Hub : Genes

FAM3C

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Not Sun Exposed Suprapubic	0.1500	0.0480	2.0e-04	0.092	NA	0.040	NA	0.096	9.9e-06	NA	3.1e-03	NA	6.2e-06
2	GTEx	Skin Sun Exposed Lower leg	0.1620	0.0380	2.8e-08	0.067	NA	0.098	NA	0.095	3.2e-06	NA	1.6e-08	NA	3.0e-08
3	METSIM	Adipose	0.1173	0.0267	8.0e-13	0.129	0.112	0.124	0.130	0.129	7.6e-19	2.0e-16	4.1e-18	7.0e-19	7.8e-19
4	ROSMAP	Brain Pre-frontal Cortex	0.0689	0.0231	3.7e-04	0.022	0.036	0.028	0.035	0.030	7.4e-04	1.6e-05	1.4e-04	2.3e-05	7.7e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.5	0.8	2.3	0.4	0.7	0.5	-1.5
Bipolar Disorder or Schizophrenia	1.0	2.5	3.3	1.8	1.8	1.2	-1.5
Depressed Affect (Nagel 2018)	0.4	0.8	2.7	-0.2	-1.6	0.3	0.7
Depression (Nagel 2018)	0.3	0.4	1.4	-0.0	0.2	0.6	-1.2
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.5	-0.4	0.1	-0.4	-0.7
Neuroticism (Nagel 2018)	0.2	0.4	1.3	-0.0	-1.2	0.1	0.6
Schizophrenia (2018)	1.1	2.3	3.6	1.9	1.9	1.2	-0.7
Schizophrenia vs Biploar Disorder	7.7	10.1	14.6	3.3	2.4	3.0	3.8
Worry (Nagel 2018)	0.1	0.1	0.3	-0.0	-0.5	-0.1	-0.5
Alzheimer’s Disease (in mother)	0.7	0.9	2.3	0.7	1.5	0.8	0.1
Alzheimer’s Disease (in father)	0.4	0.4	1.0	0.4	1.0	0.4	-0.5
Alzheimer’s Disease (including proxy)	1.4	2.0	6.0	0.7	2.4	1.0	-0.8
Crohns Disease (2017)	0.3	0.7	2.6	0.1	0.5	0.2	-1.6
Irritable Bowel Disease (IBD)	0.7	1.6	5.3	0.2	1.0	0.4	-2.3
Ulcerative Colitis (UC)	0.6	1.0	3.8	-0.0	0.6	0.1	-1.9
Major Depression (MDD)	0.3	0.3	0.6	0.6	0.1	0.6	0.8
Reaction Time	1.3	2.5	5.0	-1.9	-0.7	-2.2	-1.1
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.4	0.1	-0.7	0.0	0.4
Breast Cancer	0.1	0.2	0.3	-0.5	-0.6	-0.3	-0.4
Ovarian Cancer	0.2	0.2	0.6	0.1	-0.1	0.6	-0.8
Prostate Cancer	0.3	0.5	1.5	-0.6	0.2	-1.2	-0.2
Age at First Birth	0.7	1.0	2.3	-0.0	1.5	0.1	-1.2
Bipolar Disorder (2011)	1.3	1.3	2.8	1.0	0.7	1.0	-1.7
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	1.0	0.7	0.5	-0.3
Coronary Artery Disease (CAD)	0.7	0.8	2.5	0.2	-1.6	0.2	0.8
Crohns Disease (2012)	0.6	0.9	1.7	1.2	1.3	0.7	-0.4
Mean Putamen Volume	0.5	0.6	1.4	-0.8	-1.2	-0.2	-0.7
Fasting Glucose	0.9	1.1	2.5	1.6	0.6	1.1	-0.2
HbA1C	0.4	0.5	1.3	-0.3	-0.3	-0.6	1.2
HDL Cholesterol	1.2	2.0	4.0	-2.0	-1.0	-1.4	-1.0
LDL Cholesterol	1.3	2.0	3.3	-1.4	-1.6	-1.8	0.5
Lupus	0.8	1.3	3.9	-0.8	-2.0	-0.7	0.1
Neuroticism (2016)	0.5	0.8	2.0	0.4	-1.0	-0.0	1.4
Primary Biliary Cirrhosis	2.0	2.9	5.3	2.3	2.1	1.3	0.6
Rheumatoid Arthritis	0.8	1.0	1.9	1.4	-0.6	1.2	0.6
Schizophrenia (2014)	2.4	5.3	9.7	2.8	3.1	1.9	0.2
Triglycerides	0.3	0.5	1.2	0.6	0.5	0.3	-1.1
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.4	-0.1	-0.6	0.1	-0.3
