Hub : Genes

ABCC4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0950	0.0340	2.2e-03	0.000	0.016	0.024	0.021	0.005	3.5e-01	3.9e-03	5.3e-04	1.2e-03	8.0e-02
2	GTEx	Adipose Visceral Omentum	0.1650	0.0560	3.0e-03	0.029	NA	0.009	NA	0.038	1.2e-02	NA	1.0e-01	NA	4.4e-03
3	GTEx	Artery Aorta	0.1480	0.0570	5.9e-03	0.011	NA	-0.001	NA	0.008	7.9e-02	NA	3.9e-01	NA	1.1e-01
4	GTEx	Cells Transformed fibroblasts	0.2490	0.0540	4.7e-06	0.123	NA	0.080	NA	0.095	1.7e-09	NA	1.4e-06	NA	1.3e-07
5	GTEx	Esophagus Gastroesophageal Junction	0.3940	0.0940	4.7e-05	-0.008	NA	0.116	NA	0.058	8.4e-01	NA	5.5e-05	NA	3.9e-03
6	GTEx	Esophagus Muscularis	0.3490	0.0720	7.3e-07	0.061	NA	0.310	NA	0.321	1.4e-04	NA	2.7e-19	NA	4.5e-20
7	GTEx	Heart Atrial Appendage	0.5150	0.0770	2.5e-07	0.265	NA	0.262	NA	0.275	2.7e-12	NA	3.7e-12	NA	9.1e-13
8	GTEx	Testis	0.3170	0.0800	8.2e-05	-0.006	NA	0.000	NA	-0.004	7.0e-01	NA	3.3e-01	NA	5.7e-01
9	GTEx	Thyroid	0.2870	0.0530	3.0e-09	0.058	NA	0.159	NA	0.136	3.0e-05	NA	3.1e-12	NA	1.5e-10
10	METSIM	Adipose	0.0390	0.0183	1.0e-02	0.001	0.005	0.001	0.005	0.010	2.4e-01	4.7e-02	1.8e-01	5.0e-02	1.1e-02
11	NTR	Blood	0.0466	0.0135	3.5e-06	0.005	0.026	0.015	0.025	0.013	7.0e-03	5.5e-09	1.2e-05	9.9e-09	4.3e-05
12	TCGA	Prostate Adenocarcinoma	0.1573	0.0421	4.0e-07	0.074	0.064	0.042	NA	0.049	3.7e-08	2.6e-07	3.0e-05	NA	6.7e-06
13	TCGA	Thyroid Carcinoma	0.0840	0.0300	3.5e-04	0.012	0.038	0.008	NA	0.016	2.3e-02	1.3e-04	4.6e-02	NA	9.9e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	1.2	1.9	5.2	1.1	-1.4	1.7	-1.0	1.2	2.3	-0.9	-0.8	1.8	0.4	0.9	-2.2	0.7
Bipolar Disorder or Schizophrenia	0.5	1.2	3.1	0.1	-1.3	1.0	-1.1	1.8	1.7	-1.1	0.2	1.4	-0.4	-0.2	-1.3	0.9
Depressed Affect (Nagel 2018)	0.4	0.9	4.8	-0.0	-0.7	2.2	0.2	0.3	-0.3	-1.4	-0.8	0.7	0.5	1.3	-0.4	0.8
Depression (Nagel 2018)	0.8	1.3	7.9	2.8	0.4	1.6	0.6	1.5	0.3	0.3	0.0	1.0	0.9	-0.3	0.8	0.5
Intelligence (Savage-Jansen 2018)	0.3	0.8	2.3	0.5	1.1	-1.5	0.2	0.1	0.3	0.6	-0.4	-1.1	1.4	-1.3	0.8	-0.4
Neuroticism (Nagel 2018)	0.5	1.1	3.7	0.8	-0.8	1.9	0.6	1.1	-0.4	-1.3	0.1	1.4	0.9	0.4	0.1	1.6
Schizophrenia (2018)	0.2	0.5	1.9	-0.8	-0.6	-0.0	-0.6	1.4	0.3	-0.7	0.8	0.3	-0.8	-0.9	0.1	0.5
Schizophrenia vs Biploar Disorder	0.1	0.2	0.7	-0.5	-0.1	0.1	0.3	-0.0	-0.8	0.1	0.1	-0.7	-0.2	-0.3	-0.4	-0.4
Worry (Nagel 2018)	0.3	0.6	1.9	0.7	0.4	1.1	0.6	0.9	-0.8	0.2	0.0	1.4	1.0	0.0	0.0	1.0
Alzheimer’s Disease (in mother)	1.5	1.7	6.2	-1.9	2.2	0.3	0.2	-1.8	-2.5	1.8	-0.4	-0.4	0.2	-0.5	0.0	-0.7
