Hub : Genes

JARID2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Caudate basal ganglia	0.1540	0.0630	1.0e-02	0.023	NA	0.029	NA	0.010	7.0e-02	NA	5.2e-02	NA	1.6e-01
2	GTEx	Nerve Tibial	0.2270	0.0644	1.2e-04	0.076	NA	0.049	NA	0.027	4.7e-06	NA	2.1e-04	NA	4.6e-03
3	GTEx	Uterus	0.6780	0.1230	3.8e-04	-0.009	NA	0.017	NA	0.030	5.3e-01	NA	1.5e-01	NA	8.3e-02
4	METSIM	Adipose	0.0581	0.0252	2.6e-03	0.001	0.015	0.010	0.015	0.005	2.4e-01	2.3e-03	8.7e-03	1.9e-03	5.0e-02
5	NTR	Blood	0.0401	0.0125	9.8e-06	0.030	0.018	0.025	0.024	0.027	3.6e-10	9.8e-07	1.1e-08	2.4e-08	3.4e-09
6	ROSMAP	Brain Pre-frontal Cortex	0.1383	0.0305	1.6e-10	0.109	0.088	0.115	0.116	0.131	7.1e-14	2.3e-11	1.2e-14	1.2e-14	1.5e-16
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0399	0.0210	8.5e-03	-0.002	0.016	0.002	NA	-0.002	8.3e-01	6.0e-03	1.8e-01	NA	6.7e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.4	0.7	1.3	-1.1	-0.8	-1.1	0.1	-0.4	-1.0	-0.7
Bipolar Disorder or Schizophrenia	0.4	1.0	2.5	0.3	-0.5	-1.4	-1.2	0.0	-0.9	-1.6
Depressed Affect (Nagel 2018)	0.2	0.5	1.5	-0.1	-1.1	-0.6	0.2	1.2	-0.7	-0.1
Depression (Nagel 2018)	1.2	1.8	5.2	-0.3	-2.3	-1.7	-0.9	0.7	-1.6	-0.7
Intelligence (Savage-Jansen 2018)	1.3	4.1	8.4	-0.3	2.1	2.9	-0.7	-0.5	2.5	2.9
Neuroticism (Nagel 2018)	0.5	1.2	3.9	-1.3	-1.5	0.0	0.3	0.5	-2.0	-0.6
Schizophrenia (2018)	0.6	1.2	2.5	1.3	0.0	-1.1	-1.6	0.7	-0.3	-1.5
Schizophrenia vs Biploar Disorder	1.6	2.1	4.6	2.1	-1.0	-1.9	-1.8	1.0	-0.3	-1.3
Worry (Nagel 2018)	1.4	2.9	9.3	-2.4	-1.9	1.0	0.8	-0.1	-3.0	-0.0
Alzheimer’s Disease (in mother)	0.5	0.6	2.4	-0.5	-1.5	0.4	0.0	-0.3	-1.0	0.1
Alzheimer’s Disease (in father)	1.2	1.2	4.8	1.3	-0.2	-2.2	-0.5	-0.1	0.8	-1.1
Alzheimer’s Disease (including proxy)	0.2	0.4	1.7	1.3	-0.7	-0.3	-0.2	-0.2	0.4	-0.1
Crohns Disease (2017)	0.6	1.4	3.3	-0.6	1.4	1.8	-0.3	-0.9	1.6	0.8
Irritable Bowel Disease (IBD)	0.5	1.1	4.2	-1.1	0.4	1.3	0.4	-2.0	0.6	0.0
Ulcerative Colitis (UC)	0.5	1.0	4.1	-1.2	-0.3	0.4	0.6	-2.0	-0.4	-0.7
Major Depression (MDD)	0.5	0.6	3.2	0.3	-0.3	-0.4	-0.2	0.7	-0.4	-1.8
Reaction Time	1.6	3.1	6.3	0.8	-1.2	-2.5	1.1	2.0	-1.6	-2.4
Verbal and Numeric Reasoning (VNR)	1.0	2.5	7.7	-0.1	1.0	2.8	-1.1	0.5	2.0	1.7
Breast Cancer	1.2	2.9	10.0	3.2	1.1	-0.7	1.3	1.3	2.3	-0.5
Ovarian Cancer	0.8	1.1	2.9	0.0	1.7	1.2	-0.8	-0.4	1.6	0.4
Prostate Cancer	0.5	0.7	1.5	1.1	1.2	-0.8	-0.5	0.6	0.6	0.2
Age at First Birth	0.6	0.9	2.2	-1.0	1.5	0.7	-0.9	-1.2	0.0	-0.4
Bipolar Disorder (2011)	1.0	1.0	5.6	-0.3	-0.5	-2.4	0.3	-0.2	0.5	0.8
Body Mass Index (BMI) (2010)	0.3	0.3	1.1	0.7	0.1	-0.8	-0.1	1.0	-0.4	0.3
Coronary Artery Disease (CAD)	0.4	0.5	1.9	0.6	0.5	1.4	0.8	0.1	-0.4	0.3
Crohns Disease (2012)	0.4	0.7	1.7	-0.7	-0.7	-0.7	-1.0	-1.3	-0.3	-0.6
Mean Putamen Volume	0.8	1.0	3.2	-0.7	0.3	1.8	0.5	-1.5	-0.4	-0.6
Fasting Glucose	1.2	1.4	3.0	-1.3	-0.7	-1.2	1.7	-1.7	-0.3	-0.5
HbA1C	1.6	1.8	5.7	0.6	1.4	-0.4	-0.0	0.3	2.0	2.4
HDL Cholesterol	0.1	0.1	0.3	-0.6	0.0	-0.5	-0.1	0.2	-0.1	0.2
LDL Cholesterol	0.4	0.6	2.1	0.8	0.5	-1.0	0.1	1.4	0.0	0.7
Lupus	0.6	0.9	2.0	0.6	1.2	0.6	1.1	-0.1	1.4	0.8
Neuroticism (2016)	0.7	1.1	2.3	-0.3	-1.4	-1.4	-0.2	0.3	-1.1	-1.5
Primary Biliary Cirrhosis	0.6	0.9	2.8	-1.7	-1.1	0.1	-0.0	-0.0	-1.3	0.5
Rheumatoid Arthritis	1.4	1.9	7.6	1.3	0.9	0.9	-0.7	-2.7	1.3	0.4
