Hub : Genes

ABCA10

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2010	0.0400	1.1e-16	0.125	0.173	0.173	0.175	0.168	5.4e-15	1.3e-20	1.5e-20	8.8e-21	5.8e-20
2	GTEx	Esophagus Muscularis	0.1200	0.0500	8.8e-03	0.067	NA	0.045	NA	0.033	6.7e-05	NA	1.0e-03	NA	4.1e-03
3	GTEx	Heart Atrial Appendage	0.1800	0.0730	5.7e-03	0.020	NA	0.027	NA	0.025	4.2e-02	NA	2.1e-02	NA	2.7e-02
4	GTEx	Testis	0.3460	0.0730	9.1e-08	0.227	NA	0.170	NA	0.216	1.9e-10	NA	5.3e-08	NA	5.8e-10
5	METSIM	Adipose	0.0570	0.0202	1.5e-04	0.027	0.032	0.020	0.035	0.039	5.9e-05	1.2e-05	4.3e-04	5.5e-06	1.3e-06
6	TCGA	Breast Invasive Carcinoma	0.0127	0.0081	3.7e-03	0.023	0.012	0.019	NA	0.021	1.2e-05	1.5e-03	5.8e-05	NA	3.5e-05
7	TCGA	Brain Lower Grade Glioma	0.0455	0.0244	1.1e-03	0.019	0.025	0.021	NA	0.017	2.8e-03	7.1e-04	1.9e-03	NA	4.6e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.2	0.3	1.5	-1.2	-0.4	0.1	-0.2	-0.5	0.2	-0.3
Bipolar Disorder or Schizophrenia	0.2	0.4	1.2	-0.6	0.3	-0.9	-0.8	-0.1	-0.1	-1.1
Depressed Affect (Nagel 2018)	0.7	1.4	3.8	1.9	-0.9	-0.7	-1.3	-0.9	-1.4	-0.4
Depression (Nagel 2018)	0.2	0.3	0.6	0.4	-0.4	-0.5	-0.7	-0.2	-0.7	0.4
Intelligence (Savage-Jansen 2018)	1.2	3.6	7.6	1.8	-1.6	-1.1	-2.8	-1.9	-2.0	-1.7
Neuroticism (Nagel 2018)	1.1	2.6	6.2	2.5	-1.7	-1.7	-1.2	-1.6	-1.2	-0.9
Schizophrenia (2018)	0.3	0.6	1.4	0.2	0.7	-1.2	-0.8	0.2	-0.2	-1.2
Schizophrenia vs Biploar Disorder	1.0	1.3	5.3	2.3	0.7	-0.0	-1.0	1.1	-0.9	-0.5
Worry (Nagel 2018)	2.6	5.4	9.4	3.1	-2.3	-2.6	-2.1	-2.1	-1.9	-2.0
Alzheimer’s Disease (in mother)	0.6	0.7	2.1	-0.4	0.4	1.0	-0.7	0.8	-0.5	-1.4
Alzheimer’s Disease (in father)	1.4	1.5	3.5	-0.2	-0.5	-1.9	-1.6	-1.2	-0.7	-1.5
Alzheimer’s Disease (including proxy)	0.3	0.5	1.3	-0.4	-0.1	-0.8	-1.0	-0.1	-0.5	-1.1
Crohns Disease (2017)	0.6	1.2	2.6	0.5	-0.1	-0.8	-1.6	-0.1	-1.6	-1.5
Irritable Bowel Disease (IBD)	1.7	4.0	8.0	1.5	-1.2	-2.2	-2.8	-1.6	-2.3	-2.0
Ulcerative Colitis (UC)	2.4	4.5	6.7	1.6	-1.9	-2.4	-2.6	-2.3	-2.0	-1.8
Major Depression (MDD)	1.3	1.6	3.7	0.5	-1.0	-1.3	-1.7	-0.8	-1.9	-1.1
Reaction Time	0.2	0.4	1.2	1.1	-0.2	-0.2	-0.5	-1.1	-0.3	0.4
Verbal and Numeric Reasoning (VNR)	0.4	1.0	3.0	1.0	0.1	-0.1	-1.7	-0.9	-0.7	-1.3
Breast Cancer	0.4	1.1	2.6	-1.0	-1.6	-1.3	0.8	-1.0	0.7	0.5
Ovarian Cancer	1.1	1.4	2.9	-0.9	1.4	-0.4	1.7	1.1	1.7	0.3
Prostate Cancer	0.3	0.5	1.8	1.3	0.5	0.3	-0.1	-0.6	-0.6	-0.7
Age at First Birth	0.7	1.0	2.9	0.5	-0.1	-0.4	-0.7	-1.7	-1.6	-0.9
Bipolar Disorder (2011)	0.7	0.6	1.4	-0.8	-0.5	-1.2	-0.9	-0.9	-0.4	-0.6
Body Mass Index (BMI) (2010)	0.1	0.2	0.4	-0.4	-0.2	-0.4	-0.6	0.3	-0.5	-0.6
Coronary Artery Disease (CAD)	0.4	0.4	2.7	-0.0	-1.6	0.5	0.2	-0.0	-0.0	0.2
Crohns Disease (2012)	0.7	1.1	2.5	-0.1	-0.6	-1.6	-1.4	-0.6	-1.2	-1.0
Mean Putamen Volume	0.4	0.5	2.6	0.0	0.7	1.6	-0.1	0.3	0.3	0.1
Fasting Glucose	0.9	1.0	3.5	-1.0	1.0	1.9	0.8	0.8	0.4	0.3
HbA1C	0.3	0.3	0.5	-0.6	0.7	0.5	0.3	0.0	0.6	-0.7
HDL Cholesterol	0.9	1.6	4.0	1.5	1.7	2.0	-0.7	0.2	-1.0	-0.5
LDL Cholesterol	0.3	0.5	1.3	1.1	0.4	0.4	0.9	1.0	-0.3	-0.0
Lupus	0.6	0.8	3.0	0.2	0.0	-0.7	1.4	-0.2	1.7	0.7
Neuroticism (2016)	1.6	2.4	5.2	1.9	-1.8	-2.0	0.1	-2.3	-0.3	0.3
Primary Biliary Cirrhosis	3.4	4.8	16.6	0.7	-2.9	-1.4	-1.6	-4.1	-1.5	-1.2
Rheumatoid Arthritis	0.7	1.0	2.7	1.6	-0.2	-1.0	-1.2	-0.5	-0.7	-0.8
