TWAS hub - ABCA12

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0590	0.0290	0.01700	0.012	0.010	0.006	0.012	0.005	1.1e-02	0.02100	0.04900	0.013	0.07900
2	TCGA	Breast Invasive Carcinoma	0.0489	0.0186	0.00015	0.020	0.017	0.015	NA	0.016	4.7e-05	0.00015	0.00037	NA	0.00025

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Medication: Blood pressure	7.4	14.0	28.0	-5.3	-0.3
Breast cancer (self-reported)	5.0	6.0	12.0	0.0	3.5
Systolic blood pressure, automated reading	4.7	13.6	23.9	-4.9	-1.8
Age at first live birth	4.6	8.2	13.3	3.6	-1.8
Peak expiratory flow (PEF)	4.5	10.4	20.6	4.5	0.5
Heart disease (mother)	4.4	5.3	10.4	-3.2	0.5
Medication for cholesterol	4.4	6.6	13.2	3.6	0.0
Vascular/heart problems diagnosed by doctor	4.3	11.8	22.8	4.8	0.9
High blood pressure (mother)	4.2	5.9	7.0	-2.6	-2.2
Ever depressed for a whole week	4.2	5.1	10.2	0.0	3.2
Systolic Blood Pressure	4.1	20.6	39.6	-6.3	-1.2
High blood pressure	4.1	11.5	22.3	-4.7	-0.8
Prospective memory result	4.0	5.0	8.1	2.9	1.3
Heart disease (siblings)	4.0	4.9	7.5	-2.7	1.5
Hypertension (Self-reported)	3.9	10.8	21.4	-4.6	-0.4
Illnesses of father: None of the above (group 1)	3.7	4.5	9.0	3.0	-0.2
Supplements: Zinc	3.6	3.9	6.9	-0.9	-2.6
Illnesses of mother	3.3	4.1	7.0	2.6	1.1
Ever had stillbirth, spontaneous miscarriage or termination	3.3	3.5	7.0	2.6	0.1
Supplements: Calcium	3.3	3.7	6.9	2.6	0.6
Cholesterol lowering medication	3.0	4.4	8.6	-2.9	-0.5
Hand grip strength (left)	2.7	7.1	12.5	3.5	1.3
Supplements: Vitamin C	2.7	3.2	6.3	2.5	0.1
Bilateral oophorectomy (both ovaries removed)	2.6	3.0	6.1	-2.5	0.0
Medication: Levothyroxine sodium	2.6	4.4	4.6	-2.1	-2.0
Financial difficulties in last 2 years	2.5	3.3	6.7	-2.6	0.0
Stomach or abdominal pain in last month	2.4	3.0	5.6	0.6	-2.4
Tinnitus: Yes, now most or all of the time	2.4	2.8	4.3	2.1	-1.1
Medication: Bendroflumethiazide	2.4	3.7	6.5	-2.5	-1.0
Bipolar Disorder (2011)	2.3	2.2	2.4	1.4	1.6
Forced expiratory volume in 1-second (FEV1)	2.3	7.9	15.2	3.9	0.8
Illnesses of father: Heart disease	2.3	3.2	6.4	-2.5	-0.2
Medication: Ibuprofen (e.g. Nurofen)	2.2	2.8	3.3	-1.6	1.8
Mean Putamen Volume	2.1	2.4	2.6	1.6	-1.5
Depressed Affect (Nagel 2018)	2.0	4.2	4.5	-2.1	2.0
Townsend deprivation index at recruitment	2.0	2.8	5.5	-0.3	2.3
Forced vital capacity (FVC)	2.0	7.8	15.0	3.9	0.8
Asthma	2.0	4.0	4.2	-2.0	1.9
Medication: Ventolin 100micrograms inhaler	2.0	2.5	4.5	0.8	2.1
Medication: Ibuprofen	2.0	2.4	3.6	-1.0	1.9
Medication: Seretide 50 evohaler	2.0	2.4	3.6	1.9	1.1
Ever unenthusiastic/disinterested for a whole week	1.9	2.3	2.7	1.4	1.6
Average weekly champagne plus white wine intake	1.9	2.6	3.9	2.0	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.8	3.8	-1.4	1.9
Commuting to job workplace: Walk	1.8	1.9	2.9	1.7	0.9
Osteoporosis (self-reported)	1.8	2.3	4.2	2.0	0.6
Bipolar Disorder or Schizophrenia	1.7	4.2	7.1	1.1	2.7
Depression (Nagel 2018)	1.7	2.6	5.2	0.0	2.3
Waist Hip Ratio (WHR)	1.7	7.6	13.2	-3.6	-1.4
