Hub : Traits :

Heel bone mineral density (BMD) T-score, automated (left)

787 significantly associated models · 259 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 752566 1567206 1 1 1.6e-08 1.6e-07 1.0e+00 100 KLHL17
2 1 7715776 9571422 2 1 1.7e-11 1.3e-09 2.7e-01 97 RERE
3 1 15123100 16552772 1 1 1.0e-08 1.4e-08 2.3e-01 96 CASP9
4 1 37730550 39167106 2 1 1.1e-08 3.0e-08 5.4e-01 99 FHL3
5 1 112312154 114196883 4 1 1.4e-14 1.4e-14 1.0e-02 89 WNT2B
6 1 118878656 120380990 1 1 2.2e-09 2.7e-10 1.1e-03 73 WARS2
7 1 219166366 220808921 1 1 1.3e-09 1.4e-10 3.5e-02 89 SLC30A10
8 1 239954252 241470634 1 1 5.5e-37 5.2e-50 2.2e-16 70 GREM2
9 2 39636469 41534961 1 1 6.9e-09 1.3e-12 4.5e-08 40 SLC8A1
10 2 41579722 42984340 1 1 1.3e-08 1.6e-19 1.5e-12 39 PKDCC
11 2 53507604 55895321 7 3 1.4e-36 7.6e-55 6.0e-40 28 AC093110.3 SPTBN1 TSPYL6
12 2 64168232 65573478 1 1 4.9e-09 1.4e-08 9.5e-02 91 SERTAD2
13 2 118148428 119568213 1 2 9.7e-08 6.8e-36 1.6e-29 19 INSIG2
14 2 181042370 182430120 1 1 2.1e-07 1.7e-06 4.0e-01 97 FTH1P20
15 2 202200575 203592180 1 1 3.1e-11 1.8e-32 4.0e-29 11 FZD7
16 3 48515079 50800146 14 1 1.0e-11 8.3e-12 2.9e-02 90 AMT
17 3 55894951 57350441 1 1 3.0e-07 2.1e-09 7.9e-04 69 CCDC66
18 3 100350244 101922655 1 1 1.7e-07 2.4e-07 8.9e-03 74 SENP7
19 3 155695485 157456920 4 2 2.1e-15 2.6e-15 1.0e+00 100 LEKR1 TIPARP
20 4 69713 2058475 13 9 1.8e-39 8.5e-31 NaN NaN CRIPAK CTBP1-AS2 FGFRL1 UVSSA
21 4 85698680 89692911 6 4 4.1e-14 8.8e-14 1.0e+00 100 HSD17B13 IBSP RP13-514E23.2 SPP1
22 4 144882744 147552337 3 2 3.0e-10 4.5e-11 1.8e-05 57 MMAA ZNF827
23 5 41726855 43401980 1 1 2.5e-07 4.8e-07 4.8e-02 84 GHR
24 5 53906103 55410585 1 1 7.8e-08 1.2e-07 4.5e-01 98 SKIV2L2
25 5 123274918 124774701 1 1 3.1e-07 1.7e-06 5.0e-03 66 ZNF608
26 6 44079216 46043561 1 2 2.3e-16 8.1e-26 5.6e-13 53 SUPT3H
27 6 73710903 75236060 1 1 1.7e-09 2.6e-11 4.2e-03 82 CD109
28 6 83204071 84606555 1 1 3.6e-07 2.5e-08 2.0e-03 69 RWDD2A
29 6 126752798 128536730 4 4 6.6e-80 1.5e-89 5.1e-05 96 ECHDC1 RSPO3
30 6 132368241 134546685 2 2 2.5e-10 2.1e-36 2.3e-25 32 EYA4 VNN2
31 6 151030107 153120904 4 5 1.1e-22 4.7e-76 9.9e-60 22 C6orf97 CCDC170 ESR1 RMND1
32 7 14953576 16424863 1 1 3.3e-09 5.4e-14 2.6e-08 45 MEOX2
33 7 26871554 28479059 2 1 8.0e-09 1.5e-14 6.1e-11 28 AC004549.6
34 7 37250727 38764855 2 3 2.9e-22 5.0e-41 3.9e-24 43 EPDR1
35 7 91380845 93160671 2 1 2.9e-09 3.6e-08 1.1e-02 78 GATAD1
36 7 119892061 121729795 5 8 1.8e-238 0.0e+00 NaN NaN C7orf58 CPED1 FAM3C
37 8 8092025 13120332 39 11 2.0e-22 5.7e-26 NaN NaN AF131215.2 ERI1 FAM86B3P MSRA MTMR9 NEIL2 PPP1R3B
38 8 70788124 72811579 6 1 1.1e-09 4.8e-10 1.8e-08 18 XKR9
39 9 96102832 97759920 2 2 1.1e-08 6.0e-08 6.9e-03 75 PTPDC1 ZNF169
40 9 136510762 138027657 1 1 4.1e-07 3.5e-07 1.0e+00 100 RXRA
41 10 122989048 124407934 1 1 4.1e-08 6.7e-07 4.8e-02 84 RP11-500G22.2
42 11 26693196 28220506 2 2 4.8e-15 4.0e-26 8.2e-09 70 LGR4 LIN7C
43 11 34460769 35949179 1 1 5.6e-09 4.3e-09 1.0e+00 100 CD44
44 11 45929961 48285906 14 1 2.3e-16 5.4e-17 1.0e+00 100 ZNF408
45 11 59239839 62326265 6 3 1.9e-08 2.5e-09 1.2e-02 82 FADS2 MS4A6A MS4A7
46 11 64615450 66116911 4 2 7.4e-10 2.5e-08 1.2e-03 66 LTBP3 SIPA1
47 11 67339278 69623641 8 3 4.1e-16 4.5e-23 1.7e-03 90 IGHMBP2 PPP6R3 TPCN2
48 11 74119638 75612878 1 1 7.0e-08 7.2e-05 6.2e-02 78 SLCO2B1
