Hub : Genes

TAOK3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 NTR Blood 0.0277 0.0091 8.8e-05 0.008 0.011 0.016 0.011 0.015 0.00084 0.00011 4.1e-06 9.1e-05 7.5e-06
2 TCGA Lung Adenocarcinoma 0.0202 0.0133 6.8e-03 0.008 0.003 -0.002 NA -0.001 0.03300 0.12000 6.0e-01 NA 5.3e-01
3 TCGA Ovarian Serous Cystadenocarcinoma 0.0380 0.0240 8.2e-03 0.024 0.027 0.000 NA 0.010 0.00850 0.00570 3.3e-01 NA 6.5e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.2 0.3 0.5 0.4 -0.5 0.7
Bipolar Disorder or Schizophrenia 0.7 1.6 2.4 1.6 -1.2 1.0
Depressed Affect (Nagel 2018) 5.5 11.6 17.9 -1.7 3.8 4.2
Depression (Nagel 2018) 9.7 14.6 21.1 -2.2 4.2 4.6
Intelligence (Savage-Jansen 2018) 0.9 2.9 5.2 -0.4 1.8 2.3
Neuroticism (Nagel 2018) 9.2 21.7 37.3 -2.2 4.8 6.1
Schizophrenia (2018) 0.7 1.5 2.7 1.7 -1.1 0.8
Schizophrenia vs Biploar Disorder 0.2 0.3 0.7 0.8 -0.4 -0.1
Worry (Nagel 2018) 4.1 8.6 15.1 -1.1 3.0 3.9
Alzheimer’s Disease (in mother) 0.9 1.0 3.0 0.4 -0.0 -1.7
Alzheimer’s Disease (in father) 0.4 0.5 1.1 0.2 1.0 0.5
Alzheimer’s Disease (including proxy) 0.4 0.6 1.7 -0.3 1.3 -0.0
Crohns Disease (2017) 0.2 0.4 0.6 0.8 -0.2 0.7
Irritable Bowel Disease (IBD) 0.6 1.4 3.8 2.0 -0.5 0.5
Ulcerative Colitis (UC) 0.7 1.4 3.8 1.9 -0.6 -0.2
Major Depression (MDD) 7.4 9.0 18.2 -1.6 2.5 4.3
Reaction Time 1.9 3.6 5.7 -1.6 1.5 2.4
Verbal and Numeric Reasoning (VNR) 0.9 2.2 4.0 -0.8 1.4 2.0
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 0.7 1.0 1.6 -0.7 0.9 1.3
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.4 0.6 0.9 0.9 -0.4 0.9
Bipolar Disorder (2011) 0.5 0.5 1.1 1.0 -0.6 0.2
Body Mass Index (BMI) (2010) 0.4 0.6 1.0 0.6 -1.0 -0.5
Coronary Artery Disease (CAD) 0.8 1.0 1.8 -1.0 0.4 1.3
Crohns Disease (2012) 0.3 0.5 0.6 0.5 -0.8 0.7
Mean Putamen Volume 2.3 2.6 4.1 1.8 -2.0 -0.6
Fasting Glucose 0.9 1.1 2.9 -1.7 0.6 0.1
HbA1C 1.1 1.2 2.2 -1.5 1.1 -0.2
HDL Cholesterol 1.6 2.6 5.0 -0.7 -1.6 -2.2
LDL Cholesterol 0.9 1.5 1.7 -1.3 1.2 1.2
Lupus 0.2 0.3 0.9 0.3 0.0 0.9
Neuroticism (2016) 14.0 20.2 24.2 -3.5 4.9 4.9
Primary Biliary Cirrhosis 0.0 0.0 0.1 -0.0 0.3 -0.2
Rheumatoid Arthritis 0.2 0.3 0.4 -0.4 0.6 0.5
Schizophrenia (2014) 1.0 2.2 3.4 1.9 -0.6 1.6
Triglycerides 0.2 0.4 0.8 0.9 -0.3 0.5
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.3 0.5 0.3 0.6
Ulcerative Colitis 1.3 2.0 4.7 2.2 -0.9 -0.6
Blood Eosinophil Count 0.2 1.6 4.2 -2.1 -0.0 -0.8