Ulcerative Colitis	0.5	0.7	1.4	0.8	0.8	0.6	-1.2
Blood Eosinophil Count	0.3	2.1	2.8	-1.6	-1.3	-1.7	-1.1
Blood Platelet Count	0.2	2.6	5.4	-0.4	-2.1	-0.6	2.3
Blood Red Count	0.0	0.2	0.4	0.4	-0.5	-0.2	0.6
Blood White Count	0.2	1.6	2.3	-1.4	-1.5	-1.5	-0.0
Heel T-Score	161.4	1283.8	2560.4	31.6	50.6	38.0	-11.5
BMI	0.7	4.2	6.9	2.4	1.9	2.6	-0.6
Height	0.4	7.9	10.4	-3.2	-3.2	-1.0	-3.2
Waist Hip Ratio (WHR)	2.5	11.4	33.9	-1.4	-5.8	-1.2	2.9
Systolic Blood Pressure	0.3	1.6	2.3	-1.0	-1.2	-1.5	1.4
Smoking Status	0.3	0.6	1.0	-0.5	-1.0	-0.9	0.7
Allergy or Eczema	0.1	0.2	0.8	-0.0	0.3	0.1	-0.9
Cardiovascular Disease	0.3	1.0	1.7	-0.6	-1.3	-1.3	0.6
Hypothyroidism (self reported)	0.3	0.7	1.7	0.8	1.3	0.7	-0.4
Respiratory disease	1.5	3.4	4.7	-2.2	-0.7	-2.0	-2.2
Type 2 Diabetes (T2D) (2018)	0.6	1.0	3.1	0.3	-1.0	0.1	1.8
Lung FEV1/FVC ratio	4.1	20.8	31.4	5.6	3.1	4.5	4.7
Lung FVC	0.5	2.5	3.8	2.0	1.6	1.8	-0.2
Neuroticism	0.4	0.9	1.9	0.9	-0.5	0.8	1.4
Chronotype (morning person)	0.5	1.2	3.3	1.0	0.1	0.8	1.8
Hair Pigment	0.1	2.3	3.3	-1.4	-1.8	-1.5	-1.3
Tanning	0.1	0.7	2.3	0.3	-0.5	-0.1	1.5
Hand grip strength (left)	1.1	3.0	5.9	2.1	0.8	2.4	-1.0
Number of treatments/medications taken	0.8	1.4	2.7	-0.6	-1.1	-1.6	1.2
Average weekly spirits intake	1.8	2.3	3.0	1.7	1.5	1.6	1.2
Sensitivity / hurt feelings	0.1	0.3	0.7	-0.1	-0.3	-0.4	0.8
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.4	-0.9	-0.6	-0.5	-1.2
Hearing difficulty/problems: Yes	3.5	5.3	8.0	-2.3	-2.8	-2.8	0.2
Relative age of first facial hair	1.6	3.4	5.7	-1.7	-2.2	-2.4	-0.7
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.1	1.1	0.7	0.2	-0.0
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.0	1.0	1.0	0.7	0.8
Ever had hysterectomy (womb removed)	0.4	0.4	1.4	-0.4	-0.3	-0.4	-1.2
Systolic blood pressure, automated reading	0.6	1.7	3.3	-0.4	-1.7	-0.8	1.8
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.6	0.7	0.5	0.8	0.7
Angina	0.4	0.5	2.0	0.0	0.1	-0.1	-1.4
Medication for hormone replacement therapy	2.4	2.7	4.0	2.0	2.0	1.4	0.9
Vitamin and mineral supplements	0.1	0.2	0.4	0.6	-0.0	0.6	0.1
Supplements: Zinc	0.8	0.9	1.6	-1.2	-1.1	-0.9	-0.2
Medication: Co-codamol	0.2	0.2	0.6	-0.0	-0.3	-0.8	-0.3
Medication: Metformin	0.1	0.2	0.5	0.1	0.7	0.2	0.3
Diabetes (father)	0.6	0.7	2.2	-0.5	-1.5	-0.5	0.2
Diabetes (mother)	1.3	1.6	2.9	-1.1	-1.7	-0.7	-1.4
Severe depression (siblings)	1.0	1.1	1.8	1.4	1.0	0.8	1.0
Pack years adult smoking proportion	0.3	0.4	1.3	0.7	0.1	1.1	0.3
Impedance of leg (right)	0.7	3.4	9.2	-1.5	-3.0	-1.6	0.0
Leg fat-free mass (left)	0.4	2.3	4.2	0.6	2.1	1.4	-1.6
Trunk fat percentage	0.2	0.6	1.3	0.6	0.1	1.0	-1.2
