Hub : Genes

STK24

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0770 0.0260 1.5e-03 0.026 0.024 0.025 0.025 0.031 3.5e-04 5.8e-04 4.1e-04 4.1e-04 9.0e-05
2 GTEx Adipose Subcutaneous 0.1790 0.0410 1.2e-06 0.063 NA 0.083 NA 0.084 7.5e-06 NA 2.7e-07 NA 2.4e-07
3 GTEx Artery Tibial 0.1203 0.0398 1.3e-03 0.097 NA 0.075 NA 0.079 4.8e-08 NA 1.7e-06 NA 8.4e-07
4 NTR Blood 0.0634 0.0148 4.0e-09 0.018 0.032 0.026 0.031 0.029 1.4e-06 1.2e-10 4.7e-09 2.0e-10 7.5e-10
5 TCGA Kidney Renal Clear Cell Carcinoma 0.0402 0.0173 4.9e-04 0.033 0.030 0.035 NA 0.036 1.2e-04 2.0e-04 6.7e-05 NA 5.3e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.8 2.9 10.1 -3.2 -0.3 1.1 0.9 1.5
Bipolar Disorder or Schizophrenia 0.9 2.1 4.5 -2.1 1.2 1.5 1.3 0.9
Depressed Affect (Nagel 2018) 3.8 7.9 14.8 -0.0 -3.5 -2.4 -2.5 3.8
Depression (Nagel 2018) 4.5 6.8 13.9 -0.5 -3.2 -2.1 -2.4 3.7
Intelligence (Savage-Jansen 2018) 1.2 3.6 7.8 1.0 2.8 1.3 1.6 -2.2
Neuroticism (Nagel 2018) 4.3 10.1 20.0 0.7 -4.5 -2.9 -2.9 3.6
Schizophrenia (2018) 0.5 1.0 2.9 -0.2 1.7 1.0 0.9 -0.3
Schizophrenia vs Biploar Disorder 1.2 1.6 4.8 2.2 -0.3 -0.8 -0.7 -1.4
Worry (Nagel 2018) 5.0 10.5 24.9 0.6 -5.0 -2.9 -3.1 3.1
Alzheimer’s Disease (in mother) 1.2 1.4 3.8 -1.4 1.9 1.0 0.3 0.3
Alzheimer’s Disease (in father) 2.0 2.2 5.5 2.4 0.6 -1.4 -0.9 -1.5
Alzheimer’s Disease (including proxy) 1.0 1.4 5.5 0.7 2.4 0.1 -0.0 -1.0
Crohns Disease (2017) 1.9 4.1 7.5 -1.0 -2.6 -1.9 -1.2 2.7
Irritable Bowel Disease (IBD) 1.6 3.8 8.7 -0.9 -2.7 -1.5 -0.5 3.0
Ulcerative Colitis (UC) 0.7 1.3 3.6 -0.5 -1.5 0.0 0.6 1.9
Major Depression (MDD) 0.4 0.5 1.0 -0.8 -0.4 0.2 -1.0 0.8
Reaction Time 1.7 3.2 5.0 1.7 -2.2 -2.1 -1.6 1.1
Verbal and Numeric Reasoning (VNR) 1.4 3.4 5.8 1.8 2.4 1.1 1.5 -2.1
Breast Cancer 2.5 6.0 13.8 1.0 -2.5 -3.7 -2.6 1.5
Ovarian Cancer 0.6 0.7 1.4 -0.8 0.5 0.1 -1.2 1.2
Prostate Cancer 1.2 1.7 3.0 1.7 -0.3 -1.2 -1.5 -1.3
Age at First Birth 3.4 5.0 10.1 -0.3 3.2 1.3 2.1 -2.9
Bipolar Disorder (2011) 0.6 0.6 1.8 -0.6 0.5 1.4 0.4 -0.5
Body Mass Index (BMI) (2010) 1.3 1.8 3.1 -1.6 -1.5 -0.8 -0.3 1.8
Coronary Artery Disease (CAD) 1.0 1.2 2.8 1.3 0.5 1.2 -0.1 -1.7
Crohns Disease (2012) 1.2 1.9 4.5 -0.2 -2.0 -0.8 -0.6 2.1
Mean Putamen Volume 4.0 4.6 10.7 -1.3 3.3 2.5 2.0 -0.5
Fasting Glucose 0.3 0.4 1.1 0.4 -0.1 -0.6 -1.0 0.5
HbA1C 1.6 1.8 3.7 -0.8 -1.0 -1.9 -1.4 1.3
HDL Cholesterol 0.5 0.8 2.6 -0.9 0.8 -0.0 1.6 -0.5
LDL Cholesterol 0.3 0.4 1.7 -1.3 0.1 0.4 0.5 0.2
Lupus 0.8 1.1 3.7 -1.2 -0.5 -0.6 -0.2 1.9
Neuroticism (2016) 6.8 9.8 18.5 1.8 -4.3 -3.3 -3.3 2.3
Primary Biliary Cirrhosis 0.6 0.9 2.2 -0.9 -0.4 0.9 1.5 0.7
Rheumatoid Arthritis 0.8 1.0 2.7 0.2 0.4 1.6 1.2 -0.9
Schizophrenia (2014) 0.4 1.0 1.7 -0.6 1.2 1.1 1.3 -0.0
Triglycerides 0.9 1.4 2.9 1.1 -0.9 -1.4 -1.7 0.4
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.9 0.3 -0.8 0.0 -1.4 0.4
