Hub : Genes

FOXP4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellum 0.3990 0.1250 0.00420 0.002 NA 0.008 NA 0.004 2.8e-01 NA 1.8e-01 NA 2.4e-01
2 GTEx Esophagus Mucosa 0.2050 0.0590 0.00048 0.149 NA 0.145 NA 0.145 3.6e-10 NA 6.8e-10 NA 6.4e-10
3 GTEx Pancreas 0.1640 0.0640 0.00390 -0.007 NA -0.006 NA -0.006 9.9e-01 NA 6.6e-01 NA 7.7e-01
4 METSIM Adipose 0.0707 0.0225 0.00013 0.007 0.030 0.044 0.034 0.015 2.3e-02 2.1e-05 3.2e-07 6.8e-06 1.9e-03
5 ROSMAP Brain Pre-frontal Cortex 0.0772 0.0315 0.00550 0.022 -0.001 0.017 0.022 0.029 6.3e-04 4.7e-01 2.6e-03 5.8e-04 1.2e-04
6 TCGA Prostate Adenocarcinoma 0.0366 0.0201 0.00530 0.023 0.019 0.018 NA 0.012 1.8e-03 4.2e-03 4.8e-03 NA 1.6e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.1 0.2 0.7 0.9 -0.0 0.0 0.6 0.3 -0.2
Bipolar Disorder or Schizophrenia 0.9 2.2 6.8 1.3 -1.5 0.0 0.8 1.3 -2.6
Depressed Affect (Nagel 2018) 0.7 1.5 5.6 -2.4 -0.2 0.0 0.9 -1.6 0.3
Depression (Nagel 2018) 1.1 1.7 6.8 -1.1 0.9 0.0 0.7 -2.6 0.9
Intelligence (Savage-Jansen 2018) 0.2 0.7 2.8 -0.3 0.7 0.0 1.7 0.4 0.8
Neuroticism (Nagel 2018) 0.8 1.9 4.7 -1.4 -2.2 0.0 0.4 -2.1 -0.6
Schizophrenia (2018) 1.2 2.5 8.4 0.8 -1.9 0.0 0.6 1.4 -2.9
Schizophrenia vs Biploar Disorder 0.7 0.9 1.7 -1.3 -1.0 0.0 -0.5 1.0 -1.3
Worry (Nagel 2018) 0.5 1.2 3.4 -1.3 -1.9 0.0 0.1 -1.3 -0.3
Alzheimer’s Disease (in mother) 0.6 0.7 2.3 0.6 1.5 0.0 -0.5 0.9 -0.4
Alzheimer’s Disease (in father) 0.8 0.9 3.3 -0.1 1.1 0.0 -1.8 0.6 0.7
Alzheimer’s Disease (including proxy) 0.6 0.9 2.5 1.2 0.9 0.0 -1.6 0.8 -0.3
Crohns Disease (2017) 0.3 0.6 1.7 -1.3 -1.1 0.0 0.3 -0.8 -0.3
Irritable Bowel Disease (IBD) 0.1 0.3 1.1 -1.0 -0.5 0.0 -0.2 -0.7 0.3
Ulcerative Colitis (UC) 0.1 0.2 0.6 -0.2 0.5 0.0 -0.4 -0.2 0.8
Major Depression (MDD) 0.2 0.2 0.7 -0.5 -0.4 0.0 0.8 -0.6 0.0
Reaction Time 0.3 0.5 2.6 -0.0 0.3 0.0 -1.6 0.0 0.7
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.7 -0.5 0.2 0.0 0.9 -0.4 0.3
Breast Cancer 0.2 0.6 3.2 0.2 0.2 0.0 -0.5 1.8 0.0
Ovarian Cancer 0.3 0.4 2.2 0.3 -1.5 0.0 -0.1 0.3 -0.5
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.3 0.5 1.0 0.7 0.8 0.0 0.9 -1.0 0.4
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.6 0.9 3.7 -1.9 0.8 0.0 1.0 -0.1 0.3
Coronary Artery Disease (CAD) 1.1 1.3 5.7 -0.8 0.9 0.0 -2.4 -0.8 0.0
Crohns Disease (2012) 0.8 1.3 5.2 0.7 -2.3 0.0 -0.8 -1.1 0.0
Mean Putamen Volume 0.7 0.8 3.9 -0.6 -2.0 0.0 0.2 -0.2 -0.5
Fasting Glucose 0.8 1.0 5.2 0.6 -0.2 0.0 2.3 -0.1 -0.7
HbA1C 0.9 1.0 4.0 -0.5 -0.2 0.0 1.2 2.0 -0.4
HDL Cholesterol 0.5 0.9 3.7 1.9 -0.0 0.0 1.2 0.1 -0.2
LDL Cholesterol 1.3 2.1 10.5 -1.1 -0.8 0.0 -3.2 -0.0 0.1
Lupus 0.8 1.2 5.9 -1.0 0.1 0.0 0.4 -2.4 0.2
Neuroticism (2016) 0.8 1.2 3.8 -0.0 -1.7 0.0 -0.4 -0.5 -1.9
Primary Biliary Cirrhosis 0.2 0.3 1.4 -1.2 -0.1 0.0 -0.2 0.1 0.3
Rheumatoid Arthritis 0.5 0.6 1.9 0.1 -0.5 0.0 1.2 1.4 -0.4
Schizophrenia (2014) 0.6 1.4 5.2 -0.1 -1.4 0.0 0.3 0.9 -2.3
Triglycerides 1.1 1.8 8.7 -2.9 0.4 0.0 -1.3 -0.2 0.4
