Hub : Genes

MEOX2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1050 0.0280 5.6e-07 0.078 0.066 0.060 0.073 0.081 1.0e-09 1.7e-08 8.0e-08 3.5e-09 4.4e-10
2 GTEx Artery Aorta 0.1280 0.0520 5.1e-03 0.012 NA 0.038 NA 0.011 7.0e-02 NA 3.4e-03 NA 7.9e-02
3 GTEx Artery Tibial 0.1132 0.0422 9.2e-04 0.003 NA 0.031 NA 0.005 1.9e-01 NA 1.6e-03 NA 1.3e-01
4 GTEx Brain Putamen basal ganglia 0.2670 0.1140 9.1e-03 -0.009 NA -0.012 NA -0.011 6.1e-01 NA 7.8e-01 NA 7.1e-01
5 ROSMAP Brain Pre-frontal Cortex 0.0915 0.0283 1.5e-05 0.008 0.052 0.034 0.049 0.035 2.6e-02 2.7e-07 2.6e-05 5.4e-07 2.1e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.3 0.5 0.7 0.2 0.8 0.8 0.6 0.7
Bipolar Disorder or Schizophrenia 0.1 0.2 0.9 -0.9 0.0 -0.0 -0.3 0.0
Depressed Affect (Nagel 2018) 0.8 1.7 5.9 0.9 -0.0 -0.9 -2.4 1.1
Depression (Nagel 2018) 1.7 2.5 3.4 1.4 -1.1 1.9 -1.8 1.7
Intelligence (Savage-Jansen 2018) 0.4 1.2 2.6 0.6 1.2 1.6 1.2 0.4
Neuroticism (Nagel 2018) 1.2 2.7 5.7 1.8 0.1 0.1 -2.4 2.2
Schizophrenia (2018) 0.4 0.8 2.0 -1.4 -0.6 -0.8 -0.9 -0.6
Schizophrenia vs Biploar Disorder 0.5 0.7 1.7 -0.4 -1.3 -1.1 0.6 0.1
Worry (Nagel 2018) 0.9 1.9 5.2 2.3 0.2 0.9 -0.2 1.8
Alzheimer’s Disease (in mother) 1.1 1.3 2.3 0.7 -1.5 -1.5 1.2 0.3
Alzheimer’s Disease (in father) 0.6 0.6 1.2 -0.9 -0.5 0.9 0.3 -1.1
Alzheimer’s Disease (including proxy) 0.4 0.5 1.6 -0.5 -1.3 -0.4 0.2 -0.8
Crohns Disease (2017) 0.1 0.2 0.4 0.4 0.4 0.3 0.2 -0.7
Irritable Bowel Disease (IBD) 0.1 0.2 0.7 -0.5 -0.2 -0.9 0.1 -0.0
Ulcerative Colitis (UC) 0.3 0.6 1.2 -1.1 -0.7 -1.1 -0.1 0.7
Major Depression (MDD) 0.3 0.4 1.3 -0.5 1.1 -0.0 -0.7 0.3
Reaction Time 0.5 1.0 2.4 0.5 -1.2 -0.3 -1.5 0.9
Verbal and Numeric Reasoning (VNR) 0.5 1.2 4.4 0.7 0.9 2.1 0.4 -0.2
Breast Cancer 0.3 0.7 2.3 0.2 0.4 -1.5 -1.1 -0.3
Ovarian Cancer 1.7 2.3 6.2 1.1 -0.4 -0.7 -1.8 2.5
Prostate Cancer 0.4 0.6 1.9 -0.5 -0.9 -0.2 -1.4 -0.0
Age at First Birth 0.3 0.4 1.1 0.4 -0.2 0.2 -0.7 -1.1
Bipolar Disorder (2011) 1.0 0.9 2.8 0.6 -0.4 1.7 1.1 -0.2
Body Mass Index (BMI) (2010) 1.1 1.5 4.5 -0.7 -1.0 -2.1 1.1 0.8
Coronary Artery Disease (CAD) 0.6 0.7 2.0 1.0 -0.4 -0.6 0.1 1.4
Crohns Disease (2012) 0.6 1.0 3.2 0.0 -0.1 -0.1 1.2 -1.8
Mean Putamen Volume 0.2 0.3 0.6 0.7 0.2 0.8 0.2 0.3
Fasting Glucose 0.9 1.1 2.4 -0.6 -1.5 -1.3 0.7 0.8
HbA1C 1.7 1.8 6.1 1.5 0.3 0.6 0.7 2.5
HDL Cholesterol 2.1 3.5 6.7 0.4 2.6 1.0 2.0 -2.4
LDL Cholesterol 0.9 1.5 4.8 2.2 -0.4 1.4 -0.3 0.6
Lupus 0.6 0.9 3.1 0.1 0.6 -0.3 -1.8 0.9
Neuroticism (2016) 0.6 0.9 1.6 0.5 0.4 -1.1 1.1 1.3
Primary Biliary Cirrhosis 0.7 1.0 3.7 -0.6 -0.0 0.5 1.9 0.7
Rheumatoid Arthritis 0.1 0.2 0.4 0.1 -0.4 0.0 -0.4 0.7
Schizophrenia (2014) 0.2 0.4 0.8 -0.6 -0.9 -0.9 -0.4 0.3
Triglycerides 3.2 5.3 12.1 1.5 -3.5 -1.4 -1.8 2.7
Type 2 Diabetes (T2D) (2012) 2.2 2.5 4.5 1.0 -2.0 -1.0 -1.5 2.1
