Hub : Genes

GPC6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.5070	0.0610	0.0e+00	0.359	NA	0.446	NA	0.422	9.9e-21	NA	6.3e-27	NA	4.1e-25
2	GTEx	Artery Coronary	0.7020	0.0740	1.0e-11	0.225	NA	0.364	NA	0.302	3.9e-08	NA	3.6e-13	NA	8.5e-11
3	GTEx	Artery Tibial	0.2572	0.0474	6.6e-11	0.207	NA	0.220	NA	0.248	4.0e-16	NA	3.6e-17	NA	1.9e-19
4	GTEx	Heart Atrial Appendage	0.2200	0.0560	3.3e-05	0.166	NA	0.249	NA	0.271	6.4e-08	NA	1.5e-11	NA	1.5e-12
5	GTEx	Heart Left Ventricle	0.2130	0.0687	7.0e-04	0.012	NA	0.004	NA	0.027	7.2e-02	NA	1.9e-01	NA	1.4e-02
6	GTEx	Testis	0.6600	0.0660	3.2e-09	0.244	NA	0.270	NA	0.239	3.5e-11	NA	2.3e-12	NA	6.0e-11
7	GTEx	Thyroid	0.1870	0.0430	6.2e-06	0.159	NA	0.124	NA	0.143	3.1e-12	NA	9.7e-10	NA	4.8e-11
8	TCGA	Liver Hepatocellular Carcinoma	0.1790	0.0730	9.3e-03	0.004	0.028	0.051	NA	0.000	1.9e-01	1.7e-02	2.0e-03	NA	3.1e-01
9	TCGA	Lung Adenocarcinoma	0.0886	0.0361	3.0e-03	-0.001	0.044	0.009	NA	0.002	4.2e-01	6.2e-06	2.5e-02	NA	1.8e-01
10	TCGA	Thyroid Carcinoma	0.2590	0.0460	4.0e-12	0.245	0.160	0.226	NA	0.241	9.9e-24	2.2e-15	9.5e-22	NA	3.1e-23

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	1.5	2.4	6.5	2.6	2.6	1.4	1.9	2.2	0.7	0.3	-0.5	-0.3	0.4
Bipolar Disorder or Schizophrenia	2.9	7.1	19.0	4.4	4.0	4.0	3.5	2.1	-0.1	0.5	-0.8	1.0	0.7
Depressed Affect (Nagel 2018)	1.6	3.4	6.4	-1.4	-2.5	-2.5	-1.9	0.3	1.9	2.3	-1.1	-1.3	2.2
Depression (Nagel 2018)	1.6	2.5	8.3	-0.2	-1.4	-0.8	-1.1	-0.6	2.0	2.9	-0.1	-0.5	2.8
Intelligence (Savage-Jansen 2018)	0.8	2.4	10.4	0.5	1.5	1.2	1.4	0.8	1.7	1.0	-1.5	3.2	1.0
Neuroticism (Nagel 2018)	1.0	2.3	6.3	0.4	-0.3	-1.0	0.1	2.3	1.8	2.5	-0.2	-1.2	2.4
Schizophrenia (2018)	2.5	5.3	16.4	3.6	3.2	4.1	3.0	1.0	-0.5	0.4	-0.6	1.6	0.6
Schizophrenia vs Biploar Disorder	1.7	2.3	8.1	1.8	1.7	2.8	2.0	-0.2	-1.2	0.7	-0.6	1.4	0.8
Worry (Nagel 2018)	1.0	2.1	11.6	0.9	1.1	-0.5	0.7	3.4	-0.2	1.6	-0.0	-1.3	1.6
Alzheimer’s Disease (in mother)	0.6	0.7	1.7	0.4	1.3	0.8	0.6	0.3	1.1	1.0	0.9	0.4	0.9
Alzheimer’s Disease (in father)	0.7	0.7	2.6	0.1	0.3	0.2	0.1	0.0	-1.6	-1.0	0.7	-1.5	-0.9
Alzheimer’s Disease (including proxy)	1.1	1.6	4.0	1.1	2.0	1.2	1.3	1.5	0.6	1.6	0.4	0.2	1.4
Crohns Disease (2017)	0.5	1.0	4.4	0.9	-0.9	0.1	-0.1	-0.7	-0.8	-0.5	1.6	-2.1	-0.7
Irritable Bowel Disease (IBD)	0.3	0.7	2.4	1.2	-0.1	0.4	0.2	0.2	-0.4	1.5	0.9	-0.2	1.4
Ulcerative Colitis (UC)	0.9	1.8	6.3	1.2	0.6	0.5	0.5	1.1	-0.4	2.5	0.1	1.3	2.5
Major Depression (MDD)	2.3	2.7	5.8	1.7	1.8	1.2	1.4	1.2	2.0	2.4	0.6	0.9	2.4
Reaction Time	0.6	1.1	3.5	0.4	1.5	0.3	0.5	1.0	1.9	0.9	1.3	-0.4	1.0
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.8	0.1	0.1	0.5	0.4	-0.1	1.3	-0.6	-1.3	0.6	-0.6
Breast Cancer	0.3	0.7	3.4	-0.5	0.2	-0.7	-0.6	-0.3	-1.8	-0.7	0.6	1.1	-0.8
Ovarian Cancer	0.9	1.2	3.9	-1.4	-2.0	-1.0	-1.2	-1.4	0.1	0.0	-0.7	-0.8	0.1
Prostate Cancer	0.6	0.9	4.2	0.9	0.4	2.0	1.3	0.2	-1.2	-0.5	0.1	0.3	-0.6
Age at First Birth	0.6	0.8	3.3	0.6	-0.5	0.6	-0.0	-0.9	0.3	-1.7	-0.1	0.4	-1.8
Bipolar Disorder (2011)	4.1	4.0	9.4	3.1	1.9	1.6	2.3	2.4	-0.7	-2.0	1.4	-1.9	-1.9
Body Mass Index (BMI) (2010)	1.4	1.9	5.9	-1.3	-0.4	-1.2	-1.1	-1.3	-0.9	2.4	-0.5	0.9	2.3
Coronary Artery Disease (CAD)	0.3	0.4	2.9	0.3	0.1	0.2	-0.1	0.1	1.7	0.4	0.1	0.5	0.4
Crohns Disease (2012)	0.5	0.8	2.3	1.3	0.2	0.8	0.5	-0.0	-0.2	-0.8	1.5	-1.2	-0.9
Mean Putamen Volume	0.8	1.0	3.0	-0.6	0.1	-0.8	-1.0	-1.7	0.4	-1.3	-0.6	0.7	-1.4
Fasting Glucose	1.0	1.2	7.5	-0.0	-0.3	0.4	0.1	-0.7	-1.0	1.4	2.7	-0.6	0.9
HbA1C	0.3	0.3	1.4	-0.6	0.2	-0.9	-0.6	-0.6	-0.2	0.3	-1.2	-0.2	-0.1
HDL Cholesterol	1.4	2.4	9.1	-0.1	-0.3	-0.2	0.2	0.9	-0.2	-2.9	2.1	-0.9	-3.0
LDL Cholesterol	0.9	1.5	3.8	-0.7	0.3	-0.3	-0.3	0.4	0.9	1.8	-1.7	2.0	1.7
Lupus	1.8	2.7	9.7	0.1	0.3	0.8	0.0	-1.5	-1.0	-2.6	3.1	-0.7	-2.5
Neuroticism (2016)	1.0	1.5	5.9	0.0	-0.2	0.4	0.6	1.5	0.5	2.4	0.2	-0.0	2.4
Primary Biliary Cirrhosis	0.1	0.1	0.5	0.0	0.1	-0.4	-0.4	0.3	0.0	0.0	-0.7	0.5	0.1