Number of treatments/medications taken	1.7	3.0	5.2	-2.3	0.9
Ever had hysterectomy (womb removed)	1.7	2.0	2.0	-1.4	-1.4
Angina	1.7	2.2	4.0	-2.0	-0.6
Medication: Simvastatin	1.7	2.5	4.8	-2.2	-0.4
Lung cancer (father)	1.7	2.0	3.9	2.0	0.2
Medication: Amlodipine	1.7	2.4	4.7	-2.2	-0.1
Number of full brothers	1.7	2.1	3.7	-1.9	0.7
Wheeze or whistling in the chest in last year	1.7	3.0	5.1	-1.0	2.2
Asthma (self-reported)	1.7	3.5	4.0	-1.7	2.0
Rheumatoid Arthritis	1.6	2.2	2.4	1.6	1.4
Cardiovascular Disease	1.6	5.4	9.4	-3.1	1.2
Heart attack	1.6	2.1	2.9	-1.7	-1.1
Illnesses of siblings	1.6	2.2	3.2	1.8	-1.1
Medication: Gliclazide	1.6	1.8	3.2	-0.6	-1.8
Heart attack/myocardial infarction (self-reported)	1.6	2.0	2.5	-1.6	-1.3
Type 2 Diabetes (T2D) (2012)	1.5	1.8	3.4	1.8	-0.3
Lung FVC	1.5	7.8	15.4	3.9	0.5
Hand grip strength (right)	1.5	4.1	5.7	2.4	1.6
Medication: Ramipril	1.5	1.9	3.2	-1.8	-0.8
Medication: Lansoprazole	1.5	1.7	3.2	1.8	-0.4
Pulse wave reflection index	1.5	1.9	2.2	1.2	-1.5
Ever highly irritable/argumentative for 2 days	1.5	1.8	3.3	0.5	1.8
Chest pain or discomfort	1.5	2.2	4.2	-2.1	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.1	5.1	2.3	1.0
Schizophrenia (2018)	1.4	3.0	3.7	1.5	1.9
Coronary Artery Disease (CAD)	1.4	1.6	3.3	0.1	-1.8
Medication: Co-codamol	1.4	1.6	3.1	-1.7	0.3
Relative age voice broke	1.4	2.2	4.3	-0.2	-2.1
Chronic bronchitis/emphysema (father)	1.4	1.7	3.4	-1.8	-0.0
Alcohol usually taken with meals	1.4	2.2	3.2	1.1	-1.8
Pulse rate	1.4	2.3	2.4	-1.5	1.5
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	4.7	2.2	0.1
Medication: Blood pressure	1.4	2.4	4.8	-2.2	-0.3
Number of self-reported non-cancer illnesses	1.4	2.5	3.8	-2.0	-1.1
Unable to work because of sickness or disability	1.4	1.8	3.3	1.8	-0.6
Schizophrenia vs Biploar Disorder	1.3	1.8	3.2	1.8	0.5
Chronotype (morning person)	1.3	3.1	5.5	2.4	0.8
Birth weight of first child	1.3	2.3	3.5	-1.9	1.1
Medication for pain relief, constipation, heartburn	1.3	2.2	3.4	1.8	-1.0
Family relationship satisfaction	1.3	1.6	2.8	-0.6	1.7
Miserableness	1.3	2.2	2.3	-1.5	1.4
Major Depression (MDD)	1.2	1.4	1.9	1.0	1.4
Blood White Count	1.2	9.1	18.0	-4.2	0.6
Hearing difficulty/problems: Yes	1.2	1.8	3.5	0.3	-1.9
Length of working week for main job	1.2	1.3	2.5	0.4	-1.6
Breastfed as a baby	1.2	1.5	3.0	1.7	-0.0
Forced vital capacity (FVC), Best measure	1.2	4.3	8.5	2.9	0.3
Angina (self-reported)	1.2	1.6	3.0	-1.7	-0.3
Age at last live birth	1.2	1.7	2.0	1.4	-1.2
Medication: Aspirin	1.2	1.6	2.9	-1.7	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.5	2.7	1.6	0.5
Medication: Lisinopril	1.2	1.6	2.0	-1.1	-1.4
Average weekly beer plus cider intake	1.2	1.7	3.1	0.6	1.8
Bipolar Disorder (2018)	1.1	1.7	3.3	-0.2	1.8
Ovarian Cancer	1.1	1.5	1.7	1.3	-1.1
Diabetes (father)	1.1	1.3	2.0	1.4	0.8
Maternal smoking around birth	1.1	1.5	3.0	0.2	-1.7
Qualifications: A levels/AS levels or equivalent	1.1	2.4	4.8	2.2	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.5	6.9	2.6	0.2
