Hub : Traits :

Heel bone mineral density (BMD) T-score, automated (right)

797 significantly associated models · 263 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 752566 1567206 1 1 4.4e-08 4.9e-07 1.0e+00 100 KLHL17
2 1 7686056 9571422 3 1 2.0e-14 6.8e-12 3.2e-01 98 RERE
3 1 15123100 16844848 5 2 6.0e-11 4.0e-10 6.9e-01 100 C1orf134 CASP9
4 1 18972776 20503710 1 1 1.6e-07 2.3e-08 3.0e-02 85 CAPZB
5 1 37764586 39167106 1 1 1.9e-08 3.7e-07 7.1e-01 100 FHL3
6 1 112312154 114196883 4 1 6.2e-16 7.0e-15 1.0e+00 100 WNT2B
7 1 118878656 120380990 1 1 1.0e-07 1.4e-09 7.6e-06 45 WARS2
8 1 219166366 220808921 1 1 4.6e-09 9.7e-10 6.8e-02 91 SLC30A10
9 1 239954252 241470634 1 1 9.9e-41 1.2e-53 1.3e-16 71 GREM2
10 2 39636469 41534961 1 1 3.5e-09 1.7e-12 7.0e-08 42 SLC8A1
11 2 41579722 42984340 1 1 2.9e-12 1.9e-25 3.4e-15 43 PKDCC
12 2 53507604 55895321 8 7 1.9e-37 5.6e-66 NaN NaN AC093110.3 ACYP2 EML6 HMGB1P31 SPTBN1
13 2 64168232 65573478 1 1 1.5e-07 4.7e-08 3.5e-02 85 SERTAD2
14 2 118148428 119553132 1 1 3.0e-08 5.0e-38 9.1e-34 12 INSIG2
15 2 202200575 203592180 1 1 5.9e-10 6.5e-30 6.4e-27 11 FZD7
16 3 48012797 50800146 22 1 2.9e-12 7.5e-12 5.1e-02 92 AMT
17 3 155695485 157456920 4 9 5.1e-14 1.4e-13 NaN NaN LEKR1 LINC00886 METTL15P1 TIPARP
18 4 69713 2058475 13 10 2.8e-36 6.0e-33 NaN NaN CRIPAK FGFRL1 IDUA RP11-20I20.4
19 4 85698680 89692911 6 5 1.5e-12 5.7e-12 1.0e+00 100 HSD17B13 IBSP PKD2 RP13-514E23.2 SPP1
20 4 144882744 147278056 2 2 1.4e-12 2.5e-13 4.1e-03 85 HHIP-AS1 MMAA
21 5 41726855 43401980 1 1 4.0e-08 2.0e-08 9.4e-02 91 GHR
22 5 53906103 55410585 1 1 2.5e-07 1.2e-06 9.4e-01 100 SKIV2L2
23 6 44079216 46043561 1 2 1.5e-17 1.7e-24 1.6e-11 56 SUPT3H
24 6 73710903 75236060 1 1 3.1e-10 4.8e-13 3.6e-04 76 CD109
25 6 126752798 128536730 4 2 4.8e-77 4.5e-88 1.4e-10 90 ECHDC1 RSPO3
26 6 132368241 134546685 5 4 1.1e-11 8.8e-42 2.7e-18 58 EYA4 LINC00326 RPS12 VNN2
27 6 151030107 153120904 5 5 1.2e-20 1.8e-69 6.9e-57 19 C6orf97 CCDC170 ESR1 RMND1
28 7 14953576 16424863 1 1 3.4e-07 3.9e-10 1.0e-05 50 MEOX2
29 7 26871554 28568019 3 1 2.3e-10 1.9e-15 1.6e-11 28 AC004549.6
30 7 37250727 38764855 2 2 1.3e-17 5.8e-41 4.2e-29 30 EPDR1
31 7 91380845 93160671 2 1 6.3e-10 2.6e-09 2.8e-01 97 CDK6
32 7 119892061 121729795 5 7 1.8e-235 0.0e+00 NaN NaN C7orf58 CPED1 FAM3C
33 7 148285882 149691341 1 1 1.6e-07 1.0e-07 1.0e+00 100 RP4-800G7.2
34 7 150034951 151443931 1 1 9.1e-08 1.7e-07 2.5e-02 82 ABCB8
35 8 8092025 13120332 38 8 3.3e-22 1.9e-26 NaN NaN AF131215.9 ERI1 FAM66A FDFT1 PPP1R3B RP11-981G7.6 SGK223
36 8 70890495 72399360 1 1 1.0e-07 8.3e-10 1.9e-08 16 XKR9
37 9 96102832 97759920 2 2 1.0e-08 3.4e-09 4.9e-03 77 PTPDC1 ZNF169
38 10 122801759 124407934 2 2 3.2e-10 8.0e-10 7.4e-03 81 RP11-500G22.2
39 11 16072004 17469466 1 1 2.7e-07 4.5e-10 1.0e-06 39 C11orf58
40 11 26693196 28220506 2 2 1.7e-16 3.2e-27 1.5e-08 73 LGR4 LIN7C
41 11 34460769 35949179 1 1 1.6e-11 4.9e-12 1.0e+00 100 CD44
42 11 45945837 48285906 14 1 1.4e-16 6.9e-17 1.6e-02 92 ZNF408
43 11 59239839 60768044 2 1 5.8e-09 1.3e-10 2.5e-03 78 MS4A6A
44 11 60869481 62346131 3 1 2.4e-10 3.4e-08 4.4e-01 98 FADS2
45 11 64669105 66714782 4 2 3.3e-10 5.2e-08 5.5e-01 99 RP11-867G23.1 SIPA1
46 11 67339278 69623641 9 4 4.2e-16 9.2e-21 1.3e-02 93 C11orf24 GAL IGHMBP2 TPCN2
47 11 74119638 75612878 1 1 1.2e-08 2.0e-06 1.6e-02 74 SLCO2B1
