TWAS hub - ZNF608

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.202	0.0570	1.5e-04	0.028	NA	0.047	NA	0.029	3.5e-03	NA	1.9e-04	NA	2.7e-03
2	GTEx	Esophagus Mucosa	0.194	0.0670	2.2e-03	0.116	NA	0.094	NA	0.119	3.7e-08	NA	7.9e-07	NA	2.6e-08
3	ROSMAP	Brain Pre-frontal Cortex	0.103	0.0274	2.2e-05	0.040	0.051	0.040	0.048	0.038	6.2e-06	3.7e-07	7.0e-06	6.8e-07	1.1e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Heel bone mineral density (BMD) T-score, automated (left)	5.0	11.4	26.2	1.9	2.0	-5.1
Body Mass Index (BMI) (2010)	4.7	6.4	10.3	1.5	-2.6	3.2
HbA1C	4.7	5.3	12.3	0.3	-1.9	-3.5
Age at last live birth	4.5	6.5	12.6	0.5	-2.6	-3.5
Ever taken oral contraceptive pill	3.9	4.3	7.6	2.2	-2.8	0.6
Age started oral contraceptive pill	3.6	4.5	7.1	-2.5	0.5	-2.7
Age at first live birth	3.1	5.5	10.6	-1.0	-2.2	-3.3
Supplements: Glucosamine	3.0	3.9	7.4	-1.9	2.7	0.9
Overall health rating	3.0	6.3	18.7	0.2	0.5	4.3
Hearing difficulty/problems: Yes	2.9	4.4	10.5	0.9	-1.4	3.2
Tinnitus: Yes, but not now, but have in the past	2.7	2.9	6.3	1.4	-0.6	2.5
BMI	2.6	15.1	38.8	1.9	-1.7	6.2
Supplements: Zinc	2.6	2.8	7.0	-0.4	-1.1	2.6
Medication: Ibuprofen	2.6	3.2	5.3	-2.0	2.3	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	2.5	5.7	13.9	1.4	1.1	-3.7
Noisy workplace	2.5	3.1	9.4	-0.1	3.1	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	2.4	3.2	4.6	0.6	2.1	2.1
Worrier / anxious feelings	2.4	4.6	7.9	-1.7	2.8	-1.8
Leg fat mass (left)	2.4	9.2	24.5	1.8	-0.1	5.0
Fractured/broken bones in last 5 years	2.3	3.0	7.9	-2.8	0.7	0.7
Townsend deprivation index at recruitment	2.2	3.1	5.2	-1.2	1.7	2.3
Leg fat mass (right)	2.2	8.7	23.5	1.6	-0.3	4.8
Other serious medical condition/disability diagnosed by doctor	2.1	2.7	4.7	1.4	2.2	-1.2
Time employed in main current job	2.1	2.5	6.0	-1.2	-2.4	0.1
Pulse wave reflection index	2.1	2.6	7.7	0.1	-0.2	-2.8
Leg pain on walking	2.1	2.6	3.3	-1.8	1.6	-1.4
Handedness (chirality/laterality): Left-handed	2.1	2.6	4.7	0.4	-2.2	1.7
Eye problems/disorders: Cataract	2.1	2.4	6.3	-2.5	-0.9	-0.5
Unable to work because of sickness or disability	2.1	2.7	5.0	-1.5	-1.0	2.2
Alzheimer’s Disease (in father)	2.0	2.1	5.9	2.4	-0.1	0.7
Bipolar Disorder (2011)	2.0	1.9	3.7	-0.6	1.9	-1.3
Financial difficulties in last 2 years	2.0	2.7	5.4	1.6	2.3	0.3
Whole body fat mass	2.0	8.6	23.6	1.4	-0.0	4.9
Ever depressed for a whole week	2.0	2.5	6.1	-0.2	2.5	-1.2
Major Depression (MDD)	1.9	2.4	2.9	-1.7	1.3	-1.5
Frequency of depressed mood in last 2 weeks	1.9	2.6	3.3	1.6	1.8	1.4
Body mass index (BMI)	1.9	8.2	20.6	1.7	-0.9	4.5
Trunk fat mass	1.9	8.1	22.5	1.3	0.1	4.7
Hearing difficulty/problems with background noise	1.9	3.1	9.2	0.1	-0.2	3.0
Ever unenthusiastic/disinterested for a whole week	1.9	2.3	5.3	-0.6	2.3	-1.1