49 11 111325300 112921923 3 2 6.5e-31 3.8e-45 1.8e-13 73 BCO2 RP11-356J5.12
50 11 114340771 116072203 1 2 1.4e-12 1.4e-16 6.2e-01 100 CADM1
51 11 118466249 119878269 1 1 2.6e-08 1.5e-07 3.2e-06 22 CBL
52 12 52990150 54388473 1 1 1.7e-07 2.5e-08 1.0e+00 100 PFDN5
53 12 89406493 90799212 1 1 5.7e-13 2.0e-29 3.3e-20 33 LOC338758
54 12 123558705 125196704 5 1 1.9e-10 3.4e-08 7.0e-02 89 DNAH10
55 13 42149812 43594717 1 1 2.7e-07 6.3e-27 3.5e-21 23 AKAP11
56 13 49557805 51390447 2 2 2.4e-10 2.3e-09 1.0e+00 100 DLEU2 EBPL
57 13 98746497 100437143 2 2 3.4e-16 2.9e-18 2.5e-02 93 DOCK9
58 14 34754717 36195312 1 1 1.1e-07 1.1e-07 1.0e+00 100 SRP54
59 14 53731553 55118795 1 1 1.7e-32 1.7e-33 5.8e-07 83 BMP4
60 14 60207565 61649612 1 1 2.8e-07 9.6e-08 1.1e-02 77 C14orf39
61 14 103161201 105211221 9 1 1.5e-18 1.1e-18 1.0e+00 100 MARK3
62 15 50509591 51995763 1 1 3.8e-09 6.0e-15 1.1e-09 39 AP4E1
63 15 90208219 91886448 3 1 1.1e-09 1.1e-09 1.0e+00 100 ZNF774
64 16 86671 1115377 2 1 2.5e-08 3.5e-11 2.9e-04 70 MRPL28
65 16 66062381 68536105 7 2 3.9e-11 1.8e-13 3.4e-03 84 CTCF NAE1
66 17 1263564 2899908 1 1 3.0e-08 3.0e-25 1.6e-18 28 SMG6
67 17 7084911 8484683 2 1 1.3e-08 3.0e-07 5.5e-01 99 LSMD1
68 17 27244473 28642380 1 1 2.6e-08 5.6e-09 1.0e+00 100 CORO6
69 17 39559539 40930095 1 1 1.4e-07 1.9e-05 1.0e-03 41 DHX58
70 17 41393295 43332365 9 1 5.9e-17 2.4e-17 1.0e+00 100 HDAC5
71 18 12966058 14385836 1 1 6.8e-08 2.3e-25 4.2e-19 26 FAM210A
72 19 32372820 34457352 10 8 1.2e-35 2.7e-45 NaN NaN C19orf40 CTD-2540B15.12 GPATCH1 RHPN2
73 20 32819871 34556216 5 1 3.1e-10 1.2e-09 1.0e+00 100 MYH7B
74 22 19003938 20330744 1 1 7.8e-10 1.6e-42 1.6e-34 20 SEPT5
75 22 28792887 30261219 1 1 4.8e-23 3.8e-23 1.0e+00 100 KREMEN1
76 22 40789606 42301748 2 1 4.7e-10 2.6e-10 1.0e+00 100 L3MBTL2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (including proxy) 1.16 1 1 3.0 0.00 1.0e+00 MS4A6A
Crohns Disease (2017) 1.24 3 2 6.1 0.00 1.0e+00 AMT MARK3 RSPO3
Irritable Bowel Disease (IBD) 1.02 3 1 3.0 0.00 1.0e+00 AMT MARK3 WNT2B
Reaction Time 0.92 2 0 0.0 0.00 1.0e+00 DNAH10 ZNF408
Verbal and Numeric Reasoning (VNR) 0.89 2 0 0.0 0.00 1.0e+00 AMT XKR9
Breast Cancer 1.05 1 1 3.0 0.00 1.0e+00 RMND1
Ovarian Cancer 0.97 1 1 3.0 0.00 1.0e+00 LEKR1
Coronary Artery Disease (CAD) 1.10 1 0 0.0 0.00 1.0e+00 DNAH10
Crohns Disease (2012) 1.10 2 1 3.0 0.00 1.0e+00 AMT RSPO3
HDL Cholesterol 1.44 5 2 6.1 -0.13 8.4e-01 CTD-2540B15.12 DNAH10 FADS2 RSPO3 ZNF408
LDL Cholesterol 1.12 1 1 3.0 0.00 1.0e+00 FADS2
Lupus 1.61 4 1 3.0 -0.95 1.2e-02 AF131215.2 CD44 ERI1 MTMR9
Neuroticism 2.70 4 4 12.1 1.00 8.0e-08 AF131215.2 ERI1 MTMR9 NEIL2
Rheumatoid Arthritis 1.40 1 0 0.0 0.00 1.0e+00 FADS2
Schizophrenia 1.24 1 1 3.0 0.00 1.0e+00 RERE
Triglycerides 2.01 6 2 6.1 0.18 6.6e-01 DNAH10 FADS2 HSD17B13 NEIL2 RSPO3 ZNF408
Blood Eosinophil Count 0.85 15 8 24.2 -0.01 9.7e-01 AKAP11 AMT CTCF DLEU2 EBPL FADS2 GATAD1 L3MBTL2 LGR4 MARK3 PPP6R3 RERE SENP7 SIPA1 ZNF169
Blood Platelet Count 1.37 19 13 39.4 -0.22 3.7e-01 CBL CCDC66 CTD-2540B15.12 DOCK9 FADS2 GATAD1 HDAC5 HSD17B13 LTBP3 MARK3 MS4A7 RP13-514E23.2 RSPO3 SENP7 SEPT5 SERTAD2 SMG6 TIPARP WNT2B
Blood Red Count 1.05 24 13 39.4 0.16 4.4e-01 AC093110.3 AMT CCDC170 CCDC66 CORO6 CTD-2540B15.12 DNAH10 DOCK9 FADS2 FTH1P20 FZD7 GATAD1 HDAC5 LSMD1 MARK3 PFDN5 PPP6R3 RHPN2 RSPO3 RXRA SERTAD2 SLCO2B1 SPTBN1 TIPARP
