Hub : Genes

CD109

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0980 0.0290 1.6e-06 0.018 0.065 0.020 0.063 0.014 2.4e-03 2.2e-08 1.6e-03 4.0e-08 7.0e-03
2 GTEx Artery Aorta 0.3220 0.0640 1.1e-08 0.216 NA 0.231 NA 0.229 4.2e-12 NA 5.9e-13 NA 7.4e-13
3 GTEx Pancreas 0.1810 0.0660 9.7e-04 0.070 NA 0.057 NA 0.074 6.8e-04 NA 2.0e-03 NA 5.0e-04
4 GTEx Skin Not Sun Exposed Suprapubic 0.1710 0.0640 6.3e-04 0.022 NA 0.082 NA 0.069 2.1e-02 NA 2.9e-05 NA 1.3e-04
5 GTEx Spleen 0.2740 0.0900 2.7e-03 0.021 NA 0.013 NA 0.025 9.4e-02 NA 1.4e-01 NA 7.6e-02
6 ROSMAP Brain Pre-frontal Cortex 0.0407 0.0185 3.2e-03 -0.002 0.008 0.008 0.009 -0.002 6.5e-01 2.8e-02 2.6e-02 2.3e-02 6.6e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.8 1.2 2.3 1.1 -1.1 -1.0 -1.2 -1.5 -0.4
Bipolar Disorder or Schizophrenia 1.0 2.4 4.6 2.1 -2.0 -1.6 -0.9 -1.5 0.1
Depressed Affect (Nagel 2018) 0.1 0.2 0.5 -0.2 -0.0 -0.7 0.3 -0.5 0.1
Depression (Nagel 2018) 0.1 0.2 0.3 0.5 -0.4 -0.5 0.2 -0.4 -0.3
Intelligence (Savage-Jansen 2018) 0.3 0.9 3.4 -0.2 0.8 1.0 -0.1 1.8 0.3
Neuroticism (Nagel 2018) 0.7 1.7 3.4 0.8 -0.8 -1.7 1.2 -1.9 1.2
Schizophrenia (2018) 0.7 1.5 3.5 1.9 -1.7 -1.3 -0.1 -0.7 0.5
Schizophrenia vs Biploar Disorder 0.2 0.2 0.8 0.3 -0.8 -0.1 0.9 0.0 -0.0
Worry (Nagel 2018) 0.7 1.4 2.8 -0.6 -1.4 -1.5 0.9 -1.7 0.4
Alzheimer’s Disease (in mother) 0.4 0.5 1.9 0.4 -0.7 -0.4 1.4 0.3 0.1
Alzheimer’s Disease (in father) 0.2 0.3 0.7 0.6 -0.8 -0.6 0.4 -0.1 0.2
Alzheimer’s Disease (including proxy) 0.7 1.1 3.1 0.5 -1.8 -1.1 1.4 0.3 -0.1
Crohns Disease (2017) 0.7 1.5 5.6 1.1 -0.6 -1.1 0.8 -2.4 0.4
Irritable Bowel Disease (IBD) 1.0 2.5 9.1 -0.1 -1.7 -1.7 0.1 -3.0 -0.1
Ulcerative Colitis (UC) 1.1 2.0 4.7 -0.9 -2.2 -1.4 0.1 -2.1 -0.2
Major Depression (MDD) 0.4 0.4 1.5 -1.2 -0.1 0.7 -0.3 -0.4 -0.6
Reaction Time 0.5 1.0 3.1 -1.5 0.2 -0.4 -0.3 0.4 -1.8
Verbal and Numeric Reasoning (VNR) 0.7 1.7 4.8 -0.5 1.4 1.5 -0.0 2.2 -0.8
Breast Cancer 1.2 2.9 6.9 -1.3 -0.0 2.4 -0.2 2.6 -1.7
Ovarian Cancer 0.7 0.9 2.8 -0.5 0.4 -0.7 -1.7 -0.4 -1.3
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.3 0.5 1.4 0.3 -0.6 0.4 -1.2 0.0 1.0
Bipolar Disorder (2011) 0.9 0.9 2.5 -0.1 -1.6 -1.1 -0.8 -1.0 0.0
Body Mass Index (BMI) (2010) 0.9 1.3 2.4 1.6 1.5 -0.6 0.6 -0.8 1.3
Coronary Artery Disease (CAD) 0.7 0.8 4.0 -0.3 2.0 -0.2 -0.5 0.1 -0.7
Crohns Disease (2012) 0.8 1.4 4.7 1.0 -0.4 -1.1 0.7 -2.2 0.7
Mean Putamen Volume 0.5 0.6 2.1 0.1 -0.2 -0.1 0.4 1.2 1.4
Fasting Glucose 0.4 0.5 1.0 0.9 -0.4 -0.2 0.7 -1.0 0.8
HbA1C 1.0 1.1 3.1 0.3 1.3 1.8 0.5 1.3 0.1
HDL Cholesterol 0.2 0.3 0.6 -0.8 0.3 0.6 0.5 0.8 -0.1
LDL Cholesterol 0.2 0.4 1.4 0.7 0.0 0.7 -0.3 0.1 1.2
Lupus 0.5 0.8 2.8 0.8 0.5 -0.4 -1.7 -0.1 -1.0
Neuroticism (2016) 2.6 3.8 5.9 2.4 -2.3 -2.3 1.6 -1.3 1.4
Primary Biliary Cirrhosis 0.2 0.3 0.8 0.8 -0.3 0.5 0.9 0.0 -0.1
Rheumatoid Arthritis 0.9 1.2 2.6 0.1 0.4 1.4 1.6 1.5 0.0
Schizophrenia (2014) 0.9 2.0 4.1 2.0 -1.6 -1.7 0.3 -1.4 0.3
Triglycerides 0.6 1.0 3.6 1.9 0.7 0.2 -0.3 0.5 1.4
