TWAS hub - SLC7A1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0659	0.0297	1.2e-02	0.017	0.005	0.011	0.014	0.017	1.2e-03	4.8e-02	7.5e-03	3.2e-03	1.1e-03
2	YFS	Blood	0.1386	0.0239	1.7e-16	0.063	0.067	0.114	0.100	0.114	6.3e-20	4.4e-21	2.8e-35	8.4e-31	3.9e-35

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Illnesses of mother	8.7	10.7	21.3	-4.6	0.2
Medication: Blood pressure	8.3	15.8	29.0	5.4	1.6
Medication: Bendroflumethiazide	8.3	12.7	24.3	4.9	1.0
Hair/balding pattern: Pattern 2	5.8	7.4	13.0	1.3	3.6
Medication for cholesterol	5.0	7.6	14.1	-3.8	-1.0
Medication: Lisinopril	4.2	5.4	10.8	3.3	0.0
Systolic Blood Pressure	4.0	19.9	26.9	5.2	3.6
Leg pain on walking	4.0	5.0	6.2	-1.9	-2.5
High blood pressure (mother)	3.6	5.0	10.0	3.2	-0.2
Medication: Amlodipine	3.5	4.9	8.6	2.9	-1.1
Medication: Atenolol	3.3	4.2	4.6	1.9	2.1
Medication: Blood pressure	3.3	5.8	10.1	3.2	-1.2
Maternal smoking around birth	3.2	4.7	4.7	2.1	2.2
High blood pressure	3.2	8.9	17.0	4.1	0.9
Hypertension (Self-reported)	3.1	8.6	17.0	4.1	0.5
Eye problems/disorders: Diabetes related eye disease	3.0	3.3	5.6	-2.4	1.0
Tinnitus: Yes, but not now, but have in the past	3.0	3.2	5.9	2.4	-0.6
Vascular/heart problems diagnosed by doctor	3.0	8.2	15.6	-4.0	-0.8
Hypothyroidism (self reported)	2.9	6.7	10.0	1.8	3.2
Prostate Cancer	2.7	3.8	6.7	0.9	-2.6
Medication: Levothyroxine sodium	2.7	4.6	9.2	0.1	3.0
Ever unenthusiastic/disinterested for a whole week	2.6	3.2	6.2	-2.5	0.5
Number of treatments/medications taken	2.4	4.2	4.6	2.1	-2.0
Commuting to job workplace: Cycle	2.4	2.9	5.6	0.3	2.4
Neck or shoulder pain in last month	2.3	3.3	3.5	1.8	-1.9
Alzheimer’s Disease (in mother)	2.2	2.5	2.7	1.5	1.6
Age at First Birth	2.2	3.2	6.4	-0.2	2.5
Cardiovascular Disease	2.2	7.4	14.3	3.8	0.8
Other serious medical condition/disability diagnosed by doctor	2.2	2.8	5.6	-0.1	-2.4
Hair/balding pattern: Pattern 3	2.2	3.2	5.9	-0.7	-2.4
Birth weight of first child	2.2	4.0	7.9	-0.2	-2.8
Supplements: Fish oil (including cod liver oil)	2.2	2.9	5.7	-0.1	-2.4
Medication for cholesterol, blood pressure or diabetes	2.1	3.5	6.4	-2.5	0.8
Alzheimer’s Disease (including proxy)	2.0	2.9	5.2	0.8	2.3
Loneliness, isolation	2.0	2.8	3.2	-1.5	-1.8
Glaucoma (self-reported)	1.9	2.3	3.4	-1.8	-1.1
Knee pain experienced in last month	1.9	2.9	5.7	-2.4	0.4
Severe depression (siblings)	1.8	2.0	2.9	-1.0	-1.7
Exposure to tobacco smoke outside home	1.8	2.4	4.6	-0.3	-2.2
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	4.1	0.2	2.0
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	2.6	-1.3	-1.6
Eye problems/disorders: Glaucoma	1.8	2.1	2.7	-1.6	-1.2
Mean Putamen Volume	1.7	2.0	3.9	-2.0	-0.2
Pack years adult smoking proportion	1.7	2.6	4.9	-0.5	2.2
Heel bone mineral density (BMD) T-score, automated (right)	1.7	3.8	4.1	1.9	-2.0
Happiness	1.7	2.0	3.1	-1.0	-1.8
Medication: Ventolin 100micrograms inhaler	1.7	2.2	4.2	2.1	0.3
Age started oral contraceptive pill	1.7	2.1	4.1	-2.0	0.4
