Hub : Genes

AMFR

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1910 0.0420 1.4e-09 0.115 0.101 0.105 0.105 0.102 8.2e-14 2.8e-12 9.6e-13 9.6e-13 2.2e-12
2 GTEx Artery Coronary 0.2420 0.0920 8.7e-03 0.023 NA -0.009 NA -0.005 5.5e-02 NA 9.8e-01 NA 5.0e-01
3 GTEx Artery Tibial 0.1963 0.0528 4.0e-05 0.063 NA 0.069 NA 0.093 1.2e-05 NA 4.0e-06 NA 9.0e-08
4 GTEx Cells Transformed fibroblasts 0.1670 0.0540 8.7e-04 0.103 NA 0.062 NA 0.094 4.2e-08 NA 1.9e-05 NA 1.6e-07
5 GTEx Heart Left Ventricle 0.1795 0.0678 4.2e-03 0.075 NA 0.004 NA 0.026 8.0e-05 NA 1.8e-01 NA 1.5e-02
6 GTEx Skin Sun Exposed Lower leg 0.1620 0.0520 1.1e-04 0.005 NA 0.030 NA 0.044 1.2e-01 NA 1.6e-03 NA 1.5e-04
7 GTEx Thyroid 0.0730 0.0310 6.3e-03 -0.003 NA 0.000 NA -0.002 5.9e-01 NA 3.1e-01 NA 5.7e-01
8 YFS Blood 0.2195 0.0287 0.0e+00 0.277 0.336 0.340 0.333 0.341 3.0e-91 1.7e-114 3.0e-116 4.5e-113 1.0e-116
9 TCGA Brain Lower Grade Glioma 0.0612 0.0353 4.3e-03 0.056 0.021 0.035 NA 0.047 5.9e-07 1.8e-03 6.1e-05 NA 4.0e-06
10 TCGA Prostate Adenocarcinoma 0.0379 0.0203 1.2e-03 0.038 0.027 0.016 NA 0.029 7.5e-05 7.7e-04 7.4e-03 NA 4.5e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 0.3 0.4 1.1 0.7 -1.0 -0.0 -0.1 0.3 -0.9 0.4 -0.8 -1.0 -0.1
Bipolar Disorder or Schizophrenia 0.4 1.1 2.4 1.5 -1.0 1.0 -0.4 -0.6 0.8 0.8 -1.4 -1.2 1.1
Depressed Affect (Nagel 2018) 0.2 0.4 1.1 0.1 -0.7 -0.4 -0.5 0.2 0.1 0.9 -1.1 -0.9 -0.2
Depression (Nagel 2018) 0.2 0.3 1.3 0.4 -1.1 -0.5 0.3 0.3 -0.6 -0.3 0.2 -0.4 -0.3
Intelligence (Savage-Jansen 2018) 0.3 0.9 3.3 -0.9 -0.2 -1.3 -0.9 -0.1 -1.8 -0.3 1.5 0.6 0.1
Neuroticism (Nagel 2018) 0.3 0.7 1.7 0.7 -1.2 -0.2 -0.5 -0.5 0.8 0.9 -1.1 -1.3 0.5
Schizophrenia (2018) 0.6 1.2 2.9 1.4 -0.5 1.3 -0.4 -1.1 1.7 0.7 -1.2 -0.7 1.5
Schizophrenia vs Biploar Disorder 0.4 0.5 1.1 -0.7 0.7 -1.0 -0.1 0.7 -0.6 -0.3 1.0 0.6 -1.0
Worry (Nagel 2018) 1.1 2.3 5.5 2.3 -1.1 0.6 0.1 -0.5 2.2 1.9 -2.4 -1.2 0.7
Alzheimer’s Disease (in mother) 2.0 2.3 6.7 -0.2 -2.6 -1.6 -1.7 -1.0 1.1 1.4 -1.0 -2.2 0.9
Alzheimer’s Disease (in father) 0.6 0.7 2.1 1.1 0.5 0.6 1.1 1.4 -0.1 -0.1 0.2 -0.0 -1.2
Alzheimer’s Disease (including proxy) 1.5 2.2 5.9 0.5 -2.3 -0.9 -1.1 0.1 1.4 2.1 -1.3 -2.4 -0.1
Crohns Disease (2017) 0.2 0.5 1.3 0.4 -0.3 -0.2 -0.9 -1.1 0.5 -0.2 -0.8 -0.5 1.2
Irritable Bowel Disease (IBD) 0.6 1.4 2.9 1.0 -0.7 -0.1 -1.4 -1.2 1.6 0.6 -1.7 -1.0 1.5
Ulcerative Colitis (UC) 0.7 1.2 3.4 1.0 -0.8 0.1 -1.0 -0.5 1.8 1.1 -1.8 -1.1 0.7
Major Depression (MDD) 1.9 2.3 6.1 2.5 -0.2 0.8 -0.8 -1.4 2.3 2.0 -1.8 0.2 1.1
Reaction Time 0.7 1.3 4.8 -0.6 0.2 -0.1 0.7 0.9 -0.3 -1.6 2.2 2.0 -0.6
Verbal and Numeric Reasoning (VNR) 0.4 1.0 2.8 -1.5 -0.2 -1.6 -1.3 -0.3 -1.7 0.1 0.9 -0.2 0.1
Breast Cancer 4.7 11.3 27.5 -3.2 1.2 -0.8 3.1 3.3 -3.8 -4.9 5.2 1.6 -3.4
Ovarian Cancer 0.2 0.2 0.8 -0.7 0.5 -0.4 0.1 -0.2 0.5 0.6 0.3 0.9 -0.0
Prostate Cancer 0.3 0.4 1.2 1.1 -1.1 -0.2 0.0 -0.4 -0.8 -0.5 -0.3 -0.6 0.7
Age at First Birth 0.6 0.9 2.6 1.2 -0.8 1.1 0.7 0.3 1.1 1.1 -1.6 -0.6 -0.3
Bipolar Disorder (2011) 0.6 0.5 1.5 1.2 -0.5 0.3 -0.3 -0.9 0.4 0.3 -1.0 -0.2 1.2
Body Mass Index (BMI) (2010) 1.3 1.8 4.4 -1.5 -2.1 -1.1 -0.2 0.2 -1.5 -1.3 1.8 -1.7 -0.1
Coronary Artery Disease (CAD) 0.5 0.5 1.6 -0.2 1.3 0.9 0.9 0.1 -0.6 -1.1 0.4 0.5 -0.3
Crohns Disease (2012) 0.3 0.5 2.1 0.1 -0.2 -0.6 -0.4 -0.2 -1.1 -1.4 0.5 0.6 0.6
Mean Putamen Volume 0.6 0.7 2.5 -1.6 0.1 -0.9 -1.2 -1.0 0.2 0.0 0.5 -0.5 0.6
Fasting Glucose 0.3 0.4 1.1 -0.8 0.3 -0.3 -0.6 -0.8 1.1 0.0 -0.1 -0.4 0.6
HbA1C 0.4 0.5 1.3 0.5 1.1 0.9 0.2 0.3 1.1 0.5 -0.0 0.9 0.2
HDL Cholesterol 1.7 2.9 7.1 2.0 0.2 -0.1 -0.3 2.5 1.8 2.2 -1.8 0.6 -2.7
LDL Cholesterol 1.4 2.2 5.9 2.3 -0.4 1.0 1.1 1.0 1.0 2.4 -2.1 0.9 -0.7
Lupus 3.0 4.6 10.1 1.4 -1.5 -0.0 -1.8 -3.2 2.2 2.2 -2.6 -2.2 2.6
Neuroticism (2016) 2.0 2.9 7.0 1.6 -0.9 1.4 -0.7 -1.2 1.5 2.6 -2.6 -1.8 1.5
Primary Biliary Cirrhosis 1.2 1.7 4.8 2.2 -1.2 0.1 -0.9 -0.1 0.9 1.2 -1.8 -1.9 0.5
