TWAS hub - SLC8A1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.2500	0.0650	4.3e-05	0.152	NA	0.114	NA	0.139	1.0e-08	NA	8.2e-07	NA	4.3e-08
2	METSIM	Adipose	0.0761	0.0313	3.8e-03	0.004	0.022	0.013	0.023	0.000	6.9e-02	2.7e-04	3.4e-03	2.1e-04	2.8e-01
3	NTR	Blood	0.0510	0.0143	2.6e-05	0.008	0.022	0.035	0.028	0.033	1.1e-03	1.1e-07	1.9e-11	1.3e-09	6.2e-11
4	TCGA	Glioblastoma Multiforme	0.2270	0.0970	7.9e-03	0.180	0.085	0.059	NA	0.133	3.9e-06	1.5e-03	7.1e-03	NA	7.6e-05
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0831	0.0340	6.5e-03	0.043	-0.002	0.003	NA	0.017	1.1e-05	5.6e-01	1.5e-01	NA	4.3e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Heel bone mineral density (BMD) T-score, automated (left)	4.3	9.7	33.5	5.8	0.5	3.8	-0.3	0.7
Heel bone mineral density (BMD) T-score, automated (right)	4.3	9.9	34.9	5.9	0.8	3.4	0.5	1.6
Heart disease (mother)	4.0	4.9	13.0	2.6	0.3	3.6	-2.2	0.1
Heel T-Score	3.9	30.8	123.2	11.1	-1.3	4.3	3.1	0.6
Number of incorrect matches in round	3.9	6.5	9.2	3.0	3.0	3.0	-1.8	-1.6
Alzheimer’s Disease (in mother)	3.8	4.4	7.6	-2.8	-2.1	-2.3	0.4	-2.1
Medication: Paracetamol	3.5	5.9	13.5	-1.3	-0.7	-3.7	3.7	-0.5
Supplements: Calcium	3.5	3.9	11.5	3.4	1.5	2.1	0.7	0.9
Medication: Paracetamol	3.2	4.9	12.0	-1.0	0.0	-3.4	3.5	-0.5
Cholesterol lowering medication	3.1	4.6	12.2	0.9	0.6	3.5	-2.5	1.8
Average weekly fortified wine intake	2.9	3.4	8.1	-1.2	-0.9	-2.6	2.8	-0.0
Ovarian Cancer	2.8	3.7	9.1	0.8	1.7	2.4	-3.0	-0.6
Hearing aid user	2.8	3.2	6.3	0.4	1.1	-1.5	2.5	2.5
Shortness of breath walking on level ground	2.6	3.0	9.5	-1.5	0.5	-3.1	1.7	0.6
Waist circumference	2.5	9.3	25.0	-1.6	-0.2	-3.9	5.0	1.8
Diverticular disease/diverticulitis (self-reported)	2.4	2.8	7.7	2.8	-0.5	2.5	-0.2	-0.1
Pain all over the body in last month	2.4	2.6	6.2	-0.2	0.4	-2.5	2.4	-0.9
Serious illness, injury or assault of a close relative in last 2 years	2.4	2.7	7.3	0.0	-0.3	1.4	-2.1	-2.7
Irritability	2.3	3.8	7.1	-0.0	-0.2	-2.2	2.7	2.6
Severe depression (siblings)	2.2	2.5	4.2	2.0	-0.1	1.7	-1.4	-1.8
Family relationship satisfaction	2.1	2.6	7.2	2.7	0.7	2.0	-0.8	-0.6
Handedness (chirality/laterality): Left-handed	2.1	2.5	4.6	1.1	1.3	2.1	-1.9	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.2	5.7	-2.4	-0.3	-1.6	-0.9	1.4
Alcohol drinker status: Never	2.1	2.5	5.6	-0.1	-1.0	-2.3	2.4	-0.5
Body mass index (BMI)	2.0	8.6	19.5	-2.3	-1.0	-3.9	4.4	1.1
Alcohol drinker status: Previous	2.0	2.3	3.6	-0.4	-1.1	-1.9	1.8	-1.8
Headache pain in last month	1.9	3.3	6.3	-2.1	-1.4	-2.5	1.5	1.1
Number of full brothers	1.9	2.3	6.7	-1.6	-0.0	-0.8	-1.3	-2.6
Medication: Omeprazole	1.9	2.3	6.6	0.2	-0.7	-1.4	2.6	1.5
Leg fat mass (right)	1.9	7.2	16.9	-1.8	-0.9	-3.2	4.1	2.2
Mouth/teeth dental problems: Mouth ulcers	1.9	3.0	6.3	2.4	2.5	1.5	0.7	0.6
Guilty feelings	1.9	2.8	5.4	0.5	2.3	2.1	-2.0	0.3