Trunk fat-free mass	1.6	9.4	14.7	2.0	-3.8
Trunk predicted mass	1.6	9.4	14.3	2.1	-3.8
Pain experienced in last month	1.6	2.6	3.9	-1.2	2.0
Pain all over the body in last month	1.5	1.6	3.1	0.3	-1.8
Chronic bronchitis/emphysema (mother)	1.5	1.7	3.3	1.8	-0.4
Arm fat-free mass (right)	1.5	7.9	13.9	1.4	-3.7
Illnesses of siblings: Diabetes	1.5	1.8	3.3	-0.6	-1.8
Whole body water mass	1.5	8.3	12.5	2.0	-3.5
Ever taken oral contraceptive pill	1.5	1.6	1.8	1.3	1.2
Alcohol drinker status: Previous	1.5	1.7	3.2	-0.4	-1.8
Arm predicted mass (left)	1.5	7.4	13.7	1.1	-3.7
Father’s age at death	1.4	1.9	2.9	-1.7	-1.0
Whole body fat-free mass	1.4	8.2	12.2	2.1	-3.5
Handedness (chirality/laterality): Left-handed	1.4	1.7	3.5	-0.0	-1.9
Commuting to job workplace: Walk	1.4	1.5	1.6	1.2	1.3
Financial situation satisfaction	1.4	1.8	2.5	-1.6	-1.0
Illnesses of father: High blood pressure	1.4	1.8	1.8	1.4	1.3
Arm fat-free mass (left)	1.4	7.0	12.3	1.3	-3.5
Pack years of smoking	1.4	2.1	3.9	-0.5	2.0
Bipolar Disorder (2018)	1.3	2.0	4.0	-2.0	0.2
Blood clot in the leg (DVT)	1.3	1.6	3.2	-0.3	-1.8
Arm predicted mass (right)	1.3	6.5	11.2	1.3	-3.4
Average weekly red wine intake	1.3	2.0	3.9	0.1	2.0
Basal metabolic rate	1.3	7.1	11.1	1.8	-3.3
Risk taking	1.3	1.8	2.4	1.6	-1.1
Intelligence (Savage-Jansen 2018)	1.2	3.8	4.7	-2.2	-1.7
Vitamin and mineral supplements	1.2	1.6	3.1	0.2	1.8
Hypothyroidism/myxoedema (self-reported)	1.2	2.4	4.2	0.8	2.0
Comparative body size at age 10	1.2	3.4	6.4	-0.7	2.5
Heart disease (mother)	1.2	1.5	3.0	0.1	-1.7
Pulse rate, automated reading	1.2	3.8	7.0	-2.6	-0.8
Leg fat-free mass (right)	1.2	6.4	7.2	2.4	-2.7
Illnesses of father: None of the above (group 1)	1.2	1.5	3.0	-0.3	-1.7
Smoking status: Current	1.2	1.9	3.8	-2.0	-0.1
Leg predicted mass (right)	1.2	6.4	7.3	2.3	-2.7
HbA1C	1.1	1.2	1.8	-1.3	-0.8
Angina	1.1	1.5	1.8	1.3	-1.1
Leg fat-free mass (left)	1.1	5.9	6.9	2.2	-2.6
Current tobacco smoking	1.1	1.8	3.5	-1.9	-0.3
Leg predicted mass (left)	1.1	6.0	7.5	2.1	-2.7
Had menopause	1.1	1.4	2.3	-1.5	-0.7
Diabetes (self-reported)	1.1	1.7	3.1	-1.8	-0.5
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	2.4	1.6	0.2
Depression (self-reported)	1.1	1.4	2.4	-0.6	-1.5
Medication for pain relief, constipation, heartburn	1.1	1.9	2.6	-1.1	1.6
Long-standing illness, disability or infirmity	1.1	1.6	3.0	0.6	-1.7
Qualifications: nursing, teaching	1.1	1.7	3.0	0.7	-1.7
Mineral and other dietary supplements	1.1	1.4	2.9	0.1	1.7
Deep venous thrombosis (DVT) (self-reported)	1.1	1.5	2.9	-0.2	-1.7
Impedance of whole body	1.1	5.8	7.1	-2.7	2.1
Ever had hysterectomy (womb removed)	1.0	1.1	1.6	-1.3	-0.8
Impedance of leg (right)	1.0	4.6	7.0	-2.6	1.5
Multivitamins +/- minerals	1.0	1.3	2.3	-0.5	-1.5
Hearing difficulty/problems with background noise	1.0	1.5	3.0	1.7	-0.0
Weight	1.0	4.7	8.4	1.0	-2.9
Alcohol intake versus 10 years previously	1.0	1.5	1.9	-1.1	-1.4
Impedance of arm (left)	1.0	4.6	6.3	-1.7	2.5
Peak expiratory flow (PEF)	1.0	2.4	3.9	2.0	-1.0