Schizophrenia (2014)	0.8	1.7	2.9	0.1	-1.7	-1.6	-1.7	0.4	-1.3	-1.5
Triglycerides	0.4	0.7	2.7	1.7	-0.7	0.0	-0.9	0.5	0.3	-0.6
Type 2 Diabetes (T2D) (2012)	1.3	1.5	2.9	-1.4	-1.7	0.9	0.4	-0.2	-1.7	1.3
Ulcerative Colitis	0.8	1.2	3.5	-0.7	-1.3	-1.4	-0.2	-1.9	-0.7	-0.0
Blood Eosinophil Count	0.3	2.7	7.0	2.6	0.5	-1.5	-1.0	2.1	1.7	-1.1
Blood Platelet Count	0.1	1.6	4.5	2.1	0.6	0.3	-0.0	2.0	-1.2	-0.9
Blood Red Count	1.5	14.9	88.5	-2.7	-0.2	1.6	-2.0	-9.4	-0.3	1.1
Blood White Count	0.3	1.9	5.4	-2.2	-1.3	-0.8	0.6	-0.5	-2.3	0.0
Heel T-Score	0.7	5.4	12.6	-2.2	1.4	1.3	2.5	-2.7	3.5	1.7
BMI	1.1	6.4	18.1	0.9	-2.7	-3.1	-0.5	4.3	-1.3	-2.7
Height	0.2	4.3	12.0	2.8	3.5	1.0	0.8	0.9	2.7	-1.0
Waist Hip Ratio (WHR)	1.4	6.3	14.5	0.4	-3.0	-0.7	-1.5	3.5	-3.8	-2.2
Systolic Blood Pressure	1.1	5.4	9.1	-3.0	-0.8	2.6	2.1	-2.9	-2.7	1.0
Smoking Status	0.2	0.4	1.8	0.7	0.1	0.5	-1.3	-0.1	-0.4	-0.3
Allergy or Eczema	0.4	1.2	3.8	1.8	0.3	-1.9	0.5	0.3	0.8	-0.2
Cardiovascular Disease	3.2	10.7	37.9	-3.6	-4.6	0.2	-0.3	1.4	-6.2	0.2
Hypothyroidism (self reported)	0.9	2.0	8.0	-2.8	1.2	1.4	0.5	-0.2	-0.3	1.3
Respiratory disease	0.3	0.6	1.1	-0.9	-1.0	-0.1	0.3	1.1	-1.0	-0.2
Type 2 Diabetes (T2D) (2018)	2.5	4.7	15.0	-0.9	-1.8	-1.5	-0.6	1.6	-3.9	-3.0
Lung FEV1/FVC ratio	0.5	2.3	7.7	1.1	0.4	-1.6	0.6	0.9	1.9	2.8
Lung FVC	0.5	2.5	11.8	1.0	-0.5	-0.4	-0.3	-3.4	-0.9	-1.7
Neuroticism	1.2	3.0	10.6	-2.0	-2.3	-0.2	0.5	0.5	-3.3	-0.5
Chronotype (morning person)	0.8	1.9	4.3	-1.4	-1.0	-0.4	0.4	1.2	-2.1	-2.1
Hair Pigment	0.1	4.3	11.8	-0.2	1.1	-0.4	2.1	2.8	3.4	2.1
Tanning	0.2	2.7	8.3	1.3	1.7	1.0	1.2	0.1	2.9	1.9
Hand grip strength (left)	2.9	7.6	14.5	0.9	3.8	2.8	1.4	-2.4	3.8	2.9
Number of treatments/medications taken	2.4	4.3	12.8	-2.8	-2.7	-1.1	-0.5	-0.4	-3.6	-0.8
Average weekly spirits intake	1.0	1.2	2.6	-0.3	-1.1	-1.6	-1.3	-1.5	-0.8	-0.0
Sensitivity / hurt feelings	0.9	1.6	5.2	-0.3	-1.5	-0.3	-0.7	-1.1	-2.3	-1.4
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.5	0.7	-0.4	-1.2	-0.4	0.4	-0.7	-0.5
Hearing difficulty/problems: Yes	1.0	1.6	5.4	-1.4	-1.6	-0.6	0.4	0.6	-0.1	2.3
Relative age of first facial hair	0.8	1.7	7.0	-2.6	-0.3	1.3	1.2	-0.9	-0.3	-0.9
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	2.4	0.7	0.1	-1.3	-1.2	1.5	-0.6	-0.5
Ever used hormone-replacement therapy (HRT)	0.7	0.8	3.5	0.9	-1.0	-1.9	-0.1	0.4	0.4	-0.5
Ever had hysterectomy (womb removed)	2.0	2.3	6.0	-0.8	-1.7	-2.5	-0.9	0.7	-1.6	-1.6
Systolic blood pressure, automated reading	0.9	2.6	5.1	-1.2	0.9	2.2	2.0	-2.1	0.5	1.5
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	2.0	-0.3	0.1	0.9	-1.2	0.6	-1.4	0.2
Angina	0.8	1.1	3.3	-0.3	-0.5	-0.9	-1.0	1.4	-1.8	-0.5
Medication for hormone replacement therapy	0.5	0.6	1.7	-0.6	-0.8	-0.9	-1.3	0.4	-0.6	0.4
Vitamin and mineral supplements	0.6	0.8	2.9	1.7	-0.3	-0.2	-0.7	1.4	0.2	-0.3
Supplements: Zinc	1.1	1.2	3.4	-0.1	1.4	0.3	-0.6	-1.6	1.8	-0.6
Medication: Co-codamol	0.7	0.8	3.1	-1.2	-0.4	0.5	0.1	-0.8	0.0	1.8
Medication: Metformin	1.6	2.2	7.7	-0.0	-1.1	-0.9	-0.6	0.9	-2.8	-2.2
Diabetes (father)	0.2	0.2	0.6	-0.8	-0.4	0.4	0.0	-0.6	-0.4	-0.3
Diabetes (mother)	0.9	1.1	3.2	0.1	1.0	0.5	1.8	1.6	0.7	0.4
Severe depression (siblings)	0.8	0.9	3.6	-1.2	-1.9	-0.0	0.5	-0.6	-0.9	0.4
Pack years adult smoking proportion	0.8	1.1	2.7	1.3	-1.1	-1.2	-0.5	1.6	-0.4	-0.8
