Hub : Genes

CADM1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Heart Left Ventricle 0.1803 0.0737 8.2e-03 0.131 NA 0.060 NA 0.118 1.9e-07 NA 4.0e-04 NA 7.9e-07
2 GTEx Stomach 0.1690 0.0610 2.8e-03 0.041 NA 0.022 NA 0.033 4.6e-03 NA 3.1e-02 NA 1.0e-02
3 GTEx Thyroid 0.5530 0.0570 0.0e+00 0.527 NA 0.503 NA 0.530 9.0e-47 NA 7.9e-44 NA 2.9e-47
4 METSIM Adipose 0.0752 0.0266 2.9e-04 0.002 0.008 0.018 0.013 0.002 1.4e-01 1.6e-02 8.3e-04 3.4e-03 1.3e-01
5 YFS Blood 0.1120 0.0207 0.0e+00 0.114 0.103 0.108 0.115 0.111 3.0e-35 1.0e-31 1.9e-33 1.1e-35 1.7e-34
6 TCGA Thyroid Carcinoma 0.1000 0.0300 8.5e-08 0.051 0.092 0.080 NA 0.054 1.1e-05 2.7e-09 3.2e-08 NA 5.5e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.5 0.8 3.0 0.3 -0.6 -0.6 0.0 -1.7 -1.0
Bipolar Disorder or Schizophrenia 0.6 1.3 4.3 -1.3 -2.1 0.6 -0.4 0.2 1.2
Depressed Affect (Nagel 2018) 0.2 0.4 1.3 0.2 -1.0 -1.1 0.0 0.1 -0.5
Depression (Nagel 2018) 0.4 0.7 2.2 -1.5 0.1 -0.2 1.2 0.1 0.6
Intelligence (Savage-Jansen 2018) 0.9 2.9 7.2 -1.6 2.7 -1.9 1.3 -1.5 -0.3
Neuroticism (Nagel 2018) 1.3 3.0 5.6 0.5 -1.5 -2.3 -0.9 -2.4 -1.9
Schizophrenia (2018) 1.5 3.2 5.5 -2.0 -2.2 1.3 -0.6 1.7 2.3
Schizophrenia vs Biploar Disorder 3.1 4.0 9.4 -1.8 -1.6 1.5 -1.0 2.4 3.1
Worry (Nagel 2018) 1.4 2.9 7.3 0.2 -0.9 -2.3 -1.4 -2.7 -1.4
Alzheimer’s Disease (in mother) 2.4 2.8 6.1 -1.6 0.1 -2.2 0.5 -2.5 -1.8
Alzheimer’s Disease (in father) 0.8 0.8 2.3 0.5 0.0 0.9 -0.1 1.5 1.3
Alzheimer’s Disease (including proxy) 0.6 0.9 1.8 -1.1 0.2 -1.3 0.5 -1.4 -0.7
Crohns Disease (2017) 0.6 1.4 3.7 -1.3 0.2 0.7 -0.8 1.3 1.9
Irritable Bowel Disease (IBD) 0.1 0.2 0.8 0.3 -0.1 -0.7 -0.3 0.2 0.9
Ulcerative Colitis (UC) 0.8 1.6 4.3 1.5 -0.5 -2.1 0.1 -1.5 -0.7
Major Depression (MDD) 0.1 0.1 0.5 -0.0 0.1 -0.2 -0.5 -0.7 0.2
Reaction Time 0.5 0.9 3.7 0.7 0.6 0.7 1.9 -0.6 -0.1
Verbal and Numeric Reasoning (VNR) 1.2 2.8 6.5 -1.8 2.6 -2.1 0.6 -1.4 -0.6
Breast Cancer 0.6 1.5 5.3 1.1 1.2 0.1 -2.3 0.8 0.7
Ovarian Cancer 0.6 0.9 2.1 0.3 0.8 1.4 -0.8 0.9 0.9
Prostate Cancer 1.4 2.0 4.2 1.0 -0.7 -2.0 1.7 -1.3 -1.4
Age at First Birth 4.3 6.3 14.9 1.7 0.3 -3.7 0.5 -3.9 -2.4
Bipolar Disorder (2011) 1.5 1.4 6.1 0.8 -2.5 0.5 1.1 -0.4 -0.4
Body Mass Index (BMI) (2010) 3.8 5.2 8.0 1.4 2.3 2.3 -1.8 2.8 2.8
Coronary Artery Disease (CAD) 0.2 0.3 0.6 0.3 0.6 -0.2 -0.6 -0.7 -0.4
Crohns Disease (2012) 1.0 1.6 3.2 -0.5 1.8 0.6 -1.0 1.3 1.7
Mean Putamen Volume 1.4 1.6 3.9 2.0 0.5 1.4 -1.5 0.1 1.0
Fasting Glucose 1.4 1.7 4.5 1.4 -0.6 -1.7 2.1 0.8 0.3
HbA1C 0.7 0.7 2.7 0.6 -0.0 -0.4 0.1 1.7 1.0
HDL Cholesterol 0.3 0.5 1.2 1.1 0.3 0.4 -0.6 1.0 0.5
LDL Cholesterol 0.2 0.3 0.9 0.6 0.4 -1.0 0.3 -0.1 0.3
Lupus 0.0 0.1 0.3 -0.1 -0.1 -0.1 0.6 -0.2 0.2
Neuroticism (2016) 2.3 3.3 7.8 0.4 -1.0 -2.2 -0.8 -2.3 -2.8
Primary Biliary Cirrhosis 0.7 1.0 1.9 -1.4 0.4 1.4 0.9 0.9 0.3
Rheumatoid Arthritis 0.3 0.5 2.2 -0.3 1.5 0.6 -0.2 0.3 -0.0
Schizophrenia (2014) 1.4 3.1 5.8 -2.3 -2.4 1.1 -0.0 1.3 2.1
Triglycerides 0.5 0.8 2.8 1.1 0.4 -0.3 -1.7 -0.3 0.9
