Hub : Genes

MEOX2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1050	0.0280	5.6e-07	0.078	0.066	0.060	0.073	0.081	1.0e-09	1.7e-08	8.0e-08	3.5e-09	4.4e-10
2	GTEx	Artery Aorta	0.1280	0.0520	5.1e-03	0.012	NA	0.038	NA	0.011	7.0e-02	NA	3.4e-03	NA	7.9e-02
3	GTEx	Artery Tibial	0.1132	0.0422	9.2e-04	0.003	NA	0.031	NA	0.005	1.9e-01	NA	1.6e-03	NA	1.3e-01
4	GTEx	Brain Putamen basal ganglia	0.2670	0.1140	9.1e-03	-0.009	NA	-0.012	NA	-0.011	6.1e-01	NA	7.8e-01	NA	7.1e-01
5	ROSMAP	Brain Pre-frontal Cortex	0.0915	0.0283	1.5e-05	0.008	0.052	0.034	0.049	0.035	2.6e-02	2.7e-07	2.6e-05	5.4e-07	2.1e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.3	0.5	0.7	0.2	0.8	0.8	0.6	0.7
Bipolar Disorder or Schizophrenia	0.1	0.2	0.9	-0.9	0.0	-0.0	-0.3	0.0
Depressed Affect (Nagel 2018)	0.8	1.7	5.9	0.9	-0.0	-0.9	-2.4	1.1
Depression (Nagel 2018)	1.7	2.5	3.4	1.4	-1.1	1.9	-1.8	1.7
Intelligence (Savage-Jansen 2018)	0.4	1.2	2.6	0.6	1.2	1.6	1.2	0.4
Neuroticism (Nagel 2018)	1.2	2.7	5.7	1.8	0.1	0.1	-2.4	2.2
Schizophrenia (2018)	0.4	0.8	2.0	-1.4	-0.6	-0.8	-0.9	-0.6
Schizophrenia vs Biploar Disorder	0.5	0.7	1.7	-0.4	-1.3	-1.1	0.6	0.1
Worry (Nagel 2018)	0.9	1.9	5.2	2.3	0.2	0.9	-0.2	1.8
Alzheimer’s Disease (in mother)	1.1	1.3	2.3	0.7	-1.5	-1.5	1.2	0.3
Alzheimer’s Disease (in father)	0.6	0.6	1.2	-0.9	-0.5	0.9	0.3	-1.1
Alzheimer’s Disease (including proxy)	0.4	0.5	1.6	-0.5	-1.3	-0.4	0.2	-0.8
Crohns Disease (2017)	0.1	0.2	0.4	0.4	0.4	0.3	0.2	-0.7
Irritable Bowel Disease (IBD)	0.1	0.2	0.7	-0.5	-0.2	-0.9	0.1	-0.0
Ulcerative Colitis (UC)	0.3	0.6	1.2	-1.1	-0.7	-1.1	-0.1	0.7
Major Depression (MDD)	0.3	0.4	1.3	-0.5	1.1	-0.0	-0.7	0.3
Reaction Time	0.5	1.0	2.4	0.5	-1.2	-0.3	-1.5	0.9
Verbal and Numeric Reasoning (VNR)	0.5	1.2	4.4	0.7	0.9	2.1	0.4	-0.2
Breast Cancer	0.3	0.7	2.3	0.2	0.4	-1.5	-1.1	-0.3
Ovarian Cancer	1.7	2.3	6.2	1.1	-0.4	-0.7	-1.8	2.5
Prostate Cancer	0.4	0.6	1.9	-0.5	-0.9	-0.2	-1.4	-0.0
Age at First Birth	0.3	0.4	1.1	0.4	-0.2	0.2	-0.7	-1.1
Bipolar Disorder (2011)	1.0	0.9	2.8	0.6	-0.4	1.7	1.1	-0.2
Body Mass Index (BMI) (2010)	1.1	1.5	4.5	-0.7	-1.0	-2.1	1.1	0.8
Coronary Artery Disease (CAD)	0.6	0.7	2.0	1.0	-0.4	-0.6	0.1	1.4
Crohns Disease (2012)	0.6	1.0	3.2	0.0	-0.1	-0.1	1.2	-1.8
Mean Putamen Volume	0.2	0.3	0.6	0.7	0.2	0.8	0.2	0.3
Fasting Glucose	0.9	1.1	2.4	-0.6	-1.5	-1.3	0.7	0.8
HbA1C	1.7	1.8	6.1	1.5	0.3	0.6	0.7	2.5
HDL Cholesterol	2.1	3.5	6.7	0.4	2.6	1.0	2.0	-2.4
LDL Cholesterol	0.9	1.5	4.8	2.2	-0.4	1.4	-0.3	0.6
Lupus	0.6	0.9	3.1	0.1	0.6	-0.3	-1.8	0.9
Neuroticism (2016)	0.6	0.9	1.6	0.5	0.4	-1.1	1.1	1.3
Primary Biliary Cirrhosis	0.7	1.0	3.7	-0.6	-0.0	0.5	1.9	0.7
Rheumatoid Arthritis	0.1	0.2	0.4	0.1	-0.4	0.0	-0.4	0.7
Schizophrenia (2014)	0.2	0.4	0.8	-0.6	-0.9	-0.9	-0.4	0.3
Triglycerides	3.2	5.3	12.1	1.5	-3.5	-1.4	-1.8	2.7
Type 2 Diabetes (T2D) (2012)	2.2	2.5	4.5	1.0	-2.0	-1.0	-1.5	2.1