Ulcerative Colitis 0.7 1.1 3.0 -0.4 -0.0 0.8 1.7 1.2
Blood Eosinophil Count 0.6 4.7 8.2 2.6 -0.8 -2.0 -2.9 -2.0
Blood Platelet Count 0.0 0.5 1.7 -0.4 0.5 0.1 0.6 -1.3
Blood Red Count 0.2 2.0 3.6 -1.9 -1.4 -1.4 -0.6 1.4
Blood White Count 0.3 2.0 2.6 -0.7 -1.6 -1.5 -1.6 1.4
Heel T-Score 0.3 2.3 5.1 0.9 1.1 2.1 0.2 -2.2
BMI 3.7 21.5 31.6 -2.1 -5.6 -4.9 -4.1 5.5
Height 0.7 13.4 20.5 -0.7 3.9 4.5 3.5 -4.3
Waist Hip Ratio (WHR) 0.4 1.9 5.0 0.1 -1.4 -0.6 -2.2 1.4
Systolic Blood Pressure 0.3 1.6 5.5 1.3 -2.3 -0.3 -0.8 -0.5
Smoking Status 0.4 0.9 2.1 1.3 -0.8 -0.1 -1.4 -0.2
Allergy or Eczema 0.8 2.0 5.2 -2.3 -0.1 -0.4 -0.1 2.2
Cardiovascular Disease 1.4 4.8 8.0 0.9 -2.6 -2.5 -2.8 1.4
Hypothyroidism (self reported) 0.4 0.9 2.3 1.5 -0.1 -0.0 0.6 -1.4
Respiratory disease 0.2 0.4 1.7 -1.3 -0.2 0.1 0.2 0.1
Type 2 Diabetes (T2D) (2018) 1.5 2.9 4.9 0.3 -2.2 -2.0 -1.7 1.6
Lung FEV1/FVC ratio 0.4 2.3 4.2 0.9 -1.6 -0.8 -1.8 2.0
Lung FVC 1.0 5.3 10.3 -0.8 2.8 3.2 1.8 -2.1
Neuroticism 6.8 16.3 29.6 0.3 -5.4 -3.3 -4.3 4.7
Chronotype (morning person) 0.4 0.9 2.9 -0.5 0.1 1.1 1.7 -0.4
Hair Pigment 0.0 0.8 2.6 -0.0 -1.2 -1.6 0.2 -0.2
Tanning 0.1 0.8 2.0 0.4 1.4 1.0 -0.6 -0.5
Hand grip strength (left) 2.0 5.3 11.1 -1.8 3.3 2.2 1.2 -2.4
Number of treatments/medications taken 2.5 4.5 6.3 1.7 -2.2 -2.5 -2.4 1.5
Average weekly spirits intake 0.7 0.9 1.9 -1.4 -1.0 -0.6 -0.3 1.0
Sensitivity / hurt feelings 0.6 1.1 2.4 0.4 -1.6 -0.7 -1.2 0.9
Frequency of depressed mood in last 2 weeks 6.2 8.6 16.5 -0.7 -4.1 -1.8 -2.8 3.9
Hearing difficulty/problems: Yes 2.5 3.8 13.5 0.1 3.7 1.8 1.3 -0.7
Relative age of first facial hair 0.1 0.3 0.6 0.4 0.0 -0.3 -0.7 -0.8
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 1.3 -0.1 1.0 -0.3 -1.1 0.9
Ever used hormone-replacement therapy (HRT) 0.7 0.9 1.8 1.0 -1.3 -0.2 -1.1 0.4
Ever had hysterectomy (womb removed) 1.0 1.1 4.7 -0.8 0.1 0.5 0.4 2.2
Systolic blood pressure, automated reading 1.0 2.9 9.7 0.5 -3.1 -0.8 -2.0 0.2
Eye problems/disorders: Diabetes related eye disease 2.5 2.8 6.7 0.2 -2.6 -2.2 -1.0 1.2
Angina 1.2 1.6 3.5 0.9 -1.1 -1.9 -1.4 0.6
Medication for hormone replacement therapy 0.4 0.5 1.3 0.5 -0.3 -0.0 -1.1 0.8
Vitamin and mineral supplements 0.7 0.9 2.5 -0.7 1.6 0.3 1.3 -0.3
Supplements: Zinc 0.3 0.3 0.9 -1.0 0.2 0.8 0.3 -0.1
Medication: Co-codamol 3.7 4.3 9.1 1.5 -3.0 -2.7 -1.7 0.1
Medication: Metformin 0.3 0.4 1.4 -0.0 -0.8 0.3 -0.4 1.2
Diabetes (father) 0.1 0.2 0.4 -0.4 -0.6 -0.1 0.2 0.5
Diabetes (mother) 3.3 4.2 6.9 -1.4 -2.3 -2.2 -1.5 2.6
Severe depression (siblings) 1.1 1.2 3.1 -0.2 -1.4 -0.8 -1.8 0.7
Pack years adult smoking proportion 1.8 2.8 6.2 0.7 -2.0 -2.5 -1.2 1.4
Impedance of leg (right) 0.1 0.7 1.1 1.0 -0.1 -1.0 -0.9 -0.9
Leg fat-free mass (left) 0.3 1.7 4.3 -2.1 -1.3 -0.3 0.1 1.5
Trunk fat percentage 5.4 21.7 36.4 -0.7 -5.8 -6.0 -4.2 4.5