Type 2 Diabetes (T2D) (2012) 0.8 0.9 2.9 -0.8 0.2 1.7 -0.0 1.1 0.7
Ulcerative Colitis 0.7 1.1 2.4 1.5 1.2 -0.9 0.9 -0.3 -1.0
Blood Eosinophil Count 0.4 2.8 7.9 -2.8 2.2 0.4 1.5 0.7 1.1
Blood Platelet Count 0.0 0.5 1.2 -0.6 -0.4 1.0 -1.1 0.3 0.1
Blood Red Count 0.1 0.5 1.7 -0.8 -0.3 -0.1 -0.8 1.3 0.4
Blood White Count 1.1 7.9 18.7 -4.3 0.1 2.2 -2.2 2.5 3.5
Heel T-Score 21.7 172.7 289.0 12.0 0.0 -17.0 12.8 -16.9 -12.4
BMI 4.1 23.8 56.1 0.4 2.3 6.8 -3.1 7.5 5.1
Height 0.8 15.5 29.9 2.5 3.3 -4.7 1.9 -5.5 -4.6
Waist Hip Ratio (WHR) 0.5 2.1 8.1 -2.8 0.6 0.8 1.2 1.4 0.4
Systolic Blood Pressure 0.8 4.0 12.0 -1.5 -1.7 -1.6 -1.0 -3.5 -1.8
Smoking Status 1.5 3.6 15.6 -4.0 -2.1 0.9 0.1 0.7 0.5
Allergy or Eczema 0.8 2.1 4.4 -0.1 0.4 -1.0 2.1 -1.6 -2.1
Cardiovascular Disease 0.1 0.3 0.6 -0.4 0.8 0.8 -0.6 0.1 0.5
Hypothyroidism (self reported) 2.7 6.1 16.2 0.9 -0.4 4.0 -1.5 2.6 3.2
Respiratory disease 0.2 0.4 0.8 -0.7 -0.9 0.0 0.7 0.4 0.6
Type 2 Diabetes (T2D) (2018) 1.6 3.1 6.4 -0.4 1.0 2.5 -1.5 2.2 2.0
Lung FEV1/FVC ratio 0.9 4.4 18.1 -0.2 4.3 -1.1 -1.3 -0.5 -2.3
Lung FVC 0.3 1.7 5.8 -0.0 -1.1 -0.4 -0.0 -2.4 -1.8
Neuroticism 1.2 2.8 5.1 0.8 -1.5 -2.0 -0.5 -2.2 -2.3
Chronotype (morning person) 1.1 2.5 8.5 0.6 0.9 -0.8 -2.9 -2.0 -1.0
Hair Pigment 0.0 0.6 1.1 0.0 1.0 -1.0 -0.7 -1.1 -0.2
Tanning 0.1 0.9 3.0 0.2 -1.7 0.4 -1.2 0.9 0.2
Hand grip strength (left) 1.6 4.3 17.4 0.0 4.2 0.3 -2.2 -1.1 -1.5
Number of treatments/medications taken 1.0 1.8 4.7 -1.1 0.4 2.2 0.0 1.9 1.2
Average weekly spirits intake 3.3 4.1 11.5 -3.4 -2.0 1.6 -0.4 1.7 1.9
Sensitivity / hurt feelings 0.9 1.6 4.6 0.4 0.6 -1.1 -0.9 -2.1 -1.6
Frequency of depressed mood in last 2 weeks 0.5 0.6 1.4 0.1 -0.7 -1.1 1.2 -0.8 -0.2
Hearing difficulty/problems: Yes 1.3 2.0 6.9 -0.4 0.2 -1.5 0.7 -1.5 -2.6
Relative age of first facial hair 0.8 1.7 7.2 -0.4 2.7 -0.9 -0.2 -1.2 -0.6
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 2.9 -1.0 1.3 0.7 -0.1 1.2 1.7
Ever used hormone-replacement therapy (HRT) 1.5 1.9 4.1 -0.4 0.1 1.7 -2.0 1.5 1.3
Ever had hysterectomy (womb removed) 3.3 3.7 9.0 0.7 -0.8 2.5 -1.3 2.1 3.0
Systolic blood pressure, automated reading 0.5 1.4 4.6 -1.2 -0.7 -0.7 -0.3 -2.1 -1.1
Eye problems/disorders: Diabetes related eye disease 0.7 0.7 2.4 0.3 -0.3 0.9 -0.9 0.5 1.6
Angina 8.1 10.7 21.0 -0.1 1.5 4.6 -3.4 3.3 4.3
Medication for hormone replacement therapy 1.2 1.4 3.8 -0.6 -0.5 1.5 -0.7 1.9 1.0
Vitamin and mineral supplements 1.0 1.3 3.7 0.2 0.5 1.9 -1.9 0.5 0.3
Supplements: Zinc 1.1 1.2 2.6 0.4 -1.1 1.0 1.6 1.6 0.2
Medication: Co-codamol 1.0 1.2 3.3 -0.1 0.6 1.8 -1.5 1.2 0.3
Medication: Metformin 3.5 4.9 11.1 0.4 0.3 3.3 -2.0 2.6 2.7
Diabetes (father) 0.4 0.4 1.1 0.6 -0.2 1.1 0.8 0.6 0.4
Diabetes (mother) 1.0 1.2 3.1 -0.0 -0.5 1.7 -0.6 1.8 0.8
Severe depression (siblings) 2.0 2.2 5.2 0.1 -0.5 1.5 1.8 1.6 2.3
Pack years adult smoking proportion 2.3 3.5 8.0 -2.8 1.6 1.8 -1.6 1.4 1.7
Impedance of leg (right) 2.8 13.3 29.1 0.0 0.2 -5.2 3.0 -5.4 -3.8
Leg fat-free mass (left) 1.1 5.8 13.0 1.3 1.6 3.4 -1.4 3.6 1.9