Ulcerative Colitis	0.4	0.6	1.4	-0.6	-0.7	-1.2	0.0	0.6
Blood Eosinophil Count	0.4	2.8	7.3	-1.9	-1.6	-2.7	-0.5	0.6
Blood Platelet Count	0.2	2.2	3.2	-1.8	1.8	-0.9	-1.7	-0.8
Blood Red Count	0.1	1.0	2.2	1.1	-0.9	0.5	-0.6	1.5
Blood White Count	0.0	0.3	0.6	0.4	0.8	-0.3	-0.7	0.5
Heel T-Score	5.7	45.1	100.0	-7.6	-7.0	-10.0	-1.6	-4.1
BMI	0.4	2.5	5.2	-2.1	1.4	0.7	-0.4	-2.3
Height	0.3	6.4	14.1	3.8	1.3	3.6	-1.6	1.0
Waist Hip Ratio (WHR)	0.5	2.4	4.5	1.1	-1.9	1.7	-2.1	-0.2
Systolic Blood Pressure	0.5	2.7	8.8	1.1	1.6	3.0	-0.7	0.7
Smoking Status	0.4	1.0	2.3	-0.8	0.7	1.5	-1.1	-0.7
Allergy or Eczema	1.0	2.7	5.1	-0.8	-2.3	-1.7	1.4	1.7
Cardiovascular Disease	0.9	3.0	8.8	2.4	-0.4	0.6	-0.3	3.0
Hypothyroidism (self reported)	0.4	0.8	3.0	-1.7	0.2	-0.6	-0.4	0.7
Respiratory disease	0.5	1.0	2.1	1.5	0.3	1.2	0.2	1.2
Type 2 Diabetes (T2D) (2018)	2.9	5.5	7.2	1.9	-2.4	-2.0	-2.6	2.7
Lung FEV1/FVC ratio	1.2	6.2	11.8	-3.4	2.3	2.2	-0.8	-2.9
Lung FVC	1.8	9.3	17.6	-4.2	-1.8	-2.6	4.1	-1.2
Neuroticism	0.5	1.3	2.8	1.5	0.6	-0.0	-0.9	1.7
Chronotype (morning person)	0.1	0.1	0.7	0.8	0.0	0.1	0.0	0.2
Hair Pigment	0.0	1.0	1.9	0.5	1.4	0.5	1.0	1.2
Tanning	0.1	1.5	2.4	-1.4	0.7	-1.6	0.7	-1.4
Hand grip strength (left)	3.3	8.6	13.0	3.2	2.8	3.5	-0.2	3.6
Number of treatments/medications taken	0.3	0.5	1.6	0.1	-0.5	0.5	-0.3	1.3
Average weekly spirits intake	0.7	0.9	1.9	-1.3	-0.4	-1.4	-0.2	0.8
Sensitivity / hurt feelings	1.1	1.8	2.9	1.0	1.2	1.6	-1.7	1.1
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.3	1.0	-0.3	1.5	0.3	1.3
Hearing difficulty/problems: Yes	2.1	3.3	7.1	2.0	-1.4	-0.6	-2.7	1.7
Relative age of first facial hair	0.6	1.2	3.1	1.5	0.4	0.3	1.8	0.6
Other serious medical condition/disability diagnosed by doctor	2.2	2.8	6.3	1.3	-2.4	-0.3	0.2	2.5
Ever used hormone-replacement therapy (HRT)	1.1	1.4	4.0	2.0	0.8	0.0	-0.7	1.3
Ever had hysterectomy (womb removed)	0.3	0.3	1.1	-0.1	1.0	-0.1	-0.6	0.4
Systolic blood pressure, automated reading	0.8	2.3	5.0	-0.9	2.2	2.2	-0.4	-0.9
Eye problems/disorders: Diabetes related eye disease	2.6	2.8	8.8	0.8	-1.4	-1.0	-1.3	3.0
Angina	0.7	1.0	3.0	0.5	-1.2	0.3	-0.3	1.7
Medication for hormone replacement therapy	0.6	0.6	1.7	1.3	0.1	0.9	-0.5	0.6
Vitamin and mineral supplements	0.6	0.9	3.8	-0.4	1.9	0.6	-0.2	0.3
Supplements: Zinc	1.8	2.0	4.8	-2.1	0.0	-0.9	0.3	-2.2
Medication: Co-codamol	0.5	0.6	1.9	0.8	1.4	0.3	-0.6	0.3
Medication: Metformin	0.4	0.6	2.0	-0.2	0.2	-0.9	0.1	1.4
Diabetes (father)	1.4	1.7	4.4	1.5	0.4	-1.1	0.6	2.1
Diabetes (mother)	2.1	2.7	6.8	-2.6	-1.1	-2.2	-0.9	0.3
Severe depression (siblings)	1.7	1.9	5.6	0.9	-1.4	-1.2	-0.1	2.4
Pack years adult smoking proportion	0.6	0.9	3.4	-0.3	0.7	1.9	0.1	-0.8
Impedance of leg (right)	1.0	5.1	13.0	3.1	-1.6	0.3	-0.5	3.6
Leg fat-free mass (left)	0.3	1.7	3.4	0.5	1.8	1.5	-1.4	-0.9
Trunk fat percentage	0.1	0.5	1.0	-0.3	1.0	-0.1	-1.0	0.4
