Hub : Traits :

Respiratory disease

617 significantly associated models · 169 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 7686056 11137778 5 3 8.6e-12 2.0e-11 2.5e-01 97 ENO1 KIF1B RERE
2 1 151055670 153015059 5 4 5.4e-13 2.1e-14 8.8e-01 100 FLG LINGO4 S100A11 TDRKH
3 1 153504759 154889485 1 1 2.4e-08 9.8e-08 1.3e-03 64 C1orf43
4 1 166702558 168182443 1 1 2.2e-17 2.0e-17 1.0e+00 100 CD247
5 1 172311679 173713130 1 1 2.5e-07 3.6e-08 2.8e-09 -16 TNFSF18
6 1 202317696 203743653 1 1 2.9e-07 1.2e-09 6.9e-05 57 PPFIA4
7 2 101994731 104027106 5 4 1.7e-32 8.3e-60 7.1e-12 82 IL18R1 IL1R1 SLC9A2
8 2 202952678 204788156 3 1 5.4e-09 1.0e-07 3.6e-01 97 CARF
9 2 241941773 243048760 9 2 5.3e-29 8.2e-28 4.9e-01 100 AC093642.3 D2HGDH
10 3 32339493 33825021 1 1 2.5e-08 9.1e-16 1.7e-09 44 GLB1
11 3 127097277 128821807 2 2 2.7e-08 3.9e-09 1.0e+00 100 EEFSEC RUVBL1
12 3 195734915 197083723 1 1 5.1e-08 2.5e-09 3.0e-04 63 NRROS
13 4 38097478 39643536 3 1 8.2e-16 2.8e-17 1.4e-03 86 TLR1
14 4 122377715 124935698 2 4 1.8e-16 2.9e-17 1.0e+00 100 KIAA1109 SPATA5
15 5 109381583 111527482 4 5 5.4e-18 4.0e-40 4.4e-07 86 CAMK4 SLC25A46 TSLP WDR36
16 5 130588008 132900729 16 8 1.1e-25 8.7e-30 NaN NaN AC034220.3 KIF3A P4HA2-AS1 SLC22A5
17 5 139232299 140784895 3 1 2.3e-07 5.4e-07 3.8e-01 97 SRA1
18 5 140789933 142230251 1 1 3.2e-13 6.3e-14 4.0e-03 85 NDFIP1
19 5 156131251 157697754 1 1 1.5e-09 6.1e-08 5.4e-01 99 ADAM19
20 6 34528785 35987507 2 1 4.9e-10 2.7e-10 6.7e-02 92 ZNF76
21 6 63596112 64978456 1 1 1.9e-07 1.0e-08 1.3e-02 81 RP5-1148A21.3
22 6 89941356 91704536 1 2 8.3e-19 7.5e-26 1.2e-05 83 BACH2
23 6 134905567 136516257 2 2 8.1e-10 4.1e-08 6.5e-01 99 AHI1
24 7 27171588 28918565 1 2 1.1e-10 2.3e-17 3.8e-07 64 JAZF1
25 10 5238196 7317647 2 2 3.4e-08 2.5e-09 1.0e+00 100 FBXO18 PRKCQ
26 10 74879374 76266883 1 1 1.2e-07 8.2e-07 6.4e-03 70 RP11-574K11.5
27 10 93657148 95151622 3 1 1.7e-11 2.8e-12 8.9e-03 86 HHEX
28 11 60549966 62346131 7 1 7.5e-14 1.4e-13 2.1e-01 97 FADS3
29 11 64645119 66035608 1 1 1.9e-07 5.1e-09 4.0e-06 38 FAM89B
30 11 75369353 77069746 2 2 1.9e-27 1.1e-48 3.6e-18 65 LRRC32 PRKRIR
31 12 55601472 58677299 9 4 2.4e-18 1.3e-26 1.3e-10 64 KIF5A RPS26 STAT6
32 12 70713655 72104017 1 1 4.8e-09 3.5e-09 1.0e+00 100 CTD-2021H9.1
33 13 99047988 100728229 2 1 6.3e-13 2.1e-19 5.6e-10 53 DOCK9-AS2
34 15 40884719 42468786 2 1 1.4e-07 4.2e-08 5.2e-03 74 OIP5-AS1
35 15 66662107 68789191 4 3 4.1e-30 5.5e-47 1.1e-15 69 IQCH SMAD3
36 16 10325245 12138068 6 10 3.8e-19 2.3e-27 NaN NaN CLEC16A DEXI RMI2 RP11-396B14.2 RP11-876N24.4 RP11-876N24.5
37 16 26526350 28065536 3 1 6.1e-18 5.1e-16 1.9e-06 66 IL4R
38 16 88241380 89617518 1 1 2.8e-07 2.8e-07 3.1e-05 34 TRAPPC2L
39 17 29800656 31275580 1 1 6.8e-08 6.3e-05 6.6e-01 99 RHOT1
40 17 36410559 39502398 24 9 1.0e-60 2.1e-58 NaN NaN GSDMA GSDMB KRT222 MED24 MSL1 PCGF2 PGAP3 THRA
41 17 42413481 43570226 3 2 1.0e-08 1.8e-08 3.7e-02 86 CTD-2020K17.3 DCAKD
42 17 46888301 48347817 1 1 3.9e-08 9.9e-15 4.4e-10 35 RP5-1029K10.2
43 17 61805401 63197920 1 1 2.8e-08 8.1e-08 1.0e+00 100 DDX5
44 19 45585167 46994833 2 1 1.0e-08 3.4e-09 1.0e+00 100 DMWD