Trunk fat percentage 0.9 3.5 7.0 0.3 2.6 1.9 -0.8 2.6 1.6
Hand grip strength (right) 1.3 3.5 15.9 -0.2 4.0 0.3 -1.8 -1.0 -1.0
Townsend deprivation index at recruitment 1.7 2.4 7.3 -2.7 0.9 1.5 0.6 1.3 1.4
Current tobacco smoking 3.4 5.5 13.6 -3.7 0.3 2.6 -0.7 2.7 2.2
Average weekly fortified wine intake 1.9 2.2 3.3 -1.2 1.2 1.6 -1.2 1.7 1.8
Maternal smoking around birth 0.8 1.2 5.7 -2.4 0.6 -0.3 0.9 -0.4 0.2
Fed-up feelings 0.1 0.2 0.5 -0.2 -0.1 0.5 -0.5 0.7 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.6 4.7 -1.2 0.4 0.9 2.2 1.3 1.0
Relative age voice broke 1.4 2.1 4.5 0.8 1.0 -2.1 -0.9 -1.7 -1.6
Taking other prescription medications 0.8 1.3 3.0 -0.8 1.7 1.4 -0.4 1.2 0.7
Age when periods started (menarche) 2.6 6.3 13.6 -0.4 0.7 -3.7 2.7 -3.3 -2.4
Bilateral oophorectomy (both ovaries removed) 1.5 1.8 4.8 2.2 -0.7 1.1 0.5 1.6 1.1
Heel bone mineral density (BMD) T-score, automated (left) 12.3 27.9 50.1 4.4 0.9 -6.5 5.3 -7.1 -5.2
Tinnitus: Yes, but not now, but have in the past 1.1 1.1 4.7 -0.8 -0.1 0.7 -2.2 0.3 0.9
Qualifications: CSEs or equivalent 0.7 1.0 1.7 -0.9 0.4 1.1 -1.1 1.3 0.9
Serious illness, injury or assault to yourself 1.4 1.7 4.3 1.3 -0.2 1.4 0.8 1.3 2.1
High blood pressure 0.6 1.7 4.7 -0.6 -0.5 2.2 -1.6 0.5 1.4
Hayfever, allergic rhinitis or eczema 1.5 3.3 8.4 -0.3 0.9 -1.4 2.1 -1.9 -2.9
Multivitamins +/- minerals 1.0 1.2 2.9 -0.1 -0.5 -1.6 1.7 -1.0 -0.8
Stomach or abdominal pain in last month 4.1 5.1 12.7 -0.2 -0.9 3.6 -0.0 2.6 3.2
Supplements: Glucosamine 4.9 6.3 13.8 2.0 -1.1 -3.7 1.7 -3.0 -2.7
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 0.8 -0.2 -0.8 0.8 0.0 0.9 -0.1
Medication: Atenolol 2.5 3.2 8.1 -0.1 -0.7 2.8 -1.9 1.8 1.9
Medication: Levothyroxine sodium 0.7 1.2 3.3 -0.8 -0.1 1.2 -1.0 0.8 1.8
Sitting height 0.5 3.4 7.3 2.2 1.4 -2.0 2.7 -0.9 -1.2
Chronic bronchitis/emphysema (father) 0.4 0.4 1.3 -0.3 -0.8 1.1 0.5 -0.2 -0.5
High blood pressure (mother) 0.3 0.5 1.1 0.5 -0.3 0.9 0.9 -0.2 -1.0
Body mass index (BMI) 3.7 15.9 38.8 0.6 1.2 5.7 -2.3 6.2 4.2
Impedance of leg (left) 2.9 14.2 32.2 0.4 0.3 -5.4 2.8 -5.7 -4.0
Leg predicted mass (left) 1.1 5.8 13.2 1.2 1.5 3.5 -1.3 3.6 1.9
Trunk fat mass 1.2 5.1 10.2 1.0 2.7 2.6 -1.0 3.2 2.0
Waist circumference 3.1 11.3 26.8 -0.4 2.3 4.7 -1.4 5.2 3.4
Number of incorrect matches in round 0.4 0.7 1.8 1.1 -0.3 1.1 -1.4 0.2 -0.2
Past tobacco smoking 0.8 1.4 5.7 1.4 2.4 -0.8 0.1 -0.0 -0.2
Alcohol usually taken with meals 0.4 0.6 1.0 -1.0 0.7 -0.5 0.6 -0.9 0.8
Nervous feelings 2.2 4.1 9.5 1.6 -0.5 -2.4 -0.4 -3.1 -2.5
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 1.0 -0.2 1.0 0.4 -0.2 0.2 0.6
Hearing difficulty/problems with background noise 0.3 0.5 1.8 -1.4 0.6 0.4 -0.1 -0.0 -0.9
Hair/balding pattern: Pattern 2 0.9 1.2 3.3 0.7 0.4 -1.8 1.3 -0.9 -0.7
Had menopause 0.6 0.8 1.6 -0.5 -1.3 0.4 -1.0 0.7 1.1
Had other major operations 2.2 2.7 5.1 -2.3 -0.3 2.2 -0.5 2.1 1.4
Forced vital capacity (FVC) 0.7 2.5 6.0 1.3 0.9 -1.4 0.2 -2.5 -2.1