Hand grip strength (right)	1.3	3.5	7.2	2.2	0.7	2.7	-1.1
Townsend deprivation index at recruitment	0.7	1.0	2.1	-1.4	-0.2	-1.5	-0.4
Current tobacco smoking	0.1	0.2	0.4	-0.3	-0.6	-0.3	-0.3
Average weekly fortified wine intake	1.0	1.2	2.9	0.9	-0.5	0.9	1.7
Maternal smoking around birth	0.8	1.2	2.9	-0.5	-1.7	-1.2	-0.6
Fed-up feelings	0.5	1.0	2.7	-0.7	-1.7	-0.5	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	4.6	0.1	1.3	0.4	-2.2
Relative age voice broke	0.4	0.6	1.1	-0.2	-0.9	-0.7	1.0
Taking other prescription medications	0.4	0.6	1.3	-0.3	-1.1	-0.9	0.5
Age when periods started (menarche)	0.3	0.7	2.4	0.1	-0.5	-0.0	1.6
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.4	-0.1	0.5	-0.0	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	106.5	241.6	484.0	13.3	22.0	16.7	-5.2
Tinnitus: Yes, but not now, but have in the past	2.3	2.5	3.7	-1.5	-1.3	-1.5	-1.9
Qualifications: CSEs or equivalent	1.0	1.3	3.9	0.7	2.0	0.7	-0.4
Serious illness, injury or assault to yourself	0.6	0.7	1.7	-0.7	-1.3	-0.7	0.3
High blood pressure	0.2	0.4	1.4	0.4	0.4	-0.1	1.2
Hayfever, allergic rhinitis or eczema	0.1	0.3	1.1	-0.1	0.1	-0.1	-1.1
Multivitamins +/- minerals	0.9	1.2	3.1	0.5	1.8	0.6	-1.0
Stomach or abdominal pain in last month	0.4	0.5	0.8	-0.9	-0.1	-0.8	-0.6
Supplements: Glucosamine	0.5	0.6	1.2	-0.3	-1.1	-0.2	-1.0
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	4.7	-1.6	-1.0	-2.2	-1.4
Medication: Atenolol	0.9	1.1	1.8	-0.8	-1.2	-1.3	0.8
Medication: Levothyroxine sodium	0.6	1.0	1.4	1.0	1.0	1.2	0.8
Sitting height	0.4	2.9	7.6	-0.4	1.6	1.1	-2.8
Chronic bronchitis/emphysema (father)	1.7	2.0	3.2	-1.4	-1.8	-1.5	-0.8
High blood pressure (mother)	0.1	0.1	0.2	0.2	-0.2	0.2	0.5
Body mass index (BMI)	0.6	2.7	3.7	1.9	1.9	1.9	-0.6
Impedance of leg (left)	1.0	4.8	12.0	-1.8	-3.5	-1.9	-0.0
Leg predicted mass (left)	0.5	2.4	4.8	0.7	2.2	1.5	-1.4
Trunk fat mass	0.3	1.2	3.2	0.5	0.3	1.1	-1.8
Waist circumference	0.1	0.3	0.4	0.3	-0.6	0.6	-0.6
Number of incorrect matches in round	1.0	1.6	6.0	0.3	-0.4	0.4	2.4
Past tobacco smoking	0.4	0.8	1.5	0.9	0.9	1.2	0.4
Alcohol usually taken with meals	0.1	0.2	0.4	-0.1	0.6	-0.3	0.4
Nervous feelings	0.1	0.2	0.4	0.6	-0.1	0.5	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.3	0.3	-0.5	0.6	0.4
Hearing difficulty/problems with background noise	2.0	3.2	5.1	-1.0	-2.3	-1.8	1.8
Hair/balding pattern: Pattern 2	2.0	2.5	5.3	1.3	2.3	1.3	-1.2
Had menopause	0.5	0.6	1.5	0.8	0.2	0.6	1.2
Had other major operations	0.3	0.3	0.7	0.8	0.3	0.5	0.5
Forced vital capacity (FVC)	0.4	1.6	3.4	0.7	0.8	1.4	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	116.1	266.1	510.8	14.7	22.6	17.9	-4.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.7	-0.7	-1.3	-0.8	0.3