Type 2 Diabetes (T2D) (2012) 0.3 0.3 1.2 -1.1 0.3 0.0 -0.3 0.7 0.2
Ulcerative Colitis 0.3 0.4 1.5 -0.1 0.3 0.0 -1.2 0.8 0.3
Blood Eosinophil Count 1.1 8.3 21.2 -0.8 4.6 0.0 2.9 0.9 4.3
Blood Platelet Count 0.3 3.3 7.3 -2.1 2.7 0.0 -0.9 -0.6 2.6
Blood Red Count 1.1 10.6 57.0 7.5 1.2 0.0 -0.9 -1.9 0.9
Blood White Count 0.2 1.4 4.9 -2.2 -0.5 0.0 1.6 -0.8 -0.3
Heel T-Score 1.5 11.9 28.1 -1.1 5.3 0.0 -0.2 -3.8 5.3
BMI 0.8 4.9 15.9 -0.6 3.1 0.0 4.0 -0.5 1.7
Height 0.1 1.6 9.2 -3.0 0.3 0.0 0.0 0.4 0.6
Waist Hip Ratio (WHR) 0.3 1.3 6.0 -0.3 0.4 0.0 -2.5 -0.9 0.9
Systolic Blood Pressure 1.1 5.6 14.4 -3.8 3.5 0.0 0.6 0.3 2.6
Smoking Status 0.9 2.1 4.9 0.9 -1.2 0.0 -1.0 2.0 -2.2
Allergy or Eczema 0.4 1.0 2.7 -0.4 -0.1 0.0 1.5 -1.6 0.9
Cardiovascular Disease 0.9 3.0 8.3 -1.8 1.4 0.0 0.9 -2.9 2.0
Hypothyroidism (self reported) 0.5 1.1 2.6 1.6 -0.8 0.0 -1.3 -1.2 -0.0
Respiratory disease 0.7 1.6 5.0 -1.2 1.5 0.0 2.2 0.2 1.0
Type 2 Diabetes (T2D) (2018) 0.4 0.8 3.3 -0.2 0.9 0.0 -0.7 -1.8 0.2
Lung FEV1/FVC ratio 0.4 2.2 7.0 0.8 2.6 0.0 -0.2 0.4 2.3
Lung FVC 0.1 0.7 1.8 0.8 1.4 0.0 0.7 0.3 1.0
Neuroticism 0.5 1.1 4.1 0.5 -2.0 0.0 0.0 -0.9 -1.3
Chronotype (morning person) 4.9 11.4 34.7 -2.0 4.4 0.0 1.2 -3.0 5.9
Hair Pigment 0.1 1.4 4.2 0.7 -1.6 0.0 -0.8 0.9 -2.1
Tanning 0.1 0.8 3.6 -1.9 1.0 0.0 -0.5 -0.2 0.4
Hand grip strength (left) 0.0 0.1 0.3 0.6 0.4 0.0 0.5 -0.1 -0.1
Number of treatments/medications taken 0.1 0.2 0.9 -0.5 -0.1 0.0 0.9 0.2 0.1
Average weekly spirits intake 0.8 1.0 5.0 -0.9 0.6 0.0 2.2 -0.3 0.1
Sensitivity / hurt feelings 0.2 0.3 1.1 -0.0 -0.3 0.0 1.0 -0.8 0.4
Frequency of depressed mood in last 2 weeks 0.3 0.5 2.1 -0.6 0.3 0.0 0.1 -1.4 0.5
Hearing difficulty/problems: Yes 0.4 0.7 1.8 0.7 -1.4 0.0 -0.8 0.7 -0.8
Relative age of first facial hair 0.9 1.9 5.5 2.3 0.9 0.0 -0.1 2.1 -0.8
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.0 0.8 -1.0 0.0 0.3 0.5 -0.3
Ever used hormone-replacement therapy (HRT) 0.2 0.3 0.7 0.8 -0.3 0.0 0.0 -0.5 -0.8
Ever had hysterectomy (womb removed) 0.7 0.8 3.9 -0.3 -0.3 0.0 -2.0 -0.0 -0.6
Systolic blood pressure, automated reading 0.6 1.7 5.1 -2.2 1.5 0.0 0.5 0.3 1.5
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 2.1 -0.7 1.4 0.0 0.8 1.4 1.2
Angina 0.3 0.4 1.9 1.4 -0.5 0.0 0.2 0.2 -0.6
Medication for hormone replacement therapy 0.8 0.9 2.3 1.4 -1.2 0.0 0.1 -0.0 -1.5
Vitamin and mineral supplements 0.7 0.9 2.6 0.9 1.1 0.0 -1.6 -0.5 0.8
Supplements: Zinc 0.2 0.2 0.4 -0.7 0.6 0.0 -0.6 -0.2 -0.0
Medication: Co-codamol 3.1 3.5 8.8 0.7 -3.0 0.0 -2.1 -1.3 -2.4
Medication: Metformin 0.3 0.4 0.9 -0.6 0.5 0.0 -0.3 -1.0 0.9
Diabetes (father) 0.6 0.7 2.4 -0.5 -1.5 0.0 1.1 0.5 0.4
Diabetes (mother) 1.9 2.4 9.1 1.4 -1.3 0.0 -3.0 -1.1 -0.8
Severe depression (siblings) 1.0 1.1 3.9 -0.5 -1.4 0.0 0.2 -2.0 -0.8
Pack years adult smoking proportion 0.2 0.3 0.9 -0.3 -0.8 0.0 1.0 -0.2 -0.4
Impedance of leg (right) 0.3 1.5 5.1 -2.3 -0.9 0.0 -1.7 0.4 -0.2
Leg fat-free mass (left) 0.5 2.6 5.8 -0.6 2.4 0.0 2.2 -0.8 2.1