Heel bone mineral density (BMD) T-score, automated (right) 12.2 27.9 46.5 4.3 1.7 -6.8 5.0 -6.8 -5.4
Ever unenthusiastic/disinterested for a whole week 0.4 0.4 1.4 -1.2 0.1 -0.3 -0.2 -0.0 1.0
Qualifications: None of the above 0.5 1.1 2.1 1.1 -1.4 0.4 1.2 0.8 0.9
Financial difficulties in last 2 years 1.7 2.3 4.9 -1.6 1.1 2.2 1.3 1.5 1.0
Mouth/teeth dental problems 1.2 1.9 7.0 0.3 2.6 -0.7 0.2 -1.1 -1.6
Heart attack 4.7 6.0 9.2 -2.2 2.1 3.0 -2.8 2.4 1.9
Allergy 1.0 2.2 5.3 0.2 0.2 0.6 -2.3 1.6 2.3
Pain all over the body in last month 1.2 1.3 2.8 0.6 0.3 1.4 -0.9 1.7 1.2
Diabetes (self-reported) 1.4 2.2 3.6 -0.8 1.5 1.4 -1.9 1.2 1.9
Hayfever/allergic rhinitis (self-reported) 0.9 1.1 3.3 -1.5 -0.1 1.8 0.4 1.1 -0.2
Medication: Ramipril 2.7 3.4 9.0 -1.6 -0.7 2.2 -3.0 1.2 1.5
Medication: Simvastatin 1.9 2.8 11.8 -0.2 0.4 1.3 -3.4 0.7 1.6
Fluid intelligence score 0.9 1.9 5.4 -0.9 2.3 -1.9 0.9 -1.0 0.2
Illnesses of siblings 4.5 6.3 19.4 -1.5 -0.4 -4.4 0.8 -3.3 -2.1
Neuroticism score 0.4 0.8 1.2 0.7 -0.9 -0.6 -1.1 -1.1 -0.8
Weight 1.6 7.9 17.7 1.3 2.0 3.9 -1.3 4.2 2.6
Impedance of arm (right) 3.0 14.0 29.2 -0.3 1.7 -5.2 3.1 -5.4 -3.9
Arm fat percentage (right) 2.2 8.7 19.1 1.1 2.4 3.9 -1.4 4.4 3.0
Trunk fat-free mass 0.5 3.1 6.7 1.8 -0.1 2.6 -1.3 2.5 1.1
Hip circumference 1.7 7.3 16.3 1.7 2.1 3.8 -1.5 4.0 2.0
Time employed in main current job 0.5 0.6 2.4 0.3 -0.4 -0.9 1.6 0.4 0.4
Alcohol intake versus 10 years previously 1.8 2.7 7.9 2.8 -0.1 0.1 2.8 0.6 0.6
Father’s age at death 2.2 3.0 8.6 1.7 -1.3 -1.3 2.9 -0.8 -1.5
Worrier / anxious feelings 1.5 2.8 4.6 1.3 1.0 -1.9 -2.1 -2.1 -1.2
Frequency of tiredness / lethargy in last 2 weeks 1.6 2.7 6.5 -0.6 0.1 1.5 1.4 2.6 2.2
Falls in the last year 3.4 4.6 10.6 -1.2 -1.0 2.1 1.1 3.0 3.2
Hair/balding pattern: Pattern 3 1.5 2.3 5.0 2.2 -0.3 1.9 -1.2 1.7 0.9
Number of live births 0.2 0.3 1.2 -0.4 1.1 -0.2 -0.2 -0.5 -0.3
Forced expiratory volume in 1-second (FEV1) 0.6 2.2 6.5 1.4 2.5 -0.5 -0.5 -1.4 -1.5
Pulse rate 1.8 3.0 11.7 -0.4 -0.5 1.2 0.4 2.1 3.4
Happiness 0.1 0.1 0.2 0.1 0.1 0.5 -0.3 0.5 -0.2
Noisy workplace 1.3 1.6 4.9 0.7 -0.8 1.6 -2.2 0.9 -0.1
Qualifications: A levels/AS levels or equivalent 2.4 5.4 13.4 -1.3 2.1 -2.9 0.6 -3.7 -2.0
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 1.7 -1.3 -0.5 0.6 0.6 0.8 -0.1
Mouth/teeth dental problems: Dentures 1.8 3.1 4.4 -1.0 -1.6 2.1 -1.9 1.9 1.9
Asthma 0.2 0.5 1.6 0.4 -0.9 -0.4 1.3 0.0 0.3
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 2.1 0.9 -0.3 1.3 0.5 1.4 0.7
Medication: Cholesterol lowering 1.4 2.2 5.6 -1.8 2.4 0.2 -1.9 -0.4 -0.4
Depression (self-reported) 0.3 0.4 1.3 0.2 -0.3 0.7 1.1 0.6 0.3
Medication: Lansoprazole 0.3 0.4 1.5 -1.2 -0.6 0.3 0.0 -0.6 -0.2
Prospective memory result 0.4 0.5 0.9 -0.4 -0.6 -0.8 -0.6 -0.8 -1.0
Lung cancer (father) 0.4 0.4 1.3 -1.1 0.5 -0.2 0.4 -0.8 -0.2
Illnesses of mother 0.3 0.4 1.3 1.1 0.1 -0.3 0.2 0.5 0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.8 4.8 2.1 1.5 -1.2 -0.8 -1.7 -2.2
Pulse wave Arterial Stiffness index 0.2 0.3 0.7 0.4 0.5 0.3 -0.9 -0.4 0.3