Rheumatoid Arthritis 0.7 0.9 4.1 0.0 2.0 1.2 0.9 0.8 -0.4 -0.3 0.4 1.0 -0.9
Schizophrenia (2014) 0.5 1.1 4.0 2.0 -0.3 1.2 -0.4 -0.3 0.9 1.0 -1.7 -0.1 0.8
Triglycerides 0.3 0.5 1.4 1.0 -0.7 0.4 0.5 -0.4 -1.2 0.0 -0.8 -0.0 0.8
Type 2 Diabetes (T2D) (2012) 5.5 6.4 16.1 -3.1 -2.7 -4.0 -2.2 0.8 -2.1 -2.1 2.4 -2.9 -1.5
Ulcerative Colitis 0.6 0.8 1.8 0.4 -1.0 -0.9 -1.4 -0.5 1.1 0.8 -1.0 -0.8 0.8
Blood Eosinophil Count 0.1 0.5 2.2 -0.1 0.3 -0.9 0.1 -0.4 -1.5 -0.8 0.9 0.8 0.2
Blood Platelet Count 0.4 5.2 10.7 1.5 3.1 2.3 3.3 3.2 -0.5 -0.0 0.0 2.5 -2.7
Blood Red Count 0.1 1.0 3.1 0.5 -1.8 -1.6 -1.1 1.0 -0.3 -0.1 -0.0 -0.9 -1.1
Blood White Count 0.3 2.3 3.9 1.9 1.5 1.2 1.9 2.0 -0.8 -0.2 -0.5 1.9 -1.9
Heel T-Score 0.5 4.2 12.0 1.4 1.3 1.9 3.5 2.4 -1.6 -2.6 1.6 1.2 -1.8
BMI 1.8 10.3 15.9 -4.0 -3.9 -3.5 -3.3 -2.8 -1.7 -3.3 3.3 -3.5 2.0
Height 0.1 2.6 5.2 0.3 1.7 0.5 2.0 2.3 -1.8 -1.3 0.1 2.2 -2.0
Waist Hip Ratio (WHR) 0.9 4.1 11.3 2.7 3.0 2.3 2.4 0.4 0.3 -0.1 -1.5 3.4 0.0
Systolic Blood Pressure 0.7 3.6 6.8 -0.8 -2.6 -0.3 -2.0 -2.4 1.7 2.1 -1.6 -2.1 2.2
Smoking Status 0.3 0.7 1.9 -0.9 0.7 -0.2 0.6 0.8 -0.2 -1.1 1.4 0.3 -1.1
Allergy or Eczema 1.2 3.2 10.2 3.2 1.3 2.4 1.8 0.6 0.4 1.8 -2.0 2.0 -0.1
Cardiovascular Disease 1.3 4.3 11.8 -1.7 -3.4 -3.0 -2.9 -1.7 -0.4 0.1 -0.4 -2.6 1.3
Hypothyroidism (self reported) 0.2 0.5 1.4 0.1 -0.2 0.8 0.6 -0.2 -1.2 1.2 -0.3 0.3 0.9
Respiratory disease 0.3 0.6 2.3 0.6 0.2 1.3 1.5 -0.2 0.7 0.3 -0.5 0.9 -0.0
Type 2 Diabetes (T2D) (2018) 0.5 1.0 3.2 -0.9 -0.3 -0.0 -0.5 -1.8 -0.9 -1.0 0.8 -1.3 1.3
Lung FEV1/FVC ratio 0.4 2.2 9.9 -0.5 1.2 1.1 1.4 1.0 -3.1 -1.5 1.1 1.6 -0.6
Lung FVC 0.3 1.4 5.2 -1.8 -1.0 -2.3 -1.4 0.9 -0.1 -0.4 0.6 -0.9 -0.7
Neuroticism 1.5 3.7 9.0 2.1 -1.3 0.4 -0.9 -1.3 2.8 2.8 -3.0 -1.3 1.2
Chronotype (morning person) 3.3 7.7 32.7 0.3 5.7 1.8 3.3 2.6 -1.1 -1.5 0.6 3.9 -2.0
Hair Pigment 0.0 1.2 2.8 -1.5 -0.8 -1.3 -0.5 -0.1 0.8 -1.4 1.0 -1.7 -0.6
Tanning 0.0 0.3 1.1 -0.8 1.1 0.0 0.2 -0.3 -0.3 0.3 0.2 0.6 0.2
Hand grip strength (left) 0.1 0.3 0.8 0.4 -0.9 -0.3 0.3 0.4 -0.1 0.7 -0.6 0.7 -0.2
Number of treatments/medications taken 0.4 0.8 2.0 0.5 -1.0 0.1 -0.5 -0.4 0.9 1.4 -1.2 -1.1 0.5
Average weekly spirits intake 2.4 2.9 11.0 2.8 0.9 3.3 2.4 0.8 0.3 0.1 -0.5 1.6 -0.2
Sensitivity / hurt feelings 1.0 1.7 7.3 0.0 -1.0 -0.1 -1.2 -1.4 2.7 0.5 -1.1 -1.2 1.5
Frequency of depressed mood in last 2 weeks 0.5 0.6 2.7 0.7 -1.6 -0.5 -0.1 -0.2 0.3 1.1 -0.9 -0.8 0.2
Hearing difficulty/problems: Yes 2.0 3.0 7.7 1.4 -1.6 1.3 -1.2 -2.2 1.1 1.9 -2.8 -1.3 1.9
Relative age of first facial hair 0.3 0.7 2.8 -1.6 0.0 -0.5 -0.3 0.5 1.7 -0.4 0.5 -0.3 -0.5
Other serious medical condition/disability diagnosed by doctor 3.5 4.5 8.7 1.8 -2.9 -0.7 -1.7 -2.0 2.4 2.5 -2.9 -1.5 1.7
Ever used hormone-replacement therapy (HRT) 0.8 1.0 4.5 1.2 1.0 2.1 1.3 0.2 0.7 0.5 -0.4 0.6 -0.1
Ever had hysterectomy (womb removed) 0.7 0.7 4.7 -0.2 0.9 0.1 -0.1 -0.1 2.2 0.9 -0.9 0.5 0.1
Systolic blood pressure, automated reading 0.4 1.2 3.6 -1.1 -1.9 -0.4 -1.4 -0.7 -0.7 -0.3 0.8 -1.8 0.6
Eye problems/disorders: Diabetes related eye disease 2.7 3.0 7.7 -0.9 -2.2 -0.2 -1.5 -2.5 0.6 0.7 -1.3 -2.4 2.8
Angina 0.8 1.0 2.9 0.4 -0.6 -0.5 -1.0 -1.7 -0.1 0.7 -1.5 -0.8 1.6
Medication for hormone replacement therapy 2.5 2.8 7.0 2.1 1.8 2.6 1.6 0.4 1.0 2.0 -2.1 1.0 0.3
Vitamin and mineral supplements 0.4 0.5 1.1 -0.1 -1.0 -1.0 -0.6 -1.1 0.2 1.0 -0.8 -0.4 0.2
Supplements: Zinc 0.5 0.5 1.2 -0.8 0.2 0.8 -0.3 -1.1 0.5 -1.0 0.6 0.4 1.0
Medication: Co-codamol 0.2 0.3 1.1 -0.8 0.0 -0.6 -0.6 -0.2 0.3 0.2 -0.1 -1.0 0.0
Medication: Metformin 1.1 1.5 4.6 -1.2 -1.1 -0.7 -0.6 -0.9 -2.2 -1.2 0.8 -1.8 0.9
Diabetes (father) 1.2 1.4 4.5 -1.6 -0.5 -1.6 -0.9 -0.2 -0.0 -2.1 1.5 -1.1 0.1
Diabetes (mother) 1.2 1.6 3.7 -0.1 1.9 0.7 1.1 1.9 -1.2 -1.1 0.6 0.5 -1.9
