TWAS hub - CADM1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Left Ventricle	0.1803	0.0737	8.2e-03	0.131	NA	0.060	NA	0.118	1.9e-07	NA	4.0e-04	NA	7.9e-07
2	GTEx	Stomach	0.1690	0.0610	2.8e-03	0.041	NA	0.022	NA	0.033	4.6e-03	NA	3.1e-02	NA	1.0e-02
3	GTEx	Thyroid	0.5530	0.0570	0.0e+00	0.527	NA	0.503	NA	0.530	9.0e-47	NA	7.9e-44	NA	2.9e-47
4	METSIM	Adipose	0.0752	0.0266	2.9e-04	0.002	0.008	0.018	0.013	0.002	1.4e-01	1.6e-02	8.3e-04	3.4e-03	1.3e-01
5	YFS	Blood	0.1120	0.0207	0.0e+00	0.114	0.103	0.108	0.115	0.111	3.0e-35	1.0e-31	1.9e-33	1.1e-35	1.7e-34
6	TCGA	Thyroid Carcinoma	0.1000	0.0300	8.5e-08	0.051	0.092	0.080	NA	0.054	1.1e-05	2.7e-09	3.2e-08	NA	5.5e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Heel T-Score	21.7	172.7	289.0	12.0	0.0	-17.0	12.8	-16.9	-12.4
Heel bone mineral density (BMD) T-score, automated (left)	12.3	27.9	50.1	4.4	0.9	-6.5	5.3	-7.1	-5.2
Heel bone mineral density (BMD) T-score, automated (right)	12.2	27.9	46.5	4.3	1.7	-6.8	5.0	-6.8	-5.4
Angina (self-reported)	8.5	11.1	22.2	-0.1	1.4	4.7	-3.3	3.5	4.5
Chest pain or discomfort	8.5	12.2	27.4	-0.2	-2.0	4.7	-2.0	4.0	5.2
Angina	8.1	10.7	21.0	-0.1	1.5	4.6	-3.4	3.3	4.3
Number of full sisters	5.8	7.0	15.0	-1.0	1.2	3.6	0.3	3.9	3.4
Medication for cholesterol	5.4	8.2	16.2	1.1	1.3	-4.0	2.8	-3.3	-3.4
Unable to work because of sickness or disability	5.3	6.9	16.2	0.4	1.3	3.2	0.6	4.0	3.5
Supplements: Glucosamine	4.9	6.3	13.8	2.0	-1.1	-3.7	1.7	-3.0	-2.7
Heart attack	4.7	6.0	9.2	-2.2	2.1	3.0	-2.8	2.4	1.9
Shortness of breath walking on level ground	4.6	5.5	11.1	-1.9	0.7	3.3	0.0	2.8	3.2
Illnesses of siblings	4.5	6.3	19.4	-1.5	-0.4	-4.4	0.8	-3.3	-2.1
Age at First Birth	4.3	6.3	14.9	1.7	0.3	-3.7	0.5	-3.9	-2.4
BMI	4.1	23.8	56.1	0.4	2.3	6.8	-3.1	7.5	5.1
Stomach or abdominal pain in last month	4.1	5.1	12.7	-0.2	-0.9	3.6	-0.0	2.6	3.2
Number of operations (self-reported)	3.9	5.7	13.4	-1.7	0.6	3.7	-0.7	3.3	2.5
Heart attack/myocardial infarction (self-reported)	3.9	5.0	8.4	-2.0	1.7	2.9	-2.7	2.1	1.6
Body Mass Index (BMI) (2010)	3.8	5.2	8.0	1.4	2.3	2.3	-1.8	2.8	2.8
Body mass index (BMI)	3.7	15.9	38.8	0.6	1.2	5.7	-2.3	6.2	4.2
Cholesterol lowering medication	3.7	5.5	15.8	-1.3	-0.1	2.4	-4.0	1.6	2.7
Medication: Metformin	3.5	4.9	11.1	0.4	0.3	3.3	-2.0	2.6	2.7
Current tobacco smoking	3.4	5.5	13.6	-3.7	0.3	2.6	-0.7	2.7	2.2
Falls in the last year	3.4	4.6	10.6	-1.2	-1.0	2.1	1.1	3.0	3.2
Handedness (chirality/laterality): Left-handed	3.4	4.1	8.8	0.3	0.8	-2.5	-1.3	-3.0	-2.7
Average weekly spirits intake	3.3	4.1	11.5	-3.4	-2.0	1.6	-0.4	1.7	1.9
Ever had hysterectomy (womb removed)	3.3	3.7	9.0	0.7	-0.8	2.5	-1.3	2.1	3.0
Age at last live birth	3.3	4.7	13.9	-0.5	0.7	-3.1	-0.1	-3.7	-2.0
Qualifications: NVQ or HND or HNC or equivalent	3.3	4.0	10.0	1.1	-0.5	2.8	-3.2	1.9	1.1
Pain type(s) experienced in last month: Hip pain	3.2	4.1	10.1	0.0	-0.7	3.2	-0.3	2.2	3.0
Medication: Atorvastatin	3.2	3.9	12.0	-2.8	3.5	0.6	-1.9	-0.1	0.1
Schizophrenia vs Biploar Disorder	3.1	4.0	9.4	-1.8	-1.6	1.5	-1.0	2.4	3.1
Waist circumference	3.1	11.3	26.8	-0.4	2.3	4.7	-1.4	5.2	3.4
