TWAS hub - MAP1LC3B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1948	0.0587	8.7e-05	0.013	NA	0.027	NA	0.018	2.9e-02	NA	3.0e-03	NA	1.3e-02
2	METSIM	Adipose	0.0873	0.0261	2.6e-06	0.071	0.031	0.060	0.055	0.056	7.1e-11	1.9e-05	2.1e-09	1.0e-08	8.5e-09
3	NTR	Blood	0.0476	0.0149	4.4e-05	0.015	0.017	0.029	0.031	0.032	8.7e-06	2.9e-06	9.8e-10	2.1e-10	1.6e-10
4	YFS	Blood	0.1491	0.0225	0.0e+00	0.076	0.114	0.102	0.100	0.098	9.2e-24	4.0e-35	1.1e-31	4.2e-31	2.6e-30
5	TCGA	Breast Invasive Carcinoma	0.0258	0.0128	5.2e-04	0.001	0.012	0.002	NA	0.000	1.4e-01	1.3e-03	1.2e-01	NA	2.6e-01
6	TCGA	Brain Lower Grade Glioma	0.0466	0.0249	4.6e-03	0.030	0.007	0.021	NA	0.026	2.0e-04	4.3e-02	1.6e-03	NA	5.6e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Mood swings	9.7	17.6	28.8	-4.4	-4.3	-5.4	-5.0	-3.7	0.8
Neuroticism	8.3	20.1	31.1	-4.9	-5.2	-5.6	-4.6	-4.1	0.3
Mean time to correctly identify matches	7.4	14.1	22.1	-4.4	-4.7	-3.5	-3.8	-4.1	0.4
Neuroticism score	7.1	14.8	22.0	-4.7	-4.2	-4.6	-4.2	-3.2	0.5
Neuroticism (Nagel 2018)	6.9	16.1	25.4	-4.3	-4.8	-5.0	-3.8	-3.7	1.2
Reaction Time	6.1	11.6	16.6	-4.0	-4.1	-3.2	-3.8	-3.5	-0.0
Smoking Status	5.8	13.8	22.2	-3.5	-4.7	-4.3	-3.1	-4.4	0.8
Worry (Nagel 2018)	5.1	10.8	17.4	-4.0	-4.0	-4.2	-2.7	-2.2	1.8
Verbal and Numeric Reasoning (VNR)	4.7	11.2	19.1	3.1	4.1	4.4	2.8	3.6	0.4
Sensitivity / hurt feelings	4.5	7.7	13.9	-2.4	-3.7	-3.7	-2.8	-1.9	1.1
Depressed Affect (Nagel 2018)	4.2	8.8	12.3	-3.0	-3.1	-3.5	-3.2	-3.3	0.2
Intelligence (Savage-Jansen 2018)	4.2	13.0	22.2	3.6	4.3	4.7	3.5	3.4	-0.6
Guilty feelings	4.1	6.2	11.6	-3.4	-2.5	-2.7	-2.6	-2.2	-0.2
Prospective memory result	4.0	4.9	10.3	-3.2	-2.8	-2.0	-1.1	-1.5	2.0
Number of incorrect matches in round	3.8	6.3	10.2	-1.6	-3.0	-3.2	-2.8	-2.9	0.3
Nervous feelings	3.6	6.7	12.5	-3.2	-3.3	-3.5	-2.0	-1.4	0.8
Smoking status: Current	3.6	5.7	9.9	-2.4	-3.1	-2.6	-1.4	-3.1	0.2
Current tobacco smoking	3.5	5.8	11.1	-2.3	-3.3	-2.7	-1.5	-2.9	0.3
Peak expiratory flow (PEF)	3.4	7.9	14.8	3.8	3.9	2.9	2.1	1.8	-1.5
Suffer from ‘nerves’	3.3	5.2	14.6	-2.5	-2.5	-3.8	-1.7	-1.3	0.0
Heart attack	3.2	4.1	10.3	0.4	-1.4	-1.6	-2.1	-2.4	-3.2
Medication: Ibuprofen (e.g. Nurofen)	3.2	4.1	6.5	-2.6	-2.2	-2.5	-2.2	-1.3	-0.3
Qualifications: College or University degree	3.2	10.0	21.9	2.8	4.7	3.5	2.7	2.7	-1.8
Qualifications: A levels/AS levels or equivalent	2.9	6.4	9.7	2.2	3.1	3.0	2.7	2.7	-0.2
Hair/balding pattern: Pattern 3	2.8	4.1	10.7	-1.7	-3.3	-2.6	-0.4	-1.9	-0.1
Heart attack/myocardial infarction (self-reported)	2.8	3.6	9.6	0.5	-1.1	-1.3	-1.9	-2.3	-3.1
Worrier / anxious feelings	2.7	5.1	9.9	-3.1	-3.0	-2.2	-1.7	-1.5	1.2
Alzheimer’s Disease (in father)	2.6	2.9	4.5	1.7	1.1	1.7	1.7	1.8	2.1
Ever had hysterectomy (womb removed)	2.6	3.0	6.8	0.7	1.0	2.0	2.3	2.6	0.7
Frequency of tenseness / restlessness in last 2 weeks	2.6	4.1	7.6	-2.8	-2.2	-1.9	-1.5	-0.8	2.5
Birth weight	2.6	5.7	11.5	2.5	2.6	2.0	3.4	2.3	0.1
Osteoporosis (self-reported)	2.5	3.1	8.8	3.0	1.4	0.9	1.8	0.6	-1.8
Diastolic blood pressure, automated reading	2.5	7.7	12.8	2.0	3.6	3.5	2.8	3.1	0.0