Trunk fat percentage 0.8 3.0 7.6 -2.1 2.8 0.0 1.9 -0.4 1.6
Hand grip strength (right) 0.2 0.5 1.4 1.1 0.2 0.0 1.2 0.6 -0.3
Townsend deprivation index at recruitment 0.9 1.2 3.8 0.9 -0.6 0.0 -1.9 -1.5 -0.5
Current tobacco smoking 1.2 1.9 5.3 1.1 -2.0 0.0 0.2 2.3 -1.0
Average weekly fortified wine intake 1.3 1.5 6.2 -1.4 0.3 0.0 2.5 0.5 0.7
Maternal smoking around birth 1.4 2.0 4.8 1.3 -1.6 0.0 -1.7 -0.0 -2.2
Fed-up feelings 0.4 0.8 4.1 -2.0 -0.3 0.0 -0.3 -0.5 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.6 5.0 -1.3 1.3 0.0 0.3 -2.2 1.1
Relative age voice broke 0.9 1.3 5.9 2.4 0.5 0.0 -0.5 1.2 -0.2
Taking other prescription medications 0.2 0.4 0.8 -0.9 -0.9 0.0 -0.0 -0.3 -0.7
Age when periods started (menarche) 2.1 5.0 13.6 2.1 -3.3 0.0 -0.4 0.5 -3.7
Bilateral oophorectomy (both ovaries removed) 3.4 3.9 13.2 -0.1 3.6 0.0 -0.4 0.2 3.2
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.8 5.0 1.2 0.8 0.0 -1.5 -2.2 1.1
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.4 0.5 0.5 0.0 0.5 0.2 0.6
Qualifications: CSEs or equivalent 1.1 1.5 5.4 2.3 -0.7 0.0 -0.2 1.4 -1.1
Serious illness, injury or assault to yourself 0.4 0.5 1.3 -0.2 -0.8 0.0 1.0 -0.4 -1.2
High blood pressure 1.5 4.1 10.0 -1.7 1.7 0.0 1.9 -3.2 2.2
Hayfever, allergic rhinitis or eczema 0.4 0.9 4.2 0.0 -0.0 0.0 0.4 -2.1 1.1
Multivitamins +/- minerals 0.9 1.1 3.8 0.7 -1.1 0.0 2.0 0.5 -0.8
Stomach or abdominal pain in last month 0.8 1.0 2.3 1.4 -1.0 0.0 -1.5 -1.0 -0.2
Supplements: Glucosamine 0.1 0.1 0.5 0.2 -0.1 0.0 0.2 0.4 -0.7
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 5.3 0.5 -2.3 0.0 0.6 1.1 -0.8
Medication: Atenolol 1.7 2.1 4.5 -1.6 2.1 0.0 1.2 1.4 1.4
Medication: Levothyroxine sodium 0.3 0.6 2.1 -0.0 0.5 0.0 -1.4 -0.1 1.0
Sitting height 0.1 0.4 0.8 -0.9 -0.6 0.0 0.5 -0.8 0.3
Chronic bronchitis/emphysema (father) 0.5 0.6 1.8 -0.3 0.5 0.0 1.3 0.9 0.7
High blood pressure (mother) 2.0 2.9 8.1 -1.1 1.0 0.0 2.0 -2.9 1.7
Body mass index (BMI) 0.8 3.3 8.4 -0.6 2.9 0.0 2.9 -0.3 1.7
Impedance of leg (left) 0.4 1.8 5.0 -2.2 -1.0 0.0 -2.1 0.4 -0.3
Leg predicted mass (left) 0.5 2.8 5.8 -0.7 2.4 0.0 2.3 -0.8 2.2
Trunk fat mass 0.9 3.7 8.4 -1.8 2.9 0.0 2.5 -0.6 1.9
Waist circumference 1.2 4.3 10.3 -1.6 3.2 0.0 2.0 -1.0 2.8
Number of incorrect matches in round 0.2 0.4 1.6 -0.3 -0.6 0.0 1.3 -0.5 0.3
Past tobacco smoking 0.1 0.3 0.8 -0.1 -0.2 0.0 0.9 -0.2 0.9
Alcohol usually taken with meals 0.7 1.2 4.6 1.3 0.3 0.0 0.7 0.2 2.1
Nervous feelings 0.5 0.9 2.1 -0.3 -1.4 0.0 -1.3 -1.2 -0.4
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 2.9 1.4 -0.9 0.0 -0.5 -1.7 0.3
Hearing difficulty/problems with background noise 0.8 1.3 4.1 -0.8 -2.0 0.0 -0.2 1.6 -1.0
Hair/balding pattern: Pattern 2 0.7 0.8 3.0 -1.7 -0.1 0.0 -0.8 0.2 1.1
Had menopause 0.3 0.4 1.6 -1.3 0.2 0.0 -0.3 -0.5 -0.5
Had other major operations 0.2 0.3 1.2 -0.4 0.1 0.0 -0.2 -0.5 1.1
Forced vital capacity (FVC) 0.4 1.5 3.4 -1.2 1.3 0.0 0.5 -1.5 1.9
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.4 3.9 1.2 1.6 0.0 -2.0 -1.8 1.7