45 20 61576647 62912463 2 1 1.0e-08 3.3e-08 6.9e-02 89 STMN3
46 21 39849553 41254456 1 1 2.3e-07 1.7e-07 1.0e+00 100 PSMG1
47 22 41071659 42917154 11 1 8.6e-10 7.2e-10 1.0e+00 100 POLR3H

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (in father) 1.06 1 0 0.0 0.00 1.0e+00 CARF
Alzheimer’s Disease (including proxy) 1.09 1 0 0.0 0.00 1.0e+00 CARF
Crohns Disease (2017) 5.79 17 11 33.3 0.31 1.6e-01 AC034220.3 BACH2 FADS3 GSDMA GSDMB HHEX KIAA1109 KIF3A LRRC32 MED24 NDFIP1 P4HA2-AS1 PGAP3 RP11-574K11.5 SLC22A5 SMAD3 STMN3
Irritable Bowel Disease (IBD) 5.13 18 13 39.4 0.19 3.7e-01 AC034220.3 BACH2 GSDMA GSDMB HHEX KIAA1109 KIF3A LRRC32 MED24 NDFIP1 P4HA2-AS1 PGAP3 PRKRIR RMI2 RP11-574K11.5 SLC22A5 SMAD3 STMN3
Ulcerative Colitis (UC) 2.71 10 3 9.1 0.13 7.1e-01 GSDMA GSDMB KIAA1109 LRRC32 MED24 P4HA2-AS1 PGAP3 PRKRIR SMAD3 STMN3
Major Depression (MDD) 1.11 1 0 0.0 0.00 1.0e+00 C1orf43
Verbal and Numeric Reasoning (VNR) 1.06 2 1 3.0 0.00 1.0e+00 FADS3 RPS26
Breast Cancer 1.49 5 3 9.1 0.71 1.2e-01 AC034220.3 KIF1B P4HA2-AS1 SLC22A5 TLR1
Prostate Cancer 2.08 3 3 9.1 0.00 1.0e+00 EEFSEC RUVBL1 STMN3
Body Mass Index (BMI) (2010) 1.21 1 0 0.0 0.00 1.0e+00 SMAD3
Coronary Artery Disease (CAD) 1.38 1 1 3.0 0.00 1.0e+00 CARF
Crohns Disease (2012) 4.35 9 6 18.2 -0.37 2.3e-01 AC034220.3 FADS3 LRRC32 NDFIP1 P4HA2-AS1 PGAP3 SLC22A5 SMAD3 STMN3
Fasting Glucose 1.34 1 1 3.0 0.00 1.0e+00 FADS3
HDL Cholesterol 2.43 4 4 12.1 -0.69 2.0e-01 FADS3 GSDMB KIF5A PGAP3
LDL Cholesterol 1.46 1 1 3.0 0.00 1.0e+00 FADS3
Lupus 2.31 4 0 0.0 -0.66 1.1e-01 DEXI GSDMB RP11-876N24.5 ZNF76
Primary Biliary Cirrhosis 2.66 4 2 6.1 -0.41 5.0e-01 DEXI GSDMB PGAP3 RMI2
Rheumatoid Arthritis 1.72 4 0 0.0 0.97 3.0e-02 GSDMB NRROS PCGF2 PGAP3
Schizophrenia 1.13 1 0 0.0 0.00 1.0e+00 RERE
Triglycerides 1.89 2 2 6.1 0.00 1.0e+00 FADS3 KIF5A
Type 2 Diabetes (T2D) 1.62 1 1 3.0 0.00 1.0e+00 HHEX
Ulcerative Colitis 2.45 4 1 3.0 0.29 7.1e-01 GSDMB OIP5-AS1 PGAP3 STMN3
Blood Eosinophil Count 19.51 51 46 139.4 0.87 1.3e-21 AC034220.3 AC093642.3 AHI1 BACH2 CAMK4 CARF CD247 CLEC16A D2HGDH DCAKD DEXI DMWD DOCK9-AS2 FADS3 FBXO18 GSDMA GSDMB HHEX IL18R1 IL1R1 IL4R IQCH KIAA1109 KIF1B KIF3A KRT222 LRRC32 MED24 NDFIP1 NRROS OIP5-AS1 P4HA2-AS1 POLR3H PRKCQ PRKRIR RERE RMI2 RP11-396B14.2 RP11-876N24.4 RP11-876N24.5 RP5-1029K10.2 RPS26 SLC22A5 SLC25A46 SLC9A2 SMAD3 SPATA5 STAT6 THRA TSLP WDR36
Blood Platelet Count 2.59 26 23 69.7 0.37 4.0e-02 AC034220.3 C1orf43 CARF DCAKD DMWD EEFSEC ENO1 FADS3 GSDMB KIAA1109 KIF1B KIF3A KIF5A NDFIP1 P4HA2-AS1 PGAP3 POLR3H PSMG1 RERE RMI2 RP5-1029K10.2 RUVBL1 SLC22A5 STAT6 STMN3 TRAPPC2L
Blood Red Count 1.08 13 6 18.2 0.28 3.1e-01 AHI1 BACH2 DEXI FADS3 GSDMB HHEX KIF5A KRT222 NDFIP1 PCGF2 PGAP3 RPS26 STMN3
Blood White Count 11.97 26 18 54.5 0.72 3.8e-06 AC034220.3 AHI1 BACH2 CLEC16A DEXI ENO1 FADS3 GSDMA GSDMB JAZF1 KIF1B KIF3A MED24 MSL1 NDFIP1 OIP5-AS1 P4HA2-AS1 PGAP3 RP11-396B14.2 RP11-876N24.4 RP11-876N24.5 RP5-1029K10.2 SLC22A5 STMN3 THRA ZNF76
Heel T-Score 1.44 16 8 24.2 -0.13 6.3e-01 BACH2 CARF DCAKD DDX5 DMWD ENO1 FADS3 GLB1 IQCH JAZF1 KIF1B PCGF2 POLR3H RERE RPS26 ZNF76
