Hub : Genes

ABCA10

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.2010 0.0400 1.1e-16 0.125 0.173 0.173 0.175 0.168 5.4e-15 1.3e-20 1.5e-20 8.8e-21 5.8e-20
2 GTEx Esophagus Muscularis 0.1200 0.0500 8.8e-03 0.067 NA 0.045 NA 0.033 6.7e-05 NA 1.0e-03 NA 4.1e-03
3 GTEx Heart Atrial Appendage 0.1800 0.0730 5.7e-03 0.020 NA 0.027 NA 0.025 4.2e-02 NA 2.1e-02 NA 2.7e-02
4 GTEx Testis 0.3460 0.0730 9.1e-08 0.227 NA 0.170 NA 0.216 1.9e-10 NA 5.3e-08 NA 5.8e-10
5 METSIM Adipose 0.0570 0.0202 1.5e-04 0.027 0.032 0.020 0.035 0.039 5.9e-05 1.2e-05 4.3e-04 5.5e-06 1.3e-06
6 TCGA Breast Invasive Carcinoma 0.0127 0.0081 3.7e-03 0.023 0.012 0.019 NA 0.021 1.2e-05 1.5e-03 5.8e-05 NA 3.5e-05
7 TCGA Brain Lower Grade Glioma 0.0455 0.0244 1.1e-03 0.019 0.025 0.021 NA 0.017 2.8e-03 7.1e-04 1.9e-03 NA 4.6e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.2 0.3 1.5 -1.2 -0.4 0.1 -0.2 -0.5 0.2 -0.3
Bipolar Disorder or Schizophrenia 0.2 0.4 1.2 -0.6 0.3 -0.9 -0.8 -0.1 -0.1 -1.1
Depressed Affect (Nagel 2018) 0.7 1.4 3.8 1.9 -0.9 -0.7 -1.3 -0.9 -1.4 -0.4
Depression (Nagel 2018) 0.2 0.3 0.6 0.4 -0.4 -0.5 -0.7 -0.2 -0.7 0.4
Intelligence (Savage-Jansen 2018) 1.2 3.6 7.6 1.8 -1.6 -1.1 -2.8 -1.9 -2.0 -1.7
Neuroticism (Nagel 2018) 1.1 2.6 6.2 2.5 -1.7 -1.7 -1.2 -1.6 -1.2 -0.9
Schizophrenia (2018) 0.3 0.6 1.4 0.2 0.7 -1.2 -0.8 0.2 -0.2 -1.2
Schizophrenia vs Biploar Disorder 1.0 1.3 5.3 2.3 0.7 -0.0 -1.0 1.1 -0.9 -0.5
Worry (Nagel 2018) 2.6 5.4 9.4 3.1 -2.3 -2.6 -2.1 -2.1 -1.9 -2.0
Alzheimer’s Disease (in mother) 0.6 0.7 2.1 -0.4 0.4 1.0 -0.7 0.8 -0.5 -1.4
Alzheimer’s Disease (in father) 1.4 1.5 3.5 -0.2 -0.5 -1.9 -1.6 -1.2 -0.7 -1.5
Alzheimer’s Disease (including proxy) 0.3 0.5 1.3 -0.4 -0.1 -0.8 -1.0 -0.1 -0.5 -1.1
Crohns Disease (2017) 0.6 1.2 2.6 0.5 -0.1 -0.8 -1.6 -0.1 -1.6 -1.5
Irritable Bowel Disease (IBD) 1.7 4.0 8.0 1.5 -1.2 -2.2 -2.8 -1.6 -2.3 -2.0
Ulcerative Colitis (UC) 2.4 4.5 6.7 1.6 -1.9 -2.4 -2.6 -2.3 -2.0 -1.8
Major Depression (MDD) 1.3 1.6 3.7 0.5 -1.0 -1.3 -1.7 -0.8 -1.9 -1.1
Reaction Time 0.2 0.4 1.2 1.1 -0.2 -0.2 -0.5 -1.1 -0.3 0.4
Verbal and Numeric Reasoning (VNR) 0.4 1.0 3.0 1.0 0.1 -0.1 -1.7 -0.9 -0.7 -1.3
Breast Cancer 0.4 1.1 2.6 -1.0 -1.6 -1.3 0.8 -1.0 0.7 0.5
Ovarian Cancer 1.1 1.4 2.9 -0.9 1.4 -0.4 1.7 1.1 1.7 0.3
Prostate Cancer 0.3 0.5 1.8 1.3 0.5 0.3 -0.1 -0.6 -0.6 -0.7
Age at First Birth 0.7 1.0 2.9 0.5 -0.1 -0.4 -0.7 -1.7 -1.6 -0.9
Bipolar Disorder (2011) 0.7 0.6 1.4 -0.8 -0.5 -1.2 -0.9 -0.9 -0.4 -0.6
Body Mass Index (BMI) (2010) 0.1 0.2 0.4 -0.4 -0.2 -0.4 -0.6 0.3 -0.5 -0.6
Coronary Artery Disease (CAD) 0.4 0.4 2.7 -0.0 -1.6 0.5 0.2 -0.0 -0.0 0.2
Crohns Disease (2012) 0.7 1.1 2.5 -0.1 -0.6 -1.6 -1.4 -0.6 -1.2 -1.0
Mean Putamen Volume 0.4 0.5 2.6 0.0 0.7 1.6 -0.1 0.3 0.3 0.1
Fasting Glucose 0.9 1.0 3.5 -1.0 1.0 1.9 0.8 0.8 0.4 0.3
HbA1C 0.3 0.3 0.5 -0.6 0.7 0.5 0.3 0.0 0.6 -0.7
HDL Cholesterol 0.9 1.6 4.0 1.5 1.7 2.0 -0.7 0.2 -1.0 -0.5
LDL Cholesterol 0.3 0.5 1.3 1.1 0.4 0.4 0.9 1.0 -0.3 -0.0
Lupus 0.6 0.8 3.0 0.2 0.0 -0.7 1.4 -0.2 1.7 0.7
Neuroticism (2016) 1.6 2.4 5.2 1.9 -1.8 -2.0 0.1 -2.3 -0.3 0.3
Primary Biliary Cirrhosis 3.4 4.8 16.6 0.7 -2.9 -1.4 -1.6 -4.1 -1.5 -1.2
Rheumatoid Arthritis 0.7 1.0 2.7 1.6 -0.2 -1.0 -1.2 -0.5 -0.7 -0.8
