Hub : Genes

TMEM108

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Muscularis	0.1690	0.0700	0.0042	-0.004	NA	0.008	NA	0.002	0.74000	NA	0.09900	NA	0.230
2	GTEx	Skin Sun Exposed Lower leg	0.1010	0.0370	0.0031	0.007	NA	0.023	NA	0.002	0.07200	NA	0.00520	NA	0.190
3	METSIM	Adipose	0.0599	0.0245	0.0016	0.022	0.017	0.010	0.02	0.011	0.00025	0.00100	0.01000	5e-04	0.008
4	TCGA	Thyroid Carcinoma	0.0450	0.0200	0.0002	0.025	0.035	0.033	NA	0.003	0.00150	0.00022	0.00032	NA	0.160

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	2.2	3.5	13.5	-0.1	-0.7	-0.1	-3.7
Bipolar Disorder or Schizophrenia	3.0	7.4	26.8	1.4	-0.6	0.7	-5.2
Depressed Affect (Nagel 2018)	0.5	1.2	2.8	1.7	0.6	0.2	1.2
Depression (Nagel 2018)	0.3	0.4	0.7	0.8	0.6	-0.5	0.6
Intelligence (Savage-Jansen 2018)	2.2	6.7	14.4	1.0	-2.7	-2.0	3.8
Neuroticism (Nagel 2018)	0.9	2.1	4.3	1.6	2.1	0.8	0.9
Schizophrenia (2018)	2.2	4.5	13.5	1.9	-0.2	1.0	-3.7
Schizophrenia vs Biploar Disorder	1.4	1.8	5.6	-0.1	2.4	1.3	-0.4
Worry (Nagel 2018)	0.7	1.5	3.0	1.1	1.3	-0.1	1.7
Alzheimer’s Disease (in mother)	0.5	0.6	1.5	-0.3	1.2	0.4	0.7
Alzheimer’s Disease (in father)	0.2	0.3	0.7	0.5	0.8	-0.3	-0.3
Alzheimer’s Disease (including proxy)	0.3	0.5	0.8	0.2	0.9	-0.8	0.7
Crohns Disease (2017)	2.0	4.4	13.0	0.0	-2.2	-3.6	0.0
Irritable Bowel Disease (IBD)	1.1	2.7	5.4	0.2	-2.2	-2.3	0.4
Ulcerative Colitis (UC)	0.2	0.4	1.2	0.1	-1.1	-0.4	0.5
Major Depression (MDD)	0.0	0.1	0.1	-0.2	0.2	-0.4	0.1
Reaction Time	1.1	2.1	4.1	1.7	-0.8	-0.9	-2.0
Verbal and Numeric Reasoning (VNR)	1.3	3.2	6.5	0.7	-2.2	-0.9	2.5
Breast Cancer	0.6	1.5	3.9	-0.4	1.3	0.3	2.0
Ovarian Cancer	0.8	1.1	2.5	-1.3	0.1	-0.3	-1.6
Prostate Cancer	0.5	0.7	2.2	0.6	0.2	0.5	-1.5
Age at First Birth	1.5	2.1	4.7	-1.1	2.2	1.3	-1.0
Bipolar Disorder (2011)	1.2	1.1	2.9	-1.1	-0.1	-0.7	-1.7
Body Mass Index (BMI) (2010)	0.5	0.7	1.4	0.5	-0.2	-1.2	-1.1
Coronary Artery Disease (CAD)	0.9	1.1	1.9	-1.0	0.8	-1.4	-0.9
Crohns Disease (2012)	4.0	6.4	22.4	-1.2	-1.3	-4.7	-0.3
Mean Putamen Volume	0.3	0.4	0.6	0.8	-0.3	0.6	0.6
Fasting Glucose	0.6	0.7	2.2	1.5	-0.7	0.1	-0.3
HbA1C	0.1	0.1	0.3	0.6	-0.3	-0.3	-0.2
HDL Cholesterol	0.3	0.5	1.4	-1.2	0.2	0.7	0.5
LDL Cholesterol	0.4	0.7	2.2	0.3	-1.5	0.4	0.5
Lupus	1.0	1.5	4.0	-2.0	0.6	0.7	1.2
Neuroticism (2016)	1.1	1.6	2.7	1.6	1.2	1.5	0.2
Primary Biliary Cirrhosis	0.5	0.8	3.0	0.0	-1.7	-0.0	0.1
Rheumatoid Arthritis	1.2	1.6	3.9	-2.0	0.8	1.4	-0.3
Schizophrenia (2014)	2.0	4.4	14.7	1.6	-0.4	0.2	-3.8
Triglycerides	0.2	0.3	0.8	-0.1	-0.1	0.9	0.6
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.0	1.4	0.1	0.8	-0.8
Ulcerative Colitis	0.1	0.1	0.2	0.3	0.2	0.1	-0.4