Neuroticism (2016)	2.4	3.4	5.7	-2.0	-2.4	-2.1	-1.6	-1.3	1.5
Frequency of depressed mood in last 2 weeks	2.4	3.3	7.8	-2.8	-1.6	-1.8	-1.4	-2.0	0.5
Osteoarthritis (self-reported)	2.4	3.1	6.9	0.0	-2.6	-2.0	-2.3	-1.6	0.3
Tense / ‘highly strung’	2.3	3.8	8.5	-2.0	-2.2	-2.9	-2.0	-0.3	1.0
Exposure to tobacco smoke outside home	2.3	3.1	9.8	-3.1	-2.2	-0.6	-1.1	-1.5	0.5
Alcohol drinker status: Never	2.3	2.7	6.7	0.5	1.8	2.0	0.6	2.6	1.4
Irritability	2.3	3.8	6.3	-1.7	-2.5	-1.8	-2.4	-1.2	1.8
Relative age of first facial hair	2.2	4.6	9.8	1.8	3.1	3.0	1.5	1.8	-0.5
Pack years of smoking	2.2	3.3	6.0	-1.5	-2.4	-1.8	-1.8	-2.2	-0.4
Bipolar Disorder (2018)	2.1	3.3	7.7	-1.6	-2.4	-2.8	-0.7	-0.6	1.6
Taking other prescription medications	2.1	3.2	6.1	0.7	2.5	2.3	1.9	1.7	0.7
Had other major operations	2.1	2.5	7.6	0.7	1.5	2.8	1.3	1.4	1.2
Shortness of breath walking on level ground	2.1	2.6	6.6	-0.7	-1.9	-2.6	-1.6	-1.3	-0.7
Supplements: Calcium	2.1	2.4	4.4	2.1	1.6	0.8	1.8	0.4	-1.7
Medication for hormone replacement therapy	2.0	2.2	3.9	-1.6	-2.0	-1.7	-1.3	-1.4	-0.4
Tinnitus: Yes, but not now, but have in the past	2.0	2.1	5.2	2.3	1.8	-0.4	0.9	0.7	-1.6
Hair/balding pattern: Pattern 4	2.0	4.7	9.5	-0.6	-1.0	-2.4	-2.3	-3.1	-2.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.4	5.7	0.1	-0.3	-2.4	-1.4	-1.7	-1.8
Schizophrenia (2014)	1.9	4.2	9.9	-2.2	-2.4	-3.1	-1.6	-0.7	1.3
Sitting height	1.9	13.1	29.3	4.2	5.4	3.7	2.2	3.1	-1.9
Wheeze or whistling in the chest in last year	1.9	3.3	7.7	-2.8	-1.5	-1.5	-2.2	-1.5	1.0
Ever had prostate specific antigen (PSA) test	1.9	2.2	6.8	-1.2	-1.2	-1.2	-2.6	-1.4	-0.4
Depression (Nagel 2018)	1.8	2.8	4.6	-2.1	-1.8	-1.7	-0.8	-1.2	1.9
Medication: Lansoprazole	1.8	2.0	4.4	2.1	0.8	0.6	0.9	1.9	1.4
Eye problems/disorders: Glaucoma	1.8	2.1	9.1	0.7	1.6	0.2	-0.3	-0.4	-3.0
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	4.2	-1.5	-1.2	-1.6	-0.6	-2.0	-0.9
Stomach or abdominal pain in last month	1.7	2.1	4.6	1.6	1.3	0.4	1.9	2.1	0.7
Past tobacco smoking	1.7	3.2	5.5	1.7	2.3	2.0	2.0	1.0	-1.4
Hearing difficulty/problems with background noise	1.7	2.8	9.0	0.9	1.4	-0.1	-2.0	-0.8	-3.0
Breastfed as a baby	1.7	2.1	5.2	1.2	0.9	1.5	2.3	1.6	0.6
Glaucoma (self-reported)	1.7	2.0	6.4	0.4	1.9	0.9	1.0	0.0	-2.5
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	6.9	-2.4	-0.5	0.2	-0.2	-0.4	2.6
HDL Cholesterol	1.6	2.7	6.5	-1.0	-1.6	-1.6	-2.5	-1.8	-0.4
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	3.7	0.3	0.6	1.7	1.9	1.8	1.5
Qualifications: None of the above	1.6	3.4	6.2	-1.2	-2.1	-2.2	-2.5	-1.7	0.8
Noisy workplace	1.6	2.0	4.1	-1.7	-1.6	-2.0	0.5	-1.0	1.0
Qualifications: nursing, teaching	1.6	2.5	6.3	1.0	2.1	1.5	2.5	1.2	-0.3
Miserableness	1.6	2.8	5.6	-1.3	-0.8	-1.8	-2.4	-1.6	-1.9
Financial situation satisfaction	1.6	1.9	4.3	-1.7	-1.7	-0.4	0.1	1.2	2.1
Trunk fat percentage	1.5	5.9	12.7	1.9	3.6	3.4	1.9	1.4	-1.6
Ever smoked	1.5	2.7	4.9	-1.9	-2.2	-1.8	-1.6	-1.0	0.5
Bipolar Disorder or Schizophrenia	1.4	3.4	9.5	-1.9	-2.2	-3.1	-0.8	-0.3	1.3
Diabetes (father)	1.4	1.7	6.5	0.4	1.4	2.6	0.6	1.0	0.6