Type 2 Diabetes (T2D) (2012) 0.5 0.5 1.0 0.8 -0.3 -0.4 0.8 -1.0 0.9
Ulcerative Colitis 0.5 0.7 1.6 -0.4 -1.2 -1.1 0.2 -1.0 -0.0
Blood Eosinophil Count 0.1 0.7 1.7 -1.3 0.8 1.1 0.3 0.9 -0.1
Blood Platelet Count 0.1 0.9 3.6 -1.9 -0.6 0.2 -0.4 0.4 -0.9
Blood Red Count 0.3 2.5 5.2 -1.8 -0.5 -2.2 -1.1 -2.3 0.1
Blood White Count 0.5 3.5 8.3 -2.9 -1.5 -1.6 -0.6 -2.1 -1.8
Heel T-Score 9.7 77.0 171.6 -1.7 -12.8 -13.1 -2.2 -10.9 -0.5
BMI 0.1 0.4 1.0 0.5 1.0 0.5 -0.1 0.7 0.1
Height 0.1 1.1 3.6 -0.7 0.3 -0.5 -1.9 -1.3 -0.3
Waist Hip Ratio (WHR) 0.2 1.0 3.2 1.1 -0.2 -0.3 -1.8 -1.1 0.2
Systolic Blood Pressure 0.7 3.5 5.3 2.0 -1.6 -1.9 1.8 -1.5 2.3
Smoking Status 0.8 2.0 9.7 0.8 -0.6 -0.6 3.1 -0.4 0.8
Allergy or Eczema 0.2 0.6 1.7 0.7 -0.6 0.3 0.7 0.4 1.3
Cardiovascular Disease 0.5 1.7 3.1 0.6 -1.6 -1.2 1.8 -1.3 1.2
Hypothyroidism (self reported) 0.5 1.2 3.4 1.0 0.5 0.8 1.0 0.8 1.8
Respiratory disease 0.5 1.1 3.1 -1.8 1.0 0.5 -1.3 -0.9 -0.2
Type 2 Diabetes (T2D) (2018) 0.4 0.7 1.3 -0.7 -1.0 -1.1 0.5 -1.1 -0.3
Lung FEV1/FVC ratio 0.6 3.1 9.1 -0.5 -2.3 -1.4 3.0 -1.3 0.0
Lung FVC 1.4 7.1 24.2 -0.6 -2.6 -4.9 -0.9 -3.2 -0.1
Neuroticism 0.2 0.4 1.0 0.1 0.1 -0.5 1.0 -0.7 1.0
Chronotype (morning person) 0.3 0.6 1.3 0.8 1.1 -1.0 0.1 0.4 0.9
Hair Pigment 0.2 5.0 13.3 -3.5 0.3 1.4 -1.0 1.2 -3.6
Tanning 0.3 3.1 14.4 1.9 -0.8 -0.2 0.1 -0.1 3.8
Hand grip strength (left) 0.3 0.7 1.6 -0.0 1.2 -0.2 -1.2 0.9 -0.4
Number of treatments/medications taken 0.9 1.7 4.0 1.2 0.6 0.2 2.0 -1.3 1.5
Average weekly spirits intake 0.4 0.4 1.0 1.0 0.4 0.2 0.2 0.7 0.9
Sensitivity / hurt feelings 1.3 2.3 5.7 0.8 -1.2 -1.4 2.4 -1.8 0.8
Frequency of depressed mood in last 2 weeks 0.8 1.1 2.7 1.7 -1.1 -1.0 0.9 -0.3 0.5
Hearing difficulty/problems: Yes 0.4 0.6 1.5 1.1 0.6 0.2 1.2 0.5 0.3
Relative age of first facial hair 0.1 0.2 0.5 0.1 -0.3 0.7 -0.2 0.6 -0.3
Other serious medical condition/disability diagnosed by doctor 0.9 1.2 3.4 1.3 1.9 -0.1 -1.0 -0.6 0.8
Ever used hormone-replacement therapy (HRT) 0.6 0.8 3.0 1.0 -0.4 -0.7 -0.1 -0.2 1.7
Ever had hysterectomy (womb removed) 8.3 9.3 16.2 2.1 -3.6 -4.0 -1.0 -4.0 2.5
Systolic blood pressure, automated reading 1.1 3.1 7.3 1.9 -1.4 -1.7 0.6 -1.6 2.7
Eye problems/disorders: Diabetes related eye disease 0.8 0.8 1.6 -1.1 -1.1 -0.6 0.6 -1.2 -0.7
Angina 1.6 2.1 5.5 2.3 1.2 -0.8 -0.3 -1.9 1.2
Medication for hormone replacement therapy 1.3 1.5 5.1 2.3 -0.1 -0.5 1.2 0.0 1.5
Vitamin and mineral supplements 0.1 0.2 0.5 -0.1 -0.7 0.1 -0.5 -0.3 -0.3
Supplements: Zinc 0.4 0.4 1.1 -1.0 -0.3 0.5 0.2 1.1 -0.2
Medication: Co-codamol 0.6 0.7 1.6 -0.9 1.3 0.8 -0.0 0.9 -0.7
Medication: Metformin 2.1 2.9 7.9 0.4 -1.4 -2.8 0.3 -2.7 0.5
Diabetes (father) 0.8 0.9 2.3 1.5 -0.7 -1.2 -0.8 -0.8 0.1
Diabetes (mother) 1.5 1.9 3.5 1.1 1.2 -1.4 0.1 -1.9 1.9
Severe depression (siblings) 1.4 1.6 3.3 -0.1 -1.8 -1.4 -1.0 -1.8 0.0
Pack years adult smoking proportion 0.1 0.1 0.2 0.3 0.1 0.1 -0.5 -0.2 0.4
Impedance of leg (right) 0.2 1.2 3.9 0.7 -2.0 -1.1 -0.4 -1.0 0.7
Leg fat-free mass (left) 0.2 0.8 2.2 -0.2 1.5 0.5 -1.2 0.1 -1.1
