Hub : Genes

CD44

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0874	0.0367	7.5e-03	0.076	NA	0.082	NA	0.078	1.5e-06	NA	5.4e-07	NA	1.0e-06
2	NTR	Blood	0.0305	0.0109	4.3e-04	0.000	0.008	0.001	0.008	0.001	2.6e-01	8.7e-04	1.3e-01	9e-04	1.5e-01
3	YFS	Blood	0.1109	0.0243	7.8e-16	0.009	0.060	0.065	NA	0.055	5.2e-04	6.2e-19	2.0e-20	NA	2.0e-17

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.2	0.3	0.8	-0.9	0.1	-0.4
Bipolar Disorder or Schizophrenia	0.6	1.4	2.3	-1.5	-1.0	-1.0
Depressed Affect (Nagel 2018)	0.2	0.4	1.0	-0.4	-0.1	1.0
Depression (Nagel 2018)	0.3	0.4	0.7	-0.1	0.7	0.8
Intelligence (Savage-Jansen 2018)	0.6	1.8	2.9	0.4	1.7	1.5
Neuroticism (Nagel 2018)	0.0	0.1	0.2	0.2	-0.4	-0.2
Schizophrenia (2018)	0.7	1.4	1.8	-1.3	-1.3	-0.8
Schizophrenia vs Biploar Disorder	1.1	1.4	3.7	-0.3	-0.7	1.9
Worry (Nagel 2018)	0.2	0.4	0.6	0.7	-0.4	-0.7
Alzheimer’s Disease (in mother)	0.2	0.2	0.3	0.6	-0.6	0.1
Alzheimer’s Disease (in father)	0.5	0.5	1.3	1.2	-0.0	0.4
Alzheimer’s Disease (including proxy)	0.3	0.5	1.2	1.1	-0.2	0.5
Crohns Disease (2017)	1.8	4.0	7.3	1.9	2.7	1.0
Irritable Bowel Disease (IBD)	1.0	2.4	5.6	2.4	1.2	0.2
Ulcerative Colitis (UC)	0.4	0.8	1.9	1.4	-0.3	-0.7
Major Depression (MDD)	0.4	0.4	1.2	0.3	-1.1	0.1
Reaction Time	0.1	0.2	0.5	-0.2	-0.7	0.4
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.4	0.6	1.2	0.1
Breast Cancer	1.7	4.2	12.2	-0.6	-3.5	-0.2
Ovarian Cancer	0.9	1.2	3.4	-0.2	-1.9	0.1
Prostate Cancer	0.2	0.2	0.5	-0.1	0.4	-0.7
Age at First Birth	0.3	0.5	0.5	-0.7	0.6	-0.7
Bipolar Disorder (2011)	1.3	1.3	2.0	-1.4	-0.2	-1.4
Body Mass Index (BMI) (2010)	0.9	1.2	2.5	1.0	-1.6	-0.4
Coronary Artery Disease (CAD)	0.2	0.3	0.5	-0.5	-0.7	0.2
Crohns Disease (2012)	1.9	3.1	4.7	1.8	2.2	1.2
Mean Putamen Volume	0.4	0.4	1.1	-0.2	0.3	1.1
Fasting Glucose	1.0	1.2	3.2	-0.5	-1.8	-0.5
HbA1C	0.2	0.2	0.3	-0.3	-0.6	-0.3
HDL Cholesterol	0.9	1.5	2.5	0.5	1.3	1.6
LDL Cholesterol	0.6	1.0	1.5	-1.1	-0.3	-1.2
Lupus	10.1	15.3	44.6	6.7	-0.4	1.0
Neuroticism (2016)	1.0	1.4	3.7	1.9	0.5	-0.6
Primary Biliary Cirrhosis	2.6	3.8	10.0	3.2	-0.8	-0.8
Rheumatoid Arthritis	0.1	0.2	0.3	0.3	0.3	0.5
Schizophrenia (2014)	0.4	0.9	1.7	-1.3	-1.0	-0.3
Triglycerides	1.5	2.4	3.2	-1.4	-1.8	-1.4
Type 2 Diabetes (T2D) (2012)	2.0	2.3	3.3	1.4	-1.8	-1.3
Ulcerative Colitis	1.1	1.6	1.8	1.3	-1.2	-1.2
Blood Eosinophil Count	0.8	6.4	10.3	2.3	-3.2	-1.9
Blood Platelet Count	0.0	0.2	0.3	-0.3	0.6	-0.6
Blood Red Count	0.2	1.5	3.1	-1.8	1.1	0.4
Blood White Count	0.2	1.4	4.0	0.3	0.5	2.0
Heel T-Score	9.8	77.6	231.0	15.2	0.8	-1.1
BMI	0.7	3.8	10.1	0.7	-3.2	-0.9
Height	0.0	0.8	1.5	0.9	-1.2	-0.2
Waist Hip Ratio (WHR)	1.2	5.3	14.1	-1.3	0.4	3.8
Systolic Blood Pressure	0.1	0.3	0.5	-0.7	0.5	0.4
Smoking Status	1.3	3.1	7.7	0.6	-1.1	2.8
Allergy or Eczema	0.4	1.2	1.6	-1.0	-1.3	1.0