Severe depression (siblings)	1.4	1.6	3.9	-1.6	-2.0	-1.6	-0.4	-0.6	0.5
Pack years adult smoking proportion	1.4	2.1	4.4	-1.1	-2.1	-1.3	-1.2	-1.9	-0.3
Maternal smoking around birth	1.4	2.0	4.7	-0.6	-2.2	-1.9	-0.4	-1.2	1.3
High blood pressure (mother)	1.4	2.0	3.5	0.6	1.9	1.7	1.4	1.7	0.6
Hip circumference	1.4	5.9	16.1	1.0	4.0	3.5	1.0	2.0	-0.8
Ever highly irritable/argumentative for 2 days	1.4	1.7	3.8	-1.0	-1.5	-1.5	-1.9	-0.1	1.1
Blood clot in the leg (DVT)	1.4	1.9	6.4	-2.2	-0.2	0.2	-0.1	-0.2	2.5
Worry too long after embarrassment	1.4	2.3	4.5	-1.5	-1.9	-2.1	-1.5	-1.2	0.2
Mouth/teeth dental problems: Loose teeth	1.4	1.7	3.1	-1.6	-1.8	-1.7	-1.1	-0.6	0.6
Schizophrenia vs Biploar Disorder	1.3	1.7	4.2	-1.9	-0.9	-0.3	-2.1	-1.2	0.4
Major Depression (MDD)	1.3	1.6	6.9	-1.2	-0.7	-0.4	0.5	0.4	2.6
Type 2 Diabetes (T2D) (2012)	1.3	1.5	2.7	1.6	1.0	1.0	1.4	1.4	-0.5
Townsend deprivation index at recruitment	1.3	1.8	3.5	1.9	1.2	1.7	1.3	1.1	-0.6
Trunk fat mass	1.3	5.6	13.3	1.9	3.6	3.1	1.6	1.5	-1.6
Medication: Cholesterol lowering	1.3	2.0	5.3	-1.2	-0.6	-1.0	-0.5	-2.3	-1.8
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	4.7	1.4	1.8	2.2	1.0	1.2	-0.3
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	4.6	2.1	0.9	0.9	1.2	2.1	1.0
Ever had bowel cancer screening	1.3	1.5	6.0	2.5	0.4	0.3	0.8	1.1	0.8
Pain experienced in last month	1.3	2.1	4.2	1.8	1.3	1.6	2.0	1.0	-0.6
Ovarian Cancer	1.2	1.6	5.4	0.1	1.1	1.2	2.3	1.1	0.7
Diverticular disease/diverticulitis (self-reported)	1.2	1.5	3.2	1.1	1.8	1.4	0.5	1.4	-0.4
Chronic bronchitis/emphysema (father)	1.2	1.4	3.1	-1.8	-0.6	-1.0	-1.2	-0.0	1.6
Forced expiratory volume in 1-second (FEV1)	1.2	3.9	9.0	3.0	2.4	1.6	1.5	2.0	0.1
Body fat percentage	1.2	4.7	10.3	1.5	3.1	3.2	1.8	1.3	-1.2
Medication: Blood pressure	1.2	2.0	3.9	-2.0	-0.3	-0.8	-1.4	-1.7	-1.7
Illnesses of siblings: Diabetes	1.2	1.4	4.3	0.5	1.7	0.0	-0.9	-0.5	-2.1
Medication: Blood pressure	1.2	2.3	6.6	0.7	0.8	2.6	1.4	2.0	0.1
Illnesses of father: High blood pressure	1.2	1.4	2.7	-1.6	-1.3	-0.7	-0.9	-1.6	-0.7
Age started oral contraceptive pill	1.2	1.5	6.0	1.3	-0.1	-0.2	-0.3	-1.0	-2.4
Supplements: Zinc	1.1	1.2	2.9	-1.0	-0.6	-1.7	-1.0	-1.3	0.5
Diabetes (self-reported)	1.1	1.7	4.8	-1.6	0.2	-0.2	-0.3	-2.2	-1.6
Medication: Simvastatin	1.1	1.6	5.7	-0.7	0.8	0.5	-0.4	-1.5	-2.4
Medication: Ibuprofen	1.1	1.4	3.0	-1.4	-1.1	-1.2	-1.7	-0.5	-0.5
Mineral and other dietary supplements	1.1	1.5	3.5	-1.9	-1.5	-0.9	-0.9	-1.1	0.8
Medication: Gliclazide	1.1	1.3	2.7	-0.6	0.9	1.7	1.5	0.9	0.7
Mother’s age at death	1.1	1.4	5.3	0.4	-0.1	-1.5	0.6	-0.6	-2.3
High cholesterol (Self-reported)	1.1	1.9	7.3	0.4	0.4	0.1	0.5	-1.8	-2.7
Commuting to job workplace: Cycle	1.1	1.3	5.3	0.2	1.4	0.8	0.1	-0.4	-2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	3.0	-1.4	-0.9	-1.4	-0.5	-0.2	1.7
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	3.5	-1.9	-1.7	-1.3	-1.5	-1.7	0.2
Eye problems/disorders: None of the above	1.0	1.2	4.3	2.1	-0.9	-0.4	0.1	0.8	1.0
Had major operations	1.0	1.2	3.3	-0.2	0.0	-0.9	-0.7	-1.6	-1.8