High cholesterol (Self-reported)	1.1	2.0	3.1	-1.8	-0.9
Respiratory disease	1.0	2.1	2.2	-1.5	1.4
Age when periods started (menarche)	1.0	2.3	3.1	1.8	-1.2
Had menopause	1.0	1.3	2.5	-0.4	-1.6
Fluid intelligence score	1.0	2.0	2.8	1.1	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.1	2.0	0.6	1.4
Ever had bowel cancer screening	1.0	1.1	1.2	-1.1	-1.0
Osteoarthritis (self-reported)	1.0	1.3	2.4	-0.4	-1.5
Mother’s age at death	1.0	1.2	2.4	1.5	0.3
Eye problems/disorders: Glaucoma	1.0	1.2	2.2	-0.4	1.5
HbA1C	0.9	1.0	1.9	0.0	1.4
Waist circumference	0.9	3.2	3.8	-2.0	-1.6
Nervous feelings	0.9	1.6	1.8	1.4	-1.2
Mouth/teeth dental problems: Dentures	0.9	1.5	3.0	-1.7	0.0
Tense / ‘highly strung’	0.9	1.6	3.1	0.3	1.7
Qualifications: College or University degree	0.9	2.9	5.8	2.4	-0.1
Emphysema/chronic bronchitis	0.9	1.0	2.0	1.4	0.1
Had major operations	0.9	1.1	1.5	0.8	-1.2
Fractured/broken bones in last 5 years	0.9	1.2	1.9	-0.7	1.4
Neuroticism (Nagel 2018)	0.8	1.8	3.4	-0.3	1.9
Alzheimer’s Disease (in mother)	0.8	0.9	1.3	-1.2	0.7
LDL Cholesterol	0.8	1.2	2.2	1.5	0.6
Schizophrenia (2014)	0.8	1.7	2.2	1.5	1.1
Ulcerative Colitis	0.8	1.2	1.5	1.2	0.9
Hair/balding pattern: Pattern 4	0.8	2.0	3.7	0.5	1.9
Exposure to tobacco smoke outside home	0.8	1.1	1.8	-1.3	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.0	0.2	1.4
Medication: Omeprazole	0.8	0.9	1.5	0.5	1.2
Pulse rate, automated reading	0.8	2.5	2.8	-1.7	1.5
Medication: Aspirin	0.8	1.0	2.0	-1.4	-0.2
Guilty feelings	0.8	1.3	1.3	1.1	1.1
Alcohol drinker status: Never	0.8	1.0	1.7	-1.3	-0.5
Diastolic blood pressure, automated reading	0.8	2.6	5.3	-2.3	0.1
Alzheimer’s Disease (including proxy)	0.7	1.1	1.1	-1.0	1.1
Ulcerative Colitis (UC)	0.7	1.4	1.7	1.3	1.1
Age at First Birth	0.7	1.0	2.0	1.4	0.3
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.4	1.2	-0.4
Medication: Atenolol	0.7	0.9	1.7	-1.3	-0.3
Sitting height	0.7	5.0	9.8	3.1	0.4
Mouth/teeth dental problems	0.7	1.1	1.6	1.3	-0.8
Diabetes (self-reported)	0.7	1.1	2.1	-1.5	-0.0
Alcohol intake versus 10 years previously	0.7	1.0	1.7	-1.3	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.2	1.1	0.5
Loud music exposure frequency	0.7	0.8	0.8	0.9	0.9
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.9	-1.4	-0.1
Financial situation satisfaction	0.7	0.9	1.4	-1.2	-0.6
Ever smoked	0.7	1.3	2.2	-0.6	1.5
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.0	1.0	0.9
Worry (Nagel 2018)	0.6	1.2	1.5	0.9	1.2
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.4	-1.2	0.2
Medication: Metformin	0.6	0.9	1.6	-1.3	0.3
Qualifications: CSEs or equivalent	0.6	0.8	1.5	-1.2	-0.2
Number of incorrect matches in round	0.6	1.0	1.3	-1.2	-0.8
Arm fat percentage (right)	0.6	2.3	3.6	-1.9	-1.0
Father’s age at death	0.6	0.8	1.6	1.3	-0.2
Number of live births	0.6	0.9	1.8	-1.3	-0.1
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	1.3	-1.1	-1.0
