8	8.1	2.3	2.8
Illnesses of siblings: Diabetes	1.4	1.8	2.6	1.0	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	3.1	3.3	-1.8	-1.7
Bipolar Disorder (2018)	1.3	2.0	2.2	-1.5	-1.4
Rheumatoid Arthritis	1.3	1.8	2.2	1.2	1.5
Respiratory disease	1.3	2.8	3.5	1.4	1.9
Neuroticism	1.3	3.1	3.4	1.6	1.9
Stomach or abdominal pain in last month	1.3	1.6	2.8	1.7	0.6
Emphysema/chronic bronchitis	1.3	1.5	1.5	1.2	1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	2.0	-0.9	-1.4
Medication: Paracetamol	1.3	2.1	2.9	1.7	1.1
Angina	1.2	1.6	2.2	-1.5	-1.0
Fed-up feelings	1.2	2.1	2.3	1.5	1.4
Multivitamins +/- minerals	1.2	1.5	2.1	-1.0	-1.4
Sitting height	1.2	8.2	9.8	2.6	3.1
High blood pressure (mother)	1.2	1.6	2.2	-1.5	-1.0
Allergy	1.2	2.8	3.2	-1.5	-1.8
Impedance of arm (right)	1.2	5.8	6.0	2.5	2.4
Arm fat mass (right)	1.2	5.0	6.6	1.9	2.6
Waist Hip Ratio (WHR)	1.1	4.8	5.3	2.3	2.1
Supplements: Glucosamine	1.1	1.5	1.7	-1.1	-1.3
Had other major operations	1.1	1.3	1.7	-1.0	-1.3
Hip circumference	1.1	4.9	6.0	1.9	2.4
Exposure to tobacco smoke at home	1.1	1.2	1.3	1.2	1.1
High blood pressure (siblings)	1.1	1.7	2.9	0.7	1.7
Health satisfaction	1.1	1.4	1.9	1.4	0.9
Impedance of whole body	1.1	5.8	6.2	2.5	2.3
Bipolar Disorder (2011)	1.0	1.0	1.5	-0.7	-1.2
Body Mass Index (BMI) (2010)	1.0	1.3	1.3	1.1	1.2
Lung cancer (father)	1.0	1.2	1.4	1.0	1.2
Impedance of arm (left)	1.0	4.7	4.8	2.1	2.2
Loud music exposure frequency	1.0	1.1	1.7	1.3	0.6
Number of full brothers	1.0	1.3	1.3	1.1	1.2
Suffer from ‘nerves’	1.0	1.5	1.7	-1.3	-1.1
Wears glasses or contact lenses	1.0	1.1	1.8	1.3	0.6
Unable to work because of sickness or disability	1.0	1.3	2.1	-0.8	-1.4
Leg fat-free mass (left)	0.9	4.8	5.4	2.0	2.3
Leg predicted mass (left)	0.9	4.9	5.4	2.1	2.3
Hair/balding pattern: Pattern 2	0.9	1.1	1.9	0.6	1.4
Medication: Ramipril	0.9	1.1	1.8	-1.3	-0.6
Arm fat percentage (right)	0.9	3.6	5.2	1.4	2.3
Medication: Paracetamol	0.9	1.5	2.1	1.5	1.0
Forced vital capacity (FVC), Best measure	0.9	3.4	5.0	1.4	2.2
Angina (self-reported)	0.9	1.2	1.9	-1.4	-0.8
Leg fat mass (right)	0.9	3.6	4.5	1.6	2.1
Comparative height size at age 10	0.9	5.2	5.3	2.3	2.3
Arm fat percentage (left)	0.9	3.5	5.0	1.4	2.2
Friendships satisfaction	0.9	1.1	1.3	1.0	1.1
Arm fat mass (left)	0.9	3.6	4.8	1.5	2.2
Basal metabolic rate	0.9	5.0	5.6	2.1	2.4
Relative age voice broke	0.8	1.2	1.3	1.1	1.1
Breastfed as a baby	0.8	1.0	1.2	-0.9	-1.1
Medication: Omeprazole	0.8	1.0	1.5	0.7	1.2
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	1.1	0.9	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.0	1.0	0.9
Leg fat-free mass (right)	0.8	4.1	4.5	1.9	2.1
Leg predicted mass (right)	0.8	4.0	4.5	1.9	2.1