Cardiovascular Disease	0.5	1.8	2.7	1.0	-1.6	-1.3
Hypothyroidism (self reported)	4.4	10.2	28.5	-1.0	-5.3	-1.0
Respiratory disease	0.4	1.0	2.6	0.0	-1.6	-0.6
Type 2 Diabetes (T2D) (2018)	1.3	2.4	5.8	0.1	-2.4	-1.2
Lung FEV1/FVC ratio	1.3	6.8	13.1	-0.6	-3.6	-2.6
Lung FVC	0.4	2.1	3.1	-1.7	1.8	-0.7
Neuroticism	0.2	0.4	0.6	-0.8	0.8	-0.2
Chronotype (morning person)	0.3	0.6	1.5	0.5	-0.1	-1.2
Hair Pigment	0.4	11.7	21.0	4.6	-3.8	-0.3
Tanning	0.1	1.5	3.8	2.0	-0.1	0.8
Hand grip strength (left)	3.0	7.8	9.6	3.1	2.7	2.5
Number of treatments/medications taken	0.6	1.0	1.6	-1.1	-1.3	-0.5
Average weekly spirits intake	0.2	0.2	0.3	-0.5	-0.5	-0.3
Sensitivity / hurt feelings	0.3	0.5	1.4	-0.4	1.2	-0.3
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.2	-0.5	0.3	0.5
Hearing difficulty/problems: Yes	0.3	0.4	1.0	-0.3	0.4	1.0
Relative age of first facial hair	0.8	1.6	3.1	-1.8	-1.1	-0.5
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	2.8	1.2	-0.5	-1.7
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.1	-1.0	-1.0	0.2
Ever had hysterectomy (womb removed)	3.5	3.9	9.6	3.1	-0.7	1.3
Systolic blood pressure, automated reading	0.1	0.4	0.7	-0.9	-0.6	0.1
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.8	1.3	-0.4	-0.4
Angina	1.5	2.0	5.5	-0.1	-2.3	-0.6
Medication for hormone replacement therapy	0.7	0.8	2.1	-1.4	0.2	-0.6
Vitamin and mineral supplements	2.4	3.2	5.5	-2.0	-0.1	-2.3
Supplements: Zinc	0.7	0.7	1.2	0.1	-1.1	1.0
Medication: Co-codamol	0.6	0.7	2.0	-0.3	0.1	1.4
Medication: Metformin	0.2	0.3	0.7	-0.8	-0.5	0.2
Diabetes (father)	1.0	1.2	2.4	-0.5	-1.5	-1.0
Diabetes (mother)	0.1	0.1	0.2	-0.4	-0.1	0.3
Severe depression (siblings)	1.4	1.6	4.4	0.6	-2.1	0.1
Pack years adult smoking proportion	0.3	0.5	0.7	-0.6	-0.9	0.6
Impedance of leg (right)	0.3	1.7	3.0	-1.7	-1.1	-0.8
Leg fat-free mass (left)	0.2	1.0	1.4	1.1	-0.6	1.2
Trunk fat percentage	1.8	7.1	18.1	-0.7	-4.2	-1.6
Hand grip strength (right)	2.1	5.8	11.5	3.4	2.0	1.4
Townsend deprivation index at recruitment	1.0	1.4	4.0	-2.0	-0.4	0.0
Current tobacco smoking	0.8	1.2	3.3	0.4	-1.8	0.5
Average weekly fortified wine intake	0.6	0.7	1.9	-0.1	0.4	-1.4
Maternal smoking around birth	0.5	0.7	1.5	-0.7	-1.2	0.2
Fed-up feelings	0.1	0.3	0.6	-0.8	-0.4	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.1	-1.1	0.5	0.5
Relative age voice broke	0.3	0.4	0.5	-0.7	-0.5	-0.7
Taking other prescription medications	1.6	2.4	5.4	-1.1	-2.3	-0.8
Age when periods started (menarche)	0.1	0.3	0.8	-0.9	0.3	0.1
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	3.1	1.8	-0.1	0.9
Heel bone mineral density (BMD) T-score, automated (left)	5.3	12.1	34.0	5.8	1.5	0.4
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.6	0.8	-0.7	-0.4
Qualifications: CSEs or equivalent	0.4	0.5	1.2	0.4	-0.5	1.1