Schizophrenia (2014)	0.5	1.2	3.1	-0.1	0.5	-1.1	-1.6	0.2	-1.0	-1.8
Triglycerides	0.5	0.8	2.8	-1.7	-1.0	1.0	0.3	0.5	0.6	0.2
Type 2 Diabetes (T2D) (2012)	0.8	0.9	3.0	-0.4	-0.7	-0.5	1.7	-0.8	1.2	0.6
Ulcerative Colitis	2.5	3.7	5.9	1.7	-2.0	-1.9	-2.4	-2.3	-1.6	-1.1
Blood Eosinophil Count	0.1	0.7	2.4	1.6	-0.5	0.6	-0.8	-0.6	-0.9	0.1
Blood Platelet Count	0.5	5.3	15.4	1.3	0.0	2.0	-3.9	-0.4	-2.6	-3.0
Blood Red Count	0.1	0.7	2.9	1.7	0.8	0.8	0.1	0.8	-0.0	0.5
Blood White Count	1.7	12.3	30.7	2.7	-1.4	0.1	-5.5	-2.6	-4.5	-4.4
Heel T-Score	0.5	3.9	15.1	-1.2	3.9	1.8	1.5	2.2	0.1	-0.4
BMI	0.7	4.0	7.6	2.5	-1.0	0.3	-2.6	-1.3	-2.8	-2.1
Height	0.2	4.3	11.0	-1.7	-1.0	-0.3	3.3	-0.5	3.2	2.3
Waist Hip Ratio (WHR)	1.0	4.6	8.8	-2.9	0.2	-1.5	2.4	1.3	3.0	2.3
Systolic Blood Pressure	0.3	1.5	4.7	2.2	-0.1	-0.3	0.5	2.0	1.3	0.2
Smoking Status	0.4	0.9	2.4	-1.0	-1.4	-0.2	-0.7	-0.8	0.2	-1.6
Allergy or Eczema	1.2	3.2	6.4	1.9	1.5	-0.6	-2.5	0.1	-2.4	-2.0
Cardiovascular Disease	0.5	1.7	9.4	3.1	0.3	-1.3	-0.5	0.0	-0.5	0.7
Hypothyroidism (self reported)	0.2	0.4	1.1	1.1	-0.6	0.6	-0.1	0.1	-0.6	-0.7
Respiratory disease	0.2	0.4	1.7	-0.1	0.3	0.1	-0.5	0.4	-1.3	-0.8
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.0	1.4	0.3	-0.7	-1.2	0.7	-1.4	-1.0
Lung FEV1/FVC ratio	0.8	4.1	11.8	-1.7	0.9	-0.6	3.4	0.1	2.4	2.7
Lung FVC	0.2	1.1	2.0	0.4	-1.3	-0.0	-1.2	-0.6	-1.3	-1.4
Neuroticism	1.2	3.0	4.6	2.0	-2.0	-1.8	-1.6	-2.1	-1.4	-0.8
Chronotype (morning person)	0.4	1.0	2.2	0.8	-1.2	0.1	-0.7	-1.5	-1.3	-0.6
Hair Pigment	0.0	0.4	1.9	0.7	-1.4	-0.4	0.1	0.0	0.1	0.4
Tanning	0.1	1.3	2.4	-0.6	-1.1	0.4	-1.2	-1.6	-1.4	-1.1
Hand grip strength (left)	0.8	2.0	4.9	0.4	-1.4	-1.6	-0.7	-2.2	-1.8	-1.0
Number of treatments/medications taken	0.2	0.3	1.2	0.3	0.3	-0.7	0.5	0.3	-0.1	1.1
Average weekly spirits intake	1.0	1.3	2.3	1.0	-1.1	-0.1	-1.5	-1.2	-1.2	-1.1
Sensitivity / hurt feelings	0.3	0.6	1.6	1.3	-0.6	0.7	-0.7	-0.1	-0.8	-0.6
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.2	0.7	-1.5	-1.0	-1.2	-1.0	-0.8	-0.2
Hearing difficulty/problems: Yes	0.9	1.4	3.7	-1.9	-1.9	-0.9	0.3	-0.9	0.7	0.4
Relative age of first facial hair	0.5	1.0	4.2	2.1	0.5	-1.0	1.1	0.3	0.1	0.5
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	3.2	0.6	-1.8	-0.9	-0.8	-0.5	-1.3	-0.4
Ever used hormone-replacement therapy (HRT)	0.7	0.8	2.2	-0.6	1.5	1.2	0.2	1.2	-0.4	-0.4
Ever had hysterectomy (womb removed)	0.3	0.4	0.8	-0.7	-0.2	0.4	0.7	0.9	0.6	-0.7
Systolic blood pressure, automated reading	0.5	1.5	5.6	2.4	-0.9	0.3	0.7	1.4	0.8	0.7
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.9	0.7	-1.2	-1.7	-1.0	-0.0	-1.0	-1.1
Angina	0.5	0.7	1.7	1.2	0.2	-1.3	-0.2	-1.2	-0.4	-0.1
Medication for hormone replacement therapy	0.2	0.3	0.7	-0.8	-0.4	0.2	0.6	0.7	0.1	0.4
Vitamin and mineral supplements	0.3	0.5	2.0	1.4	-0.1	-1.0	-0.5	-0.2	0.0	-0.2
Supplements: Zinc	1.6	1.8	4.2	-1.6	2.0	1.3	0.3	1.8	0.5	0.8
Medication: Co-codamol	1.9	2.3	4.2	1.3	-1.6	-0.5	-1.6	-0.7	-2.0	-2.0
Medication: Metformin	0.2	0.3	1.0	0.5	-0.4	-1.0	-0.5	0.4	0.1	-0.8
Diabetes (father)	0.3	0.4	1.7	0.6	-0.5	-0.2	0.1	-0.2	0.4	1.3
Diabetes (mother)	1.0	1.3	3.2	-0.1	1.6	-0.4	-1.2	1.4	-0.1	-1.8
Severe depression (siblings)	1.4	1.6	6.2	0.3	-1.1	-1.1	-0.5	-1.2	0.7	-2.5
Pack years adult smoking proportion	0.9	1.3	3.4	-1.6	0.5	-1.8	1.4	0.2	1.0	0.4