Hand grip strength (right)	3.7	10.0	18.7	4.3	2.2	3.2	-0.2	4.1
Townsend deprivation index at recruitment	0.7	1.0	2.9	-0.6	-1.2	0.1	1.7	-0.1
Current tobacco smoking	0.3	0.5	2.1	-1.4	0.1	0.6	-0.2	0.2
Average weekly fortified wine intake	0.5	0.6	1.4	-0.5	-1.2	-0.7	-0.3	1.0
Maternal smoking around birth	0.7	1.0	3.5	-1.9	1.2	-0.6	-0.2	-0.0
Fed-up feelings	0.4	0.6	2.2	-0.4	-0.0	-0.5	-1.5	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.4	1.6	-0.6	0.9	-0.5	0.9
Relative age voice broke	0.3	0.4	1.5	0.5	1.2	-0.3	0.2	0.3
Taking other prescription medications	0.9	1.3	4.2	-0.4	-0.1	1.0	1.1	2.0
Age when periods started (menarche)	0.4	0.9	3.2	-0.2	1.8	0.8	0.3	-0.7
Bilateral oophorectomy (both ovaries removed)	1.9	2.1	6.7	-0.9	1.6	2.6	-0.7	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	5.3	12.1	35.0	-3.5	-3.5	-5.9	0.6	-1.0
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.6	0.5	-0.6	0.6	-1.5	1.6
Qualifications: CSEs or equivalent	0.3	0.4	1.1	-0.7	0.2	-0.4	-0.5	1.0
Serious illness, injury or assault to yourself	0.7	0.8	2.0	1.4	-0.3	1.4	-0.2	-0.1
High blood pressure	0.9	2.4	6.1	2.0	-0.9	1.1	-0.6	2.5
Hayfever, allergic rhinitis or eczema	1.0	2.2	4.9	-2.2	-1.6	-1.8	0.1	0.1
Multivitamins +/- minerals	0.5	0.7	1.9	1.0	-1.4	-0.6	0.3	-0.4
Stomach or abdominal pain in last month	0.5	0.6	0.9	-0.8	-1.0	-0.8	0.7	0.8
Supplements: Glucosamine	0.6	0.8	2.2	0.3	0.7	0.9	-1.5	-0.6
Diverticular disease/diverticulitis (self-reported)	2.2	2.6	6.4	-0.5	-2.5	-2.2	-1.0	0.7
Medication: Atenolol	0.7	0.9	3.8	0.5	-0.5	2.0	0.2	0.0
Medication: Levothyroxine sodium	0.8	1.4	3.1	-0.5	1.4	1.0	0.6	1.8
Sitting height	0.6	4.2	9.2	3.0	0.9	-0.8	-2.5	2.0
Chronic bronchitis/emphysema (father)	1.0	1.2	2.5	1.0	0.9	-0.0	1.2	1.6
High blood pressure (mother)	0.5	0.7	1.1	-1.0	1.0	0.4	0.9	-0.6
Body mass index (BMI)	0.4	1.6	3.5	-1.7	1.9	-0.3	-0.6	-1.0
Impedance of leg (left)	1.0	4.6	11.5	2.7	-2.1	0.1	0.0	3.4
Leg predicted mass (left)	0.3	1.7	3.1	0.6	1.8	1.4	-1.4	-1.0
Trunk fat mass	0.2	0.7	1.8	-0.2	1.4	0.4	-1.3	0.3
Waist circumference	0.1	0.3	1.4	0.0	0.4	0.3	-1.2	0.1
Number of incorrect matches in round	0.2	0.3	0.7	-0.5	0.3	0.8	0.1	-0.8
Past tobacco smoking	0.3	0.5	1.9	-0.3	-0.0	-1.4	0.4	0.7
Alcohol usually taken with meals	0.8	1.2	3.5	-1.9	0.3	-1.0	-0.9	-0.8
Nervous feelings	0.5	1.0	2.1	1.5	0.5	0.9	1.2	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.8	0.8	-0.2	-0.1	0.2	0.9
Hearing difficulty/problems with background noise	0.8	1.3	3.0	0.2	-1.1	-1.7	-1.5	0.4
Hair/balding pattern: Pattern 2	0.5	0.6	1.6	-0.2	-0.2	1.2	0.1	1.3
Had menopause	0.2	0.2	0.5	0.7	0.1	0.1	0.5	0.5
Had other major operations	0.5	0.6	1.8	0.9	0.4	1.3	-0.0	-0.5
Forced vital capacity (FVC)	0.4	1.6	3.6	-0.4	-1.8	-1.0	1.9	0.4
Heel bone mineral density (BMD) T-score, automated (right)	4.7	10.8	26.0	-3.3	-3.9	-5.1	-1.2	-0.9