Schizophrenia (2014) 0.5 1.2 3.1 -0.1 0.5 -1.1 -1.6 0.2 -1.0 -1.8
Triglycerides 0.5 0.8 2.8 -1.7 -1.0 1.0 0.3 0.5 0.6 0.2
Type 2 Diabetes (T2D) (2012) 0.8 0.9 3.0 -0.4 -0.7 -0.5 1.7 -0.8 1.2 0.6
Ulcerative Colitis 2.5 3.7 5.9 1.7 -2.0 -1.9 -2.4 -2.3 -1.6 -1.1
Blood Eosinophil Count 0.1 0.7 2.4 1.6 -0.5 0.6 -0.8 -0.6 -0.9 0.1
Blood Platelet Count 0.5 5.3 15.4 1.3 0.0 2.0 -3.9 -0.4 -2.6 -3.0
Blood Red Count 0.1 0.7 2.9 1.7 0.8 0.8 0.1 0.8 -0.0 0.5
Blood White Count 1.7 12.3 30.7 2.7 -1.4 0.1 -5.5 -2.6 -4.5 -4.4
Heel T-Score 0.5 3.9 15.1 -1.2 3.9 1.8 1.5 2.2 0.1 -0.4
BMI 0.7 4.0 7.6 2.5 -1.0 0.3 -2.6 -1.3 -2.8 -2.1
Height 0.2 4.3 11.0 -1.7 -1.0 -0.3 3.3 -0.5 3.2 2.3
Waist Hip Ratio (WHR) 1.0 4.6 8.8 -2.9 0.2 -1.5 2.4 1.3 3.0 2.3
Systolic Blood Pressure 0.3 1.5 4.7 2.2 -0.1 -0.3 0.5 2.0 1.3 0.2
Smoking Status 0.4 0.9 2.4 -1.0 -1.4 -0.2 -0.7 -0.8 0.2 -1.6
Allergy or Eczema 1.2 3.2 6.4 1.9 1.5 -0.6 -2.5 0.1 -2.4 -2.0
Cardiovascular Disease 0.5 1.7 9.4 3.1 0.3 -1.3 -0.5 0.0 -0.5 0.7
Hypothyroidism (self reported) 0.2 0.4 1.1 1.1 -0.6 0.6 -0.1 0.1 -0.6 -0.7
Respiratory disease 0.2 0.4 1.7 -0.1 0.3 0.1 -0.5 0.4 -1.3 -0.8
Type 2 Diabetes (T2D) (2018) 0.6 1.1 2.0 1.4 0.3 -0.7 -1.2 0.7 -1.4 -1.0
Lung FEV1/FVC ratio 0.8 4.1 11.8 -1.7 0.9 -0.6 3.4 0.1 2.4 2.7
Lung FVC 0.2 1.1 2.0 0.4 -1.3 -0.0 -1.2 -0.6 -1.3 -1.4
Neuroticism 1.2 3.0 4.6 2.0 -2.0 -1.8 -1.6 -2.1 -1.4 -0.8
Chronotype (morning person) 0.4 1.0 2.2 0.8 -1.2 0.1 -0.7 -1.5 -1.3 -0.6
Hair Pigment 0.0 0.4 1.9 0.7 -1.4 -0.4 0.1 0.0 0.1 0.4
Tanning 0.1 1.3 2.4 -0.6 -1.1 0.4 -1.2 -1.6 -1.4 -1.1
Hand grip strength (left) 0.8 2.0 4.9 0.4 -1.4 -1.6 -0.7 -2.2 -1.8 -1.0
Number of treatments/medications taken 0.2 0.3 1.2 0.3 0.3 -0.7 0.5 0.3 -0.1 1.1
Average weekly spirits intake 1.0 1.3 2.3 1.0 -1.1 -0.1 -1.5 -1.2 -1.2 -1.1
Sensitivity / hurt feelings 0.3 0.6 1.6 1.3 -0.6 0.7 -0.7 -0.1 -0.8 -0.6
Frequency of depressed mood in last 2 weeks 0.7 1.0 2.2 0.7 -1.5 -1.0 -1.2 -1.0 -0.8 -0.2
Hearing difficulty/problems: Yes 0.9 1.4 3.7 -1.9 -1.9 -0.9 0.3 -0.9 0.7 0.4
Relative age of first facial hair 0.5 1.0 4.2 2.1 0.5 -1.0 1.1 0.3 0.1 0.5
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 3.2 0.6 -1.8 -0.9 -0.8 -0.5 -1.3 -0.4
Ever used hormone-replacement therapy (HRT) 0.7 0.8 2.2 -0.6 1.5 1.2 0.2 1.2 -0.4 -0.4
Ever had hysterectomy (womb removed) 0.3 0.4 0.8 -0.7 -0.2 0.4 0.7 0.9 0.6 -0.7
Systolic blood pressure, automated reading 0.5 1.5 5.6 2.4 -0.9 0.3 0.7 1.4 0.8 0.7
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 2.9 0.7 -1.2 -1.7 -1.0 -0.0 -1.0 -1.1
Angina 0.5 0.7 1.7 1.2 0.2 -1.3 -0.2 -1.2 -0.4 -0.1
Medication for hormone replacement therapy 0.2 0.3 0.7 -0.8 -0.4 0.2 0.6 0.7 0.1 0.4
Vitamin and mineral supplements 0.3 0.5 2.0 1.4 -0.1 -1.0 -0.5 -0.2 0.0 -0.2
Supplements: Zinc 1.6 1.8 4.2 -1.6 2.0 1.3 0.3 1.8 0.5 0.8
Medication: Co-codamol 1.9 2.3 4.2 1.3 -1.6 -0.5 -1.6 -0.7 -2.0 -2.0
Medication: Metformin 0.2 0.3 1.0 0.5 -0.4 -1.0 -0.5 0.4 0.1 -0.8
Diabetes (father) 0.3 0.4 1.7 0.6 -0.5 -0.2 0.1 -0.2 0.4 1.3
Diabetes (mother) 1.0 1.3 3.2 -0.1 1.6 -0.4 -1.2 1.4 -0.1 -1.8
Severe depression (siblings) 1.4 1.6 6.2 0.3 -1.1 -1.1 -0.5 -1.2 0.7 -2.5
Pack years adult smoking proportion 0.9 1.3 3.4 -1.6 0.5 -1.8 1.4 0.2 1.0 0.4