High blood pressure (siblings)	0.6	0.9	1.7	-1.3	-0.4
Body fat percentage	0.6	2.2	3.9	-2.0	-0.7
Eye problems/disorders: None of the above	0.6	0.7	1.4	0.0	-1.2
Illnesses of siblings: Diabetes	0.6	0.8	0.8	-0.9	0.9
Smoking status: Previous	0.6	1.0	1.2	-1.1	0.8
Arm fat percentage (left)	0.6	2.4	3.2	-1.8	-1.2
Diabetes diagnosed by doctor	0.6	1.0	1.9	-1.4	0.4
Qualifications: nursing, teaching	0.6	0.9	1.7	1.3	-0.4
Leg fat percentage (left)	0.6	2.2	3.9	-2.0	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.6	-0.1	-1.3
Neuroticism (2016)	0.5	0.7	1.1	1.0	0.5
Relative age of first facial hair	0.5	1.0	2.0	0.4	-1.4
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	0.7	0.8	0.6
Severe depression (siblings)	0.5	0.5	0.5	-0.7	0.7
Trunk fat percentage	0.5	2.0	3.5	-1.9	-0.7
Past tobacco smoking	0.5	1.0	1.0	1.0	-1.0
Qualifications: None of the above	0.5	1.1	1.5	-1.2	0.8
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.0	1.0	0.7
Exposure to tobacco smoke at home	0.5	0.6	0.6	-0.8	0.8
Leg fat percentage (right)	0.5	1.7	3.4	-1.8	-0.3
Shortness of breath walking on level ground	0.5	0.6	0.7	-0.7	0.8
Leg pain on walking	0.5	0.6	1.0	1.0	0.5
Handedness (chirality/laterality): Left-handed	0.5	0.6	0.7	-0.7	-0.8
Ever taken oral contraceptive pill	0.5	0.5	1.1	-1.0	0.1
Pain type(s) experienced in last month: Hip pain	0.5	0.6	0.8	0.9	-0.7
Commuting to job workplace: Cycle	0.5	0.6	1.1	1.0	-0.2
Crohns Disease (2017)	0.4	1.0	1.1	1.0	-0.9
Irritable Bowel Disease (IBD)	0.4	0.9	1.8	1.3	0.0
Reaction Time	0.4	0.8	1.0	0.8	1.0
Breast Cancer	0.4	1.0	1.5	-1.2	-0.7
Heel T-Score	0.4	3.2	5.4	2.3	1.0
Average weekly spirits intake	0.4	0.5	0.8	0.9	0.6
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.2	0.0	1.1
Multivitamins +/- minerals	0.4	0.5	0.6	-0.6	-0.8
Supplements: Glucosamine	0.4	0.5	0.8	0.9	0.4
Trunk fat-free mass	0.4	2.1	4.0	2.0	0.3
Trunk predicted mass	0.4	2.0	4.0	2.0	0.2
Glaucoma (self-reported)	0.4	0.4	0.6	0.5	0.8
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.0	0.1	1.0
Mean time to correctly identify matches	0.4	0.8	1.5	-0.4	1.2
Whole body fat mass	0.4	1.5	2.1	-1.4	-1.0
Mood swings	0.4	0.7	1.2	-0.4	1.1
Long-standing illness, disability or infirmity	0.4	0.6	0.6	-0.7	0.8
Eye problems/disorders: Cataract	0.4	0.5	0.8	0.9	-0.3
Wears glasses or contact lenses	0.4	0.5	0.9	-1.0	0.1
Supplements: Fish oil (including cod liver oil)	0.4	0.6	0.8	-0.5	0.9
Medication: Paracetamol	0.4	0.6	1.2	-0.3	1.1
Illnesses of father: High blood pressure	0.4	0.6	0.7	-0.6	-0.9
Irritability	0.4	0.7	1.0	1.0	0.7
Alzheimer’s Disease (in father)	0.3	0.4	0.5	-0.5	0.7
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.0	0.6	-1.0
Prostate Cancer	0.3	0.4	0.5	0.6	0.7
Lupus	0.3	0.5	1.0	-0.1	-1.0
Triglycerides	0.3	0.5	0.6	-0.7	0.6
Blood Platelet Count	0.3	3.5	4.2	-2.0	-1.7
Type 2 Diabetes (T2D) (2018)	0.3	0.6	0.9	-0.6	1.0
Neuroticism	0.3	0.7	1.3	0.4	1.1
Vitamin and mineral supplements	0.3	0.4	0.5	-0.7	0.6
Fed-up feelings	0.3	0.6	1.3	-1.1	-0.0