Average weekly champagne plus white wine intake	0.8	1.1	1.4	0.9	1.2
Financial situation satisfaction	0.8	1.0	1.3	-0.9	-1.1
Pack years of smoking	0.8	1.2	1.9	1.4	0.7
Leg fat mass (left)	0.8	3.3	4.2	1.6	2.0
Depressed Affect (Nagel 2018)	0.7	1.5	1.7	1.3	1.2
HDL Cholesterol	0.7	1.1	1.5	1.2	0.8
Sensitivity / hurt feelings	0.7	1.3	1.8	0.9	1.3
Relative age of first facial hair	0.7	1.5	2.0	1.4	0.9
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.2	1.1	0.7
Pack years adult smoking proportion	0.7	1.1	1.9	1.4	0.6
Impedance of leg (right)	0.7	3.3	3.8	1.9	1.7
Impedance of leg (left)	0.7	3.3	4.0	2.0	1.6
Leg fat percentage (right)	0.7	2.6	3.4	1.3	1.8
Shortness of breath walking on level ground	0.7	0.8	1.0	0.8	1.0
Medication: Blood pressure	0.7	1.3	1.4	-1.1	-1.2
Family relationship satisfaction	0.7	0.9	1.1	0.8	1.1
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.0	-1.0	-0.7
Ever had bowel cancer screening	0.7	0.8	0.8	-0.9	-0.9
Osteoporosis (self-reported)	0.7	0.9	1.3	1.1	0.7
Whole body water mass	0.7	3.9	4.2	1.9	2.0
Alcohol drinker status: Never	0.7	0.8	1.2	-0.6	-1.1
Arm fat-free mass (left)	0.7	3.6	3.8	1.8	1.9
Basal cell carcinoma (self-reported)	0.7	0.9	1.1	1.0	0.8
Heart disease (siblings)	0.7	0.8	1.0	-0.8	-1.0
Bipolar Disorder or Schizophrenia	0.6	1.6	2.0	-1.1	-1.4
Average weekly spirits intake	0.6	0.7	1.1	-0.6	-1.0
Mouth/teeth dental problems	0.6	0.9	1.3	1.1	0.7
Time employed in main current job	0.6	0.7	0.9	-0.7	-0.9
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	1.1	0.9	1.1
Arm predicted mass (right)	0.6	2.9	3.2	1.6	1.8
Pulse rate, automated reading	0.6	1.9	2.4	-1.2	-1.5
Number of full sisters	0.6	0.7	1.0	0.6	1.0
Leg pain on walking	0.6	0.8	0.9	-0.8	-1.0
Whole body fat-free mass	0.6	3.6	3.9	1.8	2.0
Hearing aid user	0.6	0.7	1.2	0.4	1.1
Mother’s age at death	0.6	0.8	0.9	0.8	1.0
Worry (Nagel 2018)	0.5	1.0	1.5	-1.2	-0.8
Crohns Disease (2012)	0.5	0.9	1.2	1.1	0.7
Schizophrenia (2014)	0.5	1.2	1.7	-0.8	-1.3
Lung FVC	0.5	2.7	4.1	-2.0	-1.1
Chronotype (morning person)	0.5	1.2	2.1	-1.4	0.5
Age when periods started (menarche)	0.5	1.2	1.2	-1.1	-1.1
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	0.6	-0.7	-0.8
Hayfever, allergic rhinitis or eczema	0.5	1.2	1.6	0.9	1.3
Forced vital capacity (FVC)	0.5	1.9	2.7	1.1	1.6
Diabetes (self-reported)	0.5	0.7	0.8	0.8	0.9
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	0.7	0.8	0.8
Pulse rate	0.5	0.8	0.8	-0.9	-0.9
Depression (self-reported)	0.5	0.6	0.6	-0.8	-0.8
Pulse wave Arterial Stiffness index	0.5	0.6	0.6	0.8	0.8
Medication: Amlodipine	0.5	0.7	1.2	-1.1	-0.4
Arm fat-free mass (right)	0.5	2.6	2.7	1.6	1.6
Number of self-reported non-cancer illnesses	0.5	0.8	1.0	0.8	1.0