Alzheimer’s Disease (in father)	0.6	0.7	3.9	-0.2	-1.0	-2.0	-0.8	0.2	0.1	-0.4	0.9	-0.1	-0.2	-0.4	-1.4	-0.2
Alzheimer’s Disease (including proxy)	0.6	0.9	3.3	-1.7	1.5	0.2	0.2	-0.8	-1.8	1.4	-0.4	-0.1	0.3	-0.5	-0.2	-0.7
Crohns Disease (2017)	0.2	0.5	1.1	0.4	-0.4	0.7	-0.6	-0.9	-1.0	-0.0	0.2	-1.0	0.7	0.5	0.9	-0.9
Irritable Bowel Disease (IBD)	0.3	0.7	4.2	-0.0	-0.5	1.2	-0.5	-0.5	-0.9	-0.5	-0.4	-0.7	0.2	0.5	2.0	-0.2
Ulcerative Colitis (UC)	0.3	0.6	3.9	-0.2	-0.3	0.7	-0.3	-0.5	-1.0	-0.5	-0.6	-0.0	-0.6	0.4	2.0	0.8
Major Depression (MDD)	1.0	1.2	5.5	0.4	-0.7	-0.1	0.5	1.3	0.8	-0.4	-0.3	-0.6	-0.9	-2.3	0.5	2.3
Reaction Time	0.8	1.5	3.5	1.2	-1.9	0.0	-1.0	0.9	0.6	-0.9	0.9	1.0	-1.8	-0.9	1.7	1.8
Verbal and Numeric Reasoning (VNR)	0.5	1.3	4.1	0.7	1.4	-2.0	1.3	-0.9	-0.4	1.0	-0.2	-1.4	0.9	-1.6	0.4	-1.0
Breast Cancer	0.5	1.1	5.9	-0.2	1.0	-0.1	0.0	0.6	-0.5	0.8	-1.0	-1.5	1.6	0.7	-0.3	-2.4
Ovarian Cancer	0.7	0.9	2.4	-0.8	0.1	-0.5	-0.5	-1.3	-1.3	0.4	0.8	1.4	-1.6	-0.6	0.3	1.2
Prostate Cancer	0.5	0.7	2.9	1.7	-1.4	0.3	-0.3	1.0	0.5	-0.8	-0.1	-0.8	-0.1	0.2	-1.2	-0.4
Age at First Birth	0.8	1.1	6.0	-1.0	0.4	-1.1	-0.7	-0.9	0.5	0.1	-0.1	-1.8	-0.5	0.2	-1.1	-2.5
Bipolar Disorder (2011)	2.1	2.1	7.7	1.0	-1.0	-1.5	-2.2	0.7	1.6	-1.3	-1.4	-0.1	0.5	1.0	-2.8	-1.4
Body Mass Index (BMI) (2010)	1.4	2.0	6.6	-0.4	0.1	0.5	-0.7	0.4	-0.6	-1.7	1.5	2.2	-2.6	-2.1	-0.1	1.7
Coronary Artery Disease (CAD)	0.9	1.0	4.8	-1.0	-0.4	2.2	-0.0	-0.3	-1.2	1.1	-0.1	0.4	-0.5	1.8	0.7	0.6
Crohns Disease (2012)	0.4	0.6	1.9	1.2	0.3	1.1	-0.3	0.7	0.0	0.4	-1.3	0.2	0.5	0.0	1.4	-0.6
Mean Putamen Volume	0.6	0.6	2.2	-0.6	0.7	-0.0	1.3	-0.6	-0.3	0.3	1.3	-0.7	0.2	-1.5	-0.6	0.7
Fasting Glucose	0.8	0.9	3.5	0.3	0.6	-0.5	-0.9	0.7	1.0	0.2	0.5	-1.9	1.4	1.0	-0.4	-1.4
HbA1C	0.6	0.7	3.1	-0.1	0.3	-1.2	-0.2	0.7	0.4	1.8	0.2	-1.6	1.1	-0.0	-0.5	0.0
HDL Cholesterol	0.5	0.8	2.7	-0.2	0.1	-0.2	-0.6	-1.2	-1.4	1.6	-1.0	-0.5	-0.6	1.0	-0.6	-1.0
LDL Cholesterol	0.8	1.3	3.2	-1.2	0.4	-0.6	1.2	1.5	0.9	-1.0	1.7	1.2	-0.0	-1.3	-0.1	1.8
Lupus	0.6	1.0	4.9	-1.1	0.2	-0.9	0.4	1.1	0.0	0.3	0.9	0.9	-0.8	-1.2	0.5	2.2
Neuroticism (2016)	0.4	0.5	1.6	0.3	0.8	1.1	1.2	-0.5	-1.2	0.2	-0.4	-0.2	1.0	-0.2	0.6	0.7
Primary Biliary Cirrhosis	0.7	1.0	6.1	2.5	-1.2	0.8	-0.1	1.5	0.8	-0.9	0.5	0.6	0.2	-0.2	0.0	0.7
Rheumatoid Arthritis	1.2	1.6	4.4	0.4	1.5	1.8	-0.1	-1.2	-1.5	1.2	-0.4	-0.6	1.2	2.1	1.5	-1.4
Schizophrenia (2014)	0.2	0.4	2.7	-0.2	-0.1	1.6	-0.4	1.1	0.1	-0.4	0.6	0.4	-0.6	-0.0	-0.4	-0.0
Triglycerides	0.8	1.2	6.0	-0.8	0.9	0.2	1.7	0.3	0.1	-0.7	2.5	1.3	0.2	-0.8	0.6	1.5