Blood Eosinophil Count	0.1	0.9	2.1	-1.5	-1.1	-0.2	0.0
Blood Platelet Count	0.1	1.0	3.0	-1.7	1.0	-0.0	0.4
Blood Red Count	0.3	2.5	8.5	-1.1	0.5	-2.9	0.2
Blood White Count	0.3	2.2	6.1	-0.7	2.5	0.9	-1.2
Heel T-Score	0.4	3.0	8.8	-1.1	-0.5	-3.0	-1.4
BMI	0.3	1.5	5.0	0.5	-0.6	-0.6	2.2
Height	0.1	2.0	3.9	0.9	-1.6	-0.8	-2.0
Waist Hip Ratio (WHR)	0.0	0.1	0.3	0.0	-0.0	-0.5	0.3
Systolic Blood Pressure	0.3	1.3	1.8	-1.3	-1.2	-1.2	-0.7
Smoking Status	0.5	1.2	2.5	1.5	1.6	0.3	-0.1
Allergy or Eczema	0.7	1.9	3.6	-1.6	-1.9	-1.2	0.1
Cardiovascular Disease	0.2	0.8	1.4	0.2	-1.2	0.6	1.2
Hypothyroidism (self reported)	1.5	3.5	8.4	0.2	-2.9	-0.4	2.3
Respiratory disease	1.2	2.7	10.0	3.2	-0.7	0.6	-0.1
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.5	0.6	0.5	0.7	0.5
Lung FEV1/FVC ratio	0.5	2.6	3.4	-1.4	1.6	1.8	1.5
Lung FVC	0.7	3.4	5.4	-1.7	2.2	-0.2	-2.3
Neuroticism	0.8	1.9	4.1	1.5	2.0	0.6	0.9
Chronotype (morning person)	4.1	9.6	37.3	0.9	0.4	-0.2	-6.1
Hair Pigment	0.1	3.4	9.5	-3.1	0.6	-0.4	1.9
Tanning	0.0	0.1	0.2	-0.3	0.4	-0.4	-0.1
Hand grip strength (left)	1.9	5.1	9.6	0.4	2.0	2.5	-3.1
Number of treatments/medications taken	2.2	3.9	12.7	-0.7	-1.6	0.0	3.6
Average weekly spirits intake	0.1	0.1	0.4	-0.2	-0.4	0.2	-0.6
Sensitivity / hurt feelings	0.6	1.0	2.6	0.6	0.3	0.8	1.6
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.9	0.6	0.9	-1.4	-0.4
Hearing difficulty/problems: Yes	0.6	0.9	2.3	1.5	-0.8	0.2	0.8
Relative age of first facial hair	0.5	0.9	2.0	-1.4	-1.0	0.9	0.2
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	4.7	0.7	0.2	-0.6	2.2
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.6	0.7	-0.8	-1.3	-0.6
Ever had hysterectomy (womb removed)	1.0	1.1	2.5	1.4	-1.6	-0.2	-0.3
Systolic blood pressure, automated reading	0.6	1.6	3.1	1.3	-1.8	-1.0	-1.0
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	3.5	0.8	-1.1	0.8	1.9
Angina	0.9	1.2	1.8	-0.2	-1.1	1.2	1.4
Medication for hormone replacement therapy	1.5	1.7	4.0	0.7	1.0	1.1	-2.0
Vitamin and mineral supplements	0.8	1.1	3.5	0.8	-0.5	0.1	1.9
Supplements: Zinc	0.1	0.1	0.4	-0.1	0.4	-0.0	-0.6
Medication: Co-codamol	0.4	0.5	0.7	0.7	-0.8	-0.4	0.7
Medication: Metformin	1.9	2.6	6.3	0.9	2.5	1.6	-0.9
Diabetes (father)	1.3	1.6	4.0	0.4	-0.4	2.0	1.4
Diabetes (mother)	0.3	0.4	0.8	0.5	-0.9	0.7	0.2
Severe depression (siblings)	0.7	0.8	1.3	-1.1	0.7	-0.0	1.2
Pack years adult smoking proportion	1.4	2.1	5.7	-1.4	2.4	0.0	0.9
Impedance of leg (right)	0.3	1.4	5.5	-0.0	0.1	2.4	-0.1
Leg fat-free mass (left)	0.1	0.5	1.1	0.6	-0.1	-1.0	-0.6
Trunk fat percentage	0.7	2.7	4.9	1.1	-2.2	1.0	1.9
Hand grip strength (right)	1.0	2.6	3.9	-0.3	1.8	1.8	-2.0