Impedance of leg (right)	0.7	3.5	13.0	-3.6	-1.2	1.2	-0.8	-1.2	-2.5	0.8
Leg fat-free mass (left)	0.8	4.5	12.5	3.5	1.5	-1.4	0.6	2.8	2.2	-1.2
Trunk fat percentage	1.3	5.3	7.6	-0.6	-2.6	-2.8	-2.2	2.6	-2.2	-2.3
Hand grip strength (right)	4.1	11.3	29.1	1.8	4.7	3.0	1.1	-1.7	5.4	3.4
Townsend deprivation index at recruitment	0.6	0.9	3.2	0.2	-1.4	-0.4	0.6	1.8	-0.2	-0.5
Current tobacco smoking	0.5	0.8	2.8	-0.2	-1.2	-0.9	-1.7	0.8	-0.4	-0.4
Average weekly fortified wine intake	0.5	0.6	1.8	-1.2	-0.4	0.4	0.6	-1.3	-0.5	0.2
Maternal smoking around birth	1.4	2.0	5.3	2.3	-0.9	-1.9	-0.5	1.2	-0.6	-1.6
Fed-up feelings	0.1	0.3	0.5	0.7	-0.5	-0.2	-0.7	0.5	-0.3	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.5	0.7	-1.2	-0.6	0.3	1.6	-1.0	-0.1
Relative age voice broke	2.5	3.8	14.9	-3.9	-0.9	1.7	2.3	0.8	-1.0	1.1
Taking other prescription medications	0.5	0.7	2.2	-1.5	-0.1	-1.0	-0.5	0.6	-1.0	-0.1
Age when periods started (menarche)	1.0	2.4	7.6	-0.5	-1.0	-1.0	0.4	-0.4	-2.8	-2.5
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	4.1	0.2	0.3	-1.0	-1.6	0.7	-0.7	-2.0
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	3.0	0.3	0.2	-0.9	1.3	0.5	1.7	0.8
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	4.1	0.4	-0.5	0.9	0.7	-1.6	0.3	2.0
Qualifications: CSEs or equivalent	0.7	0.9	3.2	0.4	-0.8	0.3	-0.3	-1.8	-1.4	-0.6
Serious illness, injury or assault to yourself	0.9	1.1	5.0	-1.0	0.8	-0.8	0.7	2.2	0.0	0.1
High blood pressure	2.9	8.2	26.6	-3.3	-4.3	0.7	-0.6	0.6	-5.2	-0.5
Hayfever, allergic rhinitis or eczema	0.9	2.0	5.3	2.2	1.1	-2.3	0.3	0.6	1.4	-0.5
Multivitamins +/- minerals	0.7	0.9	3.0	-1.7	0.0	-0.2	0.3	-1.1	-0.8	-1.1
Stomach or abdominal pain in last month	0.7	0.9	3.4	-1.0	-0.9	0.2	-0.7	-0.3	-1.8	-0.7
Supplements: Glucosamine	1.3	1.6	4.9	-2.2	-0.6	0.0	1.4	-1.8	-0.2	1.1
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	3.3	0.7	-1.3	-1.8	0.6	1.6	0.3	-0.4
Medication: Atenolol	2.7	3.3	10.1	-1.6	-2.4	1.9	0.5	-1.1	-3.2	0.3
Medication: Levothyroxine sodium	0.5	0.8	2.2	-0.5	0.8	1.4	0.2	0.5	0.7	1.5
Sitting height	0.9	6.1	18.5	2.9	3.8	1.2	0.1	-0.1	4.3	-0.6
Chronic bronchitis/emphysema (father)	0.7	0.8	2.7	0.3	-0.6	0.8	1.6	0.5	-0.6	1.1
High blood pressure (mother)	1.8	2.6	7.2	-1.0	-2.7	-1.7	-0.2	1.6	-2.0	-0.4
Body mass index (BMI)	0.7	2.9	9.5	0.9	-1.4	-2.3	-0.5	3.1	-0.1	-1.6
Impedance of leg (left)	0.8	3.9	16.6	-4.1	-1.0	1.2	-1.0	-1.6	-2.0	1.0
Leg predicted mass (left)	0.9	4.6	13.0	3.6	1.6	-1.4	0.5	2.8	2.3	-1.1
Trunk fat mass	0.8	3.6	7.7	0.5	-1.5	-2.5	-1.7	2.8	-0.8	-2.3
Waist circumference	1.4	5.1	16.3	1.2	-1.6	-2.2	-0.6	4.0	-1.3	-2.9
Number of incorrect matches in round	3.9	6.5	16.7	-0.1	-3.6	-2.3	-0.8	1.4	-4.1	-2.8
Past tobacco smoking	0.7	1.2	2.8	-1.7	0.1	-0.2	1.3	0.9	1.0	1.5
Alcohol usually taken with meals	2.2	3.5	10.6	-1.2	1.6	2.4	0.7	-1.8	0.9	3.3
Nervous feelings	0.9	1.7	6.2	-1.4	-1.7	0.3	0.7	-0.0	-2.5	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.5	0.6	-0.2	-0.7	0.4	-0.4	-0.6	-0.6
Hearing difficulty/problems with background noise	1.6	2.5	7.0	-1.0	-2.6	-2.3	-1.6	1.1	-0.5	0.5
Hair/balding pattern: Pattern 2	0.5	0.7	2.9	-0.6	0.9	1.7	0.0	0.5	0.7	-0.3
Had menopause	0.6	0.8	2.3	-0.6	-1.0	-1.5	0.0	0.8	0.3	-1.0
Had other major operations	0.7	0.8	1.9	0.9	1.1	-0.8	0.4	0.9	1.4	0.1
