Hub : Genes

TAOK3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0277	0.0091	8.8e-05	0.008	0.011	0.016	0.011	0.015	0.00084	0.00011	4.1e-06	9.1e-05	7.5e-06
2	TCGA	Lung Adenocarcinoma	0.0202	0.0133	6.8e-03	0.008	0.003	-0.002	NA	-0.001	0.03300	0.12000	6.0e-01	NA	5.3e-01
3	TCGA	Ovarian Serous Cystadenocarcinoma	0.0380	0.0240	8.2e-03	0.024	0.027	0.000	NA	0.010	0.00850	0.00570	3.3e-01	NA	6.5e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.2	0.3	0.5	0.4	-0.5	0.7
Bipolar Disorder or Schizophrenia	0.7	1.6	2.4	1.6	-1.2	1.0
Depressed Affect (Nagel 2018)	5.5	11.6	17.9	-1.7	3.8	4.2
Depression (Nagel 2018)	9.7	14.6	21.1	-2.2	4.2	4.6
Intelligence (Savage-Jansen 2018)	0.9	2.9	5.2	-0.4	1.8	2.3
Neuroticism (Nagel 2018)	9.2	21.7	37.3	-2.2	4.8	6.1
Schizophrenia (2018)	0.7	1.5	2.7	1.7	-1.1	0.8
Schizophrenia vs Biploar Disorder	0.2	0.3	0.7	0.8	-0.4	-0.1
Worry (Nagel 2018)	4.1	8.6	15.1	-1.1	3.0	3.9
Alzheimer’s Disease (in mother)	0.9	1.0	3.0	0.4	-0.0	-1.7
Alzheimer’s Disease (in father)	0.4	0.5	1.1	0.2	1.0	0.5
Alzheimer’s Disease (including proxy)	0.4	0.6	1.7	-0.3	1.3	-0.0
Crohns Disease (2017)	0.2	0.4	0.6	0.8	-0.2	0.7
Irritable Bowel Disease (IBD)	0.6	1.4	3.8	2.0	-0.5	0.5
Ulcerative Colitis (UC)	0.7	1.4	3.8	1.9	-0.6	-0.2
Major Depression (MDD)	7.4	9.0	18.2	-1.6	2.5	4.3
Reaction Time	1.9	3.6	5.7	-1.6	1.5	2.4
Verbal and Numeric Reasoning (VNR)	0.9	2.2	4.0	-0.8	1.4	2.0
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.7	1.0	1.6	-0.7	0.9	1.3
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.4	0.6	0.9	0.9	-0.4	0.9
Bipolar Disorder (2011)	0.5	0.5	1.1	1.0	-0.6	0.2
Body Mass Index (BMI) (2010)	0.4	0.6	1.0	0.6	-1.0	-0.5
Coronary Artery Disease (CAD)	0.8	1.0	1.8	-1.0	0.4	1.3
Crohns Disease (2012)	0.3	0.5	0.6	0.5	-0.8	0.7
Mean Putamen Volume	2.3	2.6	4.1	1.8	-2.0	-0.6
Fasting Glucose	0.9	1.1	2.9	-1.7	0.6	0.1
HbA1C	1.1	1.2	2.2	-1.5	1.1	-0.2
HDL Cholesterol	1.6	2.6	5.0	-0.7	-1.6	-2.2
LDL Cholesterol	0.9	1.5	1.7	-1.3	1.2	1.2
Lupus	0.2	0.3	0.9	0.3	0.0	0.9
Neuroticism (2016)	14.0	20.2	24.2	-3.5	4.9	4.9
Primary Biliary Cirrhosis	0.0	0.0	0.1	-0.0	0.3	-0.2
Rheumatoid Arthritis	0.2	0.3	0.4	-0.4	0.6	0.5
Schizophrenia (2014)	1.0	2.2	3.4	1.9	-0.6	1.6
Triglycerides	0.2	0.4	0.8	0.9	-0.3	0.5
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.3	0.5	0.3	0.6
Ulcerative Colitis	1.3	2.0	4.7	2.2	-0.9	-0.6
Blood Eosinophil Count	0.2	1.6	4.2	-2.1	-0.0	-0.8
Blood Platelet Count	0.2	2.7	3.3	-1.8	1.7	1.3
Blood Red Count	0.5	4.9	12.0	0.6	-1.5	-3.5
Blood White Count	0.3	1.9	4.9	-0.4	-0.7	-2.2
Heel T-Score	0.0	0.3	0.4	0.6	-0.6	-0.5
BMI	0.3	1.5	2.7	0.0	-1.6	-1.4
Height	0.3	6.0	10.7	1.3	-2.4	-3.3
Waist Hip Ratio (WHR)	0.1	0.4	0.6	0.2	-0.7	-0.8
Systolic Blood Pressure	0.3	1.5	1.8	-1.0	1.3	1.4
Smoking Status	1.0	2.3	5.0	-2.2	1.4	0.3
