TWAS hub - ZNF827

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.130	0.0480	5.4e-03	0.139	NA	0.095	NA	0.014	4.4e-08	NA	6.5e-06	NA	0.0510
2	GTEx	Artery Tibial	0.163	0.0454	2.3e-05	0.082	NA	0.048	NA	0.023	5.7e-07	NA	1.2e-04	NA	0.0057
3	YFS	Blood	0.023	0.0105	1.1e-02	0.004	0.004	0.008	0.006	0.004	2.0e-02	0.0098	1.1e-03	0.0033	0.0110

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Heel bone mineral density (BMD) T-score, automated (left)	10.0	22.8	26.4	-5.1	-4.5	-4.7
Heel bone mineral density (BMD) T-score, automated (right)	9.4	21.6	23.1	-4.8	-4.4	-4.7
Systolic Blood Pressure	8.5	42.6	64.8	-7.7	-8.1	-1.9
Heel T-Score	7.9	62.5	85.9	-9.3	-7.9	-6.3
Angina	7.8	10.2	14.7	-3.8	-3.0	-2.6
Cholesterol lowering medication	6.8	10.1	12.1	-2.8	-3.5	-3.2
Systolic blood pressure, automated reading	6.4	18.7	28.7	-5.2	-5.4	-0.3
Angina (self-reported)	6.2	8.2	12.0	-3.5	-2.8	-2.1
Coronary Artery Disease (CAD)	6.0	7.1	8.7	-2.9	-2.8	-2.2
Medication: Ibuprofen (e.g. Nurofen)	5.9	7.5	10.2	3.2	3.2	1.5
Asthma	5.0	9.9	17.2	2.2	2.8	4.1
Asthma (self-reported)	4.8	9.6	16.3	2.2	2.8	4.0
Medication: Ibuprofen	4.7	5.6	7.5	2.7	2.7	1.5
Loud music exposure frequency	4.3	4.7	6.4	-1.7	-2.2	-2.5
Health satisfaction	4.2	5.4	5.9	2.4	2.1	2.4
Birth weight of first child	4.1	7.5	12.0	2.2	2.4	3.5
Medication for cholesterol	4.0	6.1	9.2	2.1	3.0	2.2
Reason for reducing amount of alcohol drunk: Health precaution	3.9	4.5	7.0	-2.0	-2.7	-1.6
Medication: Allopurinol	3.7	5.0	11.2	1.6	3.4	-1.0
Medication: Atorvastatin	3.7	4.6	7.0	-2.2	-1.4	-2.6
Unable to work because of sickness or disability	3.7	4.8	5.6	-1.9	-2.3	-2.4
Heart disease (mother)	3.6	4.3	8.1	-2.8	-2.2	-0.3
Basal cell carcinoma (self-reported)	3.4	4.0	5.3	2.3	1.9	1.8
Supplements: Glucosamine	3.3	4.3	6.7	2.4	2.6	0.7
Gout (self-reported)	3.1	4.3	8.5	1.5	2.9	-1.4
Loneliness, isolation	3.0	4.1	7.5	2.7	2.1	0.7
Ever had bowel cancer screening	3.0	3.5	5.3	-1.7	-2.3	-1.5
Medication: Ventolin 100micrograms inhaler	2.8	3.6	5.7	0.9	2.1	2.4
Whole body fat-free mass	2.7	15.6	21.5	4.6	4.1	3.0
Whole body water mass	2.7	15.2	21.5	4.6	4.0	2.9
Arm predicted mass (left)	2.7	13.9	19.4	4.4	3.6	3.0
Trunk fat-free mass	2.6	15.2	22.3	4.7	3.8	3.0
Trunk predicted mass	2.6	15.1	22.2	4.7	3.8	2.9
Age at First Birth	2.5	3.6	5.7	1.2	1.9	2.4
Basal metabolic rate	2.5	14.0	18.9	4.3	3.9	2.9
Reaction Time	2.4	4.6	6.8	1.8	1.9	2.6
Financial difficulties in last 2 years	2.4	3.2	4.5	-1.5	-1.7	-2.1
Pulse wave peak to peak time	2.4	2.9	5.6	1.2	1.3	2.4
Leg predicted mass (right)	2.4	12.8	16.2	4.0	3.9	2.6
Lung FVC	2.3	11.7	18.6	4.3	2.9	2.9
Exposure to tobacco smoke outside home	2.3	3.0	6.0	-1.7	-2.5	0.2
Illnesses of father: Heart disease	2.3	3.1	4.6	-2.1	-2.2	-0.6
Leg fat-free mass (right)	2.3	12.3	15.7	4.0	3.8	2.5