Impedance of leg (right)	0.6	2.8	7.5	-2.7	1.2	-0.2	1.5	1.6	2.3	0.9
Leg fat-free mass (left)	0.3	1.7	3.7	1.6	-1.6	0.3	-1.1	-1.9	-1.3	-0.5
Trunk fat percentage	0.1	0.3	0.6	0.5	-0.8	-0.2	-0.4	-0.5	0.7	-0.3
Hand grip strength (right)	1.8	4.8	8.4	1.7	-1.7	-1.6	-2.4	-2.2	-2.9	-2.5
Townsend deprivation index at recruitment	0.4	0.6	1.9	0.0	1.4	0.3	0.6	0.8	0.8	-0.8
Current tobacco smoking	0.4	0.7	2.1	-1.4	-0.5	0.4	-0.4	-0.4	-0.1	-1.4
Average weekly fortified wine intake	0.1	0.1	0.4	0.1	0.7	-0.3	-0.1	-0.1	-0.2	-0.2
Maternal smoking around birth	1.6	2.3	6.8	-1.4	0.5	2.6	1.9	1.2	1.3	0.5
Fed-up feelings	1.1	2.1	5.2	2.0	-1.6	-1.0	-1.0	-2.3	-1.0	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.5	1.0	-0.7	-1.2	-0.1	-0.4	-0.3	1.0
Relative age voice broke	0.7	1.1	5.8	2.4	-0.7	-0.6	0.3	-0.8	-0.7	0.2
Taking other prescription medications	0.2	0.3	0.5	0.7	0.2	0.6	0.3	0.7	0.5	0.1
Age when periods started (menarche)	0.2	0.5	2.0	-1.4	0.2	0.7	-0.1	-0.4	-0.4	-0.7
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.3	-0.7	-0.2	1.2	0.3	0.9	-0.0	0.1
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	7.5	-1.3	2.0	2.7	0.1	1.1	-1.0	0.3
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.2	-0.5	0.6	-0.3	0.6	0.2	0.3	1.1
Qualifications: CSEs or equivalent	0.6	0.8	3.9	0.2	-2.0	-0.2	-0.1	-1.1	0.1	-0.7
Serious illness, injury or assault to yourself	0.4	0.5	1.7	0.4	-0.4	0.1	-0.7	-0.1	-0.8	-1.3
High blood pressure	0.4	1.2	3.0	1.7	1.3	-1.1	-0.1	1.4	0.3	0.8
Hayfever, allergic rhinitis or eczema	1.6	3.4	5.8	1.7	2.3	0.6	-2.4	1.0	-2.2	-1.9
Multivitamins +/- minerals	0.6	0.8	3.2	-0.9	0.1	1.8	-0.0	0.6	-0.6	-0.8
Stomach or abdominal pain in last month	1.4	1.7	4.1	-1.2	-2.0	-1.2	0.6	-1.3	1.1	1.3
Supplements: Glucosamine	0.6	0.8	2.2	0.1	1.0	1.5	-1.0	0.7	-0.9	-0.3
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.1	-1.1	0.7	0.9	1.5	0.7	1.3	0.6
Medication: Atenolol	0.3	0.3	0.9	0.7	0.8	0.3	-0.3	1.0	-0.5	0.1
Medication: Levothyroxine sodium	0.2	0.4	1.0	1.0	-0.9	-0.0	0.0	-0.4	-0.8	-0.3
Sitting height	0.2	1.6	4.7	-1.2	0.9	0.8	1.5	0.8	2.2	0.8
Chronic bronchitis/emphysema (father)	0.5	0.6	2.6	-0.0	0.2	0.8	-0.5	0.9	-0.2	-1.6
High blood pressure (mother)	0.2	0.2	1.4	-0.3	-0.1	1.2	-0.3	0.4	0.1	0.2
Body mass index (BMI)	0.5	2.1	4.5	2.1	-1.1	0.9	-1.6	-1.5	-1.6	-0.7
Impedance of leg (left)	0.7	3.4	9.6	-3.1	1.1	-0.7	1.6	1.6	2.7	0.5
Leg predicted mass (left)	0.3	1.8	3.8	1.6	-1.6	0.3	-1.1	-1.9	-1.4	-0.6
Trunk fat mass	0.1	0.5	1.5	0.6	-1.2	-0.1	-0.5	-1.2	0.3	-0.3
Waist circumference	0.1	0.3	0.9	0.6	-1.0	0.3	-0.1	-0.7	0.4	0.3
Number of incorrect matches in round	0.6	1.0	2.3	1.5	-1.3	-0.0	-1.1	-0.8	-0.6	-0.9
Past tobacco smoking	0.3	0.5	1.4	-0.7	1.2	0.9	0.4	0.7	0.2	0.4
Alcohol usually taken with meals	0.4	0.6	2.0	-1.4	0.4	-1.0	-0.2	0.3	0.6	0.8
Nervous feelings	0.9	1.7	5.0	2.2	-0.9	-1.4	-0.9	-1.4	-1.0	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.8	1.7	-0.7	-0.5	0.2	-0.6	-0.2	0.4
Hearing difficulty/problems with background noise	1.4	2.2	4.2	-1.2	-2.0	-0.9	-1.4	-1.6	-1.1	-1.8
Hair/balding pattern: Pattern 2	0.3	0.3	1.2	-0.1	0.7	-0.7	-0.2	1.1	-0.4	-0.2
Had menopause	1.0	1.2	5.2	2.3	1.3	0.4	-0.2	1.2	-0.4	0.1
Had other major operations	0.6	0.8	1.4	1.2	0.1	-1.1	-1.2	-0.3	-1.1	-0.3