Impedance of arm (right)	3.0	14.0	29.2	-0.3	1.7	-5.2	3.1	-5.4	-3.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.0	3.5	8.0	-1.0	-0.9	2.0	-0.7	2.5	2.8
Impedance of whole body	3.0	15.4	33.1	-0.5	1.3	-5.6	3.0	-5.8	-4.1
Impedance of leg (left)	2.9	14.2	32.2	0.4	0.3	-5.4	2.8	-5.7	-4.0
High blood pressure (siblings)	2.9	4.2	13.4	0.9	0.2	3.7	-0.6	2.9	1.5
Comparative body size at age 10	2.9	8.1	20.4	1.7	0.4	4.5	-3.6	2.7	2.2
Impedance of leg (right)	2.8	13.3	29.1	0.0	0.2	-5.2	3.0	-5.4	-3.8
Qualifications: College or University degree	2.8	8.9	17.9	-0.7	1.9	-4.2	1.2	-4.0	-3.7
Fractured/broken bones in last 5 years	2.8	3.6	7.9	-0.8	-0.1	2.1	-1.3	2.8	2.6
Hypothyroidism (self reported)	2.7	6.1	16.2	0.9	-0.4	4.0	-1.5	2.6	3.2
Medication: Ramipril	2.7	3.4	9.0	-1.6	-0.7	2.2	-3.0	1.2	1.5
Heart disease (siblings)	2.7	3.3	10.9	0.9	0.9	3.3	-1.3	1.7	1.7
Age when periods started (menarche)	2.6	6.3	13.6	-0.4	0.7	-3.7	2.7	-3.3	-2.4
Impedance of arm (left)	2.6	12.0	24.2	-0.6	1.6	-4.9	2.9	-4.9	-3.6
Smoking status: Current	2.6	4.2	11.0	-3.3	0.4	2.2	-0.4	2.4	1.8
Arm fat mass (left)	2.6	10.7	25.8	1.1	2.3	4.4	-1.6	5.1	3.2
Medication: Paracetamol	2.6	4.1	9.5	0.6	-1.5	3.1	2.1	2.5	1.2
Medication: Atenolol	2.5	3.2	8.1	-0.1	-0.7	2.8	-1.9	1.8	1.9
Eye problems/disorders: None of the above	2.5	2.9	6.5	-0.4	2.6	-1.4	2.1	-0.7	-1.9
Alzheimer’s Disease (in mother)	2.4	2.8	6.1	-1.6	0.1	-2.2	0.5	-2.5	-1.8
Qualifications: A levels/AS levels or equivalent	2.4	5.4	13.4	-1.3	2.1	-2.9	0.6	-3.7	-2.0
Arm fat mass (right)	2.4	10.0	23.6	1.5	2.1	4.2	-1.4	4.9	3.1
Length of working week for main job	2.4	2.7	8.8	-1.4	1.3	0.3	-3.0	1.5	1.0
Medication: Paracetamol	2.4	4.0	9.6	0.9	-0.3	3.1	2.0	2.8	1.2
Mouth/teeth dental problems: Loose teeth	2.4	2.9	4.8	-1.7	0.6	1.8	-1.7	2.2	1.8
Leg fat mass (right)	2.4	9.1	21.1	1.1	2.0	4.2	-1.1	4.6	3.2
Arm fat percentage (left)	2.4	9.7	22.3	0.8	2.6	4.0	-1.4	4.7	3.2
Pain experienced in last month	2.4	4.0	10.4	-0.9	-0.2	-2.6	0.7	-3.2	-2.3
Leg fat mass (left)	2.4	9.2	20.8	1.4	2.0	4.2	-1.2	4.6	3.1
Neuroticism (2016)	2.3	3.3	7.8	0.4	-1.0	-2.2	-0.8	-2.3	-2.8
Pack years adult smoking proportion	2.3	3.5	8.0	-2.8	1.6	1.8	-1.6	1.4	1.7
Nervous feelings	2.2	4.1	9.5	1.6	-0.5	-2.4	-0.4	-3.1	-2.5
Had other major operations	2.2	2.7	5.1	-2.3	-0.3	2.2	-0.5	2.1	1.4
Arm fat percentage (right)	2.2	8.7	19.1	1.1	2.4	3.9	-1.4	4.4	3.0
Father’s age at death	2.2	3.0	8.6	1.7	-1.3	-1.3	2.9	-0.8	-1.5
Back pain experienced in last month	2.2	3.1	6.8	0.7	-1.7	2.2	-0.8	2.6	1.7
Leg fat percentage (left)	2.2	7.9	17.9	0.7	1.9	3.8	-1.2	4.2	3.1
Hypothyroidism/myxoedema (self-reported)	2.1	4.1	9.1	0.1	-0.7	3.0	-1.6	1.9	3.0
Number of full brothers	2.1	2.7	8.1	0.0	-0.6	2.5	0.3	2.9	1.2
Neck or shoulder pain in last month	2.1	3.0	5.8	1.3	0.7	2.2	-0.5	2.2	2.4
Medication: Seretide 50 evohaler	2.1	2.5	6.2	-0.1	-0.2	1.9	0.6	2.5	2.1
Severe depression (siblings)	2.0	2.2	5.2	0.1	-0.5	1.5	1.8	1.6	2.3
Leg fat percentage (right)	2.0	7.4	17.6	0.4	1.9	3.6	-0.9	4.2	3.1
Eye problems/disorders: Cataract	2.0	2.3	4.8	1.4	-2.2	1.2	-1.9	0.6	1.4