Trunk fat percentage 0.0 0.1 0.2 0.5 -0.1 0.1 0.3 -0.3 0.2
Hand grip strength (right) 0.2 0.7 1.3 1.2 1.1 0.0 -0.7 0.8 -0.4
Townsend deprivation index at recruitment 1.0 1.4 3.4 1.9 1.1 0.3 -1.6 0.2 1.2
Current tobacco smoking 0.6 0.9 1.5 -0.2 -1.0 -1.2 1.2 -1.1 0.6
Average weekly fortified wine intake 0.6 0.7 1.6 0.5 -1.2 -1.3 0.2 -0.8 0.5
Maternal smoking around birth 1.7 2.4 4.4 -0.9 2.1 2.0 1.7 1.6 0.2
Fed-up feelings 0.1 0.2 0.5 -0.4 -0.7 -0.4 0.2 -0.2 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.3 0.8 0.5 0.2 -0.6 -0.9 -0.9 0.1
Relative age voice broke 0.6 0.9 4.4 -2.1 -0.2 0.7 -0.4 0.5 -0.2
Taking other prescription medications 1.5 2.4 9.1 1.1 -1.0 -1.7 0.5 -3.0 0.3
Age when periods started (menarche) 0.3 0.8 2.4 -1.0 -0.8 -0.2 -0.9 0.4 -1.5
Bilateral oophorectomy (both ovaries removed) 8.2 9.5 14.9 2.7 -3.6 -3.9 1.3 -3.9 2.2
Heel bone mineral density (BMD) T-score, automated (left) 8.0 18.1 36.4 -0.4 -5.9 -6.0 -2.7 -5.5 -0.4
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 3.0 1.7 -0.6 -0.9 -1.2 0.9 0.9
Qualifications: CSEs or equivalent 1.6 2.1 4.9 2.2 -1.9 -1.1 -0.2 -0.6 1.6
Serious illness, injury or assault to yourself 1.0 1.2 2.4 1.6 -0.7 -1.2 1.0 -1.3 0.6
High blood pressure 0.6 1.5 3.3 0.5 -1.4 -1.8 0.5 -1.3 1.2
Hayfever, allergic rhinitis or eczema 0.4 0.8 1.5 -0.0 -0.4 1.2 1.1 0.9 0.9
Multivitamins +/- minerals 0.5 0.6 2.7 0.5 1.6 0.2 -0.4 0.5 0.5
Stomach or abdominal pain in last month 0.9 1.1 4.1 -2.0 -0.4 0.7 1.0 1.0 -0.1
Supplements: Glucosamine 0.6 0.8 2.5 0.5 1.6 0.8 0.1 1.1 -0.1
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 1.4 0.2 0.4 0.2 0.3 0.6 1.2
Medication: Atenolol 2.0 2.5 7.2 1.1 2.7 1.2 -1.6 0.7 1.4
Medication: Levothyroxine sodium 0.4 0.7 1.7 -0.1 1.1 1.0 -0.2 0.2 1.3
Sitting height 1.3 9.0 19.3 -0.7 -3.9 -4.4 -0.7 -4.3 -0.2
Chronic bronchitis/emphysema (father) 0.6 0.8 2.9 -0.5 -1.7 -0.4 0.9 -0.2 -0.5
High blood pressure (mother) 0.3 0.4 1.2 -1.1 0.7 -0.2 -0.5 0.0 -0.9
Body mass index (BMI) 0.1 0.6 2.1 0.1 1.4 0.9 -0.5 0.7 -0.1
Impedance of leg (left) 0.4 1.9 7.5 0.4 -2.7 -1.5 0.3 -0.8 0.7
Leg predicted mass (left) 0.2 0.8 2.0 -0.2 1.4 0.4 -1.2 -0.1 -1.1
Trunk fat mass 0.0 0.1 0.3 0.5 0.2 -0.1 -0.0 -0.3 0.1
Waist circumference 0.1 0.4 0.9 0.9 0.6 -0.2 -0.7 -0.6 0.4
Number of incorrect matches in round 0.5 0.9 3.5 -0.4 -0.2 -0.6 -1.0 -0.5 -1.9
Past tobacco smoking 1.0 1.8 5.6 -2.4 -1.7 0.0 -0.7 -0.5 -1.3
Alcohol usually taken with meals 0.3 0.5 1.8 1.4 0.0 0.4 0.1 -0.1 0.8
Nervous feelings 0.4 0.8 2.2 0.6 -0.6 -1.0 -0.6 -1.5 0.8
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 2.6 1.0 -0.7 -0.9 -0.2 -1.6 0.8
Hearing difficulty/problems with background noise 1.3 2.1 6.1 2.5 1.4 -0.0 -0.3 0.2 2.0
Hair/balding pattern: Pattern 2 1.7 2.1 3.8 -1.3 1.9 1.6 -1.6 1.0 -1.0
Had menopause 0.4 0.5 1.1 -0.9 0.2 1.1 -0.3 0.8 -0.7
Had other major operations 0.7 0.8 3.0 -0.4 1.7 1.3 -0.1 0.5 0.2
Forced vital capacity (FVC) 1.3 5.0 14.8 0.7 -2.1 -3.9 -0.5 -3.2 -0.2