Birth weight	1.0	2.1	2.7	-1.6	-1.2
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	1.8	0.7	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	1.5	-0.9	1.2
Diabetes diagnosed by doctor	1.0	1.6	3.2	-1.8	-0.2
Back pain experienced in last month	1.0	1.4	1.6	1.2	-1.1
Medication: Atorvastatin	1.0	1.3	2.5	-0.0	1.6
Ever depressed for a whole week	1.0	1.2	1.5	-1.2	-1.0
Unable to work because of sickness or disability	1.0	1.3	2.5	-0.2	-1.6
Heart disease (siblings)	1.0	1.3	2.4	0.4	1.5
Neuroticism	0.9	2.1	3.4	-0.9	-1.8
Chronotype (morning person)	0.9	2.0	2.6	-1.6	1.2
Systolic blood pressure, automated reading	0.9	2.7	5.2	2.3	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	2.2	1.4	-1.5
Serious illness, injury or assault to yourself	0.9	1.1	2.2	1.5	0.1
Impedance of leg (left)	0.9	4.3	7.5	-2.7	1.1
Medication: Ramipril	0.9	1.1	1.8	0.7	-1.3
Noisy workplace	0.9	1.1	2.2	-1.5	-0.1
Age at last live birth	0.9	1.3	2.4	0.5	1.6
Mood swings	0.9	1.6	1.6	-1.3	-1.2
Osteoarthritis (self-reported)	0.9	1.1	2.2	-0.3	-1.5
Number of self-reported non-cancer illnesses	0.9	1.6	3.0	0.5	-1.7
Medication: Paracetamol	0.9	1.4	2.7	0.4	-1.6
Ever smoked	0.9	1.6	1.8	1.2	-1.3
Depressed Affect (Nagel 2018)	0.8	1.7	3.2	-0.6	-1.8
Alzheimer’s Disease (in father)	0.8	0.9	1.3	-0.6	1.2
Ulcerative Colitis	0.8	1.2	1.9	0.7	-1.4
Supplements: Zinc	0.8	0.9	1.7	1.3	-0.4
Average weekly fortified wine intake	0.8	1.0	1.8	1.3	0.4
Waist circumference	0.8	3.1	6.2	0.1	-2.5
Number of incorrect matches in round	0.8	1.4	2.2	0.7	1.5
Number of live births	0.8	1.1	1.9	-1.4	0.5
Prospective memory result	0.8	1.0	1.7	1.3	0.6
Lung cancer (father)	0.8	0.9	1.8	-0.2	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	4.5	0.8	-2.1
Medication: Paracetamol	0.8	1.3	2.4	0.4	-1.5
Angina (self-reported)	0.8	1.0	1.2	1.1	-0.9
Heel T-Score	0.7	5.3	5.6	2.2	-2.4
Type 2 Diabetes (T2D) (2018)	0.7	1.2	2.0	-1.4	-0.7
Allergy	0.7	1.6	3.1	-0.3	1.7
Impedance of arm (right)	0.7	3.4	5.2	-1.3	2.3
Hip circumference	0.7	2.8	5.1	0.7	-2.3
Falls in the last year	0.7	1.0	1.0	0.9	-1.0
Leg fat percentage (right)	0.7	2.6	2.9	-1.7	-1.5
Health satisfaction	0.7	0.9	0.9	-0.9	-0.9
Chest pain or discomfort	0.7	1.0	1.5	0.6	-1.2
Ever had bowel cancer screening	0.7	0.8	1.1	1.1	-0.7
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.5	-0.3	-1.2
Leg fat percentage (left)	0.7	2.6	3.0	-1.5	-1.7
Leg fat mass (left)	0.7	2.8	5.5	-0.3	-2.3
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.0	-0.6	-1.0
Hayfever, allergic rhinitis or eczema	0.6	1.3	2.6	0.2	-1.6
Trunk fat mass	0.6	2.7	5.3	-0.4	-2.3
Nervous feelings	0.6	1.0	1.6	-1.3	-0.7
Neuroticism score	0.6	1.2	1.4	-1.0	-1.2
Standing height	0.6	6.0	10.2	1.3	-3.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	1.2	1.1	0.5
Age at first live birth	0.6	1.0	1.9	1.4	0.4
Medication: Ibuprofen	0.6	0.7	1.0	-1.0	-0.7
Whole body fat mass	0.6	2.6	5.0	-0.4	-2.2
Leg fat mass (right)	0.6	2.2	4.3	-0.4	-2.1
Number of full sisters	0.6	0.7	1.3	0.2	-1.1