Medication: Atorvastatin	1.0	1.2	2.6	0.0	-1.6	-1.3	-1.0	-1.1	-0.9
Number of operations (self-reported)	1.0	1.6	3.5	-0.7	1.1	1.9	1.7	0.6	1.0
Blood White Count	0.9	6.8	16.1	-4.0	-1.2	-1.6	-1.9	-3.9	-1.5
Tanning	0.9	11.2	23.0	-1.7	-4.8	-4.6	-3.1	-2.8	1.6
Ever used hormone-replacement therapy (HRT)	0.9	1.1	4.0	-2.0	-1.1	0.2	-0.5	0.1	1.2
Fed-up feelings	0.9	1.7	6.3	-2.5	-0.7	0.1	-1.3	-0.5	1.2
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.7	-0.1	0.8	1.0	1.6	1.2	0.3
Fluid intelligence score	0.9	1.9	3.6	1.8	1.9	1.8	0.6	1.2	-0.2
Gout (self-reported)	0.9	1.2	3.3	1.0	1.0	1.1	1.8	0.9	0.3
Number of children fathered	0.9	1.0	3.1	-1.5	-0.4	0.3	1.8	-0.3	0.3
Neck or shoulder pain in last month	0.9	1.3	3.6	-0.2	-0.9	-1.1	-1.9	-1.4	0.3
Whole body fat mass	0.9	3.7	9.1	1.3	3.0	2.7	1.2	1.2	-1.2
Illnesses of father: None of the above (group 1)	0.9	1.1	2.7	1.5	0.5	0.0	1.0	1.6	-0.5
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.3	-1.5	-1.2	-1.0	-0.8	-1.0	0.3
Risk taking	0.9	1.3	3.0	1.5	1.7	-0.3	0.8	-0.1	-1.3
Leg fat mass (left)	0.9	3.4	7.9	1.0	2.8	2.8	1.2	1.4	-0.8
Rheumatoid Arthritis	0.8	1.1	1.8	-1.3	-0.6	-1.3	-0.7	-0.9	-1.3
Hair Pigment	0.8	22.1	43.7	3.5	5.0	5.1	6.6	5.0	1.0
Diabetes (mother)	0.8	1.0	2.2	-0.8	-0.2	-0.9	-1.4	-1.5	-0.5
Supplements: Glucosamine	0.8	1.0	3.9	2.0	0.6	0.9	0.3	1.1	0.2
Pain all over the body in last month	0.8	0.9	3.7	-0.7	-0.2	-0.7	-0.4	-1.9	-0.5
Illnesses of siblings	0.8	1.1	4.0	0.9	-0.1	0.6	-0.1	2.0	1.3
Weight	0.8	3.9	10.2	1.6	3.2	2.5	1.0	1.7	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.7	6.5	2.5	1.8	1.1	1.4	1.7	-0.1
Impedance of arm (left)	0.8	3.7	7.0	2.1	2.0	1.7	2.6	0.6	-1.9
Number of full brothers	0.8	1.0	3.3	1.1	1.8	0.8	0.7	0.5	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.5	-1.0	-1.6	-0.9	-0.4	-0.8	0.6
Leg fat mass (right)	0.8	3.0	7.1	0.9	2.5	2.7	1.1	1.5	-0.6
Number of full sisters	0.8	1.0	3.1	1.3	1.8	0.2	0.8	0.2	-0.8
Knee pain experienced in last month	0.8	1.2	4.2	-0.7	-2.0	-0.9	-1.1	-0.3	0.6
Smoking status: Previous	0.8	1.2	2.0	-0.8	-1.4	-1.2	-1.1	0.1	1.4
Arm fat percentage (left)	0.8	3.1	7.4	0.8	2.7	2.5	1.5	1.2	-0.8
Loneliness, isolation	0.8	1.1	2.9	-1.5	0.1	-1.1	-0.3	-1.7	-0.7
Long-standing illness, disability or infirmity	0.8	1.2	1.9	-1.4	0.6	1.1	1.2	0.9	1.3
Diabetes diagnosed by doctor	0.8	1.2	3.3	-1.2	0.1	-0.3	-0.3	-1.8	-1.5
Number of self-reported non-cancer illnesses	0.8	1.4	4.1	-0.1	2.0	0.8	0.8	-0.1	-1.7
Supplements: Fish oil (including cod liver oil)	0.8	1.0	1.5	1.2	1.0	1.2	1.0	1.0	-0.0
Cholesterol lowering medication	0.8	1.2	4.5	0.4	-0.3	0.6	-0.8	-1.1	-2.1
Age at First Birth	0.7	1.0	2.1	1.3	-0.5	-1.5	0.5	-0.5	-1.1
Coronary Artery Disease (CAD)	0.7	0.8	2.2	-1.1	-1.1	0.0	0.1	0.3	1.5
Crohns Disease (2012)	0.7	1.1	4.3	-0.5	-1.4	-0.0	0.1	-0.6	2.1
Primary Biliary Cirrhosis	0.7	1.0	2.5	-0.8	-0.8	0.0	-1.6	-0.9	1.2
Lung FEV1/FVC ratio	0.7	3.5	6.8	1.2	2.6	2.2	2.1	1.8	-0.5
Hand grip strength (left)	0.7	1.7	4.7	0.0	-1.5	-2.2	-1.7	-0.8	-0.3
Allergy	0.7	1.5	3.6	0.5	-1.1	-0.7	-1.2	-1.4	-1.9
Impedance of arm (right)	0.7	3.0	6.5	1.7	1.8	1.7	2.5	0.8	-1.4