Heel bone mineral density (BMD) T-score, automated (right) 8.3 19.1 39.6 -0.6 -5.7 -6.3 -1.9 -6.2 -0.3
Ever unenthusiastic/disinterested for a whole week 1.5 1.8 2.8 0.9 -1.7 -1.5 1.4 -1.6 0.6
Qualifications: None of the above 0.1 0.3 1.0 -1.0 -0.1 -0.3 0.5 -0.6 0.3
Financial difficulties in last 2 years 1.5 2.1 4.7 2.2 -0.6 -1.0 1.8 -1.2 1.3
Mouth/teeth dental problems 0.4 0.5 1.5 -1.1 -0.4 1.2 -0.4 0.3 -0.2
Heart attack 0.9 1.2 3.5 1.4 1.9 0.8 0.3 0.1 1.0
Allergy 0.4 1.0 3.3 0.3 -0.9 -1.8 0.1 -0.8 -1.1
Pain all over the body in last month 0.3 0.4 1.8 0.3 0.3 0.0 -0.5 -1.3 -0.1
Diabetes (self-reported) 0.8 1.2 2.9 0.4 -0.8 -1.7 1.0 -1.5 0.6
Hayfever/allergic rhinitis (self-reported) 1.5 2.0 5.1 0.8 -0.1 2.3 1.8 1.7 0.2
Medication: Ramipril 0.6 0.7 2.8 -0.5 0.0 -0.9 -1.7 -0.6 -0.3
Medication: Simvastatin 0.6 0.9 2.3 0.1 -0.8 -0.9 0.7 -1.5 1.0
Fluid intelligence score 0.8 1.6 4.0 -0.1 1.7 1.6 -0.5 2.0 -0.7
Illnesses of siblings 0.4 0.6 1.3 -0.2 -0.0 -1.0 -0.4 -1.0 -1.1
Neuroticism score 1.1 2.4 3.3 1.2 -1.4 -1.7 1.6 -1.8 1.5
Weight 0.1 0.3 1.1 0.3 0.8 -0.1 -1.0 -0.3 -0.1
Impedance of arm (right) 0.1 0.4 1.0 0.5 -1.0 0.5 -0.1 -0.3 -1.0
Arm fat percentage (right) 0.1 0.3 0.5 0.1 0.7 0.7 -0.0 0.6 -0.4
Trunk fat-free mass 0.1 0.5 1.6 0.6 0.5 -0.9 -1.3 -0.4 -0.0
Hip circumference 0.1 0.5 1.1 0.4 1.1 0.5 -0.7 0.2 -0.8
Time employed in main current job 0.8 0.9 2.1 0.2 -0.9 -1.4 0.1 -0.9 1.3
Alcohol intake versus 10 years previously 0.7 1.1 2.6 0.4 1.6 0.9 -0.9 1.4 -0.2
Father’s age at death 0.2 0.2 0.4 -0.6 -0.3 -0.4 -0.6 -0.6 0.0
Worrier / anxious feelings 1.9 3.5 6.9 0.8 -2.2 -1.4 2.6 -2.1 1.5
Frequency of tiredness / lethargy in last 2 weeks 2.0 3.2 4.9 2.0 -1.9 -1.3 0.7 -2.1 2.2
Falls in the last year 0.5 0.7 1.7 -0.6 0.4 0.4 -1.3 -0.9 -1.0
Hair/balding pattern: Pattern 3 1.4 2.0 6.9 2.6 0.3 -0.9 1.2 0.2 1.7
Number of live births 0.2 0.3 0.9 0.1 0.9 -0.0 1.0 -0.2 0.5
Forced expiratory volume in 1-second (FEV1) 1.0 3.2 9.7 -0.2 -1.9 -3.1 0.3 -2.4 -0.5
Pulse rate 0.9 1.4 3.9 -0.3 -2.0 -1.7 0.3 -1.3 -0.3
Happiness 0.5 0.6 1.9 0.2 0.0 0.9 0.7 1.4 -0.6
Noisy workplace 1.5 1.9 6.8 -1.0 -1.5 -0.2 2.6 -0.5 -1.1
Qualifications: A levels/AS levels or equivalent 0.3 0.6 1.4 0.5 1.0 1.2 -0.1 0.8 0.5
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.6 -0.7 0.4 0.8 -0.0 0.0 0.1
Mouth/teeth dental problems: Dentures 0.2 0.4 1.6 0.0 0.1 -1.3 0.2 -0.7 0.6
Asthma 0.7 1.3 2.4 -1.5 1.4 1.1 -1.4 -0.5 -0.3
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 1.9 -0.7 -0.5 0.9 1.3 1.4 -0.6
Medication: Cholesterol lowering 0.7 1.2 2.6 1.6 -0.1 -1.2 -0.1 -1.5 0.9
Depression (self-reported) 0.3 0.4 1.4 -0.2 -0.4 0.8 -1.2 0.3 -0.4
Medication: Lansoprazole 0.6 0.7 1.4 0.0 0.9 -0.9 -1.0 -0.4 -1.2
Prospective memory result 0.5 0.6 2.0 0.7 -1.4 -0.2 1.1 -0.3 0.1
Lung cancer (father) 0.8 0.9 2.6 -1.6 -0.7 0.4 -0.8 0.8 -0.9
Illnesses of mother 0.6 0.7 2.0 0.8 -1.4 -0.8 0.9 -0.3 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.4 6.9 -0.7 -1.7 -2.6 0.7 -1.8 -0.6
Pulse wave Arterial Stiffness index 0.4 0.4 0.8 -0.8 0.8 0.2 -0.5 0.6 0.9
