TWAS hub - FAM210A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cortex	0.443	0.1330	8.6e-03	-0.010	NA	-0.008	NA	-0.009	7.9e-01	NA	6.2e-01	NA	0.7000
2	GTEx	Brain Hippocampus	0.382	0.0993	1.6e-03	0.196	NA	0.014	NA	0.070	2.4e-05	NA	1.5e-01	NA	0.0100
3	GTEx	Cells Transformed fibroblasts	0.207	0.0570	2.5e-04	0.000	NA	0.087	NA	0.034	2.9e-01	NA	4.3e-07	NA	0.0014
4	GTEx	Nerve Tibial	0.248	0.0649	6.4e-05	0.021	NA	0.080	NA	0.036	1.2e-02	NA	2.6e-06	NA	0.0013

Trait	Avg chi2 ratio	Avg chi2	Max chi2	2	3	4
Heel T-Score	6.1	48.6	146.4	-3.1	6.2	12.1
Heel bone mineral density (BMD) T-score, automated (right)	3.9	8.9	29.1	-0.7	2.5	5.4
Heel bone mineral density (BMD) T-score, automated (left)	3.5	8.0	29.1	-0.7	1.5	5.4
Number of incorrect matches in round	2.6	4.3	14.4	-3.8	-0.6	-1.5
Health satisfaction	2.6	3.4	5.9	1.6	-2.4	-2.3
Leg pain on walking	2.4	3.0	6.5	1.8	-1.5	-2.6
Length of working week for main job	2.3	2.5	7.1	0.9	1.5	2.7
Osteoporosis (self-reported)	2.3	2.8	7.4	-1.0	-2.7	-1.7
Crohns Disease (2017)	2.2	4.8	13.1	-0.9	3.6	2.3
Diabetes (father)	2.2	2.7	7.1	0.1	-2.7	-1.9
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	6.9	1.7	-2.6	-1.1
Angina (self-reported)	2.0	2.6	6.3	-1.4	-2.5	-1.5
Blood clot in the leg (DVT)	1.9	2.4	6.4	1.4	-2.5	-1.1
Angina	1.8	2.3	5.2	-1.4	-2.3	-1.4
Had other major operations	1.8	2.2	4.7	2.2	-1.2	-1.6
Irritable Bowel Disease (IBD)	1.7	4.0	11.7	-0.8	3.4	1.9
Hypothyroidism (self reported)	1.7	3.9	9.7	-3.1	-1.9	-1.5
Commuting to job workplace: Walk	1.7	1.9	7.2	2.7	0.4	0.3
Crohns Disease (2012)	1.5	2.3	6.7	0.5	2.6	1.6
Fractured/broken bones in last 5 years	1.5	1.9	7.2	0.5	0.0	-2.7
Ever used hormone-replacement therapy (HRT)	1.4	1.7	3.7	-0.1	-1.9	-1.8
Average weekly fortified wine intake	1.4	1.7	5.2	-1.2	0.3	-2.3
Age at last live birth	1.4	2.0	5.0	1.6	2.2	0.8
Medication for cholesterol	1.4	2.1	4.3	-2.0	0.3	2.1
Triglycerides	1.3	2.2	3.6	1.6	1.6	1.9
Back pain experienced in last month	1.3	1.9	4.6	2.2	-1.5	-1.0
Medication: Aspirin	1.3	1.7	5.8	-0.6	-0.9	-2.4
Ever had prostate specific antigen (PSA) test	1.3	1.4	3.5	0.7	1.3	1.9
Bipolar Disorder (2011)	1.2	1.2	2.7	1.4	-1.7	0.5
HDL Cholesterol	1.2	1.9	6.5	-2.6	-0.4	-1.0
Average weekly spirits intake	1.2	1.5	3.4	1.3	-1.8	0.8
Heart attack	1.2	1.5	4.0	-0.8	-2.0	-1.3
Qualifications: O levels/GCSEs or equivalent	1.2	2.0	4.6	1.4	2.1	1.2
Emphysema/chronic bronchitis	1.2	1.4	3.0	0.8	-1.4	-1.7
Number of full sisters	1.2	1.5	3.3	0.9	-1.4	-1.8
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	4.0	2.0	-1.3	-0.2
Ever had bowel cancer screening	1.2	1.4	4.2	-0.9	2.0	0.8
Medication: Lisinopril	1.2	1.6	6.2	0.3	2.5	0.1
Ever smoked	1.2	2.1	4.3	-1.9	2.1	-0.6
Heart attack/myocardial infarction (self-reported)	1.2	1.6	4.6	-0.9	-2.1	-1.0