Rheumatoid Arthritis	0.3	0.4	1.7	-0.4	-0.5	-0.6	-0.5	-1.3	-0.6	-0.6	0.4	-0.4	-0.6
Schizophrenia (2014)	2.5	5.6	16.1	3.7	3.3	4.0	3.2	1.6	-1.1	-0.4	-0.8	0.6	-0.3
Triglycerides	1.2	2.0	4.7	-1.7	-0.3	-1.3	-1.5	-1.7	-0.1	2.0	-1.2	0.4	2.2
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.6	0.8	0.4	0.5	0.7	0.2	0.0	0.2	-0.1	0.0	0.3
Ulcerative Colitis	1.2	1.7	5.6	-0.0	0.6	-0.7	-0.3	1.2	1.4	2.2	0.7	1.3	2.4
Blood Eosinophil Count	0.0	0.4	1.0	-0.2	-0.5	-0.9	-0.9	-0.7	-0.5	0.2	-0.1	1.0	0.1
Blood Platelet Count	0.2	2.5	7.7	-1.0	-0.6	-1.3	-2.2	-2.6	-1.3	0.3	-0.7	2.8	0.4
Blood Red Count	0.3	2.6	6.3	-2.0	-0.9	-2.0	-2.5	-2.5	-1.6	0.5	-0.8	-0.8	0.6
Blood White Count	0.2	1.8	4.2	-0.4	-1.1	-0.8	-1.4	-1.3	0.2	2.0	-1.2	1.7	2.0
Heel T-Score	1.3	10.6	28.4	0.4	-1.4	2.7	2.6	0.4	-2.7	-5.3	-4.8	-1.6	-5.3
BMI	0.6	3.4	12.5	-0.7	-1.2	-1.4	-1.2	-0.1	1.9	3.5	0.6	1.0	3.5
Height	0.1	2.1	5.8	-1.4	-0.6	-0.5	-0.6	-0.9	0.6	2.4	-2.0	1.5	2.2
Waist Hip Ratio (WHR)	0.2	0.8	2.1	-0.4	0.5	-0.6	-1.0	-1.5	1.5	0.4	1.2	0.1	0.3
Systolic Blood Pressure	0.8	4.1	9.2	2.9	3.0	2.1	2.3	1.8	0.9	1.7	-1.7	0.9	1.9
Smoking Status	0.2	0.6	2.2	-0.3	-0.5	0.2	-0.3	-1.3	1.5	0.9	0.5	-0.2	0.8
Allergy or Eczema	0.3	0.8	2.2	-0.9	-0.7	-0.7	-0.8	-0.8	-0.9	-0.2	-1.4	1.5	-0.2
Cardiovascular Disease	0.2	0.7	3.7	0.0	-0.3	-0.6	-0.5	-0.8	1.9	0.9	0.6	0.4	1.0
Hypothyroidism (self reported)	0.3	0.7	1.7	-1.1	-0.8	-1.3	-1.1	-0.3	-0.8	0.1	0.5	-1.1	0.1
Respiratory disease	0.3	0.7	1.9	-0.1	-0.4	-1.0	-0.5	0.1	-0.6	1.4	-0.5	1.3	1.3
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.3	-0.2	-0.5	-0.3	-0.4	-0.2	0.1	0.5	0.4	0.0	0.6
Lung FEV1/FVC ratio	0.4	2.1	6.1	1.1	0.5	0.7	0.6	-0.0	-1.2	-2.0	2.5	-1.7	-1.9
Lung FVC	0.2	1.1	6.5	-0.7	0.2	0.5	0.8	1.0	-1.0	0.8	-2.6	0.4	0.8
Neuroticism	1.3	3.1	11.1	1.4	0.5	0.0	1.1	3.3	0.9	2.7	-0.6	-0.6	2.7
Chronotype (morning person)	4.8	11.1	32.9	-1.5	-2.9	-1.3	-1.1	-0.8	-2.6	-5.7	3.3	-3.8	-5.6
Hair Pigment	0.0	1.4	3.9	0.4	-0.9	-0.1	0.6	-0.7	-2.0	-0.7	1.8	-1.7	-1.1
Tanning	0.0	0.5	1.2	0.2	0.4	0.5	0.0	-0.6	-1.1	0.9	0.8	1.0	0.7
Hand grip strength (left)	0.4	1.1	2.7	1.3	-0.1	1.3	1.1	-0.3	-0.5	1.0	-1.6	0.9	1.0
Number of treatments/medications taken	0.4	0.7	3.5	-0.6	-0.6	-1.0	-1.1	0.1	0.1	-0.6	0.7	-1.9	-0.3
Average weekly spirits intake	1.3	1.6	6.2	0.3	-0.6	-0.6	-0.7	0.3	2.5	2.0	0.2	0.3	2.2
Sensitivity / hurt feelings	2.1	3.5	9.3	2.6	3.0	1.0	1.6	2.8	0.6	1.7	-0.7	1.1	1.7
Frequency of depressed mood in last 2 weeks	2.3	3.2	10.8	-0.5	-0.8	-1.0	-0.9	-0.6	3.3	3.0	-0.4	0.4	2.9
Hearing difficulty/problems: Yes	0.7	1.0	4.2	-1.3	-0.5	-2.1	-0.8	0.4	-0.7	-0.1	-0.6	-1.5	-0.1
Relative age of first facial hair	0.7	1.5	4.4	-1.5	-0.3	-1.1	-0.9	-0.5	0.8	2.1	-0.3	0.9	2.0
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.6	-1.0	0.2	-1.6	-1.5	-0.6	-0.1	1.3	0.6	-0.2	1.4
Ever used hormone-replacement therapy (HRT)	2.6	3.3	6.4	2.5	2.5	1.9	2.0	2.4	-0.3	-0.5	1.4	-2.2	-0.6
Ever had hysterectomy (womb removed)	0.8	0.9	3.4	-1.3	-0.6	-1.2	-0.9	0.1	1.0	-0.4	1.8	-0.2	-0.2
Systolic blood pressure, automated reading	1.0	2.8	5.4	2.3	2.1	2.0	2.3	2.3	0.5	0.7	-1.5	-0.3	0.9
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	2.0	-0.3	0.1	0.1	-0.5	-0.7	1.4	1.0	-0.7	0.5	1.1
Angina	1.7	2.2	7.0	-0.1	-1.4	-0.8	-1.0	-1.3	-0.8	-1.9	1.4	-2.7	-1.9
Medication for hormone replacement therapy	2.7	3.0	8.6	2.0	2.1	2.9	2.6	1.5	0.3	-1.1	1.1	0.3	-1.1
Vitamin and mineral supplements	0.6	0.8	2.4	-0.5	-0.4	-0.6	-0.9	-1.1	0.1	1.5	-0.8	0.2	1.5
Supplements: Zinc	0.9	0.9	3.0	-0.1	-1.2	-0.2	-0.3	0.9	-1.7	-1.5	-0.1	0.4	-1.3
Medication: Co-codamol	1.7	2.0	4.2	-1.3	-1.6	-2.0	-1.9	-2.0	0.3	0.9	-1.1	-0.9	0.9
Medication: Metformin	0.8	1.1	4.3	-0.3	-0.2	-0.4	-1.1	-1.7	2.1	-1.1	0.2	0.0	-1.1
Diabetes (father)	1.1	1.3	6.6	1.2	0.0	1.3	0.6	-0.0	2.6	0.8	-0.5	-1.1	1.0
Diabetes (mother)	1.5	1.9	9.0	-1.4	-1.2	-0.6	-1.8	-3.0	-1.4	-0.7	-0.4	-0.6	-0.6
Severe depression (siblings)	0.6	0.7	2.0	1.4	0.8	0.6	0.5	-0.2	0.1	1.2	-0.0	0.8	1.1