Severe depression (siblings) 0.4 0.5 1.9 -1.0 -0.2 -1.1 0.0 -0.1 0.1 1.4 -0.3 -0.0 -0.7
Pack years adult smoking proportion 1.8 2.7 5.8 0.4 2.1 1.6 2.2 1.8 -1.5 -0.8 1.1 2.4 -1.4
Impedance of leg (right) 1.3 6.3 13.2 3.4 2.3 1.9 2.0 1.9 1.5 3.6 -3.1 2.7 -1.6
Leg fat-free mass (left) 1.8 9.5 15.5 -3.9 -3.3 -3.7 -2.7 -1.2 -3.2 -3.8 3.4 -3.1 0.7
Trunk fat percentage 1.3 5.4 10.7 -2.5 -2.9 -3.3 -2.3 -1.1 -2.2 -2.6 2.1 -2.5 0.6
Hand grip strength (right) 0.1 0.3 0.7 -0.3 -0.6 -0.8 0.2 0.5 -0.6 0.1 0.3 0.4 -0.7
Townsend deprivation index at recruitment 2.7 3.8 8.5 -2.2 0.8 -0.8 1.2 1.8 -2.5 -2.1 2.9 1.9 -2.0
Current tobacco smoking 0.6 1.0 2.4 -0.2 0.6 -0.0 1.5 1.1 -1.3 -0.5 1.0 1.5 -1.1
Average weekly fortified wine intake 0.6 0.7 2.7 1.0 0.8 0.8 1.1 0.4 -0.8 -0.5 0.4 1.7 0.0
Maternal smoking around birth 0.9 1.3 4.5 0.6 -1.0 0.7 -0.8 -1.8 -1.1 0.2 -1.1 -0.9 2.1
Fed-up feelings 0.5 0.9 2.4 -1.2 -1.0 -1.2 -1.6 -0.6 0.3 0.9 -0.6 -0.8 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.2 0.7 0.9 -0.5 0.1 0.6 0.2 -0.5 -0.1 0.0 -0.0 -0.0
Relative age voice broke 0.5 0.7 5.5 -0.3 -0.0 0.1 -0.3 0.3 2.3 0.2 -0.1 -1.2 -0.0
Taking other prescription medications 0.8 1.2 5.2 0.4 -0.2 -0.2 -0.5 -1.2 0.3 1.9 -2.3 -0.1 1.1
Age when periods started (menarche) 0.9 2.2 5.2 0.4 -0.5 -1.2 -1.9 0.0 1.8 2.3 -2.0 -1.9 -0.0
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.8 -1.3 -0.9 -0.9 -0.4 0.8 -0.3 -0.5 0.6 -1.1 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.8 7.4 0.3 1.5 1.4 1.9 1.7 -2.7 -2.0 1.6 1.1 -1.4
Tinnitus: Yes, but not now, but have in the past 2.9 3.1 5.9 0.9 2.3 1.5 2.2 2.3 1.2 -0.1 0.5 2.4 -2.3
Qualifications: CSEs or equivalent 1.5 2.0 4.1 -0.0 -0.4 -0.8 -2.0 -1.8 2.0 1.6 -1.8 -0.7 1.2
Serious illness, injury or assault to yourself 0.6 0.7 2.7 1.6 -0.1 0.3 0.1 -0.5 -0.5 0.5 -1.6 -0.7 0.3
High blood pressure 0.5 1.4 3.4 -1.3 -1.9 -1.3 -1.1 -0.6 -0.7 -1.6 1.2 -0.9 0.6
Hayfever, allergic rhinitis or eczema 1.2 2.6 8.1 2.8 0.4 2.4 1.5 -0.4 1.1 1.6 -1.9 1.3 0.7
Multivitamins +/- minerals 0.6 0.7 1.8 -0.1 1.1 1.4 0.9 1.0 -0.5 -1.1 0.8 0.7 -0.1
Stomach or abdominal pain in last month 2.2 2.7 7.3 1.7 2.6 2.7 1.9 0.5 0.7 0.7 -0.0 2.4 -0.2
Supplements: Glucosamine 0.6 0.8 3.3 -1.8 -0.9 -0.3 -1.0 -0.7 -0.4 -0.4 0.7 -0.9 0.7
Diverticular disease/diverticulitis (self-reported) 2.1 2.4 6.7 1.6 1.6 2.6 1.1 0.7 1.8 1.9 -1.3 1.6 -0.1
Medication: Atenolol 0.5 0.7 1.9 -0.4 -1.4 -0.4 -0.6 -0.8 -0.8 -1.1 0.5 -0.8 0.8
Medication: Levothyroxine sodium 0.3 0.5 1.4 0.6 -0.8 0.2 -0.0 -0.5 -0.7 1.2 -1.1 -0.2 0.7
Sitting height 0.2 1.2 4.6 -1.0 -0.5 -1.6 -0.4 0.8 -2.1 -1.2 0.9 0.4 -0.7
Chronic bronchitis/emphysema (father) 0.5 0.6 2.1 -0.1 -0.6 -0.4 -1.0 -1.4 0.6 -0.3 -0.3 -0.7 1.3
High blood pressure (mother) 0.3 0.4 1.8 0.2 0.4 1.3 1.0 -0.1 -0.2 -0.4 -0.0 0.5 0.3
Body mass index (BMI) 2.5 10.7 16.7 -4.1 -3.8 -3.6 -3.2 -2.0 -2.3 -3.9 3.5 -3.7 1.5
Impedance of leg (left) 1.7 8.2 17.4 4.2 3.0 2.5 2.7 2.1 1.4 3.5 -3.0 3.6 -1.6
Leg predicted mass (left) 1.8 9.5 16.0 -4.0 -3.2 -3.6 -2.5 -1.1 -3.3 -4.0 3.5 -2.9 0.6
Trunk fat mass 1.8 7.9 13.7 -3.2 -3.2 -3.7 -2.6 -1.1 -2.8 -3.4 2.9 -2.8 0.6
Waist circumference 1.4 5.2 12.2 -2.3 -2.5 -3.0 -1.9 -0.9 -2.1 -3.5 2.6 -2.0 0.5
Number of incorrect matches in round 0.5 0.8 4.3 0.3 0.4 0.9 0.5 -0.3 2.1 0.6 -0.6 1.3 0.2
Past tobacco smoking 0.2 0.4 1.1 -0.0 0.9 -0.6 0.2 0.4 0.1 1.0 -0.8 0.8 -0.5
Alcohol usually taken with meals 0.3 0.4 1.1 0.5 1.1 0.8 1.0 -0.5 -0.1 0.3 0.7 0.6 0.5
Nervous feelings 2.8 5.3 14.2 1.3 -2.1 -0.1 -1.6 -2.1 3.8 2.8 -3.3 -1.3 2.2
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.2 1.1 -0.5 0.8 0.4 -0.4 -0.5 0.9 -0.7 -0.2 0.9
Hearing difficulty/problems with background noise 1.5 2.3 6.8 2.6 -0.4 2.4 1.1 -0.4 0.4 1.8 -2.3 -0.1 0.7
Hair/balding pattern: Pattern 2 0.5 0.6 1.7 0.3 0.2 1.3 1.2 1.0 0.5 0.2 0.4 -0.6 -1.0
Had menopause 0.4 0.5 1.3 -0.9 0.3 0.2 0.6 0.9 -0.1 -0.6 1.0 -0.2 -1.1