Townsend deprivation index at recruitment	0.9	1.2	4.2	2.0	-0.5	0.1	0.6
Current tobacco smoking	0.6	0.9	2.0	0.1	1.3	-1.4	0.2
Average weekly fortified wine intake	0.7	0.8	2.1	-0.7	-0.7	0.4	-1.4
Maternal smoking around birth	0.6	0.9	1.7	-1.3	1.1	-0.3	-0.7
Fed-up feelings	1.2	2.1	4.1	1.9	2.0	0.7	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.5	0.0	0.0	-0.7	-0.1
Relative age voice broke	0.8	1.2	3.5	0.7	-1.9	0.9	-0.4
Taking other prescription medications	1.9	2.9	7.9	-0.2	-1.8	-0.8	2.8
Age when periods started (menarche)	1.3	3.1	7.5	-2.1	-0.5	2.7	0.1
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.3	1.2	-0.6	-0.4	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	4.1	-0.8	0.4	-2.0	-0.3
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.6	0.5	-0.6	-0.8	-0.2
Qualifications: CSEs or equivalent	1.1	1.4	3.9	-2.0	0.8	0.9	0.5
Serious illness, injury or assault to yourself	0.2	0.2	0.3	0.6	0.5	-0.4	0.5
High blood pressure	0.8	2.1	4.7	0.2	-2.2	-2.0	-0.2
Hayfever, allergic rhinitis or eczema	0.9	2.0	4.1	-2.0	-1.7	-1.0	0.0
Multivitamins +/- minerals	0.9	1.2	3.4	-0.4	0.3	-1.1	-1.8
Stomach or abdominal pain in last month	0.5	0.6	1.6	0.9	0.1	0.4	1.3
Supplements: Glucosamine	2.3	3.0	11.7	-3.4	-0.6	-0.1	-0.2
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.2	-0.9	-0.1	-1.0	1.1
Medication: Atenolol	1.5	1.9	5.6	-0.7	-2.4	-0.8	0.8
Medication: Levothyroxine sodium	1.3	2.2	5.2	-0.5	-1.8	0.3	2.3
Sitting height	0.2	1.7	5.8	0.5	0.4	-0.9	-2.4
Chronic bronchitis/emphysema (father)	0.8	0.9	2.5	-0.3	-0.2	-1.6	1.0
High blood pressure (mother)	1.5	2.0	5.2	1.5	-0.2	0.8	-2.3
Body mass index (BMI)	0.4	1.6	3.0	1.1	-1.2	-0.8	1.7
Impedance of leg (left)	0.4	2.1	7.7	-0.3	-0.3	2.8	-0.7
Leg predicted mass (left)	0.1	0.5	1.0	0.6	-0.1	-1.0	-0.7
Trunk fat mass	0.3	1.5	3.0	0.9	-1.7	0.7	1.3
Waist circumference	0.2	0.6	1.1	1.0	-0.7	-0.1	0.9
Number of incorrect matches in round	1.0	1.7	5.9	-2.4	0.2	-0.1	-0.9
Past tobacco smoking	0.8	1.5	4.2	-1.0	-1.0	-2.1	0.1
Alcohol usually taken with meals	1.0	1.6	4.2	-0.1	-1.3	-0.7	-2.0
Nervous feelings	1.3	2.5	6.1	0.2	1.9	-0.7	2.5
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.6	0.4	0.8	-0.4	0.6
Hearing difficulty/problems with background noise	0.1	0.2	0.4	0.2	-0.7	-0.3	0.5
Hair/balding pattern: Pattern 2	0.8	1.0	2.3	0.9	1.0	-0.2	-1.5
Had menopause	1.5	1.9	5.4	0.7	-2.3	-0.9	0.8
Had other major operations	0.2	0.2	0.5	0.0	-0.3	-0.7	0.5
Forced vital capacity (FVC)	0.7	2.5	3.7	-1.7	1.9	0.5	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.5	0.2	0.3	-1.2	-0.1
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.3	0.5	1.5	-0.7	-0.1