Pack years adult smoking proportion	1.3	2.0	6.4	-0.9	0.2	-0.6	-0.4	-0.5	1.6	2.5	-0.5	1.9	2.5
Impedance of leg (right)	0.4	2.2	3.8	2.0	1.9	1.9	1.5	0.8	-2.0	-1.0	-1.2	-0.7	-1.0
Leg fat-free mass (left)	0.6	3.4	11.2	-1.1	-1.5	-0.8	-0.7	-0.9	2.0	3.3	-0.1	1.8	3.2
Trunk fat percentage	0.5	2.0	5.8	0.7	-0.0	0.6	0.5	0.7	2.4	2.2	-1.2	0.5	2.4
Hand grip strength (right)	1.6	4.4	9.0	2.0	1.6	2.0	2.0	0.8	0.3	3.0	-2.4	2.2	3.0
Townsend deprivation index at recruitment	0.3	0.4	1.1	0.3	0.5	0.3	0.1	-0.5	-0.1	1.0	-0.5	1.0	0.9
Current tobacco smoking	0.4	0.6	2.5	0.1	0.4	-0.0	0.0	-0.0	0.6	1.5	0.1	0.7	1.6
Average weekly fortified wine intake	0.2	0.2	0.6	0.2	-0.0	0.8	0.6	0.3	-0.6	-0.4	0.7	-0.4	-0.3
Maternal smoking around birth	1.0	1.5	4.9	0.8	0.4	0.4	0.7	0.7	0.4	2.2	-0.2	1.8	2.2
Fed-up feelings	0.7	1.4	4.2	0.1	-0.5	-0.6	0.0	1.1	1.1	2.1	-1.3	-0.9	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	8.0	-0.8	-0.8	-1.0	-1.5	-1.4	1.8	2.8	0.6	0.2	2.5
Relative age voice broke	0.2	0.3	1.0	-0.4	-0.3	-0.2	-0.5	-0.4	0.5	-0.5	-1.0	-0.2	-0.6
Taking other prescription medications	1.3	2.0	5.0	-1.5	-1.6	-1.9	-1.6	-0.1	0.2	-0.1	1.9	-2.2	-0.1
Age when periods started (menarche)	0.7	1.6	5.6	0.5	2.4	0.4	1.1	1.2	1.1	0.7	1.3	1.8	0.7
Bilateral oophorectomy (both ovaries removed)	1.7	2.0	4.8	-2.2	-1.6	-2.0	-1.9	-0.4	-0.0	1.0	0.6	-1.5	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	4.5	-0.2	-2.0	1.1	0.7	-1.3	-0.2	-2.1	-1.4	-0.0	-2.1
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	4.4	0.1	-0.9	-0.1	-0.5	-0.2	-2.1	-0.7	-0.3	-1.4	-0.8
Qualifications: CSEs or equivalent	0.4	0.6	3.0	-0.2	0.2	0.3	-0.3	-0.8	0.4	0.7	0.8	1.7	0.7
Serious illness, injury or assault to yourself	0.9	1.1	3.4	-0.4	-0.6	0.3	-0.6	-1.4	1.8	0.8	1.7	-0.5	0.7
High blood pressure	0.2	0.6	3.3	0.4	0.5	-0.3	-0.3	-0.2	1.8	0.1	1.3	-0.8	0.2
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.9	-0.9	-0.8	-0.4	-0.8	-1.2	-1.3	-0.2	-1.4	1.3	-0.3
Multivitamins +/- minerals	0.9	1.1	2.2	0.9	0.6	1.4	1.5	1.3	-0.8	-1.3	0.1	0.0	-1.3
Stomach or abdominal pain in last month	0.6	0.8	2.8	0.1	0.7	0.7	0.4	0.1	-0.8	1.6	0.5	0.5	1.7
Supplements: Glucosamine	0.2	0.3	0.9	0.7	0.1	0.2	0.3	0.4	-0.3	-0.9	0.3	0.2	-0.9
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	3.3	-0.3	-0.8	-1.2	-0.9	0.1	1.8	0.3	1.2	-1.0	0.2
Medication: Atenolol	1.1	1.4	3.9	-0.5	-1.6	-1.9	-2.0	-0.9	0.5	0.0	-1.3	-1.0	0.0
Medication: Levothyroxine sodium	0.4	0.7	2.3	0.4	0.2	-0.2	-0.1	0.5	-0.9	-0.9	1.5	-1.2	-1.0
Sitting height	0.5	3.7	14.1	-0.2	-0.0	0.1	0.6	1.0	0.2	3.8	-2.2	1.8	3.6
Chronic bronchitis/emphysema (father)	0.5	0.6	2.8	0.2	-0.5	-0.2	-0.0	0.5	-0.3	-0.8	1.7	-1.0	-0.6
High blood pressure (mother)	0.5	0.7	1.6	1.3	0.8	1.0	0.8	0.1	-1.1	-0.7	0.5	-0.8	-0.8
Body mass index (BMI)	0.8	3.5	10.1	-0.9	-1.6	-1.1	-1.1	-0.4	3.2	3.0	0.0	0.5	3.1
Impedance of leg (left)	0.5	2.4	5.4	2.0	2.3	1.9	1.6	1.1	-1.6	-1.3	-1.1	-0.6	-1.2
Leg predicted mass (left)	0.7	3.5	11.3	-1.2	-1.6	-0.8	-0.8	-0.9	2.0	3.4	-0.2	1.8	3.2
Trunk fat mass	0.7	2.8	10.0	0.4	-0.3	0.3	0.2	0.4	2.5	3.0	-1.2	0.7	3.2
Waist circumference	0.7	2.4	9.4	-0.1	-0.2	-0.7	-0.4	0.3	3.1	2.6	0.6	0.3	2.6
Number of incorrect matches in round	0.3	0.5	2.9	0.4	0.2	-0.4	-0.3	0.7	-1.7	-0.4	-0.6	0.6	-0.3
Past tobacco smoking	0.1	0.2	0.5	-0.7	0.2	-0.6	-0.6	0.0	0.5	0.1	-0.6	0.7	0.3
Alcohol usually taken with meals	0.7	1.2	3.3	0.1	0.3	-0.0	0.4	0.5	0.5	-1.7	1.5	-1.6	-1.8
Nervous feelings	0.4	0.7	2.2	0.3	0.9	0.4	0.7	1.5	-1.4	0.7	0.1	-0.2	0.8
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	7.9	0.2	0.3	-0.5	-0.5	-0.1	2.8	1.9	0.6	-0.2	1.8
Hearing difficulty/problems with background noise	0.4	0.7	2.8	0.5	0.5	0.1	0.7	1.7	1.0	0.7	0.7	0.6	0.8
Hair/balding pattern: Pattern 2	0.7	0.9	4.1	-0.6	-1.4	-0.6	-0.9	-0.2	0.7	0.3	2.0	-0.3	0.5
Had menopause	2.1	2.6	7.9	0.4	-0.0	-0.1	0.5	1.7	0.7	-2.8	1.5	-2.3	-2.6