Weight	1.9	9.3	24.6	1.8	0.2	5.0
Arm fat mass (right)	1.9	7.8	22.1	1.2	-0.1	4.7
Medication: Aspirin	1.9	2.5	6.8	2.6	-0.7	0.6
Arm fat mass (left)	1.9	7.7	21.3	1.3	-0.0	4.6
Mother’s age at death	1.9	2.4	6.7	-2.6	0.7	0.1
Medication: Lisinopril	1.9	2.5	5.8	-1.2	0.3	-2.4
Rheumatoid Arthritis	1.8	2.5	7.1	0.6	0.1	2.7
Serious illness, injury or assault to yourself	1.8	2.2	3.9	-0.9	2.0	-1.4
Waist circumference	1.8	6.7	19.5	0.8	0.1	4.4
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	3.7	-1.7	1.9	-0.5
Lung cancer (father)	1.8	2.1	6.1	0.2	-0.5	-2.5
Medication: Aspirin	1.8	2.4	6.3	2.5	-0.6	0.8
Mean Putamen Volume	1.7	1.9	3.0	1.6	-0.3	-1.7
Hip circumference	1.7	7.1	17.6	1.9	-0.5	4.2
Loud music exposure frequency	1.7	1.8	5.4	0.4	-0.1	2.3
Arm predicted mass (right)	1.7	8.9	20.4	2.5	0.6	4.5
Leg fat-free mass (left)	1.6	8.3	21.3	1.9	0.5	4.6
Stomach or abdominal pain in last month	1.6	2.0	4.4	0.4	1.3	2.1
Leg predicted mass (left)	1.6	8.4	21.7	1.8	0.4	4.7
Number of full brothers	1.6	2.0	5.9	-0.3	-0.0	2.4
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.8	4.4	-0.9	-0.4	-2.1
Mouth/teeth dental problems: Loose teeth	1.6	1.9	2.2	1.5	-1.4	1.2
Average weekly red wine intake	1.6	2.4	6.4	0.9	-0.0	-2.5
Trunk fat percentage	1.5	5.8	16.7	0.9	0.0	4.1
Mouth/teeth dental problems	1.5	2.3	5.2	-0.9	1.0	-2.3
Happiness	1.5	1.8	4.1	0.8	2.0	-0.8
Exposure to tobacco smoke at home	1.5	1.7	4.9	-0.3	0.2	2.2
Medication: Ventolin 100micrograms inhaler	1.5	2.0	4.2	1.3	-0.3	-2.0
Body fat percentage	1.5	5.9	16.6	1.0	-0.3	4.1
Leg fat percentage (right)	1.5	5.3	14.1	1.1	-0.8	3.8
Leg fat-free mass (right)	1.5	7.8	19.1	1.9	0.7	4.4
Qualifications: nursing, teaching	1.5	2.4	3.4	1.8	-1.8	-0.8
Basal metabolic rate	1.5	8.4	20.6	2.1	0.4	4.5
Leg fat percentage (left)	1.5	5.6	14.9	1.3	-0.5	3.9
Depression (Nagel 2018)	1.4	2.1	4.0	0.4	2.0	1.4
Chronotype (morning person)	1.4	3.2	8.7	0.9	0.1	-3.0
Sensitivity / hurt feelings	1.4	2.3	5.3	-1.3	2.3	0.1
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.1	2.8	0.9	1.7	1.7
Arm fat percentage (right)	1.4	5.5	15.7	0.8	-0.4	4.0
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.2	5.3	-0.1	2.3	1.1
Arm fat-free mass (right)	1.4	7.4	16.7	2.3	0.6	4.1
Alcohol intake frequency.	1.4	3.3	9.2	-0.5	-0.5	3.0
Smoking status: Previous	1.4	2.1	4.8	0.4	-2.2	1.1
Friendships satisfaction	1.4	1.7	4.1	0.7	2.0	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	2.4	-1.6	1.2	0.9
Leg predicted mass (right)	1.4	7.7	19.2	1.8	0.7	4.4
Supplements: Fish oil (including cod liver oil)	1.4	1.8	3.8	-0.1	1.9	1.3
Arm fat-free mass (left)	1.4	7.4	17.8	2.0	0.5	4.2
Alcohol drinker status: Previous	1.4	1.6	3.8	-0.8	-0.7	1.9
Arm predicted mass (left)	1.4	7.3	16.6	2.2	0.4	4.1
Alzheimer’s Disease (including proxy)	1.3	1.9	2.2	1.4	1.5	1.3