Type 2 Diabetes (T2D) (2012)	0.5	0.6	3.3	-0.1	0.3	1.8	-0.4	-0.2	0.6	0.5	0.3	-0.2	0.5	1.5	0.9	-0.3
Ulcerative Colitis	0.8	1.1	7.2	-0.4	-0.6	2.7	-0.8	1.3	0.6	0.0	-0.5	0.8	-0.6	0.8	1.4	0.3
Blood Eosinophil Count	0.1	0.8	3.5	0.1	1.9	0.7	0.4	0.3	0.1	1.2	-0.1	-0.4	0.4	1.8	1.1	-0.7
Blood Platelet Count	1.8	21.2	61.5	-1.6	5.2	3.9	7.8	-1.0	1.1	4.2	2.0	6.5	-7.8	0.9	0.3	6.3
Blood Red Count	0.4	4.2	10.2	-1.9	2.0	1.4	2.8	1.2	0.9	2.6	2.0	1.4	-1.9	-3.2	2.3	1.8
Blood White Count	0.1	0.6	2.5	-1.6	0.3	0.9	-0.1	-0.8	-1.1	0.8	-0.5	0.8	-0.7	0.1	0.6	0.1
Heel T-Score	0.0	0.4	1.9	-1.4	0.3	-0.3	-0.0	-0.4	-0.0	-1.0	0.1	-0.5	0.2	0.9	-0.3	-0.7
BMI	0.3	1.9	13.2	0.2	1.7	3.6	0.6	-1.2	-0.1	-0.1	-0.6	-1.1	1.9	-0.6	1.1	-0.6
Height	0.1	1.8	6.4	1.1	-0.1	-0.6	-2.5	-1.1	0.8	0.6	-0.6	-1.1	0.9	1.9	-2.2	-1.5
Waist Hip Ratio (WHR)	0.1	0.7	2.6	0.3	-0.1	-0.4	-0.8	0.1	0.6	-0.9	-1.2	-1.0	1.6	0.0	-0.1	-1.3
Systolic Blood Pressure	0.4	2.2	7.7	-1.2	2.0	0.3	2.8	1.9	0.6	1.6	0.1	0.7	-0.3	-1.5	2.4	0.8
Smoking Status	0.2	0.4	2.9	-0.4	-0.2	0.5	0.5	0.8	-0.6	-0.4	-0.2	0.2	0.1	-0.1	0.3	1.7
Allergy or Eczema	0.5	1.4	5.1	1.0	1.1	-1.7	-0.5	-2.2	-2.0	0.7	0.7	0.1	-0.5	-0.0	-1.0	-1.3
Cardiovascular Disease	0.4	1.4	3.5	1.3	1.6	1.5	0.2	1.4	-0.4	0.0	-0.3	-1.5	1.9	-1.1	1.5	-0.6
Hypothyroidism (self reported)	0.6	1.3	4.1	0.3	-1.2	0.7	0.2	-2.0	-0.5	-1.2	-0.0	0.9	-1.8	0.1	-0.9	1.9
Respiratory disease	0.4	0.8	5.2	2.3	-0.5	-0.3	-0.4	-1.6	-1.5	0.3	0.0	-0.2	0.3	0.1	-0.6	-0.2
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.6	1.0	0.0	-0.4	-1.5	1.5	1.6	0.5	-1.3	-0.8	0.2	-1.6	1.0	-0.1
Lung FEV1/FVC ratio	0.1	0.7	3.0	-0.5	0.6	0.2	1.3	1.2	-0.2	0.2	-0.5	1.3	-0.8	-0.3	1.7	0.1
Lung FVC	0.2	1.0	6.9	-0.3	-0.9	-0.4	0.2	-1.2	-0.6	-1.4	0.3	-0.2	-0.1	-1.0	-2.6	0.4
Neuroticism	0.5	1.1	5.0	0.2	-0.5	2.2	0.8	0.7	-0.8	-1.0	-0.8	1.5	0.8	0.2	0.2	1.5
Chronotype (morning person)	0.6	1.5	3.5	0.8	1.3	1.9	1.2	1.3	0.8	1.4	-1.6	1.1	1.0	0.5	1.4	-0.6
Hair Pigment	0.0	0.4	1.5	0.1	-0.3	-0.1	0.5	-1.1	-0.1	1.1	-0.6	-0.0	-0.8	0.2	1.2	-0.7
Tanning	0.0	0.5	1.3	-0.4	1.1	1.2	0.7	1.0	0.2	-0.8	-0.8	0.3	1.0	-0.2	-0.0	0.3
Hand grip strength (left)	0.3	0.7	3.3	-0.9	0.2	0.4	0.1	-1.8	-1.3	-0.5	-0.5	-0.7	1.0	0.7	-0.7	-0.5
Number of treatments/medications taken	1.0	1.7	7.3	-0.6	0.0	1.8	0.6	2.7	0.5	-0.9	1.1	0.6	-0.8	-1.8	0.9	2.0
Average weekly spirits intake	0.4	0.5	1.8	-1.4	-0.0	-0.6	-0.3	0.1	0.2	-1.3	-1.0	-0.3	0.4	0.6	0.0	0.2
Sensitivity / hurt feelings	0.6	1.0	4.6	-0.6	0.8	2.1	0.4	1.4	0.8	-0.2	0.5	0.6	0.5	-0.5	1.6	0.6