Serious illness, injury or assault to yourself	0.0	0.0	0.1	-0.1	-0.3	-0.0
High blood pressure	0.3	1.0	1.4	0.8	-1.2	-1.0
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.5	0.0	-1.0	1.2
Multivitamins +/- minerals	1.1	1.3	2.4	1.5	-0.7	1.1
Stomach or abdominal pain in last month	0.8	1.0	2.7	1.7	-0.2	-0.3
Supplements: Glucosamine	1.1	1.5	3.3	-0.7	-0.9	1.8
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.0	-0.1	-0.9	-1.0
Medication: Atenolol	1.1	1.4	2.9	-0.7	-0.9	-1.7
Medication: Levothyroxine sodium	3.8	6.4	15.4	-0.1	-3.9	-2.0
Sitting height	0.0	0.2	0.3	0.5	-0.3	-0.4
Chronic bronchitis/emphysema (father)	2.0	2.4	7.1	2.7	0.1	0.1
High blood pressure (mother)	0.9	1.3	2.2	1.5	1.3	-0.3
Body mass index (BMI)	0.5	2.3	6.7	0.3	-2.6	-0.3
Impedance of leg (left)	0.3	1.7	2.9	-1.7	-1.1	-1.0
Leg predicted mass (left)	0.2	1.0	1.6	1.3	-0.6	1.1
Trunk fat mass	1.3	5.5	15.5	0.0	-3.9	-1.0
Waist circumference	0.6	2.1	5.4	-0.9	-2.3	0.5
Number of incorrect matches in round	0.4	0.7	1.9	-0.1	0.5	1.4
Past tobacco smoking	0.3	0.6	1.7	-0.0	0.4	-1.3
Alcohol usually taken with meals	0.6	0.9	1.6	1.3	0.0	-1.1
Nervous feelings	0.2	0.4	1.1	-0.1	0.2	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	1.8	0.1	1.3	1.2
Hearing difficulty/problems with background noise	0.0	0.1	0.2	-0.0	-0.1	0.4
Hair/balding pattern: Pattern 2	1.7	2.1	2.7	1.1	-1.6	-1.5
Had menopause	0.6	0.7	1.2	-0.2	-1.1	-0.9
Had other major operations	0.7	0.9	1.4	1.2	-0.4	-1.0
Forced vital capacity (FVC)	0.7	2.5	4.4	-2.1	1.8	0.1
Heel bone mineral density (BMD) T-score, automated (right)	6.8	15.6	45.4	6.7	1.2	0.1
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.6	-1.0	-1.6	-0.0
Qualifications: None of the above	0.2	0.5	1.4	-1.2	-0.1	0.4
Financial difficulties in last 2 years	0.5	0.6	1.5	0.3	-0.5	1.2
Mouth/teeth dental problems	1.2	1.8	4.5	-0.3	2.1	1.0
Heart attack	0.3	0.4	0.9	0.4	-0.9	0.4
Allergy	0.5	1.1	2.8	-0.0	0.6	-1.7
Pain all over the body in last month	1.6	1.7	2.7	-1.5	-1.6	-0.4
Diabetes (self-reported)	1.1	1.7	3.4	-0.0	-1.9	-1.3
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	2.6	1.2	-1.6	-0.3
Medication: Ramipril	1.6	2.1	5.4	0.0	1.0	2.3
Medication: Simvastatin	1.2	1.8	3.4	0.6	-1.9	-1.2
Fluid intelligence score	0.1	0.3	0.8	0.0	0.9	-0.1
Illnesses of siblings	2.6	3.6	7.7	-0.2	2.8	1.8
Neuroticism score	0.1	0.2	0.5	0.1	0.7	-0.3
Weight	0.4	2.0	5.5	0.6	-2.3	0.1
Impedance of arm (right)	0.7	3.1	6.7	-2.6	-1.4	-0.7
Arm fat percentage (right)	1.4	5.6	15.4	-0.6	-3.9	-1.0
Trunk fat-free mass	0.3	1.8	3.1	1.8	-0.3	1.5
Hip circumference	0.8	3.3	8.7	-0.4	-3.0	-1.0
Time employed in main current job	0.5	0.6	1.5	-0.1	1.2	0.6
Alcohol intake versus 10 years previously	0.1	0.2	0.5	0.7	-0.4	-0.1
Father’s age at death	0.5	0.7	0.9	0.9	0.6	1.0