Medication: Blood pressure	2.0	3.9	11.4	-1.2	-0.5	3.4	-1.9	1.7	1.9
Pack years of smoking	2.0	2.9	8.1	-2.9	1.2	1.6	-1.4	1.0	1.6
Average weekly fortified wine intake	1.9	2.2	3.3	-1.2	1.2	1.6	-1.2	1.7	1.8
Medication: Simvastatin	1.9	2.8	11.8	-0.2	0.4	1.3	-3.4	0.7	1.6
Alcohol drinker status: Never	1.9	2.3	5.1	0.7	0.7	0.5	-2.2	1.6	2.2
Risk taking	1.9	2.8	8.0	0.3	0.0	2.8	0.4	1.9	2.2
Ever had prostate specific antigen (PSA) test	1.9	2.2	3.7	0.1	1.3	-1.9	0.3	-1.9	-1.9
Alcohol intake versus 10 years previously	1.8	2.7	7.9	2.8	-0.1	0.1	2.8	0.6	0.6
Pulse rate	1.8	3.0	11.7	-0.4	-0.5	1.2	0.4	2.1	3.4
Mouth/teeth dental problems: Dentures	1.8	3.1	4.4	-1.0	-1.6	2.1	-1.9	1.9	1.9
Wheeze or whistling in the chest in last year	1.8	3.2	7.4	0.0	-0.6	2.7	-1.1	2.4	2.1
Medication: Aspirin	1.8	2.4	7.3	-1.8	1.3	1.0	-2.7	0.4	0.9
Ever had stillbirth, spontaneous miscarriage or termination	1.8	2.0	6.5	-1.9	2.5	-1.1	-0.1	-0.2	-0.3
Ever depressed for a whole week	1.8	2.2	4.2	-2.1	0.9	-1.9	-0.1	-1.7	-1.2
Townsend deprivation index at recruitment	1.7	2.4	7.3	-2.7	0.9	1.5	0.6	1.3	1.4
Financial difficulties in last 2 years	1.7	2.3	4.9	-1.6	1.1	2.2	1.3	1.5	1.0
Hip circumference	1.7	7.3	16.3	1.7	2.1	3.8	-1.5	4.0	2.0
Worry too long after embarrassment	1.7	2.9	6.9	1.8	-1.0	-1.4	-0.8	-2.6	-1.9
Illnesses of siblings: Diabetes	1.7	2.1	8.0	0.5	-1.1	2.8	-0.1	1.4	1.0
Number of self-reported non-cancer illnesses	1.7	2.9	6.7	-0.8	1.0	2.6	-1.6	2.2	1.4
Ever taken oral contraceptive pill	1.7	1.9	3.8	-0.5	-0.5	1.9	0.2	1.9	1.9
Type 2 Diabetes (T2D) (2018)	1.6	3.1	6.4	-0.4	1.0	2.5	-1.5	2.2	2.0
Hand grip strength (left)	1.6	4.3	17.4	0.0	4.2	0.3	-2.2	-1.1	-1.5
Weight	1.6	7.9	17.7	1.3	2.0	3.9	-1.3	4.2	2.6
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.7	6.5	-0.6	0.1	1.5	1.4	2.6	2.2
Loud music exposure frequency	1.6	1.8	4.7	-0.4	0.7	2.2	-0.8	1.5	1.5
Medication: Ibuprofen	1.6	2.0	3.3	1.1	-1.8	1.7	1.1	1.7	0.5
Osteoporosis (self-reported)	1.6	1.9	7.7	-2.8	-0.3	0.3	-1.9	0.5	-0.2
Medication: Aspirin	1.6	2.1	6.9	-1.8	0.8	0.8	-2.6	0.3	0.9
Age started oral contraceptive pill	1.6	2.0	4.6	-0.1	-2.0	-1.1	-2.1	-1.4	-0.6
Schizophrenia (2018)	1.5	3.2	5.5	-2.0	-2.2	1.3	-0.6	1.7	2.3
Bipolar Disorder (2011)	1.5	1.4	6.1	0.8	-2.5	0.5	1.1	-0.4	-0.4
Smoking Status	1.5	3.6	15.6	-4.0	-2.1	0.9	0.1	0.7	0.5
Ever used hormone-replacement therapy (HRT)	1.5	1.9	4.1	-0.4	0.1	1.7	-2.0	1.5	1.3
Bilateral oophorectomy (both ovaries removed)	1.5	1.8	4.8	2.2	-0.7	1.1	0.5	1.6	1.1
Hayfever, allergic rhinitis or eczema	1.5	3.3	8.4	-0.3	0.9	-1.4	2.1	-1.9	-2.9
Worrier / anxious feelings	1.5	2.8	4.6	1.3	1.0	-1.9	-2.1	-2.1	-1.2
Hair/balding pattern: Pattern 3	1.5	2.3	5.0	2.2	-0.3	1.9	-1.2	1.7	0.9
Headache pain in last month	1.5	2.7	6.8	1.2	-0.7	2.0	0.3	2.6	1.8
Medication for pain relief, constipation, heartburn	1.5	2.5	6.5	-0.5	-0.6	-2.5	-0.1	-2.1	-1.9
Whole body fat mass	1.5	6.4	14.4	1.4	2.4	3.2	-0.9	3.8	2.3
Suffer from ‘nerves’	1.5	2.3	4.5	-1.1	-1.5	-2.1	-1.1	-2.1	-0.6
Commuting to job workplace: Walk	1.5	1.6	3.8	0.5	-0.9	-1.2	2.0	-1.2	-1.3