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.7	0.5	0.7	1.6	-0.6	0.4
Qualifications: None of the above	0.1	0.2	0.6	0.6	-0.8	-0.1	-0.2	0.5
Financial difficulties in last 2 years	1.0	1.4	2.8	-1.6	-0.4	-1.7	1.1	-0.3
Mouth/teeth dental problems	0.9	1.4	3.2	-0.1	0.7	1.4	1.1	-1.8
Heart attack	0.4	0.5	0.9	0.9	-0.9	0.4	-0.7	0.6
Allergy	0.3	0.7	1.0	1.0	0.7	0.9	0.4	-0.9
Pain all over the body in last month	0.6	0.6	2.2	-0.7	-1.5	0.2	0.6	0.4
Diabetes (self-reported)	1.4	2.2	6.2	1.9	-0.7	-0.7	-0.6	2.5
Hayfever/allergic rhinitis (self-reported)	1.8	2.4	4.7	-1.9	1.1	-0.6	1.4	-2.2
Medication: Ramipril	2.8	3.6	9.0	3.0	0.2	1.0	-2.0	2.1
Medication: Simvastatin	1.0	1.4	5.5	0.1	-0.8	-0.7	-0.7	2.3
Fluid intelligence score	0.2	0.3	0.9	0.1	0.8	1.0	-0.1	-0.0
Illnesses of siblings	0.8	1.2	3.1	0.8	-1.0	-1.8	1.0	0.5
Neuroticism score	0.3	0.6	1.2	1.0	0.3	0.8	-0.3	1.1
Weight	0.2	1.2	3.1	0.5	1.8	0.9	-1.3	-0.2
Impedance of arm (right)	0.2	1.1	2.6	1.6	0.2	0.4	1.6	0.2
Arm fat percentage (right)	0.4	1.6	3.5	-1.9	1.8	0.2	-0.1	-1.1
Trunk fat-free mass	0.4	2.1	5.0	0.9	1.6	2.2	-1.4	-0.5
Hip circumference	0.2	1.0	3.0	-0.2	1.7	-0.4	-1.2	0.5
Time employed in main current job	0.2	0.2	0.8	0.3	0.1	-0.4	0.1	-0.9
Alcohol intake versus 10 years previously	1.7	2.6	6.0	0.3	2.5	2.3	0.0	-1.3
Father’s age at death	0.9	1.2	2.7	-1.5	0.5	0.9	-0.3	-1.6
Worrier / anxious feelings	0.4	0.7	2.4	0.1	1.0	1.5	-0.0	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	4.4	2.1	0.4	1.1	-0.0	1.3
Falls in the last year	1.3	1.8	4.5	-0.1	-1.5	-1.5	0.1	2.1
Hair/balding pattern: Pattern 3	0.7	1.1	3.5	-0.6	-1.1	-1.9	-0.2	-0.5
Number of live births	0.3	0.5	0.8	-0.1	0.7	0.9	0.7	0.7
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.3	-1.1	-1.2	-0.4	1.5	-0.1
Pulse rate	0.9	1.6	4.7	1.0	-1.1	-0.9	0.2	2.2
Happiness	0.1	0.2	0.3	-0.6	-0.3	-0.1	-0.5	-0.2
Noisy workplace	0.8	0.9	2.2	-0.5	-1.3	-0.7	-0.3	-1.5
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.5	0.2	-0.5	-0.7	0.1	-0.6
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	2.9	-0.3	-0.0	0.9	1.7	-1.5
Mouth/teeth dental problems: Dentures	0.4	0.7	2.7	0.6	-0.5	0.3	-1.6	0.4
Asthma	0.2	0.4	1.3	0.6	0.4	1.1	0.4	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.1	0.1	-0.8	-0.6	-0.3	-1.1
Medication: Cholesterol lowering	0.2	0.3	1.2	-0.4	0.3	0.2	0.1	1.1
Depression (self-reported)	0.7	0.8	1.4	1.1	-0.1	0.5	-1.0	1.2
Medication: Lansoprazole	1.4	1.6	5.5	0.4	-1.3	-2.4	0.1	0.7
Prospective memory result	0.8	1.0	2.3	-0.6	-1.3	-0.3	1.5	-0.8
Lung cancer (father)	0.2	0.2	0.7	0.1	0.2	0.9	0.2	0.4
Illnesses of mother	1.1	1.3	2.9	1.4	-0.6	1.7	1.1	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	2.2	-0.9	-0.6	-0.3	1.5	-0.1
Pulse wave Arterial Stiffness index	1.9	2.2	5.2	-1.1	-0.4	2.3	1.6	-1.4
Impedance of arm (left)	0.3	1.2	4.2	2.1	-0.6	-0.3	1.0	0.5