Had other major operations 1.3 1.6 6.6 1.7 0.3 0.2 0.2 0.3 1.0 2.6 -1.9 0.9 -0.6
Forced vital capacity (FVC) 0.1 0.5 1.4 0.6 -0.6 -0.8 -0.8 0.3 -0.3 1.2 -1.1 -0.2 0.3
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.7 5.3 0.7 1.0 1.2 1.7 1.5 -2.3 -1.3 0.8 0.7 -1.3
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.5 0.7 -0.8 -1.2 -0.6 0.5 0.7 0.4 -0.5 -0.1 -1.1
Qualifications: None of the above 0.3 0.7 2.8 -1.7 -0.8 -0.9 -0.8 -0.6 -0.5 -0.7 0.5 -0.5 0.3
Financial difficulties in last 2 years 1.1 1.4 3.0 0.2 1.2 0.0 1.6 1.7 -0.6 -1.4 1.0 1.1 -1.7
Mouth/teeth dental problems 0.5 0.8 3.2 1.8 0.8 0.3 0.5 0.9 0.4 0.3 -0.3 1.1 -1.1
Heart attack 0.6 0.7 2.8 -0.3 -0.4 -0.6 -1.2 -1.7 -0.4 -0.1 -0.1 -0.8 1.3
Allergy 1.1 2.4 6.8 -2.5 1.0 -1.7 -0.8 0.9 -0.9 -2.0 2.6 0.1 -1.0
Pain all over the body in last month 2.1 2.3 6.4 0.1 -2.5 -1.2 -1.7 -1.4 -1.0 1.9 -1.5 -1.2 1.4
Diabetes (self-reported) 1.4 2.1 7.0 -0.5 -1.6 -0.5 -1.7 -2.1 -0.0 -0.3 -0.4 -2.6 1.9
Hayfever/allergic rhinitis (self-reported) 2.5 3.4 9.1 2.6 0.7 2.1 1.5 -0.3 2.0 3.0 -2.4 0.7 0.8
Medication: Ramipril 0.3 0.3 1.4 0.3 1.2 0.5 0.2 -0.7 0.1 -0.2 -0.4 0.7 0.8
Medication: Simvastatin 0.4 0.6 2.3 -0.9 -0.2 0.4 0.3 -1.1 -1.5 -1.0 0.3 0.1 0.9
Fluid intelligence score 0.8 1.7 5.9 -1.4 -0.6 -2.4 -1.4 0.1 -2.0 -0.1 1.6 -0.1 -0.5
Illnesses of siblings 1.5 2.1 3.0 0.8 -1.7 -1.1 -1.7 -1.6 1.3 1.6 -1.5 -1.4 1.5
Neuroticism score 2.4 5.0 12.0 1.8 -2.0 0.4 -1.6 -1.8 3.5 2.9 -3.2 -1.7 1.9
Weight 2.2 11.0 18.5 -4.3 -3.6 -4.2 -3.0 -1.1 -3.2 -4.1 3.6 -3.2 0.6
Impedance of arm (right) 0.6 3.0 9.3 2.2 1.3 0.6 0.7 1.2 1.1 3.0 -3.0 1.2 -0.9
Arm fat percentage (right) 2.0 8.0 13.1 -2.9 -3.6 -3.5 -3.2 -2.0 -2.0 -2.8 2.3 -3.6 1.5
Trunk fat-free mass 1.1 6.3 12.1 -3.5 -2.3 -3.0 -1.7 -0.3 -3.0 -3.2 3.3 -1.8 -0.0
Hip circumference 2.4 10.5 18.7 -3.7 -4.3 -4.3 -3.6 -1.9 -2.3 -3.1 2.9 -3.6 1.3
Time employed in main current job 0.7 0.8 1.8 1.4 1.2 1.1 0.7 0.2 -1.2 -0.3 -0.7 0.8 0.0
Alcohol intake versus 10 years previously 1.1 1.6 4.1 -0.6 0.9 -0.3 1.0 2.0 0.4 -1.5 1.7 0.8 -2.0
Father’s age at death 0.8 1.1 3.8 -0.7 1.0 0.6 0.9 1.9 -0.4 -0.4 0.6 -0.2 -1.9
Worrier / anxious feelings 1.7 3.2 7.7 2.3 -1.8 0.2 -0.7 -1.3 1.8 2.5 -2.8 -1.8 1.1
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 1.6 1.3 -0.7 -0.0 0.5 1.0 -0.1 0.7 -0.3 0.7 -0.8
Falls in the last year 0.2 0.3 1.1 0.7 1.0 0.3 -0.2 0.1 0.1 0.1 -0.9 -0.1 -0.1
Hair/balding pattern: Pattern 3 0.8 1.1 4.6 2.1 0.5 1.8 0.9 -0.7 0.1 0.5 -0.6 0.8 0.8
Number of live births 1.3 1.8 8.1 -0.7 -2.0 0.3 -1.2 -0.7 0.2 1.5 -0.6 -2.8 0.9
Forced expiratory volume in 1-second (FEV1) 0.1 0.4 1.1 0.1 -0.7 -0.5 -1.1 -0.0 -0.7 0.8 -0.7 -0.3 0.7
Pulse rate 1.6 2.8 6.8 -1.9 -1.9 -2.6 -2.2 0.2 -0.4 -1.0 1.7 -2.0 -0.6
Happiness 2.9 3.5 10.6 3.3 -1.3 2.0 0.3 -1.3 1.7 2.5 -2.1 -0.1 1.8
Noisy workplace 0.6 0.7 3.1 -1.8 0.5 -0.5 -0.3 -0.5 -0.9 -1.3 0.7 -0.0 0.2
Qualifications: A levels/AS levels or equivalent 1.0 2.2 5.9 1.4 -0.7 0.1 -1.1 -1.1 2.4 2.1 -2.2 -0.8 1.0
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 4.4 0.2 0.2 -0.5 0.6 -0.2 -2.1 -1.3 1.0 0.7 -0.1
Mouth/teeth dental problems: Dentures 1.6 2.6 6.9 -2.5 -2.1 -1.6 -1.6 -1.4 -0.6 -0.2 -0.1 -2.6 1.4
Asthma 0.4 0.8 2.4 0.4 -0.8 0.7 0.4 -0.8 1.5 1.2 -1.2 -0.5 0.6
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.7 2.3 1.2 1.5 0.6 0.7 0.2 0.6 0.3 0.2 1.5 0.1
Medication: Cholesterol lowering 1.2 1.8 3.8 -0.7 -1.9 -1.6 -1.9 -1.4 -0.3 -0.3 -0.9 -1.8 1.1
Depression (self-reported) 3.7 4.4 9.8 1.1 -3.1 -1.5 -2.3 -1.1 1.9 2.4 -2.9 -2.3 1.1
Medication: Lansoprazole 0.5 0.6 2.0 0.7 -0.7 -0.3 -0.4 -0.0 0.9 1.4 -1.4 -0.0 -0.2
Prospective memory result 2.9 3.6 7.5 1.2 2.7 2.7 2.6 1.5 -1.2 -1.4 1.2 2.4 -0.8
Lung cancer (father) 0.5 0.6 2.2 -0.0 1.5 1.3 0.6 -0.3 0.2 -0.2 -0.7 0.8 0.8
