Hub : Traits :

Chronotype (morning person)

392 significantly associated models · 153 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 7135268 8695522 3 2 5.8e-25 4.6e-24 1.0e+00 100 VAMP3
2 1 15119708 16539813 1 1 2.2e-07 1.3e-07 9.3e-02 90 CASP9
3 1 19293249 22200998 4 2 5.5e-12 8.3e-12 8.8e-01 100 HP1BP3 HTR6
4 1 37270283 38679381 1 1 1.9e-07 1.0e-07 2.1e-01 95 MEAF6
5 1 92608852 94120642 1 1 9.8e-08 9.0e-08 7.2e-02 89 FAM69A
6 1 109126153 110834259 3 2 3.0e-10 5.7e-12 NaN NaN AMIGO1 GNAI3
7 1 114417843 115823387 1 1 4.2e-09 1.9e-08 2.2e-02 83 BCAS2
8 1 149672809 151659071 15 6 3.7e-16 6.3e-15 1.0e+00 100 ANXA9 HORMAD1 RP11-54A4.2 TARS2
9 1 181669986 183058898 1 1 3.1e-08 1.2e-39 3.5e-33 17 GLUL
10 2 43844833 45285952 1 1 5.7e-09 1.7e-11 3.0e-04 71 PREPL
11 2 48072855 49519654 1 1 3.7e-08 2.9e-09 3.9e-07 27 STON1
12 2 60707588 62107632 1 1 1.6e-07 2.5e-10 2.9e-04 67 AHSA2
13 2 197560575 200117777 4 1 5.0e-09 1.1e-11 2.9e-04 72 PLCL1
14 2 238347584 239996179 3 2 8.5e-19 3.9e-25 7.0e-07 77 KLHL30 TRAF3IP1
15 3 22551223 24327558 1 1 1.3e-07 1.5e-08 3.3e-03 73 UBE2E2
16 3 48012797 51320800 16 8 1.1e-14 9.2e-12 NaN NaN BSN CYB561D2 HYAL1 RASSF1 SEMA3F U73166.2
17 4 305291 2058475 5 1 1.9e-13 2.9e-08 6.1e-02 89 UVSSA
18 4 82578407 84048087 2 2 1.0e-08 5.0e-11 2.1e-03 78 HNRNPD HNRNPDL
19 5 86867897 88427942 1 1 2.5e-09 1.2e-09 4.5e-06 43 TMEM161B-AS1
20 6 41058968 42450682 2 2 8.8e-09 4.2e-10 6.5e-08 25 PRICKLE4 TOMM6
21 6 152608067 154022718 2 2 7.5e-09 2.5e-19 4.8e-13 35 MTRF1L RP1-101K10.6
22 7 49817957 51215365 1 1 6.1e-08 5.4e-11 1.0e-04 65 FIGNL1
23 7 101330734 103489729 13 15 1.5e-13 2.8e-14 NaN NaN AC093668.2 ARMC10 LRRC17 LRWD1 NAPEPLD POLR2J3 PRKRIP1 RASA4 RP11-514P8.6 SPDYE6
24 7 148552623 150009838 1 1 4.0e-07 3.7e-05 2.3e-02 70 ZNF767
25 8 101232701 102664291 1 1 2.7e-10 1.2e-09 6.8e-01 100 YWHAZ
26 9 85899677 87315117 1 1 1.5e-08 3.6e-09 1.0e+00 100 RMI1
27 9 126421143 127872298 1 1 6.0e-08 1.0e-09 5.8e-09 9 PSMB7
28 9 131169528 132569553 2 1 9.5e-08 5.2e-10 5.8e-06 47 RP11-247A12.1
29 9 138605924 141054761 4 2 6.2e-10 5.8e-08 6.1e-02 88 MRPL41 SDCCAG3
30 10 103807817 105275242 1 1 2.3e-07 3.2e-06 5.6e-01 98 C10orf26
31 10 122989048 124407934 1 2 1.9e-07 5.0e-08 1.2e-03 65 RP11-500G22.2
32 11 29369115 31288160 2 1 5.1e-09 2.5e-09 7.2e-03 80 MPPED2
33 11 46578400 48303325 3 1 7.3e-15 1.1e-07 4.6e-01 98 MADD
34 11 56716782 58178587 2 1 5.6e-08 7.7e-10 2.2e-06 41 AP000662.4
35 11 65151449 66992232 5 2 6.2e-08 2.5e-07 9.3e-02 89 CTD-3074O7.5 PACS1
36 12 32201369 34826574 3 2 1.8e-19 1.1e-25 9.7e-02 98 ALG10 SYT10
37 12 38353816 39998144 2 2 3.9e-22 4.4e-26 3.0e-03 92 CPNE8 RP11-396F22.1
38 12 106675236 108179234 2 2 1.6e-07 1.8e-08 3.8e-03 74 CRY1 MTERFD3
39 12 111385296 113517494 4 1 4.6e-08 5.3e-09 3.5e-02 87 HECTD4
40 12 120242845 121660787 1 1 2.8e-07 3.4e-07 4.4e-03 69 COQ5
41 13 76867667 78295338 2 1 2.8e-16 3.5e-17 1.0e+00 100 CLN5
42 13 93183161 95758325 1 1 9.5e-09 1.2e-08 1.0e+00 100 GPC6
43 14 60517036 62134085 1 1 1.1e-07 9.4e-06 1.9e-02 72 MNAT1
44 14 73724767 75366447 2 1 2.3e-07 5.7e-07 1.6e-01 92 COQ6
45 16 52828325 54235440 1 1 2.7e-07 1.5e-20 9.0e-15 30 AKTIP