Forced vital capacity (FVC)	0.2	0.7	1.4	-0.7	-0.8	1.0	-0.7	-0.3	-0.9	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	4.4	-0.8	1.8	2.1	0.2	1.5	-0.7	0.2
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.0	0.3	-0.9	-0.7	-1.0	-0.7	-0.6	-0.9
Qualifications: None of the above	0.2	0.4	1.7	0.7	-0.1	1.3	0.1	-0.0	-0.8	-0.1
Financial difficulties in last 2 years	0.4	0.6	2.4	-0.7	-0.2	0.1	0.7	0.1	0.8	-1.6
Mouth/teeth dental problems	1.0	1.5	5.1	-1.2	2.3	0.6	0.3	1.9	0.4	-0.4
Heart attack	0.7	0.8	2.5	1.2	-0.6	-1.6	0.2	-1.2	0.2	-0.1
Allergy	1.4	3.3	6.9	-1.6	-1.7	-0.1	2.5	-0.4	2.6	2.2
Pain all over the body in last month	0.8	0.8	2.3	0.7	-1.0	-0.8	-0.4	-1.5	-1.1	0.2
Diabetes (self-reported)	0.9	1.3	2.2	1.5	1.3	-0.4	-1.4	1.0	-0.8	-1.3
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.8	0.1	1.1	1.3	-0.2	0.1	-0.1	-0.7
Medication: Ramipril	1.0	1.3	3.1	1.6	-1.8	-1.8	-0.1	-0.7	0.2	-0.4
Medication: Simvastatin	0.4	0.6	3.6	1.9	0.5	0.4	0.3	0.1	0.2	0.1
Fluid intelligence score	0.2	0.3	1.8	0.2	0.2	0.2	-0.4	-0.4	-0.0	-1.3
Illnesses of siblings	0.2	0.3	1.6	-1.3	-0.2	0.2	-0.0	-0.1	0.3	0.7
Neuroticism score	1.2	2.5	5.3	2.3	-1.6	-1.7	-1.5	-1.6	-1.4	-0.8
Weight	0.3	1.4	3.7	1.4	-1.5	0.4	-1.0	-1.9	-0.8	-0.5
Impedance of arm (right)	1.6	7.3	18.1	-3.4	1.1	-0.9	3.0	2.6	4.3	2.0
Arm fat percentage (right)	0.1	0.2	0.5	0.5	-0.7	0.6	-0.2	-0.6	0.1	0.3
Trunk fat-free mass	0.3	1.6	5.5	1.2	-1.5	0.7	-0.4	-2.4	-1.2	0.1
Hip circumference	0.4	1.6	3.4	1.9	-1.1	0.5	-1.2	-1.6	-1.1	-1.1
Time employed in main current job	0.3	0.4	1.5	0.3	-0.4	-1.2	-0.7	-0.1	-0.4	-0.2
Alcohol intake versus 10 years previously	0.8	1.2	5.8	-0.0	-2.4	-0.3	0.1	-1.6	-0.2	0.2
Father’s age at death	0.4	0.5	1.4	-0.9	0.2	0.2	0.7	-0.1	1.2	1.0
Worrier / anxious feelings	2.4	4.5	10.0	3.2	-1.5	-1.4	-2.3	-2.0	-2.3	-1.6
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.3	0.5	-0.2	0.6	0.3	0.2	0.1	-0.4
Falls in the last year	0.3	0.5	1.5	-0.1	-1.2	1.1	0.2	0.3	-0.6	0.3
Hair/balding pattern: Pattern 3	0.5	0.8	1.6	-1.1	-0.7	1.0	0.5	-0.8	-0.6	1.3
Number of live births	0.4	0.6	2.0	1.4	-0.0	-1.3	-0.6	0.0	-0.3	0.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.5	-0.9	-0.4	1.2	0.6	-0.1	-0.3	-0.1
Pulse rate	0.6	1.0	2.2	1.4	-0.8	-1.5	0.3	0.3	1.0	0.8
Happiness	1.6	1.9	3.6	0.7	-1.9	-1.9	-1.5	-1.2	0.2	-1.4
Noisy workplace	0.5	0.7	2.5	-0.8	-0.8	0.3	1.6	-0.4	0.3	0.7
Qualifications: A levels/AS levels or equivalent	0.8	1.8	4.4	-2.1	1.1	-0.1	1.1	1.0	2.1	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.6	-0.1	-0.7	0.4	0.7	0.0	0.8	0.4
Mouth/teeth dental problems: Dentures	0.4	0.7	1.6	0.9	-0.3	1.1	0.9	-0.1	0.4	1.3
Asthma	0.6	1.1	2.6	-0.4	-0.1	-1.0	-1.2	-0.0	-1.5	-1.6
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.4	0.2	-0.5	-0.4	-0.3	-0.3	-0.6	-0.1
Medication: Cholesterol lowering	0.5	0.8	1.6	1.1	-0.4	0.4	1.3	-0.0	1.2	1.1
Depression (self-reported)	0.6	0.7	1.6	-0.7	-1.0	-1.0	-0.2	-1.2	-0.2	-0.6
Medication: Lansoprazole	1.8	2.1	4.3	1.8	0.7	-1.1	-2.1	-0.7	-1.3	-1.7
Prospective memory result	0.7	0.8	2.9	-1.7	-1.3	-0.5	0.2	-0.6	0.3	0.6
Lung cancer (father)	0.3	0.4	2.2	-0.5	0.1	-0.1	0.3	-0.1	0.3	-1.5
Illnesses of mother	0.2	0.3	0.6	-0.4	0.2	-0.3	0.5	-0.2	0.7	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.7	-1.1	-0.6	0.3	1.3	-0.4	0.7	0.2