Ulcerative Colitis 0.4 0.6 1.4 -0.6 -0.7 -1.2 0.0 0.6
Blood Eosinophil Count 0.4 2.8 7.3 -1.9 -1.6 -2.7 -0.5 0.6
Blood Platelet Count 0.2 2.2 3.2 -1.8 1.8 -0.9 -1.7 -0.8
Blood Red Count 0.1 1.0 2.2 1.1 -0.9 0.5 -0.6 1.5
Blood White Count 0.0 0.3 0.6 0.4 0.8 -0.3 -0.7 0.5
Heel T-Score 5.7 45.1 100.0 -7.6 -7.0 -10.0 -1.6 -4.1
BMI 0.4 2.5 5.2 -2.1 1.4 0.7 -0.4 -2.3
Height 0.3 6.4 14.1 3.8 1.3 3.6 -1.6 1.0
Waist Hip Ratio (WHR) 0.5 2.4 4.5 1.1 -1.9 1.7 -2.1 -0.2
Systolic Blood Pressure 0.5 2.7 8.8 1.1 1.6 3.0 -0.7 0.7
Smoking Status 0.4 1.0 2.3 -0.8 0.7 1.5 -1.1 -0.7
Allergy or Eczema 1.0 2.7 5.1 -0.8 -2.3 -1.7 1.4 1.7
Cardiovascular Disease 0.9 3.0 8.8 2.4 -0.4 0.6 -0.3 3.0
Hypothyroidism (self reported) 0.4 0.8 3.0 -1.7 0.2 -0.6 -0.4 0.7
Respiratory disease 0.5 1.0 2.1 1.5 0.3 1.2 0.2 1.2
Type 2 Diabetes (T2D) (2018) 2.9 5.5 7.2 1.9 -2.4 -2.0 -2.6 2.7
Lung FEV1/FVC ratio 1.2 6.2 11.8 -3.4 2.3 2.2 -0.8 -2.9
Lung FVC 1.8 9.3 17.6 -4.2 -1.8 -2.6 4.1 -1.2
Neuroticism 0.5 1.3 2.8 1.5 0.6 -0.0 -0.9 1.7
Chronotype (morning person) 0.1 0.1 0.7 0.8 0.0 0.1 0.0 0.2
Hair Pigment 0.0 1.0 1.9 0.5 1.4 0.5 1.0 1.2
Tanning 0.1 1.5 2.4 -1.4 0.7 -1.6 0.7 -1.4
Hand grip strength (left) 3.3 8.6 13.0 3.2 2.8 3.5 -0.2 3.6
Number of treatments/medications taken 0.3 0.5 1.6 0.1 -0.5 0.5 -0.3 1.3
Average weekly spirits intake 0.7 0.9 1.9 -1.3 -0.4 -1.4 -0.2 0.8
Sensitivity / hurt feelings 1.1 1.8 2.9 1.0 1.2 1.6 -1.7 1.1
Frequency of depressed mood in last 2 weeks 0.7 1.0 2.3 1.0 -0.3 1.5 0.3 1.3
Hearing difficulty/problems: Yes 2.1 3.3 7.1 2.0 -1.4 -0.6 -2.7 1.7
Relative age of first facial hair 0.6 1.2 3.1 1.5 0.4 0.3 1.8 0.6
Other serious medical condition/disability diagnosed by doctor 2.2 2.8 6.3 1.3 -2.4 -0.3 0.2 2.5
Ever used hormone-replacement therapy (HRT) 1.1 1.4 4.0 2.0 0.8 0.0 -0.7 1.3
Ever had hysterectomy (womb removed) 0.3 0.3 1.1 -0.1 1.0 -0.1 -0.6 0.4
Systolic blood pressure, automated reading 0.8 2.3 5.0 -0.9 2.2 2.2 -0.4 -0.9
Eye problems/disorders: Diabetes related eye disease 2.6 2.8 8.8 0.8 -1.4 -1.0 -1.3 3.0
Angina 0.7 1.0 3.0 0.5 -1.2 0.3 -0.3 1.7
Medication for hormone replacement therapy 0.6 0.6 1.7 1.3 0.1 0.9 -0.5 0.6
Vitamin and mineral supplements 0.6 0.9 3.8 -0.4 1.9 0.6 -0.2 0.3
Supplements: Zinc 1.8 2.0 4.8 -2.1 0.0 -0.9 0.3 -2.2
Medication: Co-codamol 0.5 0.6 1.9 0.8 1.4 0.3 -0.6 0.3
Medication: Metformin 0.4 0.6 2.0 -0.2 0.2 -0.9 0.1 1.4
Diabetes (father) 1.4 1.7 4.4 1.5 0.4 -1.1 0.6 2.1
Diabetes (mother) 2.1 2.7 6.8 -2.6 -1.1 -2.2 -0.9 0.3
Severe depression (siblings) 1.7 1.9 5.6 0.9 -1.4 -1.2 -0.1 2.4
Pack years adult smoking proportion 0.6 0.9 3.4 -0.3 0.7 1.9 0.1 -0.8
Impedance of leg (right) 1.0 5.1 13.0 3.1 -1.6 0.3 -0.5 3.6
Leg fat-free mass (left) 0.3 1.7 3.4 0.5 1.8 1.5 -1.4 -0.9
Trunk fat percentage 0.1 0.5 1.0 -0.3 1.0 -0.1 -1.0 0.4