48 11 111325300 112921923 3 2 1.2e-30 3.2e-48 5.0e-15 71 IL18 RP11-356J5.12
49 11 114340771 116072203 1 1 9.4e-12 9.4e-16 1.9e-05 72 CADM1
50 11 118466249 119878269 1 1 3.1e-09 2.7e-09 1.1e-07 20 CBL
51 12 191619 1368535 1 1 2.0e-07 1.1e-06 7.1e-01 99 B4GALNT3
52 12 25417418 26928426 1 1 5.9e-09 2.2e-07 6.3e-02 87 RASSF8
53 12 49827409 51256065 1 1 2.2e-07 3.9e-05 2.8e-01 93 CERS5
54 12 89406493 90799212 1 1 5.7e-12 5.8e-31 6.8e-23 28 LOC338758
55 12 123558705 125155900 3 1 3.7e-09 1.0e-06 1.7e-01 92 DNAH10
56 13 49557805 50962458 1 1 5.3e-09 1.4e-06 4.3e-03 65 EBPL
57 13 98746497 100437143 2 3 1.4e-17 3.3e-19 4.9e-02 95 DOCK9 DOCK9-AS2
58 14 34754717 36242995 2 1 1.4e-10 1.4e-10 1.0e+00 100 SRP54
59 14 53731553 55118795 1 1 2.4e-34 2.3e-34 9.8e-07 84 BMP4
60 14 60168943 61664530 1 1 3.7e-08 6.4e-08 3.3e-01 97 C14orf39
61 14 103161201 104892153 8 1 8.0e-17 4.3e-17 1.0e+00 100 MARK3
62 15 50509591 51995763 1 1 5.1e-08 2.2e-14 1.2e-09 37 AP4E1
63 15 90208219 91886448 3 1 1.5e-08 5.8e-09 1.0e+00 100 ZNF774
64 16 86671 1100776 1 1 8.5e-08 7.8e-09 2.9e-03 74 TMEM8A
65 16 66510153 68536105 6 1 1.5e-10 6.3e-14 9.4e-05 73 CTCF
66 17 41393295 43164246 8 1 6.9e-14 3.3e-17 1.5e-12 30 HDAC5
67 18 12966058 14385836 1 1 6.9e-08 6.3e-24 1.0e-17 28 FAM210A
68 19 32372820 34457352 11 6 1.9e-36 4.8e-46 4.0e-04 94 CTD-2540B15.12 GPATCH1 RHPN2
69 20 32819871 34556216 5 1 7.0e-10 1.1e-09 1.0e+00 100 MYH7B
70 22 19003938 20330744 1 1 8.0e-09 2.2e-40 2.9e-33 18 SEPT5
71 22 27675538 30261219 2 2 6.8e-23 5.8e-23 1.0e+00 100 KREMEN1 TTC28
72 22 38388203 39770597 1 1 2.1e-07 9.7e-07 6.2e-01 99 TOMM22
73 22 40789606 42301748 2 1 9.7e-08 4.1e-08 1.0e+00 100 L3MBTL2
74 22 49550794 51017353 3 1 7.5e-09 4.1e-09 9.3e-02 92 ALG12

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (including proxy) 1.13 1 1 3.0 0.00 1.0e+00 MS4A6A
Crohns Disease (2017) 1.27 4 2 6.1 0.31 6.9e-01 ALG12 AMT MARK3 RSPO3
Irritable Bowel Disease (IBD) 1.04 2 1 3.0 0.00 1.0e+00 AMT MARK3
Reaction Time 0.91 2 0 0.0 0.00 1.0e+00 DNAH10 ZNF408
Verbal and Numeric Reasoning (VNR) 0.98 2 0 0.0 0.00 1.0e+00 AMT XKR9
Breast Cancer 1.41 4 2 6.1 0.67 1.0e-01 LINC00886 METTL15P1 RMND1 RP11-500G22.2
Bipolar Disorder 1.28 1 0 0.0 0.00 1.0e+00 MYH7B
Coronary Artery Disease (CAD) 1.17 1 0 0.0 0.00 1.0e+00 DNAH10
Crohns Disease (2012) 1.19 2 1 3.0 0.00 1.0e+00 AMT RSPO3
HDL Cholesterol 1.47 5 2 6.1 -0.10 8.8e-01 CTD-2540B15.12 DNAH10 FADS2 RSPO3 ZNF408
LDL Cholesterol 1.10 1 1 3.0 0.00 1.0e+00 FADS2
Lupus 1.29 3 1 3.0 0.00 1.0e+00 AF131215.9 CD44 ERI1
Neuroticism 1.88 3 3 9.1 0.00 1.0e+00 AF131215.9 ERI1 FAM66A
Rheumatoid Arthritis 1.49 2 0 0.0 0.00 1.0e+00 CDK6 FADS2
Schizophrenia 1.21 1 1 3.0 0.00 1.0e+00 RERE
Triglycerides 1.75 6 1 3.0 0.08 8.8e-01 DNAH10 FADS2 FAM66A HSD17B13 RSPO3 ZNF408
Blood Eosinophil Count 0.82 15 8 24.2 -0.14 6.2e-01 AC093110.3 AMT C1orf134 CDK6 CTCF EBPL FADS2 L3MBTL2 LGR4 MARK3 RERE RP11-867G23.1 RP4-800G7.2 SIPA1 ZNF169
Blood Platelet Count 1.22 19 13 39.4 -0.05 8.5e-01 ALG12 C1orf134 CAPZB CBL CDK6 CERS5 CTD-2540B15.12 DOCK9 FADS2 HDAC5 HSD17B13 MARK3 RP13-514E23.2 RSPO3 SEPT5 SERTAD2 TIPARP TOMM22 WNT2B
Blood Red Count 0.91 19 10 30.3 0.11 6.2e-01 ABCB8 AC093110.3 AMT C11orf58 C14orf39 CCDC170 CERS5 CTD-2540B15.12 DNAH10 FADS2 FZD7 HDAC5 MARK3 RSPO3 SERTAD2 SLCO2B1 SPTBN1 TIPARP TMEM8A