Hand grip strength (right) 1.1 3.1 6.9 -2.6 2.3 1.0 1.4 -0.6
Townsend deprivation index at recruitment 2.9 4.1 8.7 0.2 -2.7 -2.9 -2.1 0.5
Current tobacco smoking 1.4 2.3 4.5 2.1 -0.6 -1.4 -2.1 -0.1
Average weekly fortified wine intake 2.7 3.1 7.4 -0.6 2.2 2.7 1.6 -0.8
Maternal smoking around birth 1.9 2.8 5.5 1.7 -1.2 -1.7 -2.3 1.1
Fed-up feelings 2.7 4.8 8.9 0.0 -3.0 -1.9 -1.9 2.8
Frequency of unenthusiasm / disinterest in last 2 weeks 4.2 5.6 10.4 -0.7 -2.9 -2.1 -2.1 3.2
Relative age voice broke 1.5 2.3 4.2 0.4 1.9 0.9 1.6 -2.0
Taking other prescription medications 1.6 2.4 4.0 1.1 -1.7 -2.0 -1.7 1.1
Age when periods started (menarche) 0.4 0.9 1.6 -0.5 0.3 1.2 1.1 -1.3
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 1.0 -0.1 0.5 0.6 1.0 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.5 3.8 1.5 -0.9 0.6 -0.2 -2.0
Tinnitus: Yes, but not now, but have in the past 1.4 1.5 3.4 0.3 -1.8 -1.1 -0.6 1.6
Qualifications: CSEs or equivalent 1.9 2.5 4.5 -0.5 -2.1 -1.8 -1.0 1.9
Serious illness, injury or assault to yourself 0.4 0.5 1.7 -0.5 1.3 -0.7 -0.2 0.3
High blood pressure 2.1 5.8 8.5 2.6 -2.7 -2.4 -2.9 0.5
Hayfever, allergic rhinitis or eczema 0.3 0.7 2.0 -0.9 0.7 -0.5 -0.3 1.4
Multivitamins +/- minerals 0.3 0.4 0.8 0.8 -0.9 0.2 -0.6 -0.2
Stomach or abdominal pain in last month 2.2 2.7 7.5 -1.3 -1.8 -0.9 -0.6 2.7
Supplements: Glucosamine 0.5 0.7 1.9 0.3 -1.4 -0.1 -0.9 0.9
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.7 -0.9 -0.5 -0.3 -0.5 1.3
Medication: Atenolol 0.7 0.8 2.1 0.2 -0.6 -1.4 -0.6 1.1
Medication: Levothyroxine sodium 0.9 1.5 3.0 0.1 1.1 1.3 1.7 -1.2
Sitting height 0.7 4.7 8.4 -2.9 1.7 2.6 2.1 -0.9
Chronic bronchitis/emphysema (father) 0.2 0.2 0.7 -0.3 -0.5 -0.0 0.2 0.9
High blood pressure (mother) 0.2 0.3 0.7 0.9 -0.7 -0.3 -0.2 -0.3
Body mass index (BMI) 3.6 15.4 22.9 -0.7 -4.8 -4.8 -3.5 4.3
Impedance of leg (left) 0.1 0.4 0.6 0.5 -0.2 -0.8 -0.7 -0.7
Leg predicted mass (left) 0.3 1.8 4.4 -2.1 -1.4 -0.3 0.1 1.6
Trunk fat mass 3.8 16.3 25.9 -0.9 -5.1 -5.1 -3.5 4.1
Waist circumference 3.6 13.3 22.8 -0.6 -4.8 -4.1 -3.6 3.6
Number of incorrect matches in round 2.1 3.4 6.8 1.5 -2.3 -1.6 -2.6 0.2
Past tobacco smoking 0.3 0.6 1.5 0.4 -0.9 -1.2 -0.1 0.6
Alcohol usually taken with meals 3.3 5.4 9.7 -1.3 2.7 3.1 2.3 -1.8
Nervous feelings 5.7 10.7 20.2 1.3 -4.5 -3.2 -3.2 3.4
Frequency of tenseness / restlessness in last 2 weeks 4.9 7.7 15.0 0.1 -3.9 -1.9 -2.7 3.5
Hearing difficulty/problems with background noise 0.7 1.1 2.7 0.5 1.6 1.5 0.3 0.3
Hair/balding pattern: Pattern 2 0.4 0.5 2.1 -0.0 0.6 -0.0 -0.3 -1.4
Had menopause 0.5 0.6 2.2 1.5 0.2 -0.5 -0.2 -0.6
Had other major operations 0.6 0.8 2.8 -0.3 0.4 0.7 1.7 -0.6
Forced vital capacity (FVC) 2.9 11.0 22.3 -2.6 3.1 4.7 3.3 -2.3
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.7 4.5 1.6 -1.1 0.1 -0.3 -2.1