Hand grip strength (right) 3.7 10.0 18.7 4.3 2.2 3.2 -0.2 4.1
Townsend deprivation index at recruitment 0.7 1.0 2.9 -0.6 -1.2 0.1 1.7 -0.1
Current tobacco smoking 0.3 0.5 2.1 -1.4 0.1 0.6 -0.2 0.2
Average weekly fortified wine intake 0.5 0.6 1.4 -0.5 -1.2 -0.7 -0.3 1.0
Maternal smoking around birth 0.7 1.0 3.5 -1.9 1.2 -0.6 -0.2 -0.0
Fed-up feelings 0.4 0.6 2.2 -0.4 -0.0 -0.5 -1.5 0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 2.4 1.6 -0.6 0.9 -0.5 0.9
Relative age voice broke 0.3 0.4 1.5 0.5 1.2 -0.3 0.2 0.3
Taking other prescription medications 0.9 1.3 4.2 -0.4 -0.1 1.0 1.1 2.0
Age when periods started (menarche) 0.4 0.9 3.2 -0.2 1.8 0.8 0.3 -0.7
Bilateral oophorectomy (both ovaries removed) 1.9 2.1 6.7 -0.9 1.6 2.6 -0.7 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 5.3 12.1 35.0 -3.5 -3.5 -5.9 0.6 -1.0
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 2.6 0.5 -0.6 0.6 -1.5 1.6
Qualifications: CSEs or equivalent 0.3 0.4 1.1 -0.7 0.2 -0.4 -0.5 1.0
Serious illness, injury or assault to yourself 0.7 0.8 2.0 1.4 -0.3 1.4 -0.2 -0.1
High blood pressure 0.9 2.4 6.1 2.0 -0.9 1.1 -0.6 2.5
Hayfever, allergic rhinitis or eczema 1.0 2.2 4.9 -2.2 -1.6 -1.8 0.1 0.1
Multivitamins +/- minerals 0.5 0.7 1.9 1.0 -1.4 -0.6 0.3 -0.4
Stomach or abdominal pain in last month 0.5 0.6 0.9 -0.8 -1.0 -0.8 0.7 0.8
Supplements: Glucosamine 0.6 0.8 2.2 0.3 0.7 0.9 -1.5 -0.6
Diverticular disease/diverticulitis (self-reported) 2.2 2.6 6.4 -0.5 -2.5 -2.2 -1.0 0.7
Medication: Atenolol 0.7 0.9 3.8 0.5 -0.5 2.0 0.2 0.0
Medication: Levothyroxine sodium 0.8 1.4 3.1 -0.5 1.4 1.0 0.6 1.8
Sitting height 0.6 4.2 9.2 3.0 0.9 -0.8 -2.5 2.0
Chronic bronchitis/emphysema (father) 1.0 1.2 2.5 1.0 0.9 -0.0 1.2 1.6
High blood pressure (mother) 0.5 0.7 1.1 -1.0 1.0 0.4 0.9 -0.6
Body mass index (BMI) 0.4 1.6 3.5 -1.7 1.9 -0.3 -0.6 -1.0
Impedance of leg (left) 1.0 4.6 11.5 2.7 -2.1 0.1 0.0 3.4
Leg predicted mass (left) 0.3 1.7 3.1 0.6 1.8 1.4 -1.4 -1.0
Trunk fat mass 0.2 0.7 1.8 -0.2 1.4 0.4 -1.3 0.3
Waist circumference 0.1 0.3 1.4 0.0 0.4 0.3 -1.2 0.1
Number of incorrect matches in round 0.2 0.3 0.7 -0.5 0.3 0.8 0.1 -0.8
Past tobacco smoking 0.3 0.5 1.9 -0.3 -0.0 -1.4 0.4 0.7
Alcohol usually taken with meals 0.8 1.2 3.5 -1.9 0.3 -1.0 -0.9 -0.8
Nervous feelings 0.5 1.0 2.1 1.5 0.5 0.9 1.2 0.6
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.8 0.8 -0.2 -0.1 0.2 0.9
Hearing difficulty/problems with background noise 0.8 1.3 3.0 0.2 -1.1 -1.7 -1.5 0.4
Hair/balding pattern: Pattern 2 0.5 0.6 1.6 -0.2 -0.2 1.2 0.1 1.3
Had menopause 0.2 0.2 0.5 0.7 0.1 0.1 0.5 0.5
Had other major operations 0.5 0.6 1.8 0.9 0.4 1.3 -0.0 -0.5
Forced vital capacity (FVC) 0.4 1.6 3.6 -0.4 -1.8 -1.0 1.9 0.4
Heel bone mineral density (BMD) T-score, automated (right) 4.7 10.8 26.0 -3.3 -3.9 -5.1 -1.2 -0.9
