Hub : Traits :

Neuroticism

738 significantly associated models · 154 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 7715776 9571422 2 1 1.2e-07 2.8e-07 3.6e-01 97 RERE
2 1 20434402 22200998 1 1 3.9e-07 2.9e-07 1.0e+00 100 EIF4G3
3 1 86635245 88077288 1 1 2.6e-07 9.6e-05 1.5e-04 5 SEP15
4 1 116905402 118340958 1 1 1.8e-08 1.4e-05 2.4e-05 5 TTF2
5 1 171053153 172474017 1 1 7.6e-11 4.6e-09 6.7e-03 79 METTL13
6 1 173103273 174823032 2 1 3.6e-08 2.9e-08 1.0e+00 100 RP11-160H22.5
7 1 201252866 202669883 1 1 1.4e-07 4.4e-07 2.5e-05 30 RNPEP
8 1 226385623 227873074 1 1 1.7e-07 8.6e-07 2.5e-02 79 ADCK3
9 2 23453834 24924438 1 1 2.1e-07 1.5e-07 1.8e-01 94 UBXN2A
10 2 86061013 87557137 2 1 3.7e-09 2.9e-08 3.3e-02 85 PLGLB1
11 2 147993969 149475737 1 1 2.1e-15 3.7e-17 2.9e-03 88 ORC4
12 2 171935729 173544743 2 1 9.1e-08 6.4e-07 5.4e-02 85 HAT1
13 2 215101843 216697115 1 1 8.2e-08 1.2e-09 2.5e-03 75 ABCA12
14 3 16154636 17814553 1 1 8.1e-10 1.2e-10 1.0e+00 100 PLCL2
15 3 48702606 51043528 6 2 1.7e-09 4.1e-07 1.0e+00 100 GPX1 U73166.2
16 3 51860817 53623102 5 1 6.9e-08 6.6e-08 1.0e+00 100 NT5DC2
17 3 135273949 137423165 4 1 5.2e-12 3.0e-12 1.0e+00 100 PCCB
18 4 14777384 16291144 1 1 1.8e-07 1.3e-06 1.0e-02 72 CC2D2A
19 4 41416242 42851723 1 1 2.2e-07 1.6e-07 5.6e-02 87 BEND4
20 4 89947254 91439574 1 1 7.1e-09 1.7e-09 1.0e+00 100 SNCA
21 5 86867897 88677293 2 4 1.3e-09 9.1e-11 NaN NaN LINC00461 TMEM161B-AS1
22 7 1580921 2977732 1 1 6.9e-08 5.4e-09 6.1e-04 66 FTSJ2
23 7 11553163 12967449 1 1 1.0e-07 7.4e-08 8.8e-02 90 TMEM106B
24 7 23913624 25432157 1 1 4.1e-07 4.4e-07 1.3e-03 59 MPP6
25 7 31804088 33193481 1 1 4.8e-08 3.0e-07 4.7e-02 85 AC018641.7
26 7 125383444 127590914 1 1 2.2e-09 2.9e-12 7.7e-06 59 GRM8
27 7 154388677 155777228 1 1 1.7e-08 8.4e-09 1.0e+00 100 AC144652.1
28 8 94046312 95443806 1 1 1.2e-08 2.9e-07 9.8e-01 100 RP11-10N23.4
29 9 95186937 96898436 2 3 2.2e-08 3.4e-09 1.3e-01 94 NINJ1 RP11-165J3.6
30 9 97520168 98975128 1 1 2.7e-10 3.8e-12 3.8e-03 83 PTCH1
31 9 119768572 121177842 1 1 1.9e-10 9.6e-12 5.7e-04 74 TLR4
32 9 126946822 128824378 4 1 1.2e-08 2.8e-08 1.0e+00 100 PPP6C
33 9 136197834 137631198 1 1 6.9e-08 7.7e-06 5.5e-06 -3 BRD3
34 10 103905779 105647095 3 1 1.2e-08 6.7e-09 1.0e+00 100 CNNM2
35 11 9105636 11013472 1 1 2.7e-07 2.7e-07 1.5e-02 78 SBF2
36 11 12611333 14105497 1 1 3.9e-13 1.5e-12 1.2e-01 95 ARNTL
37 11 46010847 48559571 13 6 2.6e-13 6.7e-11 NaN NaN ARHGAP1 C1QTNF4 LRP4 MADD MTCH2
38 11 56666189 58178587 3 1 4.0e-12 6.1e-12 1.0e+00 100 ZDHHC5
39 11 77215675 78828001 2 1 4.4e-09 3.8e-08 7.5e-02 90 GAB2
40 11 112135760 113969669 4 2 1.1e-17 2.5e-19 1.3e-11 43 ANKK1 NCAM1
41 11 133079948 134525648 1 1 7.2e-09 3.8e-10 1.3e-02 84 IGSF9B
42 12 108763672 110729807 5 1 2.0e-12 1.9e-12 1.3e-01 95 MMAB
43 12 118116461 119551378 1 1 1.8e-11 1.8e-11 1.0e+00 100 SUDS3
44 13 98409084 99925872 1 1 5.3e-08 1.8e-08 1.3e-02 80 STK24
45 14 69027866 70518587 1 1 1.8e-08 1.0e-09 1.4e-03 73 GALNT16
46 14 74245607 76226003 7 1 7.5e-16 1.2e-14 9.6e-03 89 RPS6KL1
47 15 66850204 68789191 2 1 1.8e-08 7.1e-09 1.0e+00 100 MAP2K5
48 15 77207277 78806023 1 1 3.1e-07 7.1e-09 2.5e-04 60 LINGO1
49 16 30347731 31892919 7 1 1.1e-09 3.5e-09 2.4e-01 96 STX1B
50 16 86667409 89448663 4 3 2.4e-08 9.4e-10 1.3e-04 61 MAP1LC3B MVD SNAI3-AS1
51 17 1805677 3287175 1 1 1.4e-07 5.5e-11 6.0e-06 52 PAFAH1B1
52 17 37483599 38906153 1 1 2.7e-07 3.0e-08 3.0e-03 71 MED24