46 16 55697964 57157206 1 1 1.1e-08 1.1e-15 3.1e-10 38 AMFR
47 16 71380320 72800567 1 1 4.2e-08 8.7e-10 5.4e-03 79 TXNL4B
48 17 7379650 8823768 2 1 3.6e-15 2.8e-15 1.0e+00 100 TMEM107
49 17 33204020 35123256 4 1 1.4e-10 7.2e-09 1.0e+00 100 AP2B1
50 17 45337417 46721406 1 1 1.1e-07 1.4e-06 4.1e-01 97 RP11-6N17.6
51 17 55903829 57989860 5 1 1.2e-08 5.5e-08 1.7e-01 94 TRIM37
52 17 60399470 62212520 2 1 5.0e-08 4.3e-09 1.1e-03 69 CYB561
53 18 52750469 54144903 1 1 8.9e-11 1.4e-08 2.5e-02 84 RP11-397A16.2
54 18 56118999 57521875 1 1 1.4e-12 3.6e-16 5.3e-05 75 SEC11C
55 19 17412366 18811966 1 1 4.7e-08 4.3e-08 7.9e-04 62 ARRDC2
56 19 45313715 47696626 2 2 7.9e-08 5.5e-08 2.6e-02 83 PNMAL2 PPM1N
57 19 58244898 59095126 2 1 2.0e-07 2.1e-07 1.0e+00 100 CTD-2619J13.17
58 22 41498627 43226599 3 1 1.0e-08 1.0e-09 2.2e-07 28 SLC25A5P1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 1.68 6 2 6.1 -0.64 1.2e-01 AHSA2 HORMAD1 HYAL1 PLCL1 SDCCAG3 SEMA3F
Irritable Bowel Disease (IBD) 2.01 6 5 15.2 -0.94 1.5e-03 AHSA2 ANXA9 HORMAD1 HYAL1 SDCCAG3 SEMA3F
Ulcerative Colitis (UC) 2.13 5 1 3.0 -0.96 2.9e-03 AHSA2 HORMAD1 HYAL1 SDCCAG3 SEMA3F
Reaction Time 1.97 4 2 6.1 0.48 5.2e-01 ALG10 HECTD4 PREPL RMI1
Verbal and Numeric Reasoning (VNR) 1.72 6 3 9.1 0.19 6.8e-01 HYAL1 RP11-247A12.1 RP11-6N17.6 SEMA3F SLC25A5P1 TRIM37
Breast Cancer 1.34 3 1 3.0 0.00 1.0e+00 AKTIP LRRC17 RASA4
Ovarian Cancer 0.93 1 0 0.0 0.00 1.0e+00 RP11-6N17.6
Prostate Cancer 1.37 1 0 0.0 0.00 1.0e+00 RP11-6N17.6
Age at First Birth 1.79 2 1 3.0 0.00 1.0e+00 HYAL1 SEMA3F
Bipolar Disorder 2.07 3 0 0.0 0.00 1.0e+00 CTD-3074O7.5 PACS1 RP1-101K10.6
Body Mass Index (BMI) (2010) 1.98 1 1 3.0 0.00 1.0e+00 AKTIP
Coronary Artery Disease (CAD) 1.21 2 0 0.0 0.00 1.0e+00 HECTD4 HORMAD1
Crohns Disease (2012) 1.57 2 0 0.0 0.00 1.0e+00 PLCL1 SEMA3F
HDL Cholesterol 1.14 1 1 3.0 0.00 1.0e+00 MADD
LDL Cholesterol 1.63 3 1 3.0 0.00 1.0e+00 AMIGO1 GNAI3 HECTD4
Neuroticism 1.71 1 0 0.0 0.00 1.0e+00 U73166.2
Primary Biliary Cirrhosis 1.17 1 0 0.0 0.00 1.0e+00 HECTD4
Schizophrenia 1.35 4 0 0.0 -0.53 4.7e-01 C10orf26 PLCL1 RP11-397A16.2 TMEM161B-AS1
Ulcerative Colitis 2.59 4 1 3.0 0.97 1.6e-03 HYAL1 POLR2J3 SDCCAG3 SEMA3F
Blood Eosinophil Count 1.64 17 10 30.3 -0.07 7.9e-01 AHSA2 ANXA9 CYB561D2 HECTD4 HNRNPDL HORMAD1 HP1BP3 HYAL1 LRWD1 PSMB7 RASSF1 RMI1 RP11-54A4.2 SDCCAG3 SEMA3F TARS2 ZNF767
Blood Platelet Count 1.07 18 13 39.4 0.14 5.6e-01 AP000662.4 AP2B1 COQ6 CTD-2619J13.17 CYB561D2 HNRNPD HORMAD1 PPM1N RASSF1 RMI1 RP11-247A12.1 RP11-397A16.2 RP11-6N17.6 SLC25A5P1 TARS2 TMEM161B-AS1 U73166.2 YWHAZ
Blood Red Count 3.70 18 15 45.5 -0.39 9.8e-02 BCAS2 CTD-2619J13.17 CTD-3074O7.5 CYB561D2 FAM69A FIGNL1 HECTD4 HP1BP3 MEAF6 PLCL1 PPM1N PRICKLE4 RASSF1 RP11-247A12.1 RP11-6N17.6 TMEM107 TOMM6 UBE2E2
Blood White Count 1.59 15 7 21.2 0.04 8.8e-01 AHSA2 CTD-2619J13.17 FAM69A HECTD4 HNRNPDL HTR6 HYAL1 PLCL1 RMI1 RP1-101K10.6 RP11-54A4.2 RP11-6N17.6 SDCCAG3 SEMA3F TARS2
Heel T-Score 1.13 12 6 18.2 -0.63 1.1e-02 ANXA9 AP000662.4 BSN GPC6 HORMAD1 PSMB7 RASSF1 RMI1 RP11-500G22.2 SEMA3F TRAF3IP1 UVSSA