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 2.7 0.5 0.7 1.6 -0.6 0.4
Qualifications: None of the above 0.1 0.2 0.6 0.6 -0.8 -0.1 -0.2 0.5
Financial difficulties in last 2 years 1.0 1.4 2.8 -1.6 -0.4 -1.7 1.1 -0.3
Mouth/teeth dental problems 0.9 1.4 3.2 -0.1 0.7 1.4 1.1 -1.8
Heart attack 0.4 0.5 0.9 0.9 -0.9 0.4 -0.7 0.6
Allergy 0.3 0.7 1.0 1.0 0.7 0.9 0.4 -0.9
Pain all over the body in last month 0.6 0.6 2.2 -0.7 -1.5 0.2 0.6 0.4
Diabetes (self-reported) 1.4 2.2 6.2 1.9 -0.7 -0.7 -0.6 2.5
Hayfever/allergic rhinitis (self-reported) 1.8 2.4 4.7 -1.9 1.1 -0.6 1.4 -2.2
Medication: Ramipril 2.8 3.6 9.0 3.0 0.2 1.0 -2.0 2.1
Medication: Simvastatin 1.0 1.4 5.5 0.1 -0.8 -0.7 -0.7 2.3
Fluid intelligence score 0.2 0.3 0.9 0.1 0.8 1.0 -0.1 -0.0
Illnesses of siblings 0.8 1.2 3.1 0.8 -1.0 -1.8 1.0 0.5
Neuroticism score 0.3 0.6 1.2 1.0 0.3 0.8 -0.3 1.1
Weight 0.2 1.2 3.1 0.5 1.8 0.9 -1.3 -0.2
Impedance of arm (right) 0.2 1.1 2.6 1.6 0.2 0.4 1.6 0.2
Arm fat percentage (right) 0.4 1.6 3.5 -1.9 1.8 0.2 -0.1 -1.1
Trunk fat-free mass 0.4 2.1 5.0 0.9 1.6 2.2 -1.4 -0.5
Hip circumference 0.2 1.0 3.0 -0.2 1.7 -0.4 -1.2 0.5
Time employed in main current job 0.2 0.2 0.8 0.3 0.1 -0.4 0.1 -0.9
Alcohol intake versus 10 years previously 1.7 2.6 6.0 0.3 2.5 2.3 0.0 -1.3
Father’s age at death 0.9 1.2 2.7 -1.5 0.5 0.9 -0.3 -1.6
Worrier / anxious feelings 0.4 0.7 2.4 0.1 1.0 1.5 -0.0 0.3
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.5 4.4 2.1 0.4 1.1 -0.0 1.3
Falls in the last year 1.3 1.8 4.5 -0.1 -1.5 -1.5 0.1 2.1
Hair/balding pattern: Pattern 3 0.7 1.1 3.5 -0.6 -1.1 -1.9 -0.2 -0.5
Number of live births 0.3 0.5 0.8 -0.1 0.7 0.9 0.7 0.7
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 2.3 -1.1 -1.2 -0.4 1.5 -0.1
Pulse rate 0.9 1.6 4.7 1.0 -1.1 -0.9 0.2 2.2
Happiness 0.1 0.2 0.3 -0.6 -0.3 -0.1 -0.5 -0.2
Noisy workplace 0.8 0.9 2.2 -0.5 -1.3 -0.7 -0.3 -1.5
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.5 0.2 -0.5 -0.7 0.1 -0.6
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.2 2.9 -0.3 -0.0 0.9 1.7 -1.5
Mouth/teeth dental problems: Dentures 0.4 0.7 2.7 0.6 -0.5 0.3 -1.6 0.4
Asthma 0.2 0.4 1.3 0.6 0.4 1.1 0.4 0.4
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.1 0.1 -0.8 -0.6 -0.3 -1.1
Medication: Cholesterol lowering 0.2 0.3 1.2 -0.4 0.3 0.2 0.1 1.1
Depression (self-reported) 0.7 0.8 1.4 1.1 -0.1 0.5 -1.0 1.2
Medication: Lansoprazole 1.4 1.6 5.5 0.4 -1.3 -2.4 0.1 0.7
Prospective memory result 0.8 1.0 2.3 -0.6 -1.3 -0.3 1.5 -0.8
Lung cancer (father) 0.2 0.2 0.7 0.1 0.2 0.9 0.2 0.4
Illnesses of mother 1.1 1.3 2.9 1.4 -0.6 1.7 1.1 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 2.2 -0.9 -0.6 -0.3 1.5 -0.1
Pulse wave Arterial Stiffness index 1.9 2.2 5.2 -1.1 -0.4 2.3 1.6 -1.4
Impedance of arm (left) 0.3 1.2 4.2 2.1 -0.6 -0.3 1.0 0.5