Impedance of leg (right) 0.6 2.8 7.5 -2.7 1.2 -0.2 1.5 1.6 2.3 0.9
Leg fat-free mass (left) 0.3 1.7 3.7 1.6 -1.6 0.3 -1.1 -1.9 -1.3 -0.5
Trunk fat percentage 0.1 0.3 0.6 0.5 -0.8 -0.2 -0.4 -0.5 0.7 -0.3
Hand grip strength (right) 1.8 4.8 8.4 1.7 -1.7 -1.6 -2.4 -2.2 -2.9 -2.5
Townsend deprivation index at recruitment 0.4 0.6 1.9 0.0 1.4 0.3 0.6 0.8 0.8 -0.8
Current tobacco smoking 0.4 0.7 2.1 -1.4 -0.5 0.4 -0.4 -0.4 -0.1 -1.4
Average weekly fortified wine intake 0.1 0.1 0.4 0.1 0.7 -0.3 -0.1 -0.1 -0.2 -0.2
Maternal smoking around birth 1.6 2.3 6.8 -1.4 0.5 2.6 1.9 1.2 1.3 0.5
Fed-up feelings 1.1 2.1 5.2 2.0 -1.6 -1.0 -1.0 -2.3 -1.0 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.6 1.5 1.0 -0.7 -1.2 -0.1 -0.4 -0.3 1.0
Relative age voice broke 0.7 1.1 5.8 2.4 -0.7 -0.6 0.3 -0.8 -0.7 0.2
Taking other prescription medications 0.2 0.3 0.5 0.7 0.2 0.6 0.3 0.7 0.5 0.1
Age when periods started (menarche) 0.2 0.5 2.0 -1.4 0.2 0.7 -0.1 -0.4 -0.4 -0.7
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 1.3 -0.7 -0.2 1.2 0.3 0.9 -0.0 0.1
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.2 7.5 -1.3 2.0 2.7 0.1 1.1 -1.0 0.3
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 1.2 -0.5 0.6 -0.3 0.6 0.2 0.3 1.1
Qualifications: CSEs or equivalent 0.6 0.8 3.9 0.2 -2.0 -0.2 -0.1 -1.1 0.1 -0.7
Serious illness, injury or assault to yourself 0.4 0.5 1.7 0.4 -0.4 0.1 -0.7 -0.1 -0.8 -1.3
High blood pressure 0.4 1.2 3.0 1.7 1.3 -1.1 -0.1 1.4 0.3 0.8
Hayfever, allergic rhinitis or eczema 1.6 3.4 5.8 1.7 2.3 0.6 -2.4 1.0 -2.2 -1.9
Multivitamins +/- minerals 0.6 0.8 3.2 -0.9 0.1 1.8 -0.0 0.6 -0.6 -0.8
Stomach or abdominal pain in last month 1.4 1.7 4.1 -1.2 -2.0 -1.2 0.6 -1.3 1.1 1.3
Supplements: Glucosamine 0.6 0.8 2.2 0.1 1.0 1.5 -1.0 0.7 -0.9 -0.3
Diverticular disease/diverticulitis (self-reported) 0.8 1.0 2.1 -1.1 0.7 0.9 1.5 0.7 1.3 0.6
Medication: Atenolol 0.3 0.3 0.9 0.7 0.8 0.3 -0.3 1.0 -0.5 0.1
Medication: Levothyroxine sodium 0.2 0.4 1.0 1.0 -0.9 -0.0 0.0 -0.4 -0.8 -0.3
Sitting height 0.2 1.6 4.7 -1.2 0.9 0.8 1.5 0.8 2.2 0.8
Chronic bronchitis/emphysema (father) 0.5 0.6 2.6 -0.0 0.2 0.8 -0.5 0.9 -0.2 -1.6
High blood pressure (mother) 0.2 0.2 1.4 -0.3 -0.1 1.2 -0.3 0.4 0.1 0.2
Body mass index (BMI) 0.5 2.1 4.5 2.1 -1.1 0.9 -1.6 -1.5 -1.6 -0.7
Impedance of leg (left) 0.7 3.4 9.6 -3.1 1.1 -0.7 1.6 1.6 2.7 0.5
Leg predicted mass (left) 0.3 1.8 3.8 1.6 -1.6 0.3 -1.1 -1.9 -1.4 -0.6
Trunk fat mass 0.1 0.5 1.5 0.6 -1.2 -0.1 -0.5 -1.2 0.3 -0.3
Waist circumference 0.1 0.3 0.9 0.6 -1.0 0.3 -0.1 -0.7 0.4 0.3
Number of incorrect matches in round 0.6 1.0 2.3 1.5 -1.3 -0.0 -1.1 -0.8 -0.6 -0.9
Past tobacco smoking 0.3 0.5 1.4 -0.7 1.2 0.9 0.4 0.7 0.2 0.4
Alcohol usually taken with meals 0.4 0.6 2.0 -1.4 0.4 -1.0 -0.2 0.3 0.6 0.8
Nervous feelings 0.9 1.7 5.0 2.2 -0.9 -1.4 -0.9 -1.4 -1.0 -0.1
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 2.8 1.7 -0.7 -0.5 0.2 -0.6 -0.2 0.4
Hearing difficulty/problems with background noise 1.4 2.2 4.2 -1.2 -2.0 -0.9 -1.4 -1.6 -1.1 -1.8
Hair/balding pattern: Pattern 2 0.3 0.3 1.2 -0.1 0.7 -0.7 -0.2 1.1 -0.4 -0.2
Had menopause 1.0 1.2 5.2 2.3 1.3 0.4 -0.2 1.2 -0.4 0.1
Had other major operations 0.6 0.8 1.4 1.2 0.1 -1.1 -1.2 -0.3 -1.1 -0.3