Blood White Count 0.91 13 8 24.2 0.14 6.5e-01 CORO6 DNAH10 FADS2 FHL3 FTH1P20 LSMD1 MS4A6A RERE RP13-514E23.2 SPTBN1 SUPT3H TIPARP ZNF169
Heel T-Score 38.86 103 102 309.1 -0.99 1.8e-109 AC004549.6 AC093110.3 AKAP11 AMT AP4E1 BCO2 BMP4 C14orf39 C19orf40 C6orf97 C7orf58 CADM1 CASP9 CBL CCDC170 CCDC66 CD109 CD44 CORO6 CPED1 CRIPAK CTBP1-AS2 CTCF CTD-2540B15.12 DHX58 DLEU2 DNAH10 DOCK9 EBPL ECHDC1 EPDR1 ESR1 EYA4 FADS2 FAM210A FAM3C FGFRL1 FHL3 FTH1P20 FZD7 GATAD1 GHR GPATCH1 GREM2 HDAC5 HSD17B13 IBSP IGHMBP2 INSIG2 KLHL17 KREMEN1 L3MBTL2 LEKR1 LGR4 LIN7C LOC338758 LSMD1 LTBP3 MARK3 MEOX2 MMAA MRPL28 MS4A6A MS4A7 MYH7B NAE1 PFDN5 PKDCC PPP6R3 PTPDC1 RERE RHPN2 RMND1 RP11-356J5.12 RP11-500G22.2 RP13-514E23.2 RSPO3 RWDD2A SENP7 SEPT5 SERTAD2 SIPA1 SKIV2L2 SLC30A10 SLC8A1 SLCO2B1 SMG6 SPP1 SPTBN1 SRP54 SUPT3H TIPARP TPCN2 TSPYL6 UVSSA VNN2 WARS2 WNT2B XKR9 ZNF169 ZNF408 ZNF774 ZNF827
BMI 0.89 11 7 21.2 -0.13 7.0e-01 AMT CADM1 CBL CORO6 DNAH10 IGHMBP2 LOC338758 MARK3 PPP6R3 WARS2 ZNF608
Height 1.83 46 35 106.1 -0.13 3.5e-01 AP4E1 C14orf39 C7orf58 CADM1 CCDC66 CORO6 CPED1 CRIPAK CTBP1-AS2 CTCF CTD-2540B15.12 DLEU2 DNAH10 DOCK9 EBPL EPDR1 FADS2 FGFRL1 FHL3 GATAD1 GHR GPATCH1 HSD17B13 IBSP KREMEN1 LEKR1 MARK3 MRPL28 MYH7B PPP6R3 RHPN2 RP11-500G22.2 RP13-514E23.2 RSPO3 SLC8A1 SLCO2B1 SPP1 SUPT3H TPCN2 UVSSA WARS2 WNT2B ZNF169 ZNF408 ZNF774 ZNF827
Waist Hip Ratio (WHR) 3.54 21 17 51.5 -0.12 5.7e-01 AMT C14orf39 C7orf58 CPED1 CRIPAK CTD-2540B15.12 DLEU2 DNAH10 ECHDC1 FAM3C FGFRL1 HDAC5 MYH7B PPP6R3 RSPO3 SIPA1 SLC30A10 TIPARP UVSSA WARS2 XKR9
Systolic Blood Pressure 1.71 18 12 36.4 -0.18 4.7e-01 AP4E1 BMP4 CASP9 CRIPAK ESR1 FHL3 FTH1P20 GATAD1 LSMD1 NAE1 NEIL2 RERE RP13-514E23.2 SIPA1 SMG6 WNT2B ZNF408 ZNF827
Smoking Status 0.91 4 2 6.1 -0.59 4.1e-01 FTH1P20 MARK3 RERE SMG6
Allergy or Eczema 1.09 3 2 6.1 0.00 1.0e+00 L3MBTL2 RERE ZNF774
Cardiovascular Disease 1.14 8 2 6.1 -0.01 9.8e-01 CORO6 FTH1P20 GATAD1 KREMEN1 LSMD1 MARK3 RP13-514E23.2 SIPA1
Hypothyroidism (self reported) 1.15 4 2 6.1 0.69 3.1e-01 AKAP11 FADS2 FHL3 FTH1P20
Respiratory disease 1.31 4 2 6.1 0.26 7.4e-01 FADS2 LTBP3 RERE ZNF169
Type 2 Diabetes (T2D) 1.05 2 0 0.0 0.00 1.0e+00 LEKR1 MARK3
Lung FEV1/FVC ratio 1.34 8 6 18.2 0.09 8.2e-01 BMP4 CORO6 FAM3C L3MBTL2 LTBP3 PPP1R3B RERE SERTAD2
Lung FVC 0.98 9 4 12.1 -0.45 1.9e-01 BMP4 CD109 DNAH10 EBPL IGHMBP2 MYH7B RSPO3 WNT2B ZNF827
Neuroticism 0.81 2 1 3.0 0.00 1.0e+00 RERE ZNF408
Chronotype (morning person) 1.28 4 2 6.1 0.38 5.2e-01 C14orf39 CRIPAK RP11-500G22.2 UVSSA
Hair Pigment 0.59 13 7 21.2 -0.35 2.4e-01 CD44 CORO6 FADS2 IGHMBP2 MARK3 MYH7B PPP1R3B PPP6R3 SIPA1 SUPT3H TPCN2 ZNF408 ZNF774
Tanning 0.39 4 4 12.1 0.21 7.9e-01 IGHMBP2 LEKR1 MYH7B TPCN2
Hand grip strength (left) 1.46 3 1 3.0 -0.78 6.6e-02 C7orf58 CRIPAK DNAH10
Number of treatments/medications taken 1.01 1 0 0.0 0.00 1.0e+00 FADS2
Sensitivity / hurt feelings 1.56 4 3 9.1 -1.00 4.0e-04 AF131215.2 ERI1 FAM86B3P MTMR9
Frequency of depressed mood in last 2 weeks 1.60 2 0 0.0 0.00 1.0e+00 ERI1 ZNF408
Relative age of first facial hair 0.89 1 0 0.0 0.00 1.0e+00 SIPA1
Ever had hysterectomy (womb removed) 1.55 1 0 0.0 0.00 1.0e+00 CD109
Systolic blood pressure, automated reading 2.49 14 9 27.3 0.56 1.9e-02 AF131215.2 AP4E1 ERI1 ESR1 FHL3 GATAD1 MTMR9 NEIL2 PPP1R3B RERE RP13-514E23.2 SMG6 WNT2B ZNF827