Frequency of depressed mood in last 2 weeks	0.4	0.6	3.5	1.9	0.1	1.6	0.3	0.5	-0.8	0.6	-0.2	-0.2	0.3	-0.4	-0.2	0.0
Hearing difficulty/problems: Yes	0.8	1.2	5.7	1.6	-2.4	-0.7	-1.3	0.9	0.3	-1.8	0.4	-0.3	0.9	0.3	-0.4	-0.4
Relative age of first facial hair	0.1	0.2	1.2	-0.2	-0.0	-0.3	0.3	-0.1	0.4	-0.2	0.6	1.1	-0.5	-0.6	-0.4	0.4
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	3.7	1.9	-0.9	-1.0	-1.6	-0.3	1.2	-0.5	-0.5	-0.8	1.9	1.1	-0.2	-0.3
Ever used hormone-replacement therapy (HRT)	0.9	1.2	3.6	1.0	1.2	0.3	1.9	0.5	-0.5	0.5	1.3	1.5	-1.1	-0.8	0.9	1.5
Ever had hysterectomy (womb removed)	1.9	2.1	6.7	-0.6	1.8	1.7	2.1	0.5	0.5	0.7	2.1	2.6	-0.2	-0.6	0.9	1.9
Systolic blood pressure, automated reading	0.6	1.7	7.1	-1.5	1.5	1.0	1.8	0.5	-0.6	1.7	0.1	1.3	-0.3	-0.6	2.7	0.7
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	3.7	-0.3	0.4	0.8	0.3	1.4	1.2	-0.3	0.3	0.7	0.8	-1.9	-0.6	1.0
Angina	0.9	1.1	4.0	1.3	0.6	1.8	-0.2	0.4	0.7	0.3	-1.1	-2.0	1.4	0.6	0.8	-1.0
Medication for hormone replacement therapy	0.8	0.9	3.4	0.2	1.2	1.0	1.8	-0.1	-0.9	-0.2	-0.4	1.2	-0.1	1.2	1.4	0.8
Vitamin and mineral supplements	1.1	1.5	5.3	-0.4	1.7	-0.4	0.0	-0.8	-0.3	1.6	-1.3	-2.3	1.1	1.4	1.4	-1.0
Supplements: Zinc	0.2	0.2	0.8	-0.0	-0.0	0.2	0.0	-0.9	-0.9	-0.1	-0.3	-0.2	0.3	0.3	-0.6	-0.2
Medication: Co-codamol	0.5	0.6	4.0	0.1	-1.3	0.5	-0.7	0.6	-0.8	-2.0	-0.2	-0.0	-0.5	-0.0	0.1	0.1
Medication: Metformin	0.6	0.9	2.4	0.8	0.5	0.6	-1.5	1.2	1.0	0.4	0.1	0.8	-0.5	-1.5	1.1	0.7
Diabetes (father)	0.8	1.0	4.1	0.2	-1.5	0.1	-2.0	-1.5	-0.7	-0.8	-1.2	-0.1	0.2	0.0	-0.1	-1.2
Diabetes (mother)	0.5	0.7	1.6	-0.9	1.2	1.1	0.9	-1.1	-0.5	0.4	0.4	-1.0	0.8	-0.5	0.5	-0.7
Severe depression (siblings)	1.2	1.4	8.2	1.1	-1.1	-1.1	-0.6	-1.6	-2.9	-0.6	-0.4	-1.0	-0.2	-0.3	-0.8	0.4
Pack years adult smoking proportion	0.9	1.4	5.1	-2.0	-0.3	0.9	0.7	-2.2	-1.6	0.1	-0.4	-0.1	-1.6	-1.1	-0.7	0.6
Impedance of leg (right)	0.2	0.7	3.7	-0.3	-0.3	-1.9	0.5	0.3	-0.7	0.9	1.4	0.8	-1.1	0.7	0.2	0.2
Leg fat-free mass (left)	0.3	1.8	5.4	0.6	1.0	2.3	-1.9	-0.4	1.1	0.3	-1.7	-1.3	1.7	0.7	-1.1	-1.6
Trunk fat percentage	0.2	1.0	3.6	-0.3	1.0	1.7	-0.7	-0.8	-0.5	-1.0	0.1	-1.1	1.9	0.1	0.6	-0.9
Hand grip strength (right)	0.3	0.9	3.6	-1.9	-0.0	0.3	0.1	-1.9	-1.9	-0.3	0.3	-0.4	0.6	0.1	-0.6	0.0
Townsend deprivation index at recruitment	0.8	1.2	2.8	1.0	-0.2	-0.4	-1.3	1.3	1.5	0.0	0.7	-1.7	1.6	1.4	0.2	-0.5
Current tobacco smoking	0.3	0.5	1.7	0.9	-0.0	-0.4	-0.4	-0.1	-0.8	0.1	-0.9	-1.3	0.5	-0.8	0.3	1.0
Average weekly fortified wine intake	1.7	2.0	6.4	-0.3	0.8	0.8	2.5	0.3	0.2	0.8	2.0	0.8	-0.9	-2.2	1.9	1.8
