Hub : Genes

PRKCQ

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0940 0.0320 0.00300 0.008 0.020 0.015 0.027 0.007 3.3e-02 0.00160 5.9e-03 2.9e-04 4.5e-02
2 YFS Blood 0.0438 0.0139 0.00035 0.025 0.011 0.022 0.021 0.025 7.4e-09 0.00012 8.5e-08 1.3e-07 9.7e-09

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.5 0.8 1.4 1.2 -0.4
Bipolar Disorder or Schizophrenia 0.9 2.2 2.2 1.5 -1.5
Depressed Affect (Nagel 2018) 0.1 0.3 0.5 -0.0 0.7
Depression (Nagel 2018) 0.4 0.6 0.9 -0.5 0.9
Intelligence (Savage-Jansen 2018) 0.5 1.7 3.1 1.7 0.5
Neuroticism (Nagel 2018) 1.0 2.4 2.5 -1.6 -1.5
Schizophrenia (2018) 0.6 1.2 2.1 0.6 -1.4
Schizophrenia vs Biploar Disorder 0.3 0.5 0.9 -0.2 -0.9
Worry (Nagel 2018) 2.1 4.3 6.2 -1.6 -2.5
Alzheimer’s Disease (in mother) 1.0 1.2 2.0 1.4 0.6
Alzheimer’s Disease (in father) 0.6 0.7 1.3 -0.2 -1.1
Alzheimer’s Disease (including proxy) 0.4 0.6 1.2 0.2 -1.1
Crohns Disease (2017) 0.3 0.6 0.7 -0.8 -0.8
Irritable Bowel Disease (IBD) 0.2 0.4 0.7 0.8 -0.3
Ulcerative Colitis (UC) 0.8 1.5 2.9 1.7 -0.2
Major Depression (MDD) 0.2 0.2 0.3 0.3 -0.6
Reaction Time 0.2 0.4 0.7 -0.2 -0.8
Verbal and Numeric Reasoning (VNR) 0.8 2.0 3.7 1.9 0.5
Breast Cancer 0.4 0.9 1.4 0.6 1.2
Ovarian Cancer 1.3 1.8 3.2 1.8 0.5
Prostate Cancer 0.0 0.0 0.1 0.3 -0.1
Age at First Birth 0.2 0.2 0.4 0.2 0.6
Bipolar Disorder (2011) 0.4 0.4 0.7 -0.9 0.0
Body Mass Index (BMI) (2010) 0.5 0.6 1.0 1.0 0.5
Coronary Artery Disease (CAD) 4.6 5.5 10.9 3.3 0.0
Crohns Disease (2012) 0.8 1.3 1.4 1.1 -1.2
Mean Putamen Volume 1.0 1.2 2.2 1.5 0.4
Fasting Glucose 0.7 0.8 1.4 1.2 -0.6
HbA1C 0.5 0.5 1.0 -0.1 1.0
HDL Cholesterol 0.4 0.7 0.8 -0.8 0.9
LDL Cholesterol 1.1 1.7 2.8 -1.7 0.8
Lupus 0.1 0.2 0.4 -0.1 -0.6
Neuroticism (2016) 0.1 0.1 0.3 -0.1 -0.5
Primary Biliary Cirrhosis 4.8 6.9 8.3 2.3 2.9
Rheumatoid Arthritis 5.6 7.7 10.0 2.3 3.2
Schizophrenia (2014) 1.0 2.2 3.6 0.8 -1.9
Triglycerides 0.9 1.4 2.0 1.4 0.9
Type 2 Diabetes (T2D) (2012) 1.4 1.6 3.2 -1.8 -0.0
Ulcerative Colitis 3.9 5.7 10.9 3.3 -0.7
Blood Eosinophil Count 2.0 15.2 30.5 0.1 -5.5
Blood Platelet Count 0.1 1.1 1.4 -0.9 -1.2
Blood Red Count 0.3 3.1 4.0 -2.0 1.5
Blood White Count 0.3 1.9 2.9 1.7 -1.0
Heel T-Score 0.1 0.4 0.7 0.4 0.8
BMI 0.4 2.5 3.5 1.2 1.9
Height 0.1 1.0 1.7 1.3 0.6
Waist Hip Ratio (WHR) 0.6 2.6 5.2 -2.3 -0.1
Systolic Blood Pressure 0.0 0.2 0.3 -0.3 -0.5
Smoking Status 0.2 0.4 0.4 -0.6 -0.7
Allergy or Eczema 6.4 17.0 33.8 0.4 -5.8
Cardiovascular Disease 0.2 0.6 1.1 0.2 1.0
Hypothyroidism (self reported) 3.2 7.3 7.3 2.7 2.7