Impedance of leg (right) 1.96 18 11 33.3 -0.69 3.8e-04 AF131215.2 C14orf39 CADM1 CRIPAK DHX58 ERI1 FAM86B3P GHR IBSP IGHMBP2 L3MBTL2 MARK3 MTMR9 NEIL2 PPP1R3B PPP6R3 WARS2 WNT2B
Leg fat-free mass (left) 1.97 26 13 39.4 0.43 1.0e-02 AF131215.2 AP4E1 C14orf39 CRIPAK DLEU2 DOCK9 EBPL ERI1 FAM86B3P FGFRL1 FHL3 GATAD1 GHR IBSP IGHMBP2 LOC338758 MTMR9 MYH7B NEIL2 PPP6R3 RP13-514E23.2 SLCO2B1 SUPT3H UVSSA ZNF408 ZNF608
Trunk fat percentage 1.18 11 4 12.1 -0.04 9.0e-01 AMT CORO6 CPED1 CTD-2540B15.12 DNAH10 HDAC5 RERE RXRA SPTBN1 WNT2B ZNF608
Hand grip strength (right) 1.53 5 3 9.1 -0.71 3.3e-02 C14orf39 C7orf58 CRIPAK DNAH10 UVSSA
Current tobacco smoking 1.36 2 0 0.0 0.00 1.0e+00 FAM86B3P MTMR9
Maternal smoking around birth 1.04 1 0 0.0 0.00 1.0e+00 MARK3
Fed-up feelings 1.64 6 4 12.1 -1.00 9.6e-09 AF131215.2 ERI1 FAM86B3P MTMR9 NEIL2 ZNF408
Relative age voice broke 0.84 1 0 0.0 0.00 1.0e+00 AMT
Age when periods started (menarche) 1.45 3 2 6.1 0.00 1.0e+00 C14orf39 RP11-500G22.2 TIPARP
High blood pressure 1.99 10 6 18.2 0.46 9.5e-02 AF131215.2 ERI1 FTH1P20 KREMEN1 LSMD1 MTMR9 NEIL2 RP13-514E23.2 SIPA1 ZNF408
Hayfever, allergic rhinitis or eczema 1.10 2 2 6.1 0.00 1.0e+00 RERE ZNF774
Medication: Levothyroxine sodium 1.41 5 1 3.0 -0.98 5.1e-04 AF131215.2 AKAP11 ERI1 FADS2 MTMR9
Sitting height 1.94 25 17 51.5 0.32 9.7e-02 AP4E1 C14orf39 CD109 CRIPAK CTCF DLEU2 DOCK9 EBPL EPDR1 ERI1 FHL3 GATAD1 HSD17B13 IBSP KREMEN1 MYH7B PPP1R3B PPP6R3 RSPO3 RXRA SLCO2B1 SUPT3H TIPARP ZNF169 ZNF408
High blood pressure (mother) 1.32 1 0 0.0 0.00 1.0e+00 PFDN5
Body mass index (BMI) 1.51 13 8 24.2 0.78 2.5e-04 AF131215.2 AMT CADM1 CORO6 DNAH10 ERI1 FAM86B3P IGHMBP2 MARK3 MTMR9 NEIL2 PPP1R3B ZNF608
Impedance of leg (left) 2.02 17 11 33.3 -0.65 1.5e-03 AF131215.2 CADM1 DHX58 ERI1 FAM86B3P GHR IBSP IGHMBP2 INSIG2 L3MBTL2 MARK3 MTMR9 NEIL2 PPP1R3B PPP6R3 WARS2 WNT2B
Leg predicted mass (left) 1.97 25 13 39.4 0.42 1.6e-02 AF131215.2 AP4E1 C14orf39 CRIPAK DLEU2 DOCK9 EBPL ERI1 FAM86B3P FHL3 GATAD1 GHR IBSP IGHMBP2 LOC338758 MTMR9 MYH7B NEIL2 PPP6R3 RP13-514E23.2 SLCO2B1 SUPT3H UVSSA ZNF408 ZNF608
Trunk fat mass 1.24 9 4 12.1 0.37 3.3e-01 AMT C14orf39 CTD-2540B15.12 DNAH10 FAM86B3P HDAC5 RERE WNT2B ZNF608
Waist circumference 1.19 7 2 6.1 0.50 2.6e-01 AMT CADM1 CRIPAK MARK3 RSPO3 TIPARP ZNF608
Past tobacco smoking 0.94 2 0 0.0 0.00 1.0e+00 FTH1P20 MYH7B
Nervous feelings 2.58 7 4 12.1 -0.99 6.7e-09 AF131215.2 ERI1 FAM86B3P MTMR9 NEIL2 PPP1R3B SMG6
Hearing difficulty/problems with background noise 1.32 1 0 0.0 0.00 1.0e+00 ZNF408
Forced vital capacity (FVC) 1.50 14 6 18.2 0.29 2.7e-01 CORO6 CRIPAK CTBP1-AS2 DLEU2 EBPL FGFRL1 FHL3 PPP6R3 PTPDC1 RSPO3 RXRA TPCN2 UVSSA ZNF169
Heel bone mineral density (BMD) T-score, automated (right) 29.67 111 93 281.8 1.00 4.0e-161 AC004549.6 AC093110.3 AF131215.2 AKAP11 AMT AP4E1 BCO2 BMP4 C14orf39 C19orf40 C6orf97 C7orf58 CADM1 CASP9 CBL CCDC170 CCDC66 CD109 CD44 CORO6 CPED1 CRIPAK CTBP1-AS2 CTCF CTD-2540B15.12 DHX58 DLEU2 DNAH10 DOCK9 EBPL ECHDC1 EPDR1 ERI1 ESR1 EYA4 FADS2 FAM210A FAM3C FAM86B3P FGFRL1 FHL3 FTH1P20 FZD7 GATAD1 GHR GPATCH1 GREM2 HDAC5 HSD17B13 IBSP IGHMBP2 INSIG2 KLHL17 KREMEN1 L3MBTL2 LEKR1 LGR4 LIN7C LOC338758 LSMD1 LTBP3 MARK3 MEOX2 MMAA MRPL28 MS4A6A MS4A7 MSRA MTMR9 MYH7B NAE1 NEIL2 PFDN5 PKDCC PPP1R3B PPP6R3 PTPDC1 RERE RHPN2 RMND1 RP11-356J5.12 RP11-500G22.2 RP13-514E23.2 RSPO3 RWDD2A RXRA SENP7 SEPT5 SERTAD2 SIPA1 SKIV2L2 SLC30A10 SLC8A1 SLCO2B1 SMG6 SPP1 SPTBN1 SRP54 SUPT3H TIPARP TPCN2 TSPYL6 UVSSA VNN2 WARS2 WNT2B XKR9 ZNF169 ZNF408 ZNF774 ZNF827