Forced vital capacity (FVC) 0.2 0.7 1.4 -0.7 -0.8 1.0 -0.7 -0.3 -0.9 -1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.6 4.4 -0.8 1.8 2.1 0.2 1.5 -0.7 0.2
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.0 0.3 -0.9 -0.7 -1.0 -0.7 -0.6 -0.9
Qualifications: None of the above 0.2 0.4 1.7 0.7 -0.1 1.3 0.1 -0.0 -0.8 -0.1
Financial difficulties in last 2 years 0.4 0.6 2.4 -0.7 -0.2 0.1 0.7 0.1 0.8 -1.6
Mouth/teeth dental problems 1.0 1.5 5.1 -1.2 2.3 0.6 0.3 1.9 0.4 -0.4
Heart attack 0.7 0.8 2.5 1.2 -0.6 -1.6 0.2 -1.2 0.2 -0.1
Allergy 1.4 3.3 6.9 -1.6 -1.7 -0.1 2.5 -0.4 2.6 2.2
Pain all over the body in last month 0.8 0.8 2.3 0.7 -1.0 -0.8 -0.4 -1.5 -1.1 0.2
Diabetes (self-reported) 0.9 1.3 2.2 1.5 1.3 -0.4 -1.4 1.0 -0.8 -1.3
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 1.8 0.1 1.1 1.3 -0.2 0.1 -0.1 -0.7
Medication: Ramipril 1.0 1.3 3.1 1.6 -1.8 -1.8 -0.1 -0.7 0.2 -0.4
Medication: Simvastatin 0.4 0.6 3.6 1.9 0.5 0.4 0.3 0.1 0.2 0.1
Fluid intelligence score 0.2 0.3 1.8 0.2 0.2 0.2 -0.4 -0.4 -0.0 -1.3
Illnesses of siblings 0.2 0.3 1.6 -1.3 -0.2 0.2 -0.0 -0.1 0.3 0.7
Neuroticism score 1.2 2.5 5.3 2.3 -1.6 -1.7 -1.5 -1.6 -1.4 -0.8
Weight 0.3 1.4 3.7 1.4 -1.5 0.4 -1.0 -1.9 -0.8 -0.5
Impedance of arm (right) 1.6 7.3 18.1 -3.4 1.1 -0.9 3.0 2.6 4.3 2.0
Arm fat percentage (right) 0.1 0.2 0.5 0.5 -0.7 0.6 -0.2 -0.6 0.1 0.3
Trunk fat-free mass 0.3 1.6 5.5 1.2 -1.5 0.7 -0.4 -2.4 -1.2 0.1
Hip circumference 0.4 1.6 3.4 1.9 -1.1 0.5 -1.2 -1.6 -1.1 -1.1
Time employed in main current job 0.3 0.4 1.5 0.3 -0.4 -1.2 -0.7 -0.1 -0.4 -0.2
Alcohol intake versus 10 years previously 0.8 1.2 5.8 -0.0 -2.4 -0.3 0.1 -1.6 -0.2 0.2
Father’s age at death 0.4 0.5 1.4 -0.9 0.2 0.2 0.7 -0.1 1.2 1.0
Worrier / anxious feelings 2.4 4.5 10.0 3.2 -1.5 -1.4 -2.3 -2.0 -2.3 -1.6
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.3 0.5 -0.2 0.6 0.3 0.2 0.1 -0.4
Falls in the last year 0.3 0.5 1.5 -0.1 -1.2 1.1 0.2 0.3 -0.6 0.3
Hair/balding pattern: Pattern 3 0.5 0.8 1.6 -1.1 -0.7 1.0 0.5 -0.8 -0.6 1.3
Number of live births 0.4 0.6 2.0 1.4 -0.0 -1.3 -0.6 0.0 -0.3 0.1
Forced expiratory volume in 1-second (FEV1) 0.1 0.4 1.5 -0.9 -0.4 1.2 0.6 -0.1 -0.3 -0.1
Pulse rate 0.6 1.0 2.2 1.4 -0.8 -1.5 0.3 0.3 1.0 0.8
Happiness 1.6 1.9 3.6 0.7 -1.9 -1.9 -1.5 -1.2 0.2 -1.4
Noisy workplace 0.5 0.7 2.5 -0.8 -0.8 0.3 1.6 -0.4 0.3 0.7
Qualifications: A levels/AS levels or equivalent 0.8 1.8 4.4 -2.1 1.1 -0.1 1.1 1.0 2.1 0.9
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 0.6 -0.1 -0.7 0.4 0.7 0.0 0.8 0.4
Mouth/teeth dental problems: Dentures 0.4 0.7 1.6 0.9 -0.3 1.1 0.9 -0.1 0.4 1.3
Asthma 0.6 1.1 2.6 -0.4 -0.1 -1.0 -1.2 -0.0 -1.5 -1.6
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.2 0.4 0.2 -0.5 -0.4 -0.3 -0.3 -0.6 -0.1
Medication: Cholesterol lowering 0.5 0.8 1.6 1.1 -0.4 0.4 1.3 -0.0 1.2 1.1
Depression (self-reported) 0.6 0.7 1.6 -0.7 -1.0 -1.0 -0.2 -1.2 -0.2 -0.6
Medication: Lansoprazole 1.8 2.1 4.3 1.8 0.7 -1.1 -2.1 -0.7 -1.3 -1.7
Prospective memory result 0.7 0.8 2.9 -1.7 -1.3 -0.5 0.2 -0.6 0.3 0.6
Lung cancer (father) 0.3 0.4 2.2 -0.5 0.1 -0.1 0.3 -0.1 0.3 -1.5
Illnesses of mother 0.2 0.3 0.6 -0.4 0.2 -0.3 0.5 -0.2 0.7 0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 1.7 -1.1 -0.6 0.3 1.3 -0.4 0.7 0.2