Bipolar Disorder (2018)	1.1	1.7	5.6	2.4	-0.7	0.8
Mean Putamen Volume	1.1	1.2	2.3	0.7	1.5	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	5.1	0.2	-2.3	-0.9
Past tobacco smoking	1.1	1.9	4.4	1.8	-2.1	0.1
Lung cancer (father)	1.1	1.3	4.7	0.4	-0.7	-2.2
High blood pressure (siblings)	1.1	1.6	4.3	1.0	-1.0	-2.1
Friendships satisfaction	1.1	1.3	4.3	-0.8	-2.1	-0.5
Breast cancer (self-reported)	1.1	1.3	4.3	-0.3	0.9	2.1
Basal cell carcinoma (self-reported)	1.1	1.3	4.5	0.6	-2.1	-0.8
Body Mass Index (BMI) (2010)	1.0	1.3	3.8	1.1	-1.9	-0.5
Type 2 Diabetes (T2D) (2012)	1.0	1.1	3.8	1.9	0.7	-0.5
Medication: Ventolin 100micrograms inhaler	1.0	1.3	4.1	1.0	2.0	0.5
Age at first live birth	1.0	1.8	6.7	0.4	2.6	0.6
Medication for pain relief, constipation, heartburn	1.0	1.6	5.0	-0.1	1.3	2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	3.3	0.4	-1.1	-1.8
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	3.7	0.2	-1.6	-1.9
Financial situation satisfaction	1.0	1.2	3.6	1.0	-1.9	-0.6
Commuting to job workplace: Cycle	1.0	1.2	3.2	-0.0	1.8	1.2
Chronotype (morning person)	0.9	2.0	5.9	-2.4	1.3	0.5
Townsend deprivation index at recruitment	0.9	1.2	2.7	-1.4	-1.7	0.5
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	1.5	1.1	-1.0	-1.2
Supplements: Glucosamine	0.9	1.2	3.3	0.6	1.1	1.8
Pulse wave Arterial Stiffness index	0.9	1.1	2.2	1.5	-0.2	-1.4
Shortness of breath walking on level ground	0.9	1.0	2.4	1.6	1.0	-0.9
Chest pain or discomfort	0.9	1.3	2.8	1.2	-0.9	-1.7
Medication: Aspirin	0.9	1.1	3.5	-0.1	-1.0	-1.9
Miserableness	0.9	1.5	5.9	-2.4	-0.3	0.2
Ever depressed for a whole week	0.9	1.1	2.2	-0.4	1.4	1.5
Ovarian Cancer	0.8	1.1	3.3	0.6	0.8	1.8
Lung FVC	0.8	3.8	13.0	-3.6	1.2	1.0
Fed-up feelings	0.8	1.5	4.7	0.8	-2.2	-0.9
Happiness	0.8	1.0	2.0	1.4	-1.3	-0.6
Prospective memory result	0.8	0.9	2.2	-0.8	-1.5	-1.0
Exposure to tobacco smoke outside home	0.8	1.0	3.7	-0.1	-1.9	-0.6
Number of full brothers	0.8	0.9	2.5	-1.0	0.6	1.6
Pulse wave peak to peak time	0.8	1.0	2.1	-1.4	0.1	1.4
Medication: Seretide 50 evohaler	0.8	0.9	2.5	-1.6	-0.8	-0.7
Mean time to correctly identify matches	0.8	1.5	5.6	-2.4	-0.3	-0.5
Medication: Bendroflumethiazide	0.8	1.2	2.6	1.4	0.5	-1.6
Alcohol drinker status: Never	0.8	1.0	1.9	1.3	-1.4	-0.6
Number of treatments/medications taken	0.7	1.3	4.0	0.3	1.1	-2.0
Supplements: Zinc	0.7	0.8	2.4	-0.2	1.6	0.8
Pack years adult smoking proportion	0.7	1.1	2.6	0.8	-1.6	-1.1
Medication: Atenolol	0.7	0.8	1.1	-1.0	1.1	-1.1
Had menopause	0.7	0.8	2.9	-0.6	0.1	-1.7
Financial difficulties in last 2 years	0.7	0.9	2.8	1.7	-0.9	0.4
Diabetes (self-reported)	0.7	1.1	3.5	-0.7	-1.9	-0.7
Medication: Ramipril	0.7	0.9	2.5	1.0	1.6	-0.0
Pulse rate	0.7	1.1	1.7	1.1	1.3	1.3
Loud music exposure frequency	0.7	0.8	2.8	-1.7	-0.1	0.7
Comparative body size at age 10	0.7	1.8	4.5	-1.3	-1.0	-2.1