Arm fat mass (right) 0.3 1.3 3.3 -1.2 1.8 0.5 -0.9 -0.8
Trunk predicted mass 0.4 2.1 4.9 0.8 1.6 2.2 -1.4 -0.5
Standing height 0.7 6.7 20.3 4.5 0.1 2.8 -1.5 1.8
Length of working week for main job 0.2 0.2 0.6 -0.5 0.3 0.1 0.2 -0.8
Exposure to tobacco smoke at home 1.9 2.1 6.1 2.5 0.7 1.8 0.9 0.0
Breastfed as a baby 0.6 0.7 1.5 -0.5 0.8 -0.9 0.5 -1.2
Tense / ‘highly strung’ 1.2 2.0 4.5 1.9 -1.0 0.0 1.0 2.1
Seen doctor (GP) for nerves, anxiety, tension or depression 2.1 3.2 12.6 1.3 -0.9 0.2 -1.0 3.5
Hair/balding pattern: Pattern 4 0.4 1.1 3.6 0.6 0.4 1.1 1.9 0.0
Birth weight of first child 0.1 0.3 1.1 -0.5 -0.1 -1.0 0.1 0.1
Peak expiratory flow (PEF) 0.1 0.2 0.8 -0.0 -0.2 -0.4 0.0 0.9
Pulse wave reflection index 0.9 1.1 2.5 -1.3 -0.8 0.6 -0.1 -1.6
Ever highly irritable/argumentative for 2 days 1.0 1.2 3.3 0.8 -0.1 -1.1 -1.0 1.8
Loud music exposure frequency 2.3 2.5 4.1 1.8 0.3 1.4 -1.9 2.0
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.4 0.1 -0.2 -0.6 -0.7 0.2
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.6 -0.3 0.8 -0.5 -0.0 0.5
Blood clot in the leg (DVT) 0.9 1.2 5.3 0.3 -0.3 -0.4 -0.5 2.3
Medication: Paracetamol 0.5 0.8 2.2 -1.0 -0.8 -1.5 0.3 0.3
Headache pain in last month 0.4 0.7 2.6 -0.3 1.6 0.2 0.0 0.9
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 1.1 -0.0 -0.2 -0.3 -0.3 -1.1
Glaucoma (self-reported) 1.6 1.8 3.9 -2.0 0.9 0.1 1.1 -1.8
Gout (self-reported) 2.8 3.8 7.0 -0.5 2.6 2.6 0.4 -2.2
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.5 -0.9 0.3 -0.6 0.7 1.2
Medication: Amlodipine 0.3 0.5 1.6 0.4 -0.7 -0.3 -1.2 -0.0
Medication: Ventolin 100micrograms inhaler 0.6 0.8 3.1 0.3 0.3 -0.1 -1.8 0.8
Birth weight 1.0 2.1 3.2 0.9 1.0 1.7 1.7 -1.8
Chronic bronchitis/emphysema (mother) 2.5 2.9 6.3 2.3 1.3 -0.3 -0.9 2.5
High blood pressure (siblings) 1.7 2.4 7.1 -0.6 1.4 2.7 0.1 -1.6
Forced vital capacity (FVC), Best measure 0.3 1.1 3.9 -0.3 -1.1 -0.5 2.0 0.3
Body fat percentage 0.1 0.5 1.0 -0.7 1.0 -0.3 -0.8 0.5
Leg fat percentage (right) 0.2 0.7 1.7 -0.3 0.8 -0.4 -0.9 1.3
Arm fat-free mass (right) 0.3 1.5 4.6 1.1 0.8 1.0 -2.1 0.5
Exposure to tobacco smoke outside home 3.3 4.4 14.3 1.6 -2.1 -0.9 0.1 3.8
Comparative body size at age 10 1.3 3.6 5.7 -2.3 -1.3 -2.4 0.5 -2.3
Number of full brothers 1.1 1.4 2.7 1.5 -0.5 1.6 1.0 0.9
Worry too long after embarrassment 1.0 1.7 5.1 1.7 0.7 2.3 0.3 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 1.0 2.2 -0.4 -0.7 0.5 1.3 1.5
Wheeze or whistling in the chest in last year 1.1 2.0 4.2 1.1 -0.3 1.4 -2.0 1.6
Number of children fathered 0.9 1.1 1.8 0.4 1.3 1.2 -0.5 -1.3
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 1.0 0.2 0.3 0.6 -1.0 -0.0
Age at first live birth 0.8 1.4 3.7 1.2 -0.7 -1.9 -0.6 -0.9
Pulse wave peak to peak time 2.2 2.6 4.8 1.6 0.2 -2.2 -1.6 1.7
Health satisfaction 0.8 1.0 2.8 -1.0 0.7 0.7 0.4 -1.7