53 17 42607368 45796313 23 1 2.6e-28 1.4e-26 7.0e-02 97 RP11-259G18.1
54 18 22896666 24367973 1 1 3.8e-07 3.5e-07 1.8e-03 62 SS18
55 18 33712354 35844220 2 2 5.4e-08 1.2e-18 4.4e-09 56 CELF4 KIAA1328
56 18 52209411 54028036 1 1 5.4e-12 1.1e-14 5.8e-07 58 TCF4
57 19 45799442 47218599 1 1 3.0e-08 2.5e-08 1.6e-01 94 CCDC61
58 20 17776692 19441650 3 1 3.5e-08 6.2e-08 4.0e-01 98 DTD1
59 20 32594714 34109427 2 1 1.3e-08 1.3e-06 9.5e-01 100 TP53INP2
60 20 43958786 45456440 2 1 6.0e-10 1.3e-09 3.0e-02 87 CD40
61 22 40472399 42614362 5 1 6.8e-10 1.1e-10 5.4e-02 91 RANGAP1
62 22 49939309 51219006 1 1 3.4e-07 4.0e-06 4.8e-05 22 TRABD

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (including proxy) 1.9 2 0 0.0 0.00 1.0e+00 C1QTNF4 MADD
Crohns Disease (2017) 1.1 2 2 6.1 0.00 1.0e+00 CD40 GPX1
Irritable Bowel Disease (IBD) 1.2 2 1 3.0 0.00 1.0e+00 CD40 GPX1
Ulcerative Colitis (UC) 1.2 1 1 3.0 0.00 1.0e+00 GPX1
Major Depression (MDD) 4.2 6 0 0.0 0.99 5.1e-05 BEND4 CNNM2 GPX1 TCF4 TMEM106B ZDHHC5
Reaction Time 2.0 3 2 6.1 0.00 1.0e+00 ARHGAP1 HAT1 LRP4
Verbal and Numeric Reasoning (VNR) 2.5 9 3 9.1 -0.23 5.2e-01 C1QTNF4 GPX1 LINC00461 MAP1LC3B METTL13 MTCH2 NCAM1 NINJ1 NT5DC2
Breast Cancer 1.2 2 1 3.0 0.00 1.0e+00 RP11-259G18.1 SBF2
Ovarian Cancer 1.1 1 1 3.0 0.00 1.0e+00 RP11-259G18.1
Prostate Cancer 1.5 1 0 0.0 0.00 1.0e+00 GPX1
Age at First Birth 1.4 1 1 3.0 0.00 1.0e+00 GPX1
Body Mass Index (BMI) (2010) 2.7 5 3 9.1 -0.99 3.2e-04 C1QTNF4 CNNM2 MADD MAP2K5 MTCH2
Coronary Artery Disease (CAD) 1.5 1 0 0.0 0.00 1.0e+00 CNNM2
Fasting Glucose 1.4 1 1 3.0 0.00 1.0e+00 MADD
HDL Cholesterol 2.0 5 2 6.1 0.44 3.8e-01 ARHGAP1 C1QTNF4 LRP4 MMAB MTCH2
Neuroticism 7.1 13 1 3.0 0.99 4.8e-11 C1QTNF4 GPX1 LINC00461 MADD MTCH2 RANGAP1 RPS6KL1 SBF2 STK24 SUDS3 TCF4 TLR4 U73166.2
Primary Biliary Cirrhosis 1.1 2 0 0.0 0.00 1.0e+00 PLCL2 RP11-259G18.1
Rheumatoid Arthritis 1.3 1 1 3.0 0.00 1.0e+00 CD40
Schizophrenia 2.6 5 2 6.1 0.63 2.6e-01 CNNM2 IGSF9B PCCB RERE ZDHHC5
Triglycerides 1.2 1 1 3.0 0.00 1.0e+00 TP53INP2
Ulcerative Colitis 1.3 1 1 3.0 0.00 1.0e+00 GPX1
Blood Eosinophil Count 1.2 9 6 18.2 -0.60 8.5e-02 BRD3 EIF4G3 GPX1 MAP2K5 ORC4 PLCL2 RANGAP1 RERE RP11-259G18.1
Blood Platelet Count 1.2 17 14 42.4 0.30 2.2e-01 AC144652.1 BRD3 C1QTNF4 GAB2 LINC00461 MADD MED24 METTL13 MTCH2 NINJ1 NT5DC2 PCCB RPS6KL1 SNAI3-AS1 U73166.2 UBXN2A ZDHHC5
Blood Red Count 2.2 18 13 39.4 0.46 5.2e-02 ARNTL BRD3 CC2D2A CNNM2 EIF4G3 GAB2 LINC00461 METTL13 MTCH2 MVD NT5DC2 RP11-160H22.5 RP11-259G18.1 SBF2 SNAI3-AS1 STX1B UBXN2A ZDHHC5
Blood White Count 1.7 13 7 21.2 -0.19 5.1e-01 C1QTNF4 CNNM2 GPX1 MADD MAP2K5 MED24 MTCH2 PCCB PTCH1 RERE SNAI3-AS1 TMEM161B-AS1 UBXN2A
Heel T-Score 2.1 13 8 24.2 -0.22 4.8e-01 ADCK3 ARHGAP1 CNNM2 DTD1 GAB2 LRP4 MADD NINJ1 RANGAP1 RERE RP11-160H22.5 RP11-259G18.1 ZDHHC5
BMI 3.1 19 12 36.4 -0.20 3.9e-01 AC018641.7 ANKK1 ARNTL C1QTNF4 CNNM2 FTSJ2 GAB2 GALNT16 GPX1 HAT1 LINC00461 MADD MAP2K5 MTCH2 PLGLB1 RP11-165J3.6 STK24 STX1B TLR4
Height 1.6 32 25 75.8 -0.09 6.1e-01 AC018641.7 BRD3 C1QTNF4 CD40 EIF4G3 FTSJ2 GAB2 GPX1 KIAA1328 MADD MED24 METTL13 MTCH2 MVD NT5DC2 PAFAH1B1 PCCB PTCH1 RERE RP11-160H22.5 RP11-165J3.6 RP11-259G18.1 RPS6KL1 SBF2 SNAI3-AS1 SNCA SS18 TCF4 TMEM106B TP53INP2 U73166.2 UBXN2A
Waist Hip Ratio (WHR) 1.6 11 7 21.2 0.60 5.3e-02 CC2D2A EIF4G3 GPX1 NINJ1 NT5DC2 PCCB PPP6C RP11-259G18.1 SBF2 U73166.2 UBXN2A