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 4.6 0.4 -0.4 0.0 0.8 -2.1 -0.7
Qualifications: None of the above 1.4 3.1 7.4 -0.6 -2.7 0.0 -1.9 -0.2 -2.6
Financial difficulties in last 2 years 0.3 0.4 1.5 -1.2 -0.3 0.0 0.7 0.3 0.5
Mouth/teeth dental problems 0.6 1.0 4.6 2.2 0.2 0.0 -0.0 0.9 -0.7
Heart attack 0.9 1.1 2.2 0.4 1.2 0.0 1.5 -0.9 1.5
Allergy 0.4 1.0 4.9 0.3 0.8 0.0 -0.2 2.2 -0.2
Pain all over the body in last month 1.5 1.6 3.8 -1.3 -1.9 0.0 -0.3 0.6 -1.9
Diabetes (self-reported) 0.5 0.7 4.0 0.5 0.3 0.0 0.0 -2.0 0.3
Hayfever/allergic rhinitis (self-reported) 0.1 0.2 0.8 0.5 -0.9 0.0 0.1 0.2 -0.3
Medication: Ramipril 0.8 1.1 2.4 -1.5 1.5 0.0 0.7 -1.2 0.1
Medication: Simvastatin 0.0 0.1 0.2 0.4 0.2 0.0 0.5 0.0 0.0
Fluid intelligence score 0.2 0.3 1.0 -0.4 0.6 0.0 -0.2 0.6 1.0
Illnesses of siblings 0.8 1.1 4.8 -0.7 -1.1 0.0 -2.2 0.2 -0.4
Neuroticism score 0.5 1.0 3.2 -0.3 -1.8 0.0 -0.3 -1.5 -0.9
Weight 1.0 5.0 10.4 -1.5 3.2 0.0 3.0 -1.0 2.7
Impedance of arm (right) 0.3 1.5 2.8 -1.3 -1.6 0.0 -1.4 0.3 -1.7
Arm fat percentage (right) 0.6 2.3 5.9 -0.8 2.4 0.0 2.4 -0.0 1.3
Trunk fat-free mass 0.4 2.2 6.0 0.2 1.6 0.0 2.4 -0.4 2.1
Hip circumference 1.0 4.2 10.8 -1.4 2.7 0.0 3.3 -0.5 2.1
Time employed in main current job 3.2 3.7 8.1 -2.1 1.9 0.0 2.4 -0.9 2.9
Alcohol intake versus 10 years previously 0.5 0.7 2.3 -1.1 -0.4 0.0 0.9 -1.5 0.1
Father’s age at death 1.4 1.9 6.2 1.5 -1.7 0.0 -2.5 0.0 -0.5
Worrier / anxious feelings 0.4 0.7 1.8 -0.0 -1.3 0.0 -0.1 -1.3 -0.7
Frequency of tiredness / lethargy in last 2 weeks 1.6 2.6 5.8 -1.5 1.1 0.0 1.4 -2.4 2.1
Falls in the last year 0.3 0.4 1.8 -0.6 1.4 0.0 -0.1 -0.1 0.5
Hair/balding pattern: Pattern 3 2.0 2.9 9.9 3.1 -1.6 0.0 -0.6 0.6 -2.1
Number of live births 0.2 0.3 1.5 -0.0 -0.5 0.0 0.1 1.2 -0.3
Forced expiratory volume in 1-second (FEV1) 0.7 2.2 7.3 -0.5 1.9 0.0 0.2 -1.4 2.7
Pulse rate 0.8 1.4 5.1 0.8 -0.1 0.0 0.4 2.2 -1.5
Happiness 1.9 2.3 5.7 0.7 -1.9 0.0 -0.7 -1.9 -2.4
Noisy workplace 0.2 0.2 0.9 0.1 -0.6 0.0 0.2 -0.9 0.0
Qualifications: A levels/AS levels or equivalent 1.0 2.1 5.0 2.2 -0.6 0.0 -1.5 -2.2 0.3
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.6 -0.2 -0.8 0.0 -0.2 0.5 0.7
Mouth/teeth dental problems: Dentures 0.2 0.3 1.5 -0.6 0.1 0.0 0.0 1.2 0.1
Asthma 0.0 0.1 0.2 -0.3 -0.1 0.0 0.5 -0.3 -0.0
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 0.8 0.9 -0.6 0.0 -0.4 0.9 0.5
Medication: Cholesterol lowering 0.9 1.4 6.6 0.7 0.9 0.0 2.6 0.3 0.7
Depression (self-reported) 1.3 1.5 5.2 -2.3 -1.5 0.0 0.6 -1.0 -0.6
Medication: Lansoprazole 0.9 1.1 2.4 -1.2 1.5 0.0 -0.7 -0.2 1.5
Prospective memory result 1.6 1.9 6.2 0.8 -1.8 0.0 -1.2 0.3 -2.5
Lung cancer (father) 0.2 0.2 0.6 0.0 -0.8 0.0 -0.7 0.5 0.0
Illnesses of mother 0.5 0.7 1.6 1.1 1.3 0.0 -0.2 1.0 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.3 7.1 -0.8 1.8 0.0 0.5 -1.6 2.7
Pulse wave Arterial Stiffness index 0.7 0.8 4.0 -0.5 -0.6 0.0 -0.3 2.0 -0.6
Impedance of arm (left) 0.3 1.6 3.3 -1.4 -1.5 0.0 -1.8 0.1 -1.3