BMI 2.28 24 8 24.2 -0.03 8.9e-01 AKTIP AMFR ARRDC2 CASP9 CTD-3074O7.5 CYB561D2 FAM69A FIGNL1 GNAI3 HECTD4 HORMAD1 HYAL1 MADD MPPED2 MTRF1L PLCL1 PPM1N PSMB7 RP11-54A4.2 SEMA3F SLC25A5P1 TMEM161B-AS1 VAMP3 YWHAZ
Height 1.16 28 22 66.7 -0.03 8.8e-01 ANXA9 CRY1 CTD-3074O7.5 CYB561D2 FAM69A HECTD4 HNRNPD HP1BP3 MNAT1 MPPED2 PNMAL2 POLR2J3 PREPL PRICKLE4 RASSF1 RMI1 RP11-397A16.2 RP11-500G22.2 RP11-54A4.2 RP11-6N17.6 SDCCAG3 TMEM107 TOMM6 TRAF3IP1 TXNL4B U73166.2 UBE2E2 UVSSA
Waist Hip Ratio (WHR) 1.33 11 4 12.1 -0.56 5.7e-02 ALG10 ANXA9 BCAS2 CYB561D2 MNAT1 PRICKLE4 RASSF1 RP11-397A16.2 U73166.2 UVSSA YWHAZ
Systolic Blood Pressure 1.06 8 4 12.1 0.15 7.2e-01 AP000662.4 C10orf26 CASP9 HECTD4 MADD MTRF1L PSMB7 RP11-6N17.6
Smoking Status 1.53 5 0 0.0 0.03 9.6e-01 BSN COQ5 PRICKLE4 SLC25A5P1 TMEM161B-AS1
Allergy or Eczema 1.55 4 1 3.0 -0.52 4.8e-01 AHSA2 CTD-3074O7.5 FAM69A PLCL1
Cardiovascular Disease 0.98 5 2 6.1 0.56 3.2e-01 AHSA2 HECTD4 MADD PLCL1 TMEM161B-AS1
Hypothyroidism (self reported) 1.23 2 1 3.0 0.00 1.0e+00 HECTD4 PSMB7
Respiratory disease 1.35 4 0 0.0 -0.97 2.7e-02 HYAL1 RP11-247A12.1 SEMA3F TARS2
Type 2 Diabetes (T2D) 2.31 7 2 6.1 -0.66 1.0e-01 AKTIP NAPEPLD POLR2J3 PPM1N PRKRIP1 RASA4 RP11-514P8.6
Lung FEV1/FVC ratio 0.97 8 4 12.1 0.10 8.1e-01 AHSA2 AP000662.4 FAM69A HNRNPD PPM1N RP11-247A12.1 TARS2 TRAF3IP1
Lung FVC 1.66 14 7 21.2 -0.23 3.8e-01 ANXA9 CYB561D2 HORMAD1 HYAL1 MNAT1 PNMAL2 PRICKLE4 RASSF1 RP11-54A4.2 SDCCAG3 SEMA3F SLC25A5P1 TRAF3IP1 U73166.2
Neuroticism 1.63 7 2 6.1 -0.99 2.2e-06 AP000662.4 CYB561D2 HP1BP3 HYAL1 RASSF1 SEMA3F U73166.2
Hair Pigment 0.14 6 3 9.1 0.08 8.8e-01 HECTD4 MADD MNAT1 RP11-6N17.6 SDCCAG3 TRIM37
Tanning 0.25 3 2 6.1 0.00 1.0e+00 ANXA9 HORMAD1 TMEM161B-AS1
Hand grip strength (left) 1.44 5 0 0.0 0.74 9.4e-02 ANXA9 HORMAD1 RP11-54A4.2 RP11-6N17.6 UVSSA
Number of treatments/medications taken 1.67 2 1 3.0 0.00 1.0e+00 HYAL1 SEMA3F
Sensitivity / hurt feelings 1.41 1 0 0.0 0.00 1.0e+00 RMI1
Frequency of depressed mood in last 2 weeks 2.01 4 0 0.0 1.00 1.1e-03 AP000662.4 HYAL1 RASSF1 U73166.2
Relative age of first facial hair 1.90 8 2 6.1 0.58 1.0e-01 AHSA2 BSN CTD-2619J13.17 CYB561D2 HYAL1 PRICKLE4 RASSF1 TOMM6
Other serious medical condition/disability diagnosed by doctor 1.44 1 0 0.0 0.00 1.0e+00 PRICKLE4
Ever used hormone-replacement therapy (HRT) 1.12 1 0 0.0 0.00 1.0e+00 PSMB7
Ever had hysterectomy (womb removed) 1.21 1 0 0.0 0.00 1.0e+00 SEMA3F
Systolic blood pressure, automated reading 0.93 3 1 3.0 0.00 1.0e+00 C10orf26 CASP9 HECTD4
Medication: Metformin 1.50 1 1 3.0 0.00 1.0e+00 PPM1N
Pack years adult smoking proportion 1.44 1 0 0.0 0.00 1.0e+00 CYB561
Impedance of leg (right) 2.36 14 10 30.3 0.59 2.0e-02 AKTIP CTD-3074O7.5 CYB561D2 HNRNPD LRWD1 MADD MPPED2 PLCL1 RASSF1 RP11-6N17.6 SEMA3F TARS2 U73166.2 YWHAZ
Leg fat-free mass (left) 1.70 17 6 18.2 0.06 8.0e-01 AKTIP ANXA9 FIGNL1 HECTD4 HYAL1 LRRC17 MADD MNAT1 MPPED2 PLCL1 PNMAL2 RP11-500G22.2 SEMA3F SLC25A5P1 TMEM107 UVSSA YWHAZ
Trunk fat percentage 1.70 10 4 12.1 -0.01 9.7e-01 AKTIP GNAI3 HNRNPD HORMAD1 HYAL1 MADD MPPED2 POLR2J3 SEMA3F TMEM161B-AS1
Hand grip strength (right) 1.49 5 0 0.0 0.68 2.1e-01 ANXA9 CYB561 LRWD1 RP11-54A4.2 UVSSA
Fed-up feelings 1.36 3 0 0.0 1.00 1.5e-03 HECTD4 HYAL1 SEMA3F