Qualifications: None of the above	0.2	0.3	0.5	0.5	0.7	0.7	0.2
Financial difficulties in last 2 years	2.0	2.7	4.1	0.3	1.7	-2.0	2.0
Mouth/teeth dental problems	0.1	0.2	0.3	-0.4	-0.6	-0.4	-0.4
Heart attack	0.2	0.2	0.5	-0.4	-0.4	-0.1	-0.7
Allergy	0.3	0.6	1.8	-0.9	1.3	-0.2	-0.1
Pain all over the body in last month	2.5	2.7	5.8	-2.4	-0.1	-1.5	1.6
Diabetes (self-reported)	0.6	0.9	2.8	0.2	1.7	0.6	0.6
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	1.8	-0.6	-0.8	-1.4	-1.2
Medication: Ramipril	0.2	0.2	0.6	-0.1	0.0	-0.8	0.5
Medication: Simvastatin	3.0	4.4	14.3	-0.6	-1.4	0.9	3.8
Fluid intelligence score	1.6	3.2	7.5	1.1	-2.7	-1.6	1.3
Illnesses of siblings	0.2	0.3	1.2	0.3	0.2	1.1	0.3
Neuroticism score	1.1	2.4	5.5	1.2	2.3	0.2	1.6
Weight	0.1	0.6	1.1	0.9	-1.0	-0.6	0.4
Impedance of arm (right)	0.2	1.0	3.5	-0.4	0.4	1.9	-0.1
Arm fat percentage (right)	0.4	1.7	3.9	1.0	-1.1	0.7	2.0
Trunk fat-free mass	0.2	1.1	2.2	0.6	0.5	-1.2	-1.5
Hip circumference	0.1	0.5	1.5	1.2	-0.8	0.1	0.1
Time employed in main current job	0.2	0.2	0.9	-1.0	-0.1	-0.0	-0.0
Alcohol intake versus 10 years previously	1.1	1.7	2.8	1.7	-1.1	-0.6	1.5
Father’s age at death	1.3	1.8	4.8	1.3	-0.6	2.2	0.4
Worrier / anxious feelings	0.2	0.4	0.6	0.8	0.7	-0.4	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	3.5	-0.0	1.9	0.1	0.6
Falls in the last year	1.9	2.5	9.5	-0.1	-0.7	-0.1	3.1
Hair/balding pattern: Pattern 3	0.6	0.8	3.1	-0.3	-1.8	0.4	-0.2
Number of live births	2.1	3.0	8.0	-0.3	-1.6	-1.1	2.8
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	4.1	-2.0	1.9	1.4	-1.6
Pulse rate	1.2	2.1	4.5	0.3	2.1	1.9	-0.5
Happiness	1.2	1.5	3.6	0.7	1.2	-0.5	-1.9
Noisy workplace	0.5	0.6	1.2	-0.7	1.1	0.8	0.2
Qualifications: A levels/AS levels or equivalent	1.0	2.2	5.8	0.5	0.9	2.4	-1.3
Serious illness, injury or assault of a close relative in last 2 years	2.1	2.5	8.0	0.5	-2.8	-1.3	-0.1
Mouth/teeth dental problems: Dentures	2.6	4.3	12.9	0.9	-1.9	0.2	3.6
Asthma	1.0	1.9	6.5	2.5	-1.0	0.4	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	3.8	-1.0	-1.9	0.2	0.0
Medication: Cholesterol lowering	1.9	3.0	7.3	-1.7	-1.3	-0.3	2.7
Depression (self-reported)	0.3	0.3	0.9	1.0	0.6	0.1	-0.4
Medication: Lansoprazole	1.8	2.0	7.3	0.9	-0.2	0.2	2.7
Prospective memory result	1.1	1.3	2.9	-0.6	1.1	1.7	-0.8
Lung cancer (father)	1.2	1.4	2.5	-1.6	1.0	-1.4	0.2
Illnesses of mother	0.9	1.1	2.3	-1.1	0.1	-0.9	1.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.3	5.6	-2.4	1.9	1.4	-1.5
Pulse wave Arterial Stiffness index	0.1	0.1	0.3	0.0	0.6	0.1	0.0
Impedance of arm (left)	0.2	1.0	3.9	-0.3	-0.2	2.0	0.2
Arm fat mass (right)	0.3	1.3	2.2	1.1	-1.5	0.1	1.3