Arm fat mass (right) 0.9 3.7 9.8 -0.9 3.1 0.0 2.6 -0.2 2.1
Trunk predicted mass 0.4 2.2 6.1 0.4 1.6 0.0 2.5 -0.2 2.0
Standing height 0.2 1.9 4.6 -2.1 0.9 0.0 0.5 -1.3 2.0
Length of working week for main job 0.2 0.3 0.9 0.7 0.2 0.0 -0.9 -0.3 -0.2
Exposure to tobacco smoke at home 0.2 0.2 0.8 -0.5 0.3 0.0 0.9 -0.2 -0.2
Breastfed as a baby 0.5 0.6 2.6 -1.6 0.3 0.0 0.1 -0.8 0.3
Tense / ‘highly strung’ 0.8 1.3 3.9 -2.0 -1.4 0.0 -1.0 -0.4 -0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.8 4.6 -2.1 -0.3 0.0 1.2 -2.1 0.4
Hair/balding pattern: Pattern 4 0.5 1.2 2.7 -1.6 1.0 0.0 0.5 -1.6 0.9
Birth weight of first child 0.3 0.5 2.1 -0.4 -0.1 0.0 0.5 1.5 -0.8
Peak expiratory flow (PEF) 1.1 2.6 5.5 2.2 2.3 0.0 -1.4 -1.2 1.4
Pulse wave reflection index 0.6 0.7 3.2 -0.4 -0.0 0.0 -1.8 1.0 0.2
Ever highly irritable/argumentative for 2 days 0.1 0.2 0.4 0.6 -0.5 0.0 0.2 -0.1 -0.6
Loud music exposure frequency 2.6 2.8 12.5 0.9 -1.0 0.0 -3.5 -0.2 -1.7
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 4.7 0.7 -0.1 0.0 -1.1 -2.2 0.0
Mouth/teeth dental problems: Bleeding gums 1.5 1.9 8.5 -2.9 0.3 0.0 0.5 -1.3 0.9
Blood clot in the leg (DVT) 0.4 0.5 1.0 -0.4 0.0 0.0 -1.0 -0.7 1.0
Medication: Paracetamol 0.2 0.3 1.3 -0.5 -0.5 0.0 0.2 -1.1 -0.2
Headache pain in last month 0.1 0.2 1.0 0.0 -1.0 0.0 0.2 -0.1 0.3
Medication for cholesterol, blood pressure or diabetes 1.4 2.4 12.2 0.4 -1.0 0.0 -3.5 0.3 -0.8
Glaucoma (self-reported) 0.8 0.9 1.6 -1.0 -1.2 0.0 1.1 -1.3 -0.2
Gout (self-reported) 0.3 0.5 1.7 -1.3 0.1 0.0 -0.2 -1.0 -0.1
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 2.0 0.5 -0.1 0.0 -1.4 -1.0 0.5
Medication: Amlodipine 0.3 0.4 1.0 -0.2 0.6 0.0 -0.5 -0.9 1.0
Medication: Ventolin 100micrograms inhaler 0.7 0.9 1.8 0.7 -1.1 0.0 -1.3 -1.0 -0.8
Birth weight 0.3 0.6 1.7 -1.3 0.9 0.0 0.3 0.6 0.8
Chronic bronchitis/emphysema (mother) 0.9 1.0 2.7 -0.6 -1.6 0.0 -0.1 -0.8 -1.6
High blood pressure (siblings) 0.4 0.6 1.7 1.3 0.3 0.0 1.2 -0.2 -0.8
Forced vital capacity (FVC), Best measure 0.2 0.9 2.0 -1.0 0.7 0.0 0.1 -1.2 1.4
Body fat percentage 0.8 3.0 7.3 -2.0 2.7 0.0 2.1 0.0 1.5
Leg fat percentage (right) 0.7 2.4 5.0 -1.7 2.2 0.0 2.2 0.0 1.4
Arm fat-free mass (right) 0.8 3.9 8.6 -0.5 2.8 0.0 2.5 -0.7 2.9
Exposure to tobacco smoke outside home 0.7 0.9 2.5 0.8 -1.6 0.0 -1.5 -0.5 0.0
Comparative body size at age 10 0.3 0.9 2.0 -0.1 1.4 0.0 1.2 1.4 0.2
Number of full brothers 1.1 1.3 2.8 -1.2 1.4 0.0 1.2 1.7 0.6
Worry too long after embarrassment 0.7 1.1 2.3 1.1 -1.3 0.0 -1.5 -1.1 -0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.7 2.4 -1.6 -0.7 0.0 0.9 0.5 -0.7
Wheeze or whistling in the chest in last year 0.3 0.5 1.9 0.6 -1.4 0.0 -0.0 0.3 -0.8
Number of children fathered 0.9 1.0 4.2 -0.6 -0.6 0.0 1.0 2.0 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 3.1 3.6 9.5 -1.0 2.0 0.0 0.5 -3.1 2.6
Age at first live birth 0.4 0.6 2.0 0.7 0.9 0.0 -0.6 0.2 1.4
Pulse wave peak to peak time 1.0 1.2 5.0 0.3 1.0 0.0 0.3 -2.2 1.0