Forced vital capacity (FVC)	0.6	2.5	7.3	2.0	2.7	0.5	0.3	-1.6	1.7	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	5.8	0.3	1.1	-0.8	0.8	0.5	2.4	1.5
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	4.1	1.2	1.1	1.3	0.5	2.0	-0.4	-0.3
Qualifications: None of the above	0.4	0.9	2.0	1.1	-0.2	-1.4	0.9	0.8	0.0	-1.2
Financial difficulties in last 2 years	1.0	1.4	3.6	-1.4	-1.9	-0.4	0.3	1.2	-1.4	0.7
Mouth/teeth dental problems	1.2	1.8	6.1	-0.3	1.9	-0.3	1.1	0.5	2.5	1.1
Heart attack	0.6	0.7	1.5	-0.6	-1.1	-1.2	-0.3	0.4	-1.1	-0.9
Allergy	0.5	1.1	2.8	-1.5	0.2	1.7	-0.8	-1.2	-0.7	0.2
Pain all over the body in last month	2.5	2.7	5.8	-2.4	-2.0	0.9	0.0	0.8	-2.4	1.5
Diabetes (self-reported)	2.2	3.4	9.9	0.1	-1.1	-0.4	-1.9	0.3	-3.1	-3.0
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	2.1	0.5	0.7	-0.8	0.7	1.4	0.6	-0.0
Medication: Ramipril	1.7	2.2	4.9	-0.4	-2.2	-1.5	-1.0	0.6	-2.2	-1.5
Medication: Simvastatin	2.7	4.0	13.5	0.0	-2.0	-0.0	-2.5	0.8	-3.7	-2.0
Fluid intelligence score	1.1	2.3	5.5	-0.8	0.7	2.3	-1.4	0.4	1.6	2.2
Illnesses of siblings	0.2	0.2	0.6	0.2	0.7	0.7	0.3	-0.1	0.3	0.8
Neuroticism score	0.9	1.9	7.6	-1.1	-1.8	-0.3	0.8	0.4	-2.8	-0.8
Weight	0.7	3.6	9.5	2.3	0.4	-2.0	-0.3	3.1	1.3	-2.0
Impedance of arm (right)	0.8	3.9	12.1	-2.1	-1.7	-0.6	-2.4	-0.6	-3.5	-1.0
Arm fat percentage (right)	1.6	6.5	11.0	-0.0	-2.9	-3.3	-2.1	3.2	-2.1	-2.7
Trunk fat-free mass	1.2	7.0	17.8	3.6	3.3	-0.3	1.8	1.9	4.2	-0.3
Hip circumference	0.5	2.3	6.3	1.1	-0.2	-2.0	0.7	2.5	0.9	-1.7
Time employed in main current job	0.3	0.3	1.2	0.2	-0.7	0.0	-0.7	-0.3	-0.2	-1.1
Alcohol intake versus 10 years previously	1.0	1.4	5.9	1.0	-1.0	-1.1	-2.4	-0.5	0.3	-0.6
Father’s age at death	0.8	1.1	3.3	0.2	1.8	1.0	0.8	-0.3	0.1	-1.6
Worrier / anxious feelings	0.7	1.3	5.6	-1.2	-1.1	0.6	-0.0	-0.6	-2.4	-0.4
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	3.3	0.1	-1.8	-1.0	0.0	1.8	-1.6	-1.3
Falls in the last year	1.6	2.1	4.2	-1.7	-2.1	-1.9	0.4	1.3	-1.4	-0.5
Hair/balding pattern: Pattern 3	0.5	0.7	2.2	0.2	-0.1	-1.3	-0.4	1.5	-0.4	0.7
Number of live births	0.3	0.4	1.3	-0.0	-0.1	-1.1	-0.3	-0.9	-0.8	-0.3
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	7.6	2.1	2.8	-0.0	0.3	-1.2	2.3	0.6
Pulse rate	0.8	1.4	2.7	-0.9	1.4	0.9	1.6	-1.2	1.4	-0.5
Happiness	0.6	0.7	2.9	0.8	-0.6	-0.6	-1.7	-0.4	-0.5	0.1
Noisy workplace	0.9	1.1	3.2	-1.7	-1.8	0.1	0.5	0.2	-0.7	-0.8
Qualifications: A levels/AS levels or equivalent	0.8	1.7	6.9	-1.0	0.3	1.8	-0.2	-0.6	0.6	2.6
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	1.0	-0.7	0.4	-0.0	-0.1	0.7	-0.2	-1.0
Mouth/teeth dental problems: Dentures	0.7	1.2	3.9	0.9	-1.0	1.1	0.9	-2.0	-0.9	-0.5
Asthma	0.4	0.7	2.4	-0.9	-1.0	0.4	0.6	1.6	-0.5	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.9	0.0	-0.0	-0.6	0.7	-0.6	0.9	0.5
Medication: Cholesterol lowering	1.9	2.9	9.5	-0.5	-2.0	-0.7	-2.1	1.0	-3.1	-0.7
Depression (self-reported)	0.6	0.7	2.5	-1.6	0.3	-0.0	0.6	1.1	-0.0	0.7
Medication: Lansoprazole	0.6	0.7	2.7	-1.1	0.1	-0.2	0.2	-1.6	0.4	1.0
Prospective memory result	1.7	2.1	5.1	0.1	-1.3	-0.4	-1.8	1.2	-1.8	-2.2
Lung cancer (father)	0.2	0.2	0.6	-0.4	-0.6	-0.8	-0.4	0.4	-0.2	-0.4
Illnesses of mother	0.9	1.1	3.0	-0.6	1.5	1.3	-0.7	-1.7	0.3	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	4.2	1.1	1.9	-0.3	0.2	-2.1	1.9	0.7