Tinnitus: Yes, now most or all of the time	1.9	2.2	5.0	-0.9	-0.4	-2.2	2.1	0.5
Leg fat mass (left)	1.9	7.6	17.9	-1.8	-0.9	-3.3	4.2	2.3
Schizophrenia (2018)	1.8	3.8	11.6	-0.5	2.3	0.7	-1.1	-3.4
Major Depression (MDD)	1.8	2.2	4.3	2.1	2.0	1.7	-0.3	-0.1
Hip circumference	1.8	7.8	17.9	-2.3	-0.6	-3.9	4.2	0.7
Exposure to tobacco smoke outside home	1.8	2.4	7.1	-2.7	-0.0	-1.8	0.0	-1.2
Alcohol intake frequency.	1.8	4.2	7.3	0.6	-2.3	-2.2	2.7	-1.8
Friendships satisfaction	1.8	2.3	6.0	2.4	1.4	1.3	-0.9	-0.9
Leg fat percentage (left)	1.8	6.4	17.0	-1.3	-0.6	-2.9	4.1	2.2
Fractured/broken bones in last 5 years	1.8	2.3	7.5	-2.7	0.6	-0.5	-1.1	-1.5
Triglycerides	1.7	2.7	5.2	-2.0	-0.2	-2.3	2.1	0.4
Medication: Simvastatin	1.7	2.4	5.3	2.1	-0.0	2.3	-0.6	1.5
Arm fat percentage (right)	1.7	6.7	13.5	-2.5	-0.0	-3.3	3.7	1.7
Qualifications: A levels/AS levels or equivalent	1.7	3.7	11.1	-2.0	-0.3	-3.3	1.8	0.5
Leg fat percentage (right)	1.7	6.1	15.6	-1.3	-0.5	-2.9	4.0	2.1
Neck or shoulder pain in last month	1.7	2.5	6.4	2.5	0.8	0.2	2.2	0.8
Whole body fat mass	1.7	7.1	15.4	-2.1	-0.7	-3.2	3.9	2.2
Commuting to job workplace: Public transport	1.7	2.0	4.8	-2.2	0.7	-1.8	-0.5	-1.0
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	6.0	-0.6	2.4	-1.1	1.0	-0.5
Arm fat mass (right)	1.6	6.5	15.5	-2.1	-0.0	-3.3	3.9	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	3.8	-0.4	1.3	-1.6	1.9	-1.1
High cholesterol (Self-reported)	1.6	2.8	6.2	2.3	0.8	2.5	-1.1	0.9
Bipolar Disorder or Schizophrenia	1.5	3.6	9.7	-1.2	3.1	0.1	-1.1	-2.3
LDL Cholesterol	1.5	2.4	8.0	-2.8	0.1	-1.7	-0.0	1.0
Schizophrenia (2014)	1.5	3.3	8.0	-0.3	2.3	0.9	-1.5	-2.8
BMI	1.5	8.6	14.9	-2.8	-2.4	-3.9	3.6	1.2
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	3.4	-1.1	-1.8	-1.5	0.8	-0.8
Supplements: Zinc	1.5	1.6	4.2	2.0	0.9	1.6	-0.5	0.1
Glaucoma (self-reported)	1.5	1.8	4.1	-2.0	0.6	-2.0	0.8	-0.4
Supplements: Vitamin C	1.5	1.8	3.7	0.7	1.8	-0.8	0.8	1.9
Basal cell carcinoma (self-reported)	1.5	1.8	5.1	-0.3	0.7	1.4	-2.2	1.1
Alzheimer’s Disease (including proxy)	1.4	2.0	7.3	-1.2	-2.7	-0.7	-0.7	-0.7
Father’s age at death	1.4	1.9	6.6	-0.5	-2.6	0.6	-1.2	-0.9
Pulse wave reflection index	1.4	1.8	3.5	1.5	1.0	-0.0	1.4	1.9
Body fat percentage	1.4	5.6	11.2	-2.2	-0.3	-2.8	3.4	2.0
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	3.1	-0.1	-0.7	1.5	-1.8	1.5
Arm fat percentage (left)	1.4	5.6	9.8	-2.6	-0.4	-3.0	3.1	1.5
Ever had bowel cancer screening	1.4	1.7	4.2	1.2	-0.4	2.1	-1.5	-0.0
Arm fat mass (left)	1.4	5.6	11.8	-2.3	-0.5	-3.0	3.4	1.3
Ever taken oral contraceptive pill	1.4	1.5	2.1	-0.8	1.4	-1.5	1.4	-1.0
Body Mass Index (BMI) (2010)	1.3	1.8	7.1	-2.7	-0.1	-0.9	-0.6	0.8
Rheumatoid Arthritis	1.3	1.8	3.6	-1.9	-1.2	-1.4	-0.3	-1.4
Type 2 Diabetes (T2D) (2018)	1.3	2.5	5.1	-1.0	0.9	-1.3	2.2	1.9
Chronotype (morning person)	1.3	3.0	6.1	0.0	2.5	1.6	-1.7	-1.9