Blood White Count 0.83 14 6 18.2 0.20 5.0e-01 CDK6 CERS5 DNAH10 DOCK9-AS2 FADS2 FHL3 MS4A6A RERE RP13-514E23.2 SPTBN1 SUPT3H TIPARP TPCN2 ZNF169
Heel T-Score 39.48 109 107 324.2 -0.99 1.3e-110 ABCB8 AC004549.6 AC093110.3 ACYP2 ALG12 AMT AP4E1 B4GALNT3 BMP4 C11orf24 C11orf58 C14orf39 C1orf134 C6orf97 C7orf58 CADM1 CAPZB CASP9 CBL CCDC170 CD109 CD44 CDK6 CERS5 CPED1 CRIPAK CTCF CTD-2540B15.12 DNAH10 DOCK9 DOCK9-AS2 EBPL ECHDC1 EML6 EPDR1 ESR1 EYA4 FADS2 FAM210A FAM3C FGFRL1 FHL3 FZD7 GAL GHR GPATCH1 GREM2 HDAC5 HHIP-AS1 HMGB1P31 HSD17B13 IBSP IDUA IGHMBP2 IL18 INSIG2 KLHL17 KREMEN1 L3MBTL2 LEKR1 LGR4 LIN7C LINC00326 LINC00886 LOC338758 MARK3 MEOX2 METTL15P1 MMAA MS4A6A MYH7B PKD2 PKDCC PTPDC1 RASSF8 RERE RHPN2 RMND1 RP11-20I20.4 RP11-356J5.12 RP11-500G22.2 RP11-867G23.1 RP13-514E23.2 RP4-800G7.2 RPS12 RSPO3 SEPT5 SERTAD2 SIPA1 SKIV2L2 SLC30A10 SLC8A1 SLCO2B1 SPP1 SPTBN1 SRP54 SUPT3H TIPARP TMEM8A TOMM22 TPCN2 TTC28 VNN2 WARS2 WNT2B XKR9 ZNF169 ZNF408 ZNF774
BMI 0.81 13 6 18.2 -0.36 2.3e-01 AMT C11orf24 CADM1 CBL CERS5 DNAH10 HMGB1P31 IGHMBP2 L3MBTL2 LOC338758 MARK3 MYH7B WARS2
Height 2.17 54 38 115.2 -0.04 7.5e-01 ALG12 AP4E1 B4GALNT3 C11orf24 C14orf39 C1orf134 C7orf58 CADM1 CAPZB CDK6 CPED1 CRIPAK CTCF CTD-2540B15.12 DNAH10 DOCK9 EBPL EML6 EPDR1 FADS2 FGFRL1 FHL3 GAL GHR GPATCH1 HHIP-AS1 HMGB1P31 HSD17B13 IBSP KREMEN1 LINC00326 LINC00886 MARK3 MYH7B RHPN2 RP11-20I20.4 RP11-500G22.2 RP13-514E23.2 RP4-800G7.2 RPS12 RSPO3 SLC8A1 SLCO2B1 SPP1 SPTBN1 SUPT3H TIPARP TOMM22 TPCN2 WARS2 WNT2B ZNF169 ZNF408 ZNF774
Waist Hip Ratio (WHR) 3.48 21 15 45.5 -0.13 5.5e-01 ABCB8 AMT C7orf58 CPED1 CRIPAK CTD-2540B15.12 DNAH10 ECHDC1 FAM3C FGFRL1 HDAC5 HHIP-AS1 LINC00886 MYH7B RSPO3 SIPA1 SLC30A10 TIPARP TPCN2 WARS2 XKR9
Systolic Blood Pressure 1.42 14 9 27.3 -0.30 2.6e-01 ALG12 AP4E1 BMP4 C1orf134 CASP9 CDK6 CRIPAK ESR1 FHL3 RERE RP13-514E23.2 SIPA1 WNT2B ZNF408
Smoking Status 0.80 2 1 3.0 0.00 1.0e+00 MARK3 RERE
Allergy or Eczema 1.06 4 2 6.1 -0.29 7.1e-01 RERE RP11-867G23.1 RP4-800G7.2 ZNF774
Cardiovascular Disease 1.01 5 1 3.0 -0.43 4.7e-01 CDK6 KREMEN1 MARK3 RP13-514E23.2 SIPA1
Hypothyroidism (self reported) 1.12 3 1 3.0 0.00 1.0e+00 CADM1 FADS2 FHL3
Respiratory disease 1.21 3 2 6.1 0.00 1.0e+00 FADS2 RERE ZNF169
Type 2 Diabetes (T2D) 1.14 1 0 0.0 0.00 1.0e+00 MARK3
Lung FEV1/FVC ratio 1.86 11 8 24.2 0.30 3.0e-01 BMP4 C1orf134 DOCK9-AS2 FAM3C HHIP-AS1 L3MBTL2 LINC00886 METTL15P1 PPP1R3B RERE SERTAD2
Lung FVC 1.00 9 4 12.1 -0.55 1.2e-01 BMP4 CD109 CERS5 DNAH10 EBPL IGHMBP2 MYH7B RSPO3 WNT2B
Neuroticism 0.99 4 1 3.0 -0.43 5.7e-01 LEKR1 RERE TIPARP ZNF408
Chronotype (morning person) 1.31 2 1 3.0 0.00 1.0e+00 CRIPAK RP11-500G22.2
Hair Pigment 0.48 16 10 30.3 -0.36 1.7e-01 C11orf24 C11orf58 C14orf39 CD44 FADS2 GAL IGHMBP2 LINC00886 MARK3 MYH7B PPP1R3B SIPA1 SUPT3H TPCN2 ZNF408 ZNF774
Tanning 0.49 5 5 15.2 0.36 3.4e-01 IGHMBP2 LEKR1 LINC00886 METTL15P1 MYH7B
Hand grip strength (left) 1.43 3 1 3.0 -0.93 6.4e-03 C7orf58 CRIPAK DNAH10
Number of treatments/medications taken 0.88 1 0 0.0 0.00 1.0e+00 FADS2
Sensitivity / hurt feelings 1.15 3 2 6.1 0.00 1.0e+00 AF131215.9 ERI1 FAM66A
Frequency of depressed mood in last 2 weeks 1.33 2 0 0.0 0.00 1.0e+00 ERI1 ZNF408
Hearing difficulty/problems: Yes 1.34 1 0 0.0 0.00 1.0e+00 LINC00326
Relative age of first facial hair 0.86 1 0 0.0 0.00 1.0e+00 SIPA1
Ever had hysterectomy (womb removed) 1.57 1 0 0.0 0.00 1.0e+00 CD109