Worry (Nagel 2018)	1.4	2.9	7.3	0.2	-0.9	-2.3	-1.4	-2.7	-1.4
Prostate Cancer	1.4	2.0	4.2	1.0	-0.7	-2.0	1.7	-1.3	-1.4
Mean Putamen Volume	1.4	1.6	3.9	2.0	0.5	1.4	-1.5	0.1	1.0
Fasting Glucose	1.4	1.7	4.5	1.4	-0.6	-1.7	2.1	0.8	0.3
Schizophrenia (2014)	1.4	3.1	5.8	-2.3	-2.4	1.1	-0.0	1.3	2.1
Relative age voice broke	1.4	2.1	4.5	0.8	1.0	-2.1	-0.9	-1.7	-1.6
Serious illness, injury or assault to yourself	1.4	1.7	4.3	1.3	-0.2	1.4	0.8	1.3	2.1
Diabetes (self-reported)	1.4	2.2	3.6	-0.8	1.5	1.4	-1.9	1.2	1.9
Medication: Cholesterol lowering	1.4	2.2	5.6	-1.8	2.4	0.2	-1.9	-0.4	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	6.2	1.5	1.2	-0.5	2.5	-0.8	-1.4
Exposure to tobacco smoke outside home	1.4	1.9	4.2	-0.5	-0.4	1.6	-1.1	1.7	2.1
Overall health rating	1.4	3.0	7.1	0.4	1.3	2.1	-0.8	1.9	2.7
Diabetes diagnosed by doctor	1.4	2.3	3.6	-0.5	1.9	1.8	-1.7	1.3	1.5
Medication: Gliclazide	1.4	1.6	3.0	-1.1	-0.2	1.4	-0.9	1.7	1.7
Wears glasses or contact lenses	1.4	1.6	3.5	-1.9	-1.0	-1.2	1.3	-1.2	-0.8
Medication: Lisinopril	1.4	1.8	5.1	-0.8	-2.2	0.3	-2.3	-0.4	0.3
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	2.6	-1.3	1.5	1.6	-0.3	1.1	1.6
Neuroticism (Nagel 2018)	1.3	3.0	5.6	0.5	-1.5	-2.3	-0.9	-2.4	-1.9
Hearing difficulty/problems: Yes	1.3	2.0	6.9	-0.4	0.2	-1.5	0.7	-1.5	-2.6
Hand grip strength (right)	1.3	3.5	15.9	-0.2	4.0	0.3	-1.8	-1.0	-1.0
Noisy workplace	1.3	1.6	4.9	0.7	-0.8	1.6	-2.2	0.9	-0.1
Body fat percentage	1.3	5.1	11.0	0.6	2.5	2.7	-0.8	3.3	2.2
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	2.5	0.8	-1.1	-1.6	-0.8	-1.5	-1.5
Ever had bowel cancer screening	1.3	1.6	2.7	0.7	-1.2	-1.4	-0.9	-1.6	-1.4
Qualifications: nursing, teaching	1.3	2.0	3.2	-1.1	1.8	-1.4	0.7	-1.4	-1.8
Commuting to job workplace: Public transport	1.3	1.6	3.2	-1.2	0.6	-1.8	1.4	-1.3	-1.1
High cholesterol (Self-reported)	1.3	2.4	4.8	-1.5	1.3	1.3	-2.2	0.9	1.8
Commuting to job workplace: Cycle	1.3	1.5	3.1	-1.8	-1.1	-0.8	0.9	-1.1	-1.5
Verbal and Numeric Reasoning (VNR)	1.2	2.8	6.5	-1.8	2.6	-2.1	0.6	-1.4	-0.6
Neuroticism	1.2	2.8	5.1	0.8	-1.5	-2.0	-0.5	-2.2	-2.3
Medication for hormone replacement therapy	1.2	1.4	3.8	-0.6	-0.5	1.5	-0.7	1.9	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	4.7	-1.2	0.4	0.9	2.2	1.3	1.0
Trunk fat mass	1.2	5.1	10.2	1.0	2.7	2.6	-1.0	3.2	2.0
Mouth/teeth dental problems	1.2	1.9	7.0	0.3	2.6	-0.7	0.2	-1.1	-1.6
Pain all over the body in last month	1.2	1.3	2.8	0.6	0.3	1.4	-0.9	1.7	1.2
Breastfed as a baby	1.2	1.5	2.8	-1.7	1.3	1.0	0.8	0.9	1.4
Blood clot in the leg (DVT)	1.2	1.6	4.8	-0.2	-0.1	2.2	-0.5	2.0	0.5
Chronic bronchitis/emphysema (mother)	1.2	1.3	3.6	-0.2	-0.8	1.9	-0.8	1.6	0.9
Age at first live birth	1.2	2.1	6.2	-0.7	-0.1	-2.1	0.5	-2.5	-1.1
Migraine (self-reported)	1.2	1.5	3.9	0.2	0.5	2.0	-0.3	1.8	1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	3.9	1.9	0.7	-1.5	1.4	-2.0	-1.5
Blood White Count	1.1	7.9	18.7	-4.3	0.1	2.2	-2.2	2.5	3.5
Chronotype (morning person)	1.1	2.5	8.5	0.6	0.9	-0.8	-2.9	-2.0	-1.0
Supplements: Zinc	1.1	1.2	2.6	0.4	-1.1	1.0	1.6	1.6	0.2