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.6 -0.4 1.3 0.2 -0.4 -0.7
Qualifications: None of the above 3.9 8.3 12.8 0.9 -3.6 -3.0 -3.6 2.5
Financial difficulties in last 2 years 1.9 2.5 4.1 0.2 -2.0 -2.0 -1.4 1.5
Mouth/teeth dental problems 0.4 0.7 3.1 0.4 -1.8 -0.2 -0.0 -0.1
Heart attack 0.1 0.1 0.4 0.6 0.2 0.0 -0.3 0.0
Allergy 0.1 0.3 0.5 0.5 -0.4 0.6 0.7 -0.6
Pain all over the body in last month 4.0 4.3 9.2 0.9 -2.9 -3.0 -1.5 0.8
Diabetes (self-reported) 0.9 1.4 2.9 0.5 -1.6 -0.9 -0.9 1.7
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 1.5 0.5 -0.2 -1.1 -1.2 0.7
Medication: Ramipril 1.5 1.9 4.9 2.2 -0.5 -1.8 -0.5 -0.9
Medication: Simvastatin 0.8 1.1 2.1 1.0 -0.9 -1.0 -1.5 0.8
Fluid intelligence score 1.1 2.3 5.1 1.6 2.3 1.2 0.7 -1.4
Illnesses of siblings 1.8 2.5 6.0 -0.5 2.4 0.7 1.7 -1.8
Neuroticism score 6.2 12.9 24.8 0.5 -5.0 -2.7 -3.8 4.2
Weight 1.4 6.7 10.9 -1.8 -3.3 -2.7 -1.7 3.0
Impedance of arm (right) 0.1 0.3 0.7 -0.8 -0.5 -0.1 0.3 0.7
Arm fat percentage (right) 6.0 23.6 36.6 -0.9 -5.9 -6.0 -4.2 5.3
Trunk fat-free mass 0.5 2.7 4.9 -2.2 1.1 2.1 1.6 -0.2
Hip circumference 1.7 7.2 11.6 -1.6 -3.4 -3.3 -1.9 2.8
Time employed in main current job 1.0 1.1 2.7 -1.2 -0.8 -0.5 0.6 1.7
Alcohol intake versus 10 years previously 2.3 3.5 8.4 0.2 -2.3 -1.9 -0.0 2.9
Father’s age at death 0.9 1.2 1.7 1.1 0.4 1.2 1.3 -1.3
Worrier / anxious feelings 3.6 6.8 13.1 -0.0 -3.6 -2.4 -2.5 3.0
Frequency of tiredness / lethargy in last 2 weeks 3.6 5.9 15.3 -0.6 -2.8 -2.3 -0.7 3.9
Falls in the last year 0.5 0.7 2.0 0.7 -0.1 0.8 0.2 -1.4
Hair/balding pattern: Pattern 3 0.1 0.2 0.4 -0.5 -0.6 -0.2 0.2 0.3
Number of live births 0.5 0.8 1.8 0.8 0.3 -1.3 -0.2 -1.1
Forced expiratory volume in 1-second (FEV1) 2.6 8.9 18.6 -2.0 3.0 4.3 3.0 -1.9
Pulse rate 1.3 2.1 6.9 -2.6 0.0 0.3 -0.1 1.9
Happiness 1.3 1.6 3.4 1.8 0.2 -0.9 -1.7 -0.9
Noisy workplace 1.4 1.7 4.1 0.3 -1.6 -2.0 -0.5 1.2
Qualifications: A levels/AS levels or equivalent 2.7 6.1 14.7 0.7 3.8 2.7 2.0 -2.1
Serious illness, injury or assault of a close relative in last 2 years 0.8 1.0 2.8 0.6 -1.7 -0.1 -0.3 1.3
Mouth/teeth dental problems: Dentures 0.6 1.0 1.7 -0.6 -0.2 -1.2 -1.2 1.3
Asthma 0.2 0.4 0.8 -0.9 0.2 0.0 -0.7 0.7
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.7 0.0 -0.8 -0.8 -0.3 0.3
Medication: Cholesterol lowering 2.3 3.5 6.3 1.5 -2.0 -2.5 -2.1 0.9
Depression (self-reported) 2.0 2.4 4.6 -0.6 -1.7 -1.5 -1.4 2.1
Medication: Lansoprazole 0.9 1.0 2.0 -0.1 -1.4 -0.9 -0.9 1.1
Prospective memory result 0.2 0.2 0.5 0.7 0.2 0.6 -0.3 0.1
Lung cancer (father) 1.2 1.5 3.0 1.4 1.5 0.3 0.1 -1.7
Illnesses of mother 0.5 0.6 1.3 0.4 0.4 1.1 1.1 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 2.7 8.7 16.6 -1.5 3.2 4.1 2.6 -2.7
Pulse wave Arterial Stiffness index 1.4 1.6 3.0 0.8 -1.7 -1.7 -1.0 0.7
Impedance of arm (left) 0.0 0.0 0.1 0.0 -0.1 -0.3 0.1 -0.1