Medication: Gliclazide	2.3	2.6	3.2	-1.8	-1.3	-1.7
Arm fat-free mass (left)	2.3	11.8	16.2	4.0	3.4	2.8
Leg fat-free mass (left)	2.2	11.8	15.6	4.0	3.6	2.6
Leg predicted mass (left)	2.2	11.6	15.5	3.9	3.6	2.5
Serious illness, injury or assault of a close relative in last 2 years	2.1	2.4	3.3	-1.8	-1.2	-1.6
Arm fat-free mass (right)	2.1	10.8	13.9	3.7	3.5	2.5
Migraine (self-reported)	2.1	2.6	7.5	0.5	0.4	2.7
Arm predicted mass (right)	2.1	10.9	14.4	3.8	3.4	2.7
Eye problems/disorders: Glaucoma	2.1	2.5	7.2	0.5	-0.1	2.7
Ever smoked	2.1	3.7	5.5	-1.6	-2.3	-1.8
High blood pressure (siblings)	2.0	2.8	4.4	-2.1	-2.0	-0.4
Mouth/teeth dental problems: Mouth ulcers	2.0	3.1	5.3	-1.5	-2.3	-1.3
Neuroticism	1.9	4.6	6.5	-1.4	-2.6	-2.3
Forced vital capacity (FVC)	1.9	7.3	13.0	3.6	1.9	2.4
Hip circumference	1.9	8.4	11.3	3.4	3.2	1.9
Forced expiratory volume in 1-second (FEV1)	1.9	6.5	11.7	3.4	1.7	2.2
Pulse wave Arterial Stiffness index	1.9	2.3	5.2	-0.7	-1.0	-2.3
Worry (Nagel 2018)	1.8	3.8	6.2	-1.5	-2.5	-1.7
Illnesses of siblings	1.8	2.5	4.1	2.0	1.7	0.7
Weight	1.8	9.0	11.2	3.4	3.1	2.5
Glaucoma (self-reported)	1.8	2.1	5.7	-0.2	-0.7	2.4
Medication: Seretide 50 evohaler	1.8	2.1	4.3	1.0	2.1	1.0
Mean time to correctly identify matches	1.8	3.4	7.0	1.0	1.5	2.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.2	4.7	-2.2	-1.3	-0.5
Height	1.7	32.6	54.9	7.4	5.8	3.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.4	8.6	2.9	1.7	2.1
Ever highly irritable/argumentative for 2 days	1.7	2.0	2.2	1.4	1.5	1.3
Headache pain in last month	1.7	2.9	3.9	1.9	2.0	1.1
High cholesterol (Self-reported)	1.7	2.9	5.2	-1.3	-2.3	-1.4
Falls in the last year	1.6	2.1	3.3	1.8	1.6	-0.7
Current tobacco smoking	1.5	2.4	5.5	-0.9	-1.1	-2.3
Past tobacco smoking	1.5	2.8	4.2	1.5	2.0	1.4
Medication: Simvastatin	1.5	2.2	5.4	-1.1	-2.3	-0.5
Forced vital capacity (FVC), Best measure	1.5	5.6	10.2	3.2	1.8	1.8
Eye problems/disorders: None of the above	1.5	1.8	3.2	-1.8	-0.3	-1.4
Smoking status: Current	1.5	2.4	5.0	-1.0	-1.1	-2.2
Ever had prostate specific antigen (PSA) test	1.5	1.7	2.2	-1.5	-1.1	-1.3
Trunk fat mass	1.4	5.9	7.4	2.4	2.7	2.1
Arm fat mass (right)	1.4	5.6	6.5	2.3	2.6	2.3
Qualifications: nursing, teaching	1.4	2.2	4.0	2.0	1.6	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	2.6	-1.6	-1.5	-0.2
Arm fat mass (left)	1.4	5.6	7.3	2.2	2.7	2.1
Major Depression (MDD)	1.3	1.6	3.1	-1.3	-1.8	-0.3
Taking other prescription medications	1.3	2.0	3.1	1.8	1.6	0.7
Heart attack	1.3	1.7	3.3	-1.8	-1.0	-0.8
Allergy	1.3	2.9	5.2	-0.8	-1.7	-2.3
Depression (self-reported)	1.3	1.5	2.4	-0.8	-1.2	-1.5
Standing height	1.3	13.1	25.4	5.0	3.1	2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	3.6	-1.2	-1.9	-0.6
Leg fat mass (right)	1.3	5.2	5.9	2.2	2.4	2.2
Age at last live birth	1.3	1.9	4.7	2.2	1.0	0.3