Arm fat mass (right)	0.3	1.3	3.3	-1.2	1.8	0.5	-0.9	-0.8
Trunk predicted mass	0.4	2.1	4.9	0.8	1.6	2.2	-1.4	-0.5
Standing height	0.7	6.7	20.3	4.5	0.1	2.8	-1.5	1.8
Length of working week for main job	0.2	0.2	0.6	-0.5	0.3	0.1	0.2	-0.8
Exposure to tobacco smoke at home	1.9	2.1	6.1	2.5	0.7	1.8	0.9	0.0
Breastfed as a baby	0.6	0.7	1.5	-0.5	0.8	-0.9	0.5	-1.2
Tense / ‘highly strung’	1.2	2.0	4.5	1.9	-1.0	0.0	1.0	2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	2.1	3.2	12.6	1.3	-0.9	0.2	-1.0	3.5
Hair/balding pattern: Pattern 4	0.4	1.1	3.6	0.6	0.4	1.1	1.9	0.0
Birth weight of first child	0.1	0.3	1.1	-0.5	-0.1	-1.0	0.1	0.1
Peak expiratory flow (PEF)	0.1	0.2	0.8	-0.0	-0.2	-0.4	0.0	0.9
Pulse wave reflection index	0.9	1.1	2.5	-1.3	-0.8	0.6	-0.1	-1.6
Ever highly irritable/argumentative for 2 days	1.0	1.2	3.3	0.8	-0.1	-1.1	-1.0	1.8
Loud music exposure frequency	2.3	2.5	4.1	1.8	0.3	1.4	-1.9	2.0
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.4	0.1	-0.2	-0.6	-0.7	0.2
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.6	-0.3	0.8	-0.5	-0.0	0.5
Blood clot in the leg (DVT)	0.9	1.2	5.3	0.3	-0.3	-0.4	-0.5	2.3
Medication: Paracetamol	0.5	0.8	2.2	-1.0	-0.8	-1.5	0.3	0.3
Headache pain in last month	0.4	0.7	2.6	-0.3	1.6	0.2	0.0	0.9
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.1	-0.0	-0.2	-0.3	-0.3	-1.1
Glaucoma (self-reported)	1.6	1.8	3.9	-2.0	0.9	0.1	1.1	-1.8
Gout (self-reported)	2.8	3.8	7.0	-0.5	2.6	2.6	0.4	-2.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.5	-0.9	0.3	-0.6	0.7	1.2
Medication: Amlodipine	0.3	0.5	1.6	0.4	-0.7	-0.3	-1.2	-0.0
Medication: Ventolin 100micrograms inhaler	0.6	0.8	3.1	0.3	0.3	-0.1	-1.8	0.8
Birth weight	1.0	2.1	3.2	0.9	1.0	1.7	1.7	-1.8
Chronic bronchitis/emphysema (mother)	2.5	2.9	6.3	2.3	1.3	-0.3	-0.9	2.5
High blood pressure (siblings)	1.7	2.4	7.1	-0.6	1.4	2.7	0.1	-1.6
Forced vital capacity (FVC), Best measure	0.3	1.1	3.9	-0.3	-1.1	-0.5	2.0	0.3
Body fat percentage	0.1	0.5	1.0	-0.7	1.0	-0.3	-0.8	0.5
Leg fat percentage (right)	0.2	0.7	1.7	-0.3	0.8	-0.4	-0.9	1.3
Arm fat-free mass (right)	0.3	1.5	4.6	1.1	0.8	1.0	-2.1	0.5
Exposure to tobacco smoke outside home	3.3	4.4	14.3	1.6	-2.1	-0.9	0.1	3.8
Comparative body size at age 10	1.3	3.6	5.7	-2.3	-1.3	-2.4	0.5	-2.3
Number of full brothers	1.1	1.4	2.7	1.5	-0.5	1.6	1.0	0.9
Worry too long after embarrassment	1.0	1.7	5.1	1.7	0.7	2.3	0.3	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	1.0	2.2	-0.4	-0.7	0.5	1.3	1.5
Wheeze or whistling in the chest in last year	1.1	2.0	4.2	1.1	-0.3	1.4	-2.0	1.6
Number of children fathered	0.9	1.1	1.8	0.4	1.3	1.2	-0.5	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.0	0.2	0.3	0.6	-1.0	-0.0
Age at first live birth	0.8	1.4	3.7	1.2	-0.7	-1.9	-0.6	-0.9
Pulse wave peak to peak time	2.2	2.6	4.8	1.6	0.2	-2.2	-1.6	1.7