Suffer from ‘nerves’	0.6	0.9	1.2	-0.7	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.1	0.9	1.1
Average weekly beer plus cider intake	0.6	0.8	1.6	-1.3	0.1
Bipolar Disorder or Schizophrenia	0.5	1.3	2.3	-1.5	0.5
Ulcerative Colitis (UC)	0.5	1.0	1.9	0.0	-1.4
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.0	0.3	1.0
Height	0.5	10.6	20.4	0.9	-4.5
Respiratory disease	0.5	1.0	1.2	1.1	-1.0
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.2	-1.1	-0.0
Stomach or abdominal pain in last month	0.5	0.7	1.1	-0.5	-1.1
Chronic bronchitis/emphysema (father)	0.5	0.6	0.8	0.6	-0.9
Past tobacco smoking	0.5	0.9	1.5	-1.2	0.6
Pulse wave reflection index	0.5	0.6	0.7	-0.8	-0.7
Body fat percentage	0.5	1.8	2.0	-1.3	-1.4
Worry too long after embarrassment	0.5	0.9	1.7	0.3	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.1	-1.1	0.3
Shortness of breath walking on level ground	0.5	0.5	0.9	0.9	-0.4
Smoking status: Previous	0.5	0.8	1.6	1.3	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.5	0.9	1.6	1.3	0.5
Eye problems/disorders: Cataract	0.5	0.6	1.2	0.1	1.1
Arm fat mass (left)	0.5	2.1	4.1	0.3	-2.0
Miserableness	0.5	0.9	0.9	-0.9	-0.9
Hearing aid user	0.5	0.6	1.2	0.1	1.1
Mother’s age at death	0.5	0.6	1.2	-1.1	-0.2
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.1	0.2	-1.0
Ever had prostate specific antigen (PSA) test	0.5	0.6	0.9	1.0	-0.5
Diastolic blood pressure, automated reading	0.5	1.5	2.6	1.6	0.6
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.1	1.0	-0.5
Schizophrenia vs Biploar Disorder	0.4	0.5	1.0	0.1	1.0
Coronary Artery Disease (CAD)	0.4	0.4	0.8	0.9	0.2
Lupus	0.4	0.5	0.7	0.6	-0.8
Triglycerides	0.4	0.6	1.1	-1.0	-0.4
BMI	0.4	2.4	3.0	1.3	-1.7
Waist Hip Ratio (WHR)	0.4	1.9	2.7	-1.0	-1.6
Average weekly spirits intake	0.4	0.5	0.6	-0.8	-0.6
Frequency of depressed mood in last 2 weeks	0.4	0.6	0.7	-0.6	-0.9
Medication for hormone replacement therapy	0.4	0.4	0.8	0.1	-0.9
Trunk fat percentage	0.4	1.5	1.9	-1.1	-1.4
Age when periods started (menarche)	0.4	1.1	2.1	1.4	0.3
Qualifications: CSEs or equivalent	0.4	0.5	0.9	-0.0	1.0
Alcohol usually taken with meals	0.4	0.7	1.4	0.2	1.2
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.7	-0.8	-0.5
Arm fat mass (right)	0.4	1.8	3.6	0.2	-1.9
Breastfed as a baby	0.4	0.5	1.0	-0.0	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	0.6	-0.8	-0.7
Gout (self-reported)	0.4	0.5	0.9	-0.9	-0.3
Forced vital capacity (FVC), Best measure	0.4	1.5	2.2	0.9	-1.5
Wheeze or whistling in the chest in last year	0.4	0.8	0.8	-0.9	-0.9
Qualifications: College or University degree	0.4	1.3	2.1	0.8	1.4
Medication: Seretide 50 evohaler	0.4	0.5	0.7	0.9	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.0	1.0	0.1
Alcohol intake frequency.	0.4	0.9	1.0	0.8	-1.0
Comparative height size at age 10	0.4	2.3	3.6	-1.0	-1.9
Medication: Aspirin	0.4	0.5	0.9	0.2	-0.9
Supplements: Vitamin C	0.4	0.4	0.8	0.3	-0.9
Friendships satisfaction	0.4	0.5	1.0	-0.1	-1.0