Fasting Glucose	1.3	1.5	3.4	-0.7	-0.8	1.8
Heel T-Score	1.3	10.3	21.9	1.6	4.7	-2.5
Lung FEV1/FVC ratio	1.3	6.6	12.8	2.0	-3.6	1.7
Medication: Lansoprazole	1.3	1.4	3.5	0.2	0.8	1.9
Prospective memory result	1.3	1.6	2.6	1.6	0.2	-1.4
Whole body fat-free mass	1.3	7.5	17.9	2.1	0.5	4.2
Arm fat percentage (left)	1.3	5.1	14.7	0.8	-0.2	3.8
Illnesses of father: None of the above (group 1)	1.3	1.7	3.0	-1.7	1.4	-0.2
Smoking status: Current	1.3	2.1	2.8	1.5	1.7	1.0
Whole body water mass	1.3	7.5	17.7	2.1	0.6	4.2
Tinnitus: Yes, now most or all of the time	1.3	1.6	2.6	1.6	-1.2	-0.8
Illnesses of father: High blood pressure	1.3	1.6	2.7	1.3	-1.6	-0.6
Neuroticism (2016)	1.2	1.8	4.5	0.0	2.1	-1.0
Waist Hip Ratio (WHR)	1.2	5.3	11.6	-3.4	2.1	0.2
Ever used hormone-replacement therapy (HRT)	1.2	1.5	2.3	1.3	1.5	-0.7
Hand grip strength (right)	1.2	3.3	7.6	2.8	-1.5	-0.3
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	3.2	1.8	1.3	-0.2
Medication: Cholesterol lowering	1.2	1.9	4.6	2.1	0.0	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.5	2.6	0.9	0.9	-1.6
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	3.7	-0.9	-1.9	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	1.4	1.2	1.2	1.1
Hand grip strength (left)	1.1	3.0	5.0	2.2	-2.0	-0.2
Diabetes (mother)	1.1	1.4	3.3	-0.3	-1.8	0.9
Pain all over the body in last month	1.1	1.2	3.1	0.5	-1.8	-0.3
Impedance of arm (right)	1.1	5.2	10.4	-2.2	0.4	-3.2
Trunk fat-free mass	1.1	6.3	14.2	2.1	0.5	3.8
Exposure to tobacco smoke outside home	1.1	1.5	3.3	1.0	1.8	0.6
Emphysema/chronic bronchitis	1.1	1.2	2.2	-0.8	1.5	-0.9
Mood swings	1.1	1.9	4.1	1.2	2.0	-0.4
Pack years of smoking	1.1	1.7	2.9	-1.7	0.8	1.2
Alzheimer’s Disease (in mother)	1.0	1.2	3.5	-0.1	1.9	0.3
Ulcerative Colitis	1.0	1.4	3.0	-1.7	1.1	-0.5
Medication for hormone replacement therapy	1.0	1.2	2.5	1.6	0.0	-1.0
Medication: Co-codamol	1.0	1.2	1.4	-1.2	-1.1	1.0
Current tobacco smoking	1.0	1.6	2.0	1.4	1.0	1.4
Had other major operations	1.0	1.2	3.2	1.8	0.3	-0.6
Mouth/teeth dental problems: Dentures	1.0	1.7	3.0	1.2	0.8	1.7
Impedance of arm (left)	1.0	4.4	7.4	-2.3	0.8	-2.7
Trunk predicted mass	1.0	6.0	13.5	2.0	0.5	3.7
Number of full sisters	1.0	1.2	3.3	-0.3	-0.5	1.8
Had major operations	1.0	1.2	2.3	-1.1	0.3	-1.5
Miserableness	1.0	1.8	3.3	1.8	0.8	-1.2
Schizophrenia (2018)	0.9	1.8	2.7	-1.6	1.6	0.0
Verbal and Numeric Reasoning (VNR)	0.9	2.2	5.2	1.1	0.5	-2.3
Coronary Artery Disease (CAD)	0.9	1.1	1.9	1.2	-0.0	1.4
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.7	0.4	0.2	1.6
Pack years adult smoking proportion	0.9	1.3	2.5	-1.6	0.4	1.2
Allergy	0.9	2.1	3.0	-1.7	-0.8	-1.7
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	5.0	2.2	0.7	-0.1
Birth weight	0.9	1.9	3.9	-0.8	1.2	2.0