BMI 0.93 12 3 9.1 -0.16 6.2e-01 CAMK4 CARF GSDMA IQCH MED24 PSMG1 RHOT1 RP5-1148A21.3 RPS26 RUVBL1 SMAD3 TLR1
Height 2.11 28 19 57.6 -0.40 1.7e-02 AC034220.3 AHI1 C1orf43 CARF DCAKD DDX5 DMWD FADS3 FAM89B GSDMA IQCH JAZF1 KIAA1109 KIF1B KIF3A MSL1 NDFIP1 OIP5-AS1 P4HA2-AS1 RERE RHOT1 RP5-1029K10.2 SLC22A5 SMAD3 STAT6 STMN3 THRA ZNF76
Waist Hip Ratio (WHR) 1.24 9 2 6.1 0.05 8.9e-01 DEXI DMWD GSDMA IQCH JAZF1 MED24 RP11-396B14.2 RP11-876N24.5 THRA
Systolic Blood Pressure 1.47 13 8 24.2 0.46 1.2e-01 CARF CTD-2020K17.3 DCAKD DDX5 DMWD ENO1 HHEX OIP5-AS1 RERE RP5-1029K10.2 RUVBL1 SMAD3 SRA1
Smoking Status 1.81 6 3 9.1 0.53 2.8e-01 IQCH PGAP3 POLR3H RERE RPS26 STMN3
Allergy or Eczema 21.07 57 50 151.5 0.92 1.5e-30 AC093642.3 AHI1 BACH2 C1orf43 CAMK4 CD247 CLEC16A D2HGDH DEXI ENO1 FBXO18 FLG GSDMA GSDMB IL18R1 IL1R1 IL4R IQCH JAZF1 KIAA1109 KIF3A KRT222 LINGO4 LRRC32 MED24 MSL1 NDFIP1 NRROS OIP5-AS1 P4HA2-AS1 PGAP3 POLR3H PRKCQ PRKRIR PSMG1 RERE RMI2 RP11-396B14.2 RP11-574K11.5 RP11-876N24.4 RP11-876N24.5 RP5-1029K10.2 RPS26 S100A11 SLC22A5 SLC25A46 SLC9A2 SMAD3 SPATA5 STAT6 STMN3 TDRKH THRA TLR1 TNFSF18 TSLP WDR36
Cardiovascular Disease 1.28 7 1 3.0 0.66 1.0e-01 DCAKD OIP5-AS1 P4HA2-AS1 RERE RP5-1029K10.2 RPS26 SLC22A5
Hypothyroidism (self reported) 3.14 9 6 18.2 -0.17 6.2e-01 AHI1 BACH2 CD247 FADS3 FBXO18 POLR3H RERE RPS26 TLR1
Type 2 Diabetes (T2D) 1.48 4 1 3.0 0.57 4.3e-01 C1orf43 HHEX JAZF1 PGAP3
Lung FEV1/FVC ratio 4.98 31 20 60.6 -0.72 1.2e-06 AC034220.3 ADAM19 BACH2 C1orf43 CARF D2HGDH DDX5 DEXI DMWD EEFSEC FAM89B GSDMB IL18R1 IQCH MED24 MSL1 P4HA2-AS1 PCGF2 PRKCQ RERE RP11-396B14.2 RP11-574K11.5 RP5-1029K10.2 RPS26 RUVBL1 SLC22A5 SLC9A2 SMAD3 STAT6 THRA ZNF76
Lung FVC 2.01 15 9 27.3 -0.06 8.1e-01 AC034220.3 AHI1 CARF CLEC16A GSDMB IQCH KIF1B LINGO4 P4HA2-AS1 PGAP3 RP11-574K11.5 RPS26 SLC22A5 SRA1 STMN3
Neuroticism 1.17 4 0 0.0 -0.66 3.4e-01 AHI1 IQCH POLR3H RERE
Chronotype (morning person) 1.18 1 0 0.0 0.00 1.0e+00 KIAA1109
Hair Pigment 0.19 12 8 24.2 -0.07 8.2e-01 AHI1 FADS3 JAZF1 KIF1B KIF5A MSL1 PCGF2 RERE RPS26 STMN3 TRAPPC2L ZNF76
Tanning 0.24 2 1 3.0 0.00 1.0e+00 JAZF1 TRAPPC2L
Hand grip strength (left) 2.20 5 4 12.1 0.98 2.1e-05 AC034220.3 KIF1B KIF3A P4HA2-AS1 SLC22A5
Number of treatments/medications taken 2.71 3 0 0.0 -1.00 7.1e-04 CLEC16A FADS3 P4HA2-AS1
Sensitivity / hurt feelings 1.04 1 0 0.0 0.00 1.0e+00 DCAKD
Relative age of first facial hair 1.10 2 0 0.0 0.00 1.0e+00 DCAKD PSMG1
Systolic blood pressure, automated reading 1.53 7 2 6.1 -0.97 3.5e-04 DCAKD DMWD ENO1 HHEX OIP5-AS1 RERE RP5-1029K10.2
Vitamin and mineral supplements 1.43 1 0 0.0 0.00 1.0e+00 STAT6
Medication: Metformin 1.41 2 0 0.0 0.00 1.0e+00 HHEX JAZF1
Impedance of leg (right) 1.09 5 4 12.1 -0.68 1.4e-01 DCAKD JAZF1 RP5-1029K10.2 RPS26 S100A11
Leg fat-free mass (left) 1.36 7 4 12.1 0.81 4.6e-03 AC034220.3 KIAA1109 MSL1 P4HA2-AS1 RPS26 SLC22A5 ZNF76
Trunk fat percentage 1.20 7 5 15.2 -0.99 6.7e-06 DCAKD FLG IQCH OIP5-AS1 POLR3H RERE SMAD3
Hand grip strength (right) 2.37 6 4 12.1 0.97 1.8e-06 AC034220.3 KIF1B KIF3A P4HA2-AS1 SLC22A5 STAT6
Current tobacco smoking 1.58 3 0 0.0 0.00 1.0e+00 CARF POLR3H STMN3