Impedance of arm (left) 2.6 12.0 24.2 -0.6 1.6 -4.9 2.9 -4.9 -3.6
Arm fat mass (right) 2.4 10.0 23.6 1.5 2.1 4.2 -1.4 4.9 3.1
Trunk predicted mass 0.5 3.1 6.4 1.8 -0.0 2.5 -1.3 2.4 1.1
Standing height 0.8 7.9 15.3 2.0 1.8 -3.4 1.9 -3.9 -3.2
Length of working week for main job 2.4 2.7 8.8 -1.4 1.3 0.3 -3.0 1.5 1.0
Exposure to tobacco smoke at home 1.0 1.1 2.0 -0.4 0.2 1.3 1.4 1.2 1.1
Breastfed as a baby 1.2 1.5 2.8 -1.7 1.3 1.0 0.8 0.9 1.4
Tense / ‘highly strung’ 0.2 0.3 0.6 -0.8 -0.1 -0.1 -0.5 -0.5 0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 1.4 2.1 6.2 1.5 1.2 -0.5 2.5 -0.8 -1.4
Hair/balding pattern: Pattern 4 0.7 1.6 7.7 -2.8 0.5 0.6 -0.8 -0.4 -0.6
Birth weight of first child 0.5 1.0 3.6 -1.9 0.3 0.3 -0.2 0.1 1.4
Peak expiratory flow (PEF) 0.8 1.8 7.8 0.2 2.8 1.1 -1.1 0.8 0.3
Pulse wave reflection index 0.9 1.1 3.0 0.2 0.6 -0.6 -0.8 -1.6 -1.7
Ever highly irritable/argumentative for 2 days 0.9 1.1 5.7 -2.4 -0.3 -0.4 -0.1 0.0 -0.7
Loud music exposure frequency 1.6 1.8 4.7 -0.4 0.7 2.2 -0.8 1.5 1.5
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 3.5 -0.9 1.9 -0.8 1.0 -1.1 -0.6
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 1.9 -0.7 -1.4 -0.8 0.9 -0.4 0.2
Blood clot in the leg (DVT) 1.2 1.6 4.8 -0.2 -0.1 2.2 -0.5 2.0 0.5
Medication: Paracetamol 2.4 4.0 9.6 0.9 -0.3 3.1 2.0 2.8 1.2
Headache pain in last month 1.5 2.7 6.8 1.2 -0.7 2.0 0.3 2.6 1.8
Medication for cholesterol, blood pressure or diabetes 1.0 1.6 4.9 2.2 -1.9 -0.1 1.1 0.4 0.0
Glaucoma (self-reported) 0.8 1.0 4.2 -0.1 0.4 -0.8 -0.1 -2.0 -0.9
Gout (self-reported) 1.1 1.5 2.9 1.5 -1.7 0.2 0.5 -1.0 -1.5
Hypothyroidism/myxoedema (self-reported) 2.1 4.1 9.1 0.1 -0.7 3.0 -1.6 1.9 3.0
Medication: Amlodipine 0.8 1.1 3.8 -1.9 1.3 0.3 -0.4 -1.1 0.2
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.4 -0.1 -1.2 -0.3 1.1 0.1 0.0
Birth weight 0.7 1.4 5.0 0.8 2.2 0.5 1.4 0.7 0.4
Chronic bronchitis/emphysema (mother) 1.2 1.3 3.6 -0.2 -0.8 1.9 -0.8 1.6 0.9
High blood pressure (siblings) 2.9 4.2 13.4 0.9 0.2 3.7 -0.6 2.9 1.5
Forced vital capacity (FVC), Best measure 1.0 3.8 8.4 1.7 0.1 -2.3 0.0 -2.9 -2.4
Body fat percentage 1.3 5.1 11.0 0.6 2.5 2.7 -0.8 3.3 2.2
Leg fat percentage (right) 2.0 7.4 17.6 0.4 1.9 3.6 -0.9 4.2 3.1
Arm fat-free mass (right) 0.9 4.7 10.0 1.3 0.4 3.2 -2.0 3.2 1.6
Exposure to tobacco smoke outside home 1.4 1.9 4.2 -0.5 -0.4 1.6 -1.1 1.7 2.1
Comparative body size at age 10 2.9 8.1 20.4 1.7 0.4 4.5 -3.6 2.7 2.2
Number of full brothers 2.1 2.7 8.1 0.0 -0.6 2.5 0.3 2.9 1.2
Worry too long after embarrassment 1.7 2.9 6.9 1.8 -1.0 -1.4 -0.8 -2.6 -1.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 4.2 0.3 0.9 -0.1 2.1 -0.4 -0.2
Wheeze or whistling in the chest in last year 1.8 3.2 7.4 0.0 -0.6 2.7 -1.1 2.4 2.1
Number of children fathered 1.0 1.1 3.7 -1.0 1.9 -0.1 -0.9 1.2 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.5 1.0 0.3 -0.1 -0.2 -0.5 -1.2
Age at first live birth 1.2 2.1 6.2 -0.7 -0.1 -2.1 0.5 -2.5 -1.1
Pulse wave peak to peak time 0.3 0.3 1.0 -0.1 -0.3 -0.6 1.0 0.0 -0.6