Allergy 1.18 4 1 3.0 0.39 6.1e-01 FADS2 L3MBTL2 RERE ZNF774
Fluid intelligence score 0.93 1 0 0.0 0.00 1.0e+00 AMT
Illnesses of siblings 1.22 1 0 0.0 0.00 1.0e+00 CORO6
Neuroticism score 2.49 7 5 15.2 -0.99 9.4e-09 AF131215.2 ERI1 FAM86B3P MTMR9 NEIL2 PPP1R3B ZNF408
Weight 1.62 22 6 18.2 0.53 2.8e-03 AF131215.2 AMT C14orf39 CADM1 CBL CRIPAK DLEU2 DOCK9 ERI1 FAM86B3P GATAD1 GHR IBSP IGHMBP2 MRPL28 MYH7B NEIL2 PPP1R3B PPP6R3 UVSSA WNT2B ZNF608
Impedance of arm (right) 2.23 28 17 51.5 -0.44 9.9e-03 AF131215.2 CADM1 CRIPAK CTBP1-AS2 CTD-2540B15.12 DHX58 DNAH10 ERI1 FAM86B3P FZD7 GHR IBSP IGHMBP2 KREMEN1 L3MBTL2 MARK3 MTMR9 MYH7B NEIL2 PPP1R3B PPP6R3 RXRA SMG6 SPTBN1 SRP54 TIPARP WARS2 WNT2B
Arm fat percentage (right) 1.23 9 5 15.2 0.75 1.2e-02 AF131215.2 AMT CADM1 CORO6 DNAH10 ERI1 FAM86B3P HDAC5 MARK3
Trunk fat-free mass 2.25 27 19 57.6 0.27 1.2e-01 AF131215.2 C14orf39 CCDC66 CRIPAK CTBP1-AS2 DLEU2 DNAH10 DOCK9 EBPL FAM86B3P FGFRL1 FHL3 GATAD1 GHR HSD17B13 IBSP IGHMBP2 MYH7B PPP6R3 RP13-514E23.2 RXRA SUPT3H UVSSA ZNF169 ZNF408 ZNF774 ZNF827
Hip circumference 1.41 16 4 12.1 0.19 4.5e-01 AF131215.2 AP4E1 C14orf39 CADM1 CBL DLEU2 DNAH10 ERI1 FAM86B3P GATAD1 MYH7B NEIL2 PPP1R3B RSPO3 WARS2 ZNF608
Father's age at death 1.17 1 0 0.0 0.00 1.0e+00 ERI1
Worrier / anxious feelings 2.72 6 5 15.2 -0.99 4.5e-08 AF131215.2 ERI1 FAM86B3P MTMR9 NEIL2 PPP1R3B
Frequency of tiredness / lethargy in last 2 weeks 1.28 2 0 0.0 0.00 1.0e+00 AMT ZNF408
Number of live births 0.97 1 1 3.0 0.00 1.0e+00 FADS2
Forced expiratory volume in 1-second (FEV1) 1.60 12 3 9.1 0.16 5.9e-01 CRIPAK CTBP1-AS2 DLEU2 EBPL ERI1 FHL3 PPP6R3 RSPO3 RXRA TPCN2 UVSSA ZNF169
Pulse rate 1.63 2 1 3.0 0.00 1.0e+00 AMT FADS2
Qualifications: A levels/AS levels or equivalent 0.93 2 0 0.0 0.00 1.0e+00 AMT FZD7
Mouth/teeth dental problems: Dentures 1.17 1 0 0.0 0.00 1.0e+00 ERI1
Asthma 1.31 3 2 6.1 0.00 1.0e+00 FADS2 LTBP3 RERE
Forced expiratory volume in 1-second (FEV1), Best measure 1.58 10 1 3.0 -0.08 7.9e-01 CRIPAK DLEU2 EBPL ERI1 FHL3 PPP6R3 PTPDC1 RXRA UVSSA ZNF169
Impedance of arm (left) 2.05 26 12 36.4 -0.40 2.7e-02 AF131215.2 CADM1 CRIPAK CTD-2540B15.12 DHX58 DNAH10 ERI1 FAM86B3P FZD7 GHR IBSP IGHMBP2 KREMEN1 L3MBTL2 MARK3 MTMR9 MYH7B NEIL2 PPP1R3B PPP6R3 RXRA SPTBN1 SRP54 TIPARP WARS2 WNT2B
Arm fat mass (right) 1.33 14 4 12.1 0.77 5.0e-04 AF131215.2 AMT C14orf39 CADM1 CORO6 DNAH10 ERI1 FAM86B3P HDAC5 MARK3 MTMR9 NEIL2 PPP1R3B ZNF608
Trunk predicted mass 2.24 27 19 57.6 0.26 1.4e-01 AF131215.2 C14orf39 CCDC66 CRIPAK CTBP1-AS2 DLEU2 DNAH10 DOCK9 EBPL FAM86B3P FGFRL1 FHL3 GATAD1 GHR IBSP IGHMBP2 MYH7B PPP6R3 RP13-514E23.2 RXRA SLCO2B1 SUPT3H UVSSA ZNF169 ZNF408 ZNF774 ZNF827
Standing height 1.90 35 25 75.8 0.02 8.8e-01 AP4E1 C14orf39 C7orf58 CCDC66 CORO6 CRIPAK CTD-2540B15.12 DLEU2 DNAH10 DOCK9 EBPL EPDR1 ERI1 FADS2 FGFRL1 FHL3 GATAD1 GHR HSD17B13 LIN7C MARK3 MTMR9 MYH7B PPP6R3 RP13-514E23.2 RXRA SLCO2B1 SUPT3H TPCN2 UVSSA WNT2B ZNF169 ZNF408 ZNF774 ZNF827
Tense / 'highly strung' 2.22 5 3 9.1 -0.83 2.1e-02 AF131215.2 ERI1 FAM86B3P MTMR9 RERE
Hair/balding pattern: Pattern 4 1.42 7 3 9.1 -0.19 6.8e-01 CTCF FADS2 MYH7B SMG6 SUPT3H WARS2 ZNF774