Systolic Blood Pressure 3.0 14 12 36.4 0.38 1.6e-01 ARHGAP1 ARNTL C1QTNF4 CNNM2 GPX1 LRP4 MADD MTCH2 PAFAH1B1 PPP6C RERE RP11-259G18.1 RPS6KL1 ZDHHC5
Smoking Status 2.7 7 4 12.1 -0.27 4.9e-01 GPX1 MAP1LC3B MAP2K5 PPP6C RERE RP11-259G18.1 TMEM161B-AS1
Allergy or Eczema 1.6 4 1 3.0 -0.23 7.7e-01 BEND4 PLCL2 RANGAP1 RERE
Cardiovascular Disease 1.9 9 2 6.1 -0.09 8.2e-01 ARNTL CNNM2 EIF4G3 FTSJ2 GAB2 MAP2K5 PCCB RERE STX1B
Hypothyroidism (self reported) 1.4 3 0 0.0 0.00 1.0e+00 C1QTNF4 MTCH2 RERE
Respiratory disease 1.5 3 1 3.0 0.00 1.0e+00 MVD RERE SNAI3-AS1
Type 2 Diabetes (T2D) 1.3 1 0 0.0 0.00 1.0e+00 C1QTNF4
Lung FEV1/FVC ratio 1.4 8 4 12.1 -0.41 3.1e-01 ADCK3 GAB2 PTCH1 RERE RP11-259G18.1 RPS6KL1 SBF2 ZDHHC5
Lung FVC 2.2 11 8 24.2 -0.31 3.5e-01 GPX1 MAP2K5 MVD PTCH1 RP11-259G18.1 SNAI3-AS1 STX1B TCF4 TP53INP2 U73166.2 UBXN2A
Chronotype (morning person) 2.3 6 2 6.1 -0.51 2.4e-01 C1QTNF4 EIF4G3 GAB2 TMEM161B-AS1 U73166.2 UBXN2A
Hair Pigment 2.3 9 7 21.2 0.27 4.9e-01 ADCK3 GAB2 MAP1LC3B MVD RANGAP1 RP11-259G18.1 SBF2 SNAI3-AS1 TP53INP2
Tanning 3.9 7 3 9.1 -0.30 4.7e-01 C1QTNF4 GAB2 MAP1LC3B MTCH2 MVD SNAI3-AS1 TP53INP2
Hand grip strength (left) 2.6 11 5 15.2 -0.05 8.8e-01 ADCK3 BRD3 C1QTNF4 IGSF9B LINGO1 MADD MTCH2 RP11-259G18.1 RPS6KL1 TCF4 UBXN2A
Number of treatments/medications taken 2.7 4 1 3.0 -1.00 1.7e-03 FTSJ2 GPX1 RP11-160H22.5 RPS6KL1
Sensitivity / hurt feelings 6.5 15 5 15.2 -0.98 1.8e-11 ANKK1 GRM8 KIAA1328 METTL13 MMAB NCAM1 ORC4 PCCB PLCL2 PPP6C PTCH1 RP11-165J3.6 RP11-259G18.1 SUDS3 ZDHHC5
Frequency of depressed mood in last 2 weeks 6.9 18 2 6.1 -0.97 1.8e-12 ANKK1 C1QTNF4 CC2D2A CELF4 MADD NCAM1 NINJ1 PCCB RERE RP11-10N23.4 RP11-165J3.6 RP11-259G18.1 STK24 SUDS3 TMEM106B U73166.2 UBXN2A ZDHHC5
Hearing difficulty/problems: Yes 1.6 1 0 0.0 0.00 1.0e+00 MMAB
Relative age of first facial hair 1.9 1 1 3.0 0.00 1.0e+00 RP11-259G18.1
Systolic blood pressure, automated reading 2.4 10 4 12.1 0.06 8.8e-01 ARNTL CNNM2 GPX1 LRP4 MADD PAFAH1B1 PPP6C RERE RP11-259G18.1 ZDHHC5
Eye problems/disorders: Diabetes related eye disease 1.8 1 0 0.0 0.00 1.0e+00 C1QTNF4
Medication: Metformin 1.5 2 0 0.0 0.00 1.0e+00 C1QTNF4 MTCH2
Pack years adult smoking proportion 1.6 1 0 0.0 0.00 1.0e+00 GPX1
Impedance of leg (right) 2.1 17 9 27.3 -0.58 1.5e-02 ADCK3 BEND4 C1QTNF4 CNNM2 GPX1 LINC00461 MADD NINJ1 NT5DC2 PPP6C PTCH1 RPS6KL1 SBF2 SNAI3-AS1 TP53INP2 U73166.2 UBXN2A
Leg fat-free mass (left) 1.4 11 6 18.2 0.60 5.1e-02 C1QTNF4 CNNM2 HAT1 LINC00461 MAP2K5 PPP6C PTCH1 SBF2 SNAI3-AS1 TP53INP2 UBXN2A
Trunk fat percentage 3.5 19 10 30.3 0.18 4.6e-01 ANKK1 ARNTL BEND4 C1QTNF4 FTSJ2 GALNT16 GPX1 LINC00461 MADD MAP2K5 MTCH2 RANGAP1 RERE RP11-259G18.1 RPS6KL1 SBF2 STK24 STX1B ZDHHC5
Hand grip strength (right) 1.9 8 3 9.1 -0.10 8.1e-01 BRD3 C1QTNF4 IGSF9B LINGO1 MADD MTCH2 RP11-259G18.1 TCF4
Townsend deprivation index at recruitment 2.2 2 0 0.0 0.00 1.0e+00 MAP2K5 MTCH2
Current tobacco smoking 2.4 5 0 0.0 -0.56 2.5e-01 C1QTNF4 MTCH2 PPP6C RANGAP1 UBXN2A
Fed-up feelings 6.8 23 8 24.2 -0.98 1.1e-15 ABCA12 AC144652.1 ARHGAP1 ARNTL GALNT16 GPX1 KIAA1328 LINC00461 LINGO1 LRP4 MADD MVD NCAM1 ORC4 PAFAH1B1 PCCB RP11-160H22.5 RP11-259G18.1 RPS6KL1 SEP15 TLR4 UBXN2A ZDHHC5
Frequency of unenthusiasm / disinterest in last 2 weeks 5.8 8 1 3.0 -0.99 7.0e-07 CELF4 EIF4G3 GALNT16 IGSF9B PCCB U73166.2 UBXN2A ZDHHC5
Relative age voice broke 1.7 1 1 3.0 0.00 1.0e+00 RP11-259G18.1