Trunk predicted mass	0.2	1.1	2.6	0.7	0.5	-1.1	-1.6
Standing height	0.2	2.3	9.1	-0.0	0.2	0.5	-3.0
Length of working week for main job	0.4	0.5	0.7	0.9	0.8	0.2	-0.7
Exposure to tobacco smoke at home	1.5	1.7	5.9	0.2	2.4	-0.9	-0.5
Breastfed as a baby	0.6	0.7	1.0	-1.0	-0.0	0.9	-1.0
Tense / ‘highly strung’	1.4	2.4	4.4	0.8	1.6	2.1	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	3.1	1.5	1.0	-0.9	1.8
Hair/balding pattern: Pattern 4	0.6	1.5	3.6	-1.4	0.4	-0.5	1.9
Birth weight of first child	1.0	1.9	3.8	1.9	-1.9	0.4	0.1
Peak expiratory flow (PEF)	0.4	0.9	1.7	-0.6	1.0	1.3	-0.8
Pulse wave reflection index	0.2	0.2	0.5	-0.7	-0.1	-0.6	-0.1
Ever highly irritable/argumentative for 2 days	1.0	1.3	3.0	-0.6	1.7	-0.5	-1.2
Loud music exposure frequency	2.4	2.7	6.7	-2.6	1.5	1.1	-0.7
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.0	-1.4	0.3	1.2	0.7
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	3.5	0.6	1.8	-1.9	-0.9
Blood clot in the leg (DVT)	0.9	1.2	3.2	0.2	1.8	1.1	-0.0
Medication: Paracetamol	0.5	0.8	2.0	0.1	-0.5	-1.0	1.4
Headache pain in last month	0.3	0.6	1.9	0.5	-0.3	1.4	-0.3
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	3.7	1.1	1.4	1.3	-1.9
Glaucoma (self-reported)	1.6	1.9	4.1	0.1	-2.0	0.7	1.7
Gout (self-reported)	1.5	2.1	7.4	-0.3	-0.9	-2.7	0.2
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	5.2	0.0	-2.3	-0.4	1.8
Medication: Amlodipine	1.5	2.0	4.1	0.7	-1.6	-2.0	0.9
Medication: Ventolin 100micrograms inhaler	1.8	2.3	3.9	1.2	2.0	1.8	-0.9
Birth weight	1.1	2.5	9.1	-0.8	-0.3	-0.4	3.0
Chronic bronchitis/emphysema (mother)	2.1	2.5	8.0	0.5	0.4	-2.8	-1.2
High blood pressure (siblings)	0.9	1.3	1.8	-1.2	-0.8	-1.1	-1.3
Forced vital capacity (FVC), Best measure	0.7	2.4	4.5	-1.7	1.4	0.4	-2.1
Body fat percentage	0.6	2.5	3.5	1.4	-1.9	1.0	1.9
Leg fat percentage (right)	0.6	2.3	3.6	1.7	-1.3	1.0	1.9
Arm fat-free mass (right)	0.1	0.7	1.7	0.8	-0.4	-0.6	-1.3
Exposure to tobacco smoke outside home	0.5	0.7	1.3	0.9	0.4	-1.2	0.8
Comparative body size at age 10	0.2	0.7	2.0	-1.4	0.6	-0.1	-0.6
Number of full brothers	0.4	0.5	1.2	-0.7	0.3	1.1	-0.4
Worry too long after embarrassment	0.9	1.5	4.9	0.9	2.2	0.6	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.2	1.5	-0.1	-1.2	1.3
Wheeze or whistling in the chest in last year	0.8	1.4	2.8	1.7	-0.5	-0.5	1.6
Number of children fathered	0.3	0.3	0.9	-0.0	-1.0	-0.5	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	2.2	-0.1	-0.2	-1.3	-1.5
Age at first live birth	1.8	3.1	8.4	-2.9	0.0	-0.9	-1.8
Pulse wave peak to peak time	0.1	0.1	0.5	-0.0	-0.7	0.0	-0.2
Health satisfaction	0.1	0.1	0.3	0.1	0.5	-0.3	0.1