Had other major operations	1.4	1.8	4.8	-1.3	-1.0	-1.8	-1.5	-0.3	1.8	0.9	2.2	-0.2	0.8
Forced vital capacity (FVC)	0.5	2.1	6.2	-0.7	-0.0	-0.1	-0.0	0.5	-1.0	2.4	-1.2	2.5	2.4
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.5	3.1	-0.1	-1.8	0.8	0.7	-1.5	-0.0	-1.7	-1.6	0.0	-1.6
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.4	-0.1	0.1	-0.8	-0.5	0.1	1.6	1.2	0.9	0.3	1.2
Qualifications: None of the above	0.7	1.4	3.6	-1.1	-0.5	-1.7	-1.9	-0.6	0.2	1.6	0.6	-0.6	1.7
Financial difficulties in last 2 years	2.4	3.2	8.4	-0.8	-0.2	-1.5	-1.5	-0.7	2.0	2.5	-1.4	2.9	2.4
Mouth/teeth dental problems	0.3	0.5	1.8	-0.4	-0.5	-0.4	-0.8	-0.5	1.2	-0.3	-1.3	0.6	-0.2
Heart attack	0.2	0.3	1.1	0.6	0.1	0.3	0.3	-0.0	-0.4	0.6	-1.0	-0.4	0.6
Allergy	0.3	0.7	2.7	0.7	0.5	0.4	0.3	0.2	-0.2	-1.3	0.4	-1.7	-1.1
Pain all over the body in last month	1.7	1.8	4.3	1.8	2.1	1.3	1.5	1.8	0.4	-0.6	1.0	-1.0	-0.7
Diabetes (self-reported)	0.6	0.9	2.7	0.0	-0.8	-0.5	-0.4	-0.0	-0.1	-1.7	-0.3	-1.5	-1.6
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.3	0.7	1.0	0.5	0.5	0.3	-1.5	0.1	-1.4	1.2	0.2
Medication: Ramipril	1.5	2.0	8.0	1.2	1.3	1.0	1.5	1.4	2.8	0.5	-1.6	-0.5	0.4
Medication: Simvastatin	0.4	0.6	1.8	0.8	0.9	0.2	0.5	1.0	-0.1	-1.0	-0.1	-1.3	-0.9
Fluid intelligence score	0.2	0.4	1.6	0.4	-0.0	0.5	0.6	0.3	0.6	-0.5	-1.3	0.9	-0.5
Illnesses of siblings	0.4	0.5	1.7	-1.1	-0.2	-0.6	-0.4	0.1	0.6	-0.1	1.3	1.1	-0.2
Neuroticism score	0.9	1.8	7.0	0.1	-0.1	-1.1	-0.4	1.4	1.0	2.6	0.0	-0.7	2.6
Weight	0.9	4.5	15.7	-0.8	-1.3	-0.7	-0.7	-0.4	3.0	4.0	-0.6	1.1	3.9
Impedance of arm (right)	0.7	3.2	7.3	2.2	2.7	2.7	2.3	1.0	-1.0	-1.6	-0.4	-0.4	-1.6
Arm fat percentage (right)	0.7	2.8	11.4	0.6	0.1	0.4	0.5	0.7	3.4	2.6	-0.6	0.4	2.8
Trunk fat-free mass	0.8	4.3	16.3	-1.4	-1.2	-1.3	-0.9	-0.5	1.6	4.0	-0.2	1.7	3.9
Hip circumference	0.5	1.9	7.3	0.2	-0.5	0.0	0.2	0.6	1.8	2.6	-0.1	1.0	2.7
Time employed in main current job	1.2	1.4	4.6	1.5	1.6	0.4	1.1	2.1	-1.8	-0.2	-0.3	0.1	-0.1
Alcohol intake versus 10 years previously	1.8	2.8	7.6	-0.9	-0.7	-0.7	-0.8	-1.5	-0.7	-2.6	1.0	-2.8	-2.6
Father’s age at death	2.0	2.6	6.5	-0.9	-1.4	-1.2	-1.0	-0.2	-2.1	-2.1	2.5	-1.0	-2.2
Worrier / anxious feelings	1.0	1.9	5.5	0.6	0.4	-0.5	0.4	2.3	0.7	2.0	0.7	-1.8	2.0
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	6.0	1.3	1.4	1.3	0.9	-0.1	0.9	2.4	-0.1	1.1	2.4
Falls in the last year	0.7	0.9	3.9	-0.3	0.4	-0.4	-0.7	0.3	0.3	2.0	-0.0	0.9	1.8
Hair/balding pattern: Pattern 3	1.4	2.1	3.9	1.5	1.9	1.8	1.8	1.9	-0.9	-0.1	-0.3	2.0	-0.1
Number of live births	0.8	1.1	3.0	-0.0	0.3	0.5	0.5	0.8	1.6	1.7	-1.0	0.4	1.7
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	3.8	-0.6	-0.1	-0.1	-0.1	-0.0	-0.8	1.9	-0.8	1.9	1.8
Pulse rate	1.9	3.2	8.0	-2.5	-2.0	-2.4	-2.8	-2.5	0.0	-0.7	0.9	-0.5	-0.8
Happiness	0.7	0.8	2.1	0.9	0.5	1.4	1.4	1.4	-0.3	-0.5	-0.6	0.6	-0.6
Noisy workplace	0.5	0.6	3.4	0.0	0.3	-0.2	-0.4	-0.2	-1.8	-0.7	-1.2	0.3	-0.7
Qualifications: A levels/AS levels or equivalent	0.8	1.7	3.9	-1.7	-0.6	-0.9	-1.2	-2.0	-1.6	-1.2	-0.6	-0.9	-1.4
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.9	2.8	-0.6	0.0	-0.5	-0.4	-0.5	0.9	1.7	-1.0	-0.9	1.5
Mouth/teeth dental problems: Dentures	0.6	1.0	3.4	0.1	0.3	-0.2	0.2	0.9	-1.8	-0.1	1.8	-1.6	-0.1
Asthma	0.6	1.1	5.2	0.5	0.4	0.1	0.2	0.5	0.2	1.7	0.3	2.3	1.6
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	4.4	-1.5	-1.1	-0.6	-1.2	-1.8	-1.5	-1.1	2.1	-1.2	-1.1
Medication: Cholesterol lowering	0.5	0.7	4.0	0.9	-0.3	-0.1	-0.1	-0.2	-0.1	-1.1	0.3	-2.0	-1.0
Depression (self-reported)	1.1	1.3	4.5	1.1	1.0	-0.2	0.6	1.4	-0.5	2.1	-0.3	0.2	2.0
Medication: Lansoprazole	1.3	1.5	4.8	-1.1	-0.9	-1.6	-0.7	1.3	0.5	0.6	2.2	-1.6	0.7
Prospective memory result	0.3	0.4	2.9	-0.3	-0.0	0.0	-0.4	-0.5	0.1	0.7	-1.7	-0.1	0.6
Lung cancer (father)	0.9	1.0	3.4	0.9	0.8	1.5	1.8	0.4	-0.3	-0.7	1.4	0.5	-0.6