Heart disease (siblings)	1.3	1.6	1.8	-1.4	-1.3	-1.1
Irritable Bowel Disease (IBD)	1.2	2.9	6.0	-1.1	-1.2	-2.5
Cardiovascular Disease	1.2	4.0	5.7	-2.4	-1.9	-1.6
Whole body fat mass	1.2	4.9	6.3	2.2	2.5	1.9
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	2.2	1.0	1.1	1.5
Knee pain experienced in last month	1.2	1.9	2.7	1.6	0.8	1.6
Illnesses of father: None of the above (group 1)	1.2	1.4	2.9	1.7	1.0	-0.7
Leg fat mass (left)	1.2	4.6	5.7	2.1	2.4	1.9
Primary Biliary Cirrhosis	1.1	1.5	2.6	1.4	1.6	-0.3
Smoking Status	1.1	2.5	4.7	-1.2	-1.2	-2.2
Severe depression (siblings)	1.1	1.2	1.3	-1.0	-1.2	-1.1
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	2.8	-1.0	-1.7	0.2
Sitting height	1.1	7.5	13.8	3.7	2.2	2.0
Qualifications: None of the above	1.1	2.3	3.8	-2.0	-1.7	-0.4
Happiness	1.1	1.3	1.6	1.0	1.3	1.1
Medication: Cholesterol lowering	1.1	1.7	2.5	-1.3	-1.6	-0.9
Tense / ‘highly strung’	1.1	1.9	3.2	-0.6	-1.8	-1.4
Pulse wave reflection index	1.1	1.3	3.5	-0.7	-0.1	-1.9
Medication: Aspirin	1.1	1.4	2.1	-1.4	-1.5	-0.1
Fractured/broken bones in last 5 years	1.1	1.4	3.1	1.8	0.9	0.5
Prostate Cancer	1.0	1.4	2.0	-1.4	-1.3	-0.7
Mean Putamen Volume	1.0	1.1	1.4	-1.2	-1.1	-0.9
LDL Cholesterol	1.0	1.5	1.6	-1.2	-1.2	-1.3
Ever used hormone-replacement therapy (HRT)	1.0	1.2	3.5	0.4	-0.1	1.9
Diabetes (father)	1.0	1.3	2.8	-1.7	-0.9	0.3
Serious illness, injury or assault to yourself	1.0	1.2	1.9	-1.1	-1.4	-0.7
Arm fat percentage (right)	1.0	3.9	5.0	1.8	2.2	1.9
Breastfed as a baby	1.0	1.2	1.9	0.4	1.2	1.4
Medication for pain relief, constipation, heartburn	1.0	1.6	2.3	-1.5	-1.5	-0.7
Comparative height size at age 10	1.0	5.2	9.9	3.1	2.2	1.1
Risk taking	1.0	1.4	2.0	1.4	1.3	-0.8
Diastolic blood pressure, automated reading	1.0	3.2	6.4	-2.5	-1.7	0.6
Ulcerative Colitis (UC)	0.9	1.7	4.7	-0.4	-0.5	-2.2
Diabetes (self-reported)	0.9	1.3	2.0	-1.4	-0.8	-1.1
Eye problems/disorders: Cataract	0.9	1.0	1.5	1.2	0.2	1.2
Ever taken oral contraceptive pill	0.9	1.0	1.8	1.2	1.3	0.0
Crohns Disease (2017)	0.8	1.6	3.1	-0.8	-1.1	-1.8
Bipolar Disorder (2011)	0.8	0.8	1.5	-1.2	-0.8	-0.6
Ulcerative Colitis	0.8	1.1	1.7	-1.0	-0.8	-1.3
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.3	1.2	0.4	1.0
Family relationship satisfaction	0.8	1.0	1.4	0.8	1.0	1.2
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.3	1.2	1.1	-0.6
Arm fat percentage (left)	0.8	3.0	4.8	1.4	2.2	1.5
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.0	-0.8	-1.4	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.2	1.1	0.9	0.9
Friendships satisfaction	0.8	1.0	2.6	0.3	0.6	1.6
Commuting to job workplace: Walk	0.8	0.8	1.2	-0.8	-0.9	-1.1
Average weekly champagne plus white wine intake	0.8	1.1	2.1	1.1	1.4	0.0
Ever depressed for a whole week	0.8	1.0	2.8	-0.1	-1.7	-0.5