Trunk fat mass	1.3	5.5	12.1	-2.1	-0.5	-2.7	3.5	1.8
Weight	1.3	6.4	16.9	-1.6	-1.2	-3.0	4.1	1.4
Emphysema/chronic bronchitis	1.3	1.4	4.5	0.7	2.1	0.3	0.0	1.4
Medication for pain relief, constipation, heartburn	1.3	2.3	5.3	0.1	1.7	1.6	-2.3	0.7
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	4.2	1.0	1.4	0.4	0.8	2.1
Eye problems/disorders: Glaucoma	1.3	1.6	3.7	-1.1	-0.6	-1.9	1.6	0.2
Risk taking	1.3	1.9	4.8	-0.2	0.9	2.0	-2.2	-0.1
Schizophrenia vs Biploar Disorder	1.2	1.5	3.5	1.1	1.2	1.1	-0.6	-1.9
Trunk fat percentage	1.2	4.8	8.6	-2.3	-0.2	-2.5	2.9	1.9
Hearing difficulty/problems with background noise	1.2	1.9	4.4	0.7	1.9	1.0	0.4	2.1
Length of working week for main job	1.2	1.3	2.3	-1.3	1.5	0.3	-1.0	1.3
Number of full sisters	1.2	1.4	2.5	-1.3	0.1	-1.6	0.7	-1.5
Long-standing illness, disability or infirmity	1.2	1.8	5.6	0.0	-0.4	-1.8	2.4	0.2
Medication for cholesterol	1.2	1.8	5.1	-1.4	-1.0	-2.3	1.0	-0.2
Reaction Time	1.1	2.0	3.4	0.7	1.7	1.8	-1.3	-1.4
Medication: Ramipril	1.1	1.4	2.5	0.7	1.6	1.4	-0.2	1.4
Worrier / anxious feelings	1.1	2.1	5.4	2.3	1.5	1.4	-0.1	0.7
Happiness	1.1	1.4	3.6	1.9	1.6	-0.2	0.0	-0.6
Prospective memory result	1.1	1.3	2.8	1.1	0.4	1.7	-0.6	-1.5
Illnesses of mother	1.1	1.3	3.1	-1.5	-0.1	-1.2	0.2	1.8
Mean time to correctly identify matches	1.1	2.0	3.6	1.0	1.6	1.9	-1.4	-1.1
Had major operations	1.1	1.2	3.3	0.4	0.3	-1.1	1.8	-1.1
Diabetes diagnosed by doctor	1.1	1.8	3.6	-0.7	-0.6	-1.0	1.9	1.9
Osteoporosis (self-reported)	1.1	1.3	2.6	1.6	-1.1	1.4	-0.9	-0.3
Average weekly beer plus cider intake	1.1	1.6	3.8	-1.0	1.9	-1.4	1.0	0.7
Breast Cancer	1.0	2.3	4.3	-1.6	-2.1	-0.8	0.2	-2.0
Ever used hormone-replacement therapy (HRT)	1.0	1.2	3.2	0.8	0.4	-0.7	1.8	1.3
Medication: Metformin	1.0	1.4	3.3	-0.7	-0.0	-0.8	1.8	1.6
Diabetes (self-reported)	1.0	1.5	3.7	-0.5	-1.1	-1.1	1.9	0.9
Noisy workplace	1.0	1.2	3.3	1.8	1.1	1.1	0.2	0.6
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	4.1	1.8	2.0	0.6	0.5	-1.3
Wheeze or whistling in the chest in last year	1.0	1.7	4.3	0.1	-0.2	-1.6	1.3	-2.1
Asthma (self-reported)	1.0	2.1	4.8	2.2	1.8	1.3	0.4	-0.3
Miserableness	1.0	1.8	5.8	1.0	-2.4	-0.9	0.9	-0.7
Number of operations (self-reported)	1.0	1.5	3.7	1.9	0.6	-0.4	1.7	-0.7
HbA1C	0.9	1.0	2.3	0.7	0.6	1.5	-1.0	0.9
Average weekly spirits intake	0.9	1.1	3.5	-0.7	-1.0	-0.7	-0.1	1.9
Hearing difficulty/problems: Yes	0.9	1.4	3.9	1.6	0.3	-0.2	2.0	0.7
Leg fat-free mass (left)	0.9	4.9	11.2	-1.8	-1.4	-2.8	3.3	0.4
Leg predicted mass (left)	0.9	5.0	11.2	-1.8	-1.4	-2.9	3.3	0.4
Heart attack	0.9	1.2	3.5	0.5	-1.0	1.9	-0.9	0.5
Hair/balding pattern: Pattern 3	0.9	1.4	4.2	1.4	2.0	0.5	0.5	-0.4
Asthma	0.9	1.8	4.1	2.0	1.8	1.3	0.3	-0.0
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	2.4	1.4	-0.0	-0.3	1.6	1.2
Impedance of arm (left)	0.9	4.2	13.3	-0.2	1.5	2.4	-3.6	0.3
Pulse rate, automated reading	0.9	2.9	9.0	-3.0	-0.6	-1.7	0.2	-1.6