Qualifications: None of the above	1.6	3.4	7.0	-1.4	-2.6	-2.0	0.6
Financial difficulties in last 2 years	0.1	0.2	0.6	-0.0	0.0	0.0	-0.8
Mouth/teeth dental problems	0.5	0.8	2.2	-0.6	-1.5	-0.7	0.5
Heart attack	0.6	0.8	1.2	-1.1	-0.9	-0.9	-0.6
Allergy	0.6	1.3	1.6	1.2	0.9	1.2	1.3
Pain all over the body in last month	1.3	1.4	2.8	1.4	0.9	1.7	0.3
Diabetes (self-reported)	0.4	0.6	1.7	-0.2	-0.9	-0.2	1.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.5	0.4	-0.2	0.4	-0.7
Medication: Ramipril	0.7	0.9	1.8	1.0	0.6	1.3	0.7
Medication: Simvastatin	2.3	3.4	8.1	-1.3	-2.8	-1.8	0.8
Fluid intelligence score	1.1	2.3	2.9	-1.7	-1.3	-1.7	-1.3
Illnesses of siblings	0.2	0.2	0.4	0.2	-0.4	0.6	0.6
Neuroticism score	0.3	0.6	1.9	-0.0	-1.4	0.2	0.6
Weight	0.4	2.0	3.7	0.8	1.2	1.5	-1.9
Impedance of arm (right)	0.2	0.9	1.4	-1.0	-1.2	-1.1	0.3
Arm fat percentage (right)	0.6	2.4	3.5	1.7	1.7	1.9	-0.5
Trunk fat-free mass	0.2	1.3	2.9	0.1	1.0	1.1	-1.7
Hip circumference	0.6	2.7	4.8	1.1	2.2	1.6	-1.5
Time employed in main current job	2.4	2.7	4.5	1.6	1.2	1.6	2.1
Alcohol intake versus 10 years previously	0.8	1.1	3.2	-0.7	0.5	-0.8	-1.8
Father’s age at death	0.1	0.2	0.6	-0.5	0.0	-0.0	-0.7
Worrier / anxious feelings	0.1	0.2	0.6	-0.1	-0.8	-0.4	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.5	0.7	0.7	0.6	-0.2
Falls in the last year	0.4	0.6	1.1	-0.2	-1.0	-0.5	1.1
Hair/balding pattern: Pattern 3	0.5	0.7	1.2	-1.0	-0.5	-1.1	-0.7
Number of live births	1.0	1.4	5.4	0.6	0.1	0.1	2.3
Forced expiratory volume in 1-second (FEV1)	1.3	4.3	7.2	2.4	2.0	2.7	-0.2
Pulse rate	0.2	0.3	0.8	0.2	-0.4	0.5	-0.9
Happiness	0.9	1.0	3.6	0.3	0.5	0.4	-1.9
Noisy workplace	0.5	0.6	1.1	0.5	0.9	1.1	-0.5
Qualifications: A levels/AS levels or equivalent	0.6	1.2	1.8	0.6	1.2	1.3	-1.2
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.2	1.1	0.6	0.8	0.6
Mouth/teeth dental problems: Dentures	0.3	0.5	0.9	0.9	0.7	0.9	-0.0
Asthma	3.1	6.1	8.8	-2.9	-2.3	-3.0	-1.4
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.9	0.6	1.0	0.1	0.3
Medication: Cholesterol lowering	1.2	1.8	3.5	-1.2	-1.9	-1.2	-0.8
Depression (self-reported)	1.4	1.7	2.3	1.4	1.5	1.4	0.6
Medication: Lansoprazole	0.2	0.3	0.6	0.7	0.4	0.3	0.5
Prospective memory result	0.6	0.8	2.2	0.5	-0.6	0.4	1.5
Lung cancer (father)	4.3	5.0	7.2	-2.4	-2.6	-2.7	0.4
Illnesses of mother	0.1	0.1	0.3	0.6	0.1	0.1	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	3.8	1.9	1.1	1.9	-0.6
Pulse wave Arterial Stiffness index	2.3	2.6	3.4	-1.7	-1.7	-1.9	-1.1
Impedance of arm (left)	0.3	1.2	2.6	-1.1	-1.6	-1.1	0.3