Pulse wave Arterial Stiffness index 0.6 0.7 1.8 1.3 -0.4 0.8 -1.0 -0.0 -0.7 -0.7
Impedance of arm (left) 1.2 5.6 13.6 -3.0 1.5 -1.5 2.3 2.5 3.7 1.0
Arm fat mass (right) 0.2 0.9 1.9 1.3 -1.2 0.5 -0.9 -1.4 -0.6 -0.3
Trunk predicted mass 0.3 1.7 5.8 1.3 -1.5 0.7 -0.5 -2.4 -1.3 0.0
Standing height 0.1 1.2 3.1 -1.2 -0.8 -1.0 1.1 -1.0 1.8 0.4
Length of working week for main job 3.2 3.5 9.1 0.7 -2.1 -2.2 -1.4 -3.0 -1.5 -1.1
Exposure to tobacco smoke at home 0.5 0.6 1.4 -1.2 0.4 0.3 1.0 1.0 0.6 0.2
Breastfed as a baby 0.7 0.8 2.2 0.5 -1.4 -1.2 0.4 -1.5 0.4 0.1
Tense / ‘highly strung’ 1.5 2.4 6.8 0.1 -2.6 -2.6 -0.2 -1.8 -0.4 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 2.8 0.4 -1.3 -1.3 -1.3 -1.2 -1.0 -1.7
Hair/balding pattern: Pattern 4 0.0 0.1 0.3 0.6 -0.4 0.3 0.1 -0.2 0.5 -0.0
Birth weight of first child 0.4 0.8 1.8 0.0 -0.1 -1.3 -1.4 -0.1 -1.1 -0.9
Peak expiratory flow (PEF) 0.4 0.9 4.1 -2.0 0.2 0.8 0.8 0.7 0.6 -0.0
Pulse wave reflection index 2.3 2.9 4.7 1.6 0.7 2.0 -2.2 -0.4 -2.1 -2.0
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.7 -0.5 -0.5 -0.4 0.8 0.5 0.5 0.2
Loud music exposure frequency 0.4 0.5 1.2 -0.6 0.9 0.3 -0.0 -1.1 -0.2 -1.0
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 1.9 0.4 0.2 -0.6 -1.0 -0.8 -0.9 -1.4
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.0 1.0 0.7 -0.0 -1.0 -0.3 -0.5 -0.9
Blood clot in the leg (DVT) 0.6 0.8 3.6 0.3 -1.9 0.4 0.4 -1.1 -0.0 0.3
Medication: Paracetamol 0.1 0.2 0.5 -0.7 0.4 0.5 0.4 -0.3 0.4 0.3
Headache pain in last month 0.2 0.4 1.4 0.6 0.5 1.2 -0.0 -0.2 -0.7 0.3
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 2.0 -1.4 0.5 0.4 -0.3 0.4 -0.1 -1.0
Glaucoma (self-reported) 0.3 0.4 1.1 0.2 1.0 0.4 0.2 0.7 -0.2 0.8
Gout (self-reported) 0.8 1.1 2.8 -1.2 1.7 1.0 -1.0 0.8 -0.2 -1.0
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 3.2 1.8 -1.1 0.4 -0.3 -0.1 -0.8 -0.7
Medication: Amlodipine 0.1 0.2 0.4 0.2 -0.5 -0.6 0.4 0.2 0.3 0.6
Medication: Ventolin 100micrograms inhaler 0.7 0.9 3.7 -1.9 -0.1 0.0 0.8 1.1 0.9 0.2
Birth weight 0.2 0.4 2.0 -0.2 0.0 0.4 0.4 -1.4 0.3 -0.8
Chronic bronchitis/emphysema (mother) 0.7 0.8 1.6 0.5 1.2 0.7 0.7 1.3 1.1 0.2
High blood pressure (siblings) 0.3 0.4 1.3 0.4 0.5 -0.1 0.7 1.1 0.8 0.0
Forced vital capacity (FVC), Best measure 0.1 0.4 1.0 -0.9 -1.0 0.1 0.4 -0.6 0.1 -0.7
Body fat percentage 0.1 0.2 0.5 0.3 -0.7 0.2 -0.5 -0.5 0.5 -0.2
Leg fat percentage (right) 0.1 0.4 1.0 0.5 -1.0 0.7 -0.7 -0.9 -0.3 0.1
Arm fat-free mass (right) 0.5 2.5 5.6 1.9 -1.3 0.6 -1.4 -2.4 -1.7 -1.0
Exposure to tobacco smoke outside home 0.3 0.4 1.8 -0.5 0.1 0.3 0.7 0.0 0.5 1.3
Comparative body size at age 10 0.3 0.9 2.2 -1.5 -0.7 -0.6 0.6 0.2 1.2 1.3
Number of full brothers 0.4 0.5 1.4 -1.0 -1.2 0.5 -0.1 -0.1 -0.1 -0.9
Worry too long after embarrassment 0.2 0.4 1.2 0.9 -1.1 -0.2 0.3 -0.6 -0.2 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 2.4 0.1 -1.2 -1.4 -1.1 -1.2 -0.6 -1.6
Wheeze or whistling in the chest in last year 0.3 0.6 2.4 1.5 0.0 -0.6 -0.8 -0.0 -0.7 -0.5
Number of children fathered 1.9 2.2 7.3 0.3 -0.6 -2.7 -1.3 -1.5 -0.9 -1.6
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 5.7 0.5 -0.7 -2.4 -0.3 -1.0 -0.0 -0.8
Age at first live birth 0.4 0.7 1.8 -0.5 -0.2 -1.3 -0.9 -0.7 -0.4 -1.3