Impedance of arm (left) 0.1 0.4 0.8 0.8 -0.6 0.9 0.4 -0.3 -0.6
Arm fat mass (right) 0.0 0.2 0.4 0.2 0.6 0.4 -0.3 0.4 -0.3
Trunk predicted mass 0.1 0.6 1.7 0.6 0.5 -0.9 -1.3 -0.4 -0.0
Standing height 0.2 1.5 2.9 0.3 -1.1 -1.7 -1.4 -1.7 -0.3
Length of working week for main job 2.8 3.1 8.5 -2.0 0.3 1.6 -0.2 1.9 -2.9
Exposure to tobacco smoke at home 0.5 0.5 2.0 0.1 0.2 -0.9 1.4 -0.1 0.6
Breastfed as a baby 0.8 1.0 1.8 -0.6 -0.6 1.1 -0.9 1.1 -1.3
Tense / ‘highly strung’ 1.4 2.3 5.2 -0.6 -2.0 -2.3 0.4 -2.0 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.6 0.8 -0.6 -0.3 -0.7 -0.5 0.3
Hair/balding pattern: Pattern 4 0.7 1.7 4.5 -1.5 -0.2 -0.4 -1.6 -0.6 -2.1
Birth weight of first child 0.4 0.7 2.0 0.6 0.7 0.2 1.4 0.4 -1.1
Peak expiratory flow (PEF) 0.1 0.3 1.0 0.3 -0.7 -1.0 -0.3 -0.5 0.3
Pulse wave reflection index 1.0 1.2 3.3 0.4 1.2 -0.8 -1.4 0.3 1.8
Ever highly irritable/argumentative for 2 days 0.6 0.7 2.0 1.1 0.6 0.2 -1.4 -0.4 0.4
Loud music exposure frequency 0.3 0.3 0.4 0.4 0.4 0.6 -0.6 0.6 -0.4
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 2.0 -0.5 1.2 1.1 -0.6 1.4 -0.6
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.3 -0.4 -0.3 0.4 -0.8 1.1 -0.1
Blood clot in the leg (DVT) 0.5 0.6 2.0 -0.5 1.4 0.9 -0.5 -0.4 0.3
Medication: Paracetamol 0.3 0.5 1.4 -1.2 0.3 0.3 0.1 0.3 -1.1
Headache pain in last month 0.2 0.3 0.6 -0.4 -0.8 0.1 0.7 -0.7 0.5
Medication for cholesterol, blood pressure or diabetes 0.9 1.4 3.3 -1.0 1.2 1.8 -0.3 1.6 -0.6
Glaucoma (self-reported) 0.3 0.4 1.1 0.8 -0.6 -1.1 0.3 -0.2 -0.0
Gout (self-reported) 0.3 0.5 0.9 -0.5 0.2 -0.9 -0.9 -0.6 -0.8
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.8 0.0 0.7 0.9 0.5 0.4 0.7
Medication: Amlodipine 2.1 3.0 4.5 1.5 -1.5 -2.1 1.0 -2.0 2.1
Medication: Ventolin 100micrograms inhaler 0.3 0.3 1.0 -1.0 -0.6 -0.0 0.5 -0.6 -0.1
Birth weight 0.4 0.8 3.2 1.1 -0.4 0.3 1.8 0.4 -0.0
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.8 0.4 -0.9 0.3 0.6 1.3 -0.4
High blood pressure (siblings) 0.4 0.5 1.1 0.5 -0.9 -0.8 -0.3 -0.4 1.1
Forced vital capacity (FVC), Best measure 1.0 3.8 11.5 -0.0 -2.1 -3.4 0.1 -2.6 -0.4
Body fat percentage 0.0 0.0 0.1 0.3 0.1 0.2 0.3 -0.1 0.2
Leg fat percentage (right) 0.1 0.4 0.8 -0.0 0.9 0.4 -0.9 0.4 0.6
Arm fat-free mass (right) 0.1 0.4 1.3 0.2 0.5 -0.9 -1.1 -0.5 -0.1
Exposure to tobacco smoke outside home 1.2 1.6 5.2 0.8 -0.7 -1.4 1.2 -2.3 0.4
Comparative body size at age 10 0.4 1.2 1.5 -0.8 1.1 1.1 1.2 1.0 -1.1
Number of full brothers 0.5 0.6 1.8 0.1 0.9 1.4 -0.2 0.9 0.4
Worry too long after embarrassment 1.3 2.3 5.7 2.3 0.5 -0.3 2.4 -0.4 1.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 1.9 0.2 -1.4 -0.3 -0.4 -1.3 -0.3
Wheeze or whistling in the chest in last year 0.5 0.9 2.3 -0.9 0.9 1.0 -1.5 -0.9 -0.1
Number of children fathered 0.5 0.5 1.6 -0.8 1.3 0.7 -0.3 0.4 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 2.3 -0.1 0.1 0.4 1.5 1.5 -0.2
Age at first live birth 0.2 0.4 1.2 -0.6 -1.1 -0.1 0.1 -0.4 -0.8
Pulse wave peak to peak time 0.3 0.3 1.0 0.6 -0.6 0.0 0.2 -0.5 -1.0