Illnesses of mother 0.4 0.5 2.2 -0.4 1.1 0.3 0.3 -0.1 1.5 0.5 0.0 0.8 -0.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 1.9 -1.0 -0.2 -0.9 -0.5 1.4 -1.1 0.0 0.2 0.4 -0.7
Pulse wave Arterial Stiffness index 1.5 1.8 5.0 -2.2 -0.6 -2.2 -0.7 0.4 -1.1 -1.5 1.5 -0.6 -0.9
Impedance of arm (left) 0.7 3.1 6.7 2.0 1.9 0.7 1.2 1.3 0.9 2.5 -2.6 2.0 -1.2
Arm fat mass (right) 2.4 9.7 15.3 -3.7 -3.7 -3.9 -3.1 -1.7 -2.6 -3.6 3.1 -3.4 1.1
Trunk predicted mass 1.1 6.2 12.0 -3.5 -2.3 -2.9 -1.6 -0.3 -3.0 -3.1 3.3 -1.8 -0.0
Standing height 0.2 1.7 4.5 -1.0 -0.2 -1.8 0.1 1.8 -2.1 -0.8 0.6 0.7 -1.8
Length of working week for main job 1.2 1.4 3.6 1.4 1.9 0.9 1.2 1.0 0.8 0.2 -0.5 1.8 -0.9
Exposure to tobacco smoke at home 0.2 0.2 0.9 -0.5 0.8 -0.3 0.2 0.1 -0.2 -0.2 0.9 0.4 -0.4
Breastfed as a baby 1.1 1.3 5.9 -0.8 -1.3 -2.4 -1.0 1.0 -0.0 0.8 0.3 -0.6 -1.3
Tense / ‘highly strung’ 3.2 5.4 12.0 3.1 -0.3 2.0 -0.1 -1.4 3.2 3.4 -3.5 0.2 2.0
Seen doctor (GP) for nerves, anxiety, tension or depression 2.6 4.0 13.8 3.4 -0.9 0.9 -0.2 -0.4 0.8 3.7 -3.5 0.2 0.5
Hair/balding pattern: Pattern 4 1.1 2.6 6.8 -0.8 -2.1 -2.6 -2.5 -1.7 -0.0 0.4 -0.8 -1.4 1.4
Birth weight of first child 1.3 2.3 5.0 -1.7 0.3 -1.4 0.7 1.6 -1.2 -2.1 2.2 0.8 -1.8
Peak expiratory flow (PEF) 0.3 0.8 1.9 0.5 -0.9 -0.1 -1.2 -0.8 -0.7 -0.2 -0.2 -1.4 1.4
Pulse wave reflection index 0.4 0.5 2.1 -0.4 1.5 0.2 0.6 0.8 -0.5 -0.5 0.1 1.1 -0.7
Ever highly irritable/argumentative for 2 days 0.5 0.5 1.2 0.9 -0.6 0.2 -0.3 -1.1 0.8 0.6 -1.1 -0.4 0.8
Loud music exposure frequency 0.4 0.4 1.0 1.0 0.5 0.1 0.3 0.8 -0.8 -0.7 -0.4 0.7 -0.6
Qualifications: O levels/GCSEs or equivalent 2.3 3.7 7.5 1.6 -2.1 0.0 -1.6 -2.0 2.0 1.7 -2.7 -2.2 2.0
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 1.5 -1.2 0.6 0.1 0.1 0.1 -0.0 -0.4 0.4 0.7 -0.1
Blood clot in the leg (DVT) 0.3 0.3 1.4 1.2 0.1 0.1 0.1 -0.6 -0.7 0.2 -0.6 -0.7 0.6
Medication: Paracetamol 1.5 2.5 6.7 2.6 0.8 2.5 1.2 -0.2 2.2 1.5 -1.4 0.9 0.6
Headache pain in last month 1.3 2.2 6.4 2.5 0.7 1.9 1.7 1.2 1.0 1.3 -1.9 0.8 -0.6
Medication for cholesterol, blood pressure or diabetes 0.7 1.1 2.1 1.2 1.2 1.4 1.3 0.9 1.0 1.1 -0.2 0.9 -0.7
Glaucoma (self-reported) 1.1 1.3 5.7 1.6 0.5 2.4 0.6 -0.5 0.7 1.3 -1.0 -0.5 1.0
Gout (self-reported) 0.8 1.1 2.0 0.2 -1.3 -0.9 -1.2 -0.7 -1.1 0.9 -1.2 -1.4 0.7
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 1.3 0.4 -0.1 0.6 0.7 0.4 -0.7 1.1 -0.7 -0.0 0.1
Medication: Amlodipine 0.7 1.0 3.2 -0.8 -0.7 -1.5 -1.8 -1.4 0.3 0.5 0.2 -0.6 1.1
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.0 0.3 -1.0 -0.7 -0.5 -0.4 0.9 0.6 -0.5 -0.9 0.2
Birth weight 0.7 1.6 5.3 -1.4 -1.2 -2.3 -1.5 0.4 -0.9 -0.9 1.3 -1.0 -0.7
Chronic bronchitis/emphysema (mother) 0.7 0.8 2.8 1.0 0.0 0.7 -0.6 -1.4 -0.1 0.3 -0.8 -0.7 1.7
High blood pressure (siblings) 0.8 1.2 2.2 -0.2 1.1 0.8 1.5 1.4 -0.2 -1.1 1.3 1.2 -1.3
Forced vital capacity (FVC), Best measure 0.1 0.5 1.4 -0.5 -0.6 -1.2 -0.8 0.9 -0.8 0.6 -0.2 0.1 -0.3
Body fat percentage 1.5 6.0 9.7 -2.6 -3.1 -3.1 -2.5 -1.4 -2.0 -2.7 2.3 -2.8 0.9
Leg fat percentage (right) 2.0 7.2 11.0 -3.1 -3.3 -3.1 -2.5 -1.1 -2.3 -3.0 3.1 -3.2 0.7
Arm fat-free mass (right) 1.0 5.4 11.6 -3.0 -2.0 -2.5 -1.2 -0.3 -2.8 -3.4 3.4 -1.3 -0.1
Exposure to tobacco smoke outside home 1.4 1.9 7.7 -0.6 0.2 -0.7 0.7 0.1 -1.9 -2.4 2.8 -0.2 -0.4
Comparative body size at age 10 1.0 2.9 7.9 -2.1 -2.8 -2.5 -1.8 -1.0 0.3 -0.8 1.2 -1.9 0.7
Number of full brothers 0.6 0.7 2.7 -0.4 -0.8 -0.2 -0.7 -0.7 1.6 0.7 -0.8 -1.0 0.7
Worry too long after embarrassment 2.9 4.9 8.8 -0.6 -2.7 -0.8 -2.4 -2.7 3.0 2.0 -1.7 -2.4 2.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 2.6 1.3 0.0 0.4 0.1 -0.2 -0.7 1.6 -0.9 0.8 0.4
Wheeze or whistling in the chest in last year 0.8 1.5 3.1 1.4 -1.6 0.6 -0.4 -0.7 1.5 1.6 -1.7 -1.0 0.6
Number of children fathered 0.6 0.7 1.6 1.0 1.3 -0.1 -0.1 1.2 -0.9 -0.3 -0.3 0.4 -1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 2.2 -0.8 -0.2 -0.3 -0.7 -0.2 1.5 -0.2 -0.3 -0.8 0.3