Leg fat-free mass (left)	1.1	5.8	13.0	1.3	1.6	3.4	-1.4	3.6	1.9
Tinnitus: Yes, but not now, but have in the past	1.1	1.1	4.7	-0.8	-0.1	0.7	-2.2	0.3	0.9
Leg predicted mass (left)	1.1	5.8	13.2	1.2	1.5	3.5	-1.3	3.6	1.9
Gout (self-reported)	1.1	1.5	2.9	1.5	-1.7	0.2	0.5	-1.0	-1.5
Medication: Blood pressure	1.1	2.0	6.0	-2.4	0.8	0.8	-2.1	0.0	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.3	0.4	1.3	-1.1	-0.1	-1.5	-1.5
Eye problems/disorders: Glaucoma	1.1	1.3	4.2	-1.0	-0.1	-0.5	-1.2	-2.1	-0.8
Average weekly beer plus cider intake	1.1	1.6	5.5	1.2	-2.3	1.0	1.1	0.7	0.4
Crohns Disease (2012)	1.0	1.6	3.2	-0.5	1.8	0.6	-1.0	1.3	1.7
Number of treatments/medications taken	1.0	1.8	4.7	-1.1	0.4	2.2	0.0	1.9	1.2
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	2.9	-1.0	1.3	0.7	-0.1	1.2	1.7
Vitamin and mineral supplements	1.0	1.3	3.7	0.2	0.5	1.9	-1.9	0.5	0.3
Medication: Co-codamol	1.0	1.2	3.3	-0.1	0.6	1.8	-1.5	1.2	0.3
Diabetes (mother)	1.0	1.2	3.1	-0.0	-0.5	1.7	-0.6	1.8	0.8
Multivitamins +/- minerals	1.0	1.2	2.9	-0.1	-0.5	-1.6	1.7	-1.0	-0.8
Allergy	1.0	2.2	5.3	0.2	0.2	0.6	-2.3	1.6	2.3
Exposure to tobacco smoke at home	1.0	1.1	2.0	-0.4	0.2	1.3	1.4	1.2	1.1
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	4.9	2.2	-1.9	-0.1	1.1	0.4	0.0
Forced vital capacity (FVC), Best measure	1.0	3.8	8.4	1.7	0.1	-2.3	0.0	-2.9	-2.4
Number of children fathered	1.0	1.1	3.7	-1.0	1.9	-0.1	-0.9	1.2	-0.2
Medication: Allopurinol	1.0	1.4	2.0	1.1	-1.3	-0.7	1.4	-1.1	-1.2
Heart disease (mother)	1.0	1.3	3.8	-0.1	-0.3	-1.0	-2.0	-1.5	-0.6
Family relationship satisfaction	1.0	1.2	2.6	-1.6	-0.7	-1.2	0.9	-1.2	-0.9
Leg fat-free mass (right)	1.0	5.5	11.9	1.4	1.5	3.4	-1.6	3.5	1.7
Breast cancer (self-reported)	1.0	1.2	3.4	-1.9	1.8	0.4	0.0	0.2	-0.7
Leg predicted mass (right)	1.0	5.2	11.2	1.4	1.5	3.2	-1.6	3.4	1.6
Ever smoked	1.0	1.8	5.2	-1.8	-2.3	1.0	-0.4	0.7	0.8
Basal metabolic rate	1.0	5.3	11.9	1.7	1.1	3.3	-1.4	3.5	1.6
Intelligence (Savage-Jansen 2018)	0.9	2.9	7.2	-1.6	2.7	-1.9	1.3	-1.5	-0.3
Lung FEV1/FVC ratio	0.9	4.4	18.1	-0.2	4.3	-1.1	-1.3	-0.5	-2.3
Sensitivity / hurt feelings	0.9	1.6	4.6	0.4	0.6	-1.1	-0.9	-2.1	-1.6
Trunk fat percentage	0.9	3.5	7.0	0.3	2.6	1.9	-0.8	2.6	1.6
Hair/balding pattern: Pattern 2	0.9	1.2	3.3	0.7	0.4	-1.8	1.3	-0.9	-0.7
Hayfever/allergic rhinitis (self-reported)	0.9	1.1	3.3	-1.5	-0.1	1.8	0.4	1.1	-0.2
Fluid intelligence score	0.9	1.9	5.4	-0.9	2.3	-1.9	0.9	-1.0	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	4.8	2.1	1.5	-1.2	-0.8	-1.7	-2.2
Pulse wave reflection index	0.9	1.1	3.0	0.2	0.6	-0.6	-0.8	-1.6	-1.7
Ever highly irritable/argumentative for 2 days	0.9	1.1	5.7	-2.4	-0.3	-0.4	-0.1	0.0	-0.7
Arm fat-free mass (right)	0.9	4.7	10.0	1.3	0.4	3.2	-2.0	3.2	1.6
Arm predicted mass (right)	0.9	4.8	10.2	1.5	0.3	3.1	-2.0	3.2	1.6
Commuting to job workplace: Car/motor vehicle	0.9	1.0	1.4	0.9	0.7	1.0	-0.9	1.2	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	5.0	1.6	-0.1	-1.5	-0.5	-1.3	-2.2
Average weekly champagne plus white wine intake	0.9	1.3	2.6	0.3	0.5	-1.6	0.3	-1.4	-1.6