Arm fat mass (right) 3.7 15.3 24.8 -1.3 -5.0 -4.7 -3.1 4.3
Trunk predicted mass 0.4 2.5 4.6 -2.1 1.1 2.0 1.6 -0.2
Standing height 1.0 10.4 18.4 -2.8 2.8 4.3 3.6 -2.1
Length of working week for main job 0.4 0.5 1.7 -0.5 -0.4 -0.1 1.3 -0.3
Exposure to tobacco smoke at home 0.3 0.4 1.1 -0.7 -0.1 0.0 -0.4 1.1
Breastfed as a baby 2.3 2.9 4.2 -1.4 2.0 1.9 2.0 -0.7
Tense / ‘highly strung’ 4.1 6.9 15.1 0.9 -3.9 -2.1 -2.2 3.0
Seen doctor (GP) for nerves, anxiety, tension or depression 3.6 5.5 10.9 -0.6 -3.0 -1.8 -2.0 3.3
Hair/balding pattern: Pattern 4 0.7 1.8 4.0 1.2 -2.0 -1.5 -1.1 0.2
Birth weight of first child 0.4 0.7 1.9 -0.5 0.6 0.8 1.4 -0.4
Peak expiratory flow (PEF) 0.6 1.3 2.7 -1.7 0.8 1.7 0.3 0.6
Pulse wave reflection index 1.2 1.4 2.2 1.1 -1.5 -1.5 -1.2 0.4
Ever highly irritable/argumentative for 2 days 0.1 0.2 0.4 0.3 0.6 -0.0 -0.5 0.3
Loud music exposure frequency 2.6 2.9 4.6 -1.2 -1.8 -1.2 -1.9 2.1
Qualifications: O levels/GCSEs or equivalent 1.0 1.6 3.2 0.0 1.3 1.8 1.5 -0.8
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 4.2 -2.1 0.6 0.5 1.2 0.3
Blood clot in the leg (DVT) 0.2 0.3 0.6 0.5 -0.8 -0.6 0.2 -0.4
Medication: Paracetamol 0.6 0.9 2.3 1.5 0.9 -0.3 0.1 -1.2
Headache pain in last month 0.5 0.8 1.9 1.4 0.4 1.1 0.7 -0.4
Medication for cholesterol, blood pressure or diabetes 2.8 4.6 7.0 -1.9 2.3 2.7 2.5 -1.0
Glaucoma (self-reported) 0.7 0.8 2.1 1.0 0.5 -0.3 -0.8 -1.4
Gout (self-reported) 0.2 0.2 0.3 -0.6 -0.5 0.5 0.4 -0.3
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.8 0.9 -0.2 0.0 0.5 -0.9
Medication: Amlodipine 1.6 2.2 4.8 2.2 -0.5 -1.5 -1.9 -0.3
Medication: Ventolin 100micrograms inhaler 0.5 0.6 2.2 0.5 0.5 0.6 -0.3 -1.5
Birth weight 0.5 1.1 2.9 -1.1 0.6 0.8 1.7 -0.8
Chronic bronchitis/emphysema (mother) 1.7 2.0 6.3 0.7 -1.0 -2.5 -1.3 0.4
High blood pressure (siblings) 0.4 0.6 1.2 -0.1 -1.1 0.5 -1.0 0.9
Forced vital capacity (FVC), Best measure 3.4 12.5 22.3 -1.4 3.7 4.7 3.3 -3.7
Body fat percentage 6.2 24.6 43.1 -0.2 -6.0 -6.6 -4.6 4.7
Leg fat percentage (right) 7.1 25.7 45.8 0.9 -6.0 -6.8 -5.0 4.6
Arm fat-free mass (right) 0.1 0.6 2.1 -1.5 0.2 0.7 0.6 -0.2
Exposure to tobacco smoke outside home 0.5 0.6 0.8 0.9 -0.9 -0.7 -0.8 0.6
Comparative body size at age 10 0.7 2.0 8.0 -2.8 0.1 0.2 1.1 0.9
Number of full brothers 0.1 0.1 0.3 0.3 -0.2 0.0 -0.5 0.3
Worry too long after embarrassment 2.1 3.5 10.7 0.9 -3.3 -1.7 -1.4 1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.6 2.1 4.9 -0.8 -1.9 -0.8 -0.9 2.2
Wheeze or whistling in the chest in last year 5.9 10.5 20.7 1.6 -3.0 -4.5 -4.0 2.1
Number of children fathered 1.4 1.5 3.6 -1.9 1.2 1.0 1.3 0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.9 2.0 1.4 -0.1 -0.6 -1.3 0.5
Age at first live birth 1.9 3.3 6.4 2.5 2.1 0.7 0.2 -2.3
Pulse wave peak to peak time 1.8 2.1 4.1 -0.8 2.0 1.9 1.1 -0.9