Taking other prescription medications 2.7 2 1 3.0 0.00 1.0e+00 GPX1 RPS6KL1
Age when periods started (menarche) 2.5 8 6 18.2 -0.80 9.3e-03 ARNTL BRD3 C1QTNF4 GAB2 GPX1 MADD MAP2K5 MTCH2
Heel bone mineral density (BMD) T-score, automated (left) 1.6 5 3 9.1 0.46 4.3e-01 ADCK3 ARHGAP1 LRP4 RANGAP1 RERE
High blood pressure 2.0 8 3 9.1 -0.31 4.5e-01 ARHGAP1 ARNTL CNNM2 EIF4G3 LRP4 MADD MAP2K5 RERE
Hayfever, allergic rhinitis or eczema 1.5 2 1 3.0 0.00 1.0e+00 BEND4 RERE
Sitting height 2.2 15 11 33.3 -0.05 8.6e-01 BRD3 C1QTNF4 MADD MED24 MTCH2 NT5DC2 PPP6C PTCH1 RP11-165J3.6 RP11-259G18.1 SBF2 SNAI3-AS1 TP53INP2 UBXN2A ZDHHC5
High blood pressure (mother) 1.6 1 1 3.0 0.00 1.0e+00 CNNM2
Body mass index (BMI) 3.0 13 9 27.3 0.28 3.4e-01 AC018641.7 ARNTL C1QTNF4 CNNM2 FTSJ2 GALNT16 GPX1 LINC00461 MADD MAP2K5 MTCH2 STK24 STX1B
Impedance of leg (left) 2.1 18 11 33.3 -0.40 9.6e-02 ADCK3 BEND4 C1QTNF4 CNNM2 FTSJ2 GPX1 LINC00461 MADD NINJ1 NT5DC2 PPP6C RP11-259G18.1 RPS6KL1 SBF2 SNAI3-AS1 TP53INP2 U73166.2 UBXN2A
Leg predicted mass (left) 1.5 11 6 18.2 0.60 5.0e-02 C1QTNF4 CNNM2 HAT1 LINC00461 MAP2K5 PPP6C PTCH1 SBF2 SNAI3-AS1 TP53INP2 UBXN2A
Trunk fat mass 2.6 15 8 24.2 0.30 2.6e-01 ANKK1 ARNTL C1QTNF4 CNNM2 GALNT16 GPX1 LINC00461 MADD MAP2K5 MTCH2 RANGAP1 RERE RP11-259G18.1 STK24 STX1B
Waist circumference 2.3 10 6 18.2 0.33 3.3e-01 ANKK1 ARNTL C1QTNF4 FTSJ2 LINC00461 MADD MAP2K5 MTCH2 STK24 STX1B
Number of incorrect matches in round 1.8 1 0 0.0 0.00 1.0e+00 EIF4G3
Past tobacco smoking 2.1 3 1 3.0 -0.58 3.1e-01 MAP2K5 PPP6C TMEM161B-AS1
Alcohol usually taken with meals 1.7 1 0 0.0 0.00 1.0e+00 ZDHHC5
Nervous feelings 6.6 23 7 21.2 -0.98 3.6e-16 ADCK3 ANKK1 ARNTL C1QTNF4 CELF4 CNNM2 DTD1 EIF4G3 MADD NT5DC2 ORC4 PCCB PPP6C RP11-259G18.1 RPS6KL1 SBF2 SNCA STK24 STX1B TMEM161B-AS1 TP53INP2 TTF2 U73166.2
Frequency of tenseness / restlessness in last 2 weeks 5.9 12 3 9.1 -0.99 1.7e-10 C1QTNF4 CELF4 CNNM2 GPX1 MADD MMAB NT5DC2 PCCB RP11-165J3.6 RP11-259G18.1 TMEM106B TP53INP2
Hearing difficulty/problems with background noise 2.4 3 0 0.0 0.00 1.0e+00 ARHGAP1 LRP4 PAFAH1B1
Hair/balding pattern: Pattern 2 1.6 1 1 3.0 0.00 1.0e+00 RP11-259G18.1
Forced vital capacity (FVC) 2.3 8 7 21.2 0.08 8.3e-01 C1QTNF4 GPX1 MTCH2 PTCH1 RP11-259G18.1 SNAI3-AS1 STX1B UBXN2A
Heel bone mineral density (BMD) T-score, automated (right) 1.8 4 3 9.1 0.50 5.0e-01 ADCK3 ARHGAP1 LRP4 RERE
Ever unenthusiastic/disinterested for a whole week 2.5 1 0 0.0 0.00 1.0e+00 RP11-259G18.1
Qualifications: None of the above 1.9 2 1 3.0 0.00 1.0e+00 GALNT16 GPX1
Allergy 1.5 2 1 3.0 0.00 1.0e+00 RANGAP1 RERE
Fluid intelligence score 2.1 5 1 3.0 -0.01 9.9e-01 C1QTNF4 GPX1 METTL13 MTCH2 PCCB
Neuroticism score 12.7 67 34 103.0 -0.99 2.9e-66 ABCA12 AC018641.7 AC144652.1 ADCK3 ANKK1 ARHGAP1 ARNTL BEND4 BRD3 C1QTNF4 CC2D2A CCDC61 CD40 CELF4 DTD1 EIF4G3 FTSJ2 GALNT16 GPX1 GRM8 IGSF9B KIAA1328 LINC00461 LINGO1 LRP4 MADD MAP1LC3B MED24 METTL13 MMAB MPP6 MTCH2 MVD NCAM1 NINJ1 NT5DC2 ORC4 PAFAH1B1 PCCB PLCL2 PLGLB1 PPP6C PTCH1 RANGAP1 RERE RNPEP RP11-10N23.4 RP11-160H22.5 RP11-165J3.6 RP11-259G18.1 RPS6KL1 SBF2 SNAI3-AS1 SNCA SS18 STK24 STX1B SUDS3 TCF4 TLR4 TMEM106B TMEM161B-AS1 TP53INP2 TTF2 U73166.2 UBXN2A ZDHHC5
Weight 1.6 11 6 18.2 0.35 2.7e-01 ANKK1 C1QTNF4 CNNM2 GPX1 HAT1 LINC00461 MADD MAP2K5 PPP6C STX1B TP53INP2
Impedance of arm (right) 1.9 14 8 24.2 -0.16 5.9e-01 ADCK3 GAB2 GPX1 LINC00461 NT5DC2 PPP6C RANGAP1 RP11-259G18.1 SBF2 TMEM106B TP53INP2 U73166.2 UBXN2A ZDHHC5