Health satisfaction 0.1 0.2 0.3 0.1 -0.5 0.4 0.6 0.0 0.5
Shortness of breath walking on level ground 4.6 5.5 11.1 -1.9 0.7 3.3 0.0 2.8 3.2
Qualifications: College or University degree 2.8 8.9 17.9 -0.7 1.9 -4.2 1.2 -4.0 -3.7
Eye problems/disorders: None of the above 2.5 2.9 6.5 -0.4 2.6 -1.4 2.1 -0.7 -1.9
Mouth/teeth dental problems: Loose teeth 2.4 2.9 4.8 -1.7 0.6 1.8 -1.7 2.2 1.8
Emphysema/chronic bronchitis 0.8 0.9 4.3 0.1 0.2 0.8 0.6 0.5 2.1
Medication for pain relief, constipation, heartburn 1.5 2.5 6.5 -0.5 -0.6 -2.5 -0.1 -2.1 -1.9
Neck or shoulder pain in last month 2.1 3.0 5.8 1.3 0.7 2.2 -0.5 2.2 2.4
Medication: Blood pressure 1.1 2.0 6.0 -2.4 0.8 0.8 -2.1 0.0 0.5
Angina (self-reported) 8.5 11.1 22.2 -0.1 1.4 4.7 -3.3 3.5 4.5
Migraine (self-reported) 1.2 1.5 3.9 0.2 0.5 2.0 -0.3 1.8 1.2
Medication: Ibuprofen 1.6 2.0 3.3 1.1 -1.8 1.7 1.1 1.7 0.5
Medication: Allopurinol 1.0 1.4 2.0 1.1 -1.3 -0.7 1.4 -1.1 -1.2
Medication: Omeprazole 0.8 1.0 2.0 -0.2 1.2 1.4 0.1 0.9 1.3
Medication: Seretide 50 evohaler 2.1 2.5 6.2 -0.1 -0.2 1.9 0.6 2.5 2.1
Mean time to correctly identify matches 0.7 1.3 6.5 0.4 0.8 0.3 2.5 -0.5 0.6
Heart disease (mother) 1.0 1.3 3.8 -0.1 -0.3 -1.0 -2.0 -1.5 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.6 -0.0 0.2 0.8 0.0 -0.1 -0.1
Whole body fat mass 1.5 6.4 14.4 1.4 2.4 3.2 -0.9 3.8 2.3
Leg fat mass (right) 2.4 9.1 21.1 1.1 2.0 4.2 -1.1 4.6 3.2
Arm predicted mass (right) 0.9 4.8 10.2 1.5 0.3 3.1 -2.0 3.2 1.6
Pulse rate, automated reading 0.6 1.9 6.0 0.2 -0.8 0.4 1.1 1.9 2.5
Alcohol intake frequency. 0.7 1.5 3.5 1.7 1.1 0.3 -0.5 1.1 1.9
Comparative height size at age 10 0.3 1.5 4.0 1.9 0.2 -0.2 2.0 -0.6 -0.8
Number of full sisters 5.8 7.0 15.0 -1.0 1.2 3.6 0.3 3.9 3.4
Suffer from ‘nerves’ 1.5 2.3 4.5 -1.1 -1.5 -2.1 -1.1 -2.1 -0.6
Overall health rating 1.4 3.0 7.1 0.4 1.3 2.1 -0.8 1.9 2.7
Chest pain or discomfort 8.5 12.2 27.4 -0.2 -2.0 4.7 -2.0 4.0 5.2
Had major operations 0.8 0.9 4.1 0.4 2.0 0.6 0.5 0.7 0.2
Age at last live birth 3.3 4.7 13.9 -0.5 0.7 -3.1 -0.1 -3.7 -2.0
Family relationship satisfaction 1.0 1.2 2.6 -1.6 -0.7 -1.2 0.9 -1.2 -0.9
Leg pain on walking 0.8 1.0 3.4 1.2 -1.9 0.3 0.5 0.7 0.3
Qualifications: NVQ or HND or HNC or equivalent 3.3 4.0 10.0 1.1 -0.5 2.8 -3.2 1.9 1.1
Commuting to job workplace: Car/motor vehicle 0.9 1.0 1.4 0.9 0.7 1.0 -0.9 1.2 1.2
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 2.5 0.8 -1.1 -1.6 -0.8 -1.5 -1.5
Medication: Aspirin 1.8 2.4 7.3 -1.8 1.3 1.0 -2.7 0.4 0.9
Supplements: Vitamin C 0.5 0.6 1.0 1.0 -0.7 -1.0 0.9 -0.1 -0.5
Knee pain experienced in last month 0.8 1.2 2.6 1.1 1.1 1.1 0.2 1.6 1.1
Hypertension (Self-reported) 0.7 1.9 5.2 -1.0 -0.3 2.3 -1.4 0.7 1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 2.3 0.4 1.3 -1.1 -0.1 -1.5 -1.5
Illnesses of father: Heart disease 0.3 0.4 1.1 0.6 -1.1 0.0 -0.6 0.8 0.3
Illnesses of siblings: Diabetes 1.7 2.1 8.0 0.5 -1.1 2.8 -0.1 1.4 1.0