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	3.0	-1.2	-0.6	-1.7	-0.8	-1.0	0.5
Pulse wave reflection index	0.7	0.9	1.7	0.2	1.1	1.3	1.0	1.1	0.6
Headache pain in last month	0.7	1.1	3.7	0.6	1.9	0.6	0.3	1.3	-0.7
Medication: Ventolin 100micrograms inhaler	0.7	0.9	4.6	-0.5	0.2	0.3	-0.6	0.2	2.2
Leg fat percentage (right)	0.7	2.4	7.5	0.6	2.0	2.7	1.0	1.2	-0.3
Emphysema/chronic bronchitis	0.7	0.8	1.9	1.2	0.4	0.1	1.4	1.0	0.5
Heart disease (mother)	0.7	0.8	1.9	-1.2	0.5	0.5	0.8	1.4	0.7
Family relationship satisfaction	0.7	0.9	2.0	0.1	1.0	1.2	1.4	0.8	-0.5
Supplements: Vitamin C	0.7	0.9	3.3	-0.3	-0.2	-1.8	-0.7	-0.8	-0.8
Illnesses of father: Heart disease	0.7	1.0	2.4	-1.6	-0.7	-0.0	-1.3	-1.1	0.1
Average weekly red wine intake	0.7	1.0	4.1	0.6	0.8	0.6	-0.5	-0.6	-2.0
Arm fat mass (left)	0.7	3.0	8.0	1.0	2.8	2.3	1.1	1.3	-0.9
Medication: Lisinopril	0.7	0.9	2.1	-0.6	1.5	0.6	-0.2	-0.8	-1.4
Leg fat percentage (left)	0.7	2.5	7.5	0.6	2.2	2.7	1.1	0.8	-0.6
Fractured/broken bones in last 5 years	0.7	1.0	2.4	0.4	0.7	1.1	1.6	-0.3	-1.2
Basal cell carcinoma (self-reported)	0.7	0.9	1.6	0.7	1.2	0.5	1.3	0.6	-1.1
Alzheimer’s Disease (in mother)	0.6	0.7	1.7	-0.8	-0.8	-0.1	-1.3	-0.9	-0.5
LDL Cholesterol	0.6	0.9	2.1	0.8	1.1	1.4	0.8	0.7	-0.1
Cardiovascular Disease	0.6	1.8	4.6	-0.5	1.5	2.1	1.4	0.5	-1.3
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.8	-1.1	0.7	-0.7	-0.3	-1.2	-1.7
Hearing difficulty/problems: Yes	0.6	1.0	2.3	0.8	1.2	-0.2	-1.2	-0.3	-1.5
Medication: Metformin	0.6	0.8	2.9	-1.2	-0.2	0.3	-0.5	-1.7	-0.4
Average weekly fortified wine intake	0.6	0.7	1.1	1.1	0.7	1.0	0.9	0.2	-1.0
Arm fat percentage (right)	0.6	2.3	5.6	0.4	2.4	2.3	1.3	1.0	-0.6
Happiness	0.6	0.8	2.2	-0.7	0.0	0.8	0.0	1.5	1.1
Arm fat mass (right)	0.6	2.3	5.6	0.8	2.4	2.2	0.8	1.2	-0.8
Standing height	0.6	5.9	12.0	3.4	3.5	1.9	1.6	1.6	-1.7
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	3.0	-1.7	-0.2	-1.0	-1.0	-1.1	-1.0
Comparative body size at age 10	0.6	1.7	3.2	0.3	-1.8	-1.1	-1.5	0.6	1.7
Medication for pain relief, constipation, heartburn	0.6	1.0	1.5	1.1	0.8	1.2	1.2	0.4	0.9
Migraine (self-reported)	0.6	0.7	1.8	0.4	1.4	0.1	0.7	1.2	-0.4
Wears glasses or contact lenses	0.6	0.7	1.1	-0.8	0.5	1.1	-0.7	-0.6	-1.0
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.2	0.8	1.1	0.9	0.9	0.7	-0.2
Medication: Bendroflumethiazide	0.6	0.9	2.1	0.5	1.1	1.4	0.5	0.2	-1.4
Impedance of whole body	0.6	3.0	6.0	1.9	1.4	1.9	2.5	0.5	-1.5
Schizophrenia (2018)	0.5	1.0	3.5	-1.1	-1.0	-1.9	-0.6	0.1	0.4
Mean Putamen Volume	0.5	0.5	1.2	0.9	0.1	-0.2	1.1	0.7	0.9
Waist Hip Ratio (WHR)	0.5	2.1	5.4	-0.7	-2.0	-1.4	-0.8	-2.3	-0.3
Systolic Blood Pressure	0.5	2.4	4.7	-1.5	-0.2	2.0	2.2	1.0	1.5
Systolic blood pressure, automated reading	0.5	1.5	2.9	-0.6	0.3	1.7	1.1	1.4	1.6
Qualifications: CSEs or equivalent	0.5	0.6	1.9	1.4	0.2	0.5	0.6	1.2	-0.1
Multivitamins +/- minerals	0.5	0.6	1.6	1.1	0.6	0.3	1.3	0.0	-0.4
Impedance of leg (left)	0.5	2.3	4.5	1.7	0.9	1.9	2.1	0.2	-1.3
Mouth/teeth dental problems	0.5	0.8	2.1	1.4	1.1	0.6	0.7	0.5	-0.8