Pulse wave Arterial Stiffness index	1.9	2.2	7.2	-1.4	-1.6	-2.7	-0.7	0.2	-0.4	-1.8
Impedance of arm (left)	0.6	2.8	9.4	-1.6	-1.4	-0.6	-2.1	-0.8	-3.1	-0.7
Arm fat mass (right)	1.0	4.1	10.8	0.9	-1.9	-2.7	-1.4	3.3	-0.5	-1.9
Trunk predicted mass	1.3	7.2	18.1	3.7	3.4	-0.2	1.9	1.9	4.2	-0.3
Standing height	0.5	5.4	15.8	3.1	4.0	0.4	0.7	0.7	3.3	-0.9
Length of working week for main job	0.8	0.9	4.8	-0.6	-0.2	-2.2	-0.2	0.5	-0.2	-0.8
Exposure to tobacco smoke at home	0.5	0.6	1.3	-1.1	-0.7	0.6	1.0	-0.6	0.7	0.5
Breastfed as a baby	1.2	1.5	3.1	1.5	0.1	1.3	-1.7	-1.8	0.2	0.3
Tense / ‘highly strung’	1.3	2.2	4.4	-1.5	-1.9	-0.1	1.0	2.1	-2.1	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.3	5.8	-2.4	-0.8	0.7	1.4	1.7	-1.9	0.6
Hair/balding pattern: Pattern 4	0.7	1.8	4.7	1.3	-0.4	1.2	-2.2	-1.8	-0.2	1.1
Birth weight of first child	0.7	1.3	5.9	2.4	0.0	0.2	-0.9	1.0	0.1	-1.0
Peak expiratory flow (PEF)	2.7	6.3	13.6	0.9	2.8	1.2	2.0	-2.1	3.5	3.7
Pulse wave reflection index	3.0	3.7	9.9	-0.8	-3.2	-2.6	-1.7	-0.2	-1.3	-2.0
Ever highly irritable/argumentative for 2 days	1.6	1.9	4.0	0.1	-1.6	-1.3	-2.0	-0.2	-1.8	-1.3
Loud music exposure frequency	1.3	1.4	5.0	0.7	-2.2	0.6	-1.2	-0.5	-0.7	1.4
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.2	-0.1	0.1	0.7	-0.9	-1.4	0.3	1.5
Mouth/teeth dental problems: Bleeding gums	1.7	2.3	5.8	0.2	-1.0	0.5	-1.9	-0.7	-2.2	-2.4
Blood clot in the leg (DVT)	0.7	0.9	2.5	1.2	-0.9	-1.6	-1.0	0.1	-0.2	-0.7
Medication: Paracetamol	0.4	0.7	1.6	-0.7	-0.6	-0.8	0.7	-0.6	-1.3	-0.8
Headache pain in last month	1.3	2.2	5.4	-2.3	-1.1	-1.3	1.3	1.2	-1.1	1.7
Medication for cholesterol, blood pressure or diabetes	2.6	4.3	18.3	0.7	2.4	-0.2	2.1	-0.8	4.3	0.6
Glaucoma (self-reported)	1.4	1.6	2.9	-1.4	-1.2	-1.1	1.7	-1.1	-0.1	1.6
Gout (self-reported)	1.5	2.1	5.9	-2.4	-2.3	0.2	-0.7	-0.5	-1.3	0.8
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.2	-1.2	1.5	1.1	1.0	0.0	0.4	1.4
Medication: Amlodipine	0.8	1.1	3.6	-0.5	-1.0	0.1	-0.4	-1.0	-1.9	-1.2
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.4	1.2	-0.9	-0.7	-0.5	1.2	-0.2	-0.7
Birth weight	1.2	2.5	7.9	2.8	1.2	0.0	-0.7	-1.8	1.3	-1.8
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.3	0.6	-0.2	0.6	-0.6	-0.0	0.2	-0.4
High blood pressure (siblings)	0.2	0.2	0.5	-0.4	-0.7	-0.3	-0.6	-0.2	-0.2	-0.6
Forced vital capacity (FVC), Best measure	0.6	2.2	7.3	1.1	2.0	-0.1	0.6	-2.7	1.4	-0.8
Body fat percentage	1.3	5.1	7.8	-0.7	-2.5	-2.8	-1.9	2.8	-2.1	-2.4
Leg fat percentage (right)	1.1	3.9	7.0	-1.0	-2.6	-2.1	-1.3	2.6	-1.6	-1.9
Arm fat-free mass (right)	1.0	4.9	12.3	2.9	2.5	-0.3	1.8	2.1	3.5	-0.6
Exposure to tobacco smoke outside home	0.7	0.9	2.3	-1.0	0.0	1.5	1.0	-0.0	-0.1	-1.4
Comparative body size at age 10	1.8	4.9	11.1	3.3	0.3	-2.5	-1.4	3.0	-0.1	-2.3
Number of full brothers	0.4	0.4	2.5	-0.1	0.4	1.6	-0.0	-0.3	-0.6	-0.0
Worry too long after embarrassment	0.8	1.4	2.7	1.1	0.5	-0.5	0.6	1.5	-1.6	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	2.0	6.4	-2.5	-1.5	-0.3	0.3	0.3	-2.2	0.1
Wheeze or whistling in the chest in last year	0.3	0.6	1.7	0.9	-0.9	-0.1	-0.4	0.6	-0.7	-1.3
Number of children fathered	0.6	0.7	2.4	1.2	-1.6	0.0	-0.2	-0.7	-0.3	0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	4.2	0.1	-1.4	-1.7	-0.8	-0.5	-0.7	-2.0
Age at first live birth	1.4	2.6	6.5	-0.1	2.2	2.5	-0.8	-0.3	1.5	2.0