Allergy or Eczema	0.1	0.3	0.7	0.8	-0.6	-0.2
Cardiovascular Disease	0.6	1.9	5.3	-2.3	-0.4	0.6
Hypothyroidism (self reported)	0.4	1.0	1.8	-0.7	1.3	0.7
Respiratory disease	0.2	0.4	0.7	0.8	-0.8	-0.1
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.2	0.1	-0.4	0.4
Lung FEV1/FVC ratio	0.1	0.3	0.5	-0.7	0.2	0.5
Lung FVC	0.5	2.3	5.7	-0.6	2.4	1.0
Neuroticism	11.2	27.0	46.8	-2.4	5.3	6.8
Chronotype (morning person)	1.2	2.8	4.5	-1.3	1.5	2.1
Hair Pigment	0.0	1.3	2.0	0.6	-1.2	-1.4
Tanning	0.0	0.3	0.9	-0.1	0.2	-1.0
Hand grip strength (left)	0.9	2.3	6.8	-0.3	-0.4	-2.6
Number of treatments/medications taken	1.1	1.9	3.8	-1.0	0.9	1.9
Average weekly spirits intake	0.6	0.7	1.5	0.7	-1.2	0.4
Sensitivity / hurt feelings	8.5	14.5	18.4	-3.3	3.8	4.3
Frequency of depressed mood in last 2 weeks	8.1	11.4	19.3	-1.7	3.5	4.4
Hearing difficulty/problems: Yes	0.7	1.0	1.9	-0.3	1.4	1.0
Relative age of first facial hair	0.0	0.0	0.1	-0.1	0.1	0.2
Other serious medical condition/disability diagnosed by doctor	1.3	1.6	2.6	-1.1	1.1	1.6
Ever used hormone-replacement therapy (HRT)	0.8	1.1	1.9	-0.4	1.1	1.4
Ever had hysterectomy (womb removed)	0.1	0.2	0.2	-0.5	0.3	-0.4
Systolic blood pressure, automated reading	0.5	1.4	2.3	-0.8	1.5	1.2
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.1	-0.1	-0.2	0.2
Angina	1.5	2.0	3.0	-1.2	1.2	1.7
Medication for hormone replacement therapy	1.0	1.1	1.6	-1.2	1.3	0.6
Vitamin and mineral supplements	1.0	1.3	2.2	-0.7	-1.1	-1.5
Supplements: Zinc	1.2	1.3	1.8	1.4	-1.3	-0.6
Medication: Co-codamol	0.5	0.6	1.3	0.6	-0.2	1.2
Medication: Metformin	0.5	0.7	2.0	0.5	-1.4	-0.2
Diabetes (father)	0.8	0.9	1.5	-0.7	1.2	0.9
Diabetes (mother)	2.0	2.6	4.4	0.7	-1.7	-2.1
Severe depression (siblings)	0.0	0.0	0.1	-0.3	0.1	0.1
Pack years adult smoking proportion	0.2	0.3	0.6	-0.3	-0.4	-0.8
Impedance of leg (right)	0.4	1.8	3.7	0.5	-1.2	-1.9
Leg fat-free mass (left)	0.0	0.2	0.3	0.0	-0.5	-0.5
Trunk fat percentage	1.1	4.4	10.6	-1.1	-1.2	-3.2
Hand grip strength (right)	0.2	0.6	1.6	-0.4	0.3	-1.3
Townsend deprivation index at recruitment	1.1	1.5	2.6	-0.8	1.6	1.1
Current tobacco smoking	1.0	1.7	2.1	-1.3	1.5	1.1
Average weekly fortified wine intake	1.4	1.7	3.0	-1.7	0.9	1.1
Maternal smoking around birth	0.0	0.1	0.2	-0.1	0.0	0.4
Fed-up feelings	4.8	8.8	13.6	-1.5	3.7	3.3
Frequency of unenthusiasm / disinterest in last 2 weeks	7.4	9.9	15.0	-1.8	3.9	3.4
Relative age voice broke	0.1	0.2	0.4	0.0	-0.6	-0.5
Taking other prescription medications	3.2	4.9	9.0	-2.0	1.3	3.0
Age when periods started (menarche)	0.1	0.3	0.4	-0.6	-0.0	0.7
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	2.9	-1.0	1.7	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.8	-0.3	0.9	0.6
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	-0.4	0.1	-0.4