Maternal smoking around birth 1.14 1 0 0.0 0.00 1.0e+00 POLR3H
Taking other prescription medications 3.83 6 0 0.0 -0.95 9.3e-04 ADAM19 AHI1 D2HGDH DEXI GSDMA GSDMB
Age when periods started (menarche) 1.64 5 2 6.1 0.01 9.8e-01 DCAKD EEFSEC PCGF2 PSMG1 RPS26
Heel bone mineral density (BMD) T-score, automated (left) 1.17 3 1 3.0 0.00 1.0e+00 FADS3 GLB1 RERE
High blood pressure 1.71 10 2 6.1 -0.85 2.5e-04 AC034220.3 DCAKD HHEX OIP5-AS1 P4HA2-AS1 RERE RP5-1029K10.2 RPS26 RUVBL1 SLC22A5
Hayfever, allergic rhinitis or eczema 19.19 54 42 127.3 -0.93 3.8e-31 AC093642.3 AHI1 BACH2 C1orf43 CAMK4 CD247 CLEC16A D2HGDH DEXI ENO1 FBXO18 FLG GSDMA GSDMB IL18R1 IL1R1 IL4R JAZF1 KIAA1109 KIF3A KRT222 LINGO4 LRRC32 MED24 MSL1 NDFIP1 NRROS OIP5-AS1 P4HA2-AS1 PGAP3 POLR3H PRKCQ PRKRIR PSMG1 RERE RMI2 RP11-396B14.2 RP11-876N24.4 RP11-876N24.5 RP5-1029K10.2 RPS26 S100A11 SLC22A5 SLC25A46 SLC9A2 SMAD3 SPATA5 STAT6 STMN3 THRA TLR1 TNFSF18 TSLP WDR36
Medication: Levothyroxine sodium 2.71 5 3 9.1 -0.20 7.0e-01 AHI1 BACH2 FADS3 FBXO18 RPS26
Sitting height 1.53 10 6 18.2 0.47 6.5e-02 AC034220.3 DEXI DMWD FADS3 KIAA1109 MSL1 P4HA2-AS1 RP5-1029K10.2 SLC22A5 STAT6
Chronic bronchitis/emphysema (father) 1.73 1 0 0.0 0.00 1.0e+00 IQCH
Body mass index (BMI) 0.90 6 1 3.0 -0.18 7.3e-01 PSMG1 RERE RHOT1 RPS26 RUVBL1 SMAD3
Impedance of leg (left) 1.10 6 4 12.1 -0.73 6.3e-02 DCAKD JAZF1 RP5-1029K10.2 RPS26 S100A11 SLC22A5
Leg predicted mass (left) 1.36 8 4 12.1 0.74 9.2e-03 AC034220.3 KIAA1109 MSL1 P4HA2-AS1 RPS26 SLC22A5 SMAD3 ZNF76
Trunk fat mass 1.04 5 2 6.1 -0.99 1.0e-03 FLG IQCH POLR3H RERE SMAD3
Waist circumference 1.06 3 2 6.1 0.00 1.0e+00 IQCH RPS26 SMAD3
Past tobacco smoking 1.31 3 1 3.0 0.00 1.0e+00 IQCH PSMG1 RPS26
Had menopause 0.88 1 0 0.0 0.00 1.0e+00 DDX5
Forced vital capacity (FVC) 1.22 8 3 9.1 0.60 1.1e-01 AHI1 CARF DMWD IQCH LINGO4 RP11-574K11.5 STMN3 ZNF76
Heel bone mineral density (BMD) T-score, automated (right) 1.33 5 2 6.1 0.99 1.6e-03 ENO1 FADS3 GLB1 RERE ZNF76
Qualifications: None of the above 0.98 2 1 3.0 0.00 1.0e+00 RP5-1029K10.2 RPS26
Heart attack 1.42 2 0 0.0 0.00 1.0e+00 CARF KIF5A
Allergy 23.87 68 57 172.7 0.96 2.5e-48 AC034220.3 AC093642.3 AHI1 BACH2 C1orf43 CAMK4 CD247 CLEC16A CTD-2020K17.3 D2HGDH DCAKD DEXI DOCK9-AS2 EEFSEC ENO1 FADS3 FBXO18 FLG GLB1 GSDMA GSDMB HHEX IL18R1 IL1R1 IL4R IQCH JAZF1 KIAA1109 KIF1B KIF3A KIF5A KRT222 LINGO4 LRRC32 MED24 MSL1 NDFIP1 NRROS OIP5-AS1 P4HA2-AS1 PGAP3 POLR3H PRKCQ PRKRIR PSMG1 RERE RMI2 RP11-396B14.2 RP11-574K11.5 RP11-876N24.4 RP11-876N24.5 RP5-1029K10.2 RPS26 S100A11 SLC22A5 SLC25A46 SLC9A2 SMAD3 SPATA5 STAT6 STMN3 TDRKH THRA TLR1 TNFSF18 TSLP WDR36 ZNF76
Diabetes (self-reported) 1.39 2 1 3.0 0.00 1.0e+00 HHEX JAZF1
Hayfever/allergic rhinitis (self-reported) 9.17 22 12 36.4 -0.96 3.8e-16 AC093642.3 BACH2 CAMK4 CD247 CLEC16A D2HGDH DEXI GSDMB IL18R1 KIAA1109 LRRC32 RP11-396B14.2 RP11-876N24.5 RPS26 SLC25A46 SLC9A2 SMAD3 SPATA5 TLR1 TNFSF18 TSLP WDR36
Medication: Simvastatin 1.32 1 0 0.0 0.00 1.0e+00 DMWD
Fluid intelligence score 1.06 1 0 0.0 0.00 1.0e+00 RPS26
Neuroticism score 1.10 1 0 0.0 0.00 1.0e+00 IQCH
