Hub : Genes

CD109

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0980	0.0290	1.6e-06	0.018	0.065	0.020	0.063	0.014	2.4e-03	2.2e-08	1.6e-03	4.0e-08	7.0e-03
2	GTEx	Artery Aorta	0.3220	0.0640	1.1e-08	0.216	NA	0.231	NA	0.229	4.2e-12	NA	5.9e-13	NA	7.4e-13
3	GTEx	Pancreas	0.1810	0.0660	9.7e-04	0.070	NA	0.057	NA	0.074	6.8e-04	NA	2.0e-03	NA	5.0e-04
4	GTEx	Skin Not Sun Exposed Suprapubic	0.1710	0.0640	6.3e-04	0.022	NA	0.082	NA	0.069	2.1e-02	NA	2.9e-05	NA	1.3e-04
5	GTEx	Spleen	0.2740	0.0900	2.7e-03	0.021	NA	0.013	NA	0.025	9.4e-02	NA	1.4e-01	NA	7.6e-02
6	ROSMAP	Brain Pre-frontal Cortex	0.0407	0.0185	3.2e-03	-0.002	0.008	0.008	0.009	-0.002	6.5e-01	2.8e-02	2.6e-02	2.3e-02	6.6e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.8	1.2	2.3	1.1	-1.1	-1.0	-1.2	-1.5	-0.4
Bipolar Disorder or Schizophrenia	1.0	2.4	4.6	2.1	-2.0	-1.6	-0.9	-1.5	0.1
Depressed Affect (Nagel 2018)	0.1	0.2	0.5	-0.2	-0.0	-0.7	0.3	-0.5	0.1
Depression (Nagel 2018)	0.1	0.2	0.3	0.5	-0.4	-0.5	0.2	-0.4	-0.3
Intelligence (Savage-Jansen 2018)	0.3	0.9	3.4	-0.2	0.8	1.0	-0.1	1.8	0.3
Neuroticism (Nagel 2018)	0.7	1.7	3.4	0.8	-0.8	-1.7	1.2	-1.9	1.2
Schizophrenia (2018)	0.7	1.5	3.5	1.9	-1.7	-1.3	-0.1	-0.7	0.5
Schizophrenia vs Biploar Disorder	0.2	0.2	0.8	0.3	-0.8	-0.1	0.9	0.0	-0.0
Worry (Nagel 2018)	0.7	1.4	2.8	-0.6	-1.4	-1.5	0.9	-1.7	0.4
Alzheimer’s Disease (in mother)	0.4	0.5	1.9	0.4	-0.7	-0.4	1.4	0.3	0.1
Alzheimer’s Disease (in father)	0.2	0.3	0.7	0.6	-0.8	-0.6	0.4	-0.1	0.2
Alzheimer’s Disease (including proxy)	0.7	1.1	3.1	0.5	-1.8	-1.1	1.4	0.3	-0.1
Crohns Disease (2017)	0.7	1.5	5.6	1.1	-0.6	-1.1	0.8	-2.4	0.4
Irritable Bowel Disease (IBD)	1.0	2.5	9.1	-0.1	-1.7	-1.7	0.1	-3.0	-0.1
Ulcerative Colitis (UC)	1.1	2.0	4.7	-0.9	-2.2	-1.4	0.1	-2.1	-0.2
Major Depression (MDD)	0.4	0.4	1.5	-1.2	-0.1	0.7	-0.3	-0.4	-0.6
Reaction Time	0.5	1.0	3.1	-1.5	0.2	-0.4	-0.3	0.4	-1.8
Verbal and Numeric Reasoning (VNR)	0.7	1.7	4.8	-0.5	1.4	1.5	-0.0	2.2	-0.8
Breast Cancer	1.2	2.9	6.9	-1.3	-0.0	2.4	-0.2	2.6	-1.7
Ovarian Cancer	0.7	0.9	2.8	-0.5	0.4	-0.7	-1.7	-0.4	-1.3
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.3	0.5	1.4	0.3	-0.6	0.4	-1.2	0.0	1.0
Bipolar Disorder (2011)	0.9	0.9	2.5	-0.1	-1.6	-1.1	-0.8	-1.0	0.0
Body Mass Index (BMI) (2010)	0.9	1.3	2.4	1.6	1.5	-0.6	0.6	-0.8	1.3
Coronary Artery Disease (CAD)	0.7	0.8	4.0	-0.3	2.0	-0.2	-0.5	0.1	-0.7
Crohns Disease (2012)	0.8	1.4	4.7	1.0	-0.4	-1.1	0.7	-2.2	0.7
Mean Putamen Volume	0.5	0.6	2.1	0.1	-0.2	-0.1	0.4	1.2	1.4
Fasting Glucose	0.4	0.5	1.0	0.9	-0.4	-0.2	0.7	-1.0	0.8
HbA1C	1.0	1.1	3.1	0.3	1.3	1.8	0.5	1.3	0.1
HDL Cholesterol	0.2	0.3	0.6	-0.8	0.3	0.6	0.5	0.8	-0.1
LDL Cholesterol	0.2	0.4	1.4	0.7	0.0	0.7	-0.3	0.1	1.2
Lupus	0.5	0.8	2.8	0.8	0.5	-0.4	-1.7	-0.1	-1.0
Neuroticism (2016)	2.6	3.8	5.9	2.4	-2.3	-2.3	1.6	-1.3	1.4
Primary Biliary Cirrhosis	0.2	0.3	0.8	0.8	-0.3	0.5	0.9	0.0	-0.1
Rheumatoid Arthritis	0.9	1.2	2.6	0.1	0.4	1.4	1.6	1.5	0.0
Schizophrenia (2014)	0.9	2.0	4.1	2.0	-1.6	-1.7	0.3	-1.4	0.3
Triglycerides	0.6	1.0	3.6	1.9	0.7	0.2	-0.3	0.5	1.4