Pulse wave peak to peak time 0.8 0.9 2.2 -1.5 0.5 -1.0 1.2 0.1 1.0 0.8
Health satisfaction 0.4 0.5 1.5 0.7 -0.9 -1.2 -0.4 -0.1 0.3 -0.5
Shortness of breath walking on level ground 0.4 0.5 1.8 0.2 -1.4 -0.6 -0.0 -1.0 -0.5 0.3
Qualifications: College or University degree 0.5 1.7 3.9 -1.3 0.8 -0.2 1.2 0.7 2.0 1.9
Eye problems/disorders: None of the above 1.5 1.7 5.4 -0.2 -2.3 -1.2 -0.0 -2.3 -0.2 -0.1
Mouth/teeth dental problems: Loose teeth 0.4 0.5 1.1 -0.6 0.3 1.0 1.0 0.5 0.4 0.7
Emphysema/chronic bronchitis 0.4 0.4 1.3 -0.3 -0.9 0.2 -0.3 -0.5 -0.6 -1.1
Medication for pain relief, constipation, heartburn 0.2 0.3 1.1 -0.6 0.1 -0.3 -0.4 0.6 -0.4 -1.1
Neck or shoulder pain in last month 0.3 0.5 2.0 0.6 -0.5 1.4 -0.2 -0.2 -0.4 0.8
Medication: Blood pressure 0.4 0.6 2.8 1.7 0.8 0.3 -0.2 0.8 0.2 0.5
Angina (self-reported) 0.5 0.6 1.7 1.2 0.2 -1.3 -0.0 -1.0 -0.1 0.1
Migraine (self-reported) 0.3 0.4 0.9 -0.6 -0.5 -0.7 0.9 0.0 0.7 0.1
Medication: Ibuprofen 0.2 0.2 0.6 -0.7 -0.4 -0.8 0.1 -0.1 -0.5 0.1
Medication: Allopurinol 1.3 1.7 3.1 -0.1 1.7 1.1 -1.7 0.8 -1.1 -1.8
Medication: Omeprazole 0.9 1.1 2.9 -0.3 -1.7 0.0 1.4 -0.5 1.3 0.9
Medication: Seretide 50 evohaler 0.5 0.6 2.3 -0.4 0.1 -0.1 -0.7 -0.1 -1.1 -1.5
Mean time to correctly identify matches 0.2 0.4 0.6 0.5 -0.4 -0.7 -0.3 -0.8 0.6 0.8
Heart disease (mother) 0.6 0.7 1.3 -1.1 0.1 1.1 0.9 0.7 0.9 0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.3 1.6 4.6 0.2 0.6 -0.1 -1.9 -0.2 -2.1 -1.6
Whole body fat mass 0.2 0.7 1.7 0.8 -1.2 0.2 -0.7 -1.3 -0.0 -0.2
Leg fat mass (right) 0.3 1.0 2.4 0.9 -1.3 1.0 -1.0 -1.5 -0.6 0.1
Arm predicted mass (right) 0.5 2.5 5.2 1.9 -1.2 0.8 -1.4 -2.3 -1.8 -1.2
Pulse rate, automated reading 0.4 1.3 2.7 1.3 -1.2 -1.6 0.3 -0.5 1.0 1.5
Alcohol intake frequency. 0.3 0.6 0.9 0.5 -0.7 0.9 -0.9 -0.9 -0.6 -0.9
Comparative height size at age 10 0.1 0.6 1.8 -1.1 0.1 0.1 0.5 0.8 1.3 0.2
Number of full sisters 3.3 4.0 13.8 -1.3 0.7 -0.9 2.9 0.8 3.7 1.4
Suffer from ‘nerves’ 0.6 1.0 3.4 1.8 -0.0 1.5 -0.1 -0.3 -0.7 0.9
Overall health rating 0.3 0.7 2.2 1.1 -1.5 0.6 -0.7 0.2 0.1 0.7
Chest pain or discomfort 0.6 0.8 1.9 -0.0 1.4 0.8 -0.5 1.3 -0.4 -0.9
Had major operations 0.6 0.7 2.3 -1.0 -0.6 -1.5 -0.0 -0.8 -0.8 0.2
Age at last live birth 0.7 1.0 1.7 -1.3 1.1 -0.9 1.1 1.2 0.9 0.3
Family relationship satisfaction 1.1 1.4 2.9 0.9 -1.0 -1.3 -1.7 -0.7 -0.3 -1.6
Leg pain on walking 0.2 0.2 0.7 0.5 -0.8 0.3 0.1 -0.6 -0.5 -0.3
Qualifications: NVQ or HND or HNC or equivalent 1.4 1.7 4.7 -0.9 1.1 -0.4 2.1 0.6 2.2 0.4
Commuting to job workplace: Car/motor vehicle 1.2 1.4 4.4 2.1 0.1 -1.4 -1.4 0.6 -0.7 -0.8
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 5.4 -1.5 0.3 -0.0 0.6 -0.6 0.0 2.3
Medication: Aspirin 0.6 0.7 3.6 1.9 -0.0 0.2 -0.2 -0.5 -0.5 1.0
Supplements: Vitamin C 1.4 1.7 5.2 -2.3 0.5 -0.4 1.5 0.1 1.0 1.7
Knee pain experienced in last month 0.3 0.4 1.9 -0.1 -0.0 -0.4 -0.5 -0.3 -1.4 -0.7
Hypertension (Self-reported) 0.5 1.3 3.5 1.9 1.5 -0.8 -0.1 1.6 0.3 0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 1.2 0.1 -0.1 -0.3 -1.1 -0.6 0.2 -0.1
Illnesses of father: Heart disease 0.7 1.0 2.0 0.8 -1.1 1.3 -0.6 -1.4 -1.0 0.3
Illnesses of siblings: Diabetes 0.7 0.9 2.9 -0.4 1.3 0.3 0.8 1.7 0.7 0.4