Medication: Ramipril	0.5	0.6	2.1	-0.3	-0.4	1.4	0.4	1.0	0.3
Number of live births	0.5	0.7	1.3	-1.0	-0.2	1.1	0.6	0.4	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	2.3	-1.5	0.2	-0.4	-0.4	-0.7	-0.3
Mouth/teeth dental problems: Dentures	0.5	0.8	1.5	-1.2	-1.2	-0.8	-0.0	-1.2	0.1
Asthma	0.5	1.0	2.5	-1.0	1.2	0.3	-0.6	0.8	1.6
Depression (self-reported)	0.5	0.6	1.6	-1.3	0.8	0.4	-0.7	0.5	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.8	-0.4	-0.2	-1.2	0.3	1.4	0.6
Medication: Omeprazole	0.5	0.6	1.2	-0.6	-0.7	-0.8	-1.1	-0.9	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.0	-0.4	-0.9	-0.7	-1.4	-0.1	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.3	-1.0	-0.6	-0.7	-0.6	0.2	1.1
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.3	-0.5	-1.1	-0.8	-0.7	-0.4	0.6
Eye problems/disorders: Cataract	0.5	0.6	1.6	-1.1	-0.5	-0.0	-0.4	0.3	1.3
Breast cancer (self-reported)	0.5	0.6	2.1	0.4	0.6	1.4	0.6	0.2	0.7
Asthma (self-reported)	0.5	0.9	2.0	-0.9	1.2	0.2	-0.7	0.7	1.4
Unable to work because of sickness or disability	0.5	0.6	2.7	-1.7	-0.4	-0.1	0.1	-0.5	0.8
Alcohol drinker status: Previous	0.5	0.6	1.1	-0.9	0.4	0.6	-0.4	0.9	1.0
Ulcerative Colitis (UC)	0.4	0.8	2.5	0.2	-1.0	0.3	-0.2	0.9	1.6
Breast Cancer	0.4	0.9	3.8	-0.6	-1.9	-0.8	0.3	0.4	-0.3
Prostate Cancer	0.4	0.5	1.4	0.1	0.7	0.3	1.2	1.0	-0.2
Lupus	0.4	0.6	1.8	-0.7	-1.3	-0.7	0.2	-0.5	0.9
Blood Platelet Count	0.4	4.6	9.0	-3.0	-2.1	-2.0	-1.1	-3.0	-0.4
Heel T-Score	0.4	3.6	5.6	-2.0	-2.0	-2.0	-1.9	-0.1	2.4
Allergy or Eczema	0.4	1.0	3.4	-1.1	-0.0	0.3	0.7	0.9	1.9
Hypothyroidism (self reported)	0.4	1.0	1.8	-1.3	-0.1	-1.2	-0.6	-1.2	-1.0
Average weekly spirits intake	0.4	0.4	1.0	-1.0	-0.7	0.1	0.4	0.1	1.0
Medication: Co-codamol	0.4	0.5	1.6	0.5	0.8	1.3	0.3	0.3	-0.7
Impedance of leg (right)	0.4	2.1	4.2	1.6	0.7	2.0	2.0	0.7	-0.9
Serious illness, injury or assault to yourself	0.4	0.5	1.4	-0.4	0.7	-0.5	0.7	-0.2	-1.2
High blood pressure	0.4	1.0	2.5	-1.6	0.9	1.2	0.1	-0.2	-1.1
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.2	-1.0	0.1	0.4	0.9	0.8	1.5
Medication: Levothyroxine sodium	0.4	0.6	1.6	-0.9	-0.0	-0.7	-0.2	-0.9	-1.3
Waist circumference	0.4	1.5	4.1	0.5	1.9	2.0	0.3	0.7	-0.6
Hair/balding pattern: Pattern 2	0.4	0.5	2.3	-0.6	-0.1	0.1	-1.5	0.5	0.5
Had menopause	0.4	0.6	1.2	-0.2	-0.4	1.0	0.6	0.8	1.1
Forced vital capacity (FVC)	0.4	1.5	4.5	2.1	1.1	0.8	0.6	1.2	0.8
Financial difficulties in last 2 years	0.4	0.5	1.0	-1.0	-0.5	-1.0	-0.7	-0.1	0.3
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.8	0.1	0.2	-0.1	1.3	0.8	0.5
Falls in the last year	0.4	0.5	2.8	-0.3	0.3	0.1	1.7	0.3	-0.1
Lung cancer (father)	0.4	0.4	2.0	-0.5	-0.0	0.3	0.6	0.0	1.4
Pulse wave Arterial Stiffness index	0.4	0.4	1.2	0.1	0.8	0.7	1.1	0.4	0.1
Birth weight of first child	0.4	0.8	2.3	1.1	0.5	0.4	1.5	0.2	-0.9
Forced vital capacity (FVC), Best measure	0.4	1.4	5.1	2.2	0.9	0.7	0.5	1.3	0.5
Medication: Seretide 50 evohaler	0.4	0.5	1.0	-1.0	-0.3	-0.6	-0.9	-0.9	0.2
Overall health rating	0.4	0.8	2.3	-1.1	0.4	1.5	0.5	0.4	0.9
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.0	0.2	0.0	0.7	-1.4	0.1	0.5