Heart attack/myocardial infarction (self-reported)	0.8	1.1	2.3	-1.5	-0.8	-0.6
Crohns Disease (2012)	0.7	1.1	1.7	-1.3	-1.1	-0.6
Waist Hip Ratio (WHR)	0.7	3.0	4.7	-1.9	-2.2	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.3	1.0	0.6	1.1
Alcohol usually taken with meals	0.7	1.1	1.6	0.8	1.3	-1.0
Hearing difficulty/problems with background noise	0.7	1.1	1.4	-1.2	-1.2	-0.7
Mouth/teeth dental problems	0.7	1.0	2.1	0.8	1.5	0.5
Medication: Lansoprazole	0.7	0.8	1.6	0.5	0.8	-1.2
Exposure to tobacco smoke at home	0.7	0.8	1.1	-1.1	-0.7	0.9
Body fat percentage	0.7	2.7	3.6	1.4	1.9	1.6
Diabetes diagnosed by doctor	0.7	1.1	2.0	-1.4	-1.0	-0.5
Financial situation satisfaction	0.7	0.9	1.4	-0.9	-1.2	0.7
Medication: Blood pressure	0.7	1.2	1.7	-1.3	-1.3	-0.6
Alcohol drinker status: Never	0.7	0.9	1.4	-0.8	-1.2	-0.8
Vascular/heart problems diagnosed by doctor	0.7	2.0	3.2	1.8	1.5	0.8
Body Mass Index (BMI) (2010)	0.6	0.8	1.8	-0.7	0.4	-1.4
Respiratory disease	0.6	1.4	4.1	-0.1	0.4	2.0
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	0.9	0.3	0.9	0.9
Medication: Metformin	0.6	0.8	1.8	-1.4	-0.2	-0.8
Trunk fat percentage	0.6	2.3	3.3	1.3	1.8	1.4
Body mass index (BMI)	0.6	2.6	3.7	1.2	1.9	1.6
Waist circumference	0.6	2.0	2.3	1.5	1.5	1.3
Neuroticism score	0.6	1.3	2.1	-0.3	-1.3	-1.5
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	1.9	-0.8	-0.9	-1.4
Medication: Amlodipine	0.6	0.9	1.6	-1.0	-1.3	-0.2
Worry too long after embarrassment	0.6	1.0	2.5	-0.7	-1.6	-0.3
Medication: Omeprazole	0.6	0.8	1.6	0.5	0.7	1.3
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.6	-0.5	-1.3	0.4
Smoking status: Previous	0.6	0.8	1.4	-0.9	-1.2	-0.5
Guilty feelings	0.6	0.9	1.4	-1.1	-1.2	-0.4
Leg fat percentage (left)	0.6	2.0	2.9	1.1	1.7	1.4
Number of operations (self-reported)	0.6	0.8	2.1	0.3	0.6	1.4
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.2	0.5	0.9	1.1
Pain experienced in last month	0.6	1.0	2.3	-0.8	-0.3	-1.5
Alzheimer’s Disease (in mother)	0.5	0.6	1.1	1.1	0.3	0.7
Blood Eosinophil Count	0.5	4.0	4.7	2.2	2.1	1.6
Blood Platelet Count	0.5	6.1	10.4	-3.2	-2.7	-0.7
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.0	-0.9	-0.2	-1.4
Medication for hormone replacement therapy	0.5	0.5	1.0	-0.7	-1.0	-0.1
Townsend deprivation index at recruitment	0.5	0.7	1.0	-0.5	-1.0	-0.8
Pulse rate	0.5	0.8	0.9	0.8	1.0	0.9
Illnesses of mother	0.5	0.6	1.4	0.2	0.6	-1.2
Leg fat percentage (right)	0.5	1.9	2.3	1.1	1.5	1.5
Qualifications: College or University degree	0.5	1.4	2.2	1.5	1.3	-0.5
Neck or shoulder pain in last month	0.5	0.7	1.5	1.2	0.8	0.2
Medication: Aspirin	0.5	0.7	1.0	-1.0	-1.0	0.2
Commuting to job workplace: Public transport	0.5	0.6	1.2	0.8	1.1	0.1
Commuting to job workplace: Cycle	0.5	0.6	1.1	1.1	0.8	0.4
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.6	-0.5	0.3	-1.3