Health satisfaction 1.2 1.5 3.6 1.8 0.2 -0.9 -1.9 0.2
Shortness of breath walking on level ground 1.2 1.5 4.6 2.1 -0.7 -0.8 -0.7 -1.1
Qualifications: College or University degree 6.2 19.4 38.5 0.6 6.2 4.9 3.3 -4.8
Eye problems/disorders: None of the above 0.9 1.1 3.6 1.9 -1.0 -0.8 -0.3 0.1
Mouth/teeth dental problems: Loose teeth 0.5 0.6 2.0 1.4 0.6 -0.8 -0.4 0.1
Emphysema/chronic bronchitis 0.3 0.3 0.5 -0.4 -0.5 0.7 -0.0 -0.7
Medication for pain relief, constipation, heartburn 0.8 1.4 3.5 -1.9 0.6 1.4 1.0 0.1
Neck or shoulder pain in last month 1.3 1.8 3.0 0.6 -1.7 -0.4 -1.6 1.7
Medication: Blood pressure 3.4 6.1 10.2 2.9 -2.0 -3.2 -2.6 0.9
Angina (self-reported) 0.7 1.0 2.6 0.6 -0.7 -1.6 -1.0 0.5
Migraine (self-reported) 2.5 3.1 7.7 2.8 -0.9 -1.7 -1.4 -1.4
Medication: Ibuprofen 0.2 0.3 0.5 0.3 -0.7 -0.5 0.3 0.7
Medication: Allopurinol 0.2 0.2 0.5 -0.1 0.5 0.7 0.4 -0.5
Medication: Omeprazole 0.8 0.9 1.6 -1.0 -1.3 -0.7 -0.5 1.1
Medication: Seretide 50 evohaler 1.4 1.6 2.9 0.5 -1.4 -1.7 -1.5 0.9
Mean time to correctly identify matches 1.8 3.4 5.6 1.6 -2.0 -2.4 -1.8 1.4
Heart disease (mother) 0.6 0.7 2.5 0.8 0.3 0.6 -1.6 -0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 5.1 6.1 8.6 -0.3 -2.6 -2.9 -2.7 2.8
Whole body fat mass 4.2 17.5 28.3 -0.6 -5.3 -5.3 -3.7 4.1
Leg fat mass (right) 4.4 17.1 27.4 -0.3 -5.2 -5.2 -3.8 4.1
Arm predicted mass (right) 0.2 0.9 2.8 -1.7 0.2 1.1 0.6 -0.3
Pulse rate, automated reading 2.1 6.8 13.2 -3.2 -2.2 -0.7 -2.3 3.6
Alcohol intake frequency. 2.4 5.6 9.2 -1.0 -2.8 -2.8 -1.5 3.0
Comparative height size at age 10 0.6 3.4 7.6 -0.6 1.7 2.8 2.1 -1.3
Number of full sisters 0.8 1.0 3.3 -0.2 -1.8 -0.7 -0.4 1.0
Suffer from ‘nerves’ 3.2 5.1 9.5 -0.3 -3.1 -1.7 -2.7 2.3
Overall health rating 3.3 7.2 12.7 -0.6 -3.0 -3.1 -2.1 3.6
Chest pain or discomfort 0.2 0.3 0.6 -0.5 0.5 -0.8 -0.5 0.3
Had major operations 1.2 1.3 3.6 -1.5 1.9 0.7 0.7 -0.3
Age at last live birth 0.8 1.1 2.6 0.7 1.6 0.6 0.8 -1.2
Family relationship satisfaction 0.9 1.1 2.5 0.2 1.6 1.5 0.4 -0.8
Leg pain on walking 0.7 0.8 2.8 1.7 -0.8 -0.6 -0.5 0.2
Qualifications: NVQ or HND or HNC or equivalent 1.9 2.2 5.1 -1.4 -1.6 -2.3 -0.9 1.0
Commuting to job workplace: Car/motor vehicle 0.9 1.0 3.4 0.1 -1.1 0.3 0.6 1.8
Illness, injury, bereavement, stress in last 2 years 2.1 2.5 5.4 0.7 2.2 1.3 0.3 -2.3
Medication: Aspirin 1.8 2.4 7.0 2.7 -0.8 -1.3 -1.6 -0.1
Supplements: Vitamin C 0.9 1.1 2.0 -0.4 -1.4 -1.0 -1.0 1.1
Knee pain experienced in last month 0.3 0.4 0.9 1.0 0.0 -0.2 0.6 -0.9
Hypertension (Self-reported) 1.8 4.9 9.1 2.5 -2.2 -2.1 -3.0 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.2 0.4 -0.5 -0.2 -0.4 0.3
Illnesses of father: Heart disease 0.2 0.3 1.0 0.1 -0.0 0.1 0.6 1.0
Illnesses of siblings: Diabetes 0.7 0.9 2.4 -0.8 -1.6 -0.7 0.6 0.7