Systolic blood pressure, automated reading 1.91 14 7 21.2 0.52 5.8e-02 AF131215.9 AP4E1 CDK6 ERI1 ESR1 FAM66A FDFT1 FHL3 MYH7B PPP1R3B RERE RP11-981G7.6 RP13-514E23.2 WNT2B
Angina 1.04 1 0 0.0 0.00 1.0e+00 CADM1
Impedance of leg (right) 1.71 18 11 33.3 -0.52 2.9e-02 AF131215.9 C11orf24 C1orf134 CADM1 CDK6 CRIPAK ERI1 FAM66A FDFT1 GAL GHR IBSP IGHMBP2 L3MBTL2 MARK3 PPP1R3B WARS2 WNT2B
Leg fat-free mass (left) 2.01 28 16 48.5 0.33 6.2e-02 ABCB8 AF131215.9 AP4E1 B4GALNT3 C11orf24 C14orf39 C1orf134 CDK6 CRIPAK DOCK9 EBPL ERI1 FAM66A FGFRL1 FHL3 GAL GHR HHIP-AS1 IBSP IGHMBP2 LOC338758 MYH7B PPP1R3B RP11-20I20.4 RP13-514E23.2 SLCO2B1 SUPT3H ZNF408
Trunk fat percentage 1.15 10 5 15.2 0.12 7.5e-01 AMT CERS5 CPED1 CTD-2540B15.12 DNAH10 HDAC5 HMGB1P31 RERE SPTBN1 WNT2B
Hand grip strength (right) 1.59 4 3 9.1 -0.82 1.2e-02 C7orf58 CRIPAK DNAH10 RP11-20I20.4
Current tobacco smoking 1.25 1 0 0.0 0.00 1.0e+00 FAM66A
Maternal smoking around birth 1.09 1 0 0.0 0.00 1.0e+00 MARK3
Fed-up feelings 1.28 5 3 9.1 -0.99 4.5e-04 AF131215.9 ERI1 FAM66A PPP1R3B ZNF408
Relative age voice broke 0.85 1 0 0.0 0.00 1.0e+00 AMT
Age when periods started (menarche) 1.16 3 1 3.0 0.00 1.0e+00 L3MBTL2 RP11-500G22.2 TIPARP
Heel bone mineral density (BMD) T-score, automated (left) 29.99 116 99 300.0 1.00 4.8e-161 ABCB8 AC004549.6 AC093110.3 ACYP2 AF131215.9 ALG12 AMT AP4E1 B4GALNT3 BMP4 C11orf24 C11orf58 C14orf39 C1orf134 C6orf97 C7orf58 CADM1 CAPZB CASP9 CBL CCDC170 CD109 CD44 CDK6 CERS5 CPED1 CRIPAK CTCF CTD-2540B15.12 DNAH10 DOCK9 DOCK9-AS2 EBPL ECHDC1 EML6 EPDR1 ERI1 ESR1 EYA4 FADS2 FAM210A FAM3C FAM66A FDFT1 FGFRL1 FHL3 FZD7 GAL GHR GPATCH1 GREM2 HDAC5 HHIP-AS1 HMGB1P31 HSD17B13 IBSP IDUA IGHMBP2 IL18 INSIG2 KLHL17 KREMEN1 L3MBTL2 LEKR1 LGR4 LIN7C LINC00326 LINC00886 LOC338758 MARK3 MEOX2 METTL15P1 MMAA MS4A6A MYH7B PKD2 PKDCC PPP1R3B PTPDC1 RASSF8 RERE RHPN2 RMND1 RP11-20I20.4 RP11-356J5.12 RP11-500G22.2 RP11-867G23.1 RP11-981G7.6 RP13-514E23.2 RP4-800G7.2 RPS12 RSPO3 SEPT5 SERTAD2 SGK223 SIPA1 SKIV2L2 SLC30A10 SLC8A1 SLCO2B1 SPP1 SPTBN1 SRP54 SUPT3H TIPARP TMEM8A TOMM22 TPCN2 TTC28 VNN2 WARS2 WNT2B XKR9 ZNF169 ZNF408 ZNF774
High blood pressure 1.52 9 4 12.1 0.39 3.0e-01 AF131215.9 ERI1 FAM66A KREMEN1 RP11-981G7.6 RP13-514E23.2 SIPA1 WNT2B ZNF408
Hayfever, allergic rhinitis or eczema 1.03 2 2 6.1 0.00 1.0e+00 RERE ZNF774
Medication: Levothyroxine sodium 1.30 2 1 3.0 0.00 1.0e+00 ERI1 FADS2
Sitting height 2.14 28 18 54.5 0.22 2.1e-01 AP4E1 B4GALNT3 C14orf39 CAPZB CD109 CDK6 CRIPAK CTCF DOCK9 EBPL EPDR1 ERI1 FHL3 GAL HHIP-AS1 HMGB1P31 HSD17B13 IBSP KREMEN1 MYH7B PPP1R3B RP11-20I20.4 RSPO3 SLCO2B1 SUPT3H TIPARP ZNF169 ZNF408
Chronic bronchitis/emphysema (father) 0.99 1 0 0.0 0.00 1.0e+00 HHIP-AS1
Body mass index (BMI) 1.21 11 6 18.2 0.83 1.7e-03 AF131215.9 AMT CADM1 DNAH10 ERI1 FAM66A IGHMBP2 MARK3 PPP1R3B RP11-981G7.6 SGK223
Impedance of leg (left) 1.73 19 11 33.3 -0.40 8.9e-02 ABCB8 AF131215.9 C11orf24 C1orf134 CADM1 CDK6 ERI1 FAM66A FDFT1 GAL GHR IBSP IGHMBP2 INSIG2 L3MBTL2 MARK3 PPP1R3B WARS2 WNT2B
Leg predicted mass (left) 2.01 27 16 48.5 0.31 9.5e-02 ABCB8 AF131215.9 AP4E1 B4GALNT3 C11orf24 C14orf39 C1orf134 CDK6 CRIPAK DOCK9 EBPL ERI1 FAM66A FHL3 GAL GHR HHIP-AS1 IBSP IGHMBP2 LOC338758 MYH7B PPP1R3B RP11-20I20.4 RP13-514E23.2 SLCO2B1 SUPT3H ZNF408
Trunk fat mass 1.23 10 6 18.2 0.27 4.5e-01 AMT CDK6 CERS5 CTD-2540B15.12 DNAH10 HDAC5 HMGB1P31 PPP1R3B RERE WNT2B