Shortness of breath walking on level ground 0.8 1.0 2.5 0.4 -1.6 -1.1 -0.9 -0.2
Qualifications: College or University degree 0.5 1.5 3.6 -0.8 0.7 -1.5 0.9 -1.9
Eye problems/disorders: None of the above 1.0 1.1 3.0 -1.3 -0.2 -0.8 1.7 0.2
Mouth/teeth dental problems: Loose teeth 1.2 1.4 2.4 1.3 -1.5 -0.9 0.7 1.3
Emphysema/chronic bronchitis 1.2 1.4 3.1 1.7 -0.7 -1.8 0.5 0.1
Medication for pain relief, constipation, heartburn 0.8 1.4 2.5 -0.4 1.6 1.5 0.8 -1.2
Neck or shoulder pain in last month 1.0 1.5 2.8 0.8 1.2 1.7 -1.1 1.1
Medication: Blood pressure 0.2 0.3 0.8 0.6 -0.4 0.3 -0.2 0.9
Angina (self-reported) 0.9 1.2 3.3 0.8 -1.2 0.7 -0.2 1.8
Migraine (self-reported) 0.5 0.7 1.0 -1.0 1.0 -0.7 0.7 -0.6
Medication: Ibuprofen 0.5 0.6 1.6 -0.2 -0.5 -0.5 -1.0 -1.3
Medication: Allopurinol 2.8 3.8 7.6 -0.6 2.3 2.8 0.1 -2.3
Medication: Omeprazole 0.6 0.7 1.8 -0.4 -0.4 -1.1 -0.6 1.3
Medication: Seretide 50 evohaler 0.7 0.8 2.1 -0.3 1.1 1.4 -0.7 -0.2
Mean time to correctly identify matches 0.9 1.6 3.7 -1.3 -1.9 -0.8 -1.3 0.6
Heart disease (mother) 0.7 0.8 2.2 0.5 -0.1 -0.2 -1.2 1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.7 2.0 2.7 1.6 0.5 1.6 -1.4 1.5
Whole body fat mass 0.2 0.7 1.7 -0.5 1.3 0.1 -1.3 0.2
Leg fat mass (right) 0.2 0.8 2.2 -0.4 1.0 0.1 -1.5 0.8
Arm predicted mass (right) 0.3 1.4 4.5 1.0 0.7 1.1 -2.1 0.2
Pulse rate, automated reading 0.7 2.2 3.8 1.9 -1.0 -0.5 -1.5 2.0
Alcohol intake frequency. 0.8 1.8 4.6 -0.1 -2.0 -0.6 -0.5 2.1
Comparative height size at age 10 0.8 4.4 10.2 3.2 -1.9 0.7 -1.7 2.2
Number of full sisters 0.8 1.0 1.3 0.9 -1.2 1.1 0.5 1.0
Suffer from ‘nerves’ 0.4 0.6 2.5 0.1 0.5 0.5 1.6 0.1
Overall health rating 1.3 2.9 6.3 1.5 0.6 2.5 -0.7 2.3
Chest pain or discomfort 1.6 2.3 9.5 0.7 -0.9 -0.4 -0.8 3.1
Had major operations 0.1 0.1 0.4 0.1 0.5 -0.0 -0.0 0.6
Age at last live birth 1.3 1.8 8.6 0.7 -0.3 -0.2 -2.9 -0.0
Family relationship satisfaction 1.1 1.3 2.8 0.7 -1.2 -0.3 -1.7 1.3
Leg pain on walking 1.7 2.2 5.3 -0.3 2.2 2.3 0.2 -0.8
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 2.9 -0.0 1.7 -0.6 -1.4 0.5
Commuting to job workplace: Car/motor vehicle 0.6 0.7 1.8 0.0 1.3 0.0 -1.1 0.8
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 1.0 0.9 -0.1 -0.0 0.0 1.0
Medication: Aspirin 0.8 1.1 2.2 1.5 0.3 -0.9 -1.1 1.0
Supplements: Vitamin C 0.9 1.1 3.4 -1.1 -0.5 -1.8 -0.8 -0.2
Knee pain experienced in last month 0.5 0.8 1.5 1.2 0.8 0.8 -1.0 0.6
Hypertension (Self-reported) 0.9 2.4 5.6 2.0 -0.7 1.4 -0.6 2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.2 4.9 -0.2 0.1 -0.9 -0.5 2.2
Illnesses of father: Heart disease 0.6 0.9 2.3 -1.5 -0.0 1.3 -0.6 -0.2
Illnesses of siblings: Diabetes 0.6 0.7 2.5 -0.9 0.1 -0.3 -1.6 0.5
Smoking status: Previous 0.5 0.8 1.8 0.9 0.8 0.8 0.3 -1.4