Qualifications: CSEs or equivalent	1.1	1.4	2.2	0.4	-1.5	-1.4
Serious illness, injury or assault to yourself	1.2	1.4	2.0	1.1	-1.4	-1.1
High blood pressure	0.2	0.4	1.1	-1.1	0.1	0.3
Hayfever, allergic rhinitis or eczema	0.3	0.7	0.9	0.9	-1.0	-0.6
Multivitamins +/- minerals	0.5	0.6	1.4	1.2	-0.4	0.7
Stomach or abdominal pain in last month	1.0	1.3	2.3	0.7	1.0	1.5
Supplements: Glucosamine	0.2	0.2	0.3	0.5	0.4	0.5
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	1.4	0.7	-1.2	-1.1
Medication: Atenolol	0.7	0.8	1.7	-0.2	1.3	0.9
Medication: Levothyroxine sodium	1.1	1.8	2.9	-0.2	1.7	1.6
Sitting height	0.0	0.1	0.3	0.6	-0.1	-0.0
Chronic bronchitis/emphysema (father)	2.4	2.8	6.6	-0.7	-1.1	-2.6
High blood pressure (mother)	0.0	0.1	0.1	-0.0	-0.4	-0.2
Body mass index (BMI)	0.2	0.8	1.3	-1.0	-0.4	-1.1
Impedance of leg (left)	0.2	1.0	2.1	0.3	-0.9	-1.4
Leg predicted mass (left)	0.0	0.2	0.3	0.0	-0.5	-0.5
Trunk fat mass	0.8	3.6	8.3	-1.1	-1.2	-2.9
Waist circumference	0.3	1.2	2.3	-1.5	-0.1	-1.1
Number of incorrect matches in round	0.4	0.7	1.6	0.5	-0.4	-1.3
Past tobacco smoking	0.2	0.4	0.7	0.8	-0.3	0.5
Alcohol usually taken with meals	0.7	1.2	1.8	1.3	-1.4	-0.3
Nervous feelings	1.3	2.4	3.8	-0.3	1.8	1.9
Frequency of tenseness / restlessness in last 2 weeks	3.6	5.6	9.1	-1.1	3.0	2.5
Hearing difficulty/problems with background noise	4.1	6.6	8.8	-1.9	3.0	2.7
Hair/balding pattern: Pattern 2	0.6	0.8	1.6	0.7	0.5	1.3
Had menopause	0.0	0.1	0.1	0.2	0.3	-0.0
Had other major operations	0.1	0.2	0.3	-0.4	0.0	-0.5
Forced vital capacity (FVC)	0.2	0.6	1.4	-0.1	1.2	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.2	-0.2	0.1	-0.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.1	-0.2	0.4	-0.2
Qualifications: None of the above	0.8	1.6	3.3	-1.8	1.3	0.1
Financial difficulties in last 2 years	0.9	1.2	2.5	-0.3	1.0	1.6
Mouth/teeth dental problems	1.9	2.9	4.7	0.8	-2.2	-1.8
Heart attack	0.2	0.2	0.5	-0.7	0.4	-0.0
Allergy	0.1	0.2	0.3	-0.1	0.6	0.5
Pain all over the body in last month	1.8	1.9	2.3	-1.4	1.5	1.2
Diabetes (self-reported)	0.1	0.2	0.5	-0.2	-0.3	0.7
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.5	-0.7	0.3	0.7
Medication: Ramipril	1.0	1.3	2.1	-1.5	1.4	0.0
Medication: Simvastatin	0.3	0.5	0.9	-0.8	-0.1	0.9
Fluid intelligence score	0.6	1.2	2.6	1.0	-0.3	1.6
Illnesses of siblings	0.1	0.2	0.5	-0.1	0.7	0.1
Neuroticism score	4.9	10.2	18.0	-1.1	3.3	4.2
Weight	0.3	1.4	3.0	-0.5	-0.9	-1.7
Impedance of arm (right)	1.6	7.6	15.8	1.4	-2.3	-4.0
Arm fat percentage (right)	1.3	5.1	12.2	-0.8	-1.6	-3.5
Trunk fat-free mass	0.0	0.2	0.4	0.2	-0.6	0.2
Hip circumference	0.1	0.5	0.8	-0.9	-0.2	-0.7
Time employed in main current job	0.3	0.3	0.6	0.6	-0.7	-0.1
Alcohol intake versus 10 years previously	0.1	0.1	0.2	-0.3	0.4	-0.3