Waist circumference 1.14 9 2 6.1 0.39 3.0e-01 ABCB8 AMT CADM1 CDK6 HMGB1P31 LINC00886 MARK3 RSPO3 TIPARP
Past tobacco smoking 0.92 1 0 0.0 0.00 1.0e+00 MYH7B
Alcohol usually taken with meals 1.09 1 0 0.0 0.00 1.0e+00 TPCN2
Nervous feelings 1.94 5 4 12.1 -0.98 4.4e-03 AF131215.9 ERI1 FAM66A PPP1R3B RP11-981G7.6
Hearing difficulty/problems with background noise 1.33 1 0 0.0 0.00 1.0e+00 ZNF408
Forced vital capacity (FVC) 1.42 12 6 18.2 0.31 2.4e-01 CDK6 CRIPAK EBPL FGFRL1 FHL3 GAL HHIP-AS1 PKD2 PTPDC1 RP11-20I20.4 RSPO3 ZNF169
Allergy 1.06 3 1 3.0 0.00 1.0e+00 FADS2 RERE ZNF774
Fluid intelligence score 0.88 1 0 0.0 0.00 1.0e+00 AMT
Illnesses of siblings 1.25 1 0 0.0 0.00 1.0e+00 CADM1
Neuroticism score 1.80 5 4 12.1 -0.98 3.0e-03 AF131215.9 ERI1 FAM66A PPP1R3B ZNF408
Weight 1.62 21 5 15.2 0.46 2.7e-02 AF131215.9 AMT B4GALNT3 C11orf24 C14orf39 CBL CDK6 CERS5 CRIPAK DOCK9 ERI1 FAM66A GAL GHR HHIP-AS1 HMGB1P31 IBSP IGHMBP2 MYH7B PPP1R3B WNT2B
Impedance of arm (right) 2.14 28 20 60.6 -0.19 2.8e-01 ABCB8 AF131215.9 C11orf24 CADM1 CRIPAK CTD-2540B15.12 DNAH10 ERI1 FAM66A FDFT1 FZD7 GHR IBSP IGHMBP2 KREMEN1 L3MBTL2 LINC00886 MARK3 METTL15P1 MYH7B PPP1R3B RP11-20I20.4 RP11-981G7.6 SGK223 SPTBN1 TIPARP WARS2 WNT2B
Arm fat percentage (right) 1.07 9 3 9.1 0.96 5.5e-05 AMT CERS5 DNAH10 ERI1 FAM66A HDAC5 HMGB1P31 MARK3 PPP1R3B
Trunk fat-free mass 2.37 27 19 57.6 0.26 1.5e-01 ABCB8 AF131215.9 B4GALNT3 C11orf24 C14orf39 CAPZB CDK6 CRIPAK DNAH10 DOCK9 EBPL FAM66A FGFRL1 FHL3 GAL GHR HHIP-AS1 HSD17B13 IBSP IGHMBP2 MYH7B RP11-20I20.4 RP13-514E23.2 SUPT3H ZNF169 ZNF408 ZNF774
Hip circumference 1.42 15 6 18.2 0.04 8.9e-01 AF131215.9 AP4E1 CBL CDK6 DNAH10 ERI1 FAM66A HHIP-AS1 HMGB1P31 MYH7B PPP1R3B RSPO3 TOMM22 TPCN2 WARS2
Father's age at death 1.47 1 0 0.0 0.00 1.0e+00 ERI1
Worrier / anxious feelings 1.91 4 4 12.1 -0.99 1.1e-02 AF131215.9 ERI1 FAM66A PPP1R3B
Frequency of tiredness / lethargy in last 2 weeks 1.15 2 0 0.0 0.00 1.0e+00 AMT ZNF408
Number of live births 0.92 1 1 3.0 0.00 1.0e+00 FADS2
Forced expiratory volume in 1-second (FEV1) 1.72 12 4 12.1 0.08 7.7e-01 CDK6 CRIPAK EBPL ERI1 FAM66A FHL3 GAL HHIP-AS1 PKD2 RP11-20I20.4 RSPO3 ZNF169
Pulse rate 1.59 3 1 3.0 0.00 1.0e+00 AMT FADS2 TOMM22
Qualifications: A levels/AS levels or equivalent 0.92 3 0 0.0 0.00 1.0e+00 AMT FZD7 SGK223
Mouth/teeth dental problems: Dentures 1.07 1 0 0.0 0.00 1.0e+00 ERI1
Asthma 1.20 2 2 6.1 0.00 1.0e+00 FADS2 RERE
Forced expiratory volume in 1-second (FEV1), Best measure 1.69 11 2 6.1 -0.31 2.6e-01 CDK6 CRIPAK EBPL ERI1 FAM66A FHL3 GAL HHIP-AS1 PTPDC1 RP11-20I20.4 ZNF169
Impedance of arm (left) 1.91 28 12 36.4 -0.20 3.0e-01 ABCB8 AF131215.9 C11orf24 CADM1 CRIPAK CTD-2540B15.12 DNAH10 ERI1 FAM66A FDFT1 FZD7 GHR IBSP IGHMBP2 KREMEN1 L3MBTL2 LINC00886 MARK3 MYH7B PPP1R3B RP11-20I20.4 RP11-981G7.6 SGK223 SPTBN1 SRP54 TIPARP WARS2 WNT2B
Arm fat mass (right) 1.17 12 6 18.2 0.67 1.7e-02 AF131215.9 AMT CADM1 CDK6 CERS5 DNAH10 ERI1 FAM66A HDAC5 HMGB1P31 MARK3 PPP1R3B
Trunk predicted mass 2.35 27 19 57.6 0.24 1.8e-01 ABCB8 AF131215.9 B4GALNT3 C11orf24 C14orf39 CAPZB CDK6 CRIPAK DNAH10 DOCK9 EBPL FAM66A FGFRL1 FHL3 GAL GHR HHIP-AS1 IBSP IGHMBP2 MYH7B RP11-20I20.4 RP13-514E23.2 SLCO2B1 SUPT3H ZNF169 ZNF408 ZNF774