Blood Platelet Count 0.2 2.7 3.3 -1.8 1.7 1.3
Blood Red Count 0.5 4.9 12.0 0.6 -1.5 -3.5
Blood White Count 0.3 1.9 4.9 -0.4 -0.7 -2.2
Heel T-Score 0.0 0.3 0.4 0.6 -0.6 -0.5
BMI 0.3 1.5 2.7 0.0 -1.6 -1.4
Height 0.3 6.0 10.7 1.3 -2.4 -3.3
Waist Hip Ratio (WHR) 0.1 0.4 0.6 0.2 -0.7 -0.8
Systolic Blood Pressure 0.3 1.5 1.8 -1.0 1.3 1.4
Smoking Status 1.0 2.3 5.0 -2.2 1.4 0.3
Allergy or Eczema 0.1 0.3 0.7 0.8 -0.6 -0.2
Cardiovascular Disease 0.6 1.9 5.3 -2.3 -0.4 0.6
Hypothyroidism (self reported) 0.4 1.0 1.8 -0.7 1.3 0.7
Respiratory disease 0.2 0.4 0.7 0.8 -0.8 -0.1
Type 2 Diabetes (T2D) (2018) 0.1 0.1 0.2 0.1 -0.4 0.4
Lung FEV1/FVC ratio 0.1 0.3 0.5 -0.7 0.2 0.5
Lung FVC 0.5 2.3 5.7 -0.6 2.4 1.0
Neuroticism 11.2 27.0 46.8 -2.4 5.3 6.8
Chronotype (morning person) 1.2 2.8 4.5 -1.3 1.5 2.1
Hair Pigment 0.0 1.3 2.0 0.6 -1.2 -1.4
Tanning 0.0 0.3 0.9 -0.1 0.2 -1.0
Hand grip strength (left) 0.9 2.3 6.8 -0.3 -0.4 -2.6
Number of treatments/medications taken 1.1 1.9 3.8 -1.0 0.9 1.9
Average weekly spirits intake 0.6 0.7 1.5 0.7 -1.2 0.4
Sensitivity / hurt feelings 8.5 14.5 18.4 -3.3 3.8 4.3
Frequency of depressed mood in last 2 weeks 8.1 11.4 19.3 -1.7 3.5 4.4
Hearing difficulty/problems: Yes 0.7 1.0 1.9 -0.3 1.4 1.0
Relative age of first facial hair 0.0 0.0 0.1 -0.1 0.1 0.2
Other serious medical condition/disability diagnosed by doctor 1.3 1.6 2.6 -1.1 1.1 1.6
Ever used hormone-replacement therapy (HRT) 0.8 1.1 1.9 -0.4 1.1 1.4
Ever had hysterectomy (womb removed) 0.1 0.2 0.2 -0.5 0.3 -0.4
Systolic blood pressure, automated reading 0.5 1.4 2.3 -0.8 1.5 1.2
Eye problems/disorders: Diabetes related eye disease 0.0 0.0 0.1 -0.1 -0.2 0.2
Angina 1.5 2.0 3.0 -1.2 1.2 1.7
Medication for hormone replacement therapy 1.0 1.1 1.6 -1.2 1.3 0.6
Vitamin and mineral supplements 1.0 1.3 2.2 -0.7 -1.1 -1.5
Supplements: Zinc 1.2 1.3 1.8 1.4 -1.3 -0.6
Medication: Co-codamol 0.5 0.6 1.3 0.6 -0.2 1.2
Medication: Metformin 0.5 0.7 2.0 0.5 -1.4 -0.2
Diabetes (father) 0.8 0.9 1.5 -0.7 1.2 0.9
Diabetes (mother) 2.0 2.6 4.4 0.7 -1.7 -2.1
Severe depression (siblings) 0.0 0.0 0.1 -0.3 0.1 0.1
Pack years adult smoking proportion 0.2 0.3 0.6 -0.3 -0.4 -0.8
Impedance of leg (right) 0.4 1.8 3.7 0.5 -1.2 -1.9
Leg fat-free mass (left) 0.0 0.2 0.3 0.0 -0.5 -0.5
Trunk fat percentage 1.1 4.4 10.6 -1.1 -1.2 -3.2
Hand grip strength (right) 0.2 0.6 1.6 -0.4 0.3 -1.3
Townsend deprivation index at recruitment 1.1 1.5 2.6 -0.8 1.6 1.1