Father’s age at death	0.0	0.1	0.1	-0.1	0.3	0.2
Worrier / anxious feelings	3.2	6.1	9.1	-1.4	2.7	3.0
Frequency of tiredness / lethargy in last 2 weeks	6.0	9.7	15.4	-1.4	3.9	3.4
Falls in the last year	0.1	0.2	0.3	-0.2	0.5	0.5
Hair/balding pattern: Pattern 3	1.4	2.0	3.2	-1.0	1.8	1.4
Number of live births	1.0	1.4	2.4	-0.7	-1.1	-1.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.6	-0.6	1.3	-0.5
Pulse rate	0.0	0.1	0.2	0.2	-0.4	-0.1
Happiness	0.2	0.2	0.4	0.4	-0.6	-0.2
Noisy workplace	0.4	0.5	1.0	-0.7	1.0	0.3
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.2	0.5	-0.2	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	3.1	-1.8	0.1	-0.2
Mouth/teeth dental problems: Dentures	3.1	5.2	7.7	-2.1	2.8	1.8
Asthma	0.1	0.2	0.5	0.2	-0.7	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.2	0.6	-0.6	-1.1
Medication: Cholesterol lowering	0.1	0.1	0.2	-0.2	-0.1	0.4
Depression (self-reported)	0.9	1.1	2.1	-0.7	0.8	1.5
Medication: Lansoprazole	0.0	0.0	0.1	0.1	-0.3	-0.2
Prospective memory result	0.0	0.0	0.0	-0.1	0.2	-0.1
Lung cancer (father)	2.1	2.4	3.5	-1.9	1.8	0.8
Illnesses of mother	0.2	0.3	0.8	-0.2	0.1	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.8	-0.4	0.9	-0.2
Pulse wave Arterial Stiffness index	2.8	3.3	6.7	-0.7	1.7	2.6
Impedance of arm (left)	1.5	7.1	15.5	1.1	-2.2	-3.9
Arm fat mass (right)	0.6	2.6	5.8	-0.6	-1.2	-2.4
Trunk predicted mass	0.0	0.2	0.4	0.2	-0.6	0.2
Standing height	0.2	2.2	2.9	1.1	-1.6	-1.7
Length of working week for main job	0.7	0.8	2.0	-0.2	1.4	0.6
Exposure to tobacco smoke at home	0.4	0.5	1.1	-1.0	0.3	-0.5
Breastfed as a baby	0.9	1.1	2.7	0.7	-1.6	-0.0
Tense / ‘highly strung’	0.6	1.0	1.7	-0.6	0.9	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.7	10.3	0.0	0.9	3.2
Hair/balding pattern: Pattern 4	1.1	2.6	3.4	-1.8	1.5	1.4
Birth weight of first child	0.2	0.3	0.5	-0.6	-0.5	-0.7
Peak expiratory flow (PEF)	0.6	1.5	3.2	-1.8	0.8	-0.8
Pulse wave reflection index	0.7	0.9	1.8	-0.3	0.9	1.3
Ever highly irritable/argumentative for 2 days	0.5	0.5	0.9	0.6	0.9	0.7
Loud music exposure frequency	0.6	0.6	1.6	-0.3	1.3	-0.4
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.7	1.3	-0.8	-0.6
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	1.8	-0.3	1.1	1.4
Blood clot in the leg (DVT)	0.2	0.2	0.6	-0.8	0.3	-0.1
Medication: Paracetamol	0.7	1.1	2.6	-1.6	-0.0	-0.9
Headache pain in last month	0.1	0.3	0.3	0.6	0.5	0.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.5	0.7	-0.0	-0.7
Glaucoma (self-reported)	0.3	0.4	1.1	0.2	0.2	1.1
Gout (self-reported)	2.0	2.8	5.0	-0.5	2.2	1.8
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	1.7	-0.2	1.3	1.1
Medication: Amlodipine	0.4	0.5	1.5	0.2	-1.2	-0.3
Medication: Ventolin 100micrograms inhaler	0.3	0.3	0.9	0.3	-0.0	1.0