Frequency of unenthusiasm / disinterest in last 2 weeks 1.94 5 0 0.0 1.00 1.2e-04 AP000662.4 CYB561D2 HYAL1 RASSF1 U73166.2
Relative age voice broke 1.43 1 0 0.0 0.00 1.0e+00 CTD-2619J13.17
Taking other prescription medications 2.22 3 2 6.1 0.99 8.5e-03 HYAL1 RASSF1 SEMA3F
Age when periods started (menarche) 2.09 9 5 15.2 0.51 1.1e-01 AKTIP BSN CTD-2619J13.17 CYB561D2 HYAL1 MADD PRICKLE4 RP11-500G22.2 SEMA3F
Heel bone mineral density (BMD) T-score, automated (left) 1.10 3 1 3.0 0.27 7.3e-01 BSN RP11-500G22.2 UVSSA
Tinnitus: Yes, but not now, but have in the past 1.97 1 0 0.0 0.00 1.0e+00 POLR2J3
Qualifications: CSEs or equivalent 1.31 1 0 0.0 0.00 1.0e+00 HORMAD1
High blood pressure 0.83 4 1 3.0 0.25 7.5e-01 AHSA2 GNAI3 HECTD4 MADD
Hayfever, allergic rhinitis or eczema 1.48 3 1 3.0 0.00 1.0e+00 AHSA2 CYB561D2 PLCL1
Supplements: Glucosamine 1.38 1 0 0.0 0.00 1.0e+00 TARS2
Medication: Atenolol 1.04 1 0 0.0 0.00 1.0e+00 HECTD4
Medication: Levothyroxine sodium 1.23 1 1 3.0 0.00 1.0e+00 HECTD4
Sitting height 0.96 13 4 12.1 0.38 1.8e-01 ARMC10 CRY1 FAM69A LRRC17 MNAT1 MPPED2 NAPEPLD POLR2J3 RMI1 RP11-514P8.6 SDCCAG3 TMEM107 UBE2E2
Body mass index (BMI) 2.09 10 7 21.2 0.14 6.8e-01 AKTIP CTD-3074O7.5 GNAI3 HECTD4 HYAL1 MADD MPPED2 PLCL1 SEMA3F YWHAZ
Impedance of leg (left) 2.19 14 9 27.3 0.49 6.3e-02 AKTIP CTD-3074O7.5 CYB561D2 HNRNPD MADD MPPED2 PLCL1 PNMAL2 RASSF1 RP11-6N17.6 SEMA3F TARS2 U73166.2 YWHAZ
Leg predicted mass (left) 1.71 17 5 15.2 0.06 8.0e-01 AKTIP ANXA9 FIGNL1 HECTD4 HYAL1 LRRC17 MADD MNAT1 MPPED2 PLCL1 PNMAL2 RP11-500G22.2 SEMA3F SLC25A5P1 TMEM107 UVSSA YWHAZ
Trunk fat mass 1.85 13 5 15.2 0.09 7.7e-01 AKTIP FIGNL1 GNAI3 HECTD4 HNRNPD HORMAD1 HYAL1 MADD MPPED2 POLR2J3 SEMA3F SLC25A5P1 TMEM161B-AS1
Waist circumference 1.83 9 4 12.1 0.24 5.0e-01 AKTIP FIGNL1 GNAI3 HECTD4 HYAL1 MADD MPPED2 MTRF1L SEMA3F
Number of incorrect matches in round 1.12 1 0 0.0 0.00 1.0e+00 HP1BP3
Past tobacco smoking 1.34 1 0 0.0 0.00 1.0e+00 TMEM161B-AS1
Alcohol usually taken with meals 1.53 3 0 0.0 0.00 1.0e+00 AP000662.4 PRICKLE4 RMI1
Nervous feelings 1.76 5 1 3.0 0.68 1.3e-01 CYB561D2 MNAT1 RASSF1 U73166.2 UVSSA
Frequency of tenseness / restlessness in last 2 weeks 1.50 2 0 0.0 0.00 1.0e+00 HYAL1 SEMA3F
Forced vital capacity (FVC) 1.10 5 2 6.1 0.38 4.0e-01 ANXA9 CRY1 HORMAD1 RP11-397A16.2 TXNL4B
Heel bone mineral density (BMD) T-score, automated (right) 1.31 3 1 3.0 0.36 6.4e-01 BSN RP11-500G22.2 UVSSA
Ever unenthusiastic/disinterested for a whole week 2.52 6 0 0.0 0.99 9.4e-05 BSN CYB561D2 HYAL1 RASSF1 SEMA3F U73166.2
Qualifications: None of the above 1.61 5 1 3.0 0.73 9.8e-02 AP000662.4 BSN COQ6 HYAL1 SEMA3F
Allergy 1.45 4 1 3.0 -0.61 3.9e-01 AHSA2 CTD-3074O7.5 CYB561D2 PLCL1
Diabetes (self-reported) 1.96 2 1 3.0 0.00 1.0e+00 NAPEPLD PPM1N
Hayfever/allergic rhinitis (self-reported) 1.60 1 1 3.0 0.00 1.0e+00 PLCL1
Medication: Simvastatin 1.33 1 1 3.0 0.00 1.0e+00 AMIGO1
Fluid intelligence score 1.63 5 2 6.1 -0.62 1.9e-01 AHSA2 HYAL1 RP11-247A12.1 SEMA3F TRIM37
Neuroticism score 1.93 7 4 12.1 0.99 1.7e-06 AP000662.4 CYB561D2 HP1BP3 HYAL1 RASSF1 SEMA3F U73166.2