Age at first live birth 0.6 1.0 2.8 0.2 -1.7 -1.7 -1.5 -0.3 0.8 -0.1 -0.3 -1.1 0.1
Pulse wave peak to peak time 1.3 1.5 4.7 2.2 0.6 2.0 0.6 -0.3 0.7 1.5 -1.4 0.7 0.8
Health satisfaction 0.7 0.9 2.8 1.6 -0.1 1.1 -0.3 -1.4 0.5 -0.1 -0.1 -0.1 1.7
Shortness of breath walking on level ground 0.7 0.8 3.3 0.3 -0.5 -0.8 -1.8 -0.4 -0.4 0.9 -1.6 -0.5 0.5
Qualifications: College or University degree 0.1 0.2 1.2 1.1 0.1 0.4 0.3 0.4 0.6 0.5 -0.4 0.0 -0.4
Eye problems/disorders: None of the above 0.4 0.5 1.8 -1.3 -0.5 -0.9 -0.6 0.2 0.8 -0.3 0.4 0.3 -0.6
Mouth/teeth dental problems: Loose teeth 2.7 3.2 8.1 -2.8 -1.4 -1.7 -1.3 -1.1 -1.7 -1.5 1.9 -2.7 0.7
Emphysema/chronic bronchitis 0.4 0.4 2.0 0.4 -0.4 -0.0 -0.2 -0.6 1.4 0.6 -0.9 0.2 0.5
Medication for pain relief, constipation, heartburn 1.6 2.8 6.9 -2.4 -2.1 -2.6 -1.5 0.5 -0.7 -1.1 1.0 -2.2 -0.8
Neck or shoulder pain in last month 2.0 2.8 9.4 1.2 3.1 2.5 1.8 -0.0 1.4 0.8 -0.6 2.2 0.0
Medication: Blood pressure 0.2 0.4 2.4 -0.0 -1.6 -0.8 -0.7 0.0 -0.3 -0.3 -0.2 -0.6 0.2
Angina (self-reported) 0.6 0.8 2.0 0.2 -0.7 -0.8 -1.0 -1.4 -0.3 0.5 -1.3 -0.8 1.3
Migraine (self-reported) 0.5 0.7 1.6 -0.2 -0.9 -1.3 -1.0 -1.1 -0.2 0.4 -0.0 -1.1 0.9
Medication: Ibuprofen 0.6 0.7 2.2 1.1 1.5 -0.0 0.6 0.6 0.3 -0.5 0.7 1.4 -0.4
Medication: Allopurinol 0.4 0.6 1.4 -1.2 -1.0 -0.9 -0.6 -0.2 -0.8 -0.4 -0.3 -1.2 -0.2
Medication: Omeprazole 2.6 3.1 6.3 2.4 2.5 1.9 1.8 0.6 1.2 1.7 -1.4 2.2 -0.8
Medication: Seretide 50 evohaler 0.6 0.7 1.9 -0.6 1.0 0.5 1.4 1.1 -0.7 -0.5 0.6 0.3 -1.2
Mean time to correctly identify matches 0.9 1.7 5.8 -0.9 0.6 0.6 1.1 0.9 -0.5 -2.1 2.4 1.5 -0.7
Heart disease (mother) 0.3 0.4 1.3 0.8 -0.4 0.1 0.6 0.7 -1.2 -0.5 0.2 0.4 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 0.9 0.6 -1.0 0.3 -0.0 0.6 0.1 0.4 -0.8 -0.3 -0.3
Whole body fat mass 2.1 8.6 13.7 -3.3 -3.4 -3.4 -2.6 -1.4 -3.0 -3.7 3.2 -3.0 0.9
Leg fat mass (right) 2.8 10.8 16.4 -3.8 -3.8 -3.9 -3.0 -1.4 -3.2 -4.0 3.8 -3.5 0.8
Arm predicted mass (right) 1.1 5.4 11.2 -3.0 -2.0 -2.6 -1.6 -0.5 -2.7 -3.2 3.4 -1.4 0.2
Pulse rate, automated reading 2.4 7.7 20.1 -2.5 -3.8 -4.2 -4.5 -1.0 -0.1 -0.6 1.6 -3.8 0.4
Alcohol intake frequency. 0.2 0.4 1.4 -1.2 0.3 0.2 0.1 0.7 -0.4 -1.0 0.6 0.5 -0.2
Comparative height size at age 10 1.1 6.0 11.6 -0.8 2.1 0.4 2.8 3.2 -3.2 -2.0 1.8 3.4 -2.8
Number of full sisters 1.0 1.3 3.4 -0.6 -1.1 -0.8 -1.5 -1.7 1.2 0.2 -0.2 -0.6 1.8
Suffer from ‘nerves’ 0.8 1.3 3.1 0.2 -0.8 0.2 -0.8 -1.8 1.3 1.2 -1.0 -1.1 1.7
Overall health rating 0.2 0.5 1.9 1.0 -1.4 0.3 -0.2 -0.8 -0.0 0.5 -0.6 -0.5 0.8
Chest pain or discomfort 0.4 0.6 1.9 1.4 -0.2 -1.0 -0.5 0.3 -0.3 1.1 -0.9 0.5 -0.6
Had major operations 0.8 0.9 4.4 2.1 0.9 0.4 0.4 -0.3 -0.9 1.0 -1.0 0.6 -0.1
Age at last live birth 1.0 1.4 8.8 0.4 -3.0 -1.0 -0.5 -0.4 -0.3 -0.5 -0.1 -1.8 0.4
Family relationship satisfaction 0.7 0.9 2.5 1.0 0.5 1.3 1.6 0.9 0.8 -0.3 0.5 1.2 -0.3
Leg pain on walking 0.8 1.0 5.0 2.2 0.2 1.5 1.4 0.0 -0.1 0.9 -0.7 -0.0 0.2
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 3.9 -1.7 0.1 -2.0 -1.2 0.2 -1.4 -0.8 0.9 -0.2 -0.6
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.4 -0.2 0.7 -0.3 0.3 0.0 -0.0 -0.4 -0.1 -0.3 -0.3
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 6.1 0.3 0.2 1.9 -0.3 -0.1 2.5 2.2 -0.9 0.5 0.8
Medication: Aspirin 0.6 0.8 4.0 0.3 0.7 0.6 0.6 -0.1 -2.0 0.2 -0.3 1.5 -0.0
Supplements: Vitamin C 0.3 0.4 1.2 -0.9 -0.0 -0.4 -0.0 0.2 0.3 -0.7 1.1 -0.9 -0.3
Knee pain experienced in last month 0.1 0.2 0.6 0.2 -0.3 -0.5 -0.2 -0.1 0.7 0.7 -0.3 -0.6 -0.2
Hypertension (Self-reported) 0.4 1.1 3.0 -1.1 -1.7 -1.1 -0.9 -0.5 -0.5 -1.5 1.1 -0.7 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 1.2 -0.1 0.5 -0.4 -0.9 -0.7 -0.0 1.1 -0.6 0.4 0.3
Illnesses of father: Heart disease 0.3 0.4 1.4 0.9 -1.2 -0.4 -0.4 -0.4 -0.9 0.2 -0.2 -0.3 0.4