Health satisfaction 0.7 1.0 1.9 1.4 -0.5 0.0 1.2 1.0 -1.0
Shortness of breath walking on level ground 1.0 1.2 3.2 0.1 -1.4 0.0 1.1 1.0 -1.8
Qualifications: College or University degree 1.0 3.1 8.5 -1.0 2.2 0.0 1.7 -1.2 2.9
Eye problems/disorders: None of the above 0.5 0.6 2.3 -0.5 1.5 0.0 0.2 0.2 0.9
Mouth/teeth dental problems: Loose teeth 0.9 1.1 3.8 -2.0 0.2 0.0 -1.1 -0.9 0.8
Emphysema/chronic bronchitis 1.1 1.3 4.5 0.7 -0.9 0.0 1.2 0.6 -2.1
Medication for pain relief, constipation, heartburn 0.2 0.3 0.8 -0.3 0.0 0.0 -0.5 0.9 -0.7
Neck or shoulder pain in last month 0.6 0.8 2.0 1.3 -1.4 0.0 0.5 0.6 -1.0
Medication: Blood pressure 1.7 3.0 12.7 -0.3 1.5 0.0 3.6 -0.8 1.5
Angina (self-reported) 0.3 0.4 1.7 1.3 -0.4 0.0 0.2 0.2 -0.6
Migraine (self-reported) 0.9 1.1 3.3 1.8 -0.6 0.0 1.7 -0.2 -0.2
Medication: Ibuprofen 0.7 0.8 2.9 0.9 -0.9 0.0 -0.5 1.7 -0.6
Medication: Allopurinol 0.4 0.6 2.2 -1.5 0.6 0.0 0.1 -1.0 0.1
Medication: Omeprazole 0.3 0.4 1.2 -0.4 1.1 0.0 -0.2 0.6 0.7
Medication: Seretide 50 evohaler 0.6 0.7 3.0 0.6 -0.2 0.0 0.8 1.7 -0.6
Mean time to correctly identify matches 0.2 0.3 1.8 -0.1 0.1 0.0 -1.4 -0.2 0.1
Heart disease (mother) 0.6 0.7 4.0 -0.2 -0.3 0.0 -2.0 0.3 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 1.0 -0.7 0.7 0.0 -0.4 1.0 -0.4
Whole body fat mass 1.0 4.1 10.0 -1.7 3.2 0.0 2.7 -0.2 2.1
Leg fat mass (right) 1.0 3.9 8.7 -1.9 3.0 0.0 2.5 -0.2 2.1
Arm predicted mass (right) 0.6 3.0 6.8 -0.5 2.4 0.0 2.2 -0.5 2.6
Pulse rate, automated reading 0.3 1.0 4.7 -0.3 -0.3 0.0 -0.4 2.2 -0.8
Alcohol intake frequency. 0.1 0.3 1.0 -0.1 0.3 0.0 1.0 0.6 -0.7
Comparative height size at age 10 0.4 2.2 9.7 -3.1 1.3 0.0 0.0 -0.4 1.3
Number of full sisters 0.1 0.2 0.5 -0.5 0.7 0.0 0.3 0.4 -0.2
Suffer from ‘nerves’ 0.3 0.5 2.1 -1.4 -0.6 0.0 -0.3 -0.5 0.1
Overall health rating 0.3 0.6 2.3 -1.5 0.3 0.0 0.3 -0.8 0.6
Chest pain or discomfort 0.6 0.9 2.8 0.1 1.4 0.0 1.7 0.3 0.8
Had major operations 0.7 0.8 3.4 1.9 -0.4 0.0 0.3 1.1 -0.0
Age at last live birth 0.6 0.9 4.2 -0.5 0.9 0.0 -0.5 -0.0 2.0
Family relationship satisfaction 1.7 2.1 7.9 0.5 -1.6 0.0 -0.6 -2.8 -1.3
Leg pain on walking 0.4 0.6 1.8 0.4 0.8 0.0 1.3 0.2 0.8
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.4 1.7 0.6 -0.6 0.0 -0.3 -0.2 -1.3
Commuting to job workplace: Car/motor vehicle 0.9 1.1 3.9 0.8 0.2 0.0 1.2 2.0 0.5
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.5 1.1 0.0 0.0 -1.2 0.1 -1.1
Medication: Aspirin 0.7 0.9 2.1 0.9 0.6 0.0 1.4 -1.0 1.0
Supplements: Vitamin C 0.6 0.7 2.3 -0.9 0.4 0.0 1.5 -0.9 0.6
Knee pain experienced in last month 0.3 0.5 1.8 -0.5 0.8 0.0 1.3 -0.7 -0.1
Hypertension (Self-reported) 1.3 3.7 8.0 -1.8 1.8 0.0 1.6 -2.8 2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 3.0 -1.6 1.7 0.0 -0.1 0.8 1.4
Illnesses of father: Heart disease 1.2 1.7 3.8 1.1 1.3 0.0 -0.0 -2.0 1.8
Illnesses of siblings: Diabetes 0.8 1.0 3.1 0.5 1.8 0.0 0.4 -0.8 1.3