Health satisfaction	0.8	1.0	2.8	-1.0	0.7	0.7	0.4	-1.7
Shortness of breath walking on level ground	0.8	1.0	2.5	0.4	-1.6	-1.1	-0.9	-0.2
Qualifications: College or University degree	0.5	1.5	3.6	-0.8	0.7	-1.5	0.9	-1.9
Eye problems/disorders: None of the above	1.0	1.1	3.0	-1.3	-0.2	-0.8	1.7	0.2
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.4	1.3	-1.5	-0.9	0.7	1.3
Emphysema/chronic bronchitis	1.2	1.4	3.1	1.7	-0.7	-1.8	0.5	0.1
Medication for pain relief, constipation, heartburn	0.8	1.4	2.5	-0.4	1.6	1.5	0.8	-1.2
Neck or shoulder pain in last month	1.0	1.5	2.8	0.8	1.2	1.7	-1.1	1.1
Medication: Blood pressure	0.2	0.3	0.8	0.6	-0.4	0.3	-0.2	0.9
Angina (self-reported)	0.9	1.2	3.3	0.8	-1.2	0.7	-0.2	1.8
Migraine (self-reported)	0.5	0.7	1.0	-1.0	1.0	-0.7	0.7	-0.6
Medication: Ibuprofen	0.5	0.6	1.6	-0.2	-0.5	-0.5	-1.0	-1.3
Medication: Allopurinol	2.8	3.8	7.6	-0.6	2.3	2.8	0.1	-2.3
Medication: Omeprazole	0.6	0.7	1.8	-0.4	-0.4	-1.1	-0.6	1.3
Medication: Seretide 50 evohaler	0.7	0.8	2.1	-0.3	1.1	1.4	-0.7	-0.2
Mean time to correctly identify matches	0.9	1.6	3.7	-1.3	-1.9	-0.8	-1.3	0.6
Heart disease (mother)	0.7	0.8	2.2	0.5	-0.1	-0.2	-1.2	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.0	2.7	1.6	0.5	1.6	-1.4	1.5
Whole body fat mass	0.2	0.7	1.7	-0.5	1.3	0.1	-1.3	0.2
Leg fat mass (right)	0.2	0.8	2.2	-0.4	1.0	0.1	-1.5	0.8
Arm predicted mass (right)	0.3	1.4	4.5	1.0	0.7	1.1	-2.1	0.2
Pulse rate, automated reading	0.7	2.2	3.8	1.9	-1.0	-0.5	-1.5	2.0
Alcohol intake frequency.	0.8	1.8	4.6	-0.1	-2.0	-0.6	-0.5	2.1
Comparative height size at age 10	0.8	4.4	10.2	3.2	-1.9	0.7	-1.7	2.2
Number of full sisters	0.8	1.0	1.3	0.9	-1.2	1.1	0.5	1.0
Suffer from ‘nerves’	0.4	0.6	2.5	0.1	0.5	0.5	1.6	0.1
Overall health rating	1.3	2.9	6.3	1.5	0.6	2.5	-0.7	2.3
Chest pain or discomfort	1.6	2.3	9.5	0.7	-0.9	-0.4	-0.8	3.1
Had major operations	0.1	0.1	0.4	0.1	0.5	-0.0	-0.0	0.6
Age at last live birth	1.3	1.8	8.6	0.7	-0.3	-0.2	-2.9	-0.0
Family relationship satisfaction	1.1	1.3	2.8	0.7	-1.2	-0.3	-1.7	1.3
Leg pain on walking	1.7	2.2	5.3	-0.3	2.2	2.3	0.2	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.9	-0.0	1.7	-0.6	-1.4	0.5
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.8	0.0	1.3	0.0	-1.1	0.8
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.0	0.9	-0.1	-0.0	0.0	1.0
Medication: Aspirin	0.8	1.1	2.2	1.5	0.3	-0.9	-1.1	1.0
Supplements: Vitamin C	0.9	1.1	3.4	-1.1	-0.5	-1.8	-0.8	-0.2
Knee pain experienced in last month	0.5	0.8	1.5	1.2	0.8	0.8	-1.0	0.6
Hypertension (Self-reported)	0.9	2.4	5.6	2.0	-0.7	1.4	-0.6	2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	4.9	-0.2	0.1	-0.9	-0.5	2.2
Illnesses of father: Heart disease	0.6	0.9	2.3	-1.5	-0.0	1.3	-0.6	-0.2
Illnesses of siblings: Diabetes	0.6	0.7	2.5	-0.9	0.1	-0.3	-1.6	0.5
Smoking status: Previous	0.5	0.8	1.8	0.9	0.8	0.8	0.3	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	2.0	4.1	9.2	3.0	0.4	2.6	-0.7	2.0