Medication: Gliclazide	0.4	0.4	0.7	-0.3	-0.8
Fractured/broken bones in last 5 years	0.4	0.6	1.0	1.0	0.3
Irritable Bowel Disease (IBD)	0.3	0.7	1.3	0.3	-1.1
Ovarian Cancer	0.3	0.4	0.7	-0.9	0.3
Allergy or Eczema	0.3	0.7	0.9	0.7	-1.0
Hand grip strength (left)	0.3	0.8	1.4	-0.4	-1.2
Medication: Metformin	0.3	0.4	0.6	-0.6	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.4	-0.5	-0.6
Body mass index (BMI)	0.3	1.2	2.3	0.3	-1.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.5	-0.5	-0.7
Mouth/teeth dental problems	0.3	0.5	0.8	-0.9	-0.4
Medication: Simvastatin	0.3	0.4	0.8	0.9	-0.2
Fluid intelligence score	0.3	0.6	1.3	-0.1	-1.1
Asthma	0.3	0.5	0.7	0.6	-0.8
Medication: Cholesterol lowering	0.3	0.4	0.9	0.9	-0.1
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.8	0.1	-0.9
Number of full brothers	0.3	0.4	0.7	0.3	-0.8
Number of children fathered	0.3	0.3	0.3	-0.5	-0.6
Mean time to correctly identify matches	0.3	0.6	1.2	1.1	-0.1
Family relationship satisfaction	0.3	0.3	0.6	-0.2	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.8	-0.9	0.0
Supplements: Calcium	0.3	0.3	0.6	0.1	-0.8
Depression (Nagel 2018)	0.2	0.3	0.5	0.7	-0.3
Reaction Time	0.2	0.3	0.6	0.8	-0.2
Crohns Disease (2012)	0.2	0.4	0.7	0.8	-0.1
HDL Cholesterol	0.2	0.3	0.5	-0.7	0.1
Schizophrenia (2014)	0.2	0.4	0.6	-0.5	0.8
Blood White Count	0.2	1.2	1.9	-0.7	-1.4
Fed-up feelings	0.2	0.3	0.5	-0.7	-0.4
Supplements: Glucosamine	0.2	0.2	0.4	-0.2	-0.6
Sitting height	0.2	1.5	2.8	0.5	-1.7
Had other major operations	0.2	0.3	0.5	0.4	-0.7
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.4	0.7	0.3
Illnesses of siblings	0.2	0.3	0.6	-0.8	0.0
Arm fat percentage (right)	0.2	0.8	1.6	-0.2	-1.3
Time employed in main current job	0.2	0.2	0.3	-0.5	0.4
Worrier / anxious feelings	0.2	0.4	0.7	0.4	0.8
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.2	1.1	-0.6
Pulse wave Arterial Stiffness index	0.2	0.2	0.2	0.4	-0.5
Hair/balding pattern: Pattern 4	0.2	0.5	1.1	0.1	-1.0
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.4	0.6	0.6
Overall health rating	0.2	0.5	1.0	0.0	-1.0
Had major operations	0.2	0.2	0.3	-0.2	-0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.3	0.4	-0.5
Arm fat percentage (left)	0.2	0.7	1.3	-0.4	-1.2
Asthma (self-reported)	0.2	0.4	0.4	0.6	-0.6
Medication: Aspirin	0.2	0.3	0.5	0.2	-0.7
Average weekly champagne plus white wine intake	0.2	0.3	0.3	0.5	0.6
Guilty feelings	0.2	0.3	0.6	-0.1	0.8
Commuting to job workplace: Public transport	0.2	0.3	0.6	0.8	-0.1
Alcohol drinker status: Never	0.2	0.2	0.3	0.4	-0.5
Neuroticism (Nagel 2018)	0.1	0.2	0.4	-0.2	-0.7
Schizophrenia (2018)	0.1	0.2	0.3	-0.4	0.5
Worry (Nagel 2018)	0.1	0.2	0.4	0.3	-0.6
Major Depression (MDD)	0.1	0.1	0.2	-0.5	-0.1
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.5	-0.7	-0.4
Breast Cancer	0.1	0.2	0.2	-0.5	0.3
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	0.5	0.1
Fasting Glucose	0.1	0.1	0.2	0.4	-0.2
LDL Cholesterol	0.1	0.2	0.4	-0.1	-0.6
Primary Biliary Cirrhosis	0.1	0.1	0.2	0.3	-0.4