Illnesses of mother	0.3	0.4	1.1	-0.2	-0.2	-0.2	0.2	0.3	0.8	0.8	-0.8	1.0	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	3.0	-0.3	-0.2	0.1	0.1	0.1	-1.2	1.7	-1.4	1.3	1.7
Pulse wave Arterial Stiffness index	0.5	0.6	1.7	-1.0	-0.3	-0.5	-1.3	-1.3	0.8	-0.0	-0.4	-0.7	-0.0
Impedance of arm (left)	0.5	2.1	4.3	1.6	2.1	1.9	1.6	0.6	-0.4	-1.9	-0.7	-0.5	-1.9
Arm fat mass (right)	0.8	3.5	11.7	-0.3	-0.8	-0.3	-0.3	-0.0	3.2	3.3	-0.5	0.7	3.4
Trunk predicted mass	0.7	4.2	16.2	-1.3	-1.1	-1.2	-0.8	-0.4	1.6	4.0	-0.2	1.8	3.9
Standing height	0.2	1.9	7.3	-0.1	0.3	0.5	0.7	-0.1	-0.2	2.7	-1.5	1.4	2.5
Length of working week for main job	1.8	2.0	7.0	0.3	0.3	1.3	0.3	-1.4	-0.3	2.6	-0.3	1.4	2.7
Exposure to tobacco smoke at home	0.9	1.0	3.0	-0.9	-1.6	-0.7	-1.4	-1.7	0.6	0.6	-0.5	-0.4	0.5
Breastfed as a baby	2.4	2.9	6.1	-2.0	-2.5	-1.9	-2.1	-1.2	-1.0	-1.0	-0.7	-2.4	-1.0
Tense / ‘highly strung’	1.4	2.3	7.4	0.8	1.0	-0.3	0.3	2.0	0.1	2.7	-1.4	-0.1	2.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.8	5.8	-1.5	-1.6	-2.3	-2.1	-0.4	0.7	2.4	0.6	-1.0	2.3
Hair/balding pattern: Pattern 4	0.1	0.3	1.9	0.2	0.3	-0.1	-0.0	-0.8	-0.0	0.1	-1.4	-0.3	-0.0
Birth weight of first child	1.3	2.4	10.5	-1.3	-1.6	-1.5	-1.8	-1.2	0.0	-0.5	3.2	-1.3	-0.6
Peak expiratory flow (PEF)	0.7	1.5	5.9	-0.2	-0.3	0.3	-0.2	-0.8	0.0	2.4	-0.1	1.7	2.3
Pulse wave reflection index	0.4	0.4	1.1	0.8	0.5	1.0	0.8	0.3	-0.7	-0.6	-0.0	-0.7	-0.7
Ever highly irritable/argumentative for 2 days	0.3	0.4	2.1	0.5	0.0	0.8	0.8	0.5	0.2	0.2	-0.3	-1.4	0.2
Loud music exposure frequency	1.4	1.5	3.9	-1.9	-1.5	-1.8	-1.2	-0.7	0.2	0.3	-2.0	-0.0	0.3
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.8	-0.6	-0.6	-0.3	-0.1	0.0	-0.3	-1.2	-0.3	-0.4	-1.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.8	0.4	0.5	0.5	0.4	-0.6	-0.9	0.7	-0.9	0.2	0.6
Blood clot in the leg (DVT)	1.2	1.6	4.9	-1.4	-1.8	-1.2	-1.4	-0.7	2.2	0.4	0.8	-1.0	0.4
Medication: Paracetamol	2.2	3.6	6.9	-2.1	-0.9	-1.0	-2.1	-2.1	2.6	2.4	0.2	1.5	2.4
Headache pain in last month	2.0	3.4	13.4	-0.7	0.2	-0.8	-0.8	-0.4	-0.2	3.5	0.5	2.3	3.7
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	3.8	-1.0	0.4	0.1	0.2	0.0	-0.4	1.1	-1.4	1.9	1.0
Glaucoma (self-reported)	0.3	0.3	0.7	0.7	0.2	0.8	0.3	0.0	0.7	0.7	-0.0	0.6	0.6
Gout (self-reported)	0.3	0.4	0.9	-0.4	0.1	0.6	0.3	0.0	0.7	-0.9	0.1	-0.8	-1.0
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.6	-1.0	-0.7	-1.6	-1.3	-0.2	-1.4	-0.1	1.2	-1.3	-0.1
Medication: Amlodipine	0.6	0.9	3.8	-0.4	-0.8	0.0	-0.5	-1.0	0.8	-1.0	-0.6	-1.9	-0.9
Medication: Ventolin 100micrograms inhaler	0.4	0.6	3.0	0.0	0.1	0.1	0.1	-0.2	-1.3	0.7	-1.7	0.6	0.5
Birth weight	0.7	1.6	3.3	-1.7	-1.8	-1.5	-1.6	-1.1	0.1	-0.3	1.0	-1.6	-0.6
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.2	-0.6	-0.5	-1.1	-0.8	0.7	-0.5	0.0	-0.7	0.3	0.1
High blood pressure (siblings)	0.6	0.9	1.7	1.3	0.9	1.0	1.3	1.2	-0.0	0.9	0.3	-0.7	0.9
Forced vital capacity (FVC), Best measure	0.6	2.1	5.5	-0.2	0.0	0.1	0.3	0.7	-1.8	2.4	-1.8	1.6	2.4
Body fat percentage	0.6	2.4	8.4	0.6	-0.3	0.2	0.2	0.7	2.9	2.5	-1.1	0.2	2.7
Leg fat percentage (right)	0.7	2.4	8.6	0.4	-0.9	-0.2	-0.3	0.2	2.4	2.8	-0.7	-0.1	2.9
Arm fat-free mass (right)	0.8	3.9	13.1	-1.4	-1.6	-1.5	-1.1	-0.6	1.7	3.6	-0.5	1.5	3.5
Exposure to tobacco smoke outside home	1.0	1.3	2.7	-1.5	-1.1	-0.9	-1.0	-1.3	1.6	-1.2	0.1	0.6	-1.2
Comparative body size at age 10	1.2	3.3	11.4	-2.1	-2.4	-2.3	-2.2	-1.0	3.4	-0.4	0.5	-0.4	-0.4
Number of full brothers	1.1	1.4	3.8	-1.4	-1.4	-0.7	-0.7	0.4	-1.0	1.9	0.7	-0.4	1.9
Worry too long after embarrassment	0.9	1.4	3.4	1.4	1.1	0.8	1.3	0.8	1.4	1.9	-0.0	0.1	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	3.4	-0.9	-0.9	-1.9	-1.6	-0.7	-0.4	1.5	0.1	-0.3	1.5
Wheeze or whistling in the chest in last year	1.1	2.0	5.9	2.0	1.5	1.8	1.4	1.4	-0.2	0.8	0.2	2.4	0.7
Number of children fathered	0.2	0.3	0.7	-0.2	-0.4	0.0	-0.2	-0.7	-0.8	0.7	0.3	-0.3	0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	4.0	-1.0	-0.7	-0.9	-1.8	-1.1	-2.0	-0.7	-0.3	-1.1	-0.7