Pulse wave peak to peak time	2.0	2.4	6.2	1.6	1.9	2.5	0.7	-0.1	0.6	1.8
Health satisfaction	1.2	1.5	5.6	-1.5	-0.9	-0.7	-0.9	0.8	-2.4	-0.4
Shortness of breath walking on level ground	0.5	0.6	1.8	-0.3	-0.6	0.4	-0.8	-0.2	-1.4	-0.9
Qualifications: College or University degree	0.8	2.6	6.2	-0.6	2.0	0.3	0.6	2.5	1.5	2.1
Eye problems/disorders: None of the above	0.6	0.6	2.3	-0.0	1.5	0.5	0.3	0.6	0.6	1.1
Mouth/teeth dental problems: Loose teeth	1.6	1.9	7.8	-0.4	-2.8	0.7	-0.7	-0.4	-2.0	0.6
Emphysema/chronic bronchitis	0.5	0.6	2.2	0.4	0.1	1.1	-0.6	-1.5	0.1	0.2
Medication for pain relief, constipation, heartburn	1.0	1.7	3.4	1.8	1.7	1.2	-0.6	-0.3	1.9	0.9
Neck or shoulder pain in last month	1.8	2.6	6.0	-1.5	-2.4	-2.2	-1.0	0.3	-1.9	-0.2
Medication: Blood pressure	3.8	6.7	23.8	-1.9	-3.9	-0.0	-1.8	0.9	-4.9	-0.5
Angina (self-reported)	0.9	1.2	3.5	-0.3	-0.6	-0.9	-1.1	1.6	-1.9	-0.5
Migraine (self-reported)	1.7	2.1	5.2	0.1	1.5	-0.1	2.1	0.4	1.6	2.3
Medication: Ibuprofen	0.5	0.6	2.9	-0.9	-0.0	-0.7	1.7	-0.2	0.6	-0.0
Medication: Allopurinol	4.4	5.8	15.2	-3.5	-3.9	0.8	0.0	-0.6	-3.5	0.6
Medication: Omeprazole	1.6	1.9	4.7	-1.0	-2.2	-1.3	-1.2	0.1	-2.0	0.1
Medication: Seretide 50 evohaler	0.5	0.6	2.2	0.4	0.7	1.5	1.0	0.2	-0.5	0.2
Mean time to correctly identify matches	1.4	2.6	5.9	0.6	-1.0	-2.0	1.5	1.8	-1.2	-2.4
Heart disease (mother)	0.9	1.1	3.1	-0.3	-1.8	-0.9	1.2	1.4	-0.7	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.5	1.8	-0.6	-0.5	0.2	-1.4	0.6	-0.9	-0.2
Whole body fat mass	1.0	4.0	9.4	0.6	-1.6	-2.7	-1.3	3.1	-0.8	-2.4
Leg fat mass (right)	0.9	3.6	10.6	0.4	-1.9	-2.2	-1.1	3.2	-0.6	-2.1
Arm predicted mass (right)	1.0	4.9	12.1	2.9	2.5	-0.5	1.6	2.3	3.5	-0.5
Pulse rate, automated reading	0.2	0.5	3.0	-0.3	0.6	-0.3	-0.5	-0.1	0.2	-1.7
Alcohol intake frequency.	0.2	0.4	1.4	0.5	1.2	1.0	0.2	-0.2	-0.3	0.1
Comparative height size at age 10	0.6	3.3	11.6	3.4	1.4	-0.8	-0.7	-2.1	1.8	-1.0
Number of full sisters	1.1	1.3	3.9	2.0	0.9	-0.6	-1.4	-0.1	0.3	-1.4
Suffer from ‘nerves’	1.0	1.5	4.2	-2.0	-0.6	-0.2	1.8	0.7	-1.5	-0.3
Overall health rating	2.1	4.6	8.5	-2.0	-2.3	-2.2	-0.8	2.9	-2.9	-0.7
Chest pain or discomfort	0.6	0.9	2.3	0.0	-1.4	0.8	0.5	1.0	-1.5	0.1
Had major operations	0.7	0.9	4.5	-0.1	1.1	0.4	0.2	2.1	0.2	0.1
Age at last live birth	0.9	1.3	3.3	-0.6	1.8	1.8	0.3	-0.3	0.9	0.9
Family relationship satisfaction	2.2	2.6	6.9	-1.1	-2.6	0.0	-1.9	-0.1	-2.5	0.7
Leg pain on walking	1.4	1.7	6.1	-0.8	-2.1	0.5	0.6	-0.3	-2.5	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.7	-0.2	-1.0	-0.9	0.0	-0.5	-0.1	-1.6
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.4	-0.6	0.3	0.6	0.8	-1.2	0.7	-0.1
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	6.2	1.3	1.3	0.4	-0.3	-2.5	0.7	-0.3
Medication: Aspirin	2.1	2.7	6.0	-1.3	-1.5	-2.5	-0.1	1.6	-2.1	-1.4
Supplements: Vitamin C	1.5	1.8	5.0	-2.2	-1.6	0.5	1.2	-0.4	-0.4	1.8
Knee pain experienced in last month	1.4	2.2	6.5	-0.7	-2.5	-0.4	-2.2	-0.6	-1.7	-0.3
Hypertension (Self-reported)	3.1	8.5	28.5	-3.2	-4.4	0.4	-0.5	0.6	-5.3	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.4	-0.5	-1.0	0.5	-0.1	-1.6	-0.9	0.2
Illnesses of father: Heart disease	0.6	0.8	3.0	-0.5	-1.7	-0.8	1.3	-0.2	-0.4	-0.3
Illnesses of siblings: Diabetes	0.5	0.6	1.4	-1.2	0.9	0.9	0.7	0.4	-0.5	0.0