Handedness (chirality/laterality): Left-handed	0.4	0.4	1.0	-0.7	-0.3	0.9	0.3	-0.3	1.0
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	2.1	0.2	0.1	-0.1	-1.4	-1.2	-0.5
Back pain experienced in last month	0.4	0.6	0.9	-0.9	-0.9	-0.9	-0.8	-0.6	0.2
Medication: Aspirin	0.4	0.5	1.2	-0.2	-0.6	-0.7	-0.8	-0.5	-1.1
Average weekly champagne plus white wine intake	0.4	0.6	1.1	-1.0	-0.9	-0.4	-0.2	1.0	0.8
Hearing aid user	0.4	0.5	1.1	-0.4	-0.9	-0.1	-1.0	-0.5	0.7
Commuting to job workplace: Public transport	0.4	0.5	2.4	0.1	0.3	0.4	-0.5	-0.5	-1.6
Average weekly beer plus cider intake	0.4	0.6	2.2	0.4	-0.0	-0.4	-1.5	-1.1	0.0
Ever depressed for a whole week	0.4	0.4	1.1	-0.3	-0.0	-0.5	0.6	-0.9	-1.1
Heart disease (siblings)	0.4	0.5	1.3	0.2	1.1	0.1	0.2	-0.4	-1.1
Irritable Bowel Disease (IBD)	0.3	0.6	1.5	0.5	-0.2	1.1	0.4	0.8	1.2
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	-0.5	0.1	-0.1	-0.1	-1.0	-1.0
HbA1C	0.3	0.3	1.4	-0.4	-0.2	-0.5	-0.4	-1.2	-0.1
Ulcerative Colitis	0.3	0.4	1.3	-0.3	-0.7	0.5	-0.4	-0.3	1.2
Blood Eosinophil Count	0.3	2.5	4.4	-0.9	-1.1	-2.1	-1.6	-1.6	-1.7
Height	0.3	6.4	14.7	3.8	3.0	2.0	0.8	2.4	-2.1
Respiratory disease	0.3	0.7	2.5	-1.2	-0.2	-0.3	-0.1	0.1	1.6
Number of treatments/medications taken	0.3	0.6	2.4	-1.6	0.1	0.1	-0.6	-0.7	-0.6
Vitamin and mineral supplements	0.3	0.4	1.0	-0.3	0.1	0.8	-0.6	1.0	0.4
Leg fat-free mass (left)	0.3	1.4	5.3	0.8	2.3	1.0	0.1	1.2	-0.5
Body mass index (BMI)	0.3	1.3	3.2	0.1	1.8	1.8	0.3	1.1	-0.1
Leg predicted mass (left)	0.3	1.4	5.3	0.8	2.3	1.0	0.0	1.2	-0.6
Time employed in main current job	0.3	0.4	1.0	0.3	-0.2	-1.0	-0.9	-0.6	-0.3
Alcohol intake versus 10 years previously	0.3	0.4	1.6	0.3	-0.6	-1.3	0.5	-0.5	-0.4
Father’s age at death	0.3	0.4	2.1	0.1	-0.0	-0.1	0.5	0.4	-1.4
Illnesses of mother	0.3	0.4	1.1	0.3	-0.9	-0.4	-0.0	-1.0	-0.2
Length of working week for main job	0.3	0.3	0.9	-0.9	-0.2	0.4	0.1	-0.4	0.9
Exposure to tobacco smoke at home	0.3	0.3	1.3	1.1	-0.3	0.4	-0.1	0.2	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	2.6	-0.3	0.2	-0.1	0.2	1.6	0.7
Loud music exposure frequency	0.3	0.4	1.0	0.4	-0.3	0.2	-0.0	1.0	1.0
Medication: Paracetamol	0.3	0.4	0.8	-0.9	0.7	0.9	0.2	0.6	0.1
High blood pressure (siblings)	0.3	0.5	1.0	0.6	1.0	0.7	0.6	0.4	-0.7
Pulse wave peak to peak time	0.3	0.3	0.9	0.1	-0.5	-0.6	-1.0	-0.4	-0.4
Medication: Allopurinol	0.3	0.4	0.6	0.5	0.8	0.7	0.8	-0.3	-0.4
Alcohol intake frequency.	0.3	0.6	1.7	-1.3	0.2	-0.4	0.0	1.2	0.5
Comparative height size at age 10	0.3	1.8	4.4	1.2	1.5	1.0	1.0	-0.7	-2.1
Medication: Aspirin	0.3	0.3	1.9	0.3	-0.0	-0.2	-0.0	-0.0	-1.4
Hypertension (Self-reported)	0.3	1.0	2.2	-1.2	0.9	1.5	0.3	0.2	-1.1
Medication for cholesterol	0.3	0.5	1.8	-0.2	-0.3	-1.4	-0.3	-0.6	0.6
Basal metabolic rate	0.3	1.4	5.0	1.0	2.2	1.0	-0.1	1.0	-0.7
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.4	1.3	-0.3	-0.7	0.4	0.6	1.6
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.8	0.0	-0.9	-0.8	-0.5	-0.4	0.6
Alzheimer’s Disease (including proxy)	0.2	0.3	1.2	-0.1	-0.7	0.6	-0.0	-0.2	1.1