Qualifications: nursing, teaching	0.9	1.4	3.4	-0.3	-1.9	-1.2	1.3	-0.7
Bipolar Disorder (2018)	0.8	1.3	3.7	-1.3	1.9	-0.7	-0.4	0.6
Alzheimer’s Disease (in father)	0.8	0.9	2.9	0.5	-1.1	0.1	-0.0	1.7
Hypothyroidism (self reported)	0.8	1.9	4.3	1.8	2.1	1.3	0.2	-0.4
Hand grip strength (left)	0.8	2.2	5.8	0.8	-2.4	0.3	0.9	-1.9
Angina	0.8	1.0	2.3	-0.9	0.8	1.2	-1.5	0.1
Hand grip strength (right)	0.8	2.1	8.6	0.4	-2.9	-0.1	0.7	-1.1
Serious illness, injury or assault to yourself	0.8	1.0	3.4	0.4	-1.8	-0.5	1.0	-0.3
Fluid intelligence score	0.8	1.7	5.5	-0.5	0.3	-2.3	1.4	0.8
Falls in the last year	0.8	1.1	2.0	-1.4	0.8	-1.3	0.5	1.0
High blood pressure (siblings)	0.8	1.1	3.7	-1.2	-1.9	-0.6	-0.4	0.2
Migraine (self-reported)	0.8	1.0	3.0	-1.7	-0.4	-1.3	0.4	-0.1
Arm predicted mass (right)	0.8	4.0	13.2	-0.3	-1.3	-2.3	3.6	0.1
Commuting to job workplace: Car/motor vehicle	0.8	0.9	3.1	0.9	0.7	1.8	-0.4	0.5
Illnesses of father: Heart disease	0.8	1.1	3.0	1.1	-0.6	1.7	-0.8	-0.4
Leg fat-free mass (right)	0.8	4.5	10.4	-1.8	-1.3	-2.7	3.2	0.3
Back pain experienced in last month	0.8	1.2	3.2	-0.4	0.7	-1.8	0.9	1.1
Leg predicted mass (right)	0.8	4.4	10.2	-1.8	-1.2	-2.7	3.2	0.2
Supplements: Fish oil (including cod liver oil)	0.8	1.1	2.2	1.5	-0.2	1.2	-1.3	-0.2
Basal metabolic rate	0.8	4.2	13.2	-0.8	-1.1	-2.4	3.6	0.5
Age started oral contraceptive pill	0.8	1.1	2.7	1.6	0.8	1.2	0.2	0.8
Arm predicted mass (left)	0.8	4.1	14.7	-0.2	-1.1	-2.1	3.8	0.3
Fasting Glucose	0.7	0.9	2.3	-0.9	-1.0	-0.3	0.2	1.5
Lupus	0.7	1.1	4.0	2.0	-0.3	0.4	0.6	-0.9
Vitamin and mineral supplements	0.7	0.9	2.0	-1.4	-1.1	-0.6	-0.0	1.0
Impedance of leg (right)	0.7	3.6	5.9	2.0	1.9	2.4	-2.1	0.6
Fed-up feelings	0.7	1.3	3.7	0.7	0.2	-1.3	1.9	0.6
Multivitamins +/- minerals	0.7	0.8	2.0	1.4	-0.2	0.6	0.7	-1.1
Medication: Levothyroxine sodium	0.7	1.1	3.9	0.3	2.0	-0.7	0.8	-0.8
Impedance of leg (left)	0.7	3.6	6.0	2.0	2.1	2.4	-1.8	0.8
Had other major operations	0.7	0.9	2.7	0.5	0.6	-0.5	1.0	-1.6
Financial difficulties in last 2 years	0.7	0.9	2.3	-1.5	0.7	-1.2	0.3	0.5
Pulse rate	0.7	1.2	4.9	-2.2	-0.5	-1.0	0.2	-0.3
Lung cancer (father)	0.7	0.8	1.7	-0.8	1.3	0.9	-0.8	-0.4
Blood clot in the leg (DVT)	0.7	0.9	1.6	1.3	-1.1	0.6	-0.1	1.1
Gout (self-reported)	0.7	0.9	1.2	-1.0	1.1	-1.0	-0.7	-1.0
Comparative body size at age 10	0.7	1.8	5.3	1.7	-0.5	2.3	-0.7	0.0
Medication: Allopurinol	0.7	1.0	2.1	-1.4	0.4	-1.4	0.2	-0.8
Medication: Seretide 50 evohaler	0.7	0.8	2.2	0.6	0.2	1.1	-1.5	-0.4
Average weekly red wine intake	0.7	1.1	3.0	1.1	-1.7	1.0	-0.3	0.2
Medication: Lisinopril	0.7	0.9	2.5	0.2	-0.6	-0.6	1.0	1.6
Arm fat-free mass (left)	0.7	3.6	13.0	-0.2	-1.0	-1.9	3.6	0.4
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.2	0.2	-1.2	1.5	-0.7	0.3
Crohns Disease (2017)	0.6	1.4	2.9	0.9	-1.5	1.1	-0.0	1.7
Blood White Count	0.6	4.1	15.7	-4.0	-0.9	-1.8	-0.2	0.7