Respiratory disease 7.1 15.9 30.5 -1.1 -5.5
Type 2 Diabetes (T2D) (2018) 0.2 0.4 0.6 0.5 0.8
Lung FEV1/FVC ratio 1.8 8.9 17.6 -0.4 4.2
Lung FVC 0.2 1.1 2.3 0.0 1.5
Neuroticism 0.1 0.2 0.4 -0.1 -0.6
Chronotype (morning person) 2.0 4.7 5.1 -2.3 -2.1
Hair Pigment 0.0 0.4 0.5 0.4 0.7
Tanning 0.0 0.2 0.4 -0.6 0.1
Hand grip strength (left) 0.3 0.9 1.8 -1.3 -0.1
Number of treatments/medications taken 1.1 2.0 3.4 1.9 0.8
Average weekly spirits intake 1.1 1.4 1.6 -1.1 -1.3
Sensitivity / hurt feelings 1.6 2.7 5.3 -0.3 -2.3
Frequency of depressed mood in last 2 weeks 0.1 0.2 0.2 -0.4 -0.5
Hearing difficulty/problems: Yes 0.6 1.0 1.9 1.4 0.2
Relative age of first facial hair 1.1 2.2 2.5 -1.4 -1.6
Other serious medical condition/disability diagnosed by doctor 1.7 2.2 4.0 2.0 0.7
Ever used hormone-replacement therapy (HRT) 1.1 1.3 1.6 1.0 1.3
Ever had hysterectomy (womb removed) 0.2 0.2 0.3 0.4 0.5
Systolic blood pressure, automated reading 0.2 0.6 0.7 -0.8 -0.8
Eye problems/disorders: Diabetes related eye disease 0.0 0.0 0.0 -0.0 0.2
Angina 2.1 2.8 5.6 -0.0 2.4
Medication for hormone replacement therapy 0.1 0.1 0.1 -0.3 0.3
Vitamin and mineral supplements 2.4 3.3 3.5 -1.8 1.9
Supplements: Zinc 0.1 0.1 0.1 0.2 0.3
Medication: Co-codamol 0.6 0.7 1.2 1.1 -0.4
Medication: Metformin 0.4 0.5 0.5 0.7 0.7
Diabetes (father) 0.3 0.4 0.5 -0.6 0.7
Diabetes (mother) 0.6 0.7 1.2 -0.5 1.1
Severe depression (siblings) 1.2 1.3 2.4 0.4 1.6
Pack years adult smoking proportion 1.5 2.3 2.7 -1.4 1.6
Impedance of leg (right) 0.4 1.9 2.3 -1.5 -1.3
Leg fat-free mass (left) 0.4 2.1 4.2 -0.1 2.0
Trunk fat percentage 0.5 2.1 4.0 0.5 2.0
Hand grip strength (right) 1.2 3.1 6.0 -2.5 -0.5
Townsend deprivation index at recruitment 0.3 0.4 0.7 0.8 0.3
Current tobacco smoking 1.0 1.7 2.6 -1.6 0.9
Average weekly fortified wine intake 0.7 0.8 1.5 0.5 -1.2
Maternal smoking around birth 0.9 1.3 2.6 1.6 -0.2
Fed-up feelings 0.1 0.2 0.2 -0.5 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.2 -0.5 -0.2
Relative age voice broke 0.0 0.0 0.0 -0.0 0.0
Taking other prescription medications 1.9 2.9 5.7 2.4 -0.2
Age when periods started (menarche) 1.1 2.6 5.1 -2.3 0.3
Bilateral oophorectomy (both ovaries removed) 2.6 3.0 3.3 1.6 1.8
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.8 2.2 -1.1 1.5
Tinnitus: Yes, but not now, but have in the past 1.8 1.9 3.6 -1.9 -0.4
Qualifications: CSEs or equivalent 2.8 3.7 7.3 -2.7 -0.2
Serious illness, injury or assault to yourself 0.6 0.7 1.2 -1.1 -0.4