Arm fat mass (right)	0.5	2.2	3.3	1.5	1.5	1.8	-0.9
Trunk predicted mass	0.2	1.2	2.8	0.1	0.9	1.0	-1.7
Standing height	0.3	3.4	6.9	-2.0	-1.5	-0.5	-2.6
Length of working week for main job	0.2	0.2	0.5	0.5	0.3	0.7	0.1
Exposure to tobacco smoke at home	1.7	1.9	2.8	-1.6	-1.0	-1.7	-1.2
Breastfed as a baby	1.2	1.5	4.5	-1.0	-2.1	-0.8	-0.3
Tense / ‘highly strung’	0.3	0.5	2.1	0.0	0.1	-0.2	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.2	0.6	0.4	0.6	-1.1
Hair/balding pattern: Pattern 4	0.2	0.6	2.0	0.3	-0.4	0.4	1.4
Birth weight of first child	1.1	2.0	3.2	1.4	1.8	1.5	0.6
Peak expiratory flow (PEF)	1.0	2.4	3.5	1.5	1.8	1.9	0.7
Pulse wave reflection index	0.1	0.1	0.3	-0.4	-0.2	-0.5	0.0
Ever highly irritable/argumentative for 2 days	1.3	1.6	5.7	-0.3	0.6	0.0	-2.4
Loud music exposure frequency	0.8	0.8	1.8	-1.0	0.2	-0.7	-1.3
Qualifications: O levels/GCSEs or equivalent	1.5	2.3	4.2	0.9	2.0	2.0	-0.6
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.2	-0.4	1.5	-0.2	-0.5
Blood clot in the leg (DVT)	0.5	0.6	1.1	1.1	0.3	1.0	-0.5
Medication: Paracetamol	0.5	0.8	2.7	0.7	-0.0	-0.1	1.6
Headache pain in last month	0.3	0.6	0.9	1.0	0.9	0.7	0.4
Medication for cholesterol, blood pressure or diabetes	2.3	3.8	7.0	1.9	2.6	2.1	0.5
Glaucoma (self-reported)	4.3	5.1	7.7	2.2	2.1	1.8	2.8
Gout (self-reported)	0.1	0.2	0.6	0.4	0.2	0.8	-0.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	0.6	0.7	0.8	0.7	0.7
Medication: Amlodipine	0.2	0.3	0.7	-0.8	-0.3	-0.6	0.4
Medication: Ventolin 100micrograms inhaler	1.7	2.2	3.4	-1.5	-1.4	-1.9	-1.2
Birth weight	0.4	0.9	1.7	-1.3	-0.1	-1.3	0.5
Chronic bronchitis/emphysema (mother)	1.8	2.0	4.2	-1.4	-2.0	-1.4	-0.4
High blood pressure (siblings)	0.5	0.8	1.9	0.8	1.4	0.6	0.4
Forced vital capacity (FVC), Best measure	0.4	1.4	3.0	0.9	0.4	1.3	-1.7
Body fat percentage	0.2	0.7	1.3	0.8	0.3	1.0	-1.1
Leg fat percentage (right)	0.2	0.9	1.5	1.2	0.3	1.2	-0.6
Arm fat-free mass (right)	0.1	0.8	2.2	-0.1	0.5	0.8	-1.5
Exposure to tobacco smoke outside home	1.3	1.7	2.0	-1.4	-1.4	-1.4	-0.9
Comparative body size at age 10	0.2	0.5	0.9	0.9	1.0	0.6	0.0
Number of full brothers	0.4	0.5	1.0	-0.2	1.0	-0.1	-0.9
Worry too long after embarrassment	1.6	2.6	7.1	1.4	0.2	1.2	2.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	3.0	0.6	1.7	0.5	0.3
Wheeze or whistling in the chest in last year	0.7	1.3	2.0	-1.2	-0.8	-1.4	-1.0
Number of children fathered	0.2	0.2	0.4	0.3	0.3	0.4	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.8	0.0	0.0	0.1	-1.7
Age at first live birth	0.4	0.7	2.7	-0.3	-0.0	-0.3	-1.6
Pulse wave peak to peak time	1.8	2.2	2.9	1.5	1.7	1.7	0.8
Health satisfaction	0.4	0.5	1.7	0.3	0.2	0.0	-1.3