Forced expiratory volume in 1-second (FEV1), predicted 2.0 4.1 9.2 3.0 0.4 2.6 -0.7 2.0
Whole body fat-free mass 0.3 1.8 3.4 0.7 1.5 1.9 -1.5 -0.7
Leg fat-free mass (right) 0.3 1.4 2.7 0.4 1.6 1.2 -1.1 -1.3
Arm fat percentage (left) 0.3 1.3 3.1 -1.4 1.8 -0.2 -0.3 -1.1
Average weekly red wine intake 0.9 1.3 3.3 -1.8 -0.6 -1.5 -0.3 -0.9
Handedness (chirality/laterality): Left-handed 0.6 0.7 2.1 -1.0 -0.6 -0.1 -0.4 -1.4
Mood swings 0.6 1.2 2.7 -1.0 -1.7 -1.4 -0.3 0.2
Loneliness, isolation 0.9 1.3 2.8 1.7 -0.6 -0.8 -0.2 1.6
Long-standing illness, disability or infirmity 1.1 1.7 3.5 1.0 -1.7 0.5 0.7 1.9
Ever had bowel cancer screening 0.6 0.7 1.5 -1.0 -0.9 -1.2 -0.2 0.2
Diabetes diagnosed by doctor 2.5 4.1 10.7 2.4 -1.2 -1.0 -1.3 3.3
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.7 1.2 -0.8 1.1 0.5 0.5 -1.1
Friendships satisfaction 0.8 1.0 2.8 1.7 0.8 0.8 0.2 0.9
Qualifications: nursing, teaching 0.1 0.2 0.8 -0.1 -0.4 0.2 0.9 -0.4
Commuting to job workplace: Walk 0.9 0.9 2.8 0.8 1.1 1.7 0.2 -0.1
Eye problems/disorders: Cataract 0.8 0.9 2.3 1.5 -0.1 -0.3 -1.4 -0.3
Mouth/teeth dental problems: Mouth ulcers 1.4 2.3 4.6 1.4 -1.1 -2.2 0.7 1.8
Medication for cholesterol 3.0 4.5 11.6 -2.5 0.8 -1.6 1.2 -3.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.8 -0.5 -1.1 -1.4 0.0 -0.7
Back pain experienced in last month 2.0 2.9 8.5 1.3 -1.4 -0.0 -1.6 2.9
Mineral and other dietary supplements 0.5 0.7 1.5 0.8 -0.3 0.5 0.9 1.2
Breast cancer (self-reported) 0.7 0.8 1.4 -1.2 -1.2 -0.0 -0.5 1.0
Asthma (self-reported) 0.2 0.5 1.5 0.6 0.6 1.2 0.3 0.2
Osteoporosis (self-reported) 1.7 2.1 7.4 0.3 -1.6 -0.8 0.2 2.7
Osteoarthritis (self-reported) 1.3 1.7 3.3 -1.0 0.0 1.7 1.0 -1.8
Medication: Aspirin 1.0 1.2 2.4 1.5 -0.0 -1.0 -1.3 1.1
Medication: Gliclazide 0.7 0.7 2.9 0.5 0.1 -0.4 -0.6 1.7
Illnesses of father: None of the above (group 1) 1.2 1.4 4.5 0.4 0.1 -2.1 1.2 -1.1
Smoking status: Current 0.3 0.5 1.6 -1.3 -0.1 0.6 -0.7 0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.3 2.7 6.2 -2.5 0.4 -0.5 1.8 -1.9
Whole body water mass 0.3 1.8 3.4 0.6 1.5 1.9 -1.5 -0.8
Leg predicted mass (right) 0.3 1.4 2.5 0.4 1.6 1.2 -1.1 -1.3
Arm fat mass (left) 0.3 1.1 3.7 -0.9 1.9 0.3 -0.7 -0.7
Number of self-reported non-cancer illnesses 0.6 1.0 3.6 0.7 -0.8 0.5 0.3 1.9
Average weekly champagne plus white wine intake 1.3 1.8 4.4 -1.7 -0.0 -2.1 -0.6 -1.2
Miserableness 0.5 0.9 1.6 -0.7 1.3 -0.3 -1.2 -1.1
Guilty feelings 2.7 4.1 14.1 1.2 -1.5 -1.3 -0.9 3.8
Wears glasses or contact lenses 0.4 0.4 0.9 0.0 0.9 -0.7 0.5 0.8
Ever taken oral contraceptive pill 0.7 0.8 2.6 -0.4 -0.5 -1.6 1.0 0.1
Hearing aid user 3.2 3.7 9.9 3.1 -0.8 0.2 -1.6 2.2
Mother’s age at death 1.2 1.5 3.9 -2.0 0.8 0.7 -0.3 -1.5
Financial situation satisfaction 0.3 0.4 1.3 -0.5 -1.1 -0.5 0.2 0.1
Tinnitus: Yes, now most or all of the time 0.9 1.1 3.6 -0.2 0.5 -1.9 -1.2 0.3