Smoking status: Previous	0.6	0.8	3.3	1.8	0.6	0.8	-0.5	-1.0	-0.3	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	2.3	0.1	0.8	-0.3	1.5	0.2	0.8	0.1
Whole body fat-free mass	1.1	6.2	13.8	3.7	2.8	-0.7	1.4	2.2	3.7	-0.7
Leg fat-free mass (right)	0.9	4.5	12.2	3.5	1.9	-1.2	0.5	2.4	2.8	-0.8
Arm fat percentage (left)	1.5	5.8	10.9	0.2	-2.8	-3.3	-1.9	3.0	-1.9	-2.4
Average weekly red wine intake	0.3	0.4	1.3	1.1	0.4	-0.5	-1.0	0.7	0.1	0.1
Handedness (chirality/laterality): Left-handed	1.9	2.3	5.3	0.0	-2.2	-0.5	-1.0	0.0	-2.3	-2.2
Mood swings	0.1	0.1	0.5	0.0	-0.3	0.2	0.2	-0.1	-0.7	-0.2
Loneliness, isolation	0.9	1.3	4.7	-0.3	-0.8	-0.8	1.3	2.2	-0.6	-1.0
Long-standing illness, disability or infirmity	1.2	1.8	7.8	-0.2	-1.0	-1.6	-0.9	2.8	-0.8	-0.3
Ever had bowel cancer screening	1.0	1.2	4.3	-0.5	-0.5	-1.0	-1.0	2.1	-0.8	-0.8
Diabetes diagnosed by doctor	2.0	3.3	9.2	0.0	-0.9	-0.8	-1.7	1.2	-3.0	-2.9
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	5.2	1.1	-0.6	0.1	0.4	-2.3	-0.6	-1.7
Friendships satisfaction	1.3	1.6	4.4	-0.6	-2.1	-0.7	-1.7	-0.8	-1.7	0.2
Qualifications: nursing, teaching	1.1	1.7	3.8	-0.2	1.6	1.6	1.6	0.2	1.9	0.6
Commuting to job workplace: Walk	0.2	0.2	0.6	-0.1	-0.1	-0.3	-0.4	0.4	0.5	0.8
Eye problems/disorders: Cataract	0.8	0.9	2.3	1.5	1.0	0.2	0.1	0.1	1.0	-1.3
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	6.0	1.1	-0.1	-1.1	-1.5	2.4	-1.4	-0.9
Medication for cholesterol	4.7	7.1	22.7	2.2	3.8	0.9	0.8	-1.9	4.8	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.4	5.9	-1.8	-1.4	-2.4	-1.1	-0.0	-1.8	-1.0
Back pain experienced in last month	2.1	3.0	11.8	2.3	-0.5	-3.4	-0.8	1.2	0.4	-1.4
Mineral and other dietary supplements	1.3	1.8	7.1	1.9	0.8	0.2	0.6	2.7	0.2	-0.9
Breast cancer (self-reported)	0.7	0.9	3.6	-1.2	-0.5	0.0	1.9	0.7	-0.6	0.3
Asthma (self-reported)	0.4	0.9	3.5	-0.8	-1.0	0.1	0.7	1.9	-0.7	-0.0
Osteoporosis (self-reported)	1.7	2.1	5.8	-2.4	-1.0	1.6	0.5	-0.9	-1.5	1.4
Osteoarthritis (self-reported)	0.6	0.7	2.5	-1.6	-0.1	0.1	0.1	0.4	-0.3	1.6
Medication: Aspirin	1.8	2.3	4.8	-1.2	-1.6	-1.8	0.2	1.5	-2.2	-1.4
Medication: Gliclazide	0.4	0.5	1.4	-0.1	-0.0	-0.1	-0.8	1.2	-0.7	-0.9
Illnesses of father: None of the above (group 1)	0.9	1.1	2.6	1.1	1.5	0.2	-0.5	1.6	1.0	-0.2
Smoking status: Current	0.4	0.7	2.3	-0.4	-1.0	-0.8	-1.5	0.5	-0.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	3.8	0.2	1.3	0.9	-0.5	-2.0	0.9	1.7
Whole body water mass	1.1	6.1	13.6	3.7	2.8	-0.7	1.3	2.3	3.7	-0.7
Leg predicted mass (right)	0.9	4.6	12.7	3.6	1.9	-1.3	0.5	2.4	2.7	-0.9
Arm fat mass (left)	0.9	3.9	10.4	1.1	-1.6	-2.7	-1.1	3.2	-0.4	-2.1
Number of self-reported non-cancer illnesses	1.2	2.1	4.6	-2.1	-1.1	-1.2	-0.1	1.6	-2.0	-1.0
Average weekly champagne plus white wine intake	0.3	0.4	1.5	-0.3	0.6	0.2	1.2	-0.8	-0.1	0.6
Miserableness	0.8	1.4	3.3	0.7	-1.3	-0.7	-0.6	1.2	-1.8	-1.5
Guilty feelings	0.3	0.5	1.8	1.4	0.9	0.1	0.7	-0.6	0.3	-0.4
Wears glasses or contact lenses	1.4	1.6	6.1	0.2	-0.1	-2.0	0.2	-0.7	-0.7	-2.5
Ever taken oral contraceptive pill	0.7	0.8	2.2	-0.2	-0.8	0.5	-0.7	0.1	-1.5	-1.4
Hearing aid user	2.4	2.7	7.6	-2.1	-1.3	-2.8	1.2	1.7	-0.9	0.6
Mother’s age at death	0.9	1.1	3.9	-0.7	1.4	0.5	1.1	-0.1	2.0	0.3
Financial situation satisfaction	1.0	1.2	3.8	0.9	-1.6	-0.9	0.5	-0.7	-2.0	0.0