Standing height 2.14 39 25 75.8 -0.02 9.1e-01 AP4E1 B4GALNT3 C14orf39 C1orf134 C7orf58 CAPZB CDK6 CRIPAK CTD-2540B15.12 DNAH10 DOCK9 EBPL EPDR1 ERI1 FADS2 FAM66A FGFRL1 FHL3 GAL GHR HHIP-AS1 HSD17B13 LIN7C LINC00886 MARK3 MYH7B RP11-20I20.4 RP13-514E23.2 RP4-800G7.2 SGK223 SLCO2B1 SUPT3H TIPARP TOMM22 TPCN2 WNT2B ZNF169 ZNF408 ZNF774
Tense / 'highly strung' 1.85 5 3 9.1 -0.70 1.9e-01 AF131215.9 ERI1 FAM66A PPP1R3B RERE
Hair/balding pattern: Pattern 4 1.55 6 3 9.1 -0.14 7.9e-01 CTCF FADS2 MYH7B SUPT3H WARS2 ZNF774
Birth weight of first child 1.33 3 0 0.0 0.00 1.0e+00 TIPARP ZNF169 ZNF774
Peak expiratory flow (PEF) 1.87 5 3 9.1 -0.82 9.2e-02 BMP4 ERI1 FAM66A HHIP-AS1 RP11-981G7.6
Headache pain in last month 1.03 1 0 0.0 0.00 1.0e+00 PPP1R3B
Gout (self-reported) 1.17 2 1 3.0 0.00 1.0e+00 PKD2 SIPA1
Hypothyroidism/myxoedema (self-reported) 1.60 7 2 6.1 -1.00 5.3e-07 AF131215.9 ERI1 FADS2 FAM66A PPP1R3B RP11-981G7.6 SGK223
Birth weight 1.91 4 2 6.1 0.73 2.7e-01 CDK6 KREMEN1 LINC00886 TIPARP
Chronic bronchitis/emphysema (mother) 1.22 1 0 0.0 0.00 1.0e+00 HHIP-AS1
Forced vital capacity (FVC), Best measure 1.41 10 5 15.2 -0.26 3.8e-01 CDK6 CRIPAK EBPL FHL3 GAL HHIP-AS1 PTPDC1 RP11-20I20.4 ZNF169 ZNF408
Body fat percentage 1.10 10 5 15.2 0.30 3.9e-01 AMT CERS5 DNAH10 HDAC5 HMGB1P31 MARK3 PPP1R3B RERE SPTBN1 WNT2B
Leg fat percentage (right) 1.10 11 3 9.1 0.25 4.6e-01 AMT CERS5 DNAH10 ERI1 EYA4 LGR4 PPP1R3B RERE RP11-981G7.6 SGK223 WNT2B
Arm fat-free mass (right) 2.23 24 16 48.5 0.39 3.5e-02 ABCB8 AF131215.9 B4GALNT3 C11orf24 C14orf39 CDK6 CRIPAK DNAH10 DOCK9 EBPL ERI1 FAM66A FGFRL1 FHL3 GAL GHR HHIP-AS1 IBSP IGHMBP2 MYH7B PPP1R3B RP11-20I20.4 RP13-514E23.2 SUPT3H
Comparative body size at age 10 1.60 12 8 24.2 0.46 1.3e-01 AF131215.9 C11orf24 CADM1 CERS5 ERI1 FAM66A FDFT1 IGHMBP2 L3MBTL2 PPP1R3B SIPA1 WNT2B
Worry too long after embarrassment 1.26 3 2 6.1 0.00 1.0e+00 AF131215.9 ERI1 FAM66A
Wheeze or whistling in the chest in last year 1.13 1 0 0.0 0.00 1.0e+00 RERE
Age at first live birth 0.84 1 0 0.0 0.00 1.0e+00 LOC338758
Qualifications: College or University degree 0.66 4 1 3.0 0.42 5.8e-01 AMT CADM1 MYH7B RERE
Emphysema/chronic bronchitis 1.07 1 0 0.0 0.00 1.0e+00 ERI1
Medication: Blood pressure 1.15 2 0 0.0 0.00 1.0e+00 ERI1 SIPA1
Angina (self-reported) 1.07 1 0 0.0 0.00 1.0e+00 CADM1
Medication: Allopurinol 1.15 1 1 3.0 0.00 1.0e+00 PKD2
Mean time to correctly identify matches 0.92 1 1 3.0 0.00 1.0e+00 ZNF408
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.17 1 0 0.0 0.00 1.0e+00 RP11-981G7.6
Whole body fat mass 1.17 11 4 12.1 0.37 2.6e-01 AMT CDK6 CERS5 DNAH10 ERI1 HDAC5 HMGB1P31 MARK3 PPP1R3B RERE WNT2B
Leg fat mass (right) 1.23 15 4 12.1 0.32 2.5e-01 AF131215.9 AMT CADM1 CDK6 CERS5 DNAH10 ERI1 FAM66A HMGB1P31 LGR4 MARK3 PPP1R3B RERE RP11-981G7.6 WNT2B
Arm predicted mass (right) 2.27 24 16 48.5 0.40 3.0e-02 ABCB8 AF131215.9 B4GALNT3 C11orf24 C14orf39 CDK6 CRIPAK DNAH10 DOCK9 EBPL ERI1 FAM66A FGFRL1 FHL3 GAL GHR HHIP-AS1 IBSP IGHMBP2 MYH7B PPP1R3B RP11-20I20.4 RP13-514E23.2 SUPT3H
Pulse rate, automated reading 1.82 9 5 15.2 0.33 3.8e-01 AMT CRIPAK FADS2 IGHMBP2 LEKR1 METTL15P1 MYH7B SERTAD2 TOMM22
Alcohol intake frequency. 0.73 2 0 0.0 0.00 1.0e+00 AMT TOMM22
Comparative height size at age 10 1.78 20 13 39.4 -0.05 8.0e-01 B4GALNT3 C14orf39 CAPZB CDK6 CRIPAK DNAH10 EBPL FGFRL1 FHL3 GAL HHIP-AS1 MARK3 RP11-20I20.4 SLCO2B1 SUPT3H WARS2 WNT2B ZNF169 ZNF408 ZNF774