Illnesses of siblings: Diabetes 0.2 0.3 0.9 -0.9 -0.1 -0.1 -0.5 -0.1 -0.3 -0.8 0.0 -1.0 0.3
Smoking status: Previous 0.4 0.7 2.1 -0.0 -0.5 0.8 -0.8 -1.3 0.5 -0.1 -0.1 -1.1 1.4
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.8 6.2 -0.5 2.2 -1.1 0.4 1.7 -0.6 0.5 0.2 2.5 -1.5
Whole body fat-free mass 1.3 7.5 13.2 -3.6 -2.7 -3.2 -2.0 -0.7 -3.2 -3.5 3.5 -2.2 0.3
Leg fat-free mass (right) 1.6 8.3 14.7 -3.7 -2.9 -3.3 -2.4 -1.2 -3.1 -3.8 3.4 -2.6 0.8
Arm fat percentage (left) 1.8 7.2 10.3 -3.0 -3.1 -3.2 -2.7 -1.8 -2.2 -3.1 2.7 -3.0 1.3
Average weekly red wine intake 0.5 0.8 4.0 2.0 0.7 0.8 0.9 0.7 -0.6 0.4 -0.4 1.0 -0.2
Handedness (chirality/laterality): Left-handed 0.8 1.0 5.0 0.8 -2.2 0.5 -0.6 -0.2 -0.2 0.2 -0.4 -1.4 1.2
Mood swings 1.1 1.9 6.8 0.9 -0.9 -0.2 -1.0 -0.3 1.9 2.6 -2.1 -1.0 0.4
Loneliness, isolation 0.3 0.4 1.0 1.0 -0.8 0.7 0.5 0.2 1.0 0.5 -0.5 -0.4 0.4
Long-standing illness, disability or infirmity 0.3 0.4 1.7 -0.5 -1.3 -0.4 -0.3 -0.3 0.3 0.1 -0.6 -1.1 -0.3
Ever had bowel cancer screening 0.2 0.2 0.6 -0.5 0.8 0.8 0.4 -0.2 -0.4 0.6 -0.1 -0.1 -0.1
Diabetes diagnosed by doctor 0.9 1.5 4.4 -0.2 -0.9 -0.0 -1.0 -2.1 -0.5 -0.6 -0.2 -2.1 1.9
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 3.6 -1.2 0.3 -0.9 0.4 1.5 -0.2 0.7 -0.2 1.1 -1.9
Friendships satisfaction 0.4 0.5 1.8 0.5 -0.7 1.3 -0.2 -0.7 0.0 -0.2 0.2 -0.0 1.3
Qualifications: nursing, teaching 0.4 0.6 1.9 0.9 -0.6 -0.5 -0.4 0.4 0.0 1.4 -1.3 -0.7 -0.6
Commuting to job workplace: Walk 0.2 0.3 0.8 0.5 -0.9 -0.0 0.1 0.8 0.5 0.3 0.0 0.1 -0.6
Eye problems/disorders: Cataract 1.1 1.3 2.9 1.7 -0.4 0.6 -0.4 -1.0 0.7 1.6 -1.6 -1.1 1.2
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.5 0.2 0.0 0.6 0.7 0.3 0.3 -0.2 -0.1 -0.1 -0.0
Medication for cholesterol 0.2 0.3 1.0 -0.0 -0.4 -0.1 0.0 0.5 -1.0 -0.9 0.8 0.1 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 1.2 0.0 -1.1 0.3 -0.9 -0.7 0.4 -0.1 -0.7 -0.8 0.9
Back pain experienced in last month 0.6 0.9 2.8 1.2 1.1 1.7 1.2 0.5 0.6 0.4 -0.4 1.0 -0.0
Mineral and other dietary supplements 0.2 0.3 1.0 0.8 -0.4 -0.1 0.2 -0.1 0.3 0.7 -1.0 0.1 -0.2
Breast cancer (self-reported) 0.3 0.3 0.8 0.7 0.7 -0.4 0.1 0.6 -0.4 0.4 -0.4 0.8 -0.9
Asthma (self-reported) 0.3 0.6 2.0 0.2 -0.8 0.6 0.4 -0.7 1.4 0.9 -1.0 -0.4 0.5
Osteoporosis (self-reported) 0.6 0.8 2.9 -1.7 -0.9 -1.0 0.1 0.2 0.5 -0.7 0.8 -1.1 -0.6
Osteoarthritis (self-reported) 1.1 1.4 4.5 0.3 -2.1 -0.4 -1.2 -1.6 0.8 1.0 -0.8 -1.3 1.0
Medication: Aspirin 0.6 0.7 5.1 0.3 0.8 0.2 0.3 -0.0 -2.3 0.0 -0.1 1.2 -0.1
Medication: Gliclazide 0.7 0.8 4.2 2.0 -0.4 0.4 -0.2 -0.7 0.5 1.2 -0.6 -0.4 0.9
Illnesses of father: None of the above (group 1) 0.7 0.9 2.5 -0.5 1.6 0.8 0.9 1.4 0.2 0.3 -0.2 1.0 -1.3
Smoking status: Current 1.0 1.6 3.1 -0.2 0.7 -0.1 1.7 1.7 -1.2 -0.9 1.3 1.5 -1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 2.9 0.3 0.1 0.7 1.4 1.7 -1.2 -0.9 0.8 0.8 -1.0
Whole body water mass 1.3 7.1 12.5 -3.5 -2.7 -3.0 -1.9 -0.7 -3.1 -3.5 3.4 -2.2 0.4
Leg predicted mass (right) 1.6 8.3 14.5 -3.6 -2.9 -3.3 -2.4 -1.3 -3.1 -3.8 3.4 -2.6 0.9
Arm fat mass (left) 2.3 9.5 13.9 -3.7 -3.6 -3.7 -3.1 -1.8 -2.6 -3.7 3.1 -3.3 1.3
Number of self-reported non-cancer illnesses 1.6 2.8 6.1 0.3 -2.0 -0.3 -1.1 -2.5 0.7 2.4 -2.1 -1.5 1.9
Average weekly champagne plus white wine intake 0.7 0.9 3.5 -0.6 0.1 0.0 -1.3 -1.9 -0.6 1.0 -0.5 -0.2 1.4
Miserableness 0.9 1.5 3.8 0.7 -1.4 -0.1 -1.2 -0.8 0.8 2.0 -1.7 -1.6 0.7
Guilty feelings 0.6 0.9 4.4 -0.1 -2.1 -0.7 -0.5 -0.2 -0.4 -1.3 1.0 -1.1 0.2
Wears glasses or contact lenses 0.3 0.3 1.5 1.2 0.4 0.9 0.2 -0.3 -0.1 0.7 -0.4 0.5 -0.1
Ever taken oral contraceptive pill 0.5 0.5 1.6 0.8 0.6 1.2 0.8 -0.4 -0.5 0.4 -0.5 0.8 0.7
Hearing aid user 1.1 1.3 4.4 0.4 -0.4 0.0 -1.4 -1.0 1.4 1.6 -2.1 -0.1 0.8
Mother’s age at death 0.2 0.3 1.6 1.3 0.4 0.2 -0.2 -0.3 -0.3 0.3 -0.8 -0.5 0.2
Financial situation satisfaction 2.5 3.1 7.8 2.8 2.4 1.8 2.4 1.0 0.6 0.3 -0.4 2.6 -0.5