Weight 1.95 16 6 18.2 0.15 5.6e-01 AKTIP FIGNL1 GNAI3 GPC6 HECTD4 HYAL1 MADD MNAT1 MPPED2 NAPEPLD PLCL1 POLR2J3 RP11-500G22.2 SEMA3F SLC25A5P1 YWHAZ
Impedance of arm (right) 2.21 16 9 27.3 0.01 9.5e-01 AKTIP CYB561D2 HNRNPD HYAL1 LRRC17 LRWD1 NAPEPLD PLCL1 PSMB7 RASA4 RASSF1 RMI1 RP11-6N17.6 SEMA3F U73166.2 YWHAZ
Arm fat percentage (right) 1.78 10 5 15.2 0.06 8.5e-01 AKTIP CTD-3074O7.5 GNAI3 HORMAD1 HYAL1 MADD MPPED2 POLR2J3 SEMA3F TMEM161B-AS1
Trunk fat-free mass 1.58 20 8 24.2 0.24 2.9e-01 AKTIP CRY1 FIGNL1 GPC6 HECTD4 HYAL1 LRRC17 MNAT1 MPPED2 NAPEPLD PLCL1 PNMAL2 POLR2J3 RASA4 RP11-500G22.2 SDCCAG3 SEMA3F SLC25A5P1 TMEM107 UVSSA
Hip circumference 1.83 9 7 21.2 0.08 8.3e-01 AKTIP AMFR FIGNL1 GNAI3 HECTD4 MADD MPPED2 SEMA3F YWHAZ
Alcohol intake versus 10 years previously 1.99 2 2 6.1 0.00 1.0e+00 HYAL1 SEMA3F
Worrier / anxious feelings 1.81 5 1 3.0 0.70 1.2e-01 CYB561 CYB561D2 HP1BP3 RASSF1 U73166.2
Frequency of tiredness / lethargy in last 2 weeks 1.80 3 0 0.0 0.00 1.0e+00 AP000662.4 BSN HECTD4
Falls in the last year 1.33 1 0 0.0 0.00 1.0e+00 MPPED2
Forced expiratory volume in 1-second (FEV1) 1.02 2 1 3.0 0.00 1.0e+00 ANXA9 HORMAD1
Pulse rate 1.96 3 2 6.1 0.00 1.0e+00 ALG10 BSN CPNE8
Qualifications: A levels/AS levels or equivalent 1.70 2 2 6.1 0.00 1.0e+00 HYAL1 SEMA3F
Mouth/teeth dental problems: Dentures 1.20 1 0 0.0 0.00 1.0e+00 SEMA3F
Asthma 1.40 3 0 0.0 0.00 1.0e+00 PLCL1 RP11-247A12.1 SEMA3F
Medication: Ibuprofen (e.g. Nurofen) 1.11 2 0 0.0 0.00 1.0e+00 HECTD4 TARS2
Medication: Cholesterol lowering 1.43 1 1 3.0 0.00 1.0e+00 AMIGO1
Prospective memory result 1.89 1 0 0.0 0.00 1.0e+00 MADD
Forced expiratory volume in 1-second (FEV1), Best measure 0.91 2 1 3.0 0.00 1.0e+00 ANXA9 HORMAD1
Impedance of arm (left) 2.14 15 8 24.2 -0.06 8.2e-01 AKTIP CYB561D2 HNRNPD HYAL1 LRRC17 NAPEPLD PLCL1 PSMB7 RASA4 RASSF1 RMI1 RP11-396F22.1 SEMA3F U73166.2 YWHAZ
Arm fat mass (right) 2.02 11 6 18.2 0.25 4.4e-01 AKTIP FIGNL1 GNAI3 HECTD4 HYAL1 MADD MPPED2 SEMA3F SLC25A5P1 TMEM161B-AS1 YWHAZ
Trunk predicted mass 1.58 20 8 24.2 0.24 3.0e-01 AKTIP CRY1 FIGNL1 GPC6 HECTD4 HYAL1 LRRC17 MNAT1 MPPED2 NAPEPLD PLCL1 PNMAL2 POLR2J3 RASA4 RP11-500G22.2 SDCCAG3 SEMA3F SLC25A5P1 TMEM107 UVSSA
Standing height 1.20 21 13 39.4 0.05 8.3e-01 ANXA9 CRY1 CTD-3074O7.5 CYB561D2 FAM69A HECTD4 HNRNPD HP1BP3 MNAT1 MPPED2 POLR2J3 RASSF1 RMI1 RP11-397A16.2 RP11-500G22.2 RP11-6N17.6 SDCCAG3 TMEM107 TOMM6 TRAF3IP1 UVSSA
Tense / 'highly strung' 1.92 4 3 9.1 1.00 2.3e-04 CYB561D2 HYAL1 RASSF1 U73166.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.95 1 0 0.0 0.00 1.0e+00 CTD-3074O7.5
Hair/balding pattern: Pattern 4 0.70 1 0 0.0 0.00 1.0e+00 RMI1
Birth weight of first child 1.36 2 0 0.0 0.00 1.0e+00 C10orf26 HECTD4
Peak expiratory flow (PEF) 1.26 3 0 0.0 0.00 1.0e+00 ANXA9 RP11-54A4.2 TARS2
Ever highly irritable/argumentative for 2 days 1.89 3 2 6.1 0.00 1.0e+00 HYAL1 RASSF1 SEMA3F
Qualifications: O levels/GCSEs or equivalent 1.15 1 0 0.0 0.00 1.0e+00 PRICKLE4
Medication: Paracetamol 1.09 1 0 0.0 0.00 1.0e+00 BSN
Headache pain in last month 1.51 3 2 6.1 0.00 1.0e+00 HECTD4 RP11-54A4.2 TARS2
Medication for cholesterol, blood pressure or diabetes 1.54 3 0 0.0 0.00 1.0e+00 AKTIP AMIGO1 PPM1N