Type 2 Diabetes (T2D) (2012)	0.5	0.5	1.0	0.8	-0.3	-0.4	0.8	-1.0	0.9
Ulcerative Colitis	0.5	0.7	1.6	-0.4	-1.2	-1.1	0.2	-1.0	-0.0
Blood Eosinophil Count	0.1	0.7	1.7	-1.3	0.8	1.1	0.3	0.9	-0.1
Blood Platelet Count	0.1	0.9	3.6	-1.9	-0.6	0.2	-0.4	0.4	-0.9
Blood Red Count	0.3	2.5	5.2	-1.8	-0.5	-2.2	-1.1	-2.3	0.1
Blood White Count	0.5	3.5	8.3	-2.9	-1.5	-1.6	-0.6	-2.1	-1.8
Heel T-Score	9.7	77.0	171.6	-1.7	-12.8	-13.1	-2.2	-10.9	-0.5
BMI	0.1	0.4	1.0	0.5	1.0	0.5	-0.1	0.7	0.1
Height	0.1	1.1	3.6	-0.7	0.3	-0.5	-1.9	-1.3	-0.3
Waist Hip Ratio (WHR)	0.2	1.0	3.2	1.1	-0.2	-0.3	-1.8	-1.1	0.2
Systolic Blood Pressure	0.7	3.5	5.3	2.0	-1.6	-1.9	1.8	-1.5	2.3
Smoking Status	0.8	2.0	9.7	0.8	-0.6	-0.6	3.1	-0.4	0.8
Allergy or Eczema	0.2	0.6	1.7	0.7	-0.6	0.3	0.7	0.4	1.3
Cardiovascular Disease	0.5	1.7	3.1	0.6	-1.6	-1.2	1.8	-1.3	1.2
Hypothyroidism (self reported)	0.5	1.2	3.4	1.0	0.5	0.8	1.0	0.8	1.8
Respiratory disease	0.5	1.1	3.1	-1.8	1.0	0.5	-1.3	-0.9	-0.2
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.3	-0.7	-1.0	-1.1	0.5	-1.1	-0.3
Lung FEV1/FVC ratio	0.6	3.1	9.1	-0.5	-2.3	-1.4	3.0	-1.3	0.0
Lung FVC	1.4	7.1	24.2	-0.6	-2.6	-4.9	-0.9	-3.2	-0.1
Neuroticism	0.2	0.4	1.0	0.1	0.1	-0.5	1.0	-0.7	1.0
Chronotype (morning person)	0.3	0.6	1.3	0.8	1.1	-1.0	0.1	0.4	0.9
Hair Pigment	0.2	5.0	13.3	-3.5	0.3	1.4	-1.0	1.2	-3.6
Tanning	0.3	3.1	14.4	1.9	-0.8	-0.2	0.1	-0.1	3.8
Hand grip strength (left)	0.3	0.7	1.6	-0.0	1.2	-0.2	-1.2	0.9	-0.4
Number of treatments/medications taken	0.9	1.7	4.0	1.2	0.6	0.2	2.0	-1.3	1.5
Average weekly spirits intake	0.4	0.4	1.0	1.0	0.4	0.2	0.2	0.7	0.9
Sensitivity / hurt feelings	1.3	2.3	5.7	0.8	-1.2	-1.4	2.4	-1.8	0.8
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.7	1.7	-1.1	-1.0	0.9	-0.3	0.5
Hearing difficulty/problems: Yes	0.4	0.6	1.5	1.1	0.6	0.2	1.2	0.5	0.3
Relative age of first facial hair	0.1	0.2	0.5	0.1	-0.3	0.7	-0.2	0.6	-0.3
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	3.4	1.3	1.9	-0.1	-1.0	-0.6	0.8
Ever used hormone-replacement therapy (HRT)	0.6	0.8	3.0	1.0	-0.4	-0.7	-0.1	-0.2	1.7
Ever had hysterectomy (womb removed)	8.3	9.3	16.2	2.1	-3.6	-4.0	-1.0	-4.0	2.5
Systolic blood pressure, automated reading	1.1	3.1	7.3	1.9	-1.4	-1.7	0.6	-1.6	2.7
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	1.6	-1.1	-1.1	-0.6	0.6	-1.2	-0.7
Angina	1.6	2.1	5.5	2.3	1.2	-0.8	-0.3	-1.9	1.2
Medication for hormone replacement therapy	1.3	1.5	5.1	2.3	-0.1	-0.5	1.2	0.0	1.5
Vitamin and mineral supplements	0.1	0.2	0.5	-0.1	-0.7	0.1	-0.5	-0.3	-0.3
Supplements: Zinc	0.4	0.4	1.1	-1.0	-0.3	0.5	0.2	1.1	-0.2
Medication: Co-codamol	0.6	0.7	1.6	-0.9	1.3	0.8	-0.0	0.9	-0.7
Medication: Metformin	2.1	2.9	7.9	0.4	-1.4	-2.8	0.3	-2.7	0.5
Diabetes (father)	0.8	0.9	2.3	1.5	-0.7	-1.2	-0.8	-0.8	0.1
Diabetes (mother)	1.5	1.9	3.5	1.1	1.2	-1.4	0.1	-1.9	1.9
Severe depression (siblings)	1.4	1.6	3.3	-0.1	-1.8	-1.4	-1.0	-1.8	0.0
Pack years adult smoking proportion	0.1	0.1	0.2	0.3	0.1	0.1	-0.5	-0.2	0.4
Impedance of leg (right)	0.2	1.2	3.9	0.7	-2.0	-1.1	-0.4	-1.0	0.7
Leg fat-free mass (left)	0.2	0.8	2.2	-0.2	1.5	0.5	-1.2	0.1	-1.1