Allergy or Eczema	0.6	1.5	2.9	-0.6	0.1	-1.6	1.3	1.7
Number of treatments/medications taken	0.6	1.1	3.0	1.1	-0.8	-0.4	1.7	-0.7
Diabetes (father)	0.6	0.7	2.3	-0.2	-0.5	-0.8	1.5	0.6
Supplements: Glucosamine	0.6	0.8	1.7	0.3	0.5	-1.3	1.3	-0.3
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.3	-0.4	0.4	-1.2	0.3	-1.5
Time employed in main current job	0.6	0.7	1.1	-0.7	0.2	-1.0	0.8	1.1
Medication: Lansoprazole	0.6	0.7	0.8	0.9	-0.9	0.8	0.6	0.8
Tense / ‘highly strung’	0.6	0.9	1.4	-1.0	0.8	-1.2	1.0	0.8
Arm fat-free mass (right)	0.6	3.2	11.1	0.0	-1.2	-1.8	3.3	0.4
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.6	-0.9	1.1	-0.0	-0.5	1.3
Angina (self-reported)	0.6	0.8	1.7	-0.9	0.7	0.9	-1.3	0.4
Medication: Ibuprofen	0.6	0.7	2.1	0.7	-0.4	-0.4	1.5	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	2.3	1.5	0.2	1.1	-0.5	-0.3
Comparative height size at age 10	0.6	3.2	9.2	2.3	0.5	3.0	-1.2	0.2
Suffer from ‘nerves’	0.6	1.0	2.3	-0.6	1.5	0.8	-1.2	-0.6
Medication: Aspirin	0.6	0.8	1.4	1.1	-1.2	1.0	-0.1	-0.7
Illnesses of siblings: Diabetes	0.6	0.7	1.5	1.2	-0.3	0.9	0.8	0.7
Whole body fat-free mass	0.6	3.3	11.1	-0.5	-1.1	-2.0	3.3	0.0
Commuting to job workplace: Walk	0.6	0.6	2.3	-0.2	-0.3	-0.7	-0.1	-1.5
Osteoarthritis (self-reported)	0.6	0.7	1.9	-0.0	1.4	-0.4	0.5	-1.1
Whole body water mass	0.6	3.3	10.8	-0.5	-1.1	-2.0	3.3	0.1
Average weekly champagne plus white wine intake	0.6	0.8	2.0	-1.4	-0.6	-0.8	-1.0	-0.4
Wears glasses or contact lenses	0.6	0.7	2.2	1.5	0.3	1.0	-0.2	0.6
Diastolic blood pressure, automated reading	0.6	1.7	3.7	-1.9	-0.0	-1.8	0.4	-1.2
Commuting to job workplace: Cycle	0.6	0.7	1.8	-0.3	-1.1	-0.5	-0.5	-1.4
Vascular/heart problems diagnosed by doctor	0.6	1.7	3.6	-0.5	-1.3	-1.9	1.6	-0.6
Impedance of whole body	0.6	3.3	8.1	0.5	1.7	2.2	-2.9	0.4
Depressed Affect (Nagel 2018)	0.5	1.1	1.6	1.1	-1.3	-1.1	1.2	0.1
Irritable Bowel Disease (IBD)	0.5	1.1	3.5	0.1	-1.9	0.7	-0.1	1.3
Primary Biliary Cirrhosis	0.5	0.7	1.9	-1.2	1.4	-0.5	-0.2	-0.3
Lung FVC	0.5	2.3	5.0	-0.7	-2.2	0.3	-1.3	2.1
Sensitivity / hurt feelings	0.5	0.8	2.3	1.5	0.8	0.9	0.1	-0.5
Medication for hormone replacement therapy	0.5	0.5	1.3	1.1	-0.5	0.8	0.1	-0.7
Taking other prescription medications	0.5	0.8	1.4	1.1	1.2	0.3	0.6	-1.0
Medication: Atenolol	0.5	0.7	1.2	0.5	1.1	0.9	-0.5	0.8
Illnesses of siblings	0.5	0.8	1.5	-0.7	1.2	-1.1	0.7	0.4
Impedance of arm (right)	0.5	2.3	6.6	-0.2	1.2	1.6	-2.6	0.6
Alcohol intake versus 10 years previously	0.5	0.8	2.7	-0.8	-1.6	-0.0	-0.0	-0.8
Number of live births	0.5	0.7	1.5	1.2	0.9	0.8	-0.1	0.7
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	4.5	-1.8	-2.1	-1.2	-0.0	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	5.2	-1.4	-2.3	-1.1	0.0	-0.2
Pulse wave Arterial Stiffness index	0.5	0.6	1.9	0.0	0.7	0.6	0.6	1.4
Birth weight of first child	0.5	1.0	3.0	1.7	0.4	0.9	0.3	0.8