Commuting to job workplace: Public transport 0.8 1.0 2.6 0.2 -1.6 -1.1 -1.0 -0.2
Eye problems/disorders: Glaucoma 1.2 1.5 1.8 -1.3 1.2 1.2 1.0 -1.3
Medication: Blood pressure 1.4 2.6 5.6 2.4 -1.1 1.0 -0.4 2.3
Pain type(s) experienced in last month: Hip pain 1.7 2.2 6.3 1.0 -0.7 0.2 -2.5 1.8
Supplements: Fish oil (including cod liver oil) 0.4 0.6 1.2 -0.4 0.9 -0.2 -0.8 -1.1
High cholesterol (Self-reported) 1.5 2.6 11.7 -0.0 -0.1 0.1 -1.1 3.4
Medication: Bendroflumethiazide 1.0 1.5 3.4 1.1 -1.5 -0.4 0.8 1.8
Medication: Paracetamol 0.4 0.7 1.4 -0.6 -1.1 -1.2 -0.3 0.5
Medication: Lisinopril 0.5 0.6 1.5 0.1 -1.0 -0.8 1.2 0.2
Medication: Atorvastatin 1.4 1.7 2.5 1.6 1.3 0.9 1.2 1.5
Illnesses of father: High blood pressure 1.0 1.3 3.0 0.8 0.1 1.3 -1.7 1.0
Alcohol drinker status: Never 1.0 1.2 2.6 -0.3 -0.9 -1.6 -1.1 1.0
Ever smoked 0.6 1.1 4.5 -0.3 -0.6 2.1 -0.7 0.1
Basal metabolic rate 0.3 1.7 2.9 0.8 1.6 1.7 -1.5 -0.6
Leg fat percentage (left) 0.1 0.5 1.2 -0.6 0.8 -0.3 -0.6 1.1
Arm fat-free mass (left) 0.3 1.4 2.8 0.6 1.1 1.7 -1.6 0.0
Number of operations (self-reported) 0.2 0.4 1.2 0.5 0.1 0.1 0.5 1.1
Average weekly beer plus cider intake 1.9 2.7 8.0 1.4 1.9 2.8 0.3 0.3
Irritability 1.1 1.9 2.6 1.3 -1.3 -1.1 -1.5 1.6
Risk taking 0.2 0.4 0.8 -0.6 -0.2 -0.8 0.9 -0.0
Ever had prostate specific antigen (PSA) test 0.4 0.5 1.1 -1.1 -0.4 -0.5 0.5 -0.8
Fractured/broken bones in last 5 years 1.0 1.3 2.0 1.0 -1.2 -1.2 -0.7 1.4
Age started oral contraceptive pill 0.9 1.2 2.7 0.6 -1.6 -0.6 -0.2 1.6
Diastolic blood pressure, automated reading 0.7 2.1 5.0 -0.9 1.1 2.2 -0.7 -1.8
Ever depressed for a whole week 0.4 0.5 1.4 0.5 -0.6 1.2 -0.6 0.5
Unable to work because of sickness or disability 1.1 1.5 2.9 -1.4 -0.5 0.4 1.4 1.7
Commuting to job workplace: Cycle 1.0 1.2 2.7 1.2 -0.8 0.8 -1.7 0.8
Myopia 0.9 1.4 2.9 -1.7 0.7 -1.7 -0.1 0.7
Vascular/heart problems diagnosed by doctor 0.8 2.1 5.4 -1.6 0.4 -1.4 0.3 -2.3
Cholesterol lowering medication 2.7 3.9 12.7 1.2 -1.5 -0.4 -1.7 3.6
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 1.8 -0.4 -0.9 -1.1 0.3 1.4
Pain experienced in last month 1.0 1.7 5.6 -0.9 -0.1 -1.1 0.9 -2.4
Supplements: Calcium 1.4 1.6 3.5 -0.3 -1.7 0.4 1.0 1.9
Basal cell carcinoma (self-reported) 0.5 0.6 2.4 0.1 -0.6 -0.3 -0.4 1.6
Heart attack/myocardial infarction (self-reported) 0.4 0.5 0.8 0.9 -0.7 0.4 -0.8 0.5
Deep venous thrombosis (DVT) (self-reported) 0.9 1.1 5.0 0.5 -0.2 -0.5 -0.4 2.2
Heart disease (siblings) 0.6 0.7 2.5 0.0 -0.1 0.2 -1.1 1.6
Alcohol drinker status: Previous 1.6 1.8 5.2 -0.3 -2.3 0.3 0.5 1.8
Pack years of smoking 0.5 0.7 2.7 -0.2 0.5 1.6 0.0 -0.7
Impedance of whole body 0.5 2.6 5.6 2.4 -1.6 -0.1 0.5 2.2
Leg fat mass (left) 0.2 0.6 1.6 -0.5 0.9 0.1 -1.3 0.7
Arm predicted mass (left) 0.3 1.4 3.5 0.5 1.0 1.5 -1.9 -0.1