Tinnitus: Yes, now most or all of the time	1.0	1.2	4.5	-1.4	-2.1	-0.3	-0.7	-0.7	0.0	1.0
Commuting to job workplace: Public transport	0.7	0.8	2.0	-0.1	1.4	0.4	0.7	0.5	1.4	1.0
Eye problems/disorders: Glaucoma	1.1	1.3	2.8	-1.4	-1.2	-0.5	0.7	-1.7	0.1	1.5
Medication: Blood pressure	2.3	4.3	12.2	-2.3	-3.3	-0.1	0.8	0.6	-3.5	-0.5
Pain type(s) experienced in last month: Hip pain	1.3	1.6	7.7	-0.4	-0.9	-0.4	1.1	2.8	-1.0	0.8
Supplements: Fish oil (including cod liver oil)	1.7	2.2	11.7	-1.6	-0.1	0.1	-0.0	-3.4	0.3	0.8
High cholesterol (Self-reported)	1.6	2.9	5.9	0.1	-2.4	-1.0	-1.8	0.7	-2.4	-2.0
Medication: Bendroflumethiazide	1.4	2.1	5.9	-0.7	-2.2	-1.4	-0.3	-0.6	-2.4	-1.1
Medication: Paracetamol	0.9	1.3	3.3	-0.8	-0.4	-1.3	1.8	-0.0	-1.3	-1.3
Medication: Lisinopril	2.6	3.3	11.4	-1.8	-2.5	0.8	-0.8	1.0	-3.4	0.5
Medication: Atorvastatin	0.4	0.5	1.4	-0.2	-0.8	-0.7	0.6	0.6	0.5	1.2
Illnesses of father: High blood pressure	1.2	1.5	6.1	-2.5	-0.3	1.1	0.6	-0.7	-0.6	1.3
Alcohol drinker status: Never	2.1	2.5	6.1	-0.2	2.5	2.0	1.8	0.5	1.9	0.1
Ever smoked	0.8	1.3	3.2	1.2	-0.4	-0.2	-1.3	-0.7	-1.6	-1.8
Basal metabolic rate	1.0	5.4	11.9	3.5	2.3	-1.0	1.1	2.6	3.3	-0.9
Leg fat percentage (left)	0.9	3.4	5.6	-1.3	-2.3	-2.2	-1.3	2.4	-1.3	-1.7
Arm fat-free mass (left)	0.8	4.2	10.2	2.7	2.2	-0.5	1.3	2.1	3.2	-0.9
Number of operations (self-reported)	1.6	2.4	7.9	1.0	1.8	-1.4	-0.5	2.8	1.5	0.2
Average weekly beer plus cider intake	0.6	0.8	2.3	1.5	-0.3	0.7	-1.2	0.6	0.9	-0.6
Irritability	0.3	0.6	1.3	-1.1	-1.1	-0.5	-0.7	0.6	-0.5	-0.5
Risk taking	0.3	0.4	1.4	0.0	0.2	1.2	-0.5	-0.8	0.4	0.4
Ever had prostate specific antigen (PSA) test	0.7	0.9	1.8	1.2	1.2	-0.6	0.1	-1.0	1.3	0.3
Fractured/broken bones in last 5 years	0.8	1.0	2.9	-0.2	-0.3	0.6	1.7	0.1	-1.2	-1.6
Age started oral contraceptive pill	1.2	1.5	3.9	-0.7	-1.6	0.3	1.3	-2.0	-1.0	-0.9
Diastolic blood pressure, automated reading	0.5	1.5	4.7	-2.2	-0.3	0.8	1.7	-1.3	-0.7	0.1
Ever depressed for a whole week	0.9	1.1	3.9	0.9	1.1	-0.1	0.6	2.0	-0.2	-1.4
Unable to work because of sickness or disability	1.1	1.4	2.8	0.2	-0.3	-1.2	-0.4	1.6	-1.6	-1.7
Commuting to job workplace: Cycle	2.3	2.7	7.8	2.8	2.5	0.9	-0.6	1.5	1.2	0.5
Myopia	1.0	1.4	3.2	-0.2	-1.4	-0.8	-0.4	1.4	-1.8	-1.3
Vascular/heart problems diagnosed by doctor	2.7	7.3	25.5	2.5	3.8	0.2	0.6	-1.7	5.0	1.1
Cholesterol lowering medication	1.6	2.4	5.1	0.1	-2.2	-1.1	-0.6	0.8	-2.3	-2.2
Medication: Omeprazole (e.g. Zanprol)	1.6	1.9	5.3	-0.9	-2.3	-1.3	-1.6	0.1	-1.8	0.1
Pain experienced in last month	1.1	1.9	4.1	1.5	1.8	1.6	0.4	0.1	2.0	0.8
Supplements: Calcium	1.2	1.4	6.2	1.0	1.0	0.9	-0.3	-0.1	0.5	2.5
Basal cell carcinoma (self-reported)	0.6	0.7	2.1	-0.1	1.2	0.8	-0.0	-0.7	-0.4	-1.4
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.1	-0.4	-1.2	-1.4	-0.4	0.4	-1.2	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.4	1.0	-0.8	-1.5	-0.8	0.1	-0.4	-0.5
Heart disease (siblings)	1.3	1.6	4.4	-0.1	-1.7	-0.7	0.4	-0.1	-2.1	-1.8
Alcohol drinker status: Previous	0.6	0.6	1.2	-0.7	0.9	-0.2	-0.2	-1.0	-1.1	-1.0
Pack years of smoking	1.1	1.6	3.0	1.6	-1.3	-1.5	-0.7	1.7	-0.3	-0.9
Impedance of whole body	0.7	3.8	9.6	-3.1	-1.4	0.3	-1.8	-1.5	-3.1	-0.1
Leg fat mass (left)	0.8	3.2	9.7	0.3	-1.7	-2.1	-1.2	3.1	-0.4	-1.9
Arm predicted mass (left)	0.9	4.7	12.0	2.7	2.2	-0.5	1.6	2.3	3.5	-0.8