High blood pressure 0.3 0.9 1.5 0.5 1.2
Hayfever, allergic rhinitis or eczema 5.9 12.8 25.6 0.0 -5.1
Multivitamins +/- minerals 1.7 2.2 4.2 2.0 -0.5
Stomach or abdominal pain in last month 0.0 0.0 0.0 0.2 0.2
Supplements: Glucosamine 0.6 0.8 0.9 0.8 -1.0
Diverticular disease/diverticulitis (self-reported) 0.5 0.5 0.6 -0.7 0.7
Medication: Atenolol 6.3 7.9 9.8 3.1 2.4
Medication: Levothyroxine sodium 2.9 4.9 5.7 2.4 2.0
Sitting height 0.0 0.1 0.2 -0.4 0.1
Chronic bronchitis/emphysema (father) 0.1 0.1 0.2 -0.5 0.2
High blood pressure (mother) 0.8 1.1 1.6 -0.7 1.3
Body mass index (BMI) 0.6 2.7 5.3 0.2 2.3
Impedance of leg (left) 0.4 2.0 2.8 -1.1 -1.7
Leg predicted mass (left) 0.4 2.1 4.2 -0.0 2.1
Trunk fat mass 0.5 2.3 4.4 0.5 2.1
Waist circumference 0.6 2.1 4.1 -0.2 2.0
Number of incorrect matches in round 1.0 1.7 2.4 1.0 -1.6
Past tobacco smoking 1.2 2.2 3.9 -0.8 2.0
Alcohol usually taken with meals 0.0 0.1 0.1 0.3 -0.2
Nervous feelings 1.7 3.2 4.9 -1.2 -2.2
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 0.9 -1.0 0.3
Hearing difficulty/problems with background noise 0.8 1.3 2.3 1.5 0.4
Hair/balding pattern: Pattern 2 0.9 1.1 2.1 0.3 1.4
Had menopause 1.7 2.1 3.5 0.9 1.9
Had other major operations 0.1 0.1 0.3 0.1 0.5
Forced vital capacity (FVC) 0.2 0.9 1.8 -1.3 -0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.9 2.5 -1.6 1.1
Ever unenthusiastic/disinterested for a whole week 1.5 1.8 3.1 -0.8 -1.8
Qualifications: None of the above 0.3 0.5 0.9 0.9 -0.5
Financial difficulties in last 2 years 0.2 0.3 0.4 0.4 0.7
Mouth/teeth dental problems 0.5 0.7 1.2 -0.4 -1.1
Heart attack 5.0 6.4 9.5 1.8 3.1
Allergy 6.6 15.2 30.2 0.4 5.5
Pain all over the body in last month 2.3 2.5 4.5 2.1 0.7
Diabetes (self-reported) 1.3 2.0 2.3 1.3 1.5
Hayfever/allergic rhinitis (self-reported) 3.8 5.1 10.0 -0.3 -3.2
Medication: Ramipril 2.0 2.6 4.8 2.2 0.7
Medication: Simvastatin 0.6 0.9 1.5 0.6 1.2
Fluid intelligence score 1.2 2.5 4.6 2.1 0.6
Illnesses of siblings 0.4 0.6 0.6 -0.8 -0.8
Neuroticism score 1.2 2.4 4.1 -0.9 -2.0
Weight 0.5 2.6 5.2 -0.1 2.3
Impedance of arm (right) 0.2 0.9 1.8 -0.3 -1.3
Arm fat percentage (right) 0.4 1.6 2.9 0.5 1.7
Trunk fat-free mass 0.1 0.7 1.3 -0.5 1.1
Hip circumference 0.7 2.9 5.4 0.6 2.3
Time employed in main current job 0.5 0.6 0.8 0.6 0.9
Alcohol intake versus 10 years previously 0.3 0.5 0.8 -0.4 0.9
Father’s age at death 0.0 0.0 0.0 0.1 -0.0
Worrier / anxious feelings 0.6 1.2 2.2 -0.4 -1.5
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 0.7 0.9 -0.0