Smoking status: Previous 0.3 0.4 0.8 0.7 -0.9 -0.9 0.3 -0.2 0.8 0.4
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.0 5.7 -1.8 0.8 -0.1 1.8 1.1 2.4 0.1
Whole body fat-free mass 0.3 1.8 4.9 1.6 -1.5 0.5 -0.8 -2.2 -1.4 -0.4
Leg fat-free mass (right) 0.3 1.7 3.2 1.6 -1.5 0.2 -1.1 -1.8 -1.2 -0.9
Arm fat percentage (left) 0.0 0.2 0.4 0.5 -0.6 0.3 -0.4 -0.6 0.1 -0.1
Average weekly red wine intake 0.7 1.1 4.3 1.0 -0.8 -2.1 -0.5 -1.1 0.4 -0.1
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.4 -0.0 -0.2 0.1 0.1 -0.3 -0.6 0.0
Mood swings 0.0 0.1 0.2 0.2 0.3 -0.0 -0.2 0.5 0.3 -0.1
Loneliness, isolation 1.8 2.5 7.3 1.3 -1.9 -2.2 -0.2 -2.7 -0.4 -0.0
Long-standing illness, disability or infirmity 0.3 0.5 1.1 0.7 -0.5 -1.1 -0.6 -0.4 -0.7 -0.9
Ever had bowel cancer screening 0.4 0.5 1.2 -0.4 -0.3 0.8 0.8 -0.4 1.1 0.8
Diabetes diagnosed by doctor 1.0 1.7 3.6 1.9 0.9 -0.2 -1.7 0.7 -1.3 -1.4
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.5 0.4 0.1 -0.1 0.2 0.7 0.1 -0.3
Friendships satisfaction 2.1 2.6 5.4 1.5 -1.1 -1.5 -2.3 -1.2 -1.8 -1.5
Qualifications: nursing, teaching 0.2 0.4 1.4 -0.1 0.9 -0.1 0.4 1.2 0.4 0.3
Commuting to job workplace: Walk 0.5 0.5 1.3 -1.1 -0.6 -0.8 0.6 0.1 0.8 -0.0
Eye problems/disorders: Cataract 0.7 0.9 3.4 0.5 1.0 1.0 -0.5 1.8 0.4 -0.3
Mouth/teeth dental problems: Mouth ulcers 1.0 1.7 2.8 1.4 -1.5 -1.2 -1.1 -1.7 -1.2 -0.5
Medication for cholesterol 0.2 0.3 1.4 -1.2 -0.1 -0.3 0.2 -0.1 0.5 0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 0.9 5.0 0.4 1.2 2.2 0.1 0.2 -0.1 0.1
Back pain experienced in last month 0.5 0.8 1.7 1.3 -0.9 0.3 -0.3 -0.9 -1.0 -0.9
Mineral and other dietary supplements 0.6 0.8 1.3 -1.1 -1.1 0.2 0.8 -0.5 1.1 0.8
Breast cancer (self-reported) 0.3 0.3 1.0 0.7 0.2 -0.8 -1.0 -0.2 -0.1 -0.5
Asthma (self-reported) 0.4 0.8 2.1 -0.4 0.2 -0.7 -0.9 0.6 -1.1 -1.4
Osteoporosis (self-reported) 4.0 4.9 12.5 3.5 -1.0 -1.6 -2.3 -1.4 -2.2 -2.5
Osteoarthritis (self-reported) 0.9 1.2 4.5 0.3 -2.1 -1.1 -0.1 -1.5 -0.4 0.1
Medication: Aspirin 0.9 1.2 5.4 2.3 -0.4 0.1 -1.0 -0.8 -1.0 0.6
Medication: Gliclazide 1.4 1.6 6.7 -0.0 1.2 0.2 0.8 2.6 1.2 0.8
Illnesses of father: None of the above (group 1) 1.9 2.3 7.5 -1.1 -0.1 -1.0 2.7 0.1 2.3 1.2
Smoking status: Current 0.5 0.8 2.7 -1.3 -0.5 0.3 -0.8 -0.5 -0.7 -1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 3.3 -1.8 -0.3 0.8 1.4 0.4 0.9 0.6
Whole body water mass 0.4 2.0 5.7 1.6 -1.6 0.5 -0.9 -2.4 -1.5 -0.4
Leg predicted mass (right) 0.3 1.7 3.2 1.6 -1.5 0.1 -1.2 -1.8 -1.3 -0.9
Arm fat mass (left) 0.2 0.9 2.1 1.2 -1.1 0.2 -1.0 -1.4 -0.7 -0.5
Number of self-reported non-cancer illnesses 1.3 2.3 6.1 2.5 -0.4 -2.3 -1.0 -0.2 -0.9 -1.6
Average weekly champagne plus white wine intake 0.2 0.2 1.0 -0.2 -1.0 -0.2 -0.6 -0.4 0.2 -0.2
Miserableness 1.3 2.3 4.7 2.1 -0.5 0.9 -2.2 -0.5 -2.0 -1.3
Guilty feelings 1.9 2.8 6.1 1.5 -1.8 -1.0 -1.3 -2.5 -2.2 -0.9
Wears glasses or contact lenses 1.1 1.3 5.7 -0.9 -0.9 -2.4 -0.1 -1.1 0.1 -0.3
Ever taken oral contraceptive pill 0.2 0.3 0.7 0.8 -0.6 -0.5 0.1 -0.4 0.6 -0.0
Hearing aid user 1.1 1.3 3.0 -1.4 -1.7 -1.5 -0.4 -1.2 -0.2 -0.1
Mother’s age at death 0.6 0.8 3.5 0.1 1.9 0.7 -0.2 1.0 0.1 -0.4
Financial situation satisfaction 0.3 0.4 1.7 1.3 -0.1 -0.6 -0.1 0.5 0.4 0.1