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.2	-0.5	-0.2	-1.1	0.9	0.7
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	1.9	-1.2	0.0	-1.4	0.0	0.5
Birth weight	0.5	1.1	2.9	-1.7	-0.4	-0.5	-0.5	1.3
Number of children fathered	0.5	0.5	1.6	-1.3	-0.7	0.5	-0.5	0.2
Eye problems/disorders: None of the above	0.5	0.5	1.3	0.1	0.5	1.1	-0.9	0.5
Knee pain experienced in last month	0.5	0.7	1.1	1.0	-1.1	0.7	-0.5	-0.9
Smoking status: Previous	0.5	0.7	1.7	1.3	0.5	0.8	0.9	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.6	-0.1	1.6	-1.0	1.0	-0.9
Medication: Aspirin	0.5	0.7	1.6	1.0	-0.7	1.3	-0.3	-0.6
Medication: Gliclazide	0.5	0.6	2.4	-0.3	-0.2	-0.5	1.6	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	4.8	-0.4	-2.2	-0.1	0.3	-0.3
Number of self-reported non-cancer illnesses	0.5	0.8	2.3	1.5	0.4	0.0	1.3	0.2
Financial situation satisfaction	0.5	0.7	2.0	0.9	0.5	-0.3	0.4	-1.4
Myopia	0.5	0.7	1.8	-0.5	0.9	0.8	-1.3	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	1.7	0.4	-0.2	-0.3	1.3	1.2
Pack years of smoking	0.5	0.7	1.5	-1.1	-0.2	-1.2	0.9	0.1
Depression (Nagel 2018)	0.4	0.6	1.4	0.9	0.1	-0.7	1.2	0.5
Verbal and Numeric Reasoning (VNR)	0.4	0.9	3.6	-0.4	-0.3	-1.9	0.6	0.1
Crohns Disease (2012)	0.4	0.7	1.3	-0.0	-0.9	1.1	-0.9	0.8
Blood Eosinophil Count	0.4	2.8	7.7	-2.8	-0.3	-2.2	1.2	0.1
Waist Hip Ratio (WHR)	0.4	2.0	4.5	1.1	1.8	-0.6	2.1	0.9
Respiratory disease	0.4	0.8	2.3	1.0	1.5	0.1	0.9	-0.2
Neuroticism	0.4	1.0	2.0	1.4	0.4	-0.4	1.0	1.3
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.0	0.5	-0.0	-0.9	1.0	-0.7
Pack years adult smoking proportion	0.4	0.7	1.3	-1.1	-0.2	-1.1	0.8	-0.4
Townsend deprivation index at recruitment	0.4	0.6	2.3	-0.0	-1.5	-0.2	-0.2	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.4	-0.1	0.1	-0.7	0.9	1.2
Age when periods started (menarche)	0.4	0.8	1.6	-0.1	1.3	0.0	-1.2	-1.0
High blood pressure (mother)	0.4	0.5	1.6	0.5	0.6	0.2	0.5	-1.3
Alcohol usually taken with meals	0.4	0.7	2.3	0.8	-1.5	0.5	-0.2	0.4
Qualifications: None of the above	0.4	0.8	3.0	0.4	0.3	-0.1	1.0	1.7
Trunk fat-free mass	0.4	2.3	8.9	0.4	-0.8	-1.3	3.0	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	2.0	0.3	0.4	-1.1	1.4	0.4
Medication: Cholesterol lowering	0.4	0.6	1.5	0.8	-0.7	-0.6	1.2	0.2
Trunk predicted mass	0.4	2.3	8.8	0.3	-0.8	-1.3	3.0	0.1
Peak expiratory flow (PEF)	0.4	1.0	2.8	-1.3	-1.7	-0.7	0.2	-0.3
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.9	-1.4	-0.3	-0.3	0.0	-0.7
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.1	-1.1	0.2	0.2	-1.5	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.7	0.1	-0.6	-1.3	0.7	-0.3
Age at first live birth	0.4	0.7	1.5	-1.0	-1.2	-0.5	0.0	0.7
Pulse wave peak to peak time	0.4	0.4	1.5	0.1	-0.5	-0.4	-0.5	-1.2
Leg pain on walking	0.4	0.5	1.2	0.2	1.1	-0.5	0.6	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.9	-1.0	0.7	0.1	-0.8	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.2	-0.4	0.8	0.4	-0.6	1.1