Worrier / anxious feelings	0.4	0.7	1.9	-0.6	1.4	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.9	1.4	-0.5	-0.6
Falls in the last year	0.5	0.7	1.7	0.5	0.2	-1.3
Hair/balding pattern: Pattern 3	0.9	1.3	3.0	-0.9	0.3	-1.7
Number of live births	0.1	0.2	0.5	-0.7	0.2	-0.3
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	3.0	-1.7	1.1	-0.8
Pulse rate	0.2	0.3	0.9	-1.0	-0.2	0.2
Happiness	0.6	0.8	1.4	-0.1	1.2	1.0
Noisy workplace	1.3	1.6	3.4	-1.8	-0.6	1.1
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.4	-1.2	0.9	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.1	0.9	0.9	-1.0
Mouth/teeth dental problems: Dentures	0.4	0.7	1.7	0.6	-1.3	0.2
Asthma	0.2	0.3	0.6	-0.5	-0.8	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	0.9	-0.9	-0.4	1.0
Medication: Cholesterol lowering	1.6	2.5	4.7	0.4	-2.2	-1.6
Depression (self-reported)	0.9	1.1	1.8	-1.4	1.3	0.1
Medication: Lansoprazole	0.8	0.9	1.6	-1.3	1.0	-0.3
Prospective memory result	0.1	0.1	0.2	-0.4	0.2	-0.5
Lung cancer (father)	0.7	0.8	1.8	1.4	0.8	-0.2
Illnesses of mother	0.3	0.3	1.0	-1.0	0.1	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	1.3	-1.1	1.1	-0.7
Pulse wave Arterial Stiffness index	0.5	0.6	1.3	-0.5	-1.1	0.4
Impedance of arm (left)	0.7	3.4	6.2	-2.5	-1.3	-1.5
Arm fat mass (right)	0.9	3.6	10.6	-0.2	-3.3	-0.3
Trunk predicted mass	0.3	2.0	3.1	1.8	-0.2	1.6
Standing height	0.1	0.6	0.9	1.0	0.3	0.9
Length of working week for main job	1.3	1.5	2.3	1.0	-1.0	1.5
Exposure to tobacco smoke at home	0.1	0.1	0.3	0.1	0.6	0.1
Breastfed as a baby	1.4	1.7	3.6	-0.2	1.9	1.2
Tense / ‘highly strung’	0.1	0.1	0.2	0.3	-0.5	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.8	2.2	-0.5	-1.5	-0.2
Hair/balding pattern: Pattern 4	0.9	2.2	4.5	-0.8	1.2	2.1
Birth weight of first child	0.7	1.2	1.9	-0.4	-1.2	1.4
Peak expiratory flow (PEF)	0.5	1.2	1.9	-1.3	1.4	0.1
Pulse wave reflection index	0.3	0.4	0.8	0.3	-0.9	-0.7
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.7	0.4	-0.6	1.6
Loud music exposure frequency	1.3	1.4	3.7	-0.3	0.6	1.9
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.9	-0.3	0.4	-0.9
Mouth/teeth dental problems: Bleeding gums	4.9	6.4	11.2	-2.0	-3.3	-2.0
Blood clot in the leg (DVT)	1.0	1.3	2.0	1.2	-1.4	0.6
Medication: Paracetamol	0.8	1.2	3.0	-0.8	-0.3	1.7
Headache pain in last month	0.7	1.2	2.8	1.7	0.4	0.9
Medication for cholesterol, blood pressure or diabetes	1.5	2.5	4.5	-0.3	1.7	2.1
Glaucoma (self-reported)	0.2	0.2	0.3	-0.5	-0.4	0.4
Gout (self-reported)	0.5	0.7	1.5	0.7	-0.4	-1.2
Hypothyroidism/myxoedema (self-reported)	3.0	5.9	17.3	-0.1	-4.2	-0.6
Medication: Amlodipine	1.2	1.7	2.6	-1.0	-1.2	-1.6
Medication: Ventolin 100micrograms inhaler	1.9	2.4	4.0	-1.0	-1.5	-2.0
Birth weight	0.9	1.9	4.2	-1.1	0.5	2.1