Current tobacco smoking 1.0 1.7 2.1 -1.3 1.5 1.1
Average weekly fortified wine intake 1.4 1.7 3.0 -1.7 0.9 1.1
Maternal smoking around birth 0.0 0.1 0.2 -0.1 0.0 0.4
Fed-up feelings 4.8 8.8 13.6 -1.5 3.7 3.3
Frequency of unenthusiasm / disinterest in last 2 weeks 7.4 9.9 15.0 -1.8 3.9 3.4
Relative age voice broke 0.1 0.2 0.4 0.0 -0.6 -0.5
Taking other prescription medications 3.2 4.9 9.0 -2.0 1.3 3.0
Age when periods started (menarche) 0.1 0.3 0.4 -0.6 -0.0 0.7
Bilateral oophorectomy (both ovaries removed) 1.5 1.7 2.9 -1.0 1.7 1.2
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 0.8 -0.3 0.9 0.6
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.2 -0.4 0.1 -0.4
Qualifications: CSEs or equivalent 1.1 1.4 2.2 0.4 -1.5 -1.4
Serious illness, injury or assault to yourself 1.2 1.4 2.0 1.1 -1.4 -1.1
High blood pressure 0.2 0.4 1.1 -1.1 0.1 0.3
Hayfever, allergic rhinitis or eczema 0.3 0.7 0.9 0.9 -1.0 -0.6
Multivitamins +/- minerals 0.5 0.6 1.4 1.2 -0.4 0.7
Stomach or abdominal pain in last month 1.0 1.3 2.3 0.7 1.0 1.5
Supplements: Glucosamine 0.2 0.2 0.3 0.5 0.4 0.5
Diverticular disease/diverticulitis (self-reported) 0.9 1.1 1.4 0.7 -1.2 -1.1
Medication: Atenolol 0.7 0.8 1.7 -0.2 1.3 0.9
Medication: Levothyroxine sodium 1.1 1.8 2.9 -0.2 1.7 1.6
Sitting height 0.0 0.1 0.3 0.6 -0.1 -0.0
Chronic bronchitis/emphysema (father) 2.4 2.8 6.6 -0.7 -1.1 -2.6
High blood pressure (mother) 0.0 0.1 0.1 -0.0 -0.4 -0.2
Body mass index (BMI) 0.2 0.8 1.3 -1.0 -0.4 -1.1
Impedance of leg (left) 0.2 1.0 2.1 0.3 -0.9 -1.4
Leg predicted mass (left) 0.0 0.2 0.3 0.0 -0.5 -0.5
Trunk fat mass 0.8 3.6 8.3 -1.1 -1.2 -2.9
Waist circumference 0.3 1.2 2.3 -1.5 -0.1 -1.1
Number of incorrect matches in round 0.4 0.7 1.6 0.5 -0.4 -1.3
Past tobacco smoking 0.2 0.4 0.7 0.8 -0.3 0.5
Alcohol usually taken with meals 0.7 1.2 1.8 1.3 -1.4 -0.3
Nervous feelings 1.3 2.4 3.8 -0.3 1.8 1.9
Frequency of tenseness / restlessness in last 2 weeks 3.6 5.6 9.1 -1.1 3.0 2.5
Hearing difficulty/problems with background noise 4.1 6.6 8.8 -1.9 3.0 2.7
Hair/balding pattern: Pattern 2 0.6 0.8 1.6 0.7 0.5 1.3
Had menopause 0.0 0.1 0.1 0.2 0.3 -0.0
Had other major operations 0.1 0.2 0.3 -0.4 0.0 -0.5
Forced vital capacity (FVC) 0.2 0.6 1.4 -0.1 1.2 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.0 0.1 0.2 -0.2 0.1 -0.4
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.1 -0.2 0.4 -0.2