Smoking status: Previous 0.6 0.8 2.7 -0.3 0.7 0.0 -1.6 -0.9 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 3.0 0.3 -1.0 0.0 -1.7 0.6 -1.1
Whole body fat-free mass 0.4 2.5 5.7 -0.1 2.1 0.0 2.4 -0.5 2.2
Leg fat-free mass (right) 0.4 2.2 4.7 -0.3 2.2 0.0 1.9 -0.9 1.9
Arm fat percentage (left) 0.5 2.2 5.7 -0.9 2.4 0.0 2.2 -0.1 1.3
Average weekly red wine intake 1.2 1.7 4.5 2.1 1.1 0.0 -0.2 1.0 1.9
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.6 -0.1 -0.8 0.0 -0.2 -0.1 0.2
Mood swings 0.6 1.1 3.2 -1.5 -1.1 0.0 0.1 -1.8 -0.5
Loneliness, isolation 1.4 1.9 8.1 -0.9 0.8 0.0 -0.1 -2.9 1.3
Long-standing illness, disability or infirmity 0.3 0.5 1.0 -0.1 -1.0 0.0 0.0 -1.0 -1.0
Ever had bowel cancer screening 0.2 0.2 1.2 0.1 0.2 0.0 1.1 0.4 0.2
Diabetes diagnosed by doctor 0.4 0.7 3.4 0.8 0.4 0.0 -0.3 -1.8 0.1
Ever had stillbirth, spontaneous miscarriage or termination 1.7 1.8 3.9 -0.6 1.8 0.0 2.0 1.8 0.1
Friendships satisfaction 0.9 1.1 3.2 -0.2 -1.5 0.0 -0.9 -1.8 -0.7
Qualifications: nursing, teaching 0.6 0.9 1.5 1.2 0.7 0.0 1.2 1.1 1.0
Commuting to job workplace: Walk 0.3 0.3 0.8 -0.0 -0.1 0.0 -0.7 -0.8 0.9
Eye problems/disorders: Cataract 0.6 0.7 2.2 -0.1 -1.5 0.0 -1.2 0.5 -0.7
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.8 -0.4 0.5 0.0 -0.5 -0.9 0.5
Medication for cholesterol 0.6 0.9 4.9 0.5 0.1 0.0 0.7 2.2 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 2.4 0.3 -1.5 0.0 0.4 0.1 -1.3
Back pain experienced in last month 0.4 0.5 1.6 0.9 -0.5 0.0 0.3 -0.6 -1.3
Mineral and other dietary supplements 0.4 0.6 2.3 -0.4 0.9 0.0 0.3 -0.0 1.5
Breast cancer (self-reported) 1.1 1.3 3.6 -1.9 1.0 0.0 0.8 -1.2 0.9
Asthma (self-reported) 0.0 0.1 0.4 -0.3 0.1 0.0 0.6 -0.3 -0.0
Osteoporosis (self-reported) 0.7 0.8 3.1 1.1 -0.6 0.0 -0.3 1.8 -0.5
Osteoarthritis (self-reported) 1.6 2.0 4.3 1.8 -0.9 0.0 -1.7 -0.9 -2.1
Medication: Aspirin 0.4 0.5 1.1 0.5 0.6 0.0 0.7 -1.0 1.1
Medication: Gliclazide 1.4 1.6 3.2 -1.8 1.5 0.0 1.2 -0.4 1.5
Illnesses of father: None of the above (group 1) 0.7 0.9 3.1 0.6 -1.2 0.0 0.2 0.8 -1.8
Smoking status: Current 1.1 1.8 4.3 1.1 -2.0 0.0 -0.1 2.1 -1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 1.5 0.3 0.8 0.0 0.4 -0.7 1.2
Whole body water mass 0.5 2.6 6.0 0.0 2.1 0.0 2.4 -0.4 2.3
Leg predicted mass (right) 0.4 2.1 4.6 -0.2 2.1 0.0 1.9 -0.8 1.8
Arm fat mass (left) 0.9 3.6 9.1 -0.9 3.0 0.0 2.6 -0.4 2.1
Number of self-reported non-cancer illnesses 0.6 1.1 2.9 -0.3 0.6 0.0 1.1 -1.7 1.3
Average weekly champagne plus white wine intake 0.3 0.4 1.0 -0.3 -0.8 0.0 -0.1 -0.6 1.0
Miserableness 0.5 0.9 3.3 -1.8 -0.9 0.0 0.2 -1.1 0.1
Guilty feelings 1.2 1.7 4.8 0.5 -2.2 0.0 -0.1 -2.1 -1.0
Wears glasses or contact lenses 0.5 0.5 1.5 0.3 -0.6 0.0 1.2 1.1 0.4
Ever taken oral contraceptive pill 0.6 0.7 2.8 -0.1 -1.7 0.0 0.9 -0.7 -0.1
Hearing aid user 3.7 4.2 7.8 1.8 -2.8 0.0 -1.7 2.6 -2.1
Mother’s age at death 1.1 1.3 3.3 1.8 -1.1 0.0 -0.5 1.8 -0.2
Financial situation satisfaction 0.7 0.9 2.6 0.4 -1.6 0.0 -0.1 0.2 -1.6
Tinnitus: Yes, now most or all of the time 0.5 0.6 2.3 0.5 -0.0 0.0 1.0 1.5 -0.0