Arm fat percentage (right) 3.8 16 11 33.3 0.20 4.4e-01 AC018641.7 ANKK1 ARNTL C1QTNF4 CNNM2 FTSJ2 GPX1 LINC00461 MADD MAP2K5 MTCH2 RERE SBF2 STK24 STX1B ZDHHC5
Trunk fat-free mass 1.5 11 7 21.2 0.31 3.5e-01 ARHGAP1 BRD3 C1QTNF4 CNNM2 MTCH2 PPP6C PTCH1 RPS6KL1 SBF2 TP53INP2 UBXN2A
Hip circumference 2.1 12 8 24.2 0.36 2.2e-01 AC018641.7 C1QTNF4 CNNM2 FTSJ2 GPX1 LINC00461 MADD MAP2K5 MTCH2 PPP6C PTCH1 STX1B
Time employed in main current job 1.4 1 0 0.0 0.00 1.0e+00 RP11-259G18.1
Alcohol intake versus 10 years previously 2.0 1 0 0.0 0.00 1.0e+00 FTSJ2
Father's age at death 1.4 1 0 0.0 0.00 1.0e+00 GPX1
Worrier / anxious feelings 7.2 26 10 30.3 -0.98 4.2e-20 ADCK3 ARNTL CNNM2 DTD1 IGSF9B KIAA1328 LINGO1 METTL13 MMAB MPP6 NT5DC2 ORC4 PCCB PPP6C PTCH1 RANGAP1 RP11-165J3.6 RP11-259G18.1 RPS6KL1 STX1B TCF4 TLR4 TMEM161B-AS1 TTF2 U73166.2 ZDHHC5
Frequency of tiredness / lethargy in last 2 weeks 5.8 12 3 9.1 -0.99 2.1e-10 AC144652.1 ARHGAP1 C1QTNF4 GALNT16 GPX1 MMAB PAFAH1B1 RANGAP1 RP11-165J3.6 SNAI3-AS1 UBXN2A ZDHHC5
Hair/balding pattern: Pattern 3 1.8 1 1 3.0 0.00 1.0e+00 RP11-259G18.1
Number of live births 1.1 1 0 0.0 0.00 1.0e+00 RP11-259G18.1
Forced expiratory volume in 1-second (FEV1) 2.3 9 5 15.2 0.27 4.5e-01 C1QTNF4 GPX1 MTCH2 PPP6C PTCH1 RP11-259G18.1 SNAI3-AS1 STX1B UBXN2A
Pulse rate 1.4 2 0 0.0 0.00 1.0e+00 GAB2 SEP15
Qualifications: A levels/AS levels or equivalent 2.0 5 1 3.0 0.66 2.3e-01 GPX1 LINC00461 METTL13 NINJ1 RNPEP
Mouth/teeth dental problems: Dentures 1.6 4 0 0.0 -0.38 6.2e-01 ADCK3 GPX1 RP11-160H22.5 TP53INP2
Asthma 1.5 2 1 3.0 0.00 1.0e+00 MVD RERE
Medication: Ibuprofen (e.g. Nurofen) 1.7 1 0 0.0 0.00 1.0e+00 UBXN2A
Depression (self-reported) 2.9 3 0 0.0 0.00 1.0e+00 AC018641.7 RERE TMEM106B
Medication: Lansoprazole 1.5 1 0 0.0 0.00 1.0e+00 GALNT16
Forced expiratory volume in 1-second (FEV1), Best measure 2.2 8 5 15.2 0.16 6.8e-01 C1QTNF4 GPX1 MTCH2 PTCH1 RP11-259G18.1 SNAI3-AS1 STX1B UBXN2A
Impedance of arm (left) 1.9 11 9 27.3 -0.18 6.0e-01 GAB2 GPX1 NT5DC2 PPP6C RANGAP1 RP11-259G18.1 SBF2 TP53INP2 U73166.2 UBXN2A ZDHHC5
Arm fat mass (right) 2.8 12 8 24.2 0.29 3.4e-01 ANKK1 ARNTL C1QTNF4 CNNM2 FTSJ2 GPX1 LINC00461 MADD MAP2K5 MTCH2 STK24 STX1B
Trunk predicted mass 1.5 11 8 24.2 0.32 3.4e-01 ARHGAP1 BRD3 C1QTNF4 CNNM2 MTCH2 PPP6C PTCH1 RPS6KL1 SBF2 TP53INP2 UBXN2A
Standing height 1.7 22 16 48.5 0.11 6.0e-01 BRD3 C1QTNF4 EIF4G3 FTSJ2 GAB2 GPX1 MADD METTL13 MTCH2 NT5DC2 PAFAH1B1 PTCH1 RP11-165J3.6 RP11-259G18.1 RPS6KL1 SBF2 SNAI3-AS1 SNCA SS18 TMEM106B TP53INP2 UBXN2A
Tense / 'highly strung' 6.4 18 7 21.2 -0.97 5.1e-12 AC144652.1 ADCK3 ANKK1 CNNM2 DTD1 NINJ1 ORC4 PCCB PLGLB1 RANGAP1 RERE RP11-160H22.5 RP11-165J3.6 RPS6KL1 STX1B TMEM106B TP53INP2 U73166.2
Seen doctor (GP) for nerves, anxiety, tension or depression 5.6 7 2 6.1 -0.97 8.6e-05 ANKK1 FTSJ2 GPX1 RPS6KL1 TCF4 TMEM106B TMEM161B-AS1
Hair/balding pattern: Pattern 4 2.4 1 1 3.0 0.00 1.0e+00 RP11-259G18.1
Birth weight of first child 1.4 1 0 0.0 0.00 1.0e+00 PAFAH1B1
Peak expiratory flow (PEF) 1.6 2 1 3.0 0.00 1.0e+00 PPP6C RP11-259G18.1
Qualifications: O levels/GCSEs or equivalent 1.6 2 1 3.0 0.00 1.0e+00 GPX1 PLCL2
Medication: Paracetamol 2.6 4 2 6.1 -0.99 9.7e-03 GPX1 RP11-160H22.5 RP11-259G18.1 UBXN2A
Headache pain in last month 2.8 5 1 3.0 -0.99 6.5e-04 MPP6 NT5DC2 RP11-259G18.1 TLR4 ZDHHC5