Birth weight	1.0	2.1	3.6	0.3	-1.6	-1.9
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.3	-0.6	0.5	0.5
High blood pressure (siblings)	0.7	1.1	1.9	0.6	-1.0	-1.4
Forced vital capacity (FVC), Best measure	0.1	0.3	0.6	-0.3	0.8	-0.4
Body fat percentage	1.1	4.3	9.8	-1.4	-1.1	-3.1
Leg fat percentage (right)	0.8	3.0	6.0	-1.6	-0.6	-2.5
Arm fat-free mass (right)	0.1	0.6	1.2	-0.6	0.3	1.1
Exposure to tobacco smoke outside home	3.8	5.1	5.3	-2.3	2.3	2.2
Comparative body size at age 10	0.8	2.1	2.4	1.6	-1.5	-1.3
Number of full brothers	0.3	0.4	0.7	0.1	0.8	0.7
Worry too long after embarrassment	3.5	5.9	11.7	-0.2	2.5	3.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.1	-0.1	0.5
Wheeze or whistling in the chest in last year	0.2	0.3	0.4	-0.6	0.6	0.5
Number of children fathered	0.7	0.8	1.6	-1.3	0.9	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	0.8	0.6	-0.8	0.9
Age at first live birth	3.0	5.3	8.9	2.5	-3.0	-0.8
Pulse wave peak to peak time	2.9	3.5	7.0	0.7	-1.7	-2.6
Health satisfaction	0.1	0.1	0.1	0.3	-0.2	0.2
Shortness of breath walking on level ground	2.2	2.6	4.0	-1.0	2.0	1.7
Qualifications: College or University degree	0.5	1.5	3.2	1.1	-1.8	-0.3
Eye problems/disorders: None of the above	1.1	1.2	3.0	-0.1	1.7	0.8
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	0.4	0.4	-0.1
Emphysema/chronic bronchitis	0.9	1.0	1.7	-0.4	1.3	1.0
Medication for pain relief, constipation, heartburn	0.4	0.8	1.3	1.2	0.4	0.9
Neck or shoulder pain in last month	1.1	1.6	2.6	-0.1	1.5	1.6
Medication: Blood pressure	0.4	0.7	1.7	-1.3	0.6	0.2
Angina (self-reported)	1.3	1.7	2.7	-1.0	1.1	1.6
Migraine (self-reported)	5.7	7.0	9.6	2.7	-3.1	-2.1
Medication: Ibuprofen	0.0	0.0	0.1	0.2	0.2	-0.1
Medication: Allopurinol	0.3	0.4	0.9	0.2	0.9	0.6
Medication: Omeprazole	1.1	1.4	3.1	-1.0	0.2	1.8
Medication: Seretide 50 evohaler	0.0	0.0	0.1	0.2	-0.0	0.3
Mean time to correctly identify matches	1.7	3.2	5.2	-1.5	1.4	2.3
Heart disease (mother)	0.2	0.2	0.4	0.4	-0.1	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.3	0.6	0.1	0.6
Whole body fat mass	0.7	3.0	6.6	-1.1	-1.1	-2.6
Leg fat mass (right)	0.6	2.2	4.5	-1.3	-0.6	-2.1
Arm predicted mass (right)	0.1	0.5	0.9	-0.7	0.3	1.0
Pulse rate, automated reading	0.1	0.3	0.7	0.4	-0.8	-0.1
Alcohol intake frequency.	0.1	0.3	0.4	-0.4	-0.5	-0.6
Comparative height size at age 10	0.5	2.6	6.1	-0.1	-1.3	-2.5
Number of full sisters	0.4	0.5	1.3	0.3	0.5	1.1
Suffer from ‘nerves’	4.2	6.7	9.2	-1.7	2.8	3.0
Overall health rating	2.3	5.0	6.7	-1.4	2.6	2.5
Chest pain or discomfort	3.1	4.5	8.2	-0.3	2.3	2.9
Had major operations	1.7	2.0	4.3	0.0	-1.2	-2.1
Age at last live birth	2.6	3.8	6.7	1.9	-2.6	-1.1
Family relationship satisfaction	0.7	0.9	1.1	-1.0	0.8	1.1
Leg pain on walking	0.3	0.3	0.5	-0.7	0.4	-0.6