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.7	-0.7	1.3	1.2
Smoking status: Previous	0.7	1.0	2.2	-1.4	1.5	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.6	4.6	-2.1	1.3	-0.0
Hearing aid user	0.7	0.8	3.1	-0.3	0.2	1.8
Illnesses of father: High blood pressure	0.7	0.9	3.6	0.1	1.9	-0.1
Age started oral contraceptive pill	0.7	0.9	1.4	1.2	-1.1	-0.8
Unable to work because of sickness or disability	0.7	0.9	2.2	-1.5	1.2	-0.1
Ulcerative Colitis (UC)	0.6	1.1	3.5	-0.7	1.9	0.5
Reaction Time	0.6	1.1	4.0	-2.0	-0.6	0.2
Verbal and Numeric Reasoning (VNR)	0.6	1.4	3.1	-1.7	-0.7	-1.4
Fasting Glucose	0.6	0.7	1.6	0.7	0.7	1.3
Respiratory disease	0.6	1.4	3.3	-1.1	-1.0	-1.8
Sensitivity / hurt feelings	0.6	1.0	3.7	0.4	-1.9	0.0
Qualifications: None of the above	0.6	1.2	3.5	-1.0	-1.9	-0.6
Noisy workplace	0.6	0.7	1.2	-1.1	-1.1	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.0	0.2	-1.1	-1.4
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.7	-1.6	-1.3	0.4
Forced vital capacity (FVC), Best measure	0.6	2.2	6.9	-2.6	1.4	0.2
Wheeze or whistling in the chest in last year	0.6	1.0	2.3	0.6	-1.2	-1.5
Had major operations	0.6	0.7	1.8	-1.0	-0.2	-1.4
Knee pain experienced in last month	0.6	0.9	1.7	1.3	0.7	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.3	1.1	0.5	1.1
Medication: Blood pressure	0.6	1.2	2.9	1.2	0.6	-1.7
Major Depression (MDD)	0.5	0.6	1.6	-0.9	-1.3	0.4
Breast Cancer	0.5	1.1	3.1	1.8	1.0	-0.6
Neuroticism	0.5	1.3	3.4	-0.0	-1.8	-1.3
Medication for hormone replacement therapy	0.5	0.5	1.1	1.1	-0.7	-0.8
Multivitamins +/- minerals	0.5	0.6	2.1	-0.5	1.5	0.1
Alcohol usually taken with meals	0.5	0.7	1.9	-0.9	1.4	-0.5
Illnesses of siblings	0.5	0.7	1.3	-1.1	0.9	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.1	0.8	0.5	-1.1
Illnesses of mother	0.5	0.6	1.4	1.2	-1.0	0.4
Birth weight of first child	0.5	0.9	3.3	-1.8	-0.1	0.6
Medication: Paracetamol	0.5	0.9	2.9	0.6	0.5	-1.7
Medication: Amlodipine	0.5	0.6	1.2	0.5	-1.1	-1.1
Medication: Omeprazole	0.5	0.6	1.6	-1.3	0.5	-0.8
Pulse rate, automated reading	0.5	1.7	5.4	2.3	1.2	-0.4
Family relationship satisfaction	0.5	0.6	1.2	-1.1	-1.0	-0.5
Illnesses of father: Heart disease	0.5	0.7	1.0	0.9	-0.9	-1.0
Mood swings	0.5	0.8	1.7	-0.6	-1.3	-1.1
Mineral and other dietary supplements	0.5	0.6	1.8	0.0	-1.4	-0.9
Illnesses of father: None of the above (group 1)	0.5	0.7	1.8	-1.3	0.3	0.9
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.8	0.6	-1.4	-0.1
Commuting to job workplace: Public transport	0.5	0.6	2.2	1.5	-0.4	-0.1
Risk taking	0.5	0.7	1.5	-0.0	1.2	1.1
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.5	-0.7	1.2	-0.6
Heart disease (siblings)	0.5	0.6	1.7	0.6	-1.3	-0.6
Bipolar Disorder or Schizophrenia	0.4	0.9	2.2	1.5	-1.0	0.7