Shortness of breath walking on level ground	0.8	0.9	1.3	0.9	-0.9	-1.0	1.2
Qualifications: College or University degree	0.7	2.3	8.5	0.5	0.0	0.6	-2.9
Eye problems/disorders: None of the above	0.9	1.0	3.8	-0.4	2.0	-0.2	-0.3
Mouth/teeth dental problems: Loose teeth	0.6	0.8	1.0	1.0	0.7	0.8	1.0
Emphysema/chronic bronchitis	1.0	1.1	2.3	1.4	1.5	-0.1	-0.1
Medication for pain relief, constipation, heartburn	1.5	2.5	5.3	-0.3	2.1	0.4	-2.3
Neck or shoulder pain in last month	0.4	0.6	1.8	0.0	0.6	-1.3	-0.6
Medication: Blood pressure	1.0	1.8	2.4	-1.5	-1.3	-1.5	0.9
Angina (self-reported)	0.8	1.0	1.5	-0.0	-1.0	1.2	1.2
Migraine (self-reported)	1.2	1.4	3.3	-1.8	-0.9	0.8	1.0
Medication: Ibuprofen	0.6	0.7	1.9	-0.8	-1.4	0.3	-0.1
Medication: Allopurinol	0.5	0.6	1.6	-0.6	-0.5	-1.3	0.6
Medication: Omeprazole	0.8	1.0	1.6	0.6	-1.0	-1.3	1.0
Medication: Seretide 50 evohaler	0.7	0.8	1.8	0.9	0.7	-1.3	0.3
Mean time to correctly identify matches	1.0	1.9	4.3	1.0	-2.1	-1.1	-1.1
Heart disease (mother)	0.9	1.1	2.7	-0.7	0.4	1.0	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.8	-0.4	-0.9	-0.8	0.4
Whole body fat mass	0.4	1.8	3.5	1.1	-1.9	0.6	1.5
Leg fat mass (right)	0.3	1.1	1.7	1.0	-1.3	0.4	1.3
Arm predicted mass (right)	0.2	0.9	1.3	0.8	-0.9	-0.9	-1.1
Pulse rate, automated reading	0.5	1.6	4.9	0.4	2.2	0.9	-0.7
Alcohol intake frequency.	1.7	4.0	13.9	1.1	0.6	-3.7	-0.7
Comparative height size at age 10	0.1	0.8	1.2	0.8	-1.0	1.1	-0.7
Number of full sisters	0.1	0.1	0.3	0.2	-0.3	0.2	0.6
Suffer from ‘nerves’	0.4	0.6	1.6	0.3	0.7	-1.3	0.6
Overall health rating	1.5	3.1	11.1	0.6	-1.0	0.2	3.3
Chest pain or discomfort	0.7	1.0	1.9	-1.4	0.3	1.1	1.0
Had major operations	1.0	1.2	4.0	-0.5	-2.0	0.2	0.6
Age at last live birth	1.1	1.6	5.8	-2.4	-0.2	-0.5	0.5
Family relationship satisfaction	1.0	1.2	3.2	-0.4	1.8	0.4	-1.1
Leg pain on walking	0.6	0.8	1.6	0.7	1.3	-0.7	-0.6
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	4.0	-0.6	2.0	-1.4	-0.5
Commuting to job workplace: Car/motor vehicle	1.6	1.9	6.5	-0.9	0.3	-0.0	2.5
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.0	-0.5	-0.4	1.0	-0.5
Medication: Aspirin	0.5	0.6	1.5	0.2	-1.2	0.2	0.9
Supplements: Vitamin C	0.5	0.6	1.2	-1.1	0.4	-0.3	-1.1
Knee pain experienced in last month	0.3	0.5	0.8	0.9	-0.8	-0.8	0.1
Hypertension (Self-reported)	0.7	1.8	4.3	0.0	-2.1	-1.7	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.3	0.5	0.6	-0.5	1.2
Illnesses of father: Heart disease	0.9	1.2	2.2	0.6	-1.2	0.9	1.5
Illnesses of siblings: Diabetes	0.5	0.6	2.0	0.5	0.4	0.0	1.4
Smoking status: Previous	0.3	0.5	1.1	1.1	0.2	0.9	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	6.6	-0.9	0.1	-0.7	-2.6