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.3	-0.2	0.6	0.5
High blood pressure (siblings)	2.1	3.0	5.5	0.5	-1.8	-2.3
Forced vital capacity (FVC), Best measure	0.4	1.4	3.3	-0.9	1.8	0.3
Body fat percentage	1.6	6.5	16.8	-0.7	-4.1	-1.5
Leg fat percentage (right)	1.0	3.8	10.5	-0.8	-3.2	-0.5
Arm fat-free mass (right)	0.2	1.2	2.9	1.7	-0.5	0.7
Exposure to tobacco smoke outside home	1.0	1.4	2.9	1.7	-0.3	1.1
Comparative body size at age 10	0.6	1.7	3.8	-0.2	-2.0	-1.1
Number of full brothers	0.8	1.0	2.3	0.3	-1.5	-0.9
Worry too long after embarrassment	1.9	3.2	8.1	-1.0	2.8	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.7	0.9	0.5	-0.2
Wheeze or whistling in the chest in last year	0.8	1.4	3.2	-0.2	-1.8	0.9
Number of children fathered	0.1	0.2	0.2	-0.5	0.4	0.3
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	3.3	-1.8	0.4	-0.1
Age at first live birth	1.0	1.7	4.8	-0.6	2.2	0.3
Pulse wave peak to peak time	0.5	0.6	1.5	0.5	1.2	-0.1
Health satisfaction	1.0	1.4	2.0	-1.2	-1.4	-0.8
Shortness of breath walking on level ground	0.2	0.2	0.4	-0.6	-0.2	-0.6
Qualifications: College or University degree	0.3	0.9	2.4	0.5	0.1	1.5
Eye problems/disorders: None of the above	1.1	1.2	1.5	1.1	1.2	1.0
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.5	-1.3	0.2	-1.6
Emphysema/chronic bronchitis	0.2	0.3	0.4	-0.6	-0.2	0.7
Medication for pain relief, constipation, heartburn	0.4	0.7	1.5	0.8	1.2	0.2
Neck or shoulder pain in last month	0.5	0.7	1.3	0.5	-0.7	-1.1
Medication: Blood pressure	0.5	0.9	2.3	0.4	-1.5	-0.5
Angina (self-reported)	1.6	2.1	6.0	0.2	-2.4	-0.4
Migraine (self-reported)	0.6	0.8	1.7	-1.3	-0.4	0.7
Medication: Ibuprofen	1.6	1.9	2.8	-1.6	0.3	1.7
Medication: Allopurinol	0.2	0.3	0.4	0.7	-0.6	0.2
Medication: Omeprazole	0.3	0.4	0.7	-0.6	-0.9	0.4
Medication: Seretide 50 evohaler	0.7	0.8	1.8	-0.7	-1.3	-0.2
Mean time to correctly identify matches	0.1	0.2	0.2	-0.5	-0.1	0.4
Heart disease (mother)	0.4	0.5	1.5	0.2	-1.2	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.6	-0.5	0.7	1.3
Whole body fat mass	1.0	4.3	12.5	-0.1	-3.5	-0.6
Leg fat mass (right)	0.7	2.9	8.5	-0.3	-2.9	0.1
Arm predicted mass (right)	0.3	1.5	3.1	1.8	-0.7	0.9
Pulse rate, automated reading	0.1	0.4	1.0	-1.0	0.3	0.2
Alcohol intake frequency.	0.1	0.3	1.0	0.0	1.0	0.0
Comparative height size at age 10	0.1	0.4	0.8	-0.3	-0.5	-0.9
Number of full sisters	0.9	1.1	2.5	-0.7	0.6	1.6
Suffer from ‘nerves’	0.5	0.8	1.7	0.4	-0.7	-1.3
Overall health rating	1.0	2.1	4.5	0.7	-2.1	-1.1
Chest pain or discomfort	1.8	2.5	5.7	2.4	-1.4	-0.0
Had major operations	0.5	0.6	1.2	0.7	0.2	1.1
Age at last live birth	1.2	1.7	2.9	-0.5	1.7	1.4
Family relationship satisfaction	0.9	1.1	1.8	1.2	0.2	1.4
Leg pain on walking	0.4	0.5	1.4	-0.1	0.2	1.2
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	3.9	-0.1	-2.0	0.7