Impedance of whole body	0.5	2.7	3.9	-1.4	-2.0	-1.4
Bipolar Disorder (2018)	0.4	0.6	0.8	-0.9	-0.6	-0.7
Depression (Nagel 2018)	0.4	0.6	0.9	0.6	0.8	0.9
Lupus	0.4	0.6	1.2	-1.1	-0.8	0.3
Hand grip strength (left)	0.4	1.1	1.6	-0.9	-0.9	-1.2
Number of treatments/medications taken	0.4	0.7	1.8	1.3	0.5	0.1
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.2	1.1	0.5	0.4
Vitamin and mineral supplements	0.4	0.6	1.4	1.2	0.6	0.1
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.4	0.2	1.0	1.2
Number of incorrect matches in round	0.4	0.6	1.5	0.4	0.4	1.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.0	0.6	1.0	0.7
Blood clot in the leg (DVT)	0.4	0.6	1.3	-0.6	0.2	-1.2
Medication: Paracetamol	0.4	0.6	1.1	0.5	0.7	1.0
Emphysema/chronic bronchitis	0.4	0.4	0.5	-0.6	-0.6	-0.7
Medication: Blood pressure	0.4	0.6	1.6	0.4	0.5	1.2
Alcohol intake frequency.	0.4	1.0	1.9	-1.0	-1.4	0.4
Leg pain on walking	0.4	0.5	1.3	0.5	-0.1	1.1
Average weekly red wine intake	0.4	0.6	1.5	-0.2	0.6	-1.2
Back pain experienced in last month	0.4	0.5	0.7	0.6	0.8	0.7
Mineral and other dietary supplements	0.4	0.5	1.2	-1.1	-0.6	-0.0
Pain type(s) experienced in last month: Hip pain	0.4	0.4	1.0	0.3	-0.5	-1.0
Neuroticism (Nagel 2018)	0.3	0.6	1.1	0.0	-0.8	-1.1
Schizophrenia vs Biploar Disorder	0.3	0.4	0.7	0.6	-0.2	0.8
Ovarian Cancer	0.3	0.4	0.8	-0.6	-0.2	-0.9
Rheumatoid Arthritis	0.3	0.4	0.6	0.8	0.6	0.3
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.1	-1.0	-0.0	-0.3
Blood Red Count	0.3	3.1	8.3	-2.9	-1.0	0.2
Blood White Count	0.3	2.2	3.9	-2.0	-0.9	-1.4
Allergy or Eczema	0.3	0.9	2.2	-0.2	0.6	1.5
Hypothyroidism (self reported)	0.3	0.6	1.4	-0.1	-0.7	-1.2
Supplements: Zinc	0.3	0.3	0.5	-0.7	-0.2	-0.6
Impedance of leg (right)	0.3	1.5	3.2	-0.8	-1.8	-0.7
Fed-up feelings	0.3	0.6	1.3	0.5	-0.5	-1.1
High blood pressure	0.3	0.7	1.3	-1.2	-0.9	-0.2
Impedance of leg (left)	0.3	1.4	2.5	-1.0	-1.6	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.9	1.0	0.4	0.7
Had menopause	0.3	0.3	0.4	-0.6	-0.7	0.4
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.8	0.3	-0.9	0.4
Pain all over the body in last month	0.3	0.3	0.8	-0.1	-0.1	0.9
Alcohol intake versus 10 years previously	0.3	0.5	0.8	-0.9	-0.8	0.2
Hair/balding pattern: Pattern 3	0.3	0.4	0.7	-0.7	-0.9	-0.3
Number of live births	0.3	0.4	1.1	1.0	-0.3	0.0
Noisy workplace	0.3	0.3	0.5	-0.0	0.7	0.7
Impedance of arm (left)	0.3	1.3	2.0	-0.9	-1.0	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.4	-0.2	-0.3	1.2
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.6	-0.0	-0.8	0.7
Comparative body size at age 10	0.3	0.7	1.0	0.7	0.9	-1.0
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.4	-0.6	-0.6	-0.5
Pulse rate, automated reading	0.3	0.9	1.1	0.9	1.1	0.9
Number of full sisters	0.3	0.4	0.6	0.7	-0.3	0.6