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	3.5	1.9	-0.4	-0.0
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.3	-0.8	1.1	0.7
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.1	1.0	-0.1	-0.0
Medication: Aspirin	0.2	0.2	0.4	-0.6	0.1	-0.6
Supplements: Vitamin C	0.3	0.4	0.8	0.9	0.5	0.5
Knee pain experienced in last month	2.3	3.6	5.8	-1.9	2.4	1.1
Hypertension (Self-reported)	0.2	0.6	1.7	-1.3	0.1	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.4	-0.0	-0.3	0.6
Illnesses of father: Heart disease	2.9	4.0	6.0	1.9	-2.5	-1.4
Illnesses of siblings: Diabetes	0.3	0.3	0.5	0.7	-0.4	0.5
Smoking status: Previous	0.2	0.3	0.6	-0.8	0.2	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.1	1.0	-0.6	0.2
Whole body fat-free mass	0.0	0.1	0.2	0.1	-0.5	0.1
Leg fat-free mass (right)	0.0	0.0	0.0	0.0	-0.2	-0.1
Arm fat percentage (left)	1.1	4.5	10.6	-1.1	-1.3	-3.2
Average weekly red wine intake	1.3	1.9	2.8	1.7	-1.7	-0.4
Handedness (chirality/laterality): Left-handed	1.2	1.5	1.9	0.9	-1.3	-1.4
Mood swings	2.2	4.0	8.1	-0.1	2.0	2.9
Loneliness, isolation	8.7	12.1	17.6	-2.2	3.7	4.2
Long-standing illness, disability or infirmity	1.2	1.9	2.0	-1.4	1.4	1.3
Ever had bowel cancer screening	0.5	0.6	0.9	-0.9	0.4	-0.9
Diabetes diagnosed by doctor	0.0	0.1	0.1	-0.3	-0.3	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.0	0.1	-0.0	-0.1
Friendships satisfaction	0.6	0.8	1.3	-0.4	0.9	1.2
Qualifications: nursing, teaching	1.5	2.4	5.0	1.0	-2.2	-1.1
Commuting to job workplace: Walk	0.2	0.2	0.5	-0.4	-0.1	-0.7
Eye problems/disorders: Cataract	0.9	1.1	1.7	1.2	-1.3	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.7	0.8	-0.5	-0.6
Medication for cholesterol	0.6	0.9	1.5	1.2	0.4	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.5	0.7	-0.7	0.2
Back pain experienced in last month	0.4	0.5	0.8	0.3	0.9	0.9
Mineral and other dietary supplements	0.8	1.1	2.6	-1.6	0.8	0.4
Breast cancer (self-reported)	1.5	1.8	3.7	-1.9	1.3	-0.2
Asthma (self-reported)	0.1	0.2	0.6	0.4	-0.8	0.0
Osteoporosis (self-reported)	2.4	3.0	5.9	2.4	-1.4	-1.1
Osteoarthritis (self-reported)	0.3	0.4	0.6	-0.7	0.8	0.4
Medication: Aspirin	0.3	0.4	1.0	-1.0	0.4	-0.1
Medication: Gliclazide	0.2	0.3	0.3	0.5	-0.6	0.5
Illnesses of father: None of the above (group 1)	1.4	1.7	3.8	-0.1	1.1	2.0
Smoking status: Current	0.5	0.8	1.1	-1.0	1.0	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	2.0	-1.1	1.4	0.7
Whole body water mass	0.0	0.1	0.2	0.1	-0.4	0.2
Leg predicted mass (right)	0.0	0.0	0.0	-0.1	-0.2	-0.1
Arm fat mass (left)	0.6	2.6	6.0	-0.9	-1.1	-2.4
Number of self-reported non-cancer illnesses	0.9	1.5	3.8	-0.5	0.7	2.0
Average weekly champagne plus white wine intake	0.2	0.3	0.7	-0.2	0.3	0.8
Miserableness	1.7	2.9	4.6	-0.5	2.0	2.2
Guilty feelings	7.2	10.9	14.3	-2.7	3.8	3.4