Maternal smoking around birth	1.0	1.4	5.7	0.6	0.3	0.8	-1.0	-1.5	-2.0	0.1	-0.6	-0.4	1.5	2.4	-0.3	-1.2
Fed-up feelings	0.4	0.8	3.1	0.1	-0.4	1.8	-0.9	0.7	0.7	-0.5	-1.2	-0.6	0.9	1.3	-0.9	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	5.5	2.3	1.0	1.7	0.6	1.7	0.9	0.6	-0.5	0.4	1.1	0.2	0.2	-0.4
Relative age voice broke	0.5	0.7	4.2	-0.4	-0.1	-1.0	-0.8	-0.6	0.5	-2.1	0.3	-0.9	0.8	-0.8	0.7	0.3
Taking other prescription medications	0.6	0.9	3.8	0.6	-1.8	-0.9	-0.6	-0.0	0.1	-1.3	0.0	-0.9	-0.4	0.1	0.0	2.0
Age when periods started (menarche)	0.4	1.0	3.4	-0.7	-0.9	1.5	-1.8	1.2	1.0	-0.7	-0.7	0.7	-0.3	0.2	1.1	0.6
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.5	1.0	-0.0	0.5	-1.0	-0.0	-0.4	-1.2	1.1	0.4	-0.1	0.9	0.6	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	4.4	0.2	1.5	1.2	0.6	1.4	1.3	1.8	-0.2	0.1	-0.5	-0.6	2.1	0.8
Tinnitus: Yes, but not now, but have in the past	1.9	2.0	6.6	-0.1	-0.2	-2.6	-2.3	-0.6	-0.1	-1.2	-1.6	-1.8	1.5	1.7	-0.4	-1.0
Qualifications: CSEs or equivalent	1.0	1.4	4.1	-2.0	-0.7	0.8	-1.9	0.5	1.1	-1.4	-0.7	-1.0	-1.5	0.3	-0.4	-1.1
Serious illness, injury or assault to yourself	0.8	0.9	2.7	-0.1	-1.5	-0.1	-1.6	-0.8	0.4	-1.6	-1.5	-0.6	0.2	0.8	0.7	-0.3
High blood pressure	0.3	1.0	2.9	1.4	1.4	1.0	-0.1	0.4	0.4	0.8	-0.7	-0.3	1.7	-1.0	1.6	-0.1
Hayfever, allergic rhinitis or eczema	0.5	1.1	3.3	0.0	1.3	-1.2	-0.3	-1.8	-1.6	0.8	0.7	0.3	-1.0	-0.2	-1.2	-1.3
Multivitamins +/- minerals	1.0	1.3	5.9	0.0	-0.6	1.0	0.7	0.4	0.6	-0.5	2.1	2.4	-1.3	-1.0	0.1	1.3
Stomach or abdominal pain in last month	1.2	1.4	5.3	0.8	0.4	1.4	-0.2	2.3	2.0	-0.1	-0.5	0.4	0.7	1.2	1.9	0.7
Supplements: Glucosamine	0.8	1.0	3.6	0.4	-0.2	-0.9	1.6	0.3	-0.9	0.8	-0.2	1.9	-0.4	-1.4	-1.6	-0.0
Diverticular disease/diverticulitis (self-reported)	1.8	2.1	8.2	1.1	2.9	0.4	-0.3	1.2	1.1	1.7	-0.2	-1.4	2.3	1.2	0.6	-1.8
Medication: Atenolol	0.8	1.0	5.3	0.2	1.2	0.8	0.8	0.8	-0.3	0.3	-2.3	-0.9	0.3	1.1	1.1	0.4
Medication: Levothyroxine sodium	0.3	0.6	2.9	0.3	0.5	0.7	1.7	-0.7	0.4	0.0	-0.1	-1.2	-0.1	1.2	0.4	0.1
Sitting height	0.1	1.0	3.5	0.9	0.5	0.5	-1.7	-0.5	0.4	1.3	-0.9	-0.2	0.5	0.8	-1.9	-1.4
Chronic bronchitis/emphysema (father)	0.8	1.0	6.6	0.8	-0.2	2.6	-0.1	-0.3	-0.1	1.6	1.1	-0.3	0.5	0.5	-0.8	-0.0
High blood pressure (mother)	0.3	0.4	1.8	0.7	0.1	-0.5	-0.9	0.0	1.3	-0.4	-0.7	-0.5	0.7	-0.3	-0.1	0.2
Body mass index (BMI)	0.4	1.7	8.7	-0.4	1.4	2.9	-0.4	-0.6	0.4	-0.5	-1.5	-1.5	2.2	0.1	0.9	-0.9
Impedance of leg (left)	0.1	0.7	3.6	-0.6	-0.6	-1.9	0.3	-0.5	-1.7	0.3	0.6	0.6	-0.9	0.6	0.3	0.3