Trunk fat percentage	0.0	0.1	0.2	0.5	-0.1	0.1	0.3	-0.3	0.2
Hand grip strength (right)	0.2	0.7	1.3	1.2	1.1	0.0	-0.7	0.8	-0.4
Townsend deprivation index at recruitment	1.0	1.4	3.4	1.9	1.1	0.3	-1.6	0.2	1.2
Current tobacco smoking	0.6	0.9	1.5	-0.2	-1.0	-1.2	1.2	-1.1	0.6
Average weekly fortified wine intake	0.6	0.7	1.6	0.5	-1.2	-1.3	0.2	-0.8	0.5
Maternal smoking around birth	1.7	2.4	4.4	-0.9	2.1	2.0	1.7	1.6	0.2
Fed-up feelings	0.1	0.2	0.5	-0.4	-0.7	-0.4	0.2	-0.2	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	0.8	0.5	0.2	-0.6	-0.9	-0.9	0.1
Relative age voice broke	0.6	0.9	4.4	-2.1	-0.2	0.7	-0.4	0.5	-0.2
Taking other prescription medications	1.5	2.4	9.1	1.1	-1.0	-1.7	0.5	-3.0	0.3
Age when periods started (menarche)	0.3	0.8	2.4	-1.0	-0.8	-0.2	-0.9	0.4	-1.5
Bilateral oophorectomy (both ovaries removed)	8.2	9.5	14.9	2.7	-3.6	-3.9	1.3	-3.9	2.2
Heel bone mineral density (BMD) T-score, automated (left)	8.0	18.1	36.4	-0.4	-5.9	-6.0	-2.7	-5.5	-0.4
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	3.0	1.7	-0.6	-0.9	-1.2	0.9	0.9
Qualifications: CSEs or equivalent	1.6	2.1	4.9	2.2	-1.9	-1.1	-0.2	-0.6	1.6
Serious illness, injury or assault to yourself	1.0	1.2	2.4	1.6	-0.7	-1.2	1.0	-1.3	0.6
High blood pressure	0.6	1.5	3.3	0.5	-1.4	-1.8	0.5	-1.3	1.2
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.5	-0.0	-0.4	1.2	1.1	0.9	0.9
Multivitamins +/- minerals	0.5	0.6	2.7	0.5	1.6	0.2	-0.4	0.5	0.5
Stomach or abdominal pain in last month	0.9	1.1	4.1	-2.0	-0.4	0.7	1.0	1.0	-0.1
Supplements: Glucosamine	0.6	0.8	2.5	0.5	1.6	0.8	0.1	1.1	-0.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.4	0.2	0.4	0.2	0.3	0.6	1.2
Medication: Atenolol	2.0	2.5	7.2	1.1	2.7	1.2	-1.6	0.7	1.4
Medication: Levothyroxine sodium	0.4	0.7	1.7	-0.1	1.1	1.0	-0.2	0.2	1.3
Sitting height	1.3	9.0	19.3	-0.7	-3.9	-4.4	-0.7	-4.3	-0.2
Chronic bronchitis/emphysema (father)	0.6	0.8	2.9	-0.5	-1.7	-0.4	0.9	-0.2	-0.5
High blood pressure (mother)	0.3	0.4	1.2	-1.1	0.7	-0.2	-0.5	0.0	-0.9
Body mass index (BMI)	0.1	0.6	2.1	0.1	1.4	0.9	-0.5	0.7	-0.1
Impedance of leg (left)	0.4	1.9	7.5	0.4	-2.7	-1.5	0.3	-0.8	0.7
Leg predicted mass (left)	0.2	0.8	2.0	-0.2	1.4	0.4	-1.2	-0.1	-1.1
Trunk fat mass	0.0	0.1	0.3	0.5	0.2	-0.1	-0.0	-0.3	0.1
Waist circumference	0.1	0.4	0.9	0.9	0.6	-0.2	-0.7	-0.6	0.4
Number of incorrect matches in round	0.5	0.9	3.5	-0.4	-0.2	-0.6	-1.0	-0.5	-1.9
Past tobacco smoking	1.0	1.8	5.6	-2.4	-1.7	0.0	-0.7	-0.5	-1.3
Alcohol usually taken with meals	0.3	0.5	1.8	1.4	0.0	0.4	0.1	-0.1	0.8
Nervous feelings	0.4	0.8	2.2	0.6	-0.6	-1.0	-0.6	-1.5	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.6	1.0	-0.7	-0.9	-0.2	-1.6	0.8
Hearing difficulty/problems with background noise	1.3	2.1	6.1	2.5	1.4	-0.0	-0.3	0.2	2.0
Hair/balding pattern: Pattern 2	1.7	2.1	3.8	-1.3	1.9	1.6	-1.6	1.0	-1.0
Had menopause	0.4	0.5	1.1	-0.9	0.2	1.1	-0.3	0.8	-0.7
Had other major operations	0.7	0.8	3.0	-0.4	1.7	1.3	-0.1	0.5	0.2
Forced vital capacity (FVC)	1.3	5.0	14.8	0.7	-2.1	-3.9	-0.5	-3.2	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	8.3	19.1	39.6	-0.6	-5.7	-6.3	-1.9	-6.2	-0.3