High cholesterol (Self-reported)	0.5	0.9	1.4	-1.2	-0.6
Arm predicted mass (left)	0.5	2.7	3.0	1.6	1.7
HbA1C	0.4	0.4	0.8	0.9	0.3
Hand grip strength (right)	0.4	1.1	1.6	-1.3	-0.8
Maternal smoking around birth	0.4	0.5	0.6	-0.8	-0.7
Medication: Atenolol	0.4	0.6	0.6	-0.8	-0.7
Chronic bronchitis/emphysema (father)	0.4	0.5	0.7	0.5	0.8
Illnesses of siblings	0.4	0.6	1.1	-0.2	-1.0
Trunk fat-free mass	0.4	2.4	2.7	1.4	1.6
Trunk predicted mass	0.4	2.1	2.4	1.4	1.5
Pulse wave reflection index	0.4	0.5	0.6	0.8	0.7
Qualifications: College or University degree	0.4	1.1	1.2	1.1	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.5	-0.7	-0.7
Had major operations	0.4	0.4	0.8	-0.9	-0.2
Age at last live birth	0.4	0.5	0.8	0.9	0.5
Illnesses of father: None of the above (group 1)	0.4	0.4	0.5	-0.6	-0.7
Ever smoked	0.4	0.7	0.9	0.7	0.9
Leg fat percentage (left)	0.4	1.5	2.0	1.0	1.4
Diastolic blood pressure, automated reading	0.4	1.1	1.3	1.0	1.1
Alcohol drinker status: Previous	0.4	0.4	0.7	0.4	0.8
Mean Putamen Volume	0.3	0.4	0.5	-0.7	-0.5
LDL Cholesterol	0.3	0.4	0.5	-0.5	-0.7
Neuroticism (2016)	0.3	0.4	0.4	0.6	0.6
Medication: Metformin	0.3	0.4	0.6	0.5	0.7
Worrier / anxious feelings	0.3	0.5	0.9	-0.9	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.6	-0.5	-0.8
Medication: Lansoprazole	0.3	0.4	0.4	0.7	0.6
Blood clot in the leg (DVT)	0.3	0.4	0.4	-0.6	-0.6
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.4	0.6	0.6
Heart disease (mother)	0.3	0.3	0.5	-0.7	-0.4
Alcohol intake frequency.	0.3	0.7	0.8	-0.9	-0.9
Smoking status: Previous	0.3	0.4	0.9	0.0	0.9
Eye problems/disorders: Cataract	0.3	0.4	0.4	0.6	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.4	0.6	0.5
Ever taken oral contraceptive pill	0.3	0.3	0.6	0.8	0.3
Eye problems/disorders: Glaucoma	0.3	0.3	0.5	-0.7	-0.5
Illnesses of father: High blood pressure	0.3	0.4	0.5	0.7	0.5
Neuroticism (Nagel 2018)	0.2	0.4	0.5	0.5	0.7
Crohns Disease (2017)	0.2	0.3	0.4	0.7	0.5
Reaction Time	0.2	0.4	0.6	-0.4	-0.8
Ovarian Cancer	0.2	0.2	0.4	0.7	-0.0
Triglycerides	0.2	0.3	0.3	-0.5	-0.5
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.3	0.5	0.4
Ulcerative Colitis	0.2	0.3	0.3	-0.5	-0.6
Smoking Status	0.2	0.4	0.4	0.6	0.6
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	-0.0	-0.7
Medication for hormone replacement therapy	0.2	0.2	0.3	0.6	0.1
Taking other prescription medications	0.2	0.3	0.3	0.6	0.5
Medication: Levothyroxine sodium	0.2	0.4	0.7	0.4	0.8
Hearing difficulty/problems with background noise	0.2	0.3	0.6	-0.7	-0.3
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.5	0.0	-0.7
Financial difficulties in last 2 years	0.2	0.2	0.3	-0.6	-0.3
Neuroticism score	0.2	0.4	0.4	0.6	0.6