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.0	1.4	-0.3	-0.3
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	-0.4	-0.3	0.2
Medication: Aspirin	1.6	2.1	3.8	0.2	-1.9	-1.6
Supplements: Vitamin C	0.3	0.3	0.9	1.0	-0.0	-0.0
Knee pain experienced in last month	0.1	0.1	0.2	-0.2	0.5	0.2
Hypertension (Self-reported)	0.6	1.5	2.4	0.8	-1.6	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.2	-1.2	1.5	0.5
Illnesses of father: Heart disease	1.7	2.4	3.5	-1.9	-1.0	-1.6
Illnesses of siblings: Diabetes	1.3	1.6	2.3	-1.5	-1.5	0.2
Smoking status: Previous	0.7	1.0	2.9	-0.2	-0.2	1.7
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	4.9	2.2	-1.1	-0.0
Whole body fat-free mass	0.3	1.5	2.5	1.6	-0.4	1.4
Leg fat-free mass (right)	0.2	1.0	1.6	1.3	-0.2	1.2
Arm fat percentage (left)	1.5	5.9	15.3	-0.6	-3.9	-1.4
Average weekly red wine intake	1.3	1.9	5.1	-0.7	2.3	0.4
Handedness (chirality/laterality): Left-handed	1.1	1.4	2.4	-1.5	0.1	1.3
Mood swings	0.0	0.1	0.2	0.2	-0.0	0.4
Loneliness, isolation	0.7	1.0	1.7	-0.3	1.3	1.1
Long-standing illness, disability or infirmity	0.8	1.3	3.0	0.5	-1.7	-0.7
Ever had bowel cancer screening	1.1	1.3	2.2	0.8	1.1	1.5
Diabetes diagnosed by doctor	0.6	1.0	2.3	0.0	-1.5	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	1.6	-0.2	-1.3	-1.0
Friendships satisfaction	3.1	3.9	8.7	0.4	1.7	3.0
Qualifications: nursing, teaching	0.6	0.9	1.7	-0.7	1.3	0.8
Commuting to job workplace: Walk	0.1	0.1	0.1	-0.4	-0.3	-0.3
Eye problems/disorders: Cataract	2.5	2.9	4.0	-1.8	-1.2	-2.0
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.4	-0.7	1.2	0.1
Medication for cholesterol	0.7	1.1	2.2	0.9	-0.3	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.8	4.1	-0.5	-2.0	-1.0
Back pain experienced in last month	2.2	3.2	9.2	3.0	0.5	0.3
Mineral and other dietary supplements	1.9	2.5	4.9	0.7	-1.4	-2.2
Breast cancer (self-reported)	0.2	0.2	0.4	-0.4	0.6	0.0
Asthma (self-reported)	0.2	0.4	1.0	-0.4	-1.0	-0.1
Osteoporosis (self-reported)	3.7	4.6	9.8	-3.1	1.8	-0.9
Osteoarthritis (self-reported)	0.3	0.3	0.7	0.2	0.6	0.8
Medication: Aspirin	2.3	3.0	4.5	0.8	-2.1	-1.9
Medication: Gliclazide	0.0	0.0	0.1	-0.2	-0.1	-0.3
Illnesses of father: None of the above (group 1)	0.6	0.7	2.0	0.1	-0.5	1.4
Smoking status: Current	0.6	1.0	2.7	0.5	-1.6	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.2	5.1	-0.7	2.3	-1.0
Whole body water mass	0.3	1.6	2.6	1.6	-0.3	1.4
Leg predicted mass (right)	0.2	1.1	1.7	1.3	-0.2	1.2
Arm fat mass (left)	0.9	3.5	10.1	-0.1	-3.2	-0.7
Number of self-reported non-cancer illnesses	1.3	2.3	6.6	-0.4	-2.6	-0.4
Average weekly champagne plus white wine intake	0.8	1.1	3.3	-1.8	-0.2	0.1
Miserableness	0.3	0.5	1.1	-1.1	-0.5	0.3
Guilty feelings	0.1	0.1	0.2	-0.1	-0.5	-0.4