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	2.8	0.9	-1.7	-1.5	1.4	-1.6	0.6
Qualifications: None of the above	0.1	0.3	1.0	-1.0	-0.1	-0.3	0.5	-0.6	0.3
Financial difficulties in last 2 years	1.5	2.1	4.7	2.2	-0.6	-1.0	1.8	-1.2	1.3
Mouth/teeth dental problems	0.4	0.5	1.5	-1.1	-0.4	1.2	-0.4	0.3	-0.2
Heart attack	0.9	1.2	3.5	1.4	1.9	0.8	0.3	0.1	1.0
Allergy	0.4	1.0	3.3	0.3	-0.9	-1.8	0.1	-0.8	-1.1
Pain all over the body in last month	0.3	0.4	1.8	0.3	0.3	0.0	-0.5	-1.3	-0.1
Diabetes (self-reported)	0.8	1.2	2.9	0.4	-0.8	-1.7	1.0	-1.5	0.6
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	5.1	0.8	-0.1	2.3	1.8	1.7	0.2
Medication: Ramipril	0.6	0.7	2.8	-0.5	0.0	-0.9	-1.7	-0.6	-0.3
Medication: Simvastatin	0.6	0.9	2.3	0.1	-0.8	-0.9	0.7	-1.5	1.0
Fluid intelligence score	0.8	1.6	4.0	-0.1	1.7	1.6	-0.5	2.0	-0.7
Illnesses of siblings	0.4	0.6	1.3	-0.2	-0.0	-1.0	-0.4	-1.0	-1.1
Neuroticism score	1.1	2.4	3.3	1.2	-1.4	-1.7	1.6	-1.8	1.5
Weight	0.1	0.3	1.1	0.3	0.8	-0.1	-1.0	-0.3	-0.1
Impedance of arm (right)	0.1	0.4	1.0	0.5	-1.0	0.5	-0.1	-0.3	-1.0
Arm fat percentage (right)	0.1	0.3	0.5	0.1	0.7	0.7	-0.0	0.6	-0.4
Trunk fat-free mass	0.1	0.5	1.6	0.6	0.5	-0.9	-1.3	-0.4	-0.0
Hip circumference	0.1	0.5	1.1	0.4	1.1	0.5	-0.7	0.2	-0.8
Time employed in main current job	0.8	0.9	2.1	0.2	-0.9	-1.4	0.1	-0.9	1.3
Alcohol intake versus 10 years previously	0.7	1.1	2.6	0.4	1.6	0.9	-0.9	1.4	-0.2
Father’s age at death	0.2	0.2	0.4	-0.6	-0.3	-0.4	-0.6	-0.6	0.0
Worrier / anxious feelings	1.9	3.5	6.9	0.8	-2.2	-1.4	2.6	-2.1	1.5
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.2	4.9	2.0	-1.9	-1.3	0.7	-2.1	2.2
Falls in the last year	0.5	0.7	1.7	-0.6	0.4	0.4	-1.3	-0.9	-1.0
Hair/balding pattern: Pattern 3	1.4	2.0	6.9	2.6	0.3	-0.9	1.2	0.2	1.7
Number of live births	0.2	0.3	0.9	0.1	0.9	-0.0	1.0	-0.2	0.5
Forced expiratory volume in 1-second (FEV1)	1.0	3.2	9.7	-0.2	-1.9	-3.1	0.3	-2.4	-0.5
Pulse rate	0.9	1.4	3.9	-0.3	-2.0	-1.7	0.3	-1.3	-0.3
Happiness	0.5	0.6	1.9	0.2	0.0	0.9	0.7	1.4	-0.6
Noisy workplace	1.5	1.9	6.8	-1.0	-1.5	-0.2	2.6	-0.5	-1.1
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.4	0.5	1.0	1.2	-0.1	0.8	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.6	-0.7	0.4	0.8	-0.0	0.0	0.1
Mouth/teeth dental problems: Dentures	0.2	0.4	1.6	0.0	0.1	-1.3	0.2	-0.7	0.6
Asthma	0.7	1.3	2.4	-1.5	1.4	1.1	-1.4	-0.5	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.9	-0.7	-0.5	0.9	1.3	1.4	-0.6
Medication: Cholesterol lowering	0.7	1.2	2.6	1.6	-0.1	-1.2	-0.1	-1.5	0.9
Depression (self-reported)	0.3	0.4	1.4	-0.2	-0.4	0.8	-1.2	0.3	-0.4
Medication: Lansoprazole	0.6	0.7	1.4	0.0	0.9	-0.9	-1.0	-0.4	-1.2
Prospective memory result	0.5	0.6	2.0	0.7	-1.4	-0.2	1.1	-0.3	0.1
Lung cancer (father)	0.8	0.9	2.6	-1.6	-0.7	0.4	-0.8	0.8	-0.9
Illnesses of mother	0.6	0.7	2.0	0.8	-1.4	-0.8	0.9	-0.3	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.4	6.9	-0.7	-1.7	-2.6	0.7	-1.8	-0.6
Pulse wave Arterial Stiffness index	0.4	0.4	0.8	-0.8	0.8	0.2	-0.5	0.6	0.9