Health satisfaction 0.5 0.6 1.4 0.9 -1.2 -0.1 1.0 -0.3 0.5
Shortness of breath walking on level ground 0.1 0.1 0.2 -0.2 -0.5 -0.4 0.2 -0.2 -0.1
Qualifications: College or University degree 0.7 2.2 7.1 -0.4 0.8 1.5 -0.5 1.6 -2.7
Eye problems/disorders: None of the above 2.0 2.4 6.5 0.9 1.3 1.7 -0.1 2.5 1.4
Mouth/teeth dental problems: Loose teeth 0.9 1.1 3.8 0.4 -0.6 -1.9 -0.3 -1.2 -0.6
Emphysema/chronic bronchitis 0.9 1.0 1.8 1.2 -1.3 -1.3 -0.8 -0.9 -0.1
Medication for pain relief, constipation, heartburn 0.4 0.6 3.0 0.4 0.7 0.2 -1.7 0.3 0.4
Neck or shoulder pain in last month 1.3 1.9 3.5 1.9 -1.4 -1.7 -0.1 -0.9 1.5
Medication: Blood pressure 0.8 1.4 3.5 0.4 -1.5 -1.9 0.8 -1.3 0.2
Angina (self-reported) 2.1 2.8 7.2 2.7 1.1 -1.1 -0.2 -2.2 1.4
Migraine (self-reported) 0.2 0.3 1.3 0.1 -0.1 -0.5 -0.5 -1.2 -0.1
Medication: Ibuprofen 0.6 0.7 1.7 -0.5 0.4 1.3 0.9 1.1 -0.3
Medication: Allopurinol 0.7 0.9 1.9 -0.7 -0.5 -1.3 0.7 -1.4 -0.6
Medication: Omeprazole 0.9 1.1 4.3 0.0 -1.2 -0.8 2.1 -0.4 0.1
Medication: Seretide 50 evohaler 0.8 0.9 2.9 0.1 -0.4 -1.2 -1.7 -0.9 0.0
Mean time to correctly identify matches 0.4 0.7 1.6 -0.8 -0.7 -1.3 -0.2 -0.8 -0.8
Heart disease (mother) 0.8 1.0 3.0 -0.9 1.7 1.4 -0.2 0.4 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.2 0.5 -0.2 -0.5 1.1 -1.0 -0.2
Whole body fat mass 0.0 0.1 0.2 0.1 0.3 0.1 -0.4 -0.2 -0.3
Leg fat mass (right) 0.1 0.5 1.3 -0.2 1.1 0.7 -0.9 0.5 -0.0
Arm predicted mass (right) 0.1 0.4 1.2 -0.0 0.1 -1.1 -0.9 -0.7 0.0
Pulse rate, automated reading 0.2 0.6 1.3 -0.3 -0.9 -0.4 0.9 -1.2 0.7
Alcohol intake frequency. 0.7 1.6 3.4 -1.6 1.8 1.0 -1.5 0.7 -0.3
Comparative height size at age 10 0.2 0.8 1.7 0.0 1.2 0.9 0.5 1.3 -0.8
Number of full sisters 0.5 0.6 1.1 0.4 0.6 0.7 -1.0 0.9 1.0
Suffer from ‘nerves’ 0.1 0.1 0.4 -0.3 -0.1 -0.4 -0.1 -0.2 0.7
Overall health rating 0.7 1.4 3.7 1.9 0.2 -0.0 0.9 -0.9 1.7
Chest pain or discomfort 1.1 1.6 4.8 2.2 1.2 1.0 -0.1 0.2 1.4
Had major operations 2.4 2.8 8.9 1.2 -0.1 -2.2 0.2 -3.0 1.2
Age at last live birth 0.2 0.3 0.8 -0.9 -0.4 0.3 0.7 -0.1 -0.4
Family relationship satisfaction 1.0 1.2 2.5 -1.4 0.1 0.8 -0.8 1.6 -1.1
Leg pain on walking 0.5 0.6 2.4 1.5 -0.2 -0.9 0.6 -0.2 0.4
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 1.3 0.6 0.3 -0.1 -0.7 0.0 1.2
Commuting to job workplace: Car/motor vehicle 1.3 1.5 3.7 0.8 1.2 1.9 -0.1 1.5 0.8
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.2 -0.3 -1.0 -1.1 -0.8 0.2 0.4
Medication: Aspirin 0.8 1.1 2.5 1.2 -0.6 -0.6 1.6 -0.7 1.1
Supplements: Vitamin C 0.3 0.4 1.6 -0.5 0.4 0.3 0.3 1.2 0.5
Knee pain experienced in last month 0.6 1.0 3.2 -0.7 1.8 1.1 -0.8 0.3 -0.0
Hypertension (Self-reported) 0.6 1.7 3.8 0.7 -1.2 -1.9 0.8 -1.4 1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.5 0.7 0.3 -0.2 -0.2 -0.3 0.0
Illnesses of father: Heart disease 1.2 1.7 4.9 1.0 0.6 -1.2 0.9 -1.4 2.2
Illnesses of siblings: Diabetes 1.0 1.2 2.0 1.1 1.4 0.8 -1.1 0.5 1.4
Smoking status: Previous 1.1 1.6 3.6 1.9 1.3 -0.0 1.4 0.7 1.4