Financial situation satisfaction	0.9	1.2	3.3	-1.4	1.8	0.1	1.2	0.0	-0.3
Vascular/heart problems diagnosed by doctor	0.9	2.5	5.8	1.4	0.1	-2.4	1.8	-1.0	-1.7
Supplements: Calcium	0.9	1.0	1.7	-0.4	0.5	1.1	-1.2	1.0	1.3
Basal cell carcinoma (self-reported)	0.9	1.1	5.4	0.5	-0.5	0.3	-2.3	0.7	0.2
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	3.1	-0.4	0.0	1.8	-0.6	1.7	0.3
Arm predicted mass (left)	0.9	4.8	10.9	1.6	0.7	3.1	-1.5	3.3	1.7
Alzheimer’s Disease (in father)	0.8	0.8	2.3	0.5	0.0	0.9	-0.1	1.5	1.3
Ulcerative Colitis (UC)	0.8	1.6	4.3	1.5	-0.5	-2.1	0.1	-1.5	-0.7
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.9	-0.8	0.2	1.7	-0.0	1.1	0.7
Height	0.8	15.5	29.9	2.5	3.3	-4.7	1.9	-5.5	-4.6
Systolic Blood Pressure	0.8	4.0	12.0	-1.5	-1.7	-1.6	-1.0	-3.5	-1.8
Allergy or Eczema	0.8	2.1	4.4	-0.1	0.4	-1.0	2.1	-1.6	-2.1
Relative age of first facial hair	0.8	1.7	7.2	-0.4	2.7	-0.9	-0.2	-1.2	-0.6
Maternal smoking around birth	0.8	1.2	5.7	-2.4	0.6	-0.3	0.9	-0.4	0.2
Taking other prescription medications	0.8	1.3	3.0	-0.8	1.7	1.4	-0.4	1.2	0.7
Past tobacco smoking	0.8	1.4	5.7	1.4	2.4	-0.8	0.1	-0.0	-0.2
Standing height	0.8	7.9	15.3	2.0	1.8	-3.4	1.9	-3.9	-3.2
Peak expiratory flow (PEF)	0.8	1.8	7.8	0.2	2.8	1.1	-1.1	0.8	0.3
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	3.5	-0.9	1.9	-0.8	1.0	-1.1	-0.6
Glaucoma (self-reported)	0.8	1.0	4.2	-0.1	0.4	-0.8	-0.1	-2.0	-0.9
Medication: Amlodipine	0.8	1.1	3.8	-1.9	1.3	0.3	-0.4	-1.1	0.2
Emphysema/chronic bronchitis	0.8	0.9	4.3	0.1	0.2	0.8	0.6	0.5	2.1
Medication: Omeprazole	0.8	1.0	2.0	-0.2	1.2	1.4	0.1	0.9	1.3
Had major operations	0.8	0.9	4.1	0.4	2.0	0.6	0.5	0.7	0.2
Leg pain on walking	0.8	1.0	3.4	1.2	-1.9	0.3	0.5	0.7	0.3
Knee pain experienced in last month	0.8	1.2	2.6	1.1	1.1	1.1	0.2	1.6	1.1
Mineral and other dietary supplements	0.8	1.1	3.0	-0.5	-0.5	1.2	-1.7	0.9	0.9
Whole body water mass	0.8	4.4	9.3	1.6	0.6	3.0	-1.6	3.0	1.5
Arm fat-free mass (left)	0.8	4.3	10.0	1.4	0.5	2.9	-1.7	3.2	1.3
HbA1C	0.7	0.7	2.7	0.6	-0.0	-0.4	0.1	1.7	1.0
Primary Biliary Cirrhosis	0.7	1.0	1.9	-1.4	0.4	1.4	0.9	0.9	0.3
Ulcerative Colitis	0.7	1.1	2.4	1.5	1.2	-0.9	0.9	-0.3	-1.0
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	2.4	0.3	-0.3	0.9	-0.9	0.5	1.6
Qualifications: CSEs or equivalent	0.7	1.0	1.7	-0.9	0.4	1.1	-1.1	1.3	0.9
Medication: Levothyroxine sodium	0.7	1.2	3.3	-0.8	-0.1	1.2	-1.0	0.8	1.8
Forced vital capacity (FVC)	0.7	2.5	6.0	1.3	0.9	-1.4	0.2	-2.5	-2.1
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.1	0.9	-0.3	1.3	0.5	1.4	0.7
Hair/balding pattern: Pattern 4	0.7	1.6	7.7	-2.8	0.5	0.6	-0.8	-0.4	-0.6
Birth weight	0.7	1.4	5.0	0.8	2.2	0.5	1.4	0.7	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	4.2	0.3	0.9	-0.1	2.1	-0.4	-0.2
Mean time to correctly identify matches	0.7	1.3	6.5	0.4	0.8	0.3	2.5	-0.5	0.6
Alcohol intake frequency.	0.7	1.5	3.5	1.7	1.1	0.3	-0.5	1.1	1.9
Hypertension (Self-reported)	0.7	1.9	5.2	-1.0	-0.3	2.3	-1.4	0.7	1.6
Smoking status: Previous	0.7	1.1	5.7	-0.3	-2.4	0.1	0.1	-0.8	-0.1