Pulse wave Arterial Stiffness index	0.6	0.7	1.8	1.3	-0.4	0.8	-1.0	-0.0	-0.7	-0.7
Impedance of arm (left)	1.2	5.6	13.6	-3.0	1.5	-1.5	2.3	2.5	3.7	1.0
Arm fat mass (right)	0.2	0.9	1.9	1.3	-1.2	0.5	-0.9	-1.4	-0.6	-0.3
Trunk predicted mass	0.3	1.7	5.8	1.3	-1.5	0.7	-0.5	-2.4	-1.3	0.0
Standing height	0.1	1.2	3.1	-1.2	-0.8	-1.0	1.1	-1.0	1.8	0.4
Length of working week for main job	3.2	3.5	9.1	0.7	-2.1	-2.2	-1.4	-3.0	-1.5	-1.1
Exposure to tobacco smoke at home	0.5	0.6	1.4	-1.2	0.4	0.3	1.0	1.0	0.6	0.2
Breastfed as a baby	0.7	0.8	2.2	0.5	-1.4	-1.2	0.4	-1.5	0.4	0.1
Tense / ‘highly strung’	1.5	2.4	6.8	0.1	-2.6	-2.6	-0.2	-1.8	-0.4	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	2.8	0.4	-1.3	-1.3	-1.3	-1.2	-1.0	-1.7
Hair/balding pattern: Pattern 4	0.0	0.1	0.3	0.6	-0.4	0.3	0.1	-0.2	0.5	-0.0
Birth weight of first child	0.4	0.8	1.8	0.0	-0.1	-1.3	-1.4	-0.1	-1.1	-0.9
Peak expiratory flow (PEF)	0.4	0.9	4.1	-2.0	0.2	0.8	0.8	0.7	0.6	-0.0
Pulse wave reflection index	2.3	2.9	4.7	1.6	0.7	2.0	-2.2	-0.4	-2.1	-2.0
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.7	-0.5	-0.5	-0.4	0.8	0.5	0.5	0.2
Loud music exposure frequency	0.4	0.5	1.2	-0.6	0.9	0.3	-0.0	-1.1	-0.2	-1.0
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.9	0.4	0.2	-0.6	-1.0	-0.8	-0.9	-1.4
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.0	1.0	0.7	-0.0	-1.0	-0.3	-0.5	-0.9
Blood clot in the leg (DVT)	0.6	0.8	3.6	0.3	-1.9	0.4	0.4	-1.1	-0.0	0.3
Medication: Paracetamol	0.1	0.2	0.5	-0.7	0.4	0.5	0.4	-0.3	0.4	0.3
Headache pain in last month	0.2	0.4	1.4	0.6	0.5	1.2	-0.0	-0.2	-0.7	0.3
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	2.0	-1.4	0.5	0.4	-0.3	0.4	-0.1	-1.0
Glaucoma (self-reported)	0.3	0.4	1.1	0.2	1.0	0.4	0.2	0.7	-0.2	0.8
Gout (self-reported)	0.8	1.1	2.8	-1.2	1.7	1.0	-1.0	0.8	-0.2	-1.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	3.2	1.8	-1.1	0.4	-0.3	-0.1	-0.8	-0.7
Medication: Amlodipine	0.1	0.2	0.4	0.2	-0.5	-0.6	0.4	0.2	0.3	0.6
Medication: Ventolin 100micrograms inhaler	0.7	0.9	3.7	-1.9	-0.1	0.0	0.8	1.1	0.9	0.2
Birth weight	0.2	0.4	2.0	-0.2	0.0	0.4	0.4	-1.4	0.3	-0.8
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.6	0.5	1.2	0.7	0.7	1.3	1.1	0.2
High blood pressure (siblings)	0.3	0.4	1.3	0.4	0.5	-0.1	0.7	1.1	0.8	0.0
Forced vital capacity (FVC), Best measure	0.1	0.4	1.0	-0.9	-1.0	0.1	0.4	-0.6	0.1	-0.7
Body fat percentage	0.1	0.2	0.5	0.3	-0.7	0.2	-0.5	-0.5	0.5	-0.2
Leg fat percentage (right)	0.1	0.4	1.0	0.5	-1.0	0.7	-0.7	-0.9	-0.3	0.1
Arm fat-free mass (right)	0.5	2.5	5.6	1.9	-1.3	0.6	-1.4	-2.4	-1.7	-1.0
Exposure to tobacco smoke outside home	0.3	0.4	1.8	-0.5	0.1	0.3	0.7	0.0	0.5	1.3
Comparative body size at age 10	0.3	0.9	2.2	-1.5	-0.7	-0.6	0.6	0.2	1.2	1.3
Number of full brothers	0.4	0.5	1.4	-1.0	-1.2	0.5	-0.1	-0.1	-0.1	-0.9
Worry too long after embarrassment	0.2	0.4	1.2	0.9	-1.1	-0.2	0.3	-0.6	-0.2	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.4	0.1	-1.2	-1.4	-1.1	-1.2	-0.6	-1.6
Wheeze or whistling in the chest in last year	0.3	0.6	2.4	1.5	0.0	-0.6	-0.8	-0.0	-0.7	-0.5
Number of children fathered	1.9	2.2	7.3	0.3	-0.6	-2.7	-1.3	-1.5	-0.9	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	5.7	0.5	-0.7	-2.4	-0.3	-1.0	-0.0	-0.8
Age at first live birth	0.4	0.7	1.8	-0.5	-0.2	-1.3	-0.9	-0.7	-0.4	-1.3