Leg predicted mass (left)	0.4	2.0	5.7	0.7	1.0	2.4	-2.0	-0.5	1.1	0.3	-1.7	-1.3	1.8	0.8	-1.3	-1.7
Trunk fat mass	0.3	1.3	5.1	-0.1	1.1	2.3	-1.1	-0.9	-0.1	-0.7	-0.7	-1.1	2.0	0.5	0.2	-1.3
Waist circumference	0.6	2.1	8.8	-0.2	1.1	2.5	-1.3	-0.5	0.6	-0.4	-1.6	-1.5	3.0	0.7	1.0	-1.5
Number of incorrect matches in round	0.4	0.6	3.0	-1.7	0.4	0.1	-0.3	0.9	0.5	-0.7	-0.4	-1.3	0.4	0.9	-0.7	-0.2
Past tobacco smoking	0.4	0.7	1.9	-0.7	0.8	1.3	0.4	-0.5	-0.0	1.4	-1.2	0.7	-0.9	-1.0	0.9	-0.1
Alcohol usually taken with meals	1.1	1.8	4.3	-2.1	-0.9	-0.2	1.7	-0.9	-1.8	-1.5	0.4	2.0	-1.1	-0.9	-1.5	0.1
Nervous feelings	0.8	1.6	4.3	1.3	1.5	1.5	1.8	2.1	0.6	1.5	0.9	1.0	0.6	-0.9	0.0	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	2.0	-1.3	0.2	1.4	-0.8	-0.1	-0.5	-0.4	-0.9	-0.8	1.3	0.6	-0.9	-0.8
Hearing difficulty/problems with background noise	1.2	1.9	8.9	0.7	-3.0	-0.2	-1.5	1.6	1.4	-2.0	-0.3	-0.9	1.0	1.1	-1.1	0.7
Hair/balding pattern: Pattern 2	2.4	3.1	10.6	0.1	-0.7	0.1	-1.3	-0.9	-0.3	-0.4	-2.0	-2.2	3.3	1.8	-2.0	-3.2
Had menopause	1.4	1.7	5.7	-0.4	1.7	1.0	2.4	0.0	-0.3	1.8	1.8	0.9	0.2	-0.5	2.0	0.7
Had other major operations	0.2	0.3	1.1	0.4	0.3	-0.1	0.1	-1.0	-0.2	0.7	-0.7	0.8	0.5	-0.2	-0.4	0.8
Forced vital capacity (FVC)	0.4	1.6	10.3	-0.2	-0.7	-0.2	-1.1	-0.9	-0.7	-1.3	-1.4	-0.3	0.4	0.5	-3.2	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	3.2	0.2	1.6	0.9	-0.9	0.4	-0.2	1.0	-0.6	-0.8	0.5	0.2	1.8	-1.4
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.8	-0.6	0.2	0.5	0.4	0.5	0.4	0.5	-0.1	0.4	0.5	-0.2	-0.9	0.8
Qualifications: None of the above	0.3	0.7	2.7	0.4	-0.4	0.0	0.7	-0.4	-0.5	0.4	0.9	1.4	-0.3	-1.3	-0.2	1.6
Financial difficulties in last 2 years	0.9	1.3	4.0	1.2	-0.7	1.2	-1.2	0.7	1.7	1.5	-2.0	-0.5	0.1	1.2	0.6	-0.4
Mouth/teeth dental problems	0.5	0.8	2.9	0.0	1.3	-0.9	1.7	-0.9	-1.5	0.5	0.4	0.8	-0.2	0.0	0.7	0.2
Heart attack	0.8	1.0	4.4	-0.5	2.1	-0.5	0.5	-0.0	0.7	0.9	-0.0	-2.0	0.8	-0.7	1.3	-0.2
Allergy	0.3	0.6	1.6	-1.1	-0.8	-0.0	-0.0	1.3	1.2	-0.8	-0.4	-0.6	0.6	-0.4	0.4	0.7
Pain all over the body in last month	0.7	0.8	1.7	1.1	-1.0	-0.5	-0.5	-0.5	-1.1	-1.3	-0.8	-0.6	0.8	-0.3	-1.2	-0.8
Diabetes (self-reported)	0.9	1.3	4.1	1.2	0.8	1.8	-0.7	2.0	1.4	0.9	-0.7	-1.0	1.1	-0.7	1.2	-0.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	3.2	1.3	-0.2	-1.1	-0.2	1.8	-0.0	-0.5	0.6	-0.7	0.3	-1.0	-0.1	-0.4
Medication: Ramipril	1.4	1.7	7.7	-1.7	1.3	1.3	-1.4	0.3	1.0	0.1	-1.1	-1.6	2.8	0.6	0.4	-1.0
Medication: Simvastatin	0.4	0.6	2.2	-0.3	1.3	0.6	-0.7	0.6	-0.4	-0.4	-0.3	-1.2	0.7	-0.9	1.5	0.0