Whole body fat-free mass	0.3	1.8	3.4	0.7	1.5	1.9	-1.5	-0.7
Leg fat-free mass (right)	0.3	1.4	2.7	0.4	1.6	1.2	-1.1	-1.3
Arm fat percentage (left)	0.3	1.3	3.1	-1.4	1.8	-0.2	-0.3	-1.1
Average weekly red wine intake	0.9	1.3	3.3	-1.8	-0.6	-1.5	-0.3	-0.9
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.1	-1.0	-0.6	-0.1	-0.4	-1.4
Mood swings	0.6	1.2	2.7	-1.0	-1.7	-1.4	-0.3	0.2
Loneliness, isolation	0.9	1.3	2.8	1.7	-0.6	-0.8	-0.2	1.6
Long-standing illness, disability or infirmity	1.1	1.7	3.5	1.0	-1.7	0.5	0.7	1.9
Ever had bowel cancer screening	0.6	0.7	1.5	-1.0	-0.9	-1.2	-0.2	0.2
Diabetes diagnosed by doctor	2.5	4.1	10.7	2.4	-1.2	-1.0	-1.3	3.3
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.2	-0.8	1.1	0.5	0.5	-1.1
Friendships satisfaction	0.8	1.0	2.8	1.7	0.8	0.8	0.2	0.9
Qualifications: nursing, teaching	0.1	0.2	0.8	-0.1	-0.4	0.2	0.9	-0.4
Commuting to job workplace: Walk	0.9	0.9	2.8	0.8	1.1	1.7	0.2	-0.1
Eye problems/disorders: Cataract	0.8	0.9	2.3	1.5	-0.1	-0.3	-1.4	-0.3
Mouth/teeth dental problems: Mouth ulcers	1.4	2.3	4.6	1.4	-1.1	-2.2	0.7	1.8
Medication for cholesterol	3.0	4.5	11.6	-2.5	0.8	-1.6	1.2	-3.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.8	-0.5	-1.1	-1.4	0.0	-0.7
Back pain experienced in last month	2.0	2.9	8.5	1.3	-1.4	-0.0	-1.6	2.9
Mineral and other dietary supplements	0.5	0.7	1.5	0.8	-0.3	0.5	0.9	1.2
Breast cancer (self-reported)	0.7	0.8	1.4	-1.2	-1.2	-0.0	-0.5	1.0
Asthma (self-reported)	0.2	0.5	1.5	0.6	0.6	1.2	0.3	0.2
Osteoporosis (self-reported)	1.7	2.1	7.4	0.3	-1.6	-0.8	0.2	2.7
Osteoarthritis (self-reported)	1.3	1.7	3.3	-1.0	0.0	1.7	1.0	-1.8
Medication: Aspirin	1.0	1.2	2.4	1.5	-0.0	-1.0	-1.3	1.1
Medication: Gliclazide	0.7	0.7	2.9	0.5	0.1	-0.4	-0.6	1.7
Illnesses of father: None of the above (group 1)	1.2	1.4	4.5	0.4	0.1	-2.1	1.2	-1.1
Smoking status: Current	0.3	0.5	1.6	-1.3	-0.1	0.6	-0.7	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	6.2	-2.5	0.4	-0.5	1.8	-1.9
Whole body water mass	0.3	1.8	3.4	0.6	1.5	1.9	-1.5	-0.8
Leg predicted mass (right)	0.3	1.4	2.5	0.4	1.6	1.2	-1.1	-1.3
Arm fat mass (left)	0.3	1.1	3.7	-0.9	1.9	0.3	-0.7	-0.7
Number of self-reported non-cancer illnesses	0.6	1.0	3.6	0.7	-0.8	0.5	0.3	1.9
Average weekly champagne plus white wine intake	1.3	1.8	4.4	-1.7	-0.0	-2.1	-0.6	-1.2
Miserableness	0.5	0.9	1.6	-0.7	1.3	-0.3	-1.2	-1.1
Guilty feelings	2.7	4.1	14.1	1.2	-1.5	-1.3	-0.9	3.8
Wears glasses or contact lenses	0.4	0.4	0.9	0.0	0.9	-0.7	0.5	0.8
Ever taken oral contraceptive pill	0.7	0.8	2.6	-0.4	-0.5	-1.6	1.0	0.1
Hearing aid user	3.2	3.7	9.9	3.1	-0.8	0.2	-1.6	2.2
Mother’s age at death	1.2	1.5	3.9	-2.0	0.8	0.7	-0.3	-1.5
Financial situation satisfaction	0.3	0.4	1.3	-0.5	-1.1	-0.5	0.2	0.1
Tinnitus: Yes, now most or all of the time	0.9	1.1	3.6	-0.2	0.5	-1.9	-1.2	0.3