Pulse wave peak to peak time	0.8	0.9	2.2	-1.5	0.5	-1.0	1.2	0.1	1.0	0.8
Health satisfaction	0.4	0.5	1.5	0.7	-0.9	-1.2	-0.4	-0.1	0.3	-0.5
Shortness of breath walking on level ground	0.4	0.5	1.8	0.2	-1.4	-0.6	-0.0	-1.0	-0.5	0.3
Qualifications: College or University degree	0.5	1.7	3.9	-1.3	0.8	-0.2	1.2	0.7	2.0	1.9
Eye problems/disorders: None of the above	1.5	1.7	5.4	-0.2	-2.3	-1.2	-0.0	-2.3	-0.2	-0.1
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.1	-0.6	0.3	1.0	1.0	0.5	0.4	0.7
Emphysema/chronic bronchitis	0.4	0.4	1.3	-0.3	-0.9	0.2	-0.3	-0.5	-0.6	-1.1
Medication for pain relief, constipation, heartburn	0.2	0.3	1.1	-0.6	0.1	-0.3	-0.4	0.6	-0.4	-1.1
Neck or shoulder pain in last month	0.3	0.5	2.0	0.6	-0.5	1.4	-0.2	-0.2	-0.4	0.8
Medication: Blood pressure	0.4	0.6	2.8	1.7	0.8	0.3	-0.2	0.8	0.2	0.5
Angina (self-reported)	0.5	0.6	1.7	1.2	0.2	-1.3	-0.0	-1.0	-0.1	0.1
Migraine (self-reported)	0.3	0.4	0.9	-0.6	-0.5	-0.7	0.9	0.0	0.7	0.1
Medication: Ibuprofen	0.2	0.2	0.6	-0.7	-0.4	-0.8	0.1	-0.1	-0.5	0.1
Medication: Allopurinol	1.3	1.7	3.1	-0.1	1.7	1.1	-1.7	0.8	-1.1	-1.8
Medication: Omeprazole	0.9	1.1	2.9	-0.3	-1.7	0.0	1.4	-0.5	1.3	0.9
Medication: Seretide 50 evohaler	0.5	0.6	2.3	-0.4	0.1	-0.1	-0.7	-0.1	-1.1	-1.5
Mean time to correctly identify matches	0.2	0.4	0.6	0.5	-0.4	-0.7	-0.3	-0.8	0.6	0.8
Heart disease (mother)	0.6	0.7	1.3	-1.1	0.1	1.1	0.9	0.7	0.9	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	4.6	0.2	0.6	-0.1	-1.9	-0.2	-2.1	-1.6
Whole body fat mass	0.2	0.7	1.7	0.8	-1.2	0.2	-0.7	-1.3	-0.0	-0.2
Leg fat mass (right)	0.3	1.0	2.4	0.9	-1.3	1.0	-1.0	-1.5	-0.6	0.1
Arm predicted mass (right)	0.5	2.5	5.2	1.9	-1.2	0.8	-1.4	-2.3	-1.8	-1.2
Pulse rate, automated reading	0.4	1.3	2.7	1.3	-1.2	-1.6	0.3	-0.5	1.0	1.5
Alcohol intake frequency.	0.3	0.6	0.9	0.5	-0.7	0.9	-0.9	-0.9	-0.6	-0.9
Comparative height size at age 10	0.1	0.6	1.8	-1.1	0.1	0.1	0.5	0.8	1.3	0.2
Number of full sisters	3.3	4.0	13.8	-1.3	0.7	-0.9	2.9	0.8	3.7	1.4
Suffer from ‘nerves’	0.6	1.0	3.4	1.8	-0.0	1.5	-0.1	-0.3	-0.7	0.9
Overall health rating	0.3	0.7	2.2	1.1	-1.5	0.6	-0.7	0.2	0.1	0.7
Chest pain or discomfort	0.6	0.8	1.9	-0.0	1.4	0.8	-0.5	1.3	-0.4	-0.9
Had major operations	0.6	0.7	2.3	-1.0	-0.6	-1.5	-0.0	-0.8	-0.8	0.2
Age at last live birth	0.7	1.0	1.7	-1.3	1.1	-0.9	1.1	1.2	0.9	0.3
Family relationship satisfaction	1.1	1.4	2.9	0.9	-1.0	-1.3	-1.7	-0.7	-0.3	-1.6
Leg pain on walking	0.2	0.2	0.7	0.5	-0.8	0.3	0.1	-0.6	-0.5	-0.3
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	4.7	-0.9	1.1	-0.4	2.1	0.6	2.2	0.4
Commuting to job workplace: Car/motor vehicle	1.2	1.4	4.4	2.1	0.1	-1.4	-1.4	0.6	-0.7	-0.8
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	5.4	-1.5	0.3	-0.0	0.6	-0.6	0.0	2.3
Medication: Aspirin	0.6	0.7	3.6	1.9	-0.0	0.2	-0.2	-0.5	-0.5	1.0
Supplements: Vitamin C	1.4	1.7	5.2	-2.3	0.5	-0.4	1.5	0.1	1.0	1.7
Knee pain experienced in last month	0.3	0.4	1.9	-0.1	-0.0	-0.4	-0.5	-0.3	-1.4	-0.7
Hypertension (Self-reported)	0.5	1.3	3.5	1.9	1.5	-0.8	-0.1	1.6	0.3	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	1.2	0.1	-0.1	-0.3	-1.1	-0.6	0.2	-0.1
Illnesses of father: Heart disease	0.7	1.0	2.0	0.8	-1.1	1.3	-0.6	-1.4	-1.0	0.3
Illnesses of siblings: Diabetes	0.7	0.9	2.9	-0.4	1.3	0.3	0.8	1.7	0.7	0.4