Shortness of breath walking on level ground	0.4	0.4	1.0	-0.5	-1.0	-0.6	-0.2
Qualifications: College or University degree	0.2	0.8	2.0	0.7	1.4	0.3	-0.7
Eye problems/disorders: None of the above	0.4	0.5	1.0	0.5	0.3	0.8	-1.0
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.9	0.9	0.2	0.8	0.7
Emphysema/chronic bronchitis	3.2	3.6	6.6	-2.2	-1.4	-2.6	-1.1
Medication for pain relief, constipation, heartburn	0.7	1.2	2.2	0.5	1.1	1.5	-1.1
Neck or shoulder pain in last month	1.0	1.4	3.5	-1.0	-1.9	-0.8	-0.4
Medication: Blood pressure	2.3	4.0	5.9	-2.0	-2.4	-2.4	-0.4
Angina (self-reported)	0.4	0.6	1.7	0.5	0.5	0.3	-1.3
Migraine (self-reported)	1.9	2.4	3.1	1.5	1.8	1.2	1.7
Medication: Ibuprofen	0.1	0.2	0.3	0.4	0.4	-0.0	0.6
Medication: Allopurinol	0.7	0.9	2.1	-0.9	-1.5	-0.8	-0.2
Medication: Omeprazole	0.9	1.1	2.6	-0.9	-1.0	-1.6	-0.4
Medication: Seretide 50 evohaler	0.4	0.5	1.1	0.3	-1.0	0.6	-0.7
Mean time to correctly identify matches	1.5	2.9	4.7	-1.8	-1.1	-2.2	-1.6
Heart disease (mother)	0.2	0.2	0.5	0.2	-0.7	-0.0	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.8	-0.9	-0.5	-0.7	0.2
Whole body fat mass	0.3	1.1	2.9	0.6	0.5	1.0	-1.7
Leg fat mass (right)	0.4	1.4	2.0	1.0	0.9	1.3	-1.4
Arm predicted mass (right)	0.2	1.1	2.8	0.2	0.8	1.1	-1.7
Pulse rate, automated reading	2.6	8.5	15.3	3.1	3.0	3.9	0.1
Alcohol intake frequency.	0.3	0.7	1.7	-0.4	0.8	-1.3	-0.6
Comparative height size at age 10	1.1	5.9	7.8	-2.7	-2.6	-1.4	-2.8
Number of full sisters	1.2	1.5	2.9	-1.3	0.3	-1.0	-1.7
Suffer from ‘nerves’	0.3	0.5	0.7	0.7	0.9	0.5	-0.7
Overall health rating	0.4	0.9	1.5	-0.7	-1.2	-0.9	-0.7
Chest pain or discomfort	0.3	0.4	0.6	-0.6	-0.3	-0.8	-0.6
Had major operations	0.5	0.6	0.8	-0.5	-0.9	-0.6	-0.9
Age at last live birth	0.7	1.0	2.4	0.6	1.6	0.7	-0.8
Family relationship satisfaction	0.5	0.6	1.1	0.5	1.0	0.5	-0.9
Leg pain on walking	0.2	0.2	0.6	-0.5	-0.7	-0.1	-0.2
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	3.6	1.4	1.9	1.8	0.6
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.8	0.4	-1.1	0.5	1.3
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.3	-0.5	0.6	-0.3	-0.4
Medication: Aspirin	0.3	0.4	0.8	-0.4	-0.9	-0.6	0.4
Supplements: Vitamin C	1.3	1.5	3.7	-1.1	-1.9	-0.8	0.7
Knee pain experienced in last month	0.1	0.1	0.2	0.3	0.2	0.2	0.4
Hypertension (Self-reported)	0.2	0.6	1.3	-0.2	-0.5	-0.8	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	1.7	0.1	0.3	-0.6	-1.3
Illnesses of father: Heart disease	0.5	0.8	2.8	-0.2	-0.4	-0.3	-1.7
Illnesses of siblings: Diabetes	0.1	0.1	0.1	0.1	-0.3	-0.3	0.4
Smoking status: Previous	1.2	1.9	2.9	-1.4	-1.4	-1.7	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.2	0.1	0.3	0.4	-0.0