Serious illness, injury or assault to yourself	0.3	0.4	0.6	0.8	0.5
Trunk fat mass	0.3	1.2	1.7	-1.3	-0.8
Blood clot in the leg (DVT)	0.3	0.3	0.7	-0.0	-0.8
Medication: Paracetamol	0.3	0.6	0.8	-0.9	0.6
Migraine (self-reported)	0.3	0.4	0.7	0.8	0.3
Alcohol intake frequency.	0.3	0.7	1.0	-1.0	-0.6
Number of full sisters	0.3	0.4	0.8	0.9	-0.3
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.7	0.8	-0.2
Average weekly red wine intake	0.3	0.5	0.7	0.5	-0.8
Mineral and other dietary supplements	0.3	0.4	0.7	-0.2	-0.9
Arm fat mass (left)	0.3	1.4	1.9	-1.4	-1.0
Number of operations (self-reported)	0.3	0.5	0.7	0.6	-0.8
Risk taking	0.3	0.5	0.9	0.3	0.9
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.8	0.9	-0.0
Myopia	0.3	0.4	0.8	0.9	-0.1
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.3	1.1	0.2
Blood Red Count	0.2	1.5	2.0	-1.4	1.0
BMI	0.2	0.9	1.7	-1.3	0.0
Hypothyroidism (self reported)	0.2	0.3	0.7	-0.8	-0.1
Tanning	0.2	1.9	3.8	-1.9	-0.2
Sensitivity / hurt feelings	0.2	0.3	0.4	-0.6	0.4
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.4	-0.3	-0.6
Medication for hormone replacement therapy	0.2	0.3	0.5	0.7	0.2
Average weekly fortified wine intake	0.2	0.2	0.4	-0.6	-0.1
Body mass index (BMI)	0.2	0.8	1.3	-1.1	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.3	0.5	-0.6
Allergy	0.2	0.4	0.5	0.7	0.6
Neuroticism score	0.2	0.4	0.9	0.1	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.6	0.8	0.1
Happiness	0.2	0.2	0.4	0.6	0.2
Medication: Cholesterol lowering	0.2	0.3	0.5	-0.7	-0.0
Impedance of arm (left)	0.2	0.7	0.8	-0.9	-0.8
Arm fat mass (right)	0.2	0.9	1.2	-1.1	-0.7
Standing height	0.2	1.7	3.3	1.8	0.1
Arm fat-free mass (right)	0.2	0.9	1.7	1.3	0.2
Comparative body size at age 10	0.2	0.5	1.0	0.2	1.0
Number of children fathered	0.2	0.2	0.3	-0.6	-0.3
Health satisfaction	0.2	0.3	0.4	0.3	0.7
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.4	-0.6	0.2
Neck or shoulder pain in last month	0.2	0.3	0.5	-0.2	0.7
Leg fat mass (right)	0.2	0.7	1.1	-1.0	-0.5
Arm predicted mass (right)	0.2	1.2	2.4	1.5	0.3
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	-0.2	-0.6
Whole body fat-free mass	0.2	1.2	2.3	1.5	0.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.2	0.4	-0.7	0.2
Back pain experienced in last month	0.2	0.3	0.5	-0.7	-0.4
Whole body water mass	0.2	1.2	2.3	1.5	0.2
Pain experienced in last month	0.2	0.3	0.5	-0.7	0.5
Alcohol drinker status: Previous	0.2	0.2	0.3	0.4	-0.6
Leg fat mass (left)	0.2	0.8	1.2	-1.1	-0.7
Body Mass Index (BMI) (2010)	0.1	0.2	0.3	-0.3	-0.5
Fasting Glucose	0.1	0.2	0.3	-0.2	-0.6
HDL Cholesterol	0.1	0.1	0.1	-0.3	0.3
Blood Eosinophil Count	0.1	0.5	0.9	0.1	1.0
Lung FEV1/FVC ratio	0.1	0.5	0.8	-0.9	-0.4
Diabetes (mother)	0.1	0.2	0.3	-0.5	0.3
Pack years adult smoking proportion	0.1	0.2	0.4	-0.1	0.6
Impedance of leg (right)	0.1	0.4	0.7	-0.3	0.9
Leg fat-free mass (left)	0.1	0.6	1.1	1.1	-0.2
Current tobacco smoking	0.1	0.2	0.3	0.5	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.2	-0.5	-0.1