Qualifications: None of the above 0.8 1.6 3.3 -1.8 1.3 0.1
Financial difficulties in last 2 years 0.9 1.2 2.5 -0.3 1.0 1.6
Mouth/teeth dental problems 1.9 2.9 4.7 0.8 -2.2 -1.8
Heart attack 0.2 0.2 0.5 -0.7 0.4 -0.0
Allergy 0.1 0.2 0.3 -0.1 0.6 0.5
Pain all over the body in last month 1.8 1.9 2.3 -1.4 1.5 1.2
Diabetes (self-reported) 0.1 0.2 0.5 -0.2 -0.3 0.7
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 0.5 -0.7 0.3 0.7
Medication: Ramipril 1.0 1.3 2.1 -1.5 1.4 0.0
Medication: Simvastatin 0.3 0.5 0.9 -0.8 -0.1 0.9
Fluid intelligence score 0.6 1.2 2.6 1.0 -0.3 1.6
Illnesses of siblings 0.1 0.2 0.5 -0.1 0.7 0.1
Neuroticism score 4.9 10.2 18.0 -1.1 3.3 4.2
Weight 0.3 1.4 3.0 -0.5 -0.9 -1.7
Impedance of arm (right) 1.6 7.6 15.8 1.4 -2.3 -4.0
Arm fat percentage (right) 1.3 5.1 12.2 -0.8 -1.6 -3.5
Trunk fat-free mass 0.0 0.2 0.4 0.2 -0.6 0.2
Hip circumference 0.1 0.5 0.8 -0.9 -0.2 -0.7
Time employed in main current job 0.3 0.3 0.6 0.6 -0.7 -0.1
Alcohol intake versus 10 years previously 0.1 0.1 0.2 -0.3 0.4 -0.3
Father’s age at death 0.0 0.1 0.1 -0.1 0.3 0.2
Worrier / anxious feelings 3.2 6.1 9.1 -1.4 2.7 3.0
Frequency of tiredness / lethargy in last 2 weeks 6.0 9.7 15.4 -1.4 3.9 3.4
Falls in the last year 0.1 0.2 0.3 -0.2 0.5 0.5
Hair/balding pattern: Pattern 3 1.4 2.0 3.2 -1.0 1.8 1.4
Number of live births 1.0 1.4 2.4 -0.7 -1.1 -1.5
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 1.6 -0.6 1.3 -0.5
Pulse rate 0.0 0.1 0.2 0.2 -0.4 -0.1
Happiness 0.2 0.2 0.4 0.4 -0.6 -0.2
Noisy workplace 0.4 0.5 1.0 -0.7 1.0 0.3
Qualifications: A levels/AS levels or equivalent 0.0 0.1 0.2 0.5 -0.2 -0.2
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.1 3.1 -1.8 0.1 -0.2
Mouth/teeth dental problems: Dentures 3.1 5.2 7.7 -2.1 2.8 1.8
Asthma 0.1 0.2 0.5 0.2 -0.7 -0.1
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.2 0.6 -0.6 -1.1
Medication: Cholesterol lowering 0.1 0.1 0.2 -0.2 -0.1 0.4
Depression (self-reported) 0.9 1.1 2.1 -0.7 0.8 1.5
Medication: Lansoprazole 0.0 0.0 0.1 0.1 -0.3 -0.2
Prospective memory result 0.0 0.0 0.0 -0.1 0.2 -0.1
Lung cancer (father) 2.1 2.4 3.5 -1.9 1.8 0.8
Illnesses of mother 0.2 0.3 0.8 -0.2 0.1 0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 0.8 -0.4 0.9 -0.2
Pulse wave Arterial Stiffness index 2.8 3.3 6.7 -0.7 1.7 2.6
Impedance of arm (left) 1.5 7.1 15.5 1.1 -2.2 -3.9
Arm fat mass (right) 0.6 2.6 5.8 -0.6 -1.2 -2.4