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.3 4.7 -1.5 0.0 0.3 -0.8 -0.2 -2.2
Whole body fat-free mass 0.1 0.5 1.5 0.1 0.9 -0.5 -1.2 -0.2 -0.5
Leg fat-free mass (right) 0.1 0.7 1.4 -0.5 1.2 0.3 -0.9 0.2 -1.2
Arm fat percentage (left) 0.1 0.5 1.2 0.4 1.0 1.1 0.1 0.7 -0.2
Average weekly red wine intake 1.2 1.8 4.9 1.4 2.2 1.2 -0.2 1.0 1.1
Handedness (chirality/laterality): Left-handed 1.0 1.2 4.5 -2.1 -0.8 0.8 -0.1 0.4 -1.1
Mood swings 0.2 0.4 1.5 0.6 -0.2 -0.5 1.2 -0.2 0.2
Loneliness, isolation 0.2 0.3 0.6 -0.8 0.3 0.7 0.6 0.5 0.4
Long-standing illness, disability or infirmity 1.2 1.8 4.1 2.0 1.5 0.5 -0.6 -1.0 1.6
Ever had bowel cancer screening 2.0 2.3 4.3 0.4 -2.1 -2.1 0.9 -1.7 1.2
Diabetes diagnosed by doctor 1.0 1.7 3.5 0.2 -1.2 -1.9 1.3 -1.8 0.4
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.3 5.0 -2.2 -0.0 0.0 -0.2 0.8 -1.6
Friendships satisfaction 0.4 0.5 1.3 -1.1 -0.1 0.8 -0.6 0.8 -0.2
Qualifications: nursing, teaching 2.2 3.4 4.8 -2.0 1.8 1.7 -1.8 2.2 -1.5
Commuting to job workplace: Walk 1.9 2.0 3.8 1.9 0.1 -1.5 -1.8 -1.4 0.9
Eye problems/disorders: Cataract 1.1 1.3 4.1 -0.7 -0.8 -1.2 0.0 -2.0 -1.1
Mouth/teeth dental problems: Mouth ulcers 0.9 1.5 4.6 2.1 1.1 -0.9 0.6 -1.2 0.2
Medication for cholesterol 0.7 1.1 5.0 -0.7 -0.4 -0.8 -0.7 -0.2 -2.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.9 1.9 1.0 0.5 -0.7 1.4 -0.3 1.1
Back pain experienced in last month 0.3 0.5 2.2 -0.1 -1.5 0.1 0.4 -0.5 -0.6
Mineral and other dietary supplements 0.5 0.7 2.2 -0.3 -1.5 -0.3 -0.8 -1.0 -0.5
Breast cancer (self-reported) 1.0 1.2 2.5 1.6 1.0 1.0 -0.7 0.5 1.4
Asthma (self-reported) 0.5 1.0 1.7 -1.3 1.2 1.2 -1.1 -0.6 -0.2
Osteoporosis (self-reported) 0.6 0.8 2.1 1.3 1.4 -0.1 -0.2 0.0 1.0
Osteoarthritis (self-reported) 0.2 0.3 0.8 0.0 0.5 0.6 -0.9 -0.0 0.4
Medication: Aspirin 1.4 1.8 4.6 1.7 -0.7 -0.9 2.1 -0.9 1.2
Medication: Gliclazide 1.9 2.2 4.5 0.0 -2.1 -1.7 1.3 -2.0 0.1
Illnesses of father: None of the above (group 1) 0.3 0.4 1.7 -0.2 0.4 0.5 -1.3 -0.3 0.5
Smoking status: Current 0.3 0.5 1.0 -0.2 -0.8 -1.0 0.8 -0.9 0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.1 0.5 0.2 -0.2 -0.7 0.3 -0.3 -0.1
Whole body water mass 0.1 0.5 1.5 0.0 0.8 -0.6 -1.2 -0.3 -0.5
Leg predicted mass (right) 0.1 0.7 1.4 -0.5 1.2 0.3 -1.0 0.2 -1.1
Arm fat mass (left) 0.1 0.3 1.0 0.3 1.0 0.4 -0.5 0.4 -0.2
Number of self-reported non-cancer illnesses 0.1 0.2 0.9 0.4 0.1 0.1 0.6 -1.0 0.0
Average weekly champagne plus white wine intake 0.7 1.0 4.4 0.1 -2.1 -0.7 0.7 -0.8 -0.3
Miserableness 0.8 1.3 2.9 1.5 -0.9 -1.7 0.5 -1.0 0.9
Guilty feelings 1.5 2.3 5.1 2.3 -0.8 -1.3 1.2 -1.6 1.6
Wears glasses or contact lenses 0.7 0.8 3.5 -0.4 -0.7 -0.5 1.9 -0.6 0.4
Ever taken oral contraceptive pill 1.3 1.4 5.3 0.3 -0.4 -1.3 2.3 -1.0 0.7
Hearing aid user 0.9 1.0 2.4 -0.5 1.6 1.3 -0.1 1.4 0.1
Mother’s age at death 0.3 0.4 0.7 0.3 -0.6 -0.2 -0.6 0.8 -0.8
Financial situation satisfaction 0.3 0.4 1.1 -0.7 0.0 0.3 -1.0 0.6 -0.4
Tinnitus: Yes, now most or all of the time 1.6 1.9 4.5 -1.0 -1.6 -1.4 0.5 -1.1 -2.1