Number of live births	0.2	0.2	0.4	-0.3	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	0.9	0.2	1.0
Headache pain in last month	0.2	0.4	0.6	0.5	0.8
Birth weight	0.2	0.5	0.8	-0.9	-0.5
Exposure to tobacco smoke outside home	0.2	0.3	0.5	-0.7	-0.3
Medication for pain relief, constipation, heartburn	0.2	0.4	0.5	0.6	0.7
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.3	-0.5	-0.3
Commuting to job workplace: Walk	0.2	0.2	0.3	-0.3	-0.5
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.4	-0.6	0.2
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.5	0.7	-0.0
Medication: Bendroflumethiazide	0.2	0.2	0.2	-0.5	-0.5
Medication: Lisinopril	0.2	0.2	0.3	0.5	0.5
Number of operations (self-reported)	0.2	0.3	0.4	0.7	0.3
Irritability	0.2	0.4	0.6	0.8	0.4
Ever depressed for a whole week	0.2	0.2	0.5	0.7	0.0
Myopia	0.2	0.2	0.3	0.5	0.4
Cholesterol lowering medication	0.2	0.3	0.5	-0.7	0.1
Schizophrenia (2018)	0.1	0.3	0.5	-0.2	-0.7
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	0.1	0.5
Alzheimer’s Disease (including proxy)	0.1	0.2	0.2	-0.5	-0.4
Coronary Artery Disease (CAD)	0.1	0.1	0.1	0.1	-0.4
Fasting Glucose	0.1	0.1	0.2	0.4	-0.1
Lupus	0.1	0.2	0.3	-0.6	-0.3
Blood Eosinophil Count	0.1	1.0	1.2	0.9	1.1
Blood Red Count	0.1	0.5	0.8	0.5	0.9
BMI	0.1	0.5	0.7	0.5	0.8
Allergy or Eczema	0.1	0.3	0.5	0.3	0.7
Cardiovascular Disease	0.1	0.5	0.8	-0.4	-0.9
Hypothyroidism (self reported)	0.1	0.3	0.4	0.5	0.6
Tanning	0.1	0.9	1.1	-1.1	-0.8
Hand grip strength (left)	0.1	0.3	0.5	-0.7	-0.2
Number of treatments/medications taken	0.1	0.2	0.3	-0.5	-0.4
Hearing difficulty/problems: Yes	0.1	0.2	0.3	-0.6	0.1
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	0.4	0.2
Medication: Co-codamol	0.1	0.1	0.1	-0.2	-0.3
Current tobacco smoking	0.1	0.1	0.2	0.5	-0.2
Body mass index (BMI)	0.1	0.3	0.5	0.0	0.7
Past tobacco smoking	0.1	0.2	0.5	0.0	-0.7
Nervous feelings	0.1	0.2	0.4	-0.6	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.2	-0.4	-0.3
Had menopause	0.1	0.2	0.3	0.3	0.5
Father’s age at death	0.1	0.1	0.3	0.5	0.1
Falls in the last year	0.1	0.1	0.3	-0.0	-0.5
Hair/balding pattern: Pattern 3	0.1	0.1	0.1	-0.2	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	0.2	-0.4
Length of working week for main job	0.1	0.1	0.1	-0.1	0.4
Tense / ‘highly strung’	0.1	0.2	0.2	-0.4	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.2	-0.4
Glaucoma (self-reported)	0.1	0.1	0.2	0.2	0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.1	0.3	0.4
Pulse wave peak to peak time	0.1	0.2	0.2	-0.5	-0.4
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	-0.2	-0.4
Medication: Ibuprofen	0.1	0.1	0.2	0.2	-0.5