Smoking status: Previous 0.5 0.7 2.2 -0.9 0.2 1.5 0.8 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 1.8 3.7 6.5 -2.4 1.6 1.9 2.5 -0.2
Whole body fat-free mass 0.2 1.4 4.9 -2.2 0.0 1.0 1.0 0.5
Leg fat-free mass (right) 0.3 1.6 5.2 -2.3 -0.9 0.3 0.6 1.2
Arm fat percentage (left) 5.6 22.2 36.0 -0.6 -5.7 -6.0 -4.2 4.9
Average weekly red wine intake 1.4 2.0 4.8 1.3 1.5 1.2 0.5 -2.2
Handedness (chirality/laterality): Left-handed 0.7 0.9 2.3 1.0 0.8 0.3 -0.6 -1.5
Mood swings 7.5 13.6 24.8 -0.2 -5.0 -3.2 -3.4 4.6
Loneliness, isolation 1.3 1.8 3.7 0.1 -1.5 -0.7 -1.9 1.6
Long-standing illness, disability or infirmity 0.7 1.0 2.5 0.9 0.6 -1.1 -1.6 0.5
Ever had bowel cancer screening 2.7 3.1 6.0 2.5 1.2 0.2 1.8 -2.2
Diabetes diagnosed by doctor 0.8 1.4 2.4 0.8 -1.5 -1.2 -1.0 1.2
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 3.6 0.7 1.1 0.0 0.2 -1.9
Friendships satisfaction 1.5 1.9 5.8 0.6 2.4 1.4 0.2 -1.1
Qualifications: nursing, teaching 8.5 13.2 23.1 -0.9 4.8 4.0 4.4 -2.4
Commuting to job workplace: Walk 1.4 1.5 2.6 -1.2 -1.6 -0.6 -1.6 0.7
Eye problems/disorders: Cataract 2.0 2.4 4.8 -2.2 1.9 1.6 0.8 -0.4
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 1.1 1.0 -0.2 -0.1 -1.0 0.2
Medication for cholesterol 0.2 0.4 0.8 -0.6 0.4 0.6 0.9 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 2.0 1.0 -0.7 -1.4 -0.3 -0.7
Back pain experienced in last month 0.7 1.1 2.1 -0.9 -1.0 -1.2 -0.6 1.4
Mineral and other dietary supplements 0.6 0.8 3.2 0.5 1.8 -0.5 0.2 -0.4
Breast cancer (self-reported) 0.5 0.6 2.3 -0.6 -0.1 0.2 1.5 0.2
Asthma (self-reported) 0.1 0.3 0.7 -0.8 0.1 -0.0 -0.6 0.5
Osteoporosis (self-reported) 0.4 0.4 1.1 0.6 -0.1 -0.8 -1.1 0.2
Osteoarthritis (self-reported) 0.3 0.4 1.3 1.1 0.2 0.4 0.7 -0.4
Medication: Aspirin 1.4 1.9 5.8 2.4 -1.0 -1.0 -1.2 0.5
Medication: Gliclazide 0.6 0.6 2.4 1.6 -0.2 -0.1 0.5 -0.6
Illnesses of father: None of the above (group 1) 0.1 0.1 0.3 0.1 0.2 -0.1 -0.6 0.2
Smoking status: Current 1.2 1.9 4.3 1.8 -0.5 -1.2 -2.1 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.1 2.4 5.3 -0.1 2.3 1.8 1.3 -1.3
Whole body water mass 0.3 1.4 5.0 -2.2 0.1 1.1 1.0 0.4
Leg predicted mass (right) 0.3 1.6 5.4 -2.3 -0.7 0.4 0.7 1.1
Arm fat mass (left) 3.7 15.3 25.4 -1.2 -5.0 -4.6 -3.2 4.3
Number of self-reported non-cancer illnesses 1.5 2.5 4.6 0.8 -2.1 -1.7 -1.9 0.9
Average weekly champagne plus white wine intake 1.9 2.6 5.6 0.1 2.2 0.7 1.4 -2.4
Miserableness 3.0 5.2 13.3 -0.3 -2.4 -1.9 -1.7 3.7
Guilty feelings 1.5 2.3 5.4 0.6 -2.3 -0.3 -1.9 1.4
Wears glasses or contact lenses 0.6 0.6 1.2 1.1 -0.2 -0.7 -1.1 -0.5
Ever taken oral contraceptive pill 1.0 1.1 4.6 -0.5 0.0 -0.2 -0.8 2.1
Hearing aid user 0.7 0.8 1.9 1.2 0.4 -1.4 -0.4 -0.6
Mother’s age at death 1.6 2.0 7.5 -2.7 -0.4 0.5 1.2 0.9
Financial situation satisfaction 2.8 3.5 7.3 1.8 -1.5 -2.1 -2.7 0.4