Commuting to job workplace: Public transport 0.4 0.5 1.3 -1.2 -0.4 -0.0 -0.3 -0.9 -0.6
Eye problems/disorders: Glaucoma 0.3 0.4 1.5 0.4 -0.5 -1.2 0.3 -0.6 0.1
Medication: Blood pressure 0.2 0.5 1.9 0.6 0.4 0.2 -0.5 -0.2 1.4
Pain type(s) experienced in last month: Hip pain 0.3 0.3 1.8 1.3 -0.2 0.1 -0.3 0.2 0.2
Supplements: Fish oil (including cod liver oil) 0.4 0.5 2.1 -0.3 1.4 0.3 0.7 0.3 0.0
High cholesterol (Self-reported) 0.2 0.3 0.6 -0.4 0.5 0.1 -0.8 -0.8 0.5
Medication: Bendroflumethiazide 1.6 2.4 6.5 2.2 -0.1 -0.9 1.3 -0.6 2.5
Medication: Paracetamol 0.7 1.0 3.7 -1.9 0.1 0.4 1.0 0.1 -1.1
Medication: Lisinopril 0.8 1.0 3.4 -1.8 0.0 0.7 0.4 -0.5 -1.3
Medication: Atorvastatin 0.8 1.0 2.1 1.1 1.5 0.1 0.8 -0.4 1.3
Illnesses of father: High blood pressure 0.8 1.0 2.6 -0.6 -0.3 -1.6 1.2 -1.1 -0.3
Alcohol drinker status: Never 1.0 1.2 2.7 -1.4 -0.6 -1.2 -0.8 -1.6 -0.4
Ever smoked 0.7 1.3 3.8 1.9 1.0 -0.4 0.8 -0.3 1.4
Basal metabolic rate 0.1 0.4 1.2 0.1 0.9 -0.4 -1.1 -0.2 -0.5
Leg fat percentage (left) 0.1 0.2 0.4 -0.2 0.6 0.2 -0.6 0.4 0.5
Arm fat-free mass (left) 0.1 0.7 1.9 -0.2 0.1 -1.2 -1.4 -0.7 -0.1
Number of operations (self-reported) 1.2 1.8 4.8 0.7 -0.1 -1.7 0.5 -2.2 1.4
Average weekly beer plus cider intake 0.4 0.6 1.7 -0.5 -1.3 -0.7 0.7 -0.6 0.3
Irritability 1.3 2.2 5.7 1.2 -0.9 -2.4 0.5 -1.8 1.2
Risk taking 1.8 2.6 5.2 -1.2 1.0 1.4 -2.3 1.7 -1.7
Ever had prostate specific antigen (PSA) test 0.4 0.4 1.0 -0.5 0.6 0.7 0.8 0.2 -1.0
Fractured/broken bones in last 5 years 0.5 0.7 1.3 0.3 0.9 0.6 -0.8 0.9 -1.2
Age started oral contraceptive pill 0.1 0.1 0.5 -0.4 -0.7 -0.1 -0.1 -0.2 0.4
Diastolic blood pressure, automated reading 0.5 1.6 6.2 0.9 -0.8 -0.0 0.9 -1.0 2.5
Ever depressed for a whole week 0.3 0.4 1.0 0.7 -1.0 -0.8 0.5 -0.1 -0.2
Unable to work because of sickness or disability 0.3 0.4 2.1 -0.0 0.3 -0.3 -1.5 -0.2 -0.5
Commuting to job workplace: Cycle 1.2 1.4 3.1 1.8 1.4 0.8 -1.5 -0.1 0.8
Myopia 1.0 1.5 3.6 0.7 -1.4 -1.9 0.8 -1.1 1.0
Vascular/heart problems diagnosed by doctor 0.6 1.8 3.6 -0.6 1.2 1.9 -0.5 1.8 -1.3
Cholesterol lowering medication 0.5 0.7 2.1 -0.3 -0.1 0.4 0.7 -1.1 1.5
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 5.7 -0.4 -0.8 -0.5 2.4 0.0 -0.3
Pain experienced in last month 0.1 0.2 0.5 0.6 -0.2 -0.6 0.7 0.2 -0.5
Supplements: Calcium 1.3 1.4 3.4 1.7 1.9 0.4 -0.8 0.7 1.0
Basal cell carcinoma (self-reported) 2.2 2.6 6.4 1.1 -1.9 -2.5 -0.6 -2.0 -0.6
Heart attack/myocardial infarction (self-reported) 0.9 1.1 4.4 0.9 2.1 0.8 0.3 0.2 0.8
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 2.4 -0.6 1.5 0.7 -0.9 -0.7 0.0
Heart disease (siblings) 0.5 0.6 2.8 0.6 -0.0 0.4 -0.4 0.2 1.7
Alcohol drinker status: Previous 0.5 0.6 1.5 -1.2 0.3 -0.9 -0.5 -1.0 -0.1
Pack years of smoking 0.2 0.2 0.6 0.1 0.4 0.2 -0.8 -0.4 0.6
Impedance of whole body 0.2 0.9 4.0 0.6 -2.0 -0.4 0.3 -0.7 -0.2
Leg fat mass (left) 0.1 0.3 0.9 -0.1 1.0 0.4 -0.8 0.5 0.0
Arm predicted mass (left) 0.1 0.7 2.0 0.0 -0.2 -1.4 -1.2 -0.9 -0.0