Impedance of arm (left)	0.1	0.4	0.8	0.8	-0.6	0.9	0.4	-0.3	-0.6
Arm fat mass (right)	0.0	0.2	0.4	0.2	0.6	0.4	-0.3	0.4	-0.3
Trunk predicted mass	0.1	0.6	1.7	0.6	0.5	-0.9	-1.3	-0.4	-0.0
Standing height	0.2	1.5	2.9	0.3	-1.1	-1.7	-1.4	-1.7	-0.3
Length of working week for main job	2.8	3.1	8.5	-2.0	0.3	1.6	-0.2	1.9	-2.9
Exposure to tobacco smoke at home	0.5	0.5	2.0	0.1	0.2	-0.9	1.4	-0.1	0.6
Breastfed as a baby	0.8	1.0	1.8	-0.6	-0.6	1.1	-0.9	1.1	-1.3
Tense / ‘highly strung’	1.4	2.3	5.2	-0.6	-2.0	-2.3	0.4	-2.0	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.6	0.8	-0.6	-0.3	-0.7	-0.5	0.3
Hair/balding pattern: Pattern 4	0.7	1.7	4.5	-1.5	-0.2	-0.4	-1.6	-0.6	-2.1
Birth weight of first child	0.4	0.7	2.0	0.6	0.7	0.2	1.4	0.4	-1.1
Peak expiratory flow (PEF)	0.1	0.3	1.0	0.3	-0.7	-1.0	-0.3	-0.5	0.3
Pulse wave reflection index	1.0	1.2	3.3	0.4	1.2	-0.8	-1.4	0.3	1.8
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.0	1.1	0.6	0.2	-1.4	-0.4	0.4
Loud music exposure frequency	0.3	0.3	0.4	0.4	0.4	0.6	-0.6	0.6	-0.4
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	2.0	-0.5	1.2	1.1	-0.6	1.4	-0.6
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.3	-0.4	-0.3	0.4	-0.8	1.1	-0.1
Blood clot in the leg (DVT)	0.5	0.6	2.0	-0.5	1.4	0.9	-0.5	-0.4	0.3
Medication: Paracetamol	0.3	0.5	1.4	-1.2	0.3	0.3	0.1	0.3	-1.1
Headache pain in last month	0.2	0.3	0.6	-0.4	-0.8	0.1	0.7	-0.7	0.5
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	3.3	-1.0	1.2	1.8	-0.3	1.6	-0.6
Glaucoma (self-reported)	0.3	0.4	1.1	0.8	-0.6	-1.1	0.3	-0.2	-0.0
Gout (self-reported)	0.3	0.5	0.9	-0.5	0.2	-0.9	-0.9	-0.6	-0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.8	0.0	0.7	0.9	0.5	0.4	0.7
Medication: Amlodipine	2.1	3.0	4.5	1.5	-1.5	-2.1	1.0	-2.0	2.1
Medication: Ventolin 100micrograms inhaler	0.3	0.3	1.0	-1.0	-0.6	-0.0	0.5	-0.6	-0.1
Birth weight	0.4	0.8	3.2	1.1	-0.4	0.3	1.8	0.4	-0.0
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.8	0.4	-0.9	0.3	0.6	1.3	-0.4
High blood pressure (siblings)	0.4	0.5	1.1	0.5	-0.9	-0.8	-0.3	-0.4	1.1
Forced vital capacity (FVC), Best measure	1.0	3.8	11.5	-0.0	-2.1	-3.4	0.1	-2.6	-0.4
Body fat percentage	0.0	0.0	0.1	0.3	0.1	0.2	0.3	-0.1	0.2
Leg fat percentage (right)	0.1	0.4	0.8	-0.0	0.9	0.4	-0.9	0.4	0.6
Arm fat-free mass (right)	0.1	0.4	1.3	0.2	0.5	-0.9	-1.1	-0.5	-0.1
Exposure to tobacco smoke outside home	1.2	1.6	5.2	0.8	-0.7	-1.4	1.2	-2.3	0.4
Comparative body size at age 10	0.4	1.2	1.5	-0.8	1.1	1.1	1.2	1.0	-1.1
Number of full brothers	0.5	0.6	1.8	0.1	0.9	1.4	-0.2	0.9	0.4
Worry too long after embarrassment	1.3	2.3	5.7	2.3	0.5	-0.3	2.4	-0.4	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.9	0.2	-1.4	-0.3	-0.4	-1.3	-0.3
Wheeze or whistling in the chest in last year	0.5	0.9	2.3	-0.9	0.9	1.0	-1.5	-0.9	-0.1
Number of children fathered	0.5	0.5	1.6	-0.8	1.3	0.7	-0.3	0.4	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.3	-0.1	0.1	0.4	1.5	1.5	-0.2
Age at first live birth	0.2	0.4	1.2	-0.6	-1.1	-0.1	0.1	-0.4	-0.8
Pulse wave peak to peak time	0.3	0.3	1.0	0.6	-0.6	0.0	0.2	-0.5	-1.0