Depressed Affect (Nagel 2018)	0.4	0.8	1.6	0.0	-1.3	-1.3
Depression (Nagel 2018)	0.4	0.6	1.8	-0.8	-1.4	-0.3
Neuroticism (Nagel 2018)	0.4	0.8	2.8	0.1	-1.7	-0.7
Age at First Birth	0.4	0.6	2.3	1.5	0.4	0.3
Primary Biliary Cirrhosis	0.4	0.6	2.2	1.5	0.4	0.4
Rheumatoid Arthritis	0.4	0.6	1.7	-0.7	1.3	0.3
Allergy or Eczema	0.4	1.1	2.3	-1.5	1.3	0.5
Medication: Co-codamol	0.4	0.5	1.4	0.6	1.2	-0.5
Qualifications: CSEs or equivalent	0.4	0.6	1.3	1.2	0.1	-1.0
Serious illness, injury or assault to yourself	0.4	0.5	1.2	-1.1	0.8	-0.5
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.9	-0.2	1.4	1.2
Stomach or abdominal pain in last month	0.4	0.5	1.2	1.0	0.2	-1.1
Chronic bronchitis/emphysema (father)	0.4	0.4	1.1	0.3	-0.8	-1.0
Waist circumference	0.4	1.5	2.5	1.6	-1.2	-1.4
Forced vital capacity (FVC)	0.4	1.5	5.2	-2.3	0.8	-0.2
Neuroticism score	0.4	0.8	2.4	0.0	-1.6	-0.9
Time employed in main current job	0.4	0.4	1.1	1.0	0.1	0.7
Father’s age at death	0.4	0.6	1.7	-1.3	-0.5	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.7	0.8	-0.1	-1.3
Hair/balding pattern: Pattern 3	0.4	0.6	1.8	0.7	-0.3	-1.3
Medication: Lansoprazole	0.4	0.5	1.3	0.5	-0.6	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.1	4.0	-2.0	0.8	0.1
Impedance of arm (left)	0.4	1.9	3.2	-1.6	1.4	1.8
Glaucoma (self-reported)	0.4	0.4	1.0	0.6	0.6	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.8	0.9	-0.9	0.3
Leg fat mass (right)	0.4	1.4	3.8	1.9	-1.1	-0.9
Overall health rating	0.4	0.9	2.1	1.5	-0.8	-1.0
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.1	0.7	0.7	-1.1
Medication: Atorvastatin	0.4	0.5	1.2	-1.1	-0.7	-0.3
Average weekly beer plus cider intake	0.4	0.6	1.7	-0.7	-1.3	0.2
Alcohol drinker status: Previous	0.4	0.4	1.5	-1.2	-0.4	0.1
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.2	-1.1	-1.0	-1.0
Alzheimer’s Disease (in mother)	0.3	0.4	1.3	0.3	0.3	-1.1
Prostate Cancer	0.3	0.5	1.2	-0.8	0.3	1.1
Neuroticism (2016)	0.3	0.4	1.2	1.1	-0.5	0.1
Blood White Count	0.3	2.5	6.1	0.3	2.5	2.0
Systolic Blood Pressure	0.3	1.3	4.2	0.3	2.1	0.9
Smoking Status	0.3	0.7	1.5	-1.2	0.4	1.1
Lung FEV1/FVC ratio	0.3	1.4	3.0	1.3	1.0	1.7
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.9	0.9	-0.2	-0.9
Diabetes (mother)	0.3	0.4	1.3	-0.5	-1.1	-0.0
Relative age voice broke	0.3	0.4	1.4	1.2	0.3	0.5
Age when periods started (menarche)	0.3	0.7	1.5	1.1	-1.2	-0.6
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.8	-0.4	-0.9	-0.4
Medication: Levothyroxine sodium	0.3	0.4	1.4	-0.6	-1.2	-0.3
Hearing difficulty/problems with background noise	0.3	0.5	1.2	1.1	-0.6	-0.6
Mouth/teeth dental problems	0.3	0.4	1.0	-1.0	-0.3	0.7
Impedance of arm (right)	0.3	1.3	1.8	-1.2	1.3	1.4
Falls in the last year	0.3	0.4	0.7	-0.8	0.8	-0.7
Peak expiratory flow (PEF)	0.3	0.7	2.8	-0.0	0.3	-1.7