Tinnitus: Yes, now most or all of the time 1.5 1.8 4.8 2.0 1.6 2.2 1.3 -0.0 0.5 1.2 -1.5 1.0 0.0
Commuting to job workplace: Public transport 0.7 0.9 5.3 -0.6 -0.3 -0.1 0.0 0.5 -2.3 -0.9 1.0 0.8 -0.2
Eye problems/disorders: Glaucoma 0.3 0.4 2.3 0.5 0.4 1.5 0.4 -0.1 -0.4 0.3 0.1 -0.5 0.6
Medication: Blood pressure 0.4 0.7 1.9 -1.3 -0.1 -1.1 -0.4 -0.3 0.1 -1.4 1.3 -0.4 -0.0
Pain type(s) experienced in last month: Hip pain 0.7 0.9 2.9 0.7 -1.0 0.1 -0.6 -1.7 1.0 1.2 -0.7 -0.8 1.1
Supplements: Fish oil (including cod liver oil) 0.7 0.9 2.2 -1.3 -0.6 -1.0 -1.4 -0.3 -0.5 -1.0 0.8 -1.5 0.5
High cholesterol (Self-reported) 0.5 0.8 2.2 -0.6 -1.1 -0.1 -0.5 -1.5 -0.8 0.0 -0.2 -1.1 1.4
Medication: Bendroflumethiazide 0.5 0.8 3.0 -1.7 -0.7 -1.1 -0.8 -0.8 0.6 -0.8 0.9 -0.5 0.5
Medication: Paracetamol 0.5 0.8 2.9 1.7 0.3 1.4 0.8 0.1 1.3 0.6 -0.6 0.6 0.3
Medication: Lisinopril 0.2 0.3 1.9 -0.2 0.3 1.4 0.7 -0.0 0.2 0.1 0.2 0.2 0.1
Medication: Atorvastatin 1.2 1.5 3.0 0.7 -1.1 -1.3 -1.3 -1.6 1.0 1.7 -1.3 -0.9 1.1
Illnesses of father: High blood pressure 0.4 0.5 2.1 0.7 -0.2 1.4 1.2 -0.2 0.1 0.8 -0.3 0.3 0.7
Alcohol drinker status: Never 0.7 0.9 3.4 -1.9 -0.2 -0.6 0.0 1.0 -1.3 -1.1 0.7 -0.1 -0.8
Ever smoked 0.5 0.9 3.4 -0.3 -1.1 0.4 0.6 0.5 -0.3 -1.9 1.7 -0.7 -0.4
Basal metabolic rate 1.6 8.8 14.8 -3.9 -3.1 -3.5 -2.4 -0.9 -3.2 -3.7 3.5 -2.7 0.5
Leg fat percentage (left) 1.6 5.9 10.2 -2.5 -2.9 -2.5 -2.1 -1.1 -2.2 -3.1 3.2 -2.7 0.7
Arm fat-free mass (left) 1.6 7.9 12.5 -3.5 -3.3 -3.4 -2.4 -0.8 -3.0 -3.3 3.2 -2.7 0.4
Number of operations (self-reported) 2.6 3.9 15.2 2.5 -0.4 -0.4 -0.9 -0.5 2.0 3.9 -3.5 -0.3 -0.2
Average weekly beer plus cider intake 1.7 2.4 6.8 -1.4 1.4 0.8 1.2 0.8 -1.8 -2.6 2.3 1.2 -0.8
Irritability 0.8 1.3 4.2 2.0 1.0 1.5 1.1 0.9 -0.7 0.6 -0.7 1.5 -0.5
Risk taking 1.5 2.2 7.5 0.3 2.7 0.6 1.7 1.3 -0.3 -1.2 0.8 2.3 -1.4
Ever had prostate specific antigen (PSA) test 0.2 0.3 1.0 0.1 0.0 -0.4 -0.3 0.7 -1.0 0.1 0.5 0.1 -0.8
Fractured/broken bones in last 5 years 0.3 0.4 1.5 0.6 -0.7 0.9 1.2 -0.0 0.1 -0.2 0.0 -0.8 -0.1
Age started oral contraceptive pill 0.7 0.8 2.6 -0.9 -1.6 -0.3 -0.7 -0.8 0.7 -1.1 0.5 -1.2 0.6
Diastolic blood pressure, automated reading 3.1 9.7 19.9 -4.5 -3.7 -3.7 -2.7 -0.8 -1.9 -3.6 4.0 -2.9 0.3
Ever depressed for a whole week 0.5 0.7 3.0 0.3 -0.5 -1.7 -0.4 0.8 -0.4 -0.2 0.3 0.3 -1.5
Unable to work because of sickness or disability 0.2 0.2 0.8 0.4 0.4 0.4 0.3 -0.8 0.2 0.5 -0.9 0.2 0.4
Commuting to job workplace: Cycle 2.3 2.7 8.6 -2.9 0.3 -1.8 -0.0 1.4 -0.6 -2.1 2.3 -0.7 -1.6
Myopia 1.2 1.7 4.5 -0.2 1.2 0.0 0.7 1.4 -2.1 -1.5 1.7 1.2 -1.3
Vascular/heart problems diagnosed by doctor 0.5 1.3 3.8 0.9 1.9 1.5 1.4 0.9 0.7 1.1 -0.6 1.1 -0.8
Cholesterol lowering medication 0.3 0.5 1.6 -0.2 0.4 1.0 0.5 -1.2 -0.1 0.5 -0.3 0.5 1.1
Medication: Omeprazole (e.g. Zanprol) 1.6 1.9 4.2 2.1 1.7 1.2 0.9 0.2 0.9 2.0 -1.5 1.5 -0.5
Pain experienced in last month 0.5 0.8 2.9 -1.3 -0.4 -1.1 -1.7 -0.9 -0.3 -0.5 0.1 -0.5 1.0
Supplements: Calcium 0.4 0.4 1.1 1.1 0.2 0.6 0.6 0.8 0.9 0.2 -0.4 0.1 -0.9
Basal cell carcinoma (self-reported) 1.5 1.8 5.4 2.2 1.3 2.3 1.0 -0.3 0.2 1.4 -0.6 1.6 0.5
Heart attack/myocardial infarction (self-reported) 0.9 1.1 3.6 -0.3 -0.7 -1.0 -1.6 -1.9 -0.1 0.0 -0.2 -1.1 1.5
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.9 1.0 0.2 0.2 0.2 -0.5 -0.7 -0.1 -0.3 -0.6 0.5
Heart disease (siblings) 0.7 0.8 2.8 -1.2 -1.7 -0.8 -0.2 -0.6 -0.2 -1.0 0.7 -1.0 0.5
Alcohol drinker status: Previous 0.6 0.6 2.6 -0.2 0.6 1.6 0.7 -0.7 0.4 0.3 -0.6 0.5 1.2
Pack years of smoking 1.6 2.3 4.9 0.2 2.0 1.6 1.9 1.7 -1.3 -0.9 1.1 2.2 -1.3
Impedance of whole body 1.3 6.4 11.5 3.4 2.6 1.9 2.1 1.8 1.4 3.4 -3.2 2.9 -1.5
Leg fat mass (left) 2.4 9.5 15.7 -3.4 -3.5 -3.5 -2.7 -1.4 -3.0 -4.0 3.8 -3.1 0.9
Arm predicted mass (left) 1.5 7.7 12.2 -3.5 -3.4 -3.4 -2.6 -1.1 -2.6 -3.0 3.0 -2.9 0.7