Health satisfaction	0.5	0.6	1.4	0.9	-1.2	-0.1	1.0	-0.3	0.5
Shortness of breath walking on level ground	0.1	0.1	0.2	-0.2	-0.5	-0.4	0.2	-0.2	-0.1
Qualifications: College or University degree	0.7	2.2	7.1	-0.4	0.8	1.5	-0.5	1.6	-2.7
Eye problems/disorders: None of the above	2.0	2.4	6.5	0.9	1.3	1.7	-0.1	2.5	1.4
Mouth/teeth dental problems: Loose teeth	0.9	1.1	3.8	0.4	-0.6	-1.9	-0.3	-1.2	-0.6
Emphysema/chronic bronchitis	0.9	1.0	1.8	1.2	-1.3	-1.3	-0.8	-0.9	-0.1
Medication for pain relief, constipation, heartburn	0.4	0.6	3.0	0.4	0.7	0.2	-1.7	0.3	0.4
Neck or shoulder pain in last month	1.3	1.9	3.5	1.9	-1.4	-1.7	-0.1	-0.9	1.5
Medication: Blood pressure	0.8	1.4	3.5	0.4	-1.5	-1.9	0.8	-1.3	0.2
Angina (self-reported)	2.1	2.8	7.2	2.7	1.1	-1.1	-0.2	-2.2	1.4
Migraine (self-reported)	0.2	0.3	1.3	0.1	-0.1	-0.5	-0.5	-1.2	-0.1
Medication: Ibuprofen	0.6	0.7	1.7	-0.5	0.4	1.3	0.9	1.1	-0.3
Medication: Allopurinol	0.7	0.9	1.9	-0.7	-0.5	-1.3	0.7	-1.4	-0.6
Medication: Omeprazole	0.9	1.1	4.3	0.0	-1.2	-0.8	2.1	-0.4	0.1
Medication: Seretide 50 evohaler	0.8	0.9	2.9	0.1	-0.4	-1.2	-1.7	-0.9	0.0
Mean time to correctly identify matches	0.4	0.7	1.6	-0.8	-0.7	-1.3	-0.2	-0.8	-0.8
Heart disease (mother)	0.8	1.0	3.0	-0.9	1.7	1.4	-0.2	0.4	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.2	0.5	-0.2	-0.5	1.1	-1.0	-0.2
Whole body fat mass	0.0	0.1	0.2	0.1	0.3	0.1	-0.4	-0.2	-0.3
Leg fat mass (right)	0.1	0.5	1.3	-0.2	1.1	0.7	-0.9	0.5	-0.0
Arm predicted mass (right)	0.1	0.4	1.2	-0.0	0.1	-1.1	-0.9	-0.7	0.0
Pulse rate, automated reading	0.2	0.6	1.3	-0.3	-0.9	-0.4	0.9	-1.2	0.7
Alcohol intake frequency.	0.7	1.6	3.4	-1.6	1.8	1.0	-1.5	0.7	-0.3
Comparative height size at age 10	0.2	0.8	1.7	0.0	1.2	0.9	0.5	1.3	-0.8
Number of full sisters	0.5	0.6	1.1	0.4	0.6	0.7	-1.0	0.9	1.0
Suffer from ‘nerves’	0.1	0.1	0.4	-0.3	-0.1	-0.4	-0.1	-0.2	0.7
Overall health rating	0.7	1.4	3.7	1.9	0.2	-0.0	0.9	-0.9	1.7
Chest pain or discomfort	1.1	1.6	4.8	2.2	1.2	1.0	-0.1	0.2	1.4
Had major operations	2.4	2.8	8.9	1.2	-0.1	-2.2	0.2	-3.0	1.2
Age at last live birth	0.2	0.3	0.8	-0.9	-0.4	0.3	0.7	-0.1	-0.4
Family relationship satisfaction	1.0	1.2	2.5	-1.4	0.1	0.8	-0.8	1.6	-1.1
Leg pain on walking	0.5	0.6	2.4	1.5	-0.2	-0.9	0.6	-0.2	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.3	0.6	0.3	-0.1	-0.7	0.0	1.2
Commuting to job workplace: Car/motor vehicle	1.3	1.5	3.7	0.8	1.2	1.9	-0.1	1.5	0.8
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.2	-0.3	-1.0	-1.1	-0.8	0.2	0.4
Medication: Aspirin	0.8	1.1	2.5	1.2	-0.6	-0.6	1.6	-0.7	1.1
Supplements: Vitamin C	0.3	0.4	1.6	-0.5	0.4	0.3	0.3	1.2	0.5
Knee pain experienced in last month	0.6	1.0	3.2	-0.7	1.8	1.1	-0.8	0.3	-0.0
Hypertension (Self-reported)	0.6	1.7	3.8	0.7	-1.2	-1.9	0.8	-1.4	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.5	0.7	0.3	-0.2	-0.2	-0.3	0.0
Illnesses of father: Heart disease	1.2	1.7	4.9	1.0	0.6	-1.2	0.9	-1.4	2.2
Illnesses of siblings: Diabetes	1.0	1.2	2.0	1.1	1.4	0.8	-1.1	0.5	1.4