Worry too long after embarrassment	0.9	1.5	3.8	-0.3	0.9	-1.9
Medication: Omeprazole	0.9	1.1	1.7	-1.3	1.2	0.1
Mean time to correctly identify matches	0.9	1.6	3.5	1.9	1.0	0.6
Ever had bowel cancer screening	0.9	1.0	1.2	-1.0	1.1	-1.0
Osteoarthritis (self-reported)	0.9	1.2	2.2	-1.5	0.6	0.9
Average weekly beer plus cider intake	0.9	1.3	2.0	-1.1	-0.9	1.4
Bipolar Disorder or Schizophrenia	0.8	2.0	3.4	-1.6	1.8	-0.6
Reaction Time	0.8	1.4	2.7	1.1	1.6	0.5
Ovarian Cancer	0.8	1.1	3.0	-1.7	0.5	-0.3
Age at First Birth	0.8	1.2	3.5	-1.9	-0.3	0.3
Hypothyroidism (self reported)	0.8	1.8	4.2	2.0	0.7	0.9
Vitamin and mineral supplements	0.8	1.1	2.2	-1.1	-1.5	0.2
Medication: Metformin	0.8	1.1	2.5	1.6	-0.1	0.9
Age when periods started (menarche)	0.8	2.0	4.9	0.4	-2.2	-1.0
Chronic bronchitis/emphysema (father)	0.8	0.9	1.5	-1.2	-1.2	0.0
Number of incorrect matches in round	0.8	1.4	1.9	1.4	1.4	-0.6
Nervous feelings	0.8	1.5	3.8	-1.9	0.3	0.8
Hair/balding pattern: Pattern 2	0.8	1.0	2.7	-1.6	0.5	0.3
Hair/balding pattern: Pattern 3	0.8	1.2	3.4	1.8	-0.2	-0.5
Number of live births	0.8	1.2	2.7	-0.2	-0.9	1.6
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	2.6	1.6	0.0	0.5
Asthma	0.8	1.5	2.8	1.7	-0.1	1.4
Peak expiratory flow (PEF)	0.8	1.8	3.4	1.4	-1.8	-0.1
Health satisfaction	0.8	1.1	2.8	-0.7	1.7	0.1
Eye problems/disorders: None of the above	0.8	1.0	1.3	1.1	0.5	1.1
Family relationship satisfaction	0.8	1.0	1.8	0.2	1.1	-1.3
Breast cancer (self-reported)	0.8	0.9	1.6	-0.9	0.6	-1.3
Financial situation satisfaction	0.8	1.0	1.1	1.0	1.0	1.0
Eye problems/disorders: Glaucoma	0.8	0.9	2.0	-0.4	0.7	-1.4
Medication: Atorvastatin	0.8	1.0	1.5	1.1	1.2	0.4
Cholesterol lowering medication	0.8	1.2	3.1	1.8	0.7	-0.4
Impedance of whole body	0.8	4.1	7.5	-2.2	0.4	-2.7
Lupus	0.7	1.0	1.9	0.4	-1.0	-1.4
Schizophrenia (2014)	0.7	1.5	2.8	-1.1	1.7	-0.7
Blood White Count	0.7	4.9	12.4	1.0	-1.2	3.5
Respiratory disease	0.7	1.5	2.5	1.4	0.1	1.6
Type 2 Diabetes (T2D) (2018)	0.7	1.3	2.8	1.7	0.4	0.9
Neuroticism	0.7	1.6	2.7	-0.7	1.6	-1.2
Angina	0.7	0.9	1.4	1.2	-1.1	-0.3
Maternal smoking around birth	0.7	1.1	1.6	-0.9	1.3	0.9
Medication: Atenolol	0.7	0.9	1.6	0.2	1.0	1.3
Neuroticism score	0.7	1.4	3.2	-0.7	1.8	-0.7
Birth weight of first child	0.7	1.2	2.5	-1.6	0.9	-0.6
Headache pain in last month	0.7	1.2	2.3	0.3	1.5	1.0
Wheeze or whistling in the chest in last year	0.7	1.2	3.3	0.7	0.2	1.8
Qualifications: College or University degree	0.7	2.1	6.0	0.6	0.1	-2.4
Medication: Allopurinol	0.7	0.9	1.7	-0.2	0.9	-1.3
Supplements: Vitamin C	0.7	0.8	1.2	-1.0	1.1	0.4
Knee pain experienced in last month	0.7	1.0	2.6	-1.6	0.5	0.4
Illnesses of father: Heart disease	0.7	0.9	2.1	1.5	-0.8	0.1
Medication for cholesterol	0.7	1.1	2.7	-0.7	-1.6	0.1
Hearing aid user	0.7	0.8	2.1	0.0	-0.6	1.4
Myopia	0.7	1.1	2.6	-1.6	0.0	0.8