Suffer from ‘nerves’	0.3	0.5	1.1	-0.0	-1.1	-0.6
Illnesses of siblings: Diabetes	0.3	0.3	0.6	-0.8	-0.6	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.3	1.1	0.2	0.8
Medication: Lisinopril	0.3	0.4	0.7	0.2	-0.7	0.8
Average weekly beer plus cider intake	0.3	0.4	0.5	0.6	0.6	0.7
Supplements: Calcium	0.3	0.3	0.5	0.7	0.7	0.0
Alcohol drinker status: Previous	0.3	0.3	0.8	-0.1	-0.1	0.9
Bipolar Disorder or Schizophrenia	0.2	0.6	1.2	-0.7	-1.1	-0.3
Depressed Affect (Nagel 2018)	0.2	0.4	0.6	0.8	0.6	-0.5
Intelligence (Savage-Jansen 2018)	0.2	0.8	1.3	0.8	1.1	-0.6
Schizophrenia (2018)	0.2	0.3	0.9	-0.2	-1.0	0.3
Alzheimer’s Disease (in father)	0.2	0.2	0.2	-0.5	-0.4	-0.2
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.0	0.1	1.0	-0.8
HbA1C	0.2	0.2	0.6	0.8	-0.1	0.3
Schizophrenia (2014)	0.2	0.4	1.0	-0.1	-1.0	-0.6
BMI	0.2	1.1	1.9	0.3	1.4	1.1
Hair Pigment	0.2	6.9	12.5	2.6	3.5	1.2
Tanning	0.2	2.1	4.7	-0.6	-1.0	-2.2
Hearing difficulty/problems: Yes	0.2	0.4	0.9	-0.5	-0.0	0.9
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.4	-0.6	0.6	-0.2
Medication: Co-codamol	0.2	0.3	0.7	-0.2	0.3	0.8
Average weekly fortified wine intake	0.2	0.3	0.6	-0.8	0.1	0.5
Maternal smoking around birth	0.2	0.3	0.7	-0.2	-0.5	0.8
Age when periods started (menarche)	0.2	0.6	1.2	-0.5	-1.1	0.5
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.4	-0.5	-0.6	0.1
Multivitamins +/- minerals	0.2	0.3	0.4	-0.6	-0.6	0.1
High blood pressure (mother)	0.2	0.2	0.6	-0.2	-0.8	0.3
Nervous feelings	0.2	0.3	0.5	0.7	0.4	-0.6
Medication: Ramipril	0.2	0.2	0.6	-0.7	-0.3	-0.0
Fluid intelligence score	0.2	0.3	0.9	0.2	0.9	-0.2
Time employed in main current job	0.2	0.2	0.6	-0.8	-0.2	0.3
Father’s age at death	0.2	0.3	0.5	0.0	0.5	0.7
Worrier / anxious feelings	0.2	0.4	0.5	-0.7	-0.7	0.3
Lung cancer (father)	0.2	0.2	0.5	0.7	0.4	-0.2
Length of working week for main job	0.2	0.2	0.4	-0.5	0.1	-0.7
Hair/balding pattern: Pattern 4	0.2	0.5	0.8	0.1	-0.8	-0.9
Peak expiratory flow (PEF)	0.2	0.4	0.8	0.9	0.4	-0.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.9	-0.3	0.1	-0.9
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	-0.4	-0.7	0.0
Number of full brothers	0.2	0.3	0.4	0.6	0.3	-0.6
Age at first live birth	0.2	0.3	0.6	0.7	0.5	0.4
Overall health rating	0.2	0.5	0.9	0.8	1.0	-0.3
Had major operations	0.2	0.3	0.6	-0.4	-0.1	0.8
Hypertension (Self-reported)	0.2	0.6	1.3	-1.1	-0.7	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.4	0.7	0.5	0.3
Breast cancer (self-reported)	0.2	0.3	0.5	0.5	0.7	-0.3
Osteoporosis (self-reported)	0.2	0.2	0.6	0.2	0.8	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.8	0.9	0.5	0.1
Wears glasses or contact lenses	0.2	0.2	0.5	0.7	0.3	0.1
Hearing aid user	0.2	0.2	0.5	0.1	-0.2	0.7
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.8	-0.3	-0.9	-0.3