Smoking status: Previous	0.3	0.4	0.8	0.7	-0.9	-0.9	0.3	-0.2	0.8	0.4
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	5.7	-1.8	0.8	-0.1	1.8	1.1	2.4	0.1
Whole body fat-free mass	0.3	1.8	4.9	1.6	-1.5	0.5	-0.8	-2.2	-1.4	-0.4
Leg fat-free mass (right)	0.3	1.7	3.2	1.6	-1.5	0.2	-1.1	-1.8	-1.2	-0.9
Arm fat percentage (left)	0.0	0.2	0.4	0.5	-0.6	0.3	-0.4	-0.6	0.1	-0.1
Average weekly red wine intake	0.7	1.1	4.3	1.0	-0.8	-2.1	-0.5	-1.1	0.4	-0.1
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.4	-0.0	-0.2	0.1	0.1	-0.3	-0.6	0.0
Mood swings	0.0	0.1	0.2	0.2	0.3	-0.0	-0.2	0.5	0.3	-0.1
Loneliness, isolation	1.8	2.5	7.3	1.3	-1.9	-2.2	-0.2	-2.7	-0.4	-0.0
Long-standing illness, disability or infirmity	0.3	0.5	1.1	0.7	-0.5	-1.1	-0.6	-0.4	-0.7	-0.9
Ever had bowel cancer screening	0.4	0.5	1.2	-0.4	-0.3	0.8	0.8	-0.4	1.1	0.8
Diabetes diagnosed by doctor	1.0	1.7	3.6	1.9	0.9	-0.2	-1.7	0.7	-1.3	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.5	0.4	0.1	-0.1	0.2	0.7	0.1	-0.3
Friendships satisfaction	2.1	2.6	5.4	1.5	-1.1	-1.5	-2.3	-1.2	-1.8	-1.5
Qualifications: nursing, teaching	0.2	0.4	1.4	-0.1	0.9	-0.1	0.4	1.2	0.4	0.3
Commuting to job workplace: Walk	0.5	0.5	1.3	-1.1	-0.6	-0.8	0.6	0.1	0.8	-0.0
Eye problems/disorders: Cataract	0.7	0.9	3.4	0.5	1.0	1.0	-0.5	1.8	0.4	-0.3
Mouth/teeth dental problems: Mouth ulcers	1.0	1.7	2.8	1.4	-1.5	-1.2	-1.1	-1.7	-1.2	-0.5
Medication for cholesterol	0.2	0.3	1.4	-1.2	-0.1	-0.3	0.2	-0.1	0.5	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	5.0	0.4	1.2	2.2	0.1	0.2	-0.1	0.1
Back pain experienced in last month	0.5	0.8	1.7	1.3	-0.9	0.3	-0.3	-0.9	-1.0	-0.9
Mineral and other dietary supplements	0.6	0.8	1.3	-1.1	-1.1	0.2	0.8	-0.5	1.1	0.8
Breast cancer (self-reported)	0.3	0.3	1.0	0.7	0.2	-0.8	-1.0	-0.2	-0.1	-0.5
Asthma (self-reported)	0.4	0.8	2.1	-0.4	0.2	-0.7	-0.9	0.6	-1.1	-1.4
Osteoporosis (self-reported)	4.0	4.9	12.5	3.5	-1.0	-1.6	-2.3	-1.4	-2.2	-2.5
Osteoarthritis (self-reported)	0.9	1.2	4.5	0.3	-2.1	-1.1	-0.1	-1.5	-0.4	0.1
Medication: Aspirin	0.9	1.2	5.4	2.3	-0.4	0.1	-1.0	-0.8	-1.0	0.6
Medication: Gliclazide	1.4	1.6	6.7	-0.0	1.2	0.2	0.8	2.6	1.2	0.8
Illnesses of father: None of the above (group 1)	1.9	2.3	7.5	-1.1	-0.1	-1.0	2.7	0.1	2.3	1.2
Smoking status: Current	0.5	0.8	2.7	-1.3	-0.5	0.3	-0.8	-0.5	-0.7	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	3.3	-1.8	-0.3	0.8	1.4	0.4	0.9	0.6
Whole body water mass	0.4	2.0	5.7	1.6	-1.6	0.5	-0.9	-2.4	-1.5	-0.4
Leg predicted mass (right)	0.3	1.7	3.2	1.6	-1.5	0.1	-1.2	-1.8	-1.3	-0.9
Arm fat mass (left)	0.2	0.9	2.1	1.2	-1.1	0.2	-1.0	-1.4	-0.7	-0.5
Number of self-reported non-cancer illnesses	1.3	2.3	6.1	2.5	-0.4	-2.3	-1.0	-0.2	-0.9	-1.6
Average weekly champagne plus white wine intake	0.2	0.2	1.0	-0.2	-1.0	-0.2	-0.6	-0.4	0.2	-0.2
Miserableness	1.3	2.3	4.7	2.1	-0.5	0.9	-2.2	-0.5	-2.0	-1.3
Guilty feelings	1.9	2.8	6.1	1.5	-1.8	-1.0	-1.3	-2.5	-2.2	-0.9
Wears glasses or contact lenses	1.1	1.3	5.7	-0.9	-0.9	-2.4	-0.1	-1.1	0.1	-0.3
Ever taken oral contraceptive pill	0.2	0.3	0.7	0.8	-0.6	-0.5	0.1	-0.4	0.6	-0.0
Hearing aid user	1.1	1.3	3.0	-1.4	-1.7	-1.5	-0.4	-1.2	-0.2	-0.1
Mother’s age at death	0.6	0.8	3.5	0.1	1.9	0.7	-0.2	1.0	0.1	-0.4
Financial situation satisfaction	0.3	0.4	1.7	1.3	-0.1	-0.6	-0.1	0.5	0.4	0.1