Rheumatoid Arthritis	0.1	0.1	0.2	-0.4	0.3
Blood Platelet Count	0.1	0.6	0.7	-0.8	0.7
Blood Red Count	0.1	0.6	0.7	-0.7	-0.8
Smoking Status	0.1	0.2	0.5	-0.7	0.1
Lung FEV1/FVC ratio	0.1	0.7	1.3	0.2	-1.1
Hair Pigment	0.1	3.3	3.5	1.8	1.9
Sensitivity / hurt feelings	0.1	0.2	0.4	0.1	0.6
Medication: Co-codamol	0.1	0.1	0.2	-0.3	-0.5
Diabetes (father)	0.1	0.1	0.2	-0.4	0.3
Townsend deprivation index at recruitment	0.1	0.2	0.3	0.3	0.6
Relative age voice broke	0.1	0.1	0.2	0.2	0.5
Taking other prescription medications	0.1	0.2	0.2	0.5	-0.3
Forced vital capacity (FVC)	0.1	0.5	0.9	1.0	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.3	-0.2	0.6
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.2	0.4	0.4
Mouth/teeth dental problems: Dentures	0.1	0.2	0.3	0.3	0.6
Length of working week for main job	0.1	0.1	0.2	0.5	0.2
Exposure to tobacco smoke at home	0.1	0.1	0.1	-0.3	-0.2
Tense / ‘highly strung’	0.1	0.1	0.2	-0.2	-0.4
Loud music exposure frequency	0.1	0.2	0.3	0.0	0.6
Headache pain in last month	0.1	0.1	0.1	0.4	-0.3
High blood pressure (siblings)	0.1	0.2	0.2	0.5	-0.3
Pulse wave peak to peak time	0.1	0.1	0.1	-0.4	0.2
Eye problems/disorders: None of the above	0.1	0.1	0.2	0.4	-0.3
Emphysema/chronic bronchitis	0.1	0.1	0.2	0.4	-0.2
Medication: Allopurinol	0.1	0.1	0.3	-0.5	0.1
Medication: Omeprazole	0.1	0.1	0.2	0.4	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.1	-0.2	-0.4
Breast cancer (self-reported)	0.1	0.1	0.3	0.1	-0.5
Osteoporosis (self-reported)	0.1	0.1	0.2	-0.4	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.4	-0.6	-0.4
Wears glasses or contact lenses	0.1	0.1	0.2	-0.2	-0.5
High cholesterol (Self-reported)	0.1	0.2	0.3	0.1	0.6
Irritability	0.1	0.1	0.1	-0.4	-0.4
Myopia	0.1	0.1	0.1	-0.3	-0.3
Basal cell carcinoma (self-reported)	0.1	0.2	0.3	0.5	-0.1
Crohns Disease (2017)	0.0	0.0	0.0	-0.1	-0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	-0.0	-0.1
Neuroticism (2016)	0.0	0.1	0.1	-0.3	-0.3
Blood Eosinophil Count	0.0	0.0	0.0	-0.2	-0.1
Lung FVC	0.0	0.1	0.2	-0.4	-0.3
Tanning	0.0	0.5	0.8	-0.3	-0.9
Hearing difficulty/problems: Yes	0.0	0.0	0.0	0.1	-0.1
Relative age of first facial hair	0.0	0.0	0.0	-0.1	0.2
Diabetes (mother)	0.0	0.0	0.0	-0.0	0.2
Hand grip strength (right)	0.0	0.1	0.2	0.0	-0.4
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.0	0.1	-0.1
Qualifications: None of the above	0.0	0.1	0.1	-0.3	-0.2
Financial difficulties in last 2 years	0.0	0.1	0.1	0.1	-0.3
Heart attack	0.0	0.0	0.0	-0.1	-0.0
Pulse rate	0.0	0.1	0.1	-0.2	-0.2
Medication: Lansoprazole	0.0	0.0	0.0	0.1	0.1
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.1	-0.3	-0.0
Migraine (self-reported)	0.0	0.0	0.1	-0.0	0.2
Illnesses of father: Heart disease	0.0	0.0	0.0	0.1	-0.0
Number of operations (self-reported)	0.0	0.0	0.0	-0.1	0.1
Cholesterol lowering medication	0.0	0.1	0.1	0.2	0.3
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.0	-0.2	-0.2

Hub : Genes

SLC7A1

Models

Trait associations