Intelligence (Savage-Jansen 2018)	0.6	1.8	4.4	0.7	0.7	-2.1
Schizophrenia vs Biploar Disorder	0.6	0.9	2.0	1.4	-0.6	-0.5
Worry (Nagel 2018)	0.6	1.3	1.4	-1.1	1.1	-1.2
Crohns Disease (2012)	0.6	0.9	2.3	0.6	1.5	-0.0
Relative age of first facial hair	0.6	1.3	2.5	-0.0	-1.6	1.1
Severe depression (siblings)	0.6	0.6	1.1	-0.3	-1.0	0.9
Medication: Simvastatin	0.6	0.8	2.5	1.6	-0.0	-0.1
Angina (self-reported)	0.6	0.8	1.3	1.0	-1.1	-0.3
Heart disease (mother)	0.6	0.8	1.0	1.0	-0.6	-1.0
Commuting to job workplace: Public transport	0.6	0.7	1.3	-1.2	-0.7	0.5
Alcohol drinker status: Never	0.6	0.7	1.7	1.3	-0.2	0.7
Risk taking	0.6	0.8	1.5	0.2	-1.2	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.2	-0.6	1.1	0.8
Supplements: Calcium	0.6	0.7	1.4	-0.6	-1.2	0.6
Crohns Disease (2017)	0.5	1.0	1.7	0.6	0.9	1.3
Prostate Cancer	0.5	0.7	1.1	-1.0	-0.8	-0.7
Smoking Status	0.5	1.2	2.7	1.6	-0.6	0.8
Allergy or Eczema	0.5	1.2	1.6	1.3	1.0	1.1
Impedance of leg (right)	0.5	2.4	5.6	-1.2	-0.3	-2.4
Average weekly fortified wine intake	0.5	0.6	1.2	0.8	-0.4	-1.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.2	1.1	-0.7	-0.3
Qualifications: CSEs or equivalent	0.5	0.7	1.9	0.0	0.2	1.4
Medication: Levothyroxine sodium	0.5	0.8	1.3	1.1	0.8	0.7
Sitting height	0.5	3.3	7.1	0.6	2.7	1.5
Impedance of leg (left)	0.5	2.3	5.6	-1.2	0.1	-2.4
Past tobacco smoking	0.5	1.0	1.3	-0.7	1.0	-1.1
Had menopause	0.5	0.6	1.0	-0.8	0.3	-1.0
Pulse rate	0.5	0.8	2.4	-0.1	0.1	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	4.5	0.2	-0.2	2.1
Length of working week for main job	0.5	0.6	1.4	-1.2	0.3	-0.6
Breastfed as a baby	0.5	0.6	1.0	0.4	-1.0	-0.8
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.9	-0.3	-0.2	1.4
Medication: Paracetamol	0.5	0.9	2.4	-0.4	0.3	-1.5
Gout (self-reported)	0.5	0.7	1.5	-1.2	0.5	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	0.9	-0.9	0.5	0.9
Migraine (self-reported)	0.5	0.6	1.4	-1.2	0.3	-0.7
Illnesses of siblings: Diabetes	0.5	0.6	1.0	-0.6	-0.6	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.3	-0.7	-0.5	1.5
Loneliness, isolation	0.5	0.7	1.9	-0.4	1.4	0.4
Long-standing illness, disability or infirmity	0.5	0.7	1.5	0.3	1.2	0.7
Asthma (self-reported)	0.5	1.1	2.3	1.5	-0.3	0.9
Osteoporosis (self-reported)	0.5	0.7	1.9	-0.1	-0.3	-1.4
Guilty feelings	0.5	0.8	1.6	-0.4	1.2	-0.8
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.6	-1.3	-0.4	-0.3
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.0	0.8	-1.0	0.4
Bipolar Disorder (2018)	0.4	0.6	0.8	-0.5	0.9	-0.9
Neuroticism (Nagel 2018)	0.4	0.9	1.4	-0.1	1.1	-1.2
Irritable Bowel Disease (IBD)	0.4	0.9	2.2	0.1	0.8	1.5
LDL Cholesterol	0.4	0.7	1.5	0.6	1.2	0.3
Blood Eosinophil Count	0.4	2.7	7.1	0.8	-2.7	-0.5
Height	0.4	7.2	10.9	-0.4	3.3	3.3