Commuting to job workplace: Public transport 1.5 1.8 8.5 0.1 -0.7 0.0 -2.9 -0.9 -0.8
Eye problems/disorders: Glaucoma 0.5 0.6 1.8 -0.3 -0.5 0.0 1.1 -1.3 -0.4
Medication: Blood pressure 1.1 2.2 4.8 -2.2 1.2 0.0 -1.4 -1.9 1.0
Pain type(s) experienced in last month: Hip pain 0.2 0.3 1.3 0.7 -0.0 0.0 -0.1 -1.1 -0.1
Supplements: Fish oil (including cod liver oil) 1.7 2.2 7.1 0.2 -2.0 0.0 -1.2 0.7 -2.7
High cholesterol (Self-reported) 0.5 0.9 3.1 -0.8 0.6 0.0 0.5 -1.8 1.0
Medication: Bendroflumethiazide 2.0 3.0 8.2 -2.9 1.7 0.0 1.1 -0.3 2.3
Medication: Paracetamol 0.3 0.4 1.3 -0.7 -0.8 0.0 -0.2 -0.2 -1.1
Medication: Lisinopril 2.2 2.9 5.5 -1.0 2.4 0.0 2.1 -1.0 2.3
Medication: Atorvastatin 0.3 0.3 0.8 0.9 0.3 0.0 0.9 -0.4 0.5
Illnesses of father: High blood pressure 0.3 0.4 1.7 0.3 0.7 0.0 1.3 -0.3 0.2
Alcohol drinker status: Never 0.3 0.4 1.4 0.5 1.2 0.0 0.1 0.4 0.8
Ever smoked 0.1 0.1 0.5 -0.7 -0.1 0.0 -0.3 0.1 -0.2
Basal metabolic rate 0.6 3.4 6.7 -0.6 2.5 0.0 2.5 -0.7 2.6
Leg fat percentage (left) 0.7 2.5 5.5 -2.0 2.3 0.0 2.0 -0.0 1.3
Arm fat-free mass (left) 0.7 3.4 7.3 -0.3 2.7 0.0 2.4 -0.5 2.6
Number of operations (self-reported) 0.4 0.7 2.1 -0.5 0.5 0.0 -0.6 -1.5 1.0
Average weekly beer plus cider intake 0.5 0.7 1.7 -1.3 0.1 0.0 1.0 1.1 -0.4
Irritability 1.3 2.1 7.9 -0.1 -2.8 0.0 -1.1 -1.1 -1.6
Risk taking 0.9 1.3 3.6 1.8 0.1 0.0 1.9 -0.6 0.8
Ever had prostate specific antigen (PSA) test 0.7 0.8 4.8 0.3 0.0 0.0 2.2 0.2 0.2
Fractured/broken bones in last 5 years 2.3 3.0 6.5 2.0 -2.6 0.0 -1.7 -0.7 -2.1
Age started oral contraceptive pill 2.0 2.6 5.6 -2.4 2.2 0.0 1.2 -0.1 1.9
Diastolic blood pressure, automated reading 0.6 1.8 3.9 -2.0 1.6 0.0 0.9 0.8 1.7
Ever depressed for a whole week 0.5 0.6 2.3 0.0 -0.3 0.0 0.6 -1.5 -0.9
Unable to work because of sickness or disability 1.1 1.4 6.8 -2.6 -0.8 0.0 0.4 0.6 -0.8
Commuting to job workplace: Cycle 1.0 1.2 4.2 -0.8 1.4 0.0 -0.1 -2.0 0.3
Myopia 1.6 2.4 6.8 0.4 -2.6 0.0 -2.1 -1.3 -1.1
Vascular/heart problems diagnosed by doctor 1.5 4.0 9.8 1.4 -1.8 0.0 -2.2 3.1 -2.1
Cholesterol lowering medication 1.2 1.7 7.4 0.2 -0.2 0.0 -1.7 -2.7 0.0
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 3.5 -0.1 1.9 0.0 -0.3 0.1 1.2
Pain experienced in last month 0.9 1.4 4.1 -2.0 1.3 0.0 -0.2 0.9 1.4
Supplements: Calcium 1.6 1.8 3.7 1.9 -0.8 0.0 -1.2 1.8 -1.4
Basal cell carcinoma (self-reported) 0.5 0.6 2.4 -0.8 -0.1 0.0 -1.6 -0.7 0.0
Heart attack/myocardial infarction (self-reported) 0.7 0.9 1.5 0.5 1.0 0.0 1.2 -0.9 1.2
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.0 -1.0 -0.2 0.0 -0.7 -0.5 0.7
Heart disease (siblings) 1.3 1.6 4.3 -2.0 0.6 0.0 2.1 0.8 0.5
Alcohol drinker status: Previous 0.4 0.5 2.6 -0.4 -0.0 0.0 1.6 0.5 0.1
Pack years of smoking 0.3 0.4 1.5 -0.3 -0.6 0.0 1.2 -0.6 -0.3
Impedance of whole body 0.4 2.1 5.1 -2.1 -1.4 0.0 -2.3 0.1 -1.1
Leg fat mass (left) 1.0 4.1 9.5 -2.1 3.1 0.0 2.5 -0.2 2.1
Arm predicted mass (left) 0.6 3.0 6.2 -0.4 2.5 0.0 2.4 -0.4 2.4