Birth weight of first child 1.37 4 0 0.0 -0.29 7.1e-01 NEIL2 TIPARP ZNF169 ZNF774
Peak expiratory flow (PEF) 1.65 6 2 6.1 -0.61 1.9e-01 AF131215.2 BMP4 DLEU2 ERI1 MTMR9 PPP6R3
Headache pain in last month 1.21 1 0 0.0 0.00 1.0e+00 PPP1R3B
Glaucoma (self-reported) 1.41 1 1 3.0 0.00 1.0e+00 C14orf39
Gout (self-reported) 1.17 2 0 0.0 0.00 1.0e+00 RXRA SIPA1
Hypothyroidism/myxoedema (self-reported) 1.71 7 3 9.1 -1.00 2.2e-07 AF131215.2 AKAP11 ERI1 FADS2 FAM86B3P MTMR9 PPP1R3B
Birth weight 1.83 4 2 6.1 0.96 4.1e-02 KREMEN1 PPP6R3 SMG6 TIPARP
High blood pressure (siblings) 1.22 1 0 0.0 0.00 1.0e+00 CORO6
Forced vital capacity (FVC), Best measure 1.51 11 4 12.1 0.03 9.2e-01 CORO6 CRIPAK DLEU2 EBPL FHL3 PPP6R3 PTPDC1 RXRA UVSSA ZNF169 ZNF408
Body fat percentage 1.21 10 5 15.2 0.14 7.1e-01 AMT CORO6 DNAH10 HDAC5 MARK3 RERE RXRA SPTBN1 WNT2B ZNF608
Leg fat percentage (right) 1.27 11 4 12.1 0.17 6.3e-01 AMT CADM1 CORO6 DNAH10 ERI1 EYA4 FAM86B3P LGR4 PPP1R3B RERE WNT2B
Arm fat-free mass (right) 2.19 25 14 42.4 0.49 3.5e-03 AF131215.2 C14orf39 CRIPAK CTBP1-AS2 DLEU2 DNAH10 DOCK9 EBPL ERI1 FAM86B3P FGFRL1 FHL3 GATAD1 GHR IBSP IGHMBP2 MYH7B NEIL2 PPP6R3 RP13-514E23.2 RXRA SMG6 SUPT3H UVSSA ZNF608
Comparative body size at age 10 1.67 11 6 18.2 0.78 1.7e-03 AF131215.2 ERI1 FAM86B3P IGHMBP2 L3MBTL2 MTMR9 NEIL2 PPP1R3B PPP6R3 SIPA1 WNT2B
Worry too long after embarrassment 1.71 5 3 9.1 -1.00 2.4e-07 AF131215.2 ERI1 FAM86B3P MTMR9 NEIL2
Wheeze or whistling in the chest in last year 1.14 1 0 0.0 0.00 1.0e+00 RERE
Age at first live birth 1.20 2 0 0.0 0.00 1.0e+00 AF131215.2 LOC338758
Qualifications: College or University degree 0.76 4 1 3.0 0.43 5.7e-01 AMT CADM1 MYH7B RERE
Emphysema/chronic bronchitis 1.19 1 0 0.0 0.00 1.0e+00 ERI1
Medication: Blood pressure 1.30 3 0 0.0 0.00 1.0e+00 ERI1 FTH1P20 SIPA1
Medication: Ibuprofen 1.20 1 0 0.0 0.00 1.0e+00 FTH1P20
Medication: Allopurinol 1.20 1 0 0.0 0.00 1.0e+00 LSMD1
Mean time to correctly identify matches 0.93 1 1 3.0 0.00 1.0e+00 ZNF408
Whole body fat mass 1.26 13 3 9.1 0.50 7.0e-02 AF131215.2 AMT C14orf39 CORO6 DNAH10 ERI1 FAM86B3P HDAC5 MARK3 PPP1R3B RERE WNT2B ZNF608
Leg fat mass (right) 1.41 15 3 9.1 0.45 7.0e-02 AF131215.2 AMT CADM1 CORO6 DNAH10 ERI1 FAM86B3P LGR4 MARK3 MTMR9 NEIL2 PPP1R3B RERE WNT2B ZNF608
Arm predicted mass (right) 2.23 26 14 42.4 0.50 2.2e-03 AF131215.2 C14orf39 CRIPAK CTBP1-AS2 DLEU2 DNAH10 DOCK9 EBPL ERI1 FAM86B3P FGFRL1 FHL3 GATAD1 GHR IBSP IGHMBP2 MYH7B NEIL2 PPP1R3B PPP6R3 RP13-514E23.2 RXRA SMG6 SUPT3H UVSSA ZNF608
Pulse rate, automated reading 1.79 11 4 12.1 0.19 5.1e-01 AMT CCDC66 CRIPAK FADS2 IGHMBP2 LEKR1 MYH7B NAE1 RHPN2 SERTAD2 UVSSA
Alcohol intake frequency. 0.68 1 0 0.0 0.00 1.0e+00 AMT
Comparative height size at age 10 1.45 19 11 33.3 0.06 7.7e-01 C14orf39 CRIPAK CTBP1-AS2 DLEU2 DNAH10 EBPL FGFRL1 FHL3 GATAD1 MARK3 PPP6R3 SLCO2B1 SUPT3H UVSSA WARS2 WNT2B ZNF169 ZNF408 ZNF774
Suffer from 'nerves' 1.89 6 0 0.0 -0.99 7.1e-07 AF131215.2 ERI1 FAM86B3P MTMR9 SMG6 ZNF408
Overall health rating 1.17 3 0 0.0 0.00 1.0e+00 AF131215.2 LOC338758 ZNF608
Chest pain or discomfort 0.88 1 0 0.0 0.00 1.0e+00 CADM1
Age at last live birth 1.61 1 0 0.0 0.00 1.0e+00 NEIL2
Medication: Aspirin 1.18 1 0 0.0 0.00 1.0e+00 FTH1P20
Hypertension (Self-reported) 1.95 10 6 18.2 0.46 9.8e-02 AF131215.2 AP4E1 ERI1 FTH1P20 KREMEN1 LSMD1 MTMR9 NEIL2 RP13-514E23.2 SIPA1