Whole body fat-free mass	0.2	0.9	1.8	0.7	0.2	-1.1	-1.4
Leg fat-free mass (right)	0.1	0.6	1.1	0.5	-0.2	-1.0	-1.0
Arm fat percentage (left)	0.5	2.0	4.7	0.9	-1.4	0.6	2.2
Average weekly red wine intake	0.6	0.9	2.1	-1.4	-0.9	0.1	0.8
Handedness (chirality/laterality): Left-handed	0.9	1.1	3.3	0.2	1.1	-0.2	-1.8
Mood swings	0.3	0.6	1.2	0.7	1.1	0.5	0.6
Loneliness, isolation	1.2	1.7	2.7	1.3	1.6	-0.1	-1.6
Long-standing illness, disability or infirmity	1.3	2.0	4.6	0.9	-1.3	-0.8	2.1
Ever had bowel cancer screening	1.6	1.8	6.0	0.1	-1.1	-0.3	2.4
Diabetes diagnosed by doctor	0.5	0.9	1.6	0.8	1.3	1.0	0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	3.3	-1.1	1.8	-0.3	0.3
Friendships satisfaction	0.2	0.2	0.3	0.5	0.6	-0.6	-0.0
Qualifications: nursing, teaching	1.0	1.6	2.3	0.7	-1.3	-1.5	-1.4
Commuting to job workplace: Walk	2.0	2.1	5.2	-0.6	2.3	0.1	-1.7
Eye problems/disorders: Cataract	0.6	0.7	1.6	-0.2	-1.3	-0.6	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.5	-0.3	0.7	-0.4	-0.6
Medication for cholesterol	0.6	0.9	2.0	-0.9	1.4	-0.8	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	4.8	1.1	-2.2	0.5	0.6
Back pain experienced in last month	0.3	0.4	1.4	-0.2	-0.3	-0.2	1.2
Mineral and other dietary supplements	0.7	0.9	2.8	1.7	-0.1	0.7	0.7
Breast cancer (self-reported)	1.2	1.4	3.8	0.7	-0.4	-1.9	1.1
Asthma (self-reported)	0.8	1.5	5.2	2.3	-0.7	0.6	-0.3
Osteoporosis (self-reported)	0.9	1.2	3.7	-1.9	-0.6	-0.0	0.7
Osteoarthritis (self-reported)	2.1	2.8	5.2	-2.0	-1.1	-2.3	0.9
Medication: Aspirin	0.4	0.5	1.1	-0.1	-0.8	0.4	1.0
Medication: Gliclazide	0.5	0.5	1.0	-0.6	-1.0	-0.0	0.8
Illnesses of father: None of the above (group 1)	1.5	1.9	4.1	0.3	2.0	0.4	-1.8
Smoking status: Current	0.4	0.6	2.0	0.1	1.4	-0.6	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.5	-0.0	0.1	0.7	0.6
Whole body water mass	0.2	0.9	1.9	0.6	0.2	-1.1	-1.4
Leg predicted mass (right)	0.1	0.6	1.0	0.5	-0.2	-0.9	-1.0
Arm fat mass (left)	0.3	1.4	2.4	0.9	-1.6	0.1	1.6
Number of self-reported non-cancer illnesses	1.4	2.4	6.7	0.7	-1.5	-0.5	2.6
Average weekly champagne plus white wine intake	1.6	2.2	6.2	0.0	1.5	0.7	-2.5
Miserableness	0.7	1.2	2.8	-0.3	-0.6	-1.7	1.2
Guilty feelings	0.7	1.0	3.7	-0.2	1.9	0.2	-0.5
Wears glasses or contact lenses	3.2	3.7	6.8	0.2	-2.5	-1.3	2.6
Ever taken oral contraceptive pill	1.0	1.2	1.9	-0.6	1.1	-1.4	1.1
Hearing aid user	0.6	0.7	2.2	1.5	-0.3	-0.7	-0.1
Mother’s age at death	0.6	0.8	1.9	1.4	0.8	-0.1	-0.7
Financial situation satisfaction	0.8	1.0	2.8	-0.5	1.7	-1.0	-0.4
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.5	1.6	-0.1	0.2	0.7