Smoking status: Previous 0.7 1.1 5.7 -0.3 -2.4 0.1 0.1 -0.8 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 1.2 2.5 3.9 1.9 0.7 -1.5 1.4 -2.0 -1.5
Whole body fat-free mass 0.7 4.2 9.2 1.5 0.6 3.0 -1.5 3.0 1.4
Leg fat-free mass (right) 1.0 5.5 11.9 1.4 1.5 3.4 -1.6 3.5 1.7
Arm fat percentage (left) 2.4 9.7 22.3 0.8 2.6 4.0 -1.4 4.7 3.2
Average weekly red wine intake 0.2 0.4 1.2 -0.1 -0.6 0.5 1.1 0.5 0.3
Handedness (chirality/laterality): Left-handed 3.4 4.1 8.8 0.3 0.8 -2.5 -1.3 -3.0 -2.7
Mood swings 0.5 0.9 2.1 0.8 -0.5 -1.4 -0.6 -1.1 -0.9
Loneliness, isolation 0.4 0.5 1.1 -0.1 -1.0 1.1 0.9 0.2 -0.3
Long-standing illness, disability or infirmity 0.6 1.0 2.0 -1.2 -1.0 1.0 -0.7 0.2 1.4
Ever had bowel cancer screening 1.3 1.6 2.7 0.7 -1.2 -1.4 -0.9 -1.6 -1.4
Diabetes diagnosed by doctor 1.4 2.3 3.6 -0.5 1.9 1.8 -1.7 1.3 1.5
Ever had stillbirth, spontaneous miscarriage or termination 1.8 2.0 6.5 -1.9 2.5 -1.1 -0.1 -0.2 -0.3
Friendships satisfaction 0.3 0.3 1.0 0.4 0.0 0.5 1.0 -0.7 0.3
Qualifications: nursing, teaching 1.3 2.0 3.2 -1.1 1.8 -1.4 0.7 -1.4 -1.8
Commuting to job workplace: Walk 1.5 1.6 3.8 0.5 -0.9 -1.2 2.0 -1.2 -1.3
Eye problems/disorders: Cataract 2.0 2.3 4.8 1.4 -2.2 1.2 -1.9 0.6 1.4
Mouth/teeth dental problems: Mouth ulcers 0.6 0.9 2.1 1.4 -1.1 0.3 0.8 0.3 1.2
Medication for cholesterol 5.4 8.2 16.2 1.1 1.3 -4.0 2.8 -3.3 -3.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.0 3.5 8.0 -1.0 -0.9 2.0 -0.7 2.5 2.8
Back pain experienced in last month 2.2 3.1 6.8 0.7 -1.7 2.2 -0.8 2.6 1.7
Mineral and other dietary supplements 0.8 1.1 3.0 -0.5 -0.5 1.2 -1.7 0.9 0.9
Breast cancer (self-reported) 1.0 1.2 3.4 -1.9 1.8 0.4 0.0 0.2 -0.7
Asthma (self-reported) 0.2 0.4 1.1 0.5 -0.8 -0.4 1.1 0.0 0.3
Osteoporosis (self-reported) 1.6 1.9 7.7 -2.8 -0.3 0.3 -1.9 0.5 -0.2
Osteoarthritis (self-reported) 0.3 0.4 1.4 -0.3 -1.2 0.6 -0.7 0.1 0.6
Medication: Aspirin 1.6 2.1 6.9 -1.8 0.8 0.8 -2.6 0.3 0.9
Medication: Gliclazide 1.4 1.6 3.0 -1.1 -0.2 1.4 -0.9 1.7 1.7
Illnesses of father: None of the above (group 1) 0.2 0.2 0.6 -0.2 0.5 0.2 -0.8 0.4 0.5
Smoking status: Current 2.6 4.2 11.0 -3.3 0.4 2.2 -0.4 2.4 1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.9 5.0 1.6 -0.1 -1.5 -0.5 -1.3 -2.2
Whole body water mass 0.8 4.4 9.3 1.6 0.6 3.0 -1.6 3.0 1.5
Leg predicted mass (right) 1.0 5.2 11.2 1.4 1.5 3.2 -1.6 3.4 1.6
Arm fat mass (left) 2.6 10.7 25.8 1.1 2.3 4.4 -1.6 5.1 3.2
Number of self-reported non-cancer illnesses 1.7 2.9 6.7 -0.8 1.0 2.6 -1.6 2.2 1.4
Average weekly champagne plus white wine intake 0.9 1.3 2.6 0.3 0.5 -1.6 0.3 -1.4 -1.6
Miserableness 0.1 0.2 0.6 -0.2 0.3 -0.1 0.6 0.7 0.1
Guilty feelings 0.6 1.0 3.2 1.8 -0.9 -0.5 0.3 -0.6 -1.1
Wears glasses or contact lenses 1.4 1.6 3.5 -1.9 -1.0 -1.2 1.3 -1.2 -0.8
Ever taken oral contraceptive pill 1.7 1.9 3.8 -0.5 -0.5 1.9 0.2 1.9 1.9
Hearing aid user 0.3 0.4 1.3 -0.5 -1.1 0.1 0.6 0.2 -0.5
Mother’s age at death 0.3 0.3 1.1 0.1 0.7 -0.3 1.1 -0.5 0.1
Financial situation satisfaction 0.9 1.2 3.3 -1.4 1.8 0.1 1.2 0.0 -0.3
Tinnitus: Yes, now most or all of the time 0.6 0.7 1.9 0.2 -1.0 -0.2 -0.2 -1.4 -1.1