Falls in the last year 0.1 0.2 0.3 -0.2 -0.6
Hair/balding pattern: Pattern 3 0.3 0.5 0.8 -0.4 -0.9
Number of live births 0.3 0.5 0.6 -0.5 0.8
Forced expiratory volume in 1-second (FEV1) 0.6 1.9 3.1 -1.8 0.9
Pulse rate 1.5 2.6 5.1 0.3 -2.3
Happiness 0.7 0.8 1.7 0.1 -1.3
Noisy workplace 2.2 2.7 4.1 1.1 2.0
Qualifications: A levels/AS levels or equivalent 4.4 9.7 12.6 3.6 2.6
Serious illness, injury or assault of a close relative in last 2 years 3.5 4.0 5.5 -1.6 -2.3
Mouth/teeth dental problems: Dentures 1.2 2.0 4.1 -0.1 2.0
Asthma 4.9 9.7 19.1 -0.5 -4.4
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 1.9 -0.3 -1.4
Medication: Cholesterol lowering 1.4 2.2 2.7 1.3 1.6
Depression (self-reported) 0.9 1.1 1.7 -0.7 -1.3
Medication: Lansoprazole 1.2 1.4 1.8 -1.4 1.0
Prospective memory result 1.4 1.7 2.0 -1.2 -1.4
Lung cancer (father) 0.8 0.9 1.0 -0.9 1.0
Illnesses of mother 1.7 2.1 4.2 -0.2 -2.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.7 1.7 -1.3 1.3
Pulse wave Arterial Stiffness index 1.5 1.8 3.3 1.8 0.5
Impedance of arm (left) 0.3 1.3 2.4 -0.4 -1.5
Arm fat mass (right) 0.6 2.6 5.1 0.4 2.2
Trunk predicted mass 0.1 0.7 1.3 -0.4 1.1
Standing height 0.0 0.3 0.5 -0.7 0.1
Length of working week for main job 0.0 0.0 0.0 0.1 -0.1
Exposure to tobacco smoke at home 0.5 0.5 0.6 -0.6 0.8
Breastfed as a baby 0.2 0.2 0.4 -0.6 -0.3
Tense / ‘highly strung’ 0.8 1.3 1.5 -1.1 -1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 2.2 3.3 5.4 -1.1 -2.3
Hair/balding pattern: Pattern 4 0.8 2.0 2.9 1.1 1.7
Birth weight of first child 2.1 3.7 6.5 -2.6 -1.0
Peak expiratory flow (PEF) 0.6 1.5 1.9 -1.4 -1.0
Pulse wave reflection index 2.5 3.1 5.5 2.3 0.9
Ever highly irritable/argumentative for 2 days 3.0 3.7 4.0 -1.8 -2.0
Loud music exposure frequency 0.8 0.8 1.2 -1.1 -0.7
Qualifications: O levels/GCSEs or equivalent 0.8 1.2 2.0 0.7 1.4
Mouth/teeth dental problems: Bleeding gums 1.1 1.4 2.9 -0.0 -1.7
Blood clot in the leg (DVT) 0.1 0.2 0.2 0.4 0.5
Medication: Paracetamol 1.0 1.6 2.6 1.6 0.8
Headache pain in last month 0.0 0.1 0.1 -0.3 -0.2
Medication for cholesterol, blood pressure or diabetes 0.6 0.9 0.9 -0.9 -1.0
Glaucoma (self-reported) 1.6 1.9 3.2 -0.8 1.8
Gout (self-reported) 0.1 0.2 0.2 0.4 0.4
Hypothyroidism/myxoedema (self-reported) 3.5 6.9 7.1 2.6 2.7
Medication: Amlodipine 0.4 0.6 1.2 -0.3 1.1
Medication: Ventolin 100micrograms inhaler 5.4 7.0 13.8 -0.3 -3.7
Birth weight 0.1 0.3 0.6 -0.1 0.7
Chronic bronchitis/emphysema (mother) 0.1 0.2 0.3 -0.2 -0.5