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.4	-0.3	1.6	0.3	-0.8	0.3	-0.5	-1.2
Commuting to job workplace: Public transport	2.1	2.5	4.3	-1.3	1.9	1.0	1.8	1.8	2.1	0.9
Eye problems/disorders: Glaucoma	0.2	0.2	0.3	0.5	-0.1	0.5	-0.1	-0.4	-0.6	0.5
Medication: Blood pressure	0.2	0.4	1.2	0.4	0.8	0.6	-0.2	1.1	-0.1	0.7
Pain type(s) experienced in last month: Hip pain	1.1	1.4	3.9	-0.3	-1.5	-2.0	1.0	-1.0	1.1	-0.5
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.8	0.5	0.9	-0.5	0.2	0.2	0.2	-0.2
High cholesterol (Self-reported)	1.0	1.7	5.7	2.4	-1.3	0.5	1.5	-1.1	0.3	1.0
Medication: Bendroflumethiazide	2.2	3.4	6.9	2.6	0.5	-2.0	-2.6	-0.1	-1.9	-1.4
Medication: Paracetamol	0.3	0.4	1.5	-1.2	0.7	-0.2	0.7	-0.1	0.7	0.5
Medication: Lisinopril	0.4	0.5	1.7	0.5	1.3	0.0	-0.6	0.1	-0.4	-1.0
Medication: Atorvastatin	0.2	0.3	0.9	1.0	-0.5	0.3	-0.0	-0.3	-0.6	-0.5
Illnesses of father: High blood pressure	0.7	0.9	3.0	-0.8	1.3	0.6	-0.7	1.7	-0.4	0.2
Alcohol drinker status: Never	0.1	0.1	0.7	-0.9	-0.2	0.2	-0.4	-0.2	0.2	-0.1
Ever smoked	0.2	0.3	0.8	0.1	-0.7	-0.5	-0.3	-0.9	-0.6	-0.6
Basal metabolic rate	0.3	1.7	4.6	1.5	-1.6	0.5	-0.9	-2.1	-1.2	-0.4
Leg fat percentage (left)	0.1	0.4	1.2	0.2	-1.1	0.3	-0.8	-0.9	-0.2	-0.2
Arm fat-free mass (left)	0.4	2.2	4.8	1.9	-1.3	0.9	-1.1	-2.2	-1.7	-0.5
Number of operations (self-reported)	0.6	0.8	2.7	-1.2	0.7	-1.6	-0.1	0.2	-0.4	1.0
Average weekly beer plus cider intake	0.2	0.3	0.7	-0.4	-0.4	-0.3	0.5	0.3	0.8	-0.9
Irritability	0.2	0.4	1.7	0.1	-0.2	-0.7	0.7	0.1	1.3	0.2
Risk taking	0.2	0.3	1.1	-0.5	0.7	0.6	0.4	1.1	-0.1	-0.0
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.5	-1.9	0.4	0.8	1.3	0.9	1.3	1.5
Fractured/broken bones in last 5 years	1.1	1.4	2.9	1.3	0.2	1.7	-0.9	-1.0	-1.7	-0.7
Age started oral contraceptive pill	0.9	1.2	2.4	1.6	-1.5	0.0	-0.6	-1.0	-1.1	0.9
Diastolic blood pressure, automated reading	0.4	1.3	4.9	2.2	-0.6	0.0	0.8	1.2	1.1	0.9
Ever depressed for a whole week	0.1	0.1	0.2	-0.2	-0.4	0.1	-0.2	0.1	0.0	-0.5
Unable to work because of sickness or disability	0.3	0.4	0.9	-0.8	-1.0	-0.2	0.3	0.1	0.3	0.9
Commuting to job workplace: Cycle	0.3	0.4	1.3	-0.9	0.2	-0.1	-0.3	0.1	-0.7	-1.1
Myopia	0.3	0.5	2.0	-0.3	-0.3	-1.4	-0.1	-0.1	0.7	-0.8
Vascular/heart problems diagnosed by doctor	0.5	1.4	4.5	-2.1	-1.3	1.4	0.3	-1.0	-0.3	-0.8
Cholesterol lowering medication	1.5	2.1	7.7	2.8	-0.4	-0.3	-1.2	-1.0	-1.7	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	1.7	-0.2	-1.3	0.1	1.2	-0.7	1.0	0.8
Pain experienced in last month	0.3	0.6	2.3	-0.3	0.6	-0.6	0.8	0.1	1.5	0.2
Supplements: Calcium	0.8	0.9	3.1	0.0	1.8	0.9	0.0	1.4	-0.0	-0.2
Basal cell carcinoma (self-reported)	0.5	0.6	2.9	0.1	-0.3	-1.7	0.2	-1.0	0.1	0.4
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.3	1.1	-0.7	-1.5	0.3	-1.3	0.4	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	3.5	0.3	-1.9	-0.2	0.3	-1.1	-0.0	0.2
Heart disease (siblings)	1.1	1.3	4.0	0.1	-2.0	-1.5	0.8	-1.4	0.2	0.3
Alcohol drinker status: Previous	0.2	0.2	0.8	-0.1	0.9	0.7	-0.1	-0.1	-0.1	-0.5
Pack years of smoking	1.0	1.5	3.4	-1.6	0.1	-1.8	1.7	-0.0	1.1	0.8
Impedance of whole body	1.1	5.4	13.0	-3.2	1.4	-1.2	2.0	2.5	3.6	0.7
Leg fat mass (left)	0.3	1.0	2.5	0.8	-1.4	0.6	-1.0	-1.6	-0.6	-0.0
Arm predicted mass (left)	0.5	2.3	5.5	1.9	-1.5	0.9	-1.1	-2.4	-1.7	-0.5