Wears glasses or contact lenses	0.6	0.7	1.2	-1.1	0.4	-0.9
Ever taken oral contraceptive pill	0.1	0.1	0.2	-0.1	-0.4	-0.4
Hearing aid user	0.7	0.8	1.4	1.2	-0.6	0.9
Mother’s age at death	1.2	1.6	2.3	-0.1	-1.5	-1.5
Financial situation satisfaction	1.8	2.3	2.9	1.6	-1.1	-1.7
Tinnitus: Yes, now most or all of the time	2.3	2.7	4.1	-0.9	2.0	1.8
Commuting to job workplace: Public transport	3.0	3.6	4.5	1.7	-2.1	-1.8
Eye problems/disorders: Glaucoma	0.7	0.8	2.0	-1.4	0.4	0.5
Medication: Blood pressure	0.2	0.3	0.7	-0.9	0.1	0.4
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.5	0.1	0.7	0.7
Supplements: Fish oil (including cod liver oil)	1.5	2.0	3.0	1.7	-1.5	-0.8
High cholesterol (Self-reported)	0.4	0.8	1.2	-1.0	-0.2	1.1
Medication: Bendroflumethiazide	0.0	0.1	0.2	0.1	-0.4	0.2
Medication: Paracetamol	0.4	0.6	1.4	-1.2	0.2	-0.5
Medication: Lisinopril	1.5	1.9	4.9	-2.2	0.1	-1.0
Medication: Atorvastatin	0.6	0.7	1.0	-0.6	0.8	1.0
Illnesses of father: High blood pressure	0.3	0.4	0.8	-0.9	0.6	-0.2
Alcohol drinker status: Never	0.0	0.1	0.2	-0.4	-0.1	-0.1
Ever smoked	0.6	1.0	1.9	-1.4	0.7	-0.8
Basal metabolic rate	0.0	0.2	0.4	-0.1	-0.6	-0.4
Leg fat percentage (left)	0.6	2.3	4.0	-1.7	-0.3	-2.0
Arm fat-free mass (left)	0.0	0.2	0.5	-0.4	0.0	0.7
Number of operations (self-reported)	1.3	1.9	3.0	-1.7	1.6	0.2
Average weekly beer plus cider intake	1.1	1.6	2.5	-1.0	1.6	1.1
Irritability	2.5	4.2	8.4	-0.5	2.0	2.9
Risk taking	0.7	1.0	2.0	1.4	-0.7	-0.7
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.3	-0.5	0.3	-0.5
Fractured/broken bones in last 5 years	1.2	1.5	3.0	1.0	0.7	1.7
Age started oral contraceptive pill	1.6	2.0	2.8	1.0	-1.7	-1.5
Diastolic blood pressure, automated reading	1.2	3.8	5.1	-2.1	2.2	1.4
Ever depressed for a whole week	1.3	1.6	2.7	0.9	1.2	1.7
Unable to work because of sickness or disability	1.2	1.5	2.2	-1.4	0.7	1.5
Commuting to job workplace: Cycle	0.6	0.7	1.5	1.2	0.2	0.9
Myopia	0.2	0.3	0.5	0.7	0.6	0.2
Vascular/heart problems diagnosed by doctor	0.7	1.8	3.5	1.9	-0.9	-1.0
Cholesterol lowering medication	0.4	0.6	1.5	-0.2	-0.3	1.2
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	2.4	-1.5	0.5	1.5
Pain experienced in last month	1.9	3.2	4.9	1.6	-2.2	-1.4
Supplements: Calcium	0.8	0.8	2.2	1.5	-0.5	0.2
Basal cell carcinoma (self-reported)	0.5	0.6	1.0	1.0	-0.8	-0.5
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.5	-1.2	0.8	0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.4	-0.7	0.3	-0.1
Heart disease (siblings)	2.8	3.4	4.1	-2.0	1.8	1.8
Alcohol drinker status: Previous	1.9	2.2	5.0	-2.2	0.8	0.9
Pack years of smoking	0.3	0.4	0.7	-0.7	-0.1	-0.9
Impedance of whole body	0.7	3.6	8.0	0.6	-1.5	-2.8
Leg fat mass (left)	0.4	1.7	3.2	-1.3	-0.4	-1.8
Arm predicted mass (left)	0.0	0.2	0.5	-0.3	0.0	0.7