Fluid intelligence score	0.4	0.8	4.2	1.1	0.3	-2.1	1.3	-1.0	-0.5	-0.3	-0.7	-0.8	0.0	-0.9	0.2	0.0
Illnesses of siblings	0.7	0.9	2.5	-1.0	-1.0	-0.6	-1.6	-0.9	-0.9	-1.5	-0.6	0.4	0.6	1.1	-0.2	-1.2
Neuroticism score	0.4	0.8	6.2	0.5	-0.2	2.5	0.8	0.8	-0.0	-0.1	-0.3	1.0	0.6	-0.1	0.3	1.2
Weight	0.4	2.0	6.1	0.2	1.1	2.5	-1.6	-1.2	0.3	-0.2	-1.8	-1.4	2.3	0.8	-0.4	-1.7
Impedance of arm (right)	0.3	1.3	7.9	0.4	-0.3	-2.4	0.0	0.9	-0.5	-0.3	2.8	0.8	-1.0	-0.2	-0.2	0.0
Arm fat percentage (right)	0.3	1.0	4.4	-0.6	0.9	2.1	-0.3	-0.4	-0.0	-1.1	-0.3	-0.9	1.9	0.1	1.1	-0.7
Trunk fat-free mass	0.3	1.9	4.3	0.5	0.3	1.6	-2.1	-1.1	1.2	0.2	-2.1	-0.9	1.5	1.4	-1.7	-1.5
Hip circumference	0.4	1.7	6.2	0.4	1.7	2.4	-0.5	-0.3	0.7	0.1	-1.4	-1.6	2.5	0.7	0.3	-1.4
Time employed in main current job	0.5	0.5	1.4	0.8	-0.8	-0.1	-0.2	1.2	1.1	-0.6	0.6	0.9	-0.5	-0.4	-0.6	0.9
Alcohol intake versus 10 years previously	0.2	0.2	0.6	0.2	-0.4	0.7	0.1	-0.8	0.1	0.8	-0.5	-0.8	0.1	0.6	-0.1	0.2
Father’s age at death	1.3	1.8	4.4	-2.1	-1.9	-0.7	-0.5	-0.1	0.1	-1.1	0.8	2.1	-2.0	-0.3	-0.6	1.8
Worrier / anxious feelings	0.2	0.4	1.0	1.0	-0.6	-0.1	0.2	0.8	0.1	1.0	-1.0	0.2	-0.0	0.3	0.8	0.8
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	4.6	1.3	-1.2	1.6	-1.8	0.8	1.0	-1.1	-1.9	-2.1	1.3	1.9	0.0	-0.8
Falls in the last year	0.7	1.0	4.7	1.2	-2.2	0.4	-0.3	-0.8	0.2	-0.7	0.8	-0.5	-0.9	-0.6	0.6	1.5
Hair/balding pattern: Pattern 3	0.7	1.0	5.3	-0.5	0.1	0.6	-0.5	1.6	1.5	-0.6	0.2	1.2	-2.3	0.2	0.4	0.3
Number of live births	0.7	1.0	6.0	-0.4	0.5	1.3	-0.2	1.1	0.7	1.2	-0.2	0.4	0.3	0.8	2.4	0.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	4.6	-0.8	-0.4	-0.4	-0.9	-0.7	-1.0	-1.5	-1.9	-0.3	0.3	0.7	-2.1	-2.0
Pulse rate	0.4	0.7	2.7	-1.1	-0.7	-1.0	-0.1	-1.5	-0.4	-0.3	0.4	0.8	0.7	0.5	-1.6	0.6
Happiness	0.5	0.6	2.3	1.1	-0.4	0.2	-0.8	0.4	0.6	-1.5	1.2	-1.1	0.3	0.7	0.4	0.6
Noisy workplace	0.6	0.7	3.8	-0.2	-0.5	0.9	-0.6	0.9	-1.0	-1.0	0.8	0.4	2.0	-0.1	-0.2	0.8
Qualifications: A levels/AS levels or equivalent	0.6	1.3	4.0	2.0	-1.1	-0.4	-1.9	-0.7	0.2	-0.7	-1.4	-0.4	1.3	0.4	-1.2	-0.9
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	4.0	1.2	-1.2	-1.4	-2.0	-0.9	-0.7	-1.7	-1.0	-0.5	-0.2	-0.6	-0.7	-1.1
Mouth/teeth dental problems: Dentures	0.7	1.2	3.5	0.4	-0.8	0.2	-1.0	1.9	1.5	-1.5	-0.1	0.2	1.1	-1.1	-0.9	1.6
Asthma	0.2	0.4	1.9	0.7	0.2	0.6	0.3	-1.4	-0.9	0.3	0.2	-0.2	0.3	1.0	0.0	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.1	-0.5	0.6	0.2	1.1	0.4	-0.9	0.5	0.8	-0.5	-0.8	0.1	0.4	1.0