Wears glasses or contact lenses	0.8	1.0	1.9	-1.4	-0.5	0.8
Ever taken oral contraceptive pill	0.3	0.4	0.8	0.9	0.5	0.0
Hearing aid user	0.5	0.6	0.6	-0.7	0.8	0.8
Mother’s age at death	0.2	0.3	0.5	0.7	-0.2	0.6
Financial situation satisfaction	0.3	0.4	1.0	0.1	-1.0	0.4
Tinnitus: Yes, now most or all of the time	0.6	0.8	1.4	-0.9	0.2	1.2
Commuting to job workplace: Public transport	1.7	2.1	5.2	-2.3	-0.3	-1.0
Eye problems/disorders: Glaucoma	0.6	0.7	2.2	-0.2	-1.5	0.1
Medication: Blood pressure	0.1	0.1	0.2	-0.1	0.4	-0.4
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	0.3	-0.1	0.5
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.1	-1.1	1.4	0.7
High cholesterol (Self-reported)	1.0	1.8	2.9	0.4	-1.7	-1.5
Medication: Bendroflumethiazide	0.6	0.9	2.2	0.7	-1.5	-0.3
Medication: Paracetamol	1.3	2.0	4.4	-1.2	0.6	2.1
Medication: Lisinopril	2.8	3.7	5.8	-0.9	-2.4	-2.1
Medication: Atorvastatin	2.3	2.8	7.1	-0.2	-2.7	-1.2
Illnesses of father: High blood pressure	1.4	1.7	3.6	1.1	1.9	0.5
Alcohol drinker status: Never	2.6	3.2	9.2	-0.5	-3.0	-0.3
Ever smoked	0.3	0.5	1.2	0.2	-0.6	1.1
Basal metabolic rate	0.2	1.3	1.9	1.4	-0.8	1.1
Leg fat percentage (left)	1.0	3.8	10.6	-0.6	-3.2	-0.6
Arm fat-free mass (left)	0.3	1.6	3.0	1.7	-0.5	1.2
Number of operations (self-reported)	0.7	1.1	1.7	1.3	-1.3	0.1
Average weekly beer plus cider intake	1.1	1.5	2.4	-0.9	-1.2	-1.5
Irritability	0.1	0.2	0.5	-0.0	-0.7	-0.4
Risk taking	1.3	2.0	2.9	0.7	-1.7	1.6
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.3	-0.3	0.7	-1.5
Fractured/broken bones in last 5 years	0.7	0.9	1.4	-1.0	0.2	-1.2
Age started oral contraceptive pill	0.1	0.2	0.4	-0.1	-0.3	0.6
Diastolic blood pressure, automated reading	0.1	0.5	1.2	1.1	-0.4	0.1
Ever depressed for a whole week	0.8	1.0	1.9	-1.4	-1.0	0.3
Unable to work because of sickness or disability	0.2	0.2	0.5	-0.3	-0.7	-0.2
Commuting to job workplace: Cycle	1.0	1.3	3.6	-1.9	0.3	-0.2
Myopia	0.8	1.2	2.3	-1.5	0.7	0.9
Vascular/heart problems diagnosed by doctor	0.6	1.8	3.2	-0.9	1.8	1.1
Cholesterol lowering medication	0.1	0.1	0.1	-0.4	-0.3	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.1	0.1	-1.4	-0.6
Pain experienced in last month	1.2	2.1	4.4	-2.1	1.1	0.8
Supplements: Calcium	2.0	2.2	4.3	-1.1	1.1	2.1
Basal cell carcinoma (self-reported)	1.8	2.2	5.0	-2.2	-0.3	-1.2
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.8	0.3	-1.3	0.2
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	1.5	1.2	-1.1	0.5
Heart disease (siblings)	2.5	3.0	6.8	-0.2	-2.6	-1.5
Alcohol drinker status: Previous	0.5	0.5	1.0	-1.0	0.8	0.3
Pack years of smoking	0.3	0.5	0.6	-0.8	-0.8	0.5
Impedance of whole body	0.6	2.9	4.9	-2.2	-1.1	-1.7
Leg fat mass (left)	0.8	3.0	9.0	-0.2	-3.0	0.0
Arm predicted mass (left)	0.2	1.1	1.7	1.3	-0.8	1.1