Tinnitus: Yes, now most or all of the time 0.6 0.7 2.4 -0.3 1.6 0.3 -0.8 0.3 -0.5 -1.2
Commuting to job workplace: Public transport 2.1 2.5 4.3 -1.3 1.9 1.0 1.8 1.8 2.1 0.9
Eye problems/disorders: Glaucoma 0.2 0.2 0.3 0.5 -0.1 0.5 -0.1 -0.4 -0.6 0.5
Medication: Blood pressure 0.2 0.4 1.2 0.4 0.8 0.6 -0.2 1.1 -0.1 0.7
Pain type(s) experienced in last month: Hip pain 1.1 1.4 3.9 -0.3 -1.5 -2.0 1.0 -1.0 1.1 -0.5
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.8 0.5 0.9 -0.5 0.2 0.2 0.2 -0.2
High cholesterol (Self-reported) 1.0 1.7 5.7 2.4 -1.3 0.5 1.5 -1.1 0.3 1.0
Medication: Bendroflumethiazide 2.2 3.4 6.9 2.6 0.5 -2.0 -2.6 -0.1 -1.9 -1.4
Medication: Paracetamol 0.3 0.4 1.5 -1.2 0.7 -0.2 0.7 -0.1 0.7 0.5
Medication: Lisinopril 0.4 0.5 1.7 0.5 1.3 0.0 -0.6 0.1 -0.4 -1.0
Medication: Atorvastatin 0.2 0.3 0.9 1.0 -0.5 0.3 -0.0 -0.3 -0.6 -0.5
Illnesses of father: High blood pressure 0.7 0.9 3.0 -0.8 1.3 0.6 -0.7 1.7 -0.4 0.2
Alcohol drinker status: Never 0.1 0.1 0.7 -0.9 -0.2 0.2 -0.4 -0.2 0.2 -0.1
Ever smoked 0.2 0.3 0.8 0.1 -0.7 -0.5 -0.3 -0.9 -0.6 -0.6
Basal metabolic rate 0.3 1.7 4.6 1.5 -1.6 0.5 -0.9 -2.1 -1.2 -0.4
Leg fat percentage (left) 0.1 0.4 1.2 0.2 -1.1 0.3 -0.8 -0.9 -0.2 -0.2
Arm fat-free mass (left) 0.4 2.2 4.8 1.9 -1.3 0.9 -1.1 -2.2 -1.7 -0.5
Number of operations (self-reported) 0.6 0.8 2.7 -1.2 0.7 -1.6 -0.1 0.2 -0.4 1.0
Average weekly beer plus cider intake 0.2 0.3 0.7 -0.4 -0.4 -0.3 0.5 0.3 0.8 -0.9
Irritability 0.2 0.4 1.7 0.1 -0.2 -0.7 0.7 0.1 1.3 0.2
Risk taking 0.2 0.3 1.1 -0.5 0.7 0.6 0.4 1.1 -0.1 -0.0
Ever had prostate specific antigen (PSA) test 1.3 1.5 3.5 -1.9 0.4 0.8 1.3 0.9 1.3 1.5
Fractured/broken bones in last 5 years 1.1 1.4 2.9 1.3 0.2 1.7 -0.9 -1.0 -1.7 -0.7
Age started oral contraceptive pill 0.9 1.2 2.4 1.6 -1.5 0.0 -0.6 -1.0 -1.1 0.9
Diastolic blood pressure, automated reading 0.4 1.3 4.9 2.2 -0.6 0.0 0.8 1.2 1.1 0.9
Ever depressed for a whole week 0.1 0.1 0.2 -0.2 -0.4 0.1 -0.2 0.1 0.0 -0.5
Unable to work because of sickness or disability 0.3 0.4 0.9 -0.8 -1.0 -0.2 0.3 0.1 0.3 0.9
Commuting to job workplace: Cycle 0.3 0.4 1.3 -0.9 0.2 -0.1 -0.3 0.1 -0.7 -1.1
Myopia 0.3 0.5 2.0 -0.3 -0.3 -1.4 -0.1 -0.1 0.7 -0.8
Vascular/heart problems diagnosed by doctor 0.5 1.4 4.5 -2.1 -1.3 1.4 0.3 -1.0 -0.3 -0.8
Cholesterol lowering medication 1.5 2.1 7.7 2.8 -0.4 -0.3 -1.2 -1.0 -1.7 -1.3
Medication: Omeprazole (e.g. Zanprol) 0.6 0.8 1.7 -0.2 -1.3 0.1 1.2 -0.7 1.0 0.8
Pain experienced in last month 0.3 0.6 2.3 -0.3 0.6 -0.6 0.8 0.1 1.5 0.2
Supplements: Calcium 0.8 0.9 3.1 0.0 1.8 0.9 0.0 1.4 -0.0 -0.2
Basal cell carcinoma (self-reported) 0.5 0.6 2.9 0.1 -0.3 -1.7 0.2 -1.0 0.1 0.4
Heart attack/myocardial infarction (self-reported) 0.6 0.8 2.3 1.1 -0.7 -1.5 0.3 -1.3 0.4 -0.1
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 3.5 0.3 -1.9 -0.2 0.3 -1.1 -0.0 0.2
Heart disease (siblings) 1.1 1.3 4.0 0.1 -2.0 -1.5 0.8 -1.4 0.2 0.3
Alcohol drinker status: Previous 0.2 0.2 0.8 -0.1 0.9 0.7 -0.1 -0.1 -0.1 -0.5
Pack years of smoking 1.0 1.5 3.4 -1.6 0.1 -1.8 1.7 -0.0 1.1 0.8
Impedance of whole body 1.1 5.4 13.0 -3.2 1.4 -1.2 2.0 2.5 3.6 0.7
Leg fat mass (left) 0.3 1.0 2.5 0.8 -1.4 0.6 -1.0 -1.6 -0.6 -0.0
Arm predicted mass (left) 0.5 2.3 5.5 1.9 -1.5 0.9 -1.1 -2.4 -1.7 -0.5