Whole body fat-free mass	0.3	1.7	2.8	0.4	1.5	1.3	-1.7
Leg fat-free mass (right)	0.4	2.4	4.9	0.7	2.2	1.5	-1.4
Arm fat percentage (left)	0.6	2.3	3.5	1.7	1.5	1.9	-0.6
Average weekly red wine intake	1.4	2.0	2.9	1.5	1.2	1.7	1.2
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.1	0.7	1.0	0.5	-0.3
Mood swings	0.3	0.6	1.4	-0.4	-1.2	-0.3	-0.8
Loneliness, isolation	0.8	1.1	3.0	-0.8	-1.7	-0.2	-0.9
Long-standing illness, disability or infirmity	0.3	0.5	1.5	-0.2	-0.2	-0.5	-1.2
Ever had bowel cancer screening	0.8	0.9	1.8	-0.6	-1.3	-0.9	0.8
Diabetes diagnosed by doctor	0.4	0.7	1.5	-0.4	-1.2	-0.3	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.2	0.6	1.1	0.5	0.5
Friendships satisfaction	1.3	1.6	2.8	1.3	1.7	1.3	-0.4
Qualifications: nursing, teaching	0.5	0.7	1.2	0.7	1.0	1.1	-0.5
Commuting to job workplace: Walk	1.3	1.4	2.2	-1.5	-0.0	-1.2	-1.4
Eye problems/disorders: Cataract	1.6	1.9	3.0	-1.5	-1.7	-1.3	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.4	0.0	0.3	0.2	-1.2
Medication for cholesterol	1.4	2.1	3.4	-1.6	-1.2	-0.9	-1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.3	-0.4	-1.1	-0.7	0.2
Back pain experienced in last month	0.4	0.6	1.8	-0.6	-0.2	-0.5	1.4
Mineral and other dietary supplements	0.9	1.3	2.2	1.1	1.5	1.2	-0.0
Breast cancer (self-reported)	2.6	3.1	10.7	-1.0	-3.3	-1.0	-0.1
Asthma (self-reported)	2.7	5.3	7.9	-2.7	-2.0	-2.8	-1.4
Osteoporosis (self-reported)	5.6	6.9	13.1	-2.4	-2.4	-3.6	1.7
Osteoarthritis (self-reported)	0.7	0.9	3.2	0.2	0.7	0.0	-1.8
Medication: Aspirin	0.3	0.4	1.1	0.4	-0.4	-0.1	1.1
Medication: Gliclazide	0.1	0.1	0.2	0.3	0.5	0.1	-0.2
Illnesses of father: None of the above (group 1)	0.1	0.1	0.1	-0.3	0.0	-0.3	0.4
Smoking status: Current	0.0	0.0	0.1	0.0	-0.3	0.0	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.2	4.7	2.2	0.9	1.7	-0.5
Whole body water mass	0.3	1.6	2.6	0.3	1.5	1.2	-1.6
Leg predicted mass (right)	0.5	2.5	5.1	0.7	2.3	1.5	-1.4
Arm fat mass (left)	0.5	2.1	3.3	1.5	1.4	1.8	-1.0
Number of self-reported non-cancer illnesses	0.2	0.4	0.7	-0.5	-0.4	-0.8	0.6
Average weekly champagne plus white wine intake	0.8	1.1	1.9	-1.3	-1.4	-0.9	-0.3
Miserableness	0.2	0.4	1.1	-0.6	-1.0	-0.1	-0.1
Guilty feelings	0.5	0.8	1.5	-0.9	-1.2	-0.7	-0.4
Wears glasses or contact lenses	1.1	1.3	2.0	1.4	-0.1	1.4	1.1
Ever taken oral contraceptive pill	1.3	1.4	4.5	-0.9	0.4	-0.5	-2.1
Hearing aid user	2.6	3.0	5.2	1.9	0.2	1.7	2.3
Mother’s age at death	0.2	0.3	0.8	0.4	0.2	0.9	-0.4
Financial situation satisfaction	0.4	0.5	1.1	-0.8	0.5	-0.4	-1.0
Tinnitus: Yes, now most or all of the time	2.5	2.9	4.2	1.7	1.6	1.4	2.0