Trunk predicted mass 0.0 0.2 0.4 0.2 -0.6 0.2
Standing height 0.2 2.2 2.9 1.1 -1.6 -1.7
Length of working week for main job 0.7 0.8 2.0 -0.2 1.4 0.6
Exposure to tobacco smoke at home 0.4 0.5 1.1 -1.0 0.3 -0.5
Breastfed as a baby 0.9 1.1 2.7 0.7 -1.6 -0.0
Tense / ‘highly strung’ 0.6 1.0 1.7 -0.6 0.9 1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 2.4 3.7 10.3 0.0 0.9 3.2
Hair/balding pattern: Pattern 4 1.1 2.6 3.4 -1.8 1.5 1.4
Birth weight of first child 0.2 0.3 0.5 -0.6 -0.5 -0.7
Peak expiratory flow (PEF) 0.6 1.5 3.2 -1.8 0.8 -0.8
Pulse wave reflection index 0.7 0.9 1.8 -0.3 0.9 1.3
Ever highly irritable/argumentative for 2 days 0.5 0.5 0.9 0.6 0.9 0.7
Loud music exposure frequency 0.6 0.6 1.6 -0.3 1.3 -0.4
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 1.7 1.3 -0.8 -0.6
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 1.8 -0.3 1.1 1.4
Blood clot in the leg (DVT) 0.2 0.2 0.6 -0.8 0.3 -0.1
Medication: Paracetamol 0.7 1.1 2.6 -1.6 -0.0 -0.9
Headache pain in last month 0.1 0.3 0.3 0.6 0.5 0.5
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.5 0.7 -0.0 -0.7
Glaucoma (self-reported) 0.3 0.4 1.1 0.2 0.2 1.1
Gout (self-reported) 2.0 2.8 5.0 -0.5 2.2 1.8
Hypothyroidism/myxoedema (self-reported) 0.5 0.9 1.7 -0.2 1.3 1.1
Medication: Amlodipine 0.4 0.5 1.5 0.2 -1.2 -0.3
Medication: Ventolin 100micrograms inhaler 0.3 0.3 0.9 0.3 -0.0 1.0
Birth weight 1.0 2.1 3.6 0.3 -1.6 -1.9
Chronic bronchitis/emphysema (mother) 0.2 0.3 0.3 -0.6 0.5 0.5
High blood pressure (siblings) 0.7 1.1 1.9 0.6 -1.0 -1.4
Forced vital capacity (FVC), Best measure 0.1 0.3 0.6 -0.3 0.8 -0.4
Body fat percentage 1.1 4.3 9.8 -1.4 -1.1 -3.1
Leg fat percentage (right) 0.8 3.0 6.0 -1.6 -0.6 -2.5
Arm fat-free mass (right) 0.1 0.6 1.2 -0.6 0.3 1.1
Exposure to tobacco smoke outside home 3.8 5.1 5.3 -2.3 2.3 2.2
Comparative body size at age 10 0.8 2.1 2.4 1.6 -1.5 -1.3
Number of full brothers 0.3 0.4 0.7 0.1 0.8 0.7
Worry too long after embarrassment 3.5 5.9 11.7 -0.2 2.5 3.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.2 0.1 -0.1 0.5
Wheeze or whistling in the chest in last year 0.2 0.3 0.4 -0.6 0.6 0.5
Number of children fathered 0.7 0.8 1.6 -1.3 0.9 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 0.8 0.6 -0.8 0.9
Age at first live birth 3.0 5.3 8.9 2.5 -3.0 -0.8
Pulse wave peak to peak time 2.9 3.5 7.0 0.7 -1.7 -2.6
Health satisfaction 0.1 0.1 0.1 0.3 -0.2 0.2