Smoking status: Previous	1.1	1.6	3.6	1.9	1.3	-0.0	1.4	0.7	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	4.7	-1.5	0.0	0.3	-0.8	-0.2	-2.2
Whole body fat-free mass	0.1	0.5	1.5	0.1	0.9	-0.5	-1.2	-0.2	-0.5
Leg fat-free mass (right)	0.1	0.7	1.4	-0.5	1.2	0.3	-0.9	0.2	-1.2
Arm fat percentage (left)	0.1	0.5	1.2	0.4	1.0	1.1	0.1	0.7	-0.2
Average weekly red wine intake	1.2	1.8	4.9	1.4	2.2	1.2	-0.2	1.0	1.1
Handedness (chirality/laterality): Left-handed	1.0	1.2	4.5	-2.1	-0.8	0.8	-0.1	0.4	-1.1
Mood swings	0.2	0.4	1.5	0.6	-0.2	-0.5	1.2	-0.2	0.2
Loneliness, isolation	0.2	0.3	0.6	-0.8	0.3	0.7	0.6	0.5	0.4
Long-standing illness, disability or infirmity	1.2	1.8	4.1	2.0	1.5	0.5	-0.6	-1.0	1.6
Ever had bowel cancer screening	2.0	2.3	4.3	0.4	-2.1	-2.1	0.9	-1.7	1.2
Diabetes diagnosed by doctor	1.0	1.7	3.5	0.2	-1.2	-1.9	1.3	-1.8	0.4
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.3	5.0	-2.2	-0.0	0.0	-0.2	0.8	-1.6
Friendships satisfaction	0.4	0.5	1.3	-1.1	-0.1	0.8	-0.6	0.8	-0.2
Qualifications: nursing, teaching	2.2	3.4	4.8	-2.0	1.8	1.7	-1.8	2.2	-1.5
Commuting to job workplace: Walk	1.9	2.0	3.8	1.9	0.1	-1.5	-1.8	-1.4	0.9
Eye problems/disorders: Cataract	1.1	1.3	4.1	-0.7	-0.8	-1.2	0.0	-2.0	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	4.6	2.1	1.1	-0.9	0.6	-1.2	0.2
Medication for cholesterol	0.7	1.1	5.0	-0.7	-0.4	-0.8	-0.7	-0.2	-2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	1.9	1.0	0.5	-0.7	1.4	-0.3	1.1
Back pain experienced in last month	0.3	0.5	2.2	-0.1	-1.5	0.1	0.4	-0.5	-0.6
Mineral and other dietary supplements	0.5	0.7	2.2	-0.3	-1.5	-0.3	-0.8	-1.0	-0.5
Breast cancer (self-reported)	1.0	1.2	2.5	1.6	1.0	1.0	-0.7	0.5	1.4
Asthma (self-reported)	0.5	1.0	1.7	-1.3	1.2	1.2	-1.1	-0.6	-0.2
Osteoporosis (self-reported)	0.6	0.8	2.1	1.3	1.4	-0.1	-0.2	0.0	1.0
Osteoarthritis (self-reported)	0.2	0.3	0.8	0.0	0.5	0.6	-0.9	-0.0	0.4
Medication: Aspirin	1.4	1.8	4.6	1.7	-0.7	-0.9	2.1	-0.9	1.2
Medication: Gliclazide	1.9	2.2	4.5	0.0	-2.1	-1.7	1.3	-2.0	0.1
Illnesses of father: None of the above (group 1)	0.3	0.4	1.7	-0.2	0.4	0.5	-1.3	-0.3	0.5
Smoking status: Current	0.3	0.5	1.0	-0.2	-0.8	-1.0	0.8	-0.9	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.5	0.2	-0.2	-0.7	0.3	-0.3	-0.1
Whole body water mass	0.1	0.5	1.5	0.0	0.8	-0.6	-1.2	-0.3	-0.5
Leg predicted mass (right)	0.1	0.7	1.4	-0.5	1.2	0.3	-1.0	0.2	-1.1
Arm fat mass (left)	0.1	0.3	1.0	0.3	1.0	0.4	-0.5	0.4	-0.2
Number of self-reported non-cancer illnesses	0.1	0.2	0.9	0.4	0.1	0.1	0.6	-1.0	0.0
Average weekly champagne plus white wine intake	0.7	1.0	4.4	0.1	-2.1	-0.7	0.7	-0.8	-0.3
Miserableness	0.8	1.3	2.9	1.5	-0.9	-1.7	0.5	-1.0	0.9
Guilty feelings	1.5	2.3	5.1	2.3	-0.8	-1.3	1.2	-1.6	1.6
Wears glasses or contact lenses	0.7	0.8	3.5	-0.4	-0.7	-0.5	1.9	-0.6	0.4
Ever taken oral contraceptive pill	1.3	1.4	5.3	0.3	-0.4	-1.3	2.3	-1.0	0.7
Hearing aid user	0.9	1.0	2.4	-0.5	1.6	1.3	-0.1	1.4	0.1
Mother’s age at death	0.3	0.4	0.7	0.3	-0.6	-0.2	-0.6	0.8	-0.8
Financial situation satisfaction	0.3	0.4	1.1	-0.7	0.0	0.3	-1.0	0.6	-0.4
Tinnitus: Yes, now most or all of the time	1.6	1.9	4.5	-1.0	-1.6	-1.4	0.5	-1.1	-2.1