Loneliness, isolation	0.4	0.6	1.4	-0.8	0.4	-1.2	0.5	0.6
Mineral and other dietary supplements	0.4	0.6	1.9	-1.4	0.2	-0.6	0.4	0.6
Medication: Blood pressure	0.4	0.7	2.3	0.6	1.5	0.8	0.2	0.3
Medication: Atorvastatin	0.4	0.5	1.5	-1.2	-0.6	-0.4	-0.8	0.1
Heart disease (siblings)	0.4	0.5	1.3	0.2	-0.6	0.6	-0.5	-1.2
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.2	0.3	0.0	-1.5	0.9	1.2
Worry (Nagel 2018)	0.3	0.7	1.1	0.9	1.1	0.9	-0.6	0.7
Ulcerative Colitis (UC)	0.3	0.5	2.1	-0.4	-1.4	0.3	-0.3	-0.2
Age at First Birth	0.3	0.5	0.8	-0.6	0.3	0.7	-0.9	0.8
Bipolar Disorder (2011)	0.3	0.3	0.9	-0.2	0.5	0.2	-0.4	-0.9
Mean Putamen Volume	0.3	0.4	1.3	-1.2	0.3	-0.2	-0.5	0.3
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.8	-0.2	-0.1	0.9	-0.8	0.5
Height	0.3	5.9	17.6	4.2	0.5	1.9	1.9	2.1
Cardiovascular Disease	0.3	1.1	2.2	0.4	0.7	1.5	-1.5	-0.5
Ever had hysterectomy (womb removed)	0.3	0.4	0.6	0.3	-0.8	0.0	0.7	0.8
Medication: Co-codamol	0.3	0.3	1.0	1.0	0.6	0.2	0.3	0.1
Diabetes (mother)	0.3	0.4	0.8	-0.1	-0.8	0.4	0.5	0.9
Current tobacco smoking	0.3	0.4	0.9	-0.9	-0.2	-0.5	-0.3	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	2.0	-0.3	1.4	-0.3	0.0	-0.4
Forced vital capacity (FVC)	0.3	1.3	3.3	-1.7	-1.8	-0.8	-0.1	-0.1
Allergy	0.3	0.8	1.3	-0.9	-1.1	-0.0	-0.8	-1.0
Mouth/teeth dental problems: Dentures	0.3	0.5	1.1	-0.2	1.1	-0.9	0.8	0.1
Exposure to tobacco smoke at home	0.3	0.3	1.0	0.2	0.3	-0.4	0.6	-1.0
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.1	-0.2	0.3	-0.8	1.1	-0.4
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.9	-0.6	-0.1	0.1	-0.9	-0.7
Forced vital capacity (FVC), Best measure	0.3	1.2	3.7	-1.3	-1.9	-0.7	-0.2	-0.2
Qualifications: College or University degree	0.3	0.8	2.2	-0.4	-1.0	-1.0	0.2	-1.5
Chest pain or discomfort	0.3	0.4	1.6	0.3	0.4	-0.2	0.1	-1.3
Mood swings	0.3	0.5	1.5	-0.1	-1.2	-0.6	-0.5	-0.5
Eye problems/disorders: Cataract	0.3	0.3	1.0	0.0	-0.2	0.7	-1.0	-0.4
Breast cancer (self-reported)	0.3	0.3	1.1	-0.4	0.4	-0.4	0.1	-1.1
Smoking status: Current	0.3	0.4	0.9	-0.9	-0.4	-0.5	-0.5	0.8
Mother’s age at death	0.3	0.4	1.4	0.0	-1.2	0.2	0.2	-0.8
Medication: Bendroflumethiazide	0.3	0.5	1.3	0.3	-0.1	-0.3	1.0	-1.2
Illnesses of father: High blood pressure	0.3	0.3	0.9	-0.9	0.6	-0.1	-0.5	-0.4
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.2	1.1	0.8	0.3	-0.0	0.2
Pain experienced in last month	0.3	0.5	1.8	-1.3	0.4	-0.4	-0.5	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.8	0.8	-0.9	-0.0	0.4	0.6
Neuroticism (Nagel 2018)	0.2	0.4	1.8	1.3	-0.2	-0.0	0.2	0.5
Coronary Artery Disease (CAD)	0.2	0.2	0.6	0.8	0.3	0.2	0.2	0.6
Neuroticism (2016)	0.2	0.3	0.7	0.4	0.1	-0.5	0.8	0.4
Ulcerative Colitis	0.2	0.3	0.7	-0.8	-0.8	-0.4	0.1	-0.5
Blood Platelet Count	0.2	2.5	7.8	-2.8	-0.7	-1.6	-0.5	-1.1
Blood Red Count	0.2	2.2	7.4	-0.6	-1.3	-0.6	1.1	2.7