High blood pressure (siblings) 0.1 0.2 0.3 0.1 0.6
Forced vital capacity (FVC), Best measure 0.2 0.9 1.7 -1.3 0.4
Body fat percentage 0.4 1.6 3.1 0.4 1.8
Leg fat percentage (right) 0.5 1.6 3.2 -0.3 1.8
Arm fat-free mass (right) 0.2 1.3 2.3 -0.4 1.5
Exposure to tobacco smoke outside home 0.7 0.9 1.8 1.3 0.3
Comparative body size at age 10 0.4 1.2 1.6 0.8 1.3
Number of full brothers 0.4 0.5 0.8 -0.3 0.9
Worry too long after embarrassment 2.2 3.7 7.1 -0.6 -2.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.1 2.2 -1.5 -0.2
Wheeze or whistling in the chest in last year 0.7 1.2 2.4 -0.1 -1.6
Number of children fathered 1.0 1.1 1.7 0.7 1.3
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.2 1.1 -0.1
Age at first live birth 0.2 0.4 0.8 0.9 0.0
Pulse wave peak to peak time 1.7 1.9 3.6 -1.9 -0.6
Health satisfaction 0.8 1.0 1.7 0.6 -1.3
Shortness of breath walking on level ground 0.3 0.3 0.6 -0.8 -0.1
Qualifications: College or University degree 2.1 6.5 12.5 3.5 0.7
Eye problems/disorders: None of the above 0.5 0.6 0.6 0.7 -0.8
Mouth/teeth dental problems: Loose teeth 1.0 1.1 2.1 -0.4 1.5
Emphysema/chronic bronchitis 0.7 0.8 0.9 -0.8 -1.0
Medication for pain relief, constipation, heartburn 2.1 3.7 6.8 -2.6 -0.7
Neck or shoulder pain in last month 0.2 0.3 0.4 0.4 0.7
Medication: Blood pressure 0.6 1.1 1.6 0.7 1.3
Angina (self-reported) 2.5 3.3 6.7 -0.1 2.6
Migraine (self-reported) 0.6 0.8 1.5 0.2 1.2
Medication: Ibuprofen 0.2 0.3 0.5 -0.2 -0.7
Medication: Allopurinol 0.9 1.2 1.7 0.8 1.3
Medication: Omeprazole 2.0 2.4 4.7 0.1 -2.2
Medication: Seretide 50 evohaler 2.2 2.5 4.2 -0.9 -2.1
Mean time to correctly identify matches 0.3 0.6 0.9 0.6 -0.9
Heart disease (mother) 0.2 0.2 0.4 0.2 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 0.7 0.8 -0.1
Whole body fat mass 0.5 2.1 4.1 0.4 2.0
Leg fat mass (right) 0.6 2.2 4.3 -0.2 2.1
Arm predicted mass (right) 0.3 1.8 3.3 -0.5 1.8
Pulse rate, automated reading 1.4 4.5 8.5 -0.7 -2.9
Alcohol intake frequency. 0.2 0.5 1.0 -1.0 0.3
Comparative height size at age 10 0.1 0.3 0.7 -0.8 0.0
Number of full sisters 0.3 0.4 0.6 0.8 0.4
Suffer from ‘nerves’ 2.1 3.3 4.2 -2.0 -1.5
Overall health rating 1.0 2.2 4.4 2.1 0.1
Chest pain or discomfort 0.1 0.1 0.2 0.1 -0.5
Had major operations 0.8 1.0 2.0 1.4 0.1
Age at last live birth 0.5 0.7 0.7 0.8 -0.8
Family relationship satisfaction 1.0 1.3 1.9 -0.8 -1.4
Leg pain on walking 0.3 0.4 0.8 -0.9 -0.1
Qualifications: NVQ or HND or HNC or equivalent 0.8 0.9 1.7 -1.3 0.5