Age at first live birth	0.4	0.7	3.2	0.6	0.0	0.3	0.4	0.1	0.5	-1.7	-0.4	-0.2	-1.8
Pulse wave peak to peak time	0.5	0.6	1.7	0.9	0.3	0.6	1.3	1.3	-0.7	0.2	0.2	0.9	0.2
Health satisfaction	0.9	1.2	3.1	-1.2	-0.6	-1.8	-1.1	0.5	0.4	1.4	-0.5	-1.0	1.4
Shortness of breath walking on level ground	0.8	0.9	3.0	0.6	0.7	-0.1	0.1	0.6	1.7	1.5	-0.5	0.0	1.5
Qualifications: College or University degree	0.2	0.8	2.4	0.1	-1.0	1.0	0.8	-0.4	-0.8	-1.4	0.2	-0.2	-1.6
Eye problems/disorders: None of the above	0.8	0.9	2.8	1.1	0.8	0.9	1.1	1.3	-0.6	0.5	0.1	1.7	0.4
Mouth/teeth dental problems: Loose teeth	0.4	0.4	1.5	0.5	0.4	0.2	0.2	0.4	1.0	0.7	1.2	0.2	0.6
Emphysema/chronic bronchitis	0.2	0.2	1.5	-0.1	0.6	-0.2	0.3	0.0	-0.2	-0.3	1.2	0.3	-0.4
Medication for pain relief, constipation, heartburn	0.7	1.2	2.2	1.2	1.2	1.0	1.5	1.3	-1.2	-0.5	-1.1	1.0	-0.5
Neck or shoulder pain in last month	0.8	1.2	4.9	-0.6	0.1	-0.6	0.0	0.9	-0.0	2.2	-0.8	-0.5	2.2
Medication: Blood pressure	0.6	1.0	3.3	1.5	0.5	0.8	0.8	0.8	0.4	-0.8	1.2	-1.8	-0.6
Angina (self-reported)	1.9	2.6	7.7	-0.1	-1.5	-0.8	-1.0	-1.3	-0.9	-2.1	1.6	-2.8	-2.1
Migraine (self-reported)	0.5	0.6	2.3	-1.5	-0.8	-0.8	-0.8	-0.3	0.9	0.6	-0.4	0.4	0.7
Medication: Ibuprofen	0.7	0.9	2.2	-1.1	-0.6	-0.5	-0.9	-1.0	-1.3	-0.5	1.5	-0.7	-0.5
Medication: Allopurinol	0.3	0.3	0.9	-0.8	0.2	-0.1	-0.4	0.3	-0.5	-1.0	-0.5	0.5	-0.9
Medication: Omeprazole	0.7	0.8	2.2	-0.7	0.1	-1.2	-0.6	0.0	-0.4	-1.5	0.7	-0.7	-1.5
Medication: Seretide 50 evohaler	0.7	0.8	1.5	1.1	1.0	0.9	0.9	1.2	-0.1	0.9	1.2	-0.2	0.6
Mean time to correctly identify matches	1.0	1.9	4.7	0.6	1.5	0.1	0.7	1.9	2.1	0.9	2.2	-1.2	0.9
Heart disease (mother)	0.3	0.4	2.0	0.3	-0.4	0.1	0.2	0.4	0.6	0.7	-1.4	0.5	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.5	2.2	0.0	1.0	0.3	0.9	1.5	-0.7	0.3	-0.7	-0.4	0.2
Whole body fat mass	0.7	2.9	9.6	0.1	-0.7	-0.1	-0.1	0.2	3.1	2.9	-0.9	0.5	3.1
Leg fat mass (right)	0.8	3.0	10.9	0.3	-0.8	0.1	-0.1	0.2	2.8	3.2	-0.5	0.4	3.3
Arm predicted mass (right)	0.7	3.7	11.9	-1.4	-1.7	-1.4	-1.2	-0.7	1.6	3.5	-0.3	1.6	3.3
Pulse rate, automated reading	1.6	5.1	13.0	-3.3	-2.5	-3.4	-3.6	-2.5	-0.5	-0.4	1.7	0.3	-0.5
Alcohol intake frequency.	0.4	1.0	4.1	1.0	2.0	1.5	1.0	1.0	0.2	0.2	0.1	0.8	0.4
Comparative height size at age 10	0.1	0.4	1.3	-0.3	-0.3	-0.2	0.1	0.5	0.3	1.1	-1.2	0.6	0.9
Number of full sisters	0.2	0.3	1.1	-0.5	0.5	0.1	0.2	0.5	-0.7	1.0	-0.2	-0.1	0.8
Suffer from ‘nerves’	0.4	0.6	2.1	-0.7	-0.2	-1.5	-0.7	1.2	-0.8	0.2	0.2	-0.9	0.1
Overall health rating	1.4	2.9	9.9	0.4	1.2	-0.3	-0.2	0.6	3.1	2.9	-0.1	-0.3	3.0
Chest pain or discomfort	0.7	1.0	2.6	1.6	1.0	1.2	0.8	0.3	-0.2	1.5	-0.0	0.0	1.3
Had major operations	0.4	0.5	2.6	-0.1	0.1	0.1	0.1	-0.0	0.3	0.9	-0.7	1.6	0.9
Age at last live birth	1.0	1.4	4.3	1.0	0.3	0.5	0.9	0.5	1.5	-2.0	-0.7	-0.6	-2.1
Family relationship satisfaction	0.9	1.1	3.3	-0.4	-0.2	-1.0	-1.0	-0.5	0.8	1.8	-0.3	1.0	1.8
Leg pain on walking	0.8	1.0	3.3	-1.0	-0.5	-1.4	-1.8	-1.4	-0.6	0.1	-0.1	-1.0	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	3.1	0.6	0.3	0.9	0.6	0.3	-0.4	1.7	-0.8	1.2	1.8
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.8	-0.1	-1.2	-0.7	-0.7	-0.2	-1.3	1.3	0.0	0.2	1.4
Illness, injury, bereavement, stress in last 2 years	1.7	2.1	5.1	0.9	0.9	0.9	1.4	1.7	-2.2	-2.0	-0.1	-1.1	-1.9
Medication: Aspirin	0.6	0.8	2.2	1.1	0.3	0.2	0.8	1.1	1.4	0.2	-0.7	-1.5	0.3
Supplements: Vitamin C	1.6	1.9	3.6	1.6	0.4	1.5	1.7	1.9	0.4	-1.9	0.5	-0.7	-1.7
Knee pain experienced in last month	1.1	1.8	9.5	-1.1	-0.7	-1.4	-1.3	-0.6	1.3	0.2	3.1	-0.8	0.1
Hypertension (Self-reported)	0.2	0.7	3.1	0.3	0.3	-0.6	-0.4	-0.3	1.8	-0.2	1.0	-1.4	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.2	4.0	-1.0	0.5	-0.5	-0.2	1.0	0.8	1.5	-0.6	2.0	1.6
Illnesses of father: Heart disease	1.7	2.3	6.2	-1.9	-1.8	-1.4	-1.9	-1.8	0.9	-0.5	0.2	-2.5	-0.5
Illnesses of siblings: Diabetes	1.0	1.2	5.4	0.4	0.2	0.4	0.0	0.2	-1.7	1.2	-2.3	0.2	1.3