Commuting to job workplace: Public transport	0.8	0.9	2.2	0.7	-1.5	0.4	-1.0
Eye problems/disorders: Glaucoma	2.1	2.4	4.2	1.0	-2.0	0.6	2.0
Medication: Blood pressure	1.2	2.4	8.2	0.0	-2.9	-0.9	0.7
Pain type(s) experienced in last month: Hip pain	1.0	1.3	4.1	0.4	-0.9	-2.0	0.3
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.9	-0.3	0.2	0.3	-1.7
High cholesterol (Self-reported)	1.5	2.7	7.8	-0.6	-1.6	0.6	2.8
Medication: Bendroflumethiazide	0.8	1.2	2.8	-1.4	-0.2	-0.1	1.7
Medication: Paracetamol	0.7	1.0	2.8	-0.4	-0.2	-1.1	1.7
Medication: Lisinopril	0.7	0.9	2.5	0.9	-1.6	0.2	0.3
Medication: Atorvastatin	0.6	0.7	2.7	0.1	-0.1	0.5	1.6
Illnesses of father: High blood pressure	1.6	2.0	3.6	-1.9	-1.4	1.5	-0.4
Alcohol drinker status: Never	1.4	1.7	3.2	-1.4	-1.1	-1.8	0.8
Ever smoked	1.3	2.3	4.9	0.5	1.9	2.2	-0.8
Basal metabolic rate	0.1	0.6	1.0	0.7	-0.1	-0.9	-1.0
Leg fat percentage (left)	0.6	2.0	3.0	1.4	-1.7	1.1	1.5
Arm fat-free mass (left)	0.2	1.0	1.9	0.7	-0.2	-1.2	-1.4
Number of operations (self-reported)	0.4	0.6	1.0	0.8	-1.0	0.8	0.1
Average weekly beer plus cider intake	1.2	1.7	3.6	0.5	0.9	1.9	1.4
Irritability	1.6	2.7	7.4	1.3	2.7	1.0	-0.8
Risk taking	1.0	1.5	4.2	0.2	0.8	1.1	-2.1
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.8	0.9	-0.7	-1.3	0.4
Fractured/broken bones in last 5 years	0.2	0.3	0.8	-0.4	-0.9	-0.4	0.3
Age started oral contraceptive pill	0.9	1.2	2.8	-0.7	-1.7	0.2	-1.2
Diastolic blood pressure, automated reading	0.5	1.5	2.9	1.3	-0.4	-1.1	-1.7
Ever depressed for a whole week	0.9	1.2	2.9	0.3	1.7	-0.3	-1.3
Unable to work because of sickness or disability	1.5	1.9	5.2	-1.4	0.7	0.2	2.3
Commuting to job workplace: Cycle	0.9	1.0	2.7	0.1	0.8	0.9	-1.6
Myopia	0.3	0.4	0.7	-0.1	-0.5	-0.8	0.8
Vascular/heart problems diagnosed by doctor	0.8	2.1	5.7	-0.1	2.4	1.6	-0.2
Cholesterol lowering medication	2.3	3.3	9.4	0.9	-1.1	1.4	3.1
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	2.0	0.9	-1.4	-0.6	0.8
Pain experienced in last month	0.3	0.5	1.2	-0.8	1.1	-0.0	-0.6
Supplements: Calcium	0.3	0.4	0.7	0.4	-0.1	-0.8	-0.8
Basal cell carcinoma (self-reported)	0.6	0.7	1.5	1.2	-0.9	-0.0	0.8
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.7	-0.4	-0.5	-0.1	-0.8
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	3.1	0.8	1.8	1.3	-0.2
Heart disease (siblings)	0.3	0.4	0.6	0.6	0.7	0.5	0.8
Alcohol drinker status: Previous	0.7	0.8	1.3	1.1	0.2	-1.1	-0.9
Pack years of smoking	1.1	1.5	3.5	-1.2	1.9	0.1	1.1
Impedance of whole body	0.3	1.5	5.6	-0.5	-0.2	2.4	-0.4
Leg fat mass (left)	0.3	1.0	2.1	0.8	-1.5	0.6	1.0
Arm predicted mass (left)	0.2	1.0	2.0	0.9	-0.4	-1.0	-1.4