Hypothyroidism/myxoedema (self-reported) 1.15 1 1 3.0 0.00 1.0e+00 HECTD4
Medication: Amlodipine 1.09 2 0 0.0 0.00 1.0e+00 AHSA2 TRIM37
Birth weight 1.63 2 1 3.0 0.00 1.0e+00 C10orf26 TARS2
Forced vital capacity (FVC), Best measure 1.08 3 2 6.1 0.99 1.4e-02 ANXA9 CRY1 HORMAD1
Body fat percentage 1.75 8 5 15.2 0.05 8.9e-01 AKTIP GNAI3 HNRNPD HORMAD1 HYAL1 MADD POLR2J3 SEMA3F
Leg fat percentage (right) 1.82 7 4 12.1 0.46 2.5e-01 AKTIP GNAI3 HECTD4 HNRNPD HYAL1 POLR2J3 SEMA3F
Arm fat-free mass (right) 1.73 17 7 21.2 0.16 5.4e-01 AKTIP FIGNL1 HECTD4 HYAL1 LRRC17 MNAT1 MPPED2 NAPEPLD PLCL1 PNMAL2 PSMB7 RP11-500G22.2 SEMA3F SLC25A5P1 TMEM107 UVSSA YWHAZ
Exposure to tobacco smoke outside home 1.43 1 0 0.0 0.00 1.0e+00 GNAI3
Comparative body size at age 10 2.67 10 4 12.1 -0.65 2.9e-02 AKTIP ALG10 CYB561D2 GNAI3 HNRNPD MADD NAPEPLD PLCL1 RASSF1 U73166.2
Number of full brothers 1.25 1 0 0.0 0.00 1.0e+00 RP11-397A16.2
Worry too long after embarrassment 1.67 2 1 3.0 0.00 1.0e+00 AP000662.4 HP1BP3
Wheeze or whistling in the chest in last year 1.57 3 1 3.0 0.99 5.1e-03 HYAL1 MTRF1L SEMA3F
Age at first live birth 1.34 2 2 6.1 0.00 1.0e+00 HYAL1 SEMA3F
Health satisfaction 1.42 1 0 0.0 0.00 1.0e+00 RASSF1
Qualifications: College or University degree 2.15 9 2 6.1 -0.30 4.0e-01 AP000662.4 BSN HYAL1 PACS1 RP11-54A4.2 SEMA3F SLC25A5P1 TMEM161B-AS1 TXNL4B
Medication for pain relief, constipation, heartburn 1.09 1 0 0.0 0.00 1.0e+00 TARS2
Migraine (self-reported) 1.23 1 0 0.0 0.00 1.0e+00 RP11-54A4.2
Medication: Omeprazole 1.62 1 0 0.0 0.00 1.0e+00 TARS2
Mean time to correctly identify matches 1.98 4 2 6.1 -0.50 5.0e-01 ALG10 HECTD4 PREPL RMI1
Heart disease (mother) 0.84 1 0 0.0 0.00 1.0e+00 HECTD4
Whole body fat mass 1.94 10 6 18.2 0.32 3.4e-01 AKTIP FIGNL1 GNAI3 HECTD4 HYAL1 MADD MPPED2 POLR2J3 SEMA3F YWHAZ
Leg fat mass (right) 2.10 9 5 15.2 0.31 3.8e-01 AKTIP FIGNL1 GNAI3 HECTD4 HYAL1 MADD MPPED2 SEMA3F YWHAZ
Arm predicted mass (right) 1.77 17 9 27.3 0.16 5.1e-01 AKTIP FIGNL1 HECTD4 HYAL1 LRRC17 MNAT1 MPPED2 NAPEPLD PLCL1 PNMAL2 PSMB7 RP11-500G22.2 SEMA3F SLC25A5P1 TMEM107 UVSSA YWHAZ
Pulse rate, automated reading 2.15 13 6 18.2 -0.22 4.5e-01 ALG10 AP000662.4 BSN CPNE8 CYB561D2 HNRNPD HNRNPDL PRICKLE4 RASSF1 RP11-396F22.1 SYT10 TMEM161B-AS1 UVSSA
Alcohol intake frequency. 1.28 4 2 6.1 0.55 4.5e-01 AP000662.4 HYAL1 SEMA3F TXNL4B
Comparative height size at age 10 0.99 12 6 18.2 -0.29 3.6e-01 ANXA9 CTD-3074O7.5 HECTD4 HNRNPD HP1BP3 MNAT1 MPPED2 RMI1 SDCCAG3 TMEM107 TRAF3IP1 UVSSA
Suffer from 'nerves' 1.15 1 1 3.0 0.00 1.0e+00 MADD
Overall health rating 1.94 7 4 12.1 0.75 3.3e-02 AP000662.4 AP2B1 CYB561D2 HYAL1 PLCL1 RASSF1 SEMA3F
Age at last live birth 1.80 2 2 6.1 0.00 1.0e+00 HYAL1 SEMA3F
Family relationship satisfaction 1.36 1 0 0.0 0.00 1.0e+00 AMIGO1
Leg pain on walking 1.26 1 0 0.0 0.00 1.0e+00 SEMA3F
Supplements: Vitamin C 1.19 1 0 0.0 0.00 1.0e+00 PRICKLE4
Knee pain experienced in last month 1.12 1 0 0.0 0.00 1.0e+00 SEMA3F
Hypertension (Self-reported) 0.77 4 0 0.0 0.23 7.7e-01 AHSA2 GNAI3 HECTD4 MADD
Illnesses of father: Heart disease 0.94 1 0 0.0 0.00 1.0e+00 GNAI3
Smoking status: Previous 1.43 2 0 0.0 0.00 1.0e+00 HECTD4 TMEM161B-AS1