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.7	0.3	0.8	0.7
Headache pain in last month	0.3	0.6	1.9	-0.4	-0.6	-1.4
Birth weight	0.3	0.7	2.0	-0.8	1.4	0.4
Leg fat percentage (right)	0.3	1.1	3.2	1.8	-1.0	-0.5
Arm fat-free mass (right)	0.3	1.5	3.1	1.8	-1.2	-1.1
Number of children fathered	0.3	0.4	1.5	1.2	0.3	-0.0
Medication: Ibuprofen	0.3	0.3	0.9	0.3	-0.6	-0.9
Heart disease (mother)	0.3	0.4	1.2	-0.4	-0.3	-1.1
Arm predicted mass (right)	0.3	1.4	4.1	2.0	-0.8	-0.9
Average weekly red wine intake	0.3	0.4	1.4	-1.2	0.4	-0.3
Long-standing illness, disability or infirmity	0.3	0.4	1.5	-0.0	-0.2	-1.2
Diabetes diagnosed by doctor	0.3	0.5	2.1	-0.3	-1.4	-0.1
Medication: Gliclazide	0.3	0.4	0.8	0.8	0.9	-0.3
Ever taken oral contraceptive pill	0.3	0.3	0.8	0.9	0.6	-0.2
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.8	-0.9	0.7	0.5
Medication: Paracetamol	0.3	0.5	1.2	1.1	0.3	-0.8
Leg fat percentage (left)	0.3	1.0	2.5	1.6	-1.1	-0.5
Arm fat-free mass (left)	0.3	1.7	4.3	2.1	-1.0	-1.3
Irritability	0.3	0.5	1.3	0.7	-0.3	1.1
Cholesterol lowering medication	0.3	0.4	0.9	-0.7	-0.3	-0.9
Pain experienced in last month	0.3	0.6	1.5	0.1	-1.2	-0.9
Pack years of smoking	0.3	0.4	1.1	0.3	-1.0	-0.7
Impedance of whole body	0.3	1.4	4.4	-0.9	0.4	2.1
Leg fat mass (left)	0.3	1.3	3.2	1.8	-1.1	-0.9
Arm predicted mass (left)	0.3	1.5	3.5	1.9	-0.7	-1.4
HbA1C	0.2	0.2	0.7	0.2	-0.8	0.3
Schizophrenia (2014)	0.2	0.4	1.0	1.0	-0.5	0.7
Waist Hip Ratio (WHR)	0.2	0.9	1.8	1.2	-1.3	0.6
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.9	0.9	-0.8	-0.3
Hand grip strength (left)	0.2	0.6	1.3	0.7	0.8	-1.1
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.0	-0.4	-1.0	-0.0
Hearing difficulty/problems: Yes	0.2	0.3	0.9	0.5	0.1	0.9
Relative age of first facial hair	0.2	0.5	1.2	1.1	0.9	-0.0
Severe depression (siblings)	0.2	0.2	0.7	-0.9	0.2	-0.0
Impedance of leg (right)	0.2	0.9	3.6	0.2	-0.1	1.9
Leg fat-free mass (left)	0.2	0.9	1.9	1.4	-0.3	-1.2
Hand grip strength (right)	0.2	0.5	0.8	-0.9	0.6	-0.8
Taking other prescription medications	0.2	0.3	0.7	-0.8	0.1	-0.8
High blood pressure	0.2	0.5	0.8	0.6	0.9	-0.9
Body mass index (BMI)	0.2	1.1	2.5	1.6	-0.6	-1.1
Impedance of leg (left)	0.2	1.1	4.1	-0.0	-0.6	2.0
Leg predicted mass (left)	0.2	0.8	1.9	1.4	-0.1	-1.1
Pain all over the body in last month	0.2	0.2	0.7	0.1	-0.4	0.8
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.0	-0.0	1.0	0.2
Medication: Simvastatin	0.2	0.4	1.0	0.3	1.0	-0.5
Fluid intelligence score	0.2	0.3	0.8	-0.5	0.9	0.5
Weight	0.2	1.1	2.9	1.7	-0.7	-1.1
Trunk fat-free mass	0.2	1.1	2.6	1.6	-0.4	-1.2
Number of live births	0.2	0.3	0.9	-0.1	-1.0	-0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.9	-1.4	0.3	-0.7
Mouth/teeth dental problems: Dentures	0.2	0.4	1.3	1.2	0.4	-0.3
Arm fat mass (right)	0.2	0.9	2.8	1.7	-0.4	-0.8