Commuting to job workplace: Public transport	0.8	1.0	2.6	0.2	-1.6	-1.1	-1.0	-0.2
Eye problems/disorders: Glaucoma	1.2	1.5	1.8	-1.3	1.2	1.2	1.0	-1.3
Medication: Blood pressure	1.4	2.6	5.6	2.4	-1.1	1.0	-0.4	2.3
Pain type(s) experienced in last month: Hip pain	1.7	2.2	6.3	1.0	-0.7	0.2	-2.5	1.8
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.2	-0.4	0.9	-0.2	-0.8	-1.1
High cholesterol (Self-reported)	1.5	2.6	11.7	-0.0	-0.1	0.1	-1.1	3.4
Medication: Bendroflumethiazide	1.0	1.5	3.4	1.1	-1.5	-0.4	0.8	1.8
Medication: Paracetamol	0.4	0.7	1.4	-0.6	-1.1	-1.2	-0.3	0.5
Medication: Lisinopril	0.5	0.6	1.5	0.1	-1.0	-0.8	1.2	0.2
Medication: Atorvastatin	1.4	1.7	2.5	1.6	1.3	0.9	1.2	1.5
Illnesses of father: High blood pressure	1.0	1.3	3.0	0.8	0.1	1.3	-1.7	1.0
Alcohol drinker status: Never	1.0	1.2	2.6	-0.3	-0.9	-1.6	-1.1	1.0
Ever smoked	0.6	1.1	4.5	-0.3	-0.6	2.1	-0.7	0.1
Basal metabolic rate	0.3	1.7	2.9	0.8	1.6	1.7	-1.5	-0.6
Leg fat percentage (left)	0.1	0.5	1.2	-0.6	0.8	-0.3	-0.6	1.1
Arm fat-free mass (left)	0.3	1.4	2.8	0.6	1.1	1.7	-1.6	0.0
Number of operations (self-reported)	0.2	0.4	1.2	0.5	0.1	0.1	0.5	1.1
Average weekly beer plus cider intake	1.9	2.7	8.0	1.4	1.9	2.8	0.3	0.3
Irritability	1.1	1.9	2.6	1.3	-1.3	-1.1	-1.5	1.6
Risk taking	0.2	0.4	0.8	-0.6	-0.2	-0.8	0.9	-0.0
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.1	-1.1	-0.4	-0.5	0.5	-0.8
Fractured/broken bones in last 5 years	1.0	1.3	2.0	1.0	-1.2	-1.2	-0.7	1.4
Age started oral contraceptive pill	0.9	1.2	2.7	0.6	-1.6	-0.6	-0.2	1.6
Diastolic blood pressure, automated reading	0.7	2.1	5.0	-0.9	1.1	2.2	-0.7	-1.8
Ever depressed for a whole week	0.4	0.5	1.4	0.5	-0.6	1.2	-0.6	0.5
Unable to work because of sickness or disability	1.1	1.5	2.9	-1.4	-0.5	0.4	1.4	1.7
Commuting to job workplace: Cycle	1.0	1.2	2.7	1.2	-0.8	0.8	-1.7	0.8
Myopia	0.9	1.4	2.9	-1.7	0.7	-1.7	-0.1	0.7
Vascular/heart problems diagnosed by doctor	0.8	2.1	5.4	-1.6	0.4	-1.4	0.3	-2.3
Cholesterol lowering medication	2.7	3.9	12.7	1.2	-1.5	-0.4	-1.7	3.6
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.8	-0.4	-0.9	-1.1	0.3	1.4
Pain experienced in last month	1.0	1.7	5.6	-0.9	-0.1	-1.1	0.9	-2.4
Supplements: Calcium	1.4	1.6	3.5	-0.3	-1.7	0.4	1.0	1.9
Basal cell carcinoma (self-reported)	0.5	0.6	2.4	0.1	-0.6	-0.3	-0.4	1.6
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.8	0.9	-0.7	0.4	-0.8	0.5
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	5.0	0.5	-0.2	-0.5	-0.4	2.2
Heart disease (siblings)	0.6	0.7	2.5	0.0	-0.1	0.2	-1.1	1.6
Alcohol drinker status: Previous	1.6	1.8	5.2	-0.3	-2.3	0.3	0.5	1.8
Pack years of smoking	0.5	0.7	2.7	-0.2	0.5	1.6	0.0	-0.7
Impedance of whole body	0.5	2.6	5.6	2.4	-1.6	-0.1	0.5	2.2
Leg fat mass (left)	0.2	0.6	1.6	-0.5	0.9	0.1	-1.3	0.7
Arm predicted mass (left)	0.3	1.4	3.5	0.5	1.0	1.5	-1.9	-0.1