Commuting to job workplace: Public transport 1.3 1.6 3.2 -1.2 0.6 -1.8 1.4 -1.3 -1.1
Eye problems/disorders: Glaucoma 1.1 1.3 4.2 -1.0 -0.1 -0.5 -1.2 -2.1 -0.8
Medication: Blood pressure 2.0 3.9 11.4 -1.2 -0.5 3.4 -1.9 1.7 1.9
Pain type(s) experienced in last month: Hip pain 3.2 4.1 10.1 0.0 -0.7 3.2 -0.3 2.2 3.0
Supplements: Fish oil (including cod liver oil) 0.5 0.7 2.3 -1.5 0.4 -0.3 1.2 0.1 -0.0
High cholesterol (Self-reported) 1.3 2.4 4.8 -1.5 1.3 1.3 -2.2 0.9 1.8
Medication: Bendroflumethiazide 0.5 0.8 4.0 0.2 -2.0 0.8 0.3 0.4 0.0
Medication: Paracetamol 2.6 4.1 9.5 0.6 -1.5 3.1 2.1 2.5 1.2
Medication: Lisinopril 1.4 1.8 5.1 -0.8 -2.2 0.3 -2.3 -0.4 0.3
Medication: Atorvastatin 3.2 3.9 12.0 -2.8 3.5 0.6 -1.9 -0.1 0.1
Illnesses of father: High blood pressure 0.5 0.6 2.0 1.4 1.1 0.1 -0.5 -0.3 0.4
Alcohol drinker status: Never 1.9 2.3 5.1 0.7 0.7 0.5 -2.2 1.6 2.2
Ever smoked 1.0 1.8 5.2 -1.8 -2.3 1.0 -0.4 0.7 0.8
Basal metabolic rate 1.0 5.3 11.9 1.7 1.1 3.3 -1.4 3.5 1.6
Leg fat percentage (left) 2.2 7.9 17.9 0.7 1.9 3.8 -1.2 4.2 3.1
Arm fat-free mass (left) 0.8 4.3 10.0 1.4 0.5 2.9 -1.7 3.2 1.3
Number of operations (self-reported) 3.9 5.7 13.4 -1.7 0.6 3.7 -0.7 3.3 2.5
Average weekly beer plus cider intake 1.1 1.6 5.5 1.2 -2.3 1.0 1.1 0.7 0.4
Irritability 0.5 0.8 1.8 -0.7 -1.4 -1.1 -1.0 -0.3 -0.0
Risk taking 1.9 2.8 8.0 0.3 0.0 2.8 0.4 1.9 2.2
Ever had prostate specific antigen (PSA) test 1.9 2.2 3.7 0.1 1.3 -1.9 0.3 -1.9 -1.9
Fractured/broken bones in last 5 years 2.8 3.6 7.9 -0.8 -0.1 2.1 -1.3 2.8 2.6
Age started oral contraceptive pill 1.6 2.0 4.6 -0.1 -2.0 -1.1 -2.1 -1.4 -0.6
Diastolic blood pressure, automated reading 0.3 0.8 1.8 -1.4 -0.7 -0.4 0.7 -1.3 -0.6
Ever depressed for a whole week 1.8 2.2 4.2 -2.1 0.9 -1.9 -0.1 -1.7 -1.2
Unable to work because of sickness or disability 5.3 6.9 16.2 0.4 1.3 3.2 0.6 4.0 3.5
Commuting to job workplace: Cycle 1.3 1.5 3.1 -1.8 -1.1 -0.8 0.9 -1.1 -1.5
Myopia 0.2 0.3 0.8 0.4 0.1 -0.8 0.9 0.3 0.1
Vascular/heart problems diagnosed by doctor 0.9 2.5 5.8 1.4 0.1 -2.4 1.8 -1.0 -1.7
Cholesterol lowering medication 3.7 5.5 15.8 -1.3 -0.1 2.4 -4.0 1.6 2.7
Medication: Omeprazole (e.g. Zanprol) 1.4 1.7 2.6 -1.3 1.5 1.6 -0.3 1.1 1.6
Pain experienced in last month 2.4 4.0 10.4 -0.9 -0.2 -2.6 0.7 -3.2 -2.3
Supplements: Calcium 0.9 1.0 1.7 -0.4 0.5 1.1 -1.2 1.0 1.3
Basal cell carcinoma (self-reported) 0.9 1.1 5.4 0.5 -0.5 0.3 -2.3 0.7 0.2
Heart attack/myocardial infarction (self-reported) 3.9 5.0 8.4 -2.0 1.7 2.9 -2.7 2.1 1.6
Deep venous thrombosis (DVT) (self-reported) 0.9 1.1 3.1 -0.4 0.0 1.8 -0.6 1.7 0.3
Heart disease (siblings) 2.7 3.3 10.9 0.9 0.9 3.3 -1.3 1.7 1.7
Alcohol drinker status: Previous 0.7 0.8 2.6 1.2 0.6 -0.0 0.7 -0.1 1.6
Pack years of smoking 2.0 2.9 8.1 -2.9 1.2 1.6 -1.4 1.0 1.6
Impedance of whole body 3.0 15.4 33.1 -0.5 1.3 -5.6 3.0 -5.8 -4.1
Leg fat mass (left) 2.4 9.2 20.8 1.4 2.0 4.2 -1.2 4.6 3.1
Arm predicted mass (left) 0.9 4.8 10.9 1.6 0.7 3.1 -1.5 3.3 1.7