Commuting to job workplace: Public transport	0.4	0.5	1.3	-1.2	-0.4	-0.0	-0.3	-0.9	-0.6
Eye problems/disorders: Glaucoma	0.3	0.4	1.5	0.4	-0.5	-1.2	0.3	-0.6	0.1
Medication: Blood pressure	0.2	0.5	1.9	0.6	0.4	0.2	-0.5	-0.2	1.4
Pain type(s) experienced in last month: Hip pain	0.3	0.3	1.8	1.3	-0.2	0.1	-0.3	0.2	0.2
Supplements: Fish oil (including cod liver oil)	0.4	0.5	2.1	-0.3	1.4	0.3	0.7	0.3	0.0
High cholesterol (Self-reported)	0.2	0.3	0.6	-0.4	0.5	0.1	-0.8	-0.8	0.5
Medication: Bendroflumethiazide	1.6	2.4	6.5	2.2	-0.1	-0.9	1.3	-0.6	2.5
Medication: Paracetamol	0.7	1.0	3.7	-1.9	0.1	0.4	1.0	0.1	-1.1
Medication: Lisinopril	0.8	1.0	3.4	-1.8	0.0	0.7	0.4	-0.5	-1.3
Medication: Atorvastatin	0.8	1.0	2.1	1.1	1.5	0.1	0.8	-0.4	1.3
Illnesses of father: High blood pressure	0.8	1.0	2.6	-0.6	-0.3	-1.6	1.2	-1.1	-0.3
Alcohol drinker status: Never	1.0	1.2	2.7	-1.4	-0.6	-1.2	-0.8	-1.6	-0.4
Ever smoked	0.7	1.3	3.8	1.9	1.0	-0.4	0.8	-0.3	1.4
Basal metabolic rate	0.1	0.4	1.2	0.1	0.9	-0.4	-1.1	-0.2	-0.5
Leg fat percentage (left)	0.1	0.2	0.4	-0.2	0.6	0.2	-0.6	0.4	0.5
Arm fat-free mass (left)	0.1	0.7	1.9	-0.2	0.1	-1.2	-1.4	-0.7	-0.1
Number of operations (self-reported)	1.2	1.8	4.8	0.7	-0.1	-1.7	0.5	-2.2	1.4
Average weekly beer plus cider intake	0.4	0.6	1.7	-0.5	-1.3	-0.7	0.7	-0.6	0.3
Irritability	1.3	2.2	5.7	1.2	-0.9	-2.4	0.5	-1.8	1.2
Risk taking	1.8	2.6	5.2	-1.2	1.0	1.4	-2.3	1.7	-1.7
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.0	-0.5	0.6	0.7	0.8	0.2	-1.0
Fractured/broken bones in last 5 years	0.5	0.7	1.3	0.3	0.9	0.6	-0.8	0.9	-1.2
Age started oral contraceptive pill	0.1	0.1	0.5	-0.4	-0.7	-0.1	-0.1	-0.2	0.4
Diastolic blood pressure, automated reading	0.5	1.6	6.2	0.9	-0.8	-0.0	0.9	-1.0	2.5
Ever depressed for a whole week	0.3	0.4	1.0	0.7	-1.0	-0.8	0.5	-0.1	-0.2
Unable to work because of sickness or disability	0.3	0.4	2.1	-0.0	0.3	-0.3	-1.5	-0.2	-0.5
Commuting to job workplace: Cycle	1.2	1.4	3.1	1.8	1.4	0.8	-1.5	-0.1	0.8
Myopia	1.0	1.5	3.6	0.7	-1.4	-1.9	0.8	-1.1	1.0
Vascular/heart problems diagnosed by doctor	0.6	1.8	3.6	-0.6	1.2	1.9	-0.5	1.8	-1.3
Cholesterol lowering medication	0.5	0.7	2.1	-0.3	-0.1	0.4	0.7	-1.1	1.5
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	5.7	-0.4	-0.8	-0.5	2.4	0.0	-0.3
Pain experienced in last month	0.1	0.2	0.5	0.6	-0.2	-0.6	0.7	0.2	-0.5
Supplements: Calcium	1.3	1.4	3.4	1.7	1.9	0.4	-0.8	0.7	1.0
Basal cell carcinoma (self-reported)	2.2	2.6	6.4	1.1	-1.9	-2.5	-0.6	-2.0	-0.6
Heart attack/myocardial infarction (self-reported)	0.9	1.1	4.4	0.9	2.1	0.8	0.3	0.2	0.8
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	2.4	-0.6	1.5	0.7	-0.9	-0.7	0.0
Heart disease (siblings)	0.5	0.6	2.8	0.6	-0.0	0.4	-0.4	0.2	1.7
Alcohol drinker status: Previous	0.5	0.6	1.5	-1.2	0.3	-0.9	-0.5	-1.0	-0.1
Pack years of smoking	0.2	0.2	0.6	0.1	0.4	0.2	-0.8	-0.4	0.6
Impedance of whole body	0.2	0.9	4.0	0.6	-2.0	-0.4	0.3	-0.7	-0.2
Leg fat mass (left)	0.1	0.3	0.9	-0.1	1.0	0.4	-0.8	0.5	0.0
Arm predicted mass (left)	0.1	0.7	2.0	0.0	-0.2	-1.4	-1.2	-0.9	-0.0