Smoking status: Previous	0.3	0.4	1.6	1.1	0.0	1.3	1.0	-0.1	-0.3	-0.1	-0.1	-0.4	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	4.8	-1.2	-0.5	-0.1	-0.2	-1.1	0.1	2.2	-1.2	1.6	2.1
Whole body fat-free mass	0.7	4.2	15.1	-1.4	-1.4	-1.1	-0.8	-0.7	1.7	3.9	-0.3	2.0	3.7
Leg fat-free mass (right)	0.6	3.0	9.1	-1.2	-1.4	-0.8	-0.7	-0.8	2.0	3.0	-0.1	1.9	2.9
Arm fat percentage (left)	0.7	2.8	13.2	0.3	-0.1	0.1	0.2	0.5	3.6	2.5	-0.8	0.4	2.7
Average weekly red wine intake	1.1	1.6	4.2	1.6	1.6	1.9	2.1	1.2	0.3	-0.7	0.0	-0.3	-0.8
Handedness (chirality/laterality): Left-handed	1.2	1.4	6.5	0.9	0.8	1.1	1.2	0.8	1.0	0.9	-2.5	-0.1	1.0
Mood swings	1.9	3.4	6.2	-1.9	-2.4	-2.5	-2.4	-1.6	0.7	2.1	-0.1	-1.3	1.9
Loneliness, isolation	0.6	0.8	1.5	-1.0	-0.5	-1.0	-0.6	0.4	1.2	1.1	0.6	1.1	1.0
Long-standing illness, disability or infirmity	0.2	0.4	1.0	-0.8	0.1	-0.9	-0.6	-0.0	0.4	0.4	1.0	-0.5	0.5
Ever had bowel cancer screening	0.2	0.3	0.7	-0.6	-0.4	-0.5	-0.4	0.3	0.6	-0.3	0.8	-0.7	-0.2
Diabetes diagnosed by doctor	0.2	0.4	1.1	0.2	-0.4	-0.5	-0.4	-0.2	0.5	-0.9	-0.5	-1.1	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	2.7	2.9	11.2	0.4	0.8	0.2	0.5	0.5	1.9	3.3	-0.3	1.5	3.3
Friendships satisfaction	0.5	0.6	1.9	-0.3	0.2	0.2	0.1	0.7	-0.1	1.0	-1.2	1.4	1.1
Qualifications: nursing, teaching	0.7	1.1	3.1	-0.9	-1.0	-1.2	-1.3	-1.5	1.8	-0.4	0.1	0.2	-0.4
Commuting to job workplace: Walk	1.7	1.8	5.2	0.6	2.3	1.3	1.6	1.2	1.8	-0.9	-0.1	1.3	-0.9
Eye problems/disorders: Cataract	0.4	0.5	1.7	-1.3	-0.8	-0.3	-0.5	-0.8	-0.4	-0.1	-0.5	-1.1	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	3.1	-1.5	-1.7	-0.1	-0.5	-1.2	-0.6	0.0	-0.1	-1.0	-0.0
Medication for cholesterol	0.8	1.3	3.2	-1.4	-1.5	-0.8	-1.4	-1.8	-1.4	0.4	-0.4	-0.7	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.2	-1.1	-0.6	-1.1	-0.9	0.2	-0.9	0.1	-0.4	-0.8	0.1
Back pain experienced in last month	0.8	1.1	1.9	-1.1	-0.9	-0.9	-1.3	-1.4	0.4	0.9	-1.4	-0.7	1.0
Mineral and other dietary supplements	1.7	2.3	5.8	-1.6	-0.7	-1.6	-1.7	-1.3	1.2	2.4	-0.5	0.3	2.4
Breast cancer (self-reported)	0.3	0.4	1.2	-0.6	-1.1	0.2	-0.6	-0.4	-0.0	0.5	0.9	0.0	0.7
Asthma (self-reported)	0.6	1.2	4.6	0.8	0.7	0.4	0.4	0.6	0.4	1.8	0.2	2.2	1.6
Osteoporosis (self-reported)	1.6	2.0	2.6	1.4	1.5	1.0	1.6	1.3	-1.5	-1.6	1.0	-1.6	-1.5
Osteoarthritis (self-reported)	2.6	3.4	5.9	-1.5	-2.0	-2.4	-2.4	-1.8	2.3	1.9	0.6	0.1	1.8
Medication: Aspirin	0.5	0.7	2.1	0.9	0.1	0.4	0.8	1.0	1.2	-0.1	-0.7	-1.5	0.0
Medication: Gliclazide	1.2	1.3	4.4	0.1	0.5	0.1	0.2	-0.4	1.4	-2.1	1.3	-0.6	-2.1
Illnesses of father: None of the above (group 1)	1.2	1.5	4.8	0.7	1.4	0.4	1.3	2.0	-0.7	0.8	0.7	2.2	0.7
Smoking status: Current	0.2	0.2	0.7	-0.0	0.2	-0.1	-0.2	-0.4	0.8	0.7	0.6	0.1	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	1.0	-0.6	-0.6	-0.2	-0.3	-0.3	-0.6	0.5	-0.0	1.0	0.7
Whole body water mass	0.7	4.3	15.8	-1.4	-1.4	-1.1	-0.8	-0.5	1.8	4.0	-0.3	1.9	3.8
Leg predicted mass (right)	0.6	3.0	9.1	-1.2	-1.4	-0.8	-0.7	-0.8	2.0	3.0	0.0	1.9	2.9
Arm fat mass (left)	0.9	3.7	13.0	-0.4	-0.9	-0.3	-0.3	0.1	3.6	3.3	-0.5	0.7	3.4
Number of self-reported non-cancer illnesses	1.4	2.4	4.4	-1.5	-0.9	-2.1	-1.8	-1.1	2.0	1.8	0.8	-0.7	1.9
Average weekly champagne plus white wine intake	0.6	0.9	3.1	0.3	-0.1	-0.7	0.1	1.4	0.1	1.8	-0.1	-0.4	1.7
Miserableness	1.6	2.8	6.2	-1.5	-2.5	-1.7	-1.7	-0.9	1.3	2.3	0.7	-0.4	2.2
Guilty feelings	0.4	0.7	2.1	0.3	-0.9	-0.1	-0.2	-0.2	0.1	1.4	1.1	-0.6	1.4
Wears glasses or contact lenses	0.6	0.7	3.3	0.2	0.2	-0.7	0.0	1.8	0.8	0.1	-0.3	-1.7	0.2
Ever taken oral contraceptive pill	1.8	2.0	5.4	0.7	1.3	1.2	1.2	-0.0	-0.2	2.3	-1.1	1.7	2.3
Hearing aid user	1.5	1.7	5.3	0.8	1.4	-0.5	0.8	2.3	-1.6	1.1	-1.4	1.1	1.0
Mother’s age at death	3.8	4.7	12.6	-0.3	-1.3	0.6	-0.1	-1.6	-3.1	-3.5	1.8	-2.1	-3.5
Financial situation satisfaction	1.5	1.8	5.0	-0.2	0.2	-0.9	-0.8	0.4	2.2	2.1	0.6	1.5	2.1