Whole body fat-free mass	0.7	4.2	9.2	1.5	0.6	3.0	-1.5	3.0	1.4
Alcohol drinker status: Previous	0.7	0.8	2.6	1.2	0.6	-0.0	0.7	-0.1	1.6
Bipolar Disorder or Schizophrenia	0.6	1.3	4.3	-1.3	-2.1	0.6	-0.4	0.2	1.2
Alzheimer’s Disease (including proxy)	0.6	0.9	1.8	-1.1	0.2	-1.3	0.5	-1.4	-0.7
Crohns Disease (2017)	0.6	1.4	3.7	-1.3	0.2	0.7	-0.8	1.3	1.9
Breast Cancer	0.6	1.5	5.3	1.1	1.2	0.1	-2.3	0.8	0.7
Ovarian Cancer	0.6	0.9	2.1	0.3	0.8	1.4	-0.8	0.9	0.9
High blood pressure	0.6	1.7	4.7	-0.6	-0.5	2.2	-1.6	0.5	1.4
Had menopause	0.6	0.8	1.6	-0.5	-1.3	0.4	-1.0	0.7	1.1
Forced expiratory volume in 1-second (FEV1)	0.6	2.2	6.5	1.4	2.5	-0.5	-0.5	-1.4	-1.5
Pulse rate, automated reading	0.6	1.9	6.0	0.2	-0.8	0.4	1.1	1.9	2.5
Long-standing illness, disability or infirmity	0.6	1.0	2.0	-1.2	-1.0	1.0	-0.7	0.2	1.4
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.1	1.4	-1.1	0.3	0.8	0.3	1.2
Guilty feelings	0.6	1.0	3.2	1.8	-0.9	-0.5	0.3	-0.6	-1.1
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.9	0.2	-1.0	-0.2	-0.2	-1.4	-1.1
Bipolar Disorder (2018)	0.5	0.8	3.0	0.3	-0.6	-0.6	0.0	-1.7	-1.0
Reaction Time	0.5	0.9	3.7	0.7	0.6	0.7	1.9	-0.6	-0.1
Triglycerides	0.5	0.8	2.8	1.1	0.4	-0.3	-1.7	-0.3	0.9
Waist Hip Ratio (WHR)	0.5	2.1	8.1	-2.8	0.6	0.8	1.2	1.4	0.4
Frequency of depressed mood in last 2 weeks	0.5	0.6	1.4	0.1	-0.7	-1.1	1.2	-0.8	-0.2
Systolic blood pressure, automated reading	0.5	1.4	4.6	-1.2	-0.7	-0.7	-0.3	-2.1	-1.1
Sitting height	0.5	3.4	7.3	2.2	1.4	-2.0	2.7	-0.9	-1.2
Qualifications: None of the above	0.5	1.1	2.1	1.1	-1.4	0.4	1.2	0.8	0.9
Trunk fat-free mass	0.5	3.1	6.7	1.8	-0.1	2.6	-1.3	2.5	1.1
Time employed in main current job	0.5	0.6	2.4	0.3	-0.4	-0.9	1.6	0.4	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.7	-1.3	-0.5	0.6	0.6	0.8	-0.1
Trunk predicted mass	0.5	3.1	6.4	1.8	-0.0	2.5	-1.3	2.4	1.1
Birth weight of first child	0.5	1.0	3.6	-1.9	0.3	0.3	-0.2	0.1	1.4
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.9	-0.7	-1.4	-0.8	0.9	-0.4	0.2
Supplements: Vitamin C	0.5	0.6	1.0	1.0	-0.7	-1.0	0.9	-0.1	-0.5
Mood swings	0.5	0.9	2.1	0.8	-0.5	-1.4	-0.6	-1.1	-0.9
Supplements: Fish oil (including cod liver oil)	0.5	0.7	2.3	-1.5	0.4	-0.3	1.2	0.1	-0.0
Medication: Bendroflumethiazide	0.5	0.8	4.0	0.2	-2.0	0.8	0.3	0.4	0.0
Illnesses of father: High blood pressure	0.5	0.6	2.0	1.4	1.1	0.1	-0.5	-0.3	0.4
Irritability	0.5	0.8	1.8	-0.7	-1.4	-1.1	-1.0	-0.3	-0.0
Depression (Nagel 2018)	0.4	0.7	2.2	-1.5	0.1	-0.2	1.2	0.1	0.6
Blood Eosinophil Count	0.4	2.8	7.9	-2.8	2.2	0.4	1.5	0.7	1.1
Diabetes (father)	0.4	0.4	1.1	0.6	-0.2	1.1	0.8	0.6	0.4
Chronic bronchitis/emphysema (father)	0.4	0.4	1.3	-0.3	-0.8	1.1	0.5	-0.2	-0.5
Number of incorrect matches in round	0.4	0.7	1.8	1.1	-0.3	1.1	-1.4	0.2	-0.2
Alcohol usually taken with meals	0.4	0.6	1.0	-1.0	0.7	-0.5	0.6	-0.9	0.8
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	1.4	-1.2	0.1	-0.3	-0.2	-0.0	1.0
Neuroticism score	0.4	0.8	1.2	0.7	-0.9	-0.6	-1.1	-1.1	-0.8
Prospective memory result	0.4	0.5	0.9	-0.4	-0.6	-0.8	-0.6	-0.8	-1.0