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.3 0.5 0.3
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 0.7 0.8 -0.0
Medication: Aspirin 3.3 4.4 5.5 2.3 1.8
Supplements: Vitamin C 1.7 2.0 3.9 -0.4 -2.0
Knee pain experienced in last month 0.8 1.2 2.3 -0.2 1.5
Hypertension (Self-reported) 0.3 0.7 1.1 0.6 1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.0 0.0 0.0 0.2 -0.1
Illnesses of father: Heart disease 2.7 3.8 6.4 2.5 1.1
Illnesses of siblings: Diabetes 1.2 1.4 2.8 0.3 1.7
Smoking status: Previous 2.2 3.3 6.6 0.3 -2.6
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.3 1.8 -0.9 -1.3
Whole body fat-free mass 0.2 1.3 2.4 -0.3 1.6
Leg fat-free mass (right) 0.3 1.4 2.8 -0.0 1.7
Arm fat percentage (left) 0.3 1.3 2.4 0.4 1.6
Average weekly red wine intake 1.4 2.0 3.8 1.9 -0.5
Handedness (chirality/laterality): Left-handed 1.6 2.0 2.5 1.2 1.6
Mood swings 0.7 1.3 2.0 -1.4 0.7
Loneliness, isolation 0.2 0.2 0.4 -0.7 -0.2
Long-standing illness, disability or infirmity 1.2 1.8 2.3 1.5 -1.1
Ever had bowel cancer screening 2.2 2.6 4.9 2.2 -0.4
Diabetes diagnosed by doctor 1.5 2.4 2.8 1.7 1.4
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.0 0.1 1.0
Friendships satisfaction 0.4 0.5 0.7 -0.8 -0.6
Qualifications: nursing, teaching 0.9 1.4 1.4 1.2 1.2
Commuting to job workplace: Walk 1.1 1.2 2.0 -1.4 0.6
Eye problems/disorders: Cataract 2.1 2.4 4.6 -2.1 -0.5
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.5 -0.4 -0.7
Medication for cholesterol 0.7 1.0 2.0 -0.2 -1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.2 1.1 0.4
Back pain experienced in last month 0.3 0.5 0.9 -0.0 1.0
Mineral and other dietary supplements 1.2 1.6 2.1 1.0 1.5
Breast cancer (self-reported) 0.3 0.3 0.5 -0.7 0.4
Asthma (self-reported) 5.1 10.1 19.7 -0.7 -4.4
Osteoporosis (self-reported) 2.3 2.8 4.2 -1.2 -2.0
Osteoarthritis (self-reported) 0.4 0.5 0.9 0.9 0.4
Medication: Aspirin 2.2 2.9 4.6 2.1 1.1
Medication: Gliclazide 0.8 0.9 1.8 1.3 -0.2
Illnesses of father: None of the above (group 1) 0.6 0.7 1.2 -1.1 -0.4
Smoking status: Current 1.0 1.6 2.2 -1.5 1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 1.5 -0.2 1.2
Whole body water mass 0.2 1.3 2.4 -0.3 1.6
Leg predicted mass (right) 0.3 1.5 3.0 0.0 1.7
Arm fat mass (left) 0.6 2.4 4.8 0.2 2.2
Number of self-reported non-cancer illnesses 1.0 1.7 3.5 1.9 -0.0
Average weekly champagne plus white wine intake 1.1 1.5 2.4 1.5 0.8
Miserableness 0.2 0.3 0.4 -0.6 -0.5
Guilty feelings 2.1 3.1 3.3 -1.7 -1.8