Medication: Seretide 50 evohaler	0.1	0.2	0.2	0.5	0.3
Overall health rating	0.1	0.2	0.4	0.6	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.1	-0.2	0.3
Average weekly red wine intake	0.1	0.1	0.1	-0.3	-0.3
Mood swings	0.1	0.1	0.3	-0.1	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.2	-0.0	0.4
Medication for cholesterol	0.1	0.2	0.3	0.3	-0.5
Smoking status: Current	0.1	0.2	0.4	0.6	0.0
Medication: Blood pressure	0.1	0.2	0.4	0.0	0.6
Risk taking	0.1	0.1	0.2	-0.1	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.1	-0.4	-0.3
Depression (Nagel 2018)	0.0	0.0	0.0	0.2	0.1
Irritable Bowel Disease (IBD)	0.0	0.1	0.1	-0.3	-0.4
Major Depression (MDD)	0.0	0.0	0.1	-0.2	0.0
Primary Biliary Cirrhosis	0.0	0.0	0.1	-0.3	-0.0
Blood Platelet Count	0.0	0.0	0.0	-0.0	0.1
Blood White Count	0.0	0.0	0.0	0.2	0.1
Systolic Blood Pressure	0.0	0.0	0.0	0.0	-0.1
Hair Pigment	0.0	0.3	0.6	-0.8	0.1
Systolic blood pressure, automated reading	0.0	0.0	0.0	-0.0	0.0
Diabetes (father)	0.0	0.0	0.0	-0.2	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.1	-0.0	0.2
Serious illness, injury or assault to yourself	0.0	0.0	0.1	0.2	-0.2
High blood pressure	0.0	0.1	0.1	0.2	0.4
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.1	-0.2	-0.1
Alcohol usually taken with meals	0.0	0.1	0.1	-0.1	-0.3
Pain all over the body in last month	0.0	0.0	0.1	-0.3	-0.0
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.1	0.0	0.4
Noisy workplace	0.0	0.0	0.0	0.0	0.2
Qualifications: A levels/AS levels or equivalent	0.0	0.0	0.1	0.3	-0.0
Mouth/teeth dental problems: Dentures	0.0	0.0	0.0	0.2	0.0
Illnesses of mother	0.0	0.0	0.0	0.2	-0.2
Birth weight of first child	0.0	0.0	0.1	0.0	0.3
Peak expiratory flow (PEF)	0.0	0.0	0.0	0.1	0.2
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.0	-0.0	-0.0
Comparative body size at age 10	0.0	0.0	0.1	-0.2	0.1
Worry too long after embarrassment	0.0	0.0	0.1	-0.0	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.0	0.2	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.1	0.3	0.1
Age at first live birth	0.0	0.0	0.0	-0.0	-0.2
Mean time to correctly identify matches	0.0	0.0	0.0	-0.1	-0.2
Hypertension (Self-reported)	0.0	0.0	0.0	-0.1	-0.0
Illnesses of father: Heart disease	0.0	0.0	0.0	0.0	-0.1
Loneliness, isolation	0.0	0.0	0.1	0.2	0.1
Osteoarthritis (self-reported)	0.0	0.0	0.0	0.2	0.1
Medication: Gliclazide	0.0	0.0	0.0	0.1	-0.2
Guilty feelings	0.0	0.1	0.1	-0.2	0.3
Medication: Atorvastatin	0.0	0.1	0.1	-0.2	-0.3
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.1	-0.1	0.3
Commuting to job workplace: Cycle	0.0	0.0	0.1	0.2	-0.2
Vascular/heart problems diagnosed by doctor	0.0	0.0	0.0	0.1	-0.1

Hub : Genes

NKX2-8

Models

Trait associations