Tinnitus: Yes, now most or all of the time 0.8 1.0 4.5 -0.2 0.2 0.4 2.1 0.1
Commuting to job workplace: Public transport 1.2 1.4 2.3 -1.5 -0.9 -1.0 -1.0 1.5
Eye problems/disorders: Glaucoma 0.6 0.7 2.2 0.5 0.7 -0.2 -0.5 -1.5
Medication: Blood pressure 1.1 2.1 3.6 1.9 -1.1 -1.4 -1.7 -1.0
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.8 -0.3 -1.4 0.1 -0.0 0.8
Supplements: Fish oil (including cod liver oil) 1.2 1.6 5.8 -0.9 -2.4 0.7 0.2 1.1
High cholesterol (Self-reported) 0.4 0.8 1.2 0.9 -1.0 -1.1 0.0 0.9
Medication: Bendroflumethiazide 1.2 1.8 3.1 1.0 -1.6 -0.4 -1.8 1.4
Medication: Paracetamol 0.5 0.8 2.1 1.5 0.8 0.2 0.5 -1.0
Medication: Lisinopril 1.9 2.4 3.9 -0.1 -2.0 -1.8 -1.9 1.1
Medication: Atorvastatin 1.3 1.6 3.1 -0.7 -1.3 -1.8 0.6 1.5
Illnesses of father: High blood pressure 0.2 0.3 1.0 -0.4 -0.1 1.0 0.2 -0.4
Alcohol drinker status: Never 0.4 0.4 1.0 0.8 -1.0 -0.1 -0.4 0.7
Ever smoked 0.6 1.0 1.4 0.9 1.2 0.8 -0.8 -1.1
Basal metabolic rate 0.3 1.5 5.1 -2.2 -0.9 0.1 0.3 1.3
Leg fat percentage (left) 6.6 23.8 41.7 0.3 -5.7 -6.5 -4.8 4.7
Arm fat-free mass (left) 0.2 1.0 4.3 -2.1 -0.3 0.6 0.4 0.6
Number of operations (self-reported) 0.9 1.3 3.2 -0.3 1.5 0.8 1.8 -0.5
Average weekly beer plus cider intake 0.7 0.9 2.1 0.3 -1.1 -1.1 -1.4 0.3
Irritability 2.6 4.5 6.4 0.8 -2.3 -1.9 -2.5 2.5
Risk taking 1.2 1.7 4.5 1.0 1.7 0.2 0.3 -2.1
Ever had prostate specific antigen (PSA) test 0.7 0.8 1.4 -0.3 0.8 1.1 1.0 -1.2
Fractured/broken bones in last 5 years 1.1 1.4 2.5 -1.0 0.9 1.6 1.5 -0.7
Age started oral contraceptive pill 0.1 0.1 0.4 -0.0 -0.3 0.2 -0.6 0.3
Diastolic blood pressure, automated reading 1.5 4.7 10.1 -0.5 -3.0 -1.2 -3.2 1.6
Ever depressed for a whole week 0.3 0.3 0.6 -0.8 0.5 0.8 -0.2 0.3
Unable to work because of sickness or disability 3.6 4.6 10.2 1.8 -1.9 -3.2 -2.4 0.7
Commuting to job workplace: Cycle 2.6 3.1 7.1 -0.1 2.3 2.7 1.6 -0.8
Myopia 2.4 3.5 7.5 1.8 -2.7 -2.1 -1.4 0.6
Vascular/heart problems diagnosed by doctor 2.0 5.5 9.1 -2.3 2.7 2.4 3.0 -0.5
Cholesterol lowering medication 0.2 0.3 0.8 0.0 0.9 0.2 0.7 -0.0
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 2.5 -1.3 -1.4 -0.3 -0.2 1.6
Pain experienced in last month 1.0 1.7 3.6 -0.2 1.6 1.1 1.1 -1.9
Supplements: Calcium 1.3 1.4 2.6 -1.1 -1.5 -0.6 -0.9 1.6
Basal cell carcinoma (self-reported) 0.5 0.6 1.5 -0.0 0.2 1.1 0.5 -1.2
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.5 0.7 0.1 -0.2 -0.4 0.0
Deep venous thrombosis (DVT) (self-reported) 0.1 0.2 0.6 0.1 -0.8 -0.4 0.1 -0.2
Heart disease (siblings) 1.9 2.3 5.1 0.2 -2.3 -1.1 -1.7 1.5
Alcohol drinker status: Previous 0.9 1.0 2.0 -0.7 -0.5 -1.4 -1.4 0.8
Pack years of smoking 2.1 3.1 6.8 1.0 -1.9 -2.6 -1.6 1.3
Impedance of whole body 0.0 0.2 0.4 0.4 -0.1 -0.5 -0.3 -0.6
Leg fat mass (left) 4.0 15.4 24.4 -0.7 -4.9 -4.9 -3.5 4.0
Arm predicted mass (left) 0.2 0.8 3.3 -1.8 -0.3 0.6 0.4 0.4