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.6	-0.3	-1.0	-0.2	-0.6	-0.5	0.6	-0.5	-1.6	0.8	-0.5
Commuting to job workplace: Public transport	1.3	1.5	3.4	-0.5	-0.5	-0.3	-0.6	-1.6	1.7	-1.7	1.3	-0.6	-1.8
Eye problems/disorders: Glaucoma	0.3	0.3	0.6	0.7	-0.1	0.7	0.3	-0.5	-0.4	-0.6	0.4	-0.8	-0.7
Medication: Blood pressure	1.1	2.0	7.1	-1.2	-1.2	-2.7	-1.9	-0.9	2.2	0.1	0.7	-0.6	-0.1
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.4	-1.0	-0.6	-1.2	-0.9	0.6	0.4	-0.3	0.2	0.8	-0.1
Supplements: Fish oil (including cod liver oil)	2.2	2.9	5.1	2.2	1.1	2.2	2.0	1.8	-1.4	-2.0	0.6	-0.9	-1.9
High cholesterol (Self-reported)	0.5	0.9	3.6	1.1	1.0	0.5	0.8	1.9	1.2	-0.2	-0.6	0.4	-0.1
Medication: Bendroflumethiazide	2.7	4.0	10.8	-2.5	-2.5	-3.3	-3.0	-2.0	-0.2	0.9	1.5	-0.3	0.8
Medication: Paracetamol	2.3	3.5	10.4	-2.0	-1.1	-1.2	-2.1	-2.0	3.2	2.0	0.4	1.3	2.0
Medication: Lisinopril	1.3	1.7	4.0	-1.4	-2.0	-1.9	-1.7	-0.5	-1.2	-0.3	-0.6	-1.5	-0.3
Medication: Atorvastatin	0.7	0.9	2.9	-0.7	-1.7	-1.1	-1.4	-1.4	-0.0	-0.3	-0.3	0.2	-0.3
Illnesses of father: High blood pressure	1.2	1.5	4.3	1.2	0.3	1.6	0.9	-0.4	1.8	0.7	-2.1	-1.1	0.8
Alcohol drinker status: Never	0.5	0.6	2.1	-0.4	0.5	0.4	-0.2	-1.0	0.4	0.6	-1.4	1.0	0.8
Ever smoked	0.1	0.2	1.6	0.2	-0.2	0.0	0.4	0.1	-0.5	0.0	1.3	-0.5	-0.2
Basal metabolic rate	0.8	4.4	16.0	-1.1	-1.3	-0.9	-0.7	-0.6	2.2	4.0	-0.3	1.9	3.9
Leg fat percentage (left)	0.6	2.1	7.1	0.3	-0.7	-0.3	-0.3	0.2	2.6	2.4	-0.5	0.1	2.7
Arm fat-free mass (left)	0.9	4.4	15.0	-1.5	-1.8	-1.3	-1.1	-0.7	1.8	3.9	-0.2	1.5	3.8
Number of operations (self-reported)	1.4	2.1	4.2	-2.0	-1.0	-1.8	-1.6	-0.6	1.3	1.8	0.5	1.0	1.9
Average weekly beer plus cider intake	3.6	5.2	14.7	-2.5	-3.0	-2.1	-2.6	-3.8	0.6	-1.7	1.8	-1.3	-1.8
Irritability	1.1	1.9	7.8	1.0	0.3	1.0	1.0	0.1	1.3	0.9	2.1	-2.8	0.9
Risk taking	1.5	2.3	8.0	-1.1	-2.0	-1.9	-2.0	-2.8	0.1	-0.1	0.8	-1.0	-0.1
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.9	-0.6	-0.5	-0.6	-0.3	0.2	0.2	1.3	0.4	0.1	1.4
Fractured/broken bones in last 5 years	0.6	0.8	3.6	0.6	0.0	0.0	-0.4	-1.5	-0.8	0.1	1.9	-0.9	-0.0
Age started oral contraceptive pill	1.9	2.4	8.5	-2.1	-1.7	-2.9	-2.8	-0.3	-0.4	-0.3	0.6	-0.5	-0.3
Diastolic blood pressure, automated reading	0.1	0.3	0.9	-0.5	-0.1	-0.5	-0.6	-0.6	0.2	0.2	-1.0	-0.6	0.4
Ever depressed for a whole week	0.4	0.5	3.9	0.1	-0.2	-0.2	-0.2	-0.2	0.7	-0.1	2.0	-0.4	-0.2
Unable to work because of sickness or disability	2.1	2.8	5.5	1.5	2.1	1.2	1.3	1.4	0.0	2.3	-2.1	0.8	2.3
Commuting to job workplace: Cycle	0.4	0.5	2.2	0.8	0.6	0.6	0.8	0.2	-1.5	0.5	-0.6	-0.3	0.4
Myopia	1.7	2.5	6.2	1.1	0.8	1.9	2.5	2.2	2.5	0.7	-1.2	-0.1	0.5
Vascular/heart problems diagnosed by doctor	0.2	0.6	2.7	-0.5	-0.2	0.4	0.3	0.3	-1.6	0.0	-1.4	1.1	-0.1
Cholesterol lowering medication	0.5	0.8	1.7	0.9	1.0	0.9	1.0	0.9	1.3	0.4	-0.4	1.1	0.5
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.2	-1.1	-0.3	-1.5	-0.9	0.4	-0.2	-1.2	0.9	-1.3	-1.3
Pain experienced in last month	0.8	1.4	3.8	1.3	0.2	1.9	1.8	0.6	0.8	-1.3	-0.5	0.3	-1.4
Supplements: Calcium	1.9	2.1	5.1	1.5	1.6	1.6	2.2	2.3	-1.5	-0.7	-0.2	-0.7	-0.6
Basal cell carcinoma (self-reported)	0.7	0.8	4.4	0.3	0.4	0.5	0.1	-0.8	-0.2	-0.9	2.1	0.9	-0.9
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.2	0.7	0.1	0.4	0.3	-0.0	-0.3	0.7	-1.1	-0.4	0.6
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	5.8	-1.1	-1.6	-1.1	-1.1	-0.6	2.4	0.6	0.9	-1.1	0.6
Heart disease (siblings)	1.2	1.5	4.4	1.9	0.6	1.0	1.0	0.6	1.2	0.6	-2.1	-1.3	0.6
Alcohol drinker status: Previous	0.4	0.5	3.0	-0.6	0.1	0.3	0.1	0.1	-1.7	0.3	-0.1	-1.0	0.2
Pack years of smoking	1.1	1.6	4.6	-0.7	0.1	-0.5	-0.3	-0.2	1.5	2.1	-0.7	1.8	2.1
Impedance of whole body	0.5	2.5	5.1	2.0	2.3	2.1	1.7	0.9	-1.2	-1.6	-0.9	-0.5	-1.6
Leg fat mass (left)	0.7	2.8	9.7	0.2	-0.7	-0.0	-0.1	0.3	2.9	3.0	-0.4	0.4	3.1
Arm predicted mass (left)	0.8	4.2	15.1	-1.3	-1.6	-1.2	-1.0	-0.6	1.8	3.9	-0.2	1.6	3.8