Weight 1.06 7 4 12.1 0.52 1.3e-01 AC034220.3 FLG IQCH P4HA2-AS1 RPS26 SLC22A5 SMAD3
Impedance of arm (right) 1.39 14 6 18.2 -0.70 5.5e-03 DCAKD EEFSEC GSDMA JAZF1 KIF1B LRRC32 MED24 NDFIP1 POLR3H RP5-1029K10.2 RPS26 RUVBL1 SMAD3 THRA
Arm fat percentage (right) 1.10 7 2 6.1 -1.00 2.3e-06 CARF DCAKD IQCH OIP5-AS1 POLR3H RERE SMAD3
Trunk fat-free mass 1.53 8 7 21.2 0.90 1.7e-04 AC034220.3 DCAKD MSL1 P4HA2-AS1 RPS26 SLC22A5 STAT6 ZNF76
Hip circumference 0.84 4 0 0.0 0.31 6.9e-01 GSDMA MED24 PSMG1 SMAD3
Father's age at death 1.94 2 0 0.0 0.00 1.0e+00 P4HA2-AS1 SLC22A5
Frequency of tiredness / lethargy in last 2 weeks 1.46 1 0 0.0 0.00 1.0e+00 RP11-574K11.5
Falls in the last year 0.94 1 0 0.0 0.00 1.0e+00 CARF
Hair/balding pattern: Pattern 3 1.16 2 0 0.0 0.00 1.0e+00 AC034220.3 DCAKD
Number of live births 1.11 1 1 3.0 0.00 1.0e+00 FADS3
Forced expiratory volume in 1-second (FEV1) 1.92 11 4 12.1 0.90 1.5e-04 ADAM19 AHI1 LINGO4 P4HA2-AS1 PGAP3 RP11-574K11.5 RPS26 RUVBL1 SLC22A5 STMN3 ZNF76
Pulse rate 1.25 1 1 3.0 0.00 1.0e+00 FADS3
Qualifications: A levels/AS levels or equivalent 0.94 1 0 0.0 0.00 1.0e+00 RPS26
Mouth/teeth dental problems: Dentures 1.03 1 0 0.0 0.00 1.0e+00 PGAP3
Asthma 23.72 76 54 163.6 -1.00 8.2e-94 AC034220.3 AC093642.3 ADAM19 AHI1 BACH2 C1orf43 CAMK4 CARF CD247 CLEC16A CTD-2020K17.3 CTD-2021H9.1 D2HGDH DCAKD DDX5 DEXI DMWD DOCK9-AS2 EEFSEC ENO1 FADS3 FAM89B FLG GSDMA GSDMB HHEX IL18R1 IL1R1 IL4R IQCH JAZF1 KIAA1109 KIF1B KIF3A KIF5A KRT222 LINGO4 LRRC32 MED24 MSL1 NDFIP1 NRROS OIP5-AS1 P4HA2-AS1 PCGF2 PGAP3 POLR3H PPFIA4 PRKCQ PRKRIR RERE RMI2 RP11-396B14.2 RP11-574K11.5 RP11-876N24.4 RP11-876N24.5 RP5-1029K10.2 RP5-1148A21.3 RPS26 RUVBL1 S100A11 SLC22A5 SLC25A46 SLC9A2 SMAD3 SRA1 STAT6 STMN3 TDRKH THRA TLR1 TNFSF18 TRAPPC2L TSLP WDR36 ZNF76
Medication: Ibuprofen (e.g. Nurofen) 1.38 1 1 3.0 0.00 1.0e+00 STAT6
Forced expiratory volume in 1-second (FEV1), Best measure 2.01 10 5 15.2 0.93 4.2e-05 ADAM19 AHI1 LINGO4 P4HA2-AS1 RERE RP11-574K11.5 RPS26 RUVBL1 SLC22A5 ZNF76
Impedance of arm (left) 1.41 14 5 15.2 -0.58 2.8e-02 CTD-2020K17.3 DCAKD EEFSEC GSDMA JAZF1 KIF1B LRRC32 MED24 POLR3H RHOT1 RP5-1029K10.2 RPS26 RUVBL1 SMAD3
Arm fat mass (right) 0.92 5 2 6.1 -0.25 6.9e-01 IQCH PSMG1 RERE RPS26 SMAD3
Trunk predicted mass 1.54 8 7 21.2 0.90 1.6e-04 AC034220.3 DCAKD MSL1 P4HA2-AS1 RPS26 SLC22A5 STAT6 ZNF76
Standing height 2.11 14 10 30.3 0.70 1.1e-03 AC034220.3 DCAKD DDX5 DMWD FADS3 KIAA1109 KIF3A MSL1 OIP5-AS1 P4HA2-AS1 RP5-1029K10.2 SLC22A5 STAT6 ZNF76
Tense / 'highly strung' 1.16 1 0 0.0 0.00 1.0e+00 RERE
Seen doctor (GP) for nerves, anxiety, tension or depression 1.19 1 0 0.0 0.00 1.0e+00 MSL1
Hair/balding pattern: Pattern 4 1.81 8 1 3.0 -0.24 5.6e-01 CTD-2020K17.3 DCAKD DEXI FADS3 KIF1B RERE S100A11 SRA1
Birth weight of first child 1.62 1 0 0.0 0.00 1.0e+00 RPS26
Peak expiratory flow (PEF) 1.42 3 1 3.0 0.00 1.0e+00 ADAM19 SLC22A5 ZNF76
Medication: Paracetamol 1.52 2 0 0.0 0.00 1.0e+00 CARF STAT6
Headache pain in last month 2.09 4 1 3.0 0.93 7.0e-02 CARF DMWD RPS26 STAT6
Gout (self-reported) 1.32 1 1 3.0 0.00 1.0e+00 KIF5A
Hypothyroidism/myxoedema (self-reported) 3.00 6 4 12.1 0.00 1.0e+00 AHI1 BACH2 CD247 FADS3 FBXO18 RPS26