Systolic Blood Pressure	0.2	1.0	1.8	-0.4	1.3	-0.7	-1.4	-0.7
Lung FEV1/FVC ratio	0.2	0.9	1.7	-1.0	-1.3	-1.1	0.7	0.3
Systolic blood pressure, automated reading	0.2	0.5	1.4	-0.7	-0.1	-0.4	-0.7	1.2
Maternal smoking around birth	0.2	0.3	0.8	-0.6	-0.3	-0.1	-0.9	0.4
Relative age voice broke	0.2	0.3	1.0	0.0	0.2	-0.7	1.0	-0.4
Qualifications: CSEs or equivalent	0.2	0.2	1.0	-0.1	0.0	-0.3	-0.3	-1.0
High blood pressure	0.2	0.6	1.0	0.1	0.9	1.0	-0.9	0.4
Hayfever, allergic rhinitis or eczema	0.2	0.3	0.8	-0.1	-0.2	-0.9	0.7	0.6
Stomach or abdominal pain in last month	0.2	0.3	0.9	-0.5	0.3	-0.4	0.4	1.0
Sitting height	0.2	1.1	2.6	-1.6	-1.4	-0.9	0.4	-0.1
Nervous feelings	0.2	0.3	0.9	0.2	1.0	0.1	-0.4	0.5
Hair/balding pattern: Pattern 2	0.2	0.2	0.8	-0.1	-0.9	0.3	-0.4	0.2
Had menopause	0.2	0.2	0.6	0.3	-0.7	0.1	0.5	0.3
Mouth/teeth dental problems	0.2	0.4	1.4	0.5	-1.2	0.2	-0.3	-0.0
Neuroticism score	0.2	0.5	0.9	0.8	1.0	-0.1	0.3	0.9
Depression (self-reported)	0.2	0.2	0.4	0.4	-0.0	-0.6	0.6	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	1.3	0.1	1.1	-0.1	-0.4	-0.6
Hair/balding pattern: Pattern 4	0.2	0.6	1.5	-0.3	0.5	-1.0	1.2	-0.1
Loud music exposure frequency	0.2	0.3	0.9	0.5	0.9	-0.2	0.2	-0.4
Medication: Amlodipine	0.2	0.3	0.8	-0.9	-0.4	-0.4	-0.4	-0.2
Worry too long after embarrassment	0.2	0.3	0.7	0.2	0.8	0.2	-0.6	-0.6
Health satisfaction	0.2	0.3	0.8	-0.1	-0.2	-0.7	0.1	-0.9
Medication: Blood pressure	0.2	0.4	1.2	1.1	0.0	0.8	0.3	-0.1
Overall health rating	0.2	0.5	0.7	-0.9	0.5	-0.7	0.6	-0.7
Hypertension (Self-reported)	0.2	0.6	1.2	0.3	0.7	1.1	-0.9	0.5
Illnesses of father: None of the above (group 1)	0.2	0.2	0.9	0.2	0.4	0.2	-0.3	-0.9
Ever smoked	0.2	0.3	0.7	0.9	0.1	0.7	-0.3	-0.1
Ever depressed for a whole week	0.2	0.3	1.2	-0.0	-0.3	-0.1	0.0	-1.1
Unable to work because of sickness or disability	0.2	0.3	1.4	1.2	0.3	0.1	-0.1	-0.3
Prostate Cancer	0.1	0.2	0.5	-0.1	0.3	-0.3	0.7	-0.5
HDL Cholesterol	0.1	0.1	0.2	0.2	0.4	-0.5	0.3	-0.3
Smoking Status	0.1	0.3	0.5	0.0	0.7	0.5	-0.3	0.7
Tanning	0.1	0.7	1.0	0.7	1.0	1.0	-0.7	0.7
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.5	0.3	0.7	-0.3	0.4	-0.2
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	-0.2	0.5	0.1	0.2	-0.0
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.4	0.1	-0.0	-0.3	-0.4
Past tobacco smoking	0.1	0.2	0.4	-0.6	-0.1	-0.3	-0.5	0.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	-0.1	0.1	-0.2	-0.3	-0.6
Standing height	0.1	0.8	2.2	1.1	-0.0	1.5	-0.3	0.8
Breastfed as a baby	0.1	0.1	0.3	0.1	0.3	0.1	-0.3	-0.5
Age at last live birth	0.1	0.2	0.6	-0.4	0.8	-0.4	0.2	-0.1
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	-0.3	-0.1	-0.4	0.2	-0.3
Hair Pigment	0.0	0.5	1.8	0.6	-1.4	0.3	-0.5	0.3
Relative age of first facial hair	0.0	0.1	0.1	-0.4	-0.4	-0.1	-0.2	-0.3

Hub : Genes

SLC8A1

Models

Trait associations