Lung cancer (father)	0.4	0.4	1.3	-1.1	0.5	-0.2	0.4	-0.8	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.5	1.0	0.3	-0.1	-0.2	-0.5	-1.2
Loneliness, isolation	0.4	0.5	1.1	-0.1	-1.0	1.1	0.9	0.2	-0.3
HDL Cholesterol	0.3	0.5	1.2	1.1	0.3	0.4	-0.6	1.0	0.5
Rheumatoid Arthritis	0.3	0.5	2.2	-0.3	1.5	0.6	-0.2	0.3	-0.0
Lung FVC	0.3	1.7	5.8	-0.0	-1.1	-0.4	-0.0	-2.4	-1.8
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.8	-0.2	-0.8	0.8	0.0	0.9	-0.1
High blood pressure (mother)	0.3	0.5	1.1	0.5	-0.3	0.9	0.9	-0.2	-1.0
Hearing difficulty/problems with background noise	0.3	0.5	1.8	-1.4	0.6	0.4	-0.1	-0.0	-0.9
Depression (self-reported)	0.3	0.4	1.3	0.2	-0.3	0.7	1.1	0.6	0.3
Medication: Lansoprazole	0.3	0.4	1.5	-1.2	-0.6	0.3	0.0	-0.6	-0.2
Illnesses of mother	0.3	0.4	1.3	1.1	0.1	-0.3	0.2	0.5	0.8
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.4	-0.1	-1.2	-0.3	1.1	0.1	0.0
Pulse wave peak to peak time	0.3	0.3	1.0	-0.1	-0.3	-0.6	1.0	0.0	-0.6
Comparative height size at age 10	0.3	1.5	4.0	1.9	0.2	-0.2	2.0	-0.6	-0.8
Illnesses of father: Heart disease	0.3	0.4	1.1	0.6	-1.1	0.0	-0.6	0.8	0.3
Friendships satisfaction	0.3	0.3	1.0	0.4	0.0	0.5	1.0	-0.7	0.3
Osteoarthritis (self-reported)	0.3	0.4	1.4	-0.3	-1.2	0.6	-0.7	0.1	0.6
Hearing aid user	0.3	0.4	1.3	-0.5	-1.1	0.1	0.6	0.2	-0.5
Mother’s age at death	0.3	0.3	1.1	0.1	0.7	-0.3	1.1	-0.5	0.1
Diastolic blood pressure, automated reading	0.3	0.8	1.8	-1.4	-0.7	-0.4	0.7	-1.3	-0.6
Depressed Affect (Nagel 2018)	0.2	0.4	1.3	0.2	-1.0	-1.1	0.0	0.1	-0.5
Coronary Artery Disease (CAD)	0.2	0.3	0.6	0.3	0.6	-0.2	-0.6	-0.7	-0.4
LDL Cholesterol	0.2	0.3	0.9	0.6	0.4	-1.0	0.3	-0.1	0.3
Respiratory disease	0.2	0.4	0.8	-0.7	-0.9	0.0	0.7	0.4	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.0	-0.2	1.0	0.4	-0.2	0.2	0.6
Number of live births	0.2	0.3	1.2	-0.4	1.1	-0.2	-0.2	-0.5	-0.3
Asthma	0.2	0.5	1.6	0.4	-0.9	-0.4	1.3	0.0	0.3
Pulse wave Arterial Stiffness index	0.2	0.3	0.7	0.4	0.5	0.3	-0.9	-0.4	0.3
Tense / ‘highly strung’	0.2	0.3	0.6	-0.8	-0.1	-0.1	-0.5	-0.5	0.6
Average weekly red wine intake	0.2	0.4	1.2	-0.1	-0.6	0.5	1.1	0.5	0.3
Asthma (self-reported)	0.2	0.4	1.1	0.5	-0.8	-0.4	1.1	0.0	0.3
Illnesses of father: None of the above (group 1)	0.2	0.2	0.6	-0.2	0.5	0.2	-0.8	0.4	0.5
Myopia	0.2	0.3	0.8	0.4	0.1	-0.8	0.9	0.3	0.1
Irritable Bowel Disease (IBD)	0.1	0.2	0.8	0.3	-0.1	-0.7	-0.3	0.2	0.9
Major Depression (MDD)	0.1	0.1	0.5	-0.0	0.1	-0.2	-0.5	-0.7	0.2
Blood Red Count	0.1	0.5	1.7	-0.8	-0.3	-0.1	-0.8	1.3	0.4
Cardiovascular Disease	0.1	0.3	0.6	-0.4	0.8	0.8	-0.6	0.1	0.5
Tanning	0.1	0.9	3.0	0.2	-1.7	0.4	-1.2	0.9	0.2
Fed-up feelings	0.1	0.2	0.5	-0.2	-0.1	0.5	-0.5	0.7	0.7
Happiness	0.1	0.1	0.2	0.1	0.1	0.5	-0.3	0.5	-0.2
Health satisfaction	0.1	0.2	0.3	0.1	-0.5	0.4	0.6	0.0	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.6	-0.0	0.2	0.8	0.0	-0.1	-0.1
Miserableness	0.1	0.2	0.6	-0.2	0.3	-0.1	0.6	0.7	0.1
Lupus	0.0	0.1	0.3	-0.1	-0.1	-0.1	0.6	-0.2	0.2
Blood Platelet Count	0.0	0.5	1.2	-0.6	-0.4	1.0	-1.1	0.3	0.1
Hair Pigment	0.0	0.6	1.1	0.0	1.0	-1.0	-0.7	-1.1	-0.2

Hub : Genes

CADM1

Models

Trait associations