Shortness of breath walking on level ground 2.2 2.6 4.0 -1.0 2.0 1.7
Qualifications: College or University degree 0.5 1.5 3.2 1.1 -1.8 -0.3
Eye problems/disorders: None of the above 1.1 1.2 3.0 -0.1 1.7 0.8
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.2 0.4 0.4 -0.1
Emphysema/chronic bronchitis 0.9 1.0 1.7 -0.4 1.3 1.0
Medication for pain relief, constipation, heartburn 0.4 0.8 1.3 1.2 0.4 0.9
Neck or shoulder pain in last month 1.1 1.6 2.6 -0.1 1.5 1.6
Medication: Blood pressure 0.4 0.7 1.7 -1.3 0.6 0.2
Angina (self-reported) 1.3 1.7 2.7 -1.0 1.1 1.6
Migraine (self-reported) 5.7 7.0 9.6 2.7 -3.1 -2.1
Medication: Ibuprofen 0.0 0.0 0.1 0.2 0.2 -0.1
Medication: Allopurinol 0.3 0.4 0.9 0.2 0.9 0.6
Medication: Omeprazole 1.1 1.4 3.1 -1.0 0.2 1.8
Medication: Seretide 50 evohaler 0.0 0.0 0.1 0.2 -0.0 0.3
Mean time to correctly identify matches 1.7 3.2 5.2 -1.5 1.4 2.3
Heart disease (mother) 0.2 0.2 0.4 0.4 -0.1 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.3 0.6 0.1 0.6
Whole body fat mass 0.7 3.0 6.6 -1.1 -1.1 -2.6
Leg fat mass (right) 0.6 2.2 4.5 -1.3 -0.6 -2.1
Arm predicted mass (right) 0.1 0.5 0.9 -0.7 0.3 1.0
Pulse rate, automated reading 0.1 0.3 0.7 0.4 -0.8 -0.1
Alcohol intake frequency. 0.1 0.3 0.4 -0.4 -0.5 -0.6
Comparative height size at age 10 0.5 2.6 6.1 -0.1 -1.3 -2.5
Number of full sisters 0.4 0.5 1.3 0.3 0.5 1.1
Suffer from ‘nerves’ 4.2 6.7 9.2 -1.7 2.8 3.0
Overall health rating 2.3 5.0 6.7 -1.4 2.6 2.5
Chest pain or discomfort 3.1 4.5 8.2 -0.3 2.3 2.9
Had major operations 1.7 2.0 4.3 0.0 -1.2 -2.1
Age at last live birth 2.6 3.8 6.7 1.9 -2.6 -1.1
Family relationship satisfaction 0.7 0.9 1.1 -1.0 0.8 1.1
Leg pain on walking 0.3 0.3 0.5 -0.7 0.4 -0.6
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 3.5 1.9 -0.4 -0.0
Commuting to job workplace: Car/motor vehicle 0.7 0.8 1.3 -0.8 1.1 0.7
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 1.1 1.0 -0.1 -0.0
Medication: Aspirin 0.2 0.2 0.4 -0.6 0.1 -0.6
Supplements: Vitamin C 0.3 0.4 0.8 0.9 0.5 0.5
Knee pain experienced in last month 2.3 3.6 5.8 -1.9 2.4 1.1
Hypertension (Self-reported) 0.2 0.6 1.7 -1.3 0.1 0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.2 0.4 -0.0 -0.3 0.6
Illnesses of father: Heart disease 2.9 4.0 6.0 1.9 -2.5 -1.4
Illnesses of siblings: Diabetes 0.3 0.3 0.5 0.7 -0.4 0.5
Smoking status: Previous 0.2 0.3 0.6 -0.8 0.2 -0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 1.1 1.0 -0.6 0.2