Medication for cholesterol, blood pressure or diabetes 1.4 1 0 0.0 0.00 1.0e+00 TMEM161B-AS1
Hypothyroidism/myxoedema (self-reported) 1.2 1 0 0.0 0.00 1.0e+00 RERE
Birth weight 1.7 5 2 6.1 -0.17 7.8e-01 C1QTNF4 CNNM2 MTCH2 PTCH1 UBXN2A
Forced vital capacity (FVC), Best measure 2.5 10 7 21.2 0.09 7.9e-01 AC018641.7 C1QTNF4 GPX1 LRP4 MTCH2 PTCH1 RP11-259G18.1 SNAI3-AS1 STX1B UBXN2A
Body fat percentage 3.6 19 10 30.3 0.14 5.7e-01 ANKK1 ARNTL BEND4 C1QTNF4 FTSJ2 GALNT16 GPX1 LINC00461 MADD MAP2K5 MTCH2 RANGAP1 RERE RP11-259G18.1 RPS6KL1 SBF2 STK24 STX1B ZDHHC5
Leg fat percentage (right) 3.4 17 11 33.3 0.06 8.1e-01 AC018641.7 ANKK1 ARNTL C1QTNF4 FTSJ2 GALNT16 GPX1 LINC00461 MADD MAP2K5 MTCH2 RERE RP11-165J3.6 RPS6KL1 SBF2 STK24 STX1B
Arm fat-free mass (right) 1.4 10 6 18.2 0.26 4.7e-01 BRD3 CNNM2 GPX1 HAT1 LINC00461 PPP6C PTCH1 SBF2 TP53INP2 UBXN2A
Comparative body size at age 10 3.2 10 6 18.2 0.86 3.6e-04 C1QTNF4 LINC00461 MADD MAP2K5 MTCH2 NINJ1 RANGAP1 RP11-165J3.6 STX1B U73166.2
Number of full brothers 1.6 1 0 0.0 0.00 1.0e+00 RP11-259G18.1
Worry too long after embarrassment 6.2 12 4 12.1 -0.96 6.5e-07 ANKK1 ARNTL EIF4G3 LINC00461 MAP2K5 MMAB NCAM1 PCCB PPP6C RP11-259G18.1 TP53INP2 ZDHHC5
Seen a psychiatrist for nerves, anxiety, tension or depression 3.6 1 0 0.0 0.00 1.0e+00 TMEM106B
Wheeze or whistling in the chest in last year 2.0 5 0 0.0 -0.66 2.3e-01 GPX1 MVD RERE RP11-165J3.6 SNAI3-AS1
Age at first live birth 1.6 1 1 3.0 0.00 1.0e+00 GPX1
Qualifications: College or University degree 2.5 11 5 15.2 0.75 8.1e-03 CELF4 FTSJ2 GALNT16 GPX1 KIAA1328 LINC00461 NINJ1 RP11-160H22.5 RP11-259G18.1 STK24 ZDHHC5
Medication for pain relief, constipation, heartburn 2.5 5 2 6.1 0.97 1.4e-03 GPX1 RP11-160H22.5 RP11-165J3.6 RP11-259G18.1 RPS6KL1
Neck or shoulder pain in last month 2.2 1 0 0.0 0.00 1.0e+00 GPX1
Mean time to correctly identify matches 2.3 4 2 6.1 0.65 3.5e-01 ARHGAP1 HAT1 LRP4 TMEM161B-AS1
Whole body fat mass 2.7 16 8 24.2 0.27 2.9e-01 ANKK1 ARNTL C1QTNF4 CNNM2 FTSJ2 GALNT16 GPX1 HAT1 LINC00461 MADD MAP2K5 MTCH2 RERE RP11-259G18.1 STK24 STX1B
Leg fat mass (right) 2.7 15 10 30.3 0.15 5.9e-01 AC018641.7 ANKK1 ARNTL C1QTNF4 CNNM2 FTSJ2 GALNT16 GPX1 LINC00461 MADD MAP2K5 MTCH2 RERE STK24 STX1B
Arm predicted mass (right) 1.4 10 5 15.2 0.26 4.6e-01 BRD3 CNNM2 GPX1 HAT1 LINC00461 PPP6C PTCH1 SBF2 TP53INP2 UBXN2A
Pulse rate, automated reading 1.6 6 1 3.0 -0.76 8.1e-02 GAB2 LINC00461 RP11-160H22.5 SBF2 TMEM161B-AS1 ZDHHC5
Alcohol intake frequency. 3.0 8 5 15.2 0.03 9.4e-01 C1QTNF4 GALNT16 MADD MTCH2 RP11-259G18.1 TCF4 TMEM161B-AS1 ZDHHC5
Comparative height size at age 10 1.3 12 5 15.2 0.19 5.5e-01 C1QTNF4 GPX1 METTL13 MTCH2 NT5DC2 PCCB PTCH1 RP11-259G18.1 RPS6KL1 SNCA TCF4 UBXN2A
Suffer from 'nerves' 7.0 9 4 12.1 -0.95 3.7e-05 ANKK1 ARHGAP1 C1QTNF4 DTD1 EIF4G3 MADD MTCH2 RERE RPS6KL1
Overall health rating 3.2 6 2 6.1 -0.95 3.0e-03 ANKK1 GALNT16 GPX1 NCAM1 NINJ1 RP11-165J3.6
Chest pain or discomfort 2.1 1 0 0.0 0.00 1.0e+00 AC144652.1
Age at last live birth 1.6 2 1 3.0 0.00 1.0e+00 DTD1 GPX1
Leg pain on walking 1.4 1 0 0.0 0.00 1.0e+00 RP11-259G18.1
Knee pain experienced in last month 1.9 2 0 0.0 0.00 1.0e+00 RP11-160H22.5 TP53INP2
Hypertension (Self-reported) 1.9 8 1 3.0 -0.29 4.8e-01 ARHGAP1 ARNTL CNNM2 EIF4G3 LRP4 MADD MAP2K5 RERE
Forced expiratory volume in 1-second (FEV1), predicted 1.4 2 0 0.0 0.00 1.0e+00 C1QTNF4 PTCH1