Number of treatments/medications taken	0.4	0.7	2.0	1.4	0.1	-0.2
Average weekly spirits intake	0.4	0.4	0.9	0.9	0.6	-0.3
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.9	1.4	0.5	0.6
Alcohol usually taken with meals	0.4	0.6	1.1	1.0	0.4	-0.7
Medication: Ramipril	0.4	0.5	0.7	-0.8	-0.6	-0.7
Falls in the last year	0.4	0.6	1.5	-0.1	-0.4	1.2
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.1	0.5	-0.6	-1.4
Illnesses of mother	0.4	0.5	1.4	-0.5	1.2	0.1
Tense / ‘highly strung’	0.4	0.6	1.4	-0.3	0.6	-1.2
Hair/balding pattern: Pattern 4	0.4	0.9	1.8	0.8	0.2	1.3
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.6	-0.2	0.6	1.3
Medication for pain relief, constipation, heartburn	0.4	0.7	1.7	-1.3	-0.0	0.7
Comparative height size at age 10	0.4	2.5	6.9	-0.2	0.7	2.6
Chest pain or discomfort	0.4	0.5	0.8	0.7	0.9	0.5
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.1	-0.5	-1.0	0.7
Back pain experienced in last month	0.4	0.6	1.3	-0.5	0.4	1.1
Mineral and other dietary supplements	0.4	0.5	0.9	0.9	-0.9	0.1
Commuting to job workplace: Cycle	0.4	0.5	1.0	0.7	1.0	-0.4
Pain experienced in last month	0.4	0.7	1.1	1.0	-1.1	0.3
Heart disease (siblings)	0.4	0.4	0.9	0.3	-0.6	-0.9
Ulcerative Colitis (UC)	0.3	0.6	1.4	-0.6	0.4	1.2
Breast Cancer	0.3	0.7	1.7	0.4	-1.3	-0.3
HDL Cholesterol	0.3	0.5	0.8	-0.5	0.6	-0.9
Primary Biliary Cirrhosis	0.3	0.5	1.3	-0.3	-1.1	0.1
Triglycerides	0.3	0.4	0.7	0.8	-0.4	0.7
Systolic blood pressure, automated reading	0.3	0.9	2.1	-0.2	0.8	1.4
Diabetes (father)	0.3	0.4	1.1	-0.0	1.0	-0.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.0	-1.0	0.0	-0.5
Heart attack	0.3	0.4	1.1	0.4	-1.0	0.1
Alcohol intake versus 10 years previously	0.3	0.4	0.7	-0.8	-0.0	0.8
Depression (self-reported)	0.3	0.3	0.5	-0.4	0.7	0.7
Standing height	0.3	2.6	4.3	0.4	2.1	1.8
Medication: Amlodipine	0.3	0.4	0.8	0.9	-0.2	-0.6
Forced vital capacity (FVC), Best measure	0.3	1.0	2.2	-0.3	0.8	1.5
Diabetes diagnosed by doctor	0.3	0.6	1.6	1.3	-0.1	0.3
Medication: Gliclazide	0.3	0.4	0.5	0.5	0.7	-0.6
Wears glasses or contact lenses	0.3	0.4	0.9	0.3	0.4	1.0
Medication: Blood pressure	0.3	0.6	1.5	-0.2	1.2	-0.4
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.9	-0.1	0.4	0.9
High cholesterol (Self-reported)	0.3	0.6	1.5	1.2	-0.4	0.1
Number of operations (self-reported)	0.3	0.4	0.5	0.7	-0.7	-0.4
Diastolic blood pressure, automated reading	0.3	0.8	2.0	-0.0	-0.7	1.4
Depressed Affect (Nagel 2018)	0.2	0.3	0.5	0.3	0.7	-0.7
Systolic Blood Pressure	0.2	0.9	2.0	-1.4	0.9	-0.2
Cardiovascular Disease	0.2	0.7	2.0	0.2	-0.2	1.4
Ever had hysterectomy (womb removed)	0.2	0.2	0.3	-0.5	-0.3	0.5
Fed-up feelings	0.2	0.3	0.9	0.1	0.9	0.3
Taking other prescription medications	0.2	0.3	0.8	-0.0	-0.9	-0.0
High blood pressure	0.2	0.7	1.3	-1.2	0.7	0.5