Illnesses of father: Heart disease 1.02 1 0 0.0 0.00 1.0e+00 DNAH10
Forced expiratory volume in 1-second (FEV1), predicted 1.58 3 1 3.0 0.00 1.0e+00 C14orf39 DLEU2 FHL3
Whole body fat-free mass 2.16 26 16 48.5 0.41 1.7e-02 AF131215.2 C14orf39 CRIPAK CTBP1-AS2 DLEU2 DNAH10 DOCK9 EBPL ERI1 FAM86B3P FGFRL1 FHL3 GATAD1 GHR IBSP IGHMBP2 MYH7B NEIL2 PPP6R3 RP13-514E23.2 RXRA SUPT3H UVSSA ZNF408 ZNF608 ZNF827
Leg fat-free mass (right) 2.01 25 14 42.4 0.46 7.4e-03 AF131215.2 AP4E1 C14orf39 CRIPAK CTBP1-AS2 DLEU2 DOCK9 EBPL ERI1 FAM86B3P FHL3 GATAD1 GHR IBSP IGHMBP2 MTMR9 MYH7B NEIL2 PPP6R3 RP13-514E23.2 SLCO2B1 SUPT3H UVSSA ZNF408 ZNF608
Arm fat percentage (left) 1.30 11 5 15.2 0.72 8.7e-03 AF131215.2 AMT CADM1 CORO6 DNAH10 ERI1 FAM86B3P HDAC5 MARK3 PPP1R3B RERE
Mood swings 1.54 3 1 3.0 -1.00 2.4e-04 AF131215.2 ERI1 MTMR9
Asthma (self-reported) 1.31 2 2 6.1 0.00 1.0e+00 FADS2 RERE
Osteoporosis (self-reported) 4.26 7 5 15.2 -0.32 4.8e-01 CPED1 DNAH10 GREM2 LIN7C PFDN5 PPP6R3 SPP1
Medication: Aspirin 1.26 1 0 0.0 0.00 1.0e+00 FTH1P20
Smoking status: Current 1.39 3 0 0.0 0.00 1.0e+00 AF131215.2 FAM86B3P MTMR9
Whole body water mass 2.17 26 16 48.5 0.43 1.0e-02 AF131215.2 C14orf39 CRIPAK CTBP1-AS2 DLEU2 DNAH10 DOCK9 EBPL ERI1 FAM86B3P FGFRL1 FHL3 GATAD1 GHR IBSP IGHMBP2 MYH7B NEIL2 PPP6R3 RP13-514E23.2 RXRA SUPT3H UVSSA ZNF408 ZNF608 ZNF827
Leg predicted mass (right) 2.00 25 13 39.4 0.43 1.2e-02 AF131215.2 AP4E1 C14orf39 CRIPAK DLEU2 DOCK9 EBPL ERI1 FAM86B3P FHL3 GATAD1 GHR IBSP IGHMBP2 MTMR9 MYH7B NEIL2 PPP6R3 RP13-514E23.2 SLCO2B1 SUPT3H UVSSA ZNF408 ZNF608 ZNF827
Arm fat mass (left) 1.36 14 5 15.2 0.77 4.4e-04 AF131215.2 AMT CADM1 CBL CORO6 DNAH10 ERI1 FAM86B3P HDAC5 MARK3 MTMR9 NEIL2 PPP1R3B ZNF608
Number of self-reported non-cancer illnesses 1.25 2 0 0.0 0.00 1.0e+00 CORO6 LSMD1
Miserableness 1.78 7 3 9.1 -1.00 3.5e-09 AF131215.2 ERI1 FAM86B3P MTMR9 NEIL2 PPP1R3B ZNF408
Guilty feelings 1.56 5 0 0.0 -0.99 1.1e-05 AF131215.2 ERI1 FAM86B3P MTMR9 NEIL2
Hearing aid user 1.12 1 0 0.0 0.00 1.0e+00 AC093110.3
Eye problems/disorders: Glaucoma 1.78 1 1 3.0 0.00 1.0e+00 C14orf39
Medication: Blood pressure 2.00 7 3 9.1 0.82 1.8e-03 AF131215.2 ERI1 LSMD1 MTMR9 NEIL2 SIPA1 WNT2B
High cholesterol (Self-reported) 1.09 2 0 0.0 0.00 1.0e+00 INSIG2 MS4A7
Medication: Bendroflumethiazide 2.03 4 3 9.1 0.98 1.8e-04 AF131215.2 ERI1 MTMR9 NEIL2
Illnesses of father: High blood pressure 1.29 1 0 0.0 0.00 1.0e+00 RP13-514E23.2
Basal metabolic rate 2.04 26 17 51.5 0.45 6.9e-03 AF131215.2 C14orf39 CBL CRIPAK CTBP1-AS2 DLEU2 DOCK9 EBPL ERI1 FAM86B3P FGFRL1 FHL3 GATAD1 GHR IBSP IGHMBP2 MYH7B NEIL2 PPP6R3 RP13-514E23.2 SLCO2B1 SUPT3H UVSSA ZNF408 ZNF608 ZNF827
Leg fat percentage (left) 1.24 11 4 12.1 0.28 4.1e-01 AMT CADM1 CORO6 DNAH10 ERI1 FAM86B3P LGR4 MARK3 PPP1R3B RERE WNT2B
Arm fat-free mass (left) 2.15 26 13 39.4 0.44 8.7e-03 AF131215.2 C14orf39 CBL CRIPAK CTBP1-AS2 DLEU2 DNAH10 DOCK9 EBPL ERI1 FAM86B3P FGFRL1 FHL3 GATAD1 GHR IBSP IGHMBP2 MYH7B NEIL2 PPP6R3 RP13-514E23.2 RXRA SUPT3H UVSSA ZNF608 ZNF827
Average weekly beer plus cider intake 1.45 3 0 0.0 0.00 1.0e+00 AF131215.2 ERI1 MTMR9
Irritability 2.50 5 5 15.2 -1.00 1.8e-09 AF131215.2 ERI1 FAM86B3P MTMR9 NEIL2
Fractured/broken bones in last 5 years 5.21 10 4 12.1 -0.99 2.8e-13 C7orf58 CPED1 CRIPAK CTBP1-AS2 FAM3C FGFRL1 HDAC5 IGHMBP2 LOC338758 RSPO3