Crohns Disease (2017)	0.2	0.5	1.4	-0.4	-0.3	1.2	0.5	-0.0	0.9
Fasting Glucose	0.2	0.2	0.8	-0.5	0.9	-0.2	0.1	-0.2	-0.1
Triglycerides	0.2	0.4	1.0	-0.6	0.0	0.1	0.9	0.1	1.0
Lung FVC	0.2	1.1	3.6	1.9	0.2	-0.3	0.7	0.9	1.3
Relative age voice broke	0.2	0.3	0.6	0.7	0.2	0.8	0.8	0.5	0.1
Age when periods started (menarche)	0.2	0.4	1.0	0.8	-0.2	-0.1	-1.0	0.9	0.4
Medication: Atenolol	0.2	0.2	0.5	-0.1	0.1	-0.3	0.5	0.7	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	1.3	-1.1	-1.0	-0.7	-0.5	-0.4	0.4
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.7	-0.9	-0.2	0.1	-0.8	0.1	0.6
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.4	-0.2	-0.5	-0.3	0.6	0.7	0.5
Age at first live birth	0.2	0.3	0.9	0.5	-0.4	-1.0	0.0	0.3	0.5
Health satisfaction	0.2	0.2	0.5	0.1	-0.0	0.7	0.4	0.7	0.4
Arm predicted mass (right)	0.2	0.8	2.3	1.0	1.5	0.5	-0.7	0.5	-0.6
Chest pain or discomfort	0.2	0.2	0.9	-0.9	-0.3	-0.6	0.2	-0.1	-0.3
Age at last live birth	0.2	0.4	1.1	-0.7	-0.5	0.2	0.4	0.4	1.0
Leg pain on walking	0.2	0.3	1.0	-0.6	-0.3	-0.6	-0.2	0.1	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	1.0	0.1	1.0	-0.1	-0.1	-0.0	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.7	-0.8	0.6	-0.0	-0.6	-0.1	0.6
Leg fat-free mass (right)	0.2	1.1	4.6	0.6	2.1	0.6	-0.2	0.7	-0.8
Friendships satisfaction	0.2	0.2	0.7	-0.2	0.6	0.3	0.9	0.0	0.0
Commuting to job workplace: Walk	0.2	0.2	0.6	0.4	-0.1	-0.4	0.2	0.3	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.5	1.2	0.0	0.6	0.7	0.3	-0.1
Leg predicted mass (right)	0.2	1.2	4.9	0.7	2.2	0.6	-0.1	0.7	-0.8
Ever taken oral contraceptive pill	0.2	0.2	0.5	0.2	-0.7	-0.6	0.0	-0.2	0.5
Medication: Paracetamol	0.2	0.2	1.2	-1.1	0.1	0.4	0.0	0.3	-0.1
Myopia	0.2	0.3	0.7	0.2	-0.4	-0.9	0.5	0.1	0.7
Blood Red Count	0.1	0.5	2.2	-1.5	-0.5	-0.2	0.7	0.0	0.4
BMI	0.1	0.7	1.3	-1.1	1.1	1.1	0.0	0.4	-0.6
Chronotype (morning person)	0.1	0.3	1.0	-0.5	-0.1	-1.0	-0.0	0.2	-0.5
Angina	0.1	0.2	0.7	0.8	-0.3	-0.1	0.1	0.0	-0.4
Hand grip strength (right)	0.1	0.3	0.7	-0.1	-0.5	-0.8	-0.4	0.4	0.6
Alcohol usually taken with meals	0.1	0.2	0.4	-0.2	0.5	0.6	0.2	0.7	-0.5
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.6	-0.4	0.1	-0.8	-0.2	-0.3	-0.4
Trunk fat-free mass	0.1	0.6	2.1	0.8	1.4	0.2	-0.6	0.6	-0.4
Pulse rate	0.1	0.2	0.5	-0.4	0.7	0.3	0.5	0.4	-0.2
Trunk predicted mass	0.1	0.6	2.1	0.8	1.4	0.3	-0.6	0.6	-0.3
Medication: Amlodipine	0.1	0.1	0.3	-0.0	-0.3	-0.0	-0.5	0.4	-0.6
Arm fat-free mass (right)	0.1	0.7	2.5	0.8	1.6	0.5	-0.6	0.4	-0.6
Angina (self-reported)	0.1	0.2	0.7	0.8	-0.3	-0.1	0.2	0.1	-0.4
Pulse rate, automated reading	0.1	0.4	1.6	-1.3	-0.3	-0.1	0.3	-0.5	0.5
Whole body fat-free mass	0.1	0.8	3.1	0.8	1.8	0.4	-0.5	0.6	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.2	0.4	0.3	0.6	0.3	0.1	0.1	0.6
Whole body water mass	0.1	0.8	3.3	0.7	1.8	0.4	-0.5	0.6	-0.6
Arm fat-free mass (left)	0.1	0.5	1.6	0.6	1.3	0.3	-0.8	0.2	-0.6
Arm predicted mass (left)	0.1	0.8	2.2	1.1	1.5	0.6	-0.3	0.7	-0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

Hub : Genes

MAP1LC3B

Models

Trait associations