Multivitamins +/- minerals	0.2	0.2	0.4	0.4	0.6	0.3
Qualifications: None of the above	0.2	0.5	1.3	-0.2	0.1	1.2
Diabetes (self-reported)	0.2	0.2	0.7	0.9	0.0	-0.1
Father’s age at death	0.2	0.3	0.6	-0.4	-0.4	0.8
Pulse wave Arterial Stiffness index	0.2	0.3	0.8	0.0	-0.9	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.6	-0.8	0.4	-0.4
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.4	0.6	0.4	0.6
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.2	-1.1	0.1	0.1
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.6	0.8	-0.3	0.2
High blood pressure (siblings)	0.2	0.3	0.4	-0.5	-0.6	0.6
Number of children fathered	0.2	0.2	0.4	0.4	-0.0	0.6
Shortness of breath walking on level ground	0.2	0.2	0.4	-0.2	-0.4	0.6
Neck or shoulder pain in last month	0.2	0.3	0.7	0.5	-0.1	0.9
Pulse rate, automated reading	0.2	0.5	1.5	0.1	1.2	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.5	0.1	0.6	0.7
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.5	0.2	0.7	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.5	0.5	-0.7	-0.6
Number of self-reported non-cancer illnesses	0.2	0.4	1.0	0.3	0.2	1.0
Medication: Bendroflumethiazide	0.2	0.3	0.5	-0.6	0.7	-0.2
Basal cell carcinoma (self-reported)	0.2	0.3	0.4	0.5	0.3	-0.6
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	0.1	-0.3	-0.5
Blood Platelet Count	0.1	0.7	1.9	1.4	-0.4	-0.1
Blood Red Count	0.1	0.6	1.7	-1.3	-0.1	0.4
Lung FVC	0.1	0.5	1.2	-1.1	-0.3	-0.3
Hair Pigment	0.1	1.8	3.2	-1.5	0.4	-1.8
Relative age voice broke	0.1	0.2	0.4	-0.7	-0.3	-0.2
Illnesses of siblings	0.1	0.1	0.1	-0.2	0.3	-0.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	0.6	0.1	-0.8	0.7
Glaucoma (self-reported)	0.1	0.1	0.3	-0.6	-0.2	0.2
Pulse wave peak to peak time	0.1	0.2	0.5	0.2	0.7	0.1
Medication: Blood pressure	0.1	0.2	0.6	-0.8	-0.0	-0.1
Medication: Seretide 50 evohaler	0.1	0.1	0.1	-0.4	0.1	0.3
Suffer from ‘nerves’	0.1	0.1	0.2	0.4	-0.2	-0.3
Hypertension (Self-reported)	0.1	0.4	1.1	-1.0	0.3	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	0.2	-0.4	0.2
Average weekly champagne plus white wine intake	0.1	0.2	0.5	-0.2	-0.7	-0.2
Medication: Paracetamol	0.1	0.1	0.2	0.3	-0.2	-0.4
Ever smoked	0.1	0.1	0.2	0.5	-0.4	0.1
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.4	0.5	0.3	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.4	0.1	0.6	0.1
Tanning	0.0	0.6	1.5	-0.4	-0.4	-1.2
High blood pressure (mother)	0.0	0.0	0.0	-0.1	-0.2	-0.1
Forced vital capacity (FVC)	0.0	0.1	0.2	-0.2	0.4	0.4
Fluid intelligence score	0.0	0.1	0.1	0.2	0.4	0.3
Blood clot in the leg (DVT)	0.0	0.0	0.1	0.0	0.4	0.1
Comparative body size at age 10	0.0	0.1	0.2	0.4	0.2	0.1
Commuting to job workplace: Walk	0.0	0.0	0.0	-0.2	0.0	-0.0
Irritability	0.0	0.0	0.0	0.1	0.0	0.2

Hub : Genes

ZNF608

Models

Trait associations