Whole body fat-free mass 1.4 11 7 21.2 0.48 1.4e-01 ARHGAP1 BRD3 CNNM2 HAT1 LINC00461 PPP6C PTCH1 RPS6KL1 SBF2 TP53INP2 UBXN2A
Leg fat-free mass (right) 1.5 12 8 24.2 0.46 1.3e-01 BRD3 C1QTNF4 CNNM2 HAT1 LINC00461 MAP2K5 PPP6C PTCH1 SBF2 SNAI3-AS1 TP53INP2 UBXN2A
Arm fat percentage (left) 3.9 16 11 33.3 0.22 4.0e-01 AC018641.7 ANKK1 ARNTL C1QTNF4 CNNM2 FTSJ2 GPX1 LINC00461 MADD MAP2K5 MTCH2 RERE SBF2 STK24 STX1B ZDHHC5
Average weekly red wine intake 1.9 1 1 3.0 0.00 1.0e+00 ZDHHC5
Handedness (chirality/laterality): Left-handed 1.6 1 1 3.0 0.00 1.0e+00 RP11-259G18.1
Mood swings 8.3 24 13 39.4 -0.99 3.7e-19 ANKK1 C1QTNF4 GALNT16 GPX1 MADD MAP1LC3B METTL13 MTCH2 MVD NCAM1 NINJ1 PLCL2 RANGAP1 RP11-160H22.5 RP11-165J3.6 RP11-259G18.1 RPS6KL1 SNAI3-AS1 SNCA STK24 STX1B TCF4 TLR4 TMEM106B
Loneliness, isolation 6.3 10 4 12.1 -0.96 2.5e-06 BRD3 C1QTNF4 GPX1 MADD MTCH2 ORC4 RERE RP11-259G18.1 SUDS3 TMEM106B
Long-standing illness, disability or infirmity 2.1 1 0 0.0 0.00 1.0e+00 TMEM161B-AS1
Qualifications: nursing, teaching 2.1 3 0 0.0 0.00 1.0e+00 GALNT16 RNPEP STK24
Mouth/teeth dental problems: Mouth ulcers 1.2 1 1 3.0 0.00 1.0e+00 RP11-259G18.1
Medication for cholesterol 1.4 1 0 0.0 0.00 1.0e+00 STX1B
Mineral and other dietary supplements 1.1 1 0 0.0 0.00 1.0e+00 BEND4
Asthma (self-reported) 1.4 2 1 3.0 0.00 1.0e+00 MVD RERE
Smoking status: Current 2.3 5 0 0.0 -0.59 2.2e-01 C1QTNF4 MTCH2 PPP6C RANGAP1 UBXN2A
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.6 3 2 6.1 0.00 1.0e+00 IGSF9B RP11-259G18.1 STX1B
Whole body water mass 1.4 12 7 21.2 0.42 1.7e-01 ARHGAP1 BRD3 CNNM2 GPX1 HAT1 LINC00461 PPP6C PTCH1 RPS6KL1 SBF2 TP53INP2 UBXN2A
Leg predicted mass (right) 1.5 12 7 21.2 0.46 1.3e-01 BRD3 C1QTNF4 CNNM2 HAT1 LINC00461 MAP2K5 PPP6C PTCH1 SBF2 SNAI3-AS1 TP53INP2 UBXN2A
Arm fat mass (left) 2.8 14 8 24.2 0.26 3.5e-01 AC018641.7 ANKK1 ARNTL C1QTNF4 CNNM2 FTSJ2 GPX1 LINC00461 MADD MAP2K5 MTCH2 RERE STK24 STX1B
Number of self-reported non-cancer illnesses 2.9 5 1 3.0 -0.46 4.3e-01 ARNTL EIF4G3 FTSJ2 LRP4 TMEM106B
Average weekly champagne plus white wine intake 1.7 1 0 0.0 0.00 1.0e+00 RP11-259G18.1
Miserableness 8.2 22 14 42.4 -0.97 1.7e-15 ANKK1 ARHGAP1 ARNTL C1QTNF4 FTSJ2 GPX1 LINGO1 LRP4 MADD METTL13 MMAB MTCH2 NCAM1 ORC4 PAFAH1B1 RP11-160H22.5 RP11-165J3.6 RP11-259G18.1 SNAI3-AS1 TCF4 TMEM106B UBXN2A
Guilty feelings 6.8 13 6 18.2 -0.97 9.2e-08 ANKK1 ARNTL C1QTNF4 LINGO1 MADD METTL13 NCAM1 PAFAH1B1 PTCH1 RP11-259G18.1 RPS6KL1 UBXN2A ZDHHC5
Financial situation satisfaction 2.3 2 1 3.0 0.00 1.0e+00 BRD3 GPX1
Medication: Blood pressure 1.4 2 1 3.0 0.00 1.0e+00 CNNM2 RP11-259G18.1
Medication: Bendroflumethiazide 1.6 1 0 0.0 0.00 1.0e+00 SNAI3-AS1
Medication: Paracetamol 2.4 4 2 6.1 -0.99 1.1e-02 GPX1 RP11-160H22.5 RP11-259G18.1 UBXN2A
Illnesses of father: High blood pressure 1.5 1 0 0.0 0.00 1.0e+00 MADD
Alcohol drinker status: Never 1.7 1 0 0.0 0.00 1.0e+00 C1QTNF4
Ever smoked 2.2 2 1 3.0 -0.97 3.1e-02 PPP6C TMEM161B-AS1
Basal metabolic rate 1.3 11 7 21.2 0.29 4.0e-01 BRD3 CNNM2 GPX1 HAT1 LINC00461 MAP2K5 PPP6C PTCH1 SBF2 TP53INP2 UBXN2A
Leg fat percentage (left) 3.5 16 10 30.3 0.11 6.7e-01 AC018641.7 ANKK1 ARNTL C1QTNF4 GALNT16 GPX1 LINC00461 MADD MAP2K5 MTCH2 RERE RP11-165J3.6 RPS6KL1 SBF2 STK24 STX1B
Arm fat-free mass (left) 1.3 9 5 15.2 0.23 5.5e-01 BRD3 CNNM2 GPX1 LINC00461 PPP6C PTCH1 SBF2 TP53INP2 UBXN2A