Wears glasses or contact lenses 0.3 0.3 0.4 -0.5 -0.6
Ever taken oral contraceptive pill 0.9 1.0 1.2 -0.9 -1.1
Hearing aid user 0.1 0.1 0.1 -0.4 -0.4
Mother’s age at death 2.6 3.2 6.1 2.5 0.6
Financial situation satisfaction 0.0 0.0 0.1 -0.1 0.3
Tinnitus: Yes, now most or all of the time 1.1 1.3 1.4 -1.2 -1.1
Commuting to job workplace: Public transport 0.5 0.6 1.1 -1.1 0.0
Eye problems/disorders: Glaucoma 3.1 3.7 6.3 -1.0 2.5
Medication: Blood pressure 0.2 0.3 0.3 0.6 0.5
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.3 -0.6 0.4
Supplements: Fish oil (including cod liver oil) 1.3 1.7 2.7 -0.9 -1.6
High cholesterol (Self-reported) 0.4 0.7 1.4 1.2 0.0
Medication: Bendroflumethiazide 0.1 0.2 0.2 0.5 0.3
Medication: Paracetamol 1.1 1.7 2.0 1.1 1.4
Medication: Lisinopril 1.0 1.3 2.0 -0.8 1.4
Medication: Atorvastatin 2.9 3.6 5.3 1.4 2.3
Illnesses of father: High blood pressure 0.1 0.1 0.1 -0.4 0.4
Alcohol drinker status: Never 0.4 0.5 1.0 -1.0 -0.1
Ever smoked 1.4 2.4 2.8 1.4 -1.7
Basal metabolic rate 0.3 1.5 2.8 -0.2 1.7
Leg fat percentage (left) 0.3 1.0 2.0 -0.1 1.4
Arm fat-free mass (left) 0.3 1.6 3.2 -0.1 1.8
Number of operations (self-reported) 0.4 0.6 0.8 0.7 0.9
Average weekly beer plus cider intake 0.6 0.9 1.0 -0.9 1.0
Irritability 0.1 0.1 0.2 -0.1 -0.5
Risk taking 0.2 0.3 0.5 -0.4 -0.7
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.2 0.4 -0.2
Fractured/broken bones in last 5 years 0.9 1.1 1.3 -1.0 1.1
Age started oral contraceptive pill 1.5 1.9 3.5 1.9 0.5
Diastolic blood pressure, automated reading 1.3 3.9 4.1 -2.0 -1.9
Ever depressed for a whole week 0.8 1.0 1.6 -0.7 -1.3
Unable to work because of sickness or disability 0.1 0.2 0.2 0.5 0.3
Commuting to job workplace: Cycle 0.0 0.1 0.1 -0.2 0.2
Myopia 2.0 2.8 5.5 2.4 -0.4
Vascular/heart problems diagnosed by doctor 1.0 2.8 5.0 -0.8 -2.2
Cholesterol lowering medication 1.0 1.5 1.6 1.2 1.2
Medication: Omeprazole (e.g. Zanprol) 1.1 1.3 2.7 0.1 -1.6
Pain experienced in last month 0.6 1.1 2.0 -0.4 -1.4
Supplements: Calcium 0.6 0.7 1.0 -1.0 -0.6
Basal cell carcinoma (self-reported) 0.2 0.2 0.2 0.4 0.5
Heart attack/myocardial infarction (self-reported) 5.4 6.9 10.4 1.9 3.2
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.3 0.4 0.6
Heart disease (siblings) 0.7 0.9 1.7 -0.2 1.3
Alcohol drinker status: Previous 0.3 0.4 0.7 -0.8 -0.3
Pack years of smoking 1.0 1.4 2.0 -0.9 1.4
Impedance of whole body 0.4 1.9 2.9 -0.9 -1.7
Leg fat mass (left) 0.5 1.9 3.7 -0.0 1.9
Arm predicted mass (left) 0.2 1.2 2.4 -0.1 1.6