Medication: Bendroflumethiazide	0.2	0.3	0.9	0.1	-1.0	-0.3
Irritability	0.2	0.3	0.4	0.6	-0.6	-0.6
Alzheimer’s Disease (including proxy)	0.1	0.1	0.3	0.5	0.2	0.2
Breast Cancer	0.1	0.4	0.6	0.8	0.4	0.6
Fasting Glucose	0.1	0.1	0.3	0.0	-0.3	-0.6
HDL Cholesterol	0.1	0.2	0.3	-0.4	-0.5	0.5
Neuroticism (2016)	0.1	0.1	0.2	-0.2	-0.5	-0.2
Triglycerides	0.1	0.2	0.2	-0.4	0.4	-0.3
Chronotype (morning person)	0.1	0.3	0.8	-0.1	-0.9	0.3
Average weekly spirits intake	0.1	0.1	0.2	0.2	-0.4	-0.3
Relative age of first facial hair	0.1	0.2	0.3	-0.5	0.4	0.1
Ever had hysterectomy (womb removed)	0.1	0.1	0.1	-0.2	-0.4	0.0
Pack years adult smoking proportion	0.1	0.1	0.3	0.1	-0.6	0.0
Hand grip strength (right)	0.1	0.4	0.7	-0.5	-0.3	-0.8
Relative age voice broke	0.1	0.1	0.2	-0.5	0.1	0.5
Qualifications: CSEs or equivalent	0.1	0.1	0.2	-0.4	-0.2	0.4
Stomach or abdominal pain in last month	0.1	0.1	0.3	0.1	0.2	-0.5
Medication: Atenolol	0.1	0.1	0.2	-0.4	0.3	0.1
Medication: Levothyroxine sodium	0.1	0.1	0.3	-0.0	-0.3	0.5
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.3	0.5	0.2
Hair/balding pattern: Pattern 2	0.1	0.2	0.4	-0.3	0.6	-0.1
Had other major operations	0.1	0.1	0.2	-0.5	-0.2	-0.3
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.3	0.1	0.2	0.6
Impedance of arm (right)	0.1	0.4	1.0	-0.3	-1.0	-0.5
Prospective memory result	0.1	0.1	0.2	0.4	0.4	-0.2
Birth weight	0.1	0.3	0.7	0.2	-0.2	0.8
Wheeze or whistling in the chest in last year	0.1	0.2	0.5	-0.7	0.2	-0.3
Number of children fathered	0.1	0.2	0.2	-0.3	-0.4	-0.5
Shortness of breath walking on level ground	0.1	0.1	0.3	0.4	-0.2	0.5
Chest pain or discomfort	0.1	0.2	0.4	0.3	0.6	0.2
Supplements: Vitamin C	0.1	0.1	0.3	-0.5	-0.2	-0.3
Mood swings	0.1	0.1	0.2	0.5	0.1	-0.4
Long-standing illness, disability or infirmity	0.1	0.1	0.2	-0.5	0.1	-0.4
Osteoarthritis (self-reported)	0.1	0.1	0.3	0.2	-0.1	0.6
Miserableness	0.1	0.2	0.3	0.5	0.3	-0.5
Mother’s age at death	0.1	0.1	0.2	0.4	-0.1	-0.5
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	-0.4	0.2	-0.1
Medication: Paracetamol	0.1	0.2	0.3	0.5	0.1	0.6
Illnesses of father: High blood pressure	0.1	0.1	0.2	0.5	0.2	-0.2
Age started oral contraceptive pill	0.1	0.1	0.2	0.4	0.2	-0.0
Myopia	0.1	0.2	0.3	-0.3	0.6	0.4
Pack years of smoking	0.1	0.1	0.2	0.1	-0.3	0.4
Lung FEV1/FVC ratio	0.0	0.1	0.3	-0.0	0.2	0.6
Sensitivity / hurt feelings	0.0	0.0	0.1	0.2	-0.2	-0.1
Diabetes (mother)	0.0	0.0	0.1	-0.0	0.1	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.0	0.0	-0.1	0.1	-0.2
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.2	0.4	0.1	-0.3
Mouth/teeth dental problems: Dentures	0.0	0.0	0.1	0.0	-0.2	0.3
Number of self-reported non-cancer illnesses	0.0	0.0	0.1	0.1	-0.3	-0.1

Hub : Genes

ZNF827

Models

Trait associations