Whole body fat-free mass 0.0 0.1 0.2 0.1 -0.5 0.1
Leg fat-free mass (right) 0.0 0.0 0.0 0.0 -0.2 -0.1
Arm fat percentage (left) 1.1 4.5 10.6 -1.1 -1.3 -3.2
Average weekly red wine intake 1.3 1.9 2.8 1.7 -1.7 -0.4
Handedness (chirality/laterality): Left-handed 1.2 1.5 1.9 0.9 -1.3 -1.4
Mood swings 2.2 4.0 8.1 -0.1 2.0 2.9
Loneliness, isolation 8.7 12.1 17.6 -2.2 3.7 4.2
Long-standing illness, disability or infirmity 1.2 1.9 2.0 -1.4 1.4 1.3
Ever had bowel cancer screening 0.5 0.6 0.9 -0.9 0.4 -0.9
Diabetes diagnosed by doctor 0.0 0.1 0.1 -0.3 -0.3 0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.0 0.0 0.0 0.1 -0.0 -0.1
Friendships satisfaction 0.6 0.8 1.3 -0.4 0.9 1.2
Qualifications: nursing, teaching 1.5 2.4 5.0 1.0 -2.2 -1.1
Commuting to job workplace: Walk 0.2 0.2 0.5 -0.4 -0.1 -0.7
Eye problems/disorders: Cataract 0.9 1.1 1.7 1.2 -1.3 -0.2
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 0.7 0.8 -0.5 -0.6
Medication for cholesterol 0.6 0.9 1.5 1.2 0.4 1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.5 0.7 -0.7 0.2
Back pain experienced in last month 0.4 0.5 0.8 0.3 0.9 0.9
Mineral and other dietary supplements 0.8 1.1 2.6 -1.6 0.8 0.4
Breast cancer (self-reported) 1.5 1.8 3.7 -1.9 1.3 -0.2
Asthma (self-reported) 0.1 0.2 0.6 0.4 -0.8 0.0
Osteoporosis (self-reported) 2.4 3.0 5.9 2.4 -1.4 -1.1
Osteoarthritis (self-reported) 0.3 0.4 0.6 -0.7 0.8 0.4
Medication: Aspirin 0.3 0.4 1.0 -1.0 0.4 -0.1
Medication: Gliclazide 0.2 0.3 0.3 0.5 -0.6 0.5
Illnesses of father: None of the above (group 1) 1.4 1.7 3.8 -0.1 1.1 2.0
Smoking status: Current 0.5 0.8 1.1 -1.0 1.0 0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.2 2.0 -1.1 1.4 0.7
Whole body water mass 0.0 0.1 0.2 0.1 -0.4 0.2
Leg predicted mass (right) 0.0 0.0 0.0 -0.1 -0.2 -0.1
Arm fat mass (left) 0.6 2.6 6.0 -0.9 -1.1 -2.4
Number of self-reported non-cancer illnesses 0.9 1.5 3.8 -0.5 0.7 2.0
Average weekly champagne plus white wine intake 0.2 0.3 0.7 -0.2 0.3 0.8
Miserableness 1.7 2.9 4.6 -0.5 2.0 2.2
Guilty feelings 7.2 10.9 14.3 -2.7 3.8 3.4
Wears glasses or contact lenses 0.6 0.7 1.2 -1.1 0.4 -0.9
Ever taken oral contraceptive pill 0.1 0.1 0.2 -0.1 -0.4 -0.4
Hearing aid user 0.7 0.8 1.4 1.2 -0.6 0.9
Mother’s age at death 1.2 1.6 2.3 -0.1 -1.5 -1.5
Financial situation satisfaction 1.8 2.3 2.9 1.6 -1.1 -1.7
Tinnitus: Yes, now most or all of the time 2.3 2.7 4.1 -0.9 2.0 1.8