Trunk predicted mass	0.2	1.1	2.8	1.7	-0.3	-1.2
Exposure to tobacco smoke at home	0.2	0.3	0.7	0.1	0.8	0.6
Hair/balding pattern: Pattern 4	0.2	0.4	0.7	-0.9	-0.3	0.8
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.9	0.9	0.4	-0.0
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.6	-0.8	-0.3	0.6
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.9	-0.0	0.9	-0.1
Qualifications: College or University degree	0.2	0.5	1.8	-0.6	1.3	-0.3
Mouth/teeth dental problems: Loose teeth	0.2	0.3	1.1	0.3	0.1	-1.0
Neck or shoulder pain in last month	0.2	0.2	0.4	-0.5	0.7	-0.5
Medication: Blood pressure	0.2	0.3	1.2	0.2	1.1	-0.3
Migraine (self-reported)	0.2	0.3	0.9	-0.2	1.0	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.9	0.2	0.2	0.9
Comparative height size at age 10	0.2	0.9	2.7	0.2	-0.9	-1.6
Hypertension (Self-reported)	0.2	0.6	1.2	0.4	1.0	-1.1
Illnesses of siblings: Diabetes	0.2	0.3	1.1	-1.0	-0.2	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.2	-0.5	-0.1	-1.1
Whole body fat-free mass	0.2	1.0	2.2	1.5	-0.5	-1.3
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.8	0.1	0.5	0.9
Loneliness, isolation	0.2	0.3	0.9	0.2	-1.0	0.5
Eye problems/disorders: Cataract	0.2	0.2	0.6	-0.4	-0.8	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.7	-0.5	-0.2	0.8
Whole body water mass	0.2	1.2	2.6	1.6	-0.5	-1.4
Arm fat mass (left)	0.2	0.9	3.1	1.8	-0.4	-0.6
Mother’s age at death	0.2	0.3	0.9	0.6	-0.9	-0.0
Basal metabolic rate	0.2	1.1	3.1	1.8	-0.5	-1.1
Number of operations (self-reported)	0.2	0.2	0.6	-0.1	-0.6	-0.8
Diastolic blood pressure, automated reading	0.2	0.6	2.2	0.4	0.1	-1.5
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.5	-0.3	-0.6	1.2
Supplements: Calcium	0.2	0.2	0.6	0.2	0.2	-0.8
Schizophrenia (2018)	0.1	0.3	0.9	0.2	-1.0	0.2
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	0.1	0.5	0.2
Worry (Nagel 2018)	0.1	0.2	0.4	0.4	-0.6	-0.6
Alzheimer’s Disease (in father)	0.1	0.1	0.3	-0.6	0.4	-0.2
Alzheimer’s Disease (including proxy)	0.1	0.2	0.6	-0.3	0.4	-0.8
Coronary Artery Disease (CAD)	0.1	0.1	0.4	0.3	0.3	-0.6
LDL Cholesterol	0.1	0.1	0.2	-0.0	0.4	0.4
Lupus	0.1	0.1	0.3	0.1	-0.1	0.6
Ulcerative Colitis	0.1	0.2	0.7	-0.1	0.8	0.1
Blood Eosinophil Count	0.1	0.5	0.9	-1.0	-0.9	0.4
BMI	0.1	0.6	2.5	1.6	0.2	0.0
Cardiovascular Disease	0.1	0.3	0.5	0.7	0.6	-0.4
Tanning	0.1	1.7	5.9	-2.4	-0.9	-0.3
Systolic blood pressure, automated reading	0.1	0.4	1.0	-0.8	0.1	-1.0
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	-0.0	-0.5	0.1
Vitamin and mineral supplements	0.1	0.2	0.7	0.3	-0.8	0.0
Medication: Metformin	0.1	0.1	0.4	0.6	0.1	-0.0
Trunk fat percentage	0.1	0.3	0.8	0.9	0.2	0.5
Maternal smoking around birth	0.1	0.2	0.7	0.3	-0.8	-0.0
High blood pressure (mother)	0.1	0.1	0.4	-0.2	0.6	-0.1
Trunk fat mass	0.1	0.4	1.5	1.2	-0.1	-0.0