Suffer from 'nerves' 1.44 4 0 0.0 -1.00 2.7e-03 AF131215.9 ERI1 FAM66A ZNF408
Overall health rating 1.10 1 0 0.0 0.00 1.0e+00 LOC338758
Chest pain or discomfort 1.03 1 0 0.0 0.00 1.0e+00 CADM1
Hypertension (Self-reported) 1.45 8 4 12.1 0.55 1.5e-01 AF131215.9 AP4E1 ERI1 FAM66A KREMEN1 RP11-981G7.6 RP13-514E23.2 SIPA1
Illnesses of father: Heart disease 1.12 1 0 0.0 0.00 1.0e+00 DNAH10
Forced expiratory volume in 1-second (FEV1), predicted 1.66 4 1 3.0 -0.72 2.8e-01 B4GALNT3 CDK6 FHL3 HHIP-AS1
Whole body fat-free mass 2.26 26 19 57.6 0.38 3.4e-02 ABCB8 AF131215.9 B4GALNT3 C11orf24 C14orf39 C1orf134 CDK6 CRIPAK DNAH10 DOCK9 EBPL ERI1 FAM66A FGFRL1 FHL3 GAL GHR HHIP-AS1 IBSP IGHMBP2 MYH7B PPP1R3B RP11-20I20.4 RP13-514E23.2 SUPT3H ZNF408
Leg fat-free mass (right) 2.06 26 15 45.5 0.34 6.6e-02 ABCB8 AF131215.9 AP4E1 B4GALNT3 C11orf24 C14orf39 C1orf134 CDK6 CRIPAK DOCK9 EBPL ERI1 FAM66A FHL3 GAL GHR HHIP-AS1 IBSP IGHMBP2 MYH7B PPP1R3B RP11-20I20.4 RP13-514E23.2 SLCO2B1 SUPT3H ZNF408
Arm fat percentage (left) 1.10 10 3 9.1 0.74 1.4e-02 AMT CADM1 CERS5 DNAH10 ERI1 FAM66A HDAC5 MARK3 PPP1R3B RERE
Mood swings 1.33 3 1 3.0 0.00 1.0e+00 AF131215.9 ERI1 FAM66A
Medication for cholesterol 1.38 1 0 0.0 0.00 1.0e+00 CADM1
Asthma (self-reported) 1.22 2 2 6.1 0.00 1.0e+00 FADS2 RERE
Osteoporosis (self-reported) 3.87 6 5 15.2 -0.67 1.4e-01 CPED1 DNAH10 GAL GREM2 LIN7C SPP1
Smoking status: Current 1.29 1 0 0.0 0.00 1.0e+00 FAM66A
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.22 2 1 3.0 0.00 1.0e+00 FAM66A HHIP-AS1
Whole body water mass 2.25 26 19 57.6 0.38 3.0e-02 ABCB8 AF131215.9 B4GALNT3 C11orf24 C14orf39 C1orf134 CDK6 CRIPAK DNAH10 DOCK9 EBPL ERI1 FAM66A FGFRL1 FHL3 GAL GHR HHIP-AS1 IBSP IGHMBP2 MYH7B PPP1R3B RP11-20I20.4 RP13-514E23.2 SUPT3H ZNF408
Leg predicted mass (right) 2.05 26 15 45.5 0.34 6.7e-02 ABCB8 AF131215.9 AP4E1 B4GALNT3 C11orf24 C14orf39 C1orf134 CDK6 CRIPAK DOCK9 EBPL ERI1 FAM66A FHL3 GAL GHR HHIP-AS1 IBSP IGHMBP2 MYH7B PPP1R3B RP11-20I20.4 RP13-514E23.2 SLCO2B1 SUPT3H ZNF408
Arm fat mass (left) 1.19 13 6 18.2 0.68 9.9e-03 AF131215.9 AMT CADM1 CBL CDK6 CERS5 DNAH10 ERI1 FAM66A HDAC5 HMGB1P31 MARK3 PPP1R3B
Miserableness 1.52 6 4 12.1 -1.00 1.2e-06 AF131215.9 ERI1 FAM66A PPP1R3B RP11-981G7.6 ZNF408
Guilty feelings 1.35 3 0 0.0 0.00 1.0e+00 AF131215.9 ERI1 FAM66A
Hearing aid user 1.44 2 1 3.0 0.00 1.0e+00 AC093110.3 SPTBN1
Eye problems/disorders: Glaucoma 1.58 1 0 0.0 0.00 1.0e+00 C14orf39
Medication: Blood pressure 1.49 5 1 3.0 1.00 4.7e-05 AF131215.9 ERI1 FAM66A SIPA1 WNT2B
Medication: Bendroflumethiazide 1.65 4 0 0.0 1.00 5.1e-04 AF131215.9 ERI1 FAM66A RP11-981G7.6
Illnesses of father: High blood pressure 1.28 1 0 0.0 0.00 1.0e+00 RP13-514E23.2
Basal metabolic rate 2.13 28 19 57.6 0.40 2.0e-02 ABCB8 AF131215.9 B4GALNT3 C11orf24 C14orf39 C1orf134 CBL CDK6 CRIPAK DOCK9 EBPL ERI1 FAM66A FGFRL1 FHL3 GAL GHR HHIP-AS1 HMGB1P31 IBSP IGHMBP2 MYH7B PPP1R3B RP11-20I20.4 RP13-514E23.2 SLCO2B1 SUPT3H ZNF408
Leg fat percentage (left) 1.09 12 4 12.1 0.47 1.2e-01 AMT CERS5 DNAH10 ERI1 HMGB1P31 LGR4 MARK3 PPP1R3B RERE RP11-981G7.6 SGK223 WNT2B
Arm fat-free mass (left) 2.19 25 15 45.5 0.39 2.9e-02 ABCB8 AF131215.9 B4GALNT3 C11orf24 C14orf39 CBL CDK6 CRIPAK DNAH10 DOCK9 EBPL ERI1 FAM66A FGFRL1 FHL3 GAL GHR HHIP-AS1 IBSP IGHMBP2 MYH7B PPP1R3B RP11-20I20.4 RP13-514E23.2 SUPT3H
Average weekly beer plus cider intake 1.15 2 0 0.0 0.00 1.0e+00 AF131215.9 ERI1