Commuting to job workplace: Public transport 3.0 3.6 4.5 1.7 -2.1 -1.8
Eye problems/disorders: Glaucoma 0.7 0.8 2.0 -1.4 0.4 0.5
Medication: Blood pressure 0.2 0.3 0.7 -0.9 0.1 0.4
Pain type(s) experienced in last month: Hip pain 0.3 0.3 0.5 0.1 0.7 0.7
Supplements: Fish oil (including cod liver oil) 1.5 2.0 3.0 1.7 -1.5 -0.8
High cholesterol (Self-reported) 0.4 0.8 1.2 -1.0 -0.2 1.1
Medication: Bendroflumethiazide 0.0 0.1 0.2 0.1 -0.4 0.2
Medication: Paracetamol 0.4 0.6 1.4 -1.2 0.2 -0.5
Medication: Lisinopril 1.5 1.9 4.9 -2.2 0.1 -1.0
Medication: Atorvastatin 0.6 0.7 1.0 -0.6 0.8 1.0
Illnesses of father: High blood pressure 0.3 0.4 0.8 -0.9 0.6 -0.2
Alcohol drinker status: Never 0.0 0.1 0.2 -0.4 -0.1 -0.1
Ever smoked 0.6 1.0 1.9 -1.4 0.7 -0.8
Basal metabolic rate 0.0 0.2 0.4 -0.1 -0.6 -0.4
Leg fat percentage (left) 0.6 2.3 4.0 -1.7 -0.3 -2.0
Arm fat-free mass (left) 0.0 0.2 0.5 -0.4 0.0 0.7
Number of operations (self-reported) 1.3 1.9 3.0 -1.7 1.6 0.2
Average weekly beer plus cider intake 1.1 1.6 2.5 -1.0 1.6 1.1
Irritability 2.5 4.2 8.4 -0.5 2.0 2.9
Risk taking 0.7 1.0 2.0 1.4 -0.7 -0.7
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.3 -0.5 0.3 -0.5
Fractured/broken bones in last 5 years 1.2 1.5 3.0 1.0 0.7 1.7
Age started oral contraceptive pill 1.6 2.0 2.8 1.0 -1.7 -1.5
Diastolic blood pressure, automated reading 1.2 3.8 5.1 -2.1 2.2 1.4
Ever depressed for a whole week 1.3 1.6 2.7 0.9 1.2 1.7
Unable to work because of sickness or disability 1.2 1.5 2.2 -1.4 0.7 1.5
Commuting to job workplace: Cycle 0.6 0.7 1.5 1.2 0.2 0.9
Myopia 0.2 0.3 0.5 0.7 0.6 0.2
Vascular/heart problems diagnosed by doctor 0.7 1.8 3.5 1.9 -0.9 -1.0
Cholesterol lowering medication 0.4 0.6 1.5 -0.2 -0.3 1.2
Medication: Omeprazole (e.g. Zanprol) 1.3 1.6 2.4 -1.5 0.5 1.5
Pain experienced in last month 1.9 3.2 4.9 1.6 -2.2 -1.4
Supplements: Calcium 0.8 0.8 2.2 1.5 -0.5 0.2
Basal cell carcinoma (self-reported) 0.5 0.6 1.0 1.0 -0.8 -0.5
Heart attack/myocardial infarction (self-reported) 0.5 0.7 1.5 -1.2 0.8 0.1
Deep venous thrombosis (DVT) (self-reported) 0.1 0.2 0.4 -0.7 0.3 -0.1
Heart disease (siblings) 2.8 3.4 4.1 -2.0 1.8 1.8
Alcohol drinker status: Previous 1.9 2.2 5.0 -2.2 0.8 0.9
Pack years of smoking 0.3 0.4 0.7 -0.7 -0.1 -0.9
Impedance of whole body 0.7 3.6 8.0 0.6 -1.5 -2.8
Leg fat mass (left) 0.4 1.7 3.2 -1.3 -0.4 -1.8
Arm predicted mass (left) 0.0 0.2 0.5 -0.3 0.0 0.7