Medication: Ventolin 100micrograms inhaler 9.64 25 5 15.2 -0.98 9.8e-20 AC093642.3 AHI1 BACH2 C1orf43 CD247 CLEC16A CTD-2020K17.3 D2HGDH DEXI GSDMB IL18R1 KIAA1109 LRRC32 NDFIP1 PGAP3 POLR3H PRKRIR RPS26 SLC22A5 SLC25A46 SLC9A2 SMAD3 STAT6 THRA TLR1
Birth weight 1.33 1 1 3.0 0.00 1.0e+00 HHEX
Forced vital capacity (FVC), Best measure 1.18 8 2 6.1 0.75 3.3e-02 AHI1 CARF IQCH LINGO4 RP11-574K11.5 RPS26 STMN3 ZNF76
Body fat percentage 1.25 9 4 12.1 -0.85 3.6e-03 CARF DCAKD FLG IQCH OIP5-AS1 POLR3H PSMG1 RERE SMAD3
Leg fat percentage (right) 1.45 7 3 9.1 -1.00 2.0e-06 CARF DCAKD IQCH NRROS OIP5-AS1 RERE SMAD3
Arm fat-free mass (right) 1.36 7 6 18.2 0.99 2.1e-07 AC034220.3 DCAKD P4HA2-AS1 RPS26 SLC22A5 STAT6 ZNF76
Comparative body size at age 10 1.20 1 0 0.0 0.00 1.0e+00 SMAD3
Worry too long after embarrassment 1.20 2 0 0.0 0.00 1.0e+00 AHI1 IQCH
Seen a psychiatrist for nerves, anxiety, tension or depression 1.23 1 0 0.0 0.00 1.0e+00 FADS3
Wheeze or whistling in the chest in last year 9.45 45 15 45.5 -0.98 2.4e-36 AC093642.3 ADAM19 BACH2 C1orf43 CAMK4 CARF CD247 CLEC16A D2HGDH DCAKD DEXI DMWD DOCK9-AS2 FADS3 GSDMA GSDMB IL18R1 IL1R1 JAZF1 KIAA1109 LRRC32 MED24 MSL1 NRROS PGAP3 PRKRIR RERE RHOT1 RMI2 RP11-396B14.2 RP11-574K11.5 RP11-876N24.4 RP11-876N24.5 RP5-1029K10.2 RP5-1148A21.3 SLC22A5 SLC25A46 SLC9A2 SMAD3 STAT6 STMN3 THRA TRAPPC2L TSLP WDR36
Reason for reducing amount of alcohol drunk: Health precaution 1.34 1 0 0.0 0.00 1.0e+00 RPS26
Age at first live birth 1.21 1 0 0.0 0.00 1.0e+00 RPS26
Shortness of breath walking on level ground 1.38 1 0 0.0 0.00 1.0e+00 LRRC32
Qualifications: College or University degree 1.05 2 1 3.0 0.00 1.0e+00 RERE RPS26
Medication for pain relief, constipation, heartburn 1.20 1 1 3.0 0.00 1.0e+00 STAT6
Neck or shoulder pain in last month 1.18 1 0 0.0 0.00 1.0e+00 RPS26
Medication: Blood pressure 1.40 1 0 0.0 0.00 1.0e+00 RP5-1029K10.2
Migraine (self-reported) 1.59 2 1 3.0 0.00 1.0e+00 CARF STAT6
Medication: Ibuprofen 1.25 1 1 3.0 0.00 1.0e+00 STAT6
Medication: Allopurinol 1.29 1 1 3.0 0.00 1.0e+00 KIF5A
Medication: Seretide 50 evohaler 5.46 6 0 0.0 -0.99 3.1e-08 BACH2 D2HGDH IL18R1 P4HA2-AS1 SLC22A5 SMAD3
Whole body fat mass 1.00 4 2 6.1 -0.99 7.2e-03 FLG IQCH RERE SMAD3
Leg fat mass (right) 1.02 4 3 9.1 -0.59 4.1e-01 IQCH RERE RPS26 SMAD3
Arm predicted mass (right) 1.37 7 6 18.2 0.98 2.6e-07 AC034220.3 DCAKD P4HA2-AS1 RPS26 SLC22A5 STAT6 ZNF76
Pulse rate, automated reading 1.43 3 1 3.0 0.00 1.0e+00 FADS3 PCGF2 RPS26
Alcohol intake frequency. 1.16 2 0 0.0 0.00 1.0e+00 RPS26 STAT6
Comparative height size at age 10 1.82 10 5 15.2 0.66 1.5e-02 AC034220.3 C1orf43 DMWD FAM89B HHEX MSL1 P4HA2-AS1 SLC22A5 SMAD3 ZNF76
Overall health rating 1.13 1 0 0.0 0.00 1.0e+00 DCAKD
Chest pain or discomfort 1.84 1 0 0.0 0.00 1.0e+00 DCAKD
Supplements: Vitamin C 1.11 1 0 0.0 0.00 1.0e+00 GSDMB
Knee pain experienced in last month 1.84 2 0 0.0 0.00 1.0e+00 DEXI RP11-396B14.2
Hypertension (Self-reported) 1.70 8 2 6.1 -0.83 1.7e-03 AC034220.3 DCAKD OIP5-AS1 P4HA2-AS1 RERE RPS26 RUVBL1 SLC22A5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.04 1 0 0.0 0.00 1.0e+00 DCAKD