Forced expiratory volume in 1-second (FEV1), predicted 1.22 2 0 0.0 0.00 1.0e+00 CYB561D2 SDCCAG3
Whole body fat-free mass 1.67 18 8 24.2 0.29 2.1e-01 AKTIP FIGNL1 GPC6 HECTD4 HYAL1 LRRC17 MNAT1 MPPED2 NAPEPLD PLCL1 PNMAL2 POLR2J3 RP11-500G22.2 SEMA3F SLC25A5P1 TMEM107 UVSSA YWHAZ
Leg fat-free mass (right) 1.67 16 6 18.2 -0.03 9.0e-01 AKTIP ANXA9 FIGNL1 HECTD4 LRRC17 MADD MNAT1 MPPED2 PLCL1 PNMAL2 RP11-500G22.2 SEMA3F SLC25A5P1 TMEM107 UVSSA YWHAZ
Arm fat percentage (left) 1.79 10 4 12.1 0.04 9.0e-01 AKTIP CTD-3074O7.5 GNAI3 HORMAD1 HYAL1 MADD MPPED2 POLR2J3 SEMA3F TMEM161B-AS1
Average weekly red wine intake 1.68 1 1 3.0 0.00 1.0e+00 AP000662.4
Mood swings 1.41 3 1 3.0 0.00 1.0e+00 AMIGO1 HYAL1 SEMA3F
Ever had bowel cancer screening 1.64 1 1 3.0 0.00 1.0e+00 PRICKLE4
Diabetes diagnosed by doctor 1.90 4 1 3.0 0.51 4.9e-01 AKTIP NAPEPLD POLR2J3 PPM1N
Friendships satisfaction 1.92 2 0 0.0 0.00 1.0e+00 RP11-397A16.2 TARS2
Qualifications: nursing, teaching 1.64 2 0 0.0 0.00 1.0e+00 COQ6 SEMA3F
Mouth/teeth dental problems: Mouth ulcers 1.20 2 0 0.0 0.00 1.0e+00 ANXA9 HORMAD1
Back pain experienced in last month 1.11 1 0 0.0 0.00 1.0e+00 HECTD4
Mineral and other dietary supplements 1.29 1 0 0.0 0.00 1.0e+00 PRICKLE4
Asthma (self-reported) 1.30 3 0 0.0 0.00 1.0e+00 HYAL1 RP11-247A12.1 SEMA3F
Osteoporosis (self-reported) 1.18 1 0 0.0 0.00 1.0e+00 RP11-397A16.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.22 1 0 0.0 0.00 1.0e+00 ANXA9
Whole body water mass 1.66 16 8 24.2 0.12 6.4e-01 AKTIP FIGNL1 GPC6 HECTD4 HYAL1 LRRC17 MNAT1 MPPED2 PLCL1 PNMAL2 RP11-500G22.2 SEMA3F SLC25A5P1 TMEM107 UVSSA YWHAZ
Leg predicted mass (right) 1.67 16 6 18.2 -0.04 8.9e-01 AKTIP ANXA9 FIGNL1 HECTD4 LRRC17 MADD MNAT1 MPPED2 PLCL1 PNMAL2 RP11-500G22.2 SEMA3F SLC25A5P1 TMEM107 UVSSA YWHAZ
Arm fat mass (left) 2.01 11 6 18.2 0.25 4.4e-01 AKTIP FIGNL1 GNAI3 HECTD4 HYAL1 MADD MPPED2 SEMA3F SLC25A5P1 TMEM161B-AS1 YWHAZ
Number of self-reported non-cancer illnesses 1.80 3 0 0.0 0.00 1.0e+00 HP1BP3 HYAL1 SEMA3F
Miserableness 1.60 2 2 6.1 0.00 1.0e+00 HYAL1 SEMA3F
Guilty feelings 1.43 1 0 0.0 0.00 1.0e+00 AP000662.4
Tinnitus: Yes, now most or all of the time 1.29 1 0 0.0 0.00 1.0e+00 RP11-6N17.6
Eye problems/disorders: Glaucoma 1.79 1 0 0.0 0.00 1.0e+00 NAPEPLD
Medication: Blood pressure 0.71 2 0 0.0 0.00 1.0e+00 GNAI3 HECTD4
Pain type(s) experienced in last month: Hip pain 1.09 1 0 0.0 0.00 1.0e+00 TARS2
High cholesterol (Self-reported) 1.72 2 1 3.0 0.00 1.0e+00 AMIGO1 RP11-6N17.6
Medication: Paracetamol 1.05 1 0 0.0 0.00 1.0e+00 BSN
Ever smoked 1.18 1 0 0.0 0.00 1.0e+00 TMEM161B-AS1
Basal metabolic rate 1.77 18 8 24.2 0.27 2.4e-01 AKTIP FIGNL1 GPC6 HECTD4 HYAL1 LRRC17 MNAT1 MPPED2 NAPEPLD PLCL1 PNMAL2 POLR2J3 RP11-500G22.2 SEMA3F SLC25A5P1 TMEM107 UVSSA YWHAZ
Leg fat percentage (left) 1.74 6 4 12.1 0.25 5.9e-01 AKTIP GNAI3 HNRNPD HYAL1 MADD SEMA3F
Arm fat-free mass (left) 1.85 18 8 24.2 0.26 2.7e-01 AKTIP FIGNL1 GPC6 HECTD4 HYAL1 LRRC17 MNAT1 MPPED2 NAPEPLD PLCL1 PNMAL2 PSMB7 RP11-500G22.2 SEMA3F SLC25A5P1 TMEM107 UVSSA YWHAZ
Number of operations (self-reported) 1.69 4 0 0.0 0.99 5.5e-03 BSN HYAL1 PSMB7 SEMA3F