Commuting to job workplace: Public transport	0.5	0.6	1.8	-0.6	0.0	-0.2	-1.3
Eye problems/disorders: Glaucoma	6.3	7.5	8.5	2.9	2.9	2.3	2.8
Medication: Blood pressure	1.6	3.1	5.4	1.7	1.4	1.4	2.3
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.6	0.6	-0.6	0.8	0.3
Supplements: Fish oil (including cod liver oil)	1.0	1.3	1.8	-1.4	-1.3	-1.3	0.2
High cholesterol (Self-reported)	0.5	1.0	3.2	-0.0	-1.8	-0.0	0.8
Medication: Bendroflumethiazide	0.2	0.3	0.6	0.0	0.6	-0.5	0.8
Medication: Paracetamol	0.5	0.7	2.2	0.7	-0.5	0.0	1.5
Medication: Lisinopril	0.1	0.1	0.3	-0.2	-0.5	0.1	0.3
Medication: Atorvastatin	0.1	0.1	0.4	0.3	0.2	0.6	-0.0
Illnesses of father: High blood pressure	0.3	0.4	0.9	0.3	0.6	0.4	0.9
Alcohol drinker status: Never	0.7	0.8	1.7	-0.6	0.3	-1.0	1.3
Ever smoked	0.1	0.1	0.3	-0.3	-0.2	-0.6	0.2
Basal metabolic rate	0.3	1.8	2.8	0.5	1.5	1.4	-1.7
Leg fat percentage (left)	0.2	0.6	1.2	1.1	0.1	1.0	-0.4
Arm fat-free mass (left)	0.2	1.1	1.7	0.4	1.1	1.2	-1.3
Number of operations (self-reported)	0.2	0.3	0.8	0.9	-0.1	0.7	0.3
Average weekly beer plus cider intake	0.1	0.1	0.3	0.1	0.5	0.5	-0.0
Irritability	0.2	0.3	0.4	-0.4	-0.6	-0.3	-0.6
Risk taking	1.3	1.9	2.8	1.4	1.0	1.3	1.7
Ever had prostate specific antigen (PSA) test	0.9	1.1	3.7	-0.4	-0.1	-0.6	-1.9
Fractured/broken bones in last 5 years	19.9	25.7	47.6	-4.6	-6.9	-5.3	2.4
Age started oral contraceptive pill	0.2	0.3	0.6	0.1	-0.8	0.6	-0.2
Diastolic blood pressure, automated reading	0.3	0.9	2.5	-0.6	-1.6	-0.3	0.6
Ever depressed for a whole week	0.4	0.5	1.7	-0.3	0.0	-0.5	-1.3
Unable to work because of sickness or disability	0.0	0.0	0.1	-0.0	-0.0	-0.2	0.2
Commuting to job workplace: Cycle	0.7	0.9	1.7	-0.4	1.3	-0.5	-1.2
Myopia	2.4	3.5	4.1	-2.0	-2.0	-1.9	-1.6
Vascular/heart problems diagnosed by doctor	0.2	0.6	2.1	-0.3	0.4	0.3	-1.5
Cholesterol lowering medication	0.7	1.1	3.1	0.7	-0.8	0.3	1.8
Medication: Omeprazole (e.g. Zanprol)	1.2	1.4	3.3	-0.9	-1.2	-1.8	-0.1
Pain experienced in last month	0.1	0.2	0.8	0.1	0.9	-0.1	0.1
Supplements: Calcium	3.1	3.5	4.8	-1.3	-2.2	-1.9	1.9
Basal cell carcinoma (self-reported)	0.1	0.1	0.3	-0.2	-0.5	-0.2	0.2
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.8	-0.9	-0.7	-0.6	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.0	1.0	0.2	0.9	-0.4
Heart disease (siblings)	0.1	0.1	0.4	0.6	0.1	0.3	0.0
Alcohol drinker status: Previous	1.7	2.0	2.9	1.7	1.5	1.6	-0.5
Pack years of smoking	0.1	0.1	0.5	0.2	-0.1	0.7	-0.1
Impedance of whole body	0.6	2.8	7.2	-1.3	-2.7	-1.4	0.5
Leg fat mass (left)	0.3	1.2	1.6	1.0	0.8	1.3	-1.2
Arm predicted mass (left)	0.3	1.3	2.0	0.7	1.3	1.4	-1.1