Diastolic blood pressure, automated reading 2.13 13 8 24.2 0.69 2.3e-03 AF131215.2 AMT ERI1 FAM86B3P LSMD1 MTMR9 NEIL2 PPP1R3B RERE RP13-514E23.2 SIPA1 SMG6 WNT2B
Unable to work because of sickness or disability 0.97 1 0 0.0 0.00 1.0e+00 CADM1
Myopia 1.31 2 0 0.0 0.00 1.0e+00 BMP4 FADS2
Vascular/heart problems diagnosed by doctor 1.84 10 6 18.2 -0.50 6.9e-02 AF131215.2 ERI1 FTH1P20 KREMEN1 LSMD1 MARK3 MTMR9 NEIL2 SIPA1 ZNF408
Cholesterol lowering medication 1.18 2 0 0.0 0.00 1.0e+00 CORO6 DNAH10
Pain experienced in last month 1.03 1 0 0.0 0.00 1.0e+00 ECHDC1
Supplements: Calcium 1.94 1 0 0.0 0.00 1.0e+00 LOC338758
Basal cell carcinoma (self-reported) 1.30 1 0 0.0 0.00 1.0e+00 PPP6R3
Impedance of whole body 2.15 25 15 45.5 -0.52 3.4e-03 AF131215.2 C14orf39 CADM1 CRIPAK CTBP1-AS2 CTD-2540B15.12 DHX58 DNAH10 ERI1 FAM86B3P FZD7 GHR IBSP IGHMBP2 INSIG2 L3MBTL2 MARK3 MTMR9 MYH7B NEIL2 PPP1R3B PPP6R3 RXRA WARS2 WNT2B
Leg fat mass (left) 1.41 15 4 12.1 0.53 3.0e-02 AF131215.2 AMT CADM1 CBL CORO6 DNAH10 ERI1 FAM86B3P MARK3 MTMR9 NEIL2 PPP1R3B RERE WNT2B ZNF608
Arm predicted mass (left) 2.18 27 15 45.5 0.46 4.4e-03 AF131215.2 C14orf39 CBL CRIPAK CTBP1-AS2 DLEU2 DNAH10 DOCK9 EBPL ERI1 FAM86B3P FGFRL1 FHL3 GATAD1 GHR IBSP IGHMBP2 MYH7B NEIL2 PPP1R3B PPP6R3 RP13-514E23.2 RXRA SUPT3H UVSSA ZNF608 ZNF827

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 24 0.687 2.36
GTEx Adipose Visceral Omentum 16 0.786 2.46
GTEx Adrenal Gland 8 0.549 2.21
GTEx Artery Aorta 31 1.041 2.42
GTEx Artery Coronary 5 0.423 2.29
GTEx Artery Tibial 31 0.824 2.63
GTEx Brain Caudate basal ganglia 5 0.543 2.38
GTEx Brain Cerebellar Hemisphere 8 0.537 2.28
GTEx Brain Cerebellum 11 0.555 2.20
GTEx Brain Cortex 6 0.580 2.36
GTEx Brain Frontal Cortex BA9 6 0.649 2.29
GTEx Brain Hippocampus 3 0.573 2.44
GTEx Brain Hypothalamus 1 0.169 2.10
GTEx Brain Nucleus accumbens basal ganglia 7 0.809 2.11
GTEx Brain Putamen basal ganglia 4 0.641 2.34
GTEx Breast Mammary Tissue 13 0.659 2.39
GTEx Breast Mammary Tissue (Male) 8 0.671 2.24
GTEx Breast Mammary Tissue (Female) 10 0.608 2.22
GTEx Cells EBV-transformed lymphocytes 7 0.492 2.36
GTEx Cells Transformed fibroblasts 21 0.500 2.28
GTEx Colon Sigmoid 4 0.274 2.24
GTEx Colon Transverse 16 0.775 2.16
GTEx Esophagus Gastroesophageal Junction 11 0.761 2.32
GTEx Esophagus Mucosa 20 0.602 2.22
GTEx Esophagus Muscularis 24 0.743 2.27
GTEx Heart Atrial Appendage 8 0.507 2.24
GTEx Heart Left Ventricle 13 0.850 2.35
GTEx Liver 3 0.418 2.00
GTEx Lung 21 0.731 2.36
GTEx Muscle Skeletal 14 0.484 2.05
GTEx Nerve Tibial 29 0.671 2.34
GTEx Ovary 5 0.551 2.38
GTEx Pancreas 21 1.287 2.70
GTEx Pituitary 5 0.448 2.32
GTEx Prostate 6 0.719 2.39
GTEx Skin Not Sun Exposed Suprapubic 19 0.773 2.37
GTEx Skin Sun Exposed Lower leg 24 0.659 2.41
GTEx Small Intestine Terminal Ileum 3 0.651 2.49
GTEx Spleen 10 0.709 2.34
GTEx Stomach 7 0.481 2.30
GTEx Testis 21 0.666 2.24
GTEx Thyroid 22 0.550 2.32
GTEx Uterus 3 0.529 2.52
GTEx Vagina 6 0.945 2.37
GTEx Whole Blood 10 0.502 2.15
METSIM Adipose 38 0.824 2.21
NTR Blood 19 0.791 2.36
ROSMAP Brain Pre-frontal Cortex 43 0.979 2.46
YFS Blood 21 0.455 1.98
CommonMind Brain Pre-frontal Cortex 37 0.688 2.20
TCGA Breast Tumor 8 1.043 2.63
TCGA Breast Normal 17 0.404 2.03
TCGA Ovarian Tumor 25 0.856 2.14
TCGA Prostate Tumor 29 0.838 2.26