Illnesses of father: Heart disease 1.47 1 0 0.0 0.00 1.0e+00 SMAD3
Forced expiratory volume in 1-second (FEV1), predicted 1.81 5 4 12.1 0.83 1.1e-02 AC034220.3 FADS3 P4HA2-AS1 SLC22A5 ZNF76
Whole body fat-free mass 1.45 8 7 21.2 0.90 1.8e-04 AC034220.3 DCAKD MSL1 P4HA2-AS1 RPS26 SLC22A5 STAT6 ZNF76
Leg fat-free mass (right) 1.34 9 4 12.1 0.82 1.2e-03 AC034220.3 DCAKD KIAA1109 MSL1 P4HA2-AS1 RPS26 SLC22A5 STAT6 ZNF76
Arm fat percentage (left) 1.08 8 3 9.1 -0.81 1.4e-02 CARF DCAKD IQCH OIP5-AS1 POLR3H PSMG1 RERE SMAD3
Mood swings 0.96 1 0 0.0 0.00 1.0e+00 POLR3H
Long-standing illness, disability or infirmity 2.40 3 0 0.0 0.00 1.0e+00 DCAKD IQCH RP5-1029K10.2
Diabetes diagnosed by doctor 1.39 2 1 3.0 0.00 1.0e+00 HHEX JAZF1
Asthma (self-reported) 23.50 77 55 166.7 -1.00 1.8e-97 AC034220.3 AC093642.3 ADAM19 AHI1 BACH2 C1orf43 CAMK4 CARF CD247 CLEC16A CTD-2020K17.3 CTD-2021H9.1 D2HGDH DCAKD DDX5 DEXI DMWD DOCK9-AS2 EEFSEC ENO1 FADS3 FBXO18 FLG GSDMA GSDMB HHEX IL18R1 IL1R1 IL4R IQCH JAZF1 KIAA1109 KIF1B KIF3A KIF5A KRT222 LINGO4 LRRC32 MED24 MSL1 NDFIP1 NRROS OIP5-AS1 P4HA2-AS1 PCGF2 PGAP3 POLR3H PPFIA4 PRKCQ PRKRIR RERE RMI2 RP11-396B14.2 RP11-574K11.5 RP11-876N24.4 RP11-876N24.5 RP5-1029K10.2 RP5-1148A21.3 RPS26 RUVBL1 S100A11 SLC22A5 SLC25A46 SLC9A2 SMAD3 SPATA5 SRA1 STAT6 STMN3 TDRKH THRA TLR1 TNFSF18 TRAPPC2L TSLP WDR36 ZNF76
Illnesses of father: None of the above (group 1) 1.50 1 0 0.0 0.00 1.0e+00 SMAD3
Smoking status: Current 1.51 3 0 0.0 0.00 1.0e+00 CARF POLR3H STMN3
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.11 5 2 6.1 0.85 6.7e-02 ADAM19 GSDMB PCGF2 PGAP3 STMN3
Whole body water mass 1.47 9 7 21.2 0.83 8.4e-04 AC034220.3 DCAKD KIAA1109 MSL1 P4HA2-AS1 RPS26 SLC22A5 STAT6 ZNF76
Leg predicted mass (right) 1.35 7 4 12.1 0.88 9.1e-04 AC034220.3 DCAKD KIAA1109 P4HA2-AS1 RPS26 SLC22A5 STAT6
Arm fat mass (left) 0.92 5 2 6.1 -0.28 6.5e-01 IQCH PSMG1 RERE RPS26 SMAD3
Number of self-reported non-cancer illnesses 4.84 13 2 6.1 -0.96 6.7e-09 D2HGDH DCAKD DEXI GSDMB IQCH KIF3A LRRC32 P4HA2-AS1 RP11-396B14.2 RP5-1029K10.2 RUVBL1 SLC22A5 STMN3
Average weekly champagne plus white wine intake 1.34 1 0 0.0 0.00 1.0e+00 FADS3
Miserableness 1.49 2 0 0.0 0.00 1.0e+00 MSL1 RERE
Wears glasses or contact lenses 1.43 1 0 0.0 0.00 1.0e+00 DDX5
Medication: Blood pressure 1.97 4 1 3.0 -0.99 1.6e-04 AC034220.3 KIF3A P4HA2-AS1 SLC22A5
Supplements: Fish oil (including cod liver oil) 1.43 1 0 0.0 0.00 1.0e+00 DCAKD
High cholesterol (Self-reported) 1.16 1 0 0.0 0.00 1.0e+00 CARF
Medication: Bendroflumethiazide 1.92 3 0 0.0 -0.97 5.1e-03 AC034220.3 P4HA2-AS1 SLC22A5
Medication: Paracetamol 1.30 1 0 0.0 0.00 1.0e+00 DCAKD
Ever smoked 1.23 3 0 0.0 0.00 1.0e+00 IQCH PGAP3 PSMG1
Basal metabolic rate 1.36 9 5 15.2 0.83 9.2e-04 AC034220.3 DCAKD KIAA1109 MSL1 P4HA2-AS1 RPS26 SLC22A5 STAT6 ZNF76
Leg fat percentage (left) 1.48 8 2 6.1 -0.66 7.5e-02 CARF DCAKD GSDMA IQCH OIP5-AS1 RERE RHOT1 SMAD3
Arm fat-free mass (left) 1.37 7 5 15.2 0.98 2.3e-07 AC034220.3 DCAKD P4HA2-AS1 RPS26 SLC22A5 STAT6 ZNF76
Number of operations (self-reported) 1.89 2 0 0.0 -1.00 3.8e-03 DEXI IQCH