Average weekly beer plus cider intake 1.88 3 1 3.0 0.62 3.8e-01 HYAL1 PRICKLE4 SEMA3F
Risk taking 1.28 1 0 0.0 0.00 1.0e+00 RP11-397A16.2
Diastolic blood pressure, automated reading 1.02 2 1 3.0 0.00 1.0e+00 HECTD4 SEMA3F
Ever depressed for a whole week 1.42 1 0 0.0 0.00 1.0e+00 BSN
Vascular/heart problems diagnosed by doctor 0.91 6 1 3.0 -0.42 4.1e-01 AHSA2 GNAI3 HECTD4 HP1BP3 MADD PPM1N
Cholesterol lowering medication 1.24 1 0 0.0 0.00 1.0e+00 GNAI3
Medication: Omeprazole (e.g. Zanprol) 1.50 1 0 0.0 0.00 1.0e+00 PRICKLE4
Pain experienced in last month 1.28 1 0 0.0 0.00 1.0e+00 HECTD4
Pack years of smoking 1.56 1 0 0.0 0.00 1.0e+00 CYB561
Impedance of whole body 2.27 16 10 30.3 0.20 4.4e-01 AKTIP CTD-3074O7.5 CYB561D2 HNRNPD LRRC17 MPPED2 PLCL1 PNMAL2 PSMB7 RASSF1 RMI1 RP11-6N17.6 SEMA3F TARS2 U73166.2 YWHAZ
Leg fat mass (left) 2.05 9 6 18.2 0.31 3.8e-01 AKTIP FIGNL1 GNAI3 HECTD4 HYAL1 MADD MPPED2 SEMA3F YWHAZ
Arm predicted mass (left) 1.89 19 8 24.2 0.29 1.9e-01 AKTIP CRY1 FIGNL1 GPC6 HECTD4 HYAL1 LRRC17 MNAT1 MPPED2 NAPEPLD PLCL1 PNMAL2 POLR2J3 PSMB7 RP11-500G22.2 SEMA3F SLC25A5P1 TMEM107 UVSSA

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 12 0.3436 2.42
GTEx Adipose Visceral Omentum 6 0.2946 2.33
GTEx Adrenal Gland 4 0.2745 2.47
GTEx Artery Aorta 11 0.3695 2.39
GTEx Artery Coronary 6 0.5068 2.54
GTEx Artery Tibial 13 0.3459 2.33
GTEx Brain Caudate basal ganglia 3 0.3261 2.26
GTEx Brain Cerebellar Hemisphere 6 0.4030 2.35
GTEx Brain Cerebellum 8 0.4034 2.41
GTEx Brain Cortex 5 0.4836 2.44
GTEx Brain Frontal Cortex BA9 2 0.2162 2.45
GTEx Brain Hippocampus 0 0.0000 2.25
GTEx Brain Hypothalamus 0 0.0000 2.38
GTEx Brain Nucleus accumbens basal ganglia 2 0.2309 2.32
GTEx Brain Putamen basal ganglia 6 0.9615 2.39
GTEx Breast Mammary Tissue 11 0.5570 2.43
GTEx Breast Mammary Tissue (Male) 1 0.0838 2.11
GTEx Breast Mammary Tissue (Female) 8 0.4863 2.35
GTEx Cells EBV-transformed lymphocytes 1 0.0704 2.47
GTEx Cells Transformed fibroblasts 15 0.3573 2.36
GTEx Colon Sigmoid 2 0.1367 2.28
GTEx Colon Transverse 11 0.5327 2.54
GTEx Esophagus Gastroesophageal Junction 4 0.2768 2.39
GTEx Esophagus Mucosa 13 0.3914 2.43
GTEx Esophagus Muscularis 15 0.4641 2.42
GTEx Heart Atrial Appendage 6 0.3797 2.39
GTEx Heart Left Ventricle 10 0.6532 2.41
GTEx Liver 2 0.2789 2.38
GTEx Lung 13 0.4525 2.46
GTEx Muscle Skeletal 12 0.4149 2.44
GTEx Nerve Tibial 16 0.3700 2.36
GTEx Ovary 0 0.0000 2.18
GTEx Pancreas 8 0.4899 2.37
GTEx Pituitary 6 0.5376 2.48
GTEx Prostate 4 0.4796 2.41
GTEx Skin Not Sun Exposed Suprapubic 9 0.3659 2.44
GTEx Skin Sun Exposed Lower leg 11 0.3024 2.39
GTEx Small Intestine Terminal Ileum 2 0.4329 2.51
GTEx Spleen 6 0.4252 2.45
GTEx Stomach 3 0.2062 2.40
GTEx Testis 12 0.3801 2.39
GTEx Thyroid 17 0.4253 2.40
GTEx Uterus 3 0.5291 2.54
GTEx Vagina 0 0.0000 2.12
GTEx Whole Blood 9 0.4523 2.35
METSIM Adipose 8 0.1737 2.13
NTR Blood 7 0.2914 2.29
ROSMAP Brain Pre-frontal Cortex 16 0.3645 2.36
YFS Blood 8 0.1733 2.17
CommonMind Brain Pre-frontal Cortex 14 0.2604 2.30
TCGA Breast Tumor 0 0.0000 2.27
TCGA Breast Normal 11 0.2615 2.01
TCGA Ovarian Tumor 4 0.1368 1.93
TCGA Prostate Tumor 10 0.2893 2.32