Nervous feelings	0.1	0.2	0.6	0.3	-0.8	0.2
Hair/balding pattern: Pattern 2	0.1	0.1	0.3	-0.6	-0.1	0.3
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	-0.3	0.1	-0.5
Arm fat percentage (right)	0.1	0.4	1.4	1.2	0.2	-0.3
Hip circumference	0.1	0.6	1.2	1.1	-0.1	-1.0
Worrier / anxious feelings	0.1	0.1	0.2	0.5	-0.3	-0.3
Depression (self-reported)	0.1	0.1	0.5	-0.7	0.0	0.3
Breastfed as a baby	0.1	0.2	0.5	-0.0	-0.5	-0.7
Tense / ‘highly strung’	0.1	0.2	0.6	0.2	0.8	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.5	0.1	-0.6	-0.7
Gout (self-reported)	0.1	0.2	0.4	0.6	0.6	-0.3
Body fat percentage	0.1	0.4	1.4	1.2	-0.3	0.2
Worry too long after embarrassment	0.1	0.2	0.5	0.5	-0.3	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.5	0.4	-0.4
Eye problems/disorders: None of the above	0.1	0.1	0.2	-0.2	0.0	0.5
Medication: Allopurinol	0.1	0.1	0.4	-0.6	0.1	-0.3
Whole body fat mass	0.1	0.6	2.1	1.5	-0.4	-0.2
Alcohol intake frequency.	0.1	0.1	0.5	-0.0	-0.2	0.7
Suffer from ‘nerves’	0.1	0.1	0.5	0.7	0.3	-0.1
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.6	-0.8	0.1	-0.1
Supplements: Vitamin C	0.1	0.2	0.4	0.6	0.2	-0.6
Leg fat-free mass (right)	0.1	0.6	1.4	1.1	-0.3	-1.2
Arm fat percentage (left)	0.1	0.5	1.8	1.4	0.2	-0.1
Qualifications: nursing, teaching	0.1	0.2	0.4	-0.3	0.5	-0.6
Osteoarthritis (self-reported)	0.1	0.2	0.5	0.7	-0.5	-0.0
Leg predicted mass (right)	0.1	0.6	1.3	1.1	-0.2	-1.1
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	0.0	0.7	-0.5
Average weekly champagne plus white wine intake	0.1	0.2	0.6	-0.8	0.1	0.2
Guilty feelings	0.1	0.2	0.5	-0.3	-0.7	-0.5
Wears glasses or contact lenses	0.1	0.1	0.2	-0.2	-0.0	-0.4
Eye problems/disorders: Glaucoma	0.1	0.1	0.4	-0.4	0.3	0.6
High cholesterol (Self-reported)	0.1	0.2	0.4	-0.6	0.2	-0.6
Myopia	0.1	0.1	0.4	0.0	0.6	0.3
Blood Platelet Count	0.0	0.6	1.4	0.2	-1.2	0.9
Blood Red Count	0.0	0.4	1.1	0.8	-1.1	0.0
Height	0.0	0.4	0.9	-0.5	-1.0	-0.6
Hair Pigment	0.0	1.2	3.0	1.7	0.8	-1.0
Ever had hysterectomy (womb removed)	0.0	0.0	0.1	0.2	0.1	0.1
Current tobacco smoking	0.0	0.0	0.1	0.1	-0.3	0.1
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.1	0.1	-0.3	0.2
Sitting height	0.0	0.3	1.3	-0.1	-1.1	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.2	-0.4	-0.2	0.0
Allergy	0.0	0.1	0.2	0.3	0.3	-0.5
Alcohol intake versus 10 years previously	0.0	0.0	0.2	0.4	-0.0	0.0
Qualifications: A levels/AS levels or equivalent	0.0	0.0	0.1	-0.4	-0.1	0.1
Asthma	0.0	0.1	0.2	-0.4	0.3	-0.3
Medication: Cholesterol lowering	0.0	0.1	0.2	0.3	0.4	-0.1
Standing height	0.0	0.0	0.1	0.4	-0.2	-0.1
Pulse wave reflection index	0.0	0.0	0.1	0.3	-0.2	-0.2
Asthma (self-reported)	0.0	0.1	0.2	-0.2	0.5	-0.2
Smoking status: Current	0.0	0.0	0.1	-0.2	-0.1	0.3

Hub : Genes

FAM210A

Models

Trait associations