Average weekly beer plus cider intake 1.84 1 0 0.0 0.00 1.0e+00 STAT6
Irritability 1.01 1 0 0.0 0.00 1.0e+00 FADS3
Diastolic blood pressure, automated reading 1.66 9 3 9.1 -0.75 1.2e-02 AC034220.3 CARF DCAKD HHEX OIP5-AS1 P4HA2-AS1 RERE RP5-1029K10.2 RPS26
Myopia 1.25 2 0 0.0 0.00 1.0e+00 GSDMB STAT6
Vascular/heart problems diagnosed by doctor 1.83 10 3 9.1 0.62 2.3e-02 AC034220.3 DCAKD OIP5-AS1 P4HA2-AS1 RERE RP5-1029K10.2 RPS26 RUVBL1 SLC22A5 SMAD3
Cholesterol lowering medication 1.12 1 0 0.0 0.00 1.0e+00 CARF
Pain experienced in last month 1.60 1 0 0.0 0.00 1.0e+00 RPS26
Basal cell carcinoma (self-reported) 1.38 1 0 0.0 0.00 1.0e+00 POLR3H
Heart attack/myocardial infarction (self-reported) 1.48 1 0 0.0 0.00 1.0e+00 CARF
Impedance of whole body 1.26 10 6 18.2 -0.50 1.2e-01 DCAKD EEFSEC JAZF1 KIF1B LRRC32 POLR3H RHOT1 RP5-1029K10.2 RPS26 RUVBL1
Leg fat mass (left) 1.01 7 3 9.1 -0.31 5.0e-01 CARF FLG GSDMA IQCH RERE RPS26 SMAD3
Arm predicted mass (left) 1.39 7 4 12.1 0.98 4.6e-07 AC034220.3 DCAKD P4HA2-AS1 RPS26 SLC22A5 STAT6 ZNF76

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 13 0.3723 2.13
GTEx Adipose Visceral Omentum 8 0.3927 2.20
GTEx Adrenal Gland 3 0.2059 1.97
GTEx Artery Aorta 15 0.5039 2.18
GTEx Artery Coronary 1 0.0845 1.97
GTEx Artery Tibial 20 0.5322 2.22
GTEx Brain Caudate basal ganglia 5 0.5435 2.05
GTEx Brain Cerebellar Hemisphere 3 0.2015 2.22
GTEx Brain Cerebellum 6 0.3026 2.20
GTEx Brain Cortex 7 0.6770 2.25
GTEx Brain Frontal Cortex BA9 5 0.5405 2.31
GTEx Brain Hippocampus 2 0.3810 1.85
GTEx Brain Hypothalamus 2 0.3384 2.30
GTEx Brain Nucleus accumbens basal ganglia 7 0.8083 2.38
GTEx Brain Putamen basal ganglia 5 0.8013 2.24
GTEx Breast Mammary Tissue 14 0.7089 2.35
GTEx Breast Mammary Tissue (Male) 9 0.7544 2.39
GTEx Breast Mammary Tissue (Female) 9 0.5471 2.15
GTEx Cells EBV-transformed lymphocytes 7 0.4926 2.03
GTEx Cells Transformed fibroblasts 26 0.6193 2.36
GTEx Colon Sigmoid 8 0.5468 2.25
GTEx Colon Transverse 11 0.5327 2.36
GTEx Esophagus Gastroesophageal Junction 7 0.4844 2.07
GTEx Esophagus Mucosa 16 0.4818 2.20
GTEx Esophagus Muscularis 14 0.4332 2.18
GTEx Heart Atrial Appendage 8 0.5063 2.46
GTEx Heart Left Ventricle 5 0.3266 2.04
GTEx Liver 3 0.4184 2.04
GTEx Lung 12 0.4177 2.27
GTEx Muscle Skeletal 15 0.5187 2.19
GTEx Nerve Tibial 21 0.4857 2.22
GTEx Ovary 7 0.7701 2.20
GTEx Pancreas 10 0.6124 2.42
GTEx Pituitary 7 0.6272 2.25
GTEx Prostate 5 0.5995 2.16
GTEx Skin Not Sun Exposed Suprapubic 22 0.8943 2.37
GTEx Skin Sun Exposed Lower leg 23 0.6324 2.40
GTEx Small Intestine Terminal Ileum 1 0.2165 1.85
GTEx Spleen 10 0.7087 2.49
GTEx Stomach 6 0.4124 2.11
GTEx Testis 24 0.7602 2.19
GTEx Thyroid 28 0.7005 2.33
GTEx Uterus 3 0.5291 2.04
GTEx Vagina 1 0.1575 1.74
GTEx Whole Blood 14 0.7035 2.52
METSIM Adipose 22 0.4777 2.17
NTR Blood 22 0.9159 2.39
ROSMAP Brain Pre-frontal Cortex 22 0.5011 2.15
YFS Blood 31 0.6717 2.28
CommonMind Brain Pre-frontal Cortex 30 0.5579 2.15
TCGA Breast Tumor 5 0.6527 2.49
TCGA Breast Normal 16 0.3803 1.97
TCGA Ovarian Tumor 7 0.2395 1.99
TCGA Prostate Tumor 14 0.4050 2.16