Irritability 1.65 4 3 9.1 -0.99 9.3e-03 AF131215.9 ERI1 FAM66A PPP1R3B
Fractured/broken bones in last 5 years 5.24 11 4 12.1 -0.99 1.6e-14 C7orf58 CPED1 CRIPAK FAM3C FGFRL1 HDAC5 IGHMBP2 LOC338758 RP11-20I20.4 RSPO3 TPCN2
Diastolic blood pressure, automated reading 1.72 13 6 18.2 0.62 2.5e-02 AF131215.9 AMT EML6 ERI1 FAM66A FDFT1 PPP1R3B RERE RP11-981G7.6 RP13-514E23.2 SGK223 SIPA1 WNT2B
Myopia 1.26 2 0 0.0 0.00 1.0e+00 BMP4 FADS2
Vascular/heart problems diagnosed by doctor 1.37 7 3 9.1 -0.44 3.2e-01 AF131215.9 ERI1 FAM66A KREMEN1 MARK3 SIPA1 ZNF408
Cholesterol lowering medication 1.04 2 0 0.0 0.00 1.0e+00 C1orf134 DNAH10
Supplements: Calcium 1.81 1 0 0.0 0.00 1.0e+00 LOC338758
Impedance of whole body 1.94 25 14 42.4 -0.27 1.6e-01 ABCB8 AF131215.9 C11orf24 CADM1 CRIPAK CTD-2540B15.12 DNAH10 ERI1 FAM66A FDFT1 FZD7 GHR IBSP IGHMBP2 INSIG2 L3MBTL2 LINC00886 MARK3 MYH7B PPP1R3B RP11-20I20.4 RP11-981G7.6 SGK223 WARS2 WNT2B
Leg fat mass (left) 1.25 14 5 15.2 0.40 1.5e-01 AF131215.9 AMT CADM1 CBL CDK6 CERS5 DNAH10 ERI1 FAM66A HMGB1P31 MARK3 PPP1R3B RERE WNT2B
Arm predicted mass (left) 2.21 26 16 48.5 0.38 3.7e-02 ABCB8 AF131215.9 B4GALNT3 C11orf24 C14orf39 CBL CDK6 CRIPAK DNAH10 DOCK9 EBPL ERI1 FAM66A FGFRL1 FHL3 GAL GHR HHIP-AS1 HMGB1P31 IBSP IGHMBP2 MYH7B PPP1R3B RP11-20I20.4 RP13-514E23.2 SUPT3H

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 23 0.659 2.38
GTEx Adipose Visceral Omentum 18 0.884 2.51
GTEx Adrenal Gland 6 0.412 2.20
GTEx Artery Aorta 26 0.873 2.45
GTEx Artery Coronary 5 0.423 2.35
GTEx Artery Tibial 34 0.904 2.66
GTEx Brain Caudate basal ganglia 7 0.761 2.37
GTEx Brain Cerebellar Hemisphere 10 0.672 2.35
GTEx Brain Cerebellum 10 0.505 2.24
GTEx Brain Cortex 8 0.773 2.46
GTEx Brain Frontal Cortex BA9 5 0.541 2.39
GTEx Brain Hippocampus 2 0.382 2.59
GTEx Brain Hypothalamus 2 0.339 2.27
GTEx Brain Nucleus accumbens basal ganglia 4 0.462 2.17
GTEx Brain Putamen basal ganglia 5 0.801 2.38
GTEx Breast Mammary Tissue 12 0.608 2.51
GTEx Breast Mammary Tissue (Male) 11 0.922 2.30
GTEx Breast Mammary Tissue (Female) 9 0.547 2.34
GTEx Cells EBV-transformed lymphocytes 8 0.562 2.35
GTEx Cells Transformed fibroblasts 21 0.500 2.31
GTEx Colon Sigmoid 5 0.342 2.27
GTEx Colon Transverse 17 0.824 2.22
GTEx Esophagus Gastroesophageal Junction 12 0.830 2.37
GTEx Esophagus Mucosa 22 0.663 2.25
GTEx Esophagus Muscularis 22 0.681 2.31
GTEx Heart Atrial Appendage 10 0.633 2.29
GTEx Heart Left Ventricle 11 0.719 2.39
GTEx Liver 3 0.418 2.09
GTEx Lung 21 0.731 2.39
GTEx Muscle Skeletal 13 0.450 2.06
GTEx Nerve Tibial 31 0.717 2.36
GTEx Ovary 4 0.441 2.46
GTEx Pancreas 19 1.164 2.74
GTEx Pituitary 5 0.448 2.29
GTEx Prostate 8 0.958 2.50
GTEx Skin Not Sun Exposed Suprapubic 20 0.813 2.47
GTEx Skin Sun Exposed Lower leg 25 0.687 2.49
GTEx Small Intestine Terminal Ileum 2 0.434 2.48
GTEx Spleen 9 0.638 2.41
GTEx Stomach 9 0.619 2.31
GTEx Testis 24 0.761 2.32
GTEx Thyroid 24 0.600 2.35
GTEx Uterus 5 0.882 2.58
GTEx Vagina 5 0.787 2.40
GTEx Whole Blood 14 0.702 2.23
METSIM Adipose 31 0.672 2.22
NTR Blood 23 0.958 2.38
ROSMAP Brain Pre-frontal Cortex 43 0.979 2.48
YFS Blood 20 0.433 1.97
CommonMind Brain Pre-frontal Cortex 33 0.614 2.22
TCGA Breast Tumor 8 1.043 2.62
TCGA Breast Normal 21 0.499 2.02
TCGA Ovarian Tumor 22 0.753 2.09
TCGA Prostate Tumor 30 0.867 2.22