Number of operations (self-reported) 1.9 1 0 0.0 0.00 1.0e+00 GPX1
Irritability 5.7 16 6 18.2 -0.97 1.1e-09 ANKK1 FTSJ2 GPX1 LINC00461 MMAB MVD ORC4 PAFAH1B1 RANGAP1 RP11-259G18.1 SNAI3-AS1 STX1B TCF4 TLR4 TMEM106B TP53INP2
Risk taking 1.2 1 0 0.0 0.00 1.0e+00 PCCB
Ever had prostate specific antigen (PSA) test 1.6 1 0 0.0 0.00 1.0e+00 PAFAH1B1
Diastolic blood pressure, automated reading 1.9 8 4 12.1 -0.38 3.6e-01 ARNTL CNNM2 GPX1 LINC00461 MADD PAFAH1B1 RERE SBF2
Myopia 1.7 2 0 0.0 0.00 1.0e+00 FTSJ2 MTCH2
Vascular/heart problems diagnosed by doctor 2.0 8 3 9.1 0.27 5.2e-01 ARHGAP1 ARNTL CNNM2 EIF4G3 LRP4 MADD MAP2K5 RERE
Cholesterol lowering medication 1.2 1 0 0.0 0.00 1.0e+00 STX1B
Pain experienced in last month 2.9 4 1 3.0 0.64 3.6e-01 GPX1 MMAB RP11-160H22.5 STX1B
Basal cell carcinoma (self-reported) 1.4 1 1 3.0 0.00 1.0e+00 TP53INP2
Heart attack/myocardial infarction (self-reported) 1.7 1 0 0.0 0.00 1.0e+00 TMEM161B-AS1
Pack years of smoking 1.5 1 0 0.0 0.00 1.0e+00 GPX1
Impedance of whole body 1.9 14 12 36.4 -0.12 6.7e-01 ADCK3 BEND4 CNNM2 GAB2 GPX1 LINC00461 NT5DC2 PPP6C RANGAP1 RP11-259G18.1 SBF2 TP53INP2 U73166.2 UBXN2A
Leg fat mass (left) 2.8 16 8 24.2 0.17 5.1e-01 AC018641.7 ANKK1 ARNTL C1QTNF4 CNNM2 FTSJ2 GALNT16 GPX1 HAT1 LINC00461 MADD MAP2K5 MTCH2 RERE STK24 STX1B
Arm predicted mass (left) 1.3 9 6 18.2 0.22 5.7e-01 BRD3 CNNM2 GPX1 LINC00461 PPP6C PTCH1 SBF2 TP53INP2 UBXN2A

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 18 0.515 2.31
GTEx Adipose Visceral Omentum 13 0.638 2.57
GTEx Adrenal Gland 11 0.755 2.50
GTEx Artery Aorta 17 0.571 2.49
GTEx Artery Coronary 16 1.351 3.03
GTEx Artery Tibial 18 0.479 2.36
GTEx Brain Caudate basal ganglia 10 1.087 2.82
GTEx Brain Cerebellar Hemisphere 11 0.739 2.64
GTEx Brain Cerebellum 14 0.706 2.53
GTEx Brain Cortex 13 1.257 2.99
GTEx Brain Frontal Cortex BA9 8 0.865 2.83
GTEx Brain Hippocampus 6 1.143 3.15
GTEx Brain Hypothalamus 5 0.846 2.83
GTEx Brain Nucleus accumbens basal ganglia 9 1.039 2.85
GTEx Brain Putamen basal ganglia 6 0.962 2.92
GTEx Breast Mammary Tissue 18 0.911 2.57
GTEx Breast Mammary Tissue (Male) 10 0.838 2.65
GTEx Breast Mammary Tissue (Female) 17 1.033 2.63
GTEx Cells EBV-transformed lymphocytes 12 0.844 2.87
GTEx Cells Transformed fibroblasts 19 0.453 2.42
GTEx Colon Sigmoid 11 0.752 2.63
GTEx Colon Transverse 19 0.920 2.62
GTEx Esophagus Gastroesophageal Junction 15 1.038 2.87
GTEx Esophagus Mucosa 22 0.662 2.45
GTEx Esophagus Muscularis 21 0.650 2.66
GTEx Heart Atrial Appendage 15 0.949 2.69
GTEx Heart Left Ventricle 12 0.784 2.68
GTEx Liver 8 1.116 2.82
GTEx Lung 16 0.557 2.51
GTEx Muscle Skeletal 17 0.588 2.50
GTEx Nerve Tibial 21 0.486 2.35
GTEx Ovary 12 1.320 3.07
GTEx Pancreas 13 0.796 2.62
GTEx Pituitary 12 1.075 2.63
GTEx Prostate 10 1.199 2.80
GTEx Skin Not Sun Exposed Suprapubic 20 0.813 2.69
GTEx Skin Sun Exposed Lower leg 24 0.660 2.60
GTEx Small Intestine Terminal Ileum 5 1.082 3.01
GTEx Spleen 13 0.921 2.78
GTEx Stomach 12 0.825 2.75
GTEx Testis 27 0.855 2.59
GTEx Thyroid 21 0.525 2.44
GTEx Uterus 9 1.587 3.25
GTEx Vagina 5 0.787 2.90
GTEx Whole Blood 13 0.653 2.50
METSIM Adipose 16 0.347 2.16
NTR Blood 9 0.375 2.25
ROSMAP Brain Pre-frontal Cortex 21 0.478 2.32
YFS Blood 14 0.303 2.09
CommonMind Brain Pre-frontal Cortex 14 0.260 2.20
TCGA Breast Tumor 6 0.783 2.34
TCGA Breast Normal 13 0.309 2.01
TCGA Ovarian Tumor 11 0.376 2.11
TCGA Prostate Tumor 10 0.289 2.22