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.4	-0.1	-0.6
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.1	-0.2	0.3
Impedance of leg (left)	0.1	0.4	0.6	-0.8	0.4
Leg predicted mass (left)	0.1	0.6	1.1	1.1	-0.2
Hair/balding pattern: Pattern 2	0.1	0.1	0.1	-0.3	0.2
Had other major operations	0.1	0.1	0.1	-0.4	-0.3
Impedance of arm (right)	0.1	0.6	1.1	-1.1	-0.3
Falls in the last year	0.1	0.2	0.3	-0.2	-0.5
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	-0.2	-0.5
Noisy workplace	0.1	0.1	0.1	-0.3	-0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	-0.1	-0.6
Headache pain in last month	0.1	0.3	0.4	-0.4	0.6
Gout (self-reported)	0.1	0.1	0.1	0.2	-0.4
Birth weight	0.1	0.3	0.4	-0.6	0.5
Worry too long after embarrassment	0.1	0.1	0.2	0.4	0.2
Medication: Allopurinol	0.1	0.1	0.2	0.1	-0.4
Suffer from ‘nerves’	0.1	0.1	0.1	0.3	0.2
Overall health rating	0.1	0.3	0.5	-0.4	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.1	-0.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.3	0.6	-0.3
Leg fat-free mass (right)	0.1	0.5	0.8	0.9	-0.3
Loneliness, isolation	0.1	0.1	0.3	-0.1	0.5
Friendships satisfaction	0.1	0.1	0.2	0.4	-0.3
Smoking status: Current	0.1	0.1	0.1	0.4	-0.2
Leg predicted mass (right)	0.1	0.4	0.8	0.9	-0.3
Hearing aid user	0.1	0.1	0.2	0.4	-0.0
Basal metabolic rate	0.1	0.7	1.4	1.2	-0.0
Arm fat-free mass (left)	0.1	0.6	1.2	1.1	-0.1
Age started oral contraceptive pill	0.1	0.1	0.1	0.4	-0.3
Pack years of smoking	0.1	0.2	0.2	-0.3	0.4
Impedance of whole body	0.1	0.7	1.3	-1.1	-0.4
Arm predicted mass (left)	0.1	0.4	0.8	0.9	0.2
Crohns Disease (2012)	0.0	0.1	0.1	0.1	-0.3
Primary Biliary Cirrhosis	0.0	0.0	0.0	-0.1	-0.2
Height	0.0	0.3	0.4	-0.6	-0.5
Smoking Status	0.0	0.1	0.2	0.0	0.4
Allergy or Eczema	0.0	0.1	0.1	-0.3	-0.2
Hair Pigment	0.0	0.4	0.4	-0.6	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.0	-0.1	-0.1
Taking other prescription medications	0.0	0.0	0.0	-0.2	-0.2
Hearing difficulty/problems with background noise	0.0	0.1	0.1	-0.3	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.0	0.1	0.0	-0.3
Pain all over the body in last month	0.0	0.0	0.0	0.1	0.2
Weight	0.0	0.1	0.2	-0.3	-0.4
Hip circumference	0.0	0.1	0.2	0.4	0.1
Time employed in main current job	0.0	0.0	0.0	-0.1	-0.1
Worrier / anxious feelings	0.0	0.0	0.0	0.0	0.1
Depression (self-reported)	0.0	0.0	0.1	-0.2	0.2
Pulse wave Arterial Stiffness index	0.0	0.1	0.1	0.1	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.1	-0.3	-0.0
Pulse wave peak to peak time	0.0	0.0	0.0	-0.2	0.2
Comparative height size at age 10	0.0	0.0	0.0	-0.2	0.2
Knee pain experienced in last month	0.0	0.0	0.0	0.2	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.1	0.1	0.3	0.0
Commuting to job workplace: Public transport	0.0	0.0	0.0	-0.1	0.2
Medication: Atorvastatin	0.0	0.1	0.1	-0.3	-0.1
Basal cell carcinoma (self-reported)	0.0	0.0	0.1	-0.3	-0.1

Hub : Genes

ABCA12

Models

Trait associations