Medication: Cholesterol lowering	0.5	0.7	2.5	-0.2	0.1	0.5	-1.4	0.3	-1.2	-1.5	-0.5	-1.6	0.7	-0.3	-0.1	-0.3
Depression (self-reported)	0.2	0.3	1.1	-0.1	-0.3	-0.5	0.3	-0.4	-0.6	-0.5	-0.2	-1.1	0.8	-0.1	0.2	0.9
Medication: Lansoprazole	0.9	1.0	4.0	-0.2	-0.7	-1.4	-0.7	0.3	2.0	-1.9	-0.2	-0.6	-0.9	0.9	0.5	-0.8
Prospective memory result	0.7	0.9	3.7	0.8	-1.1	-0.4	-1.5	-1.3	-1.9	-0.5	-1.0	-0.2	-0.5	0.8	-0.1	-0.1
Lung cancer (father)	1.0	1.2	3.6	1.7	-0.6	-1.2	-0.1	-1.9	-0.2	0.3	-0.2	-1.6	0.9	1.1	-1.3	-1.1
Illnesses of mother	0.9	1.1	4.8	-0.5	-1.6	-0.0	-0.1	0.6	-0.5	-0.6	1.6	2.2	-1.7	0.3	-0.4	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	4.0	-0.9	-0.9	0.2	-0.3	0.0	-0.4	-1.9	-1.2	-0.3	-0.2	0.7	-2.0	-1.3
Pulse wave Arterial Stiffness index	0.9	1.1	3.4	0.3	-1.7	-1.2	-1.5	-1.0	-0.1	-0.8	0.3	-0.7	0.3	1.0	-1.8	-0.4
Impedance of arm (left)	0.4	1.7	9.3	0.7	-0.6	-3.0	-0.1	-0.0	-1.0	-0.1	2.7	1.2	-1.4	-0.4	-0.7	0.2
Arm fat mass (right)	0.3	1.4	5.7	-0.4	1.1	2.4	-1.2	-0.8	0.0	-0.6	-1.0	-1.1	2.1	0.7	0.3	-1.3
Trunk predicted mass	0.3	1.9	4.8	0.5	0.3	1.7	-2.0	-1.1	1.1	0.3	-2.2	-1.0	1.6	1.5	-1.6	-1.5
Standing height	0.2	2.3	10.4	1.0	-0.6	-0.7	-2.7	-1.7	-0.1	0.4	-0.9	-0.2	0.6	1.6	-3.2	-2.0
Length of working week for main job	0.5	0.6	2.8	0.1	0.3	1.7	1.0	-0.2	-0.7	0.8	-0.6	-0.1	-0.7	0.2	-1.1	-0.9
Exposure to tobacco smoke at home	0.6	0.7	2.0	0.2	1.2	-0.3	-0.2	0.5	0.8	0.6	-0.1	-1.4	0.8	1.1	0.8	-1.2
Breastfed as a baby	1.5	1.9	6.3	-0.9	-0.1	2.5	1.1	0.9	1.3	-0.9	0.9	2.2	-1.9	-0.8	-0.1	1.5
Tense / ‘highly strung’	0.4	0.7	4.0	0.8	0.2	2.0	0.5	0.9	-0.8	-0.2	0.5	1.0	-0.5	-0.4	0.6	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	2.8	0.3	-0.3	0.3	-0.5	-1.4	-1.7	-0.3	-0.8	-0.8	0.0	0.5	-1.0	0.3
Hair/balding pattern: Pattern 4	0.5	1.2	5.8	1.0	1.4	-0.9	0.5	0.3	-1.1	0.8	-0.4	-1.2	1.5	0.1	2.4	0.2
Birth weight of first child	0.5	1.0	3.8	-1.3	-1.2	-0.4	-1.0	-1.1	-0.5	-0.2	0.6	1.0	-0.7	-0.1	-1.9	-1.0
Peak expiratory flow (PEF)	0.9	2.1	7.2	-0.4	1.4	0.2	-0.5	0.2	-0.8	-0.7	-2.7	-1.1	1.8	2.7	0.1	-2.2
Pulse wave reflection index	0.3	0.3	1.8	1.3	0.4	0.2	-0.3	0.5	-0.0	0.5	0.3	0.3	-0.3	1.0	-0.1	-0.6
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.8	1.2	-0.2	1.2	-1.1	0.2	-1.0	-1.3	-0.3	0.0	0.9	0.1	-0.3	-0.3
Loud music exposure frequency	2.2	2.4	7.4	0.6	2.4	1.6	-1.0	0.7	0.0	1.8	-1.9	-1.3	1.1	2.7	0.2	-2.0
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.9	0.2	1.1	0.5	-1.0	0.1	0.4	-0.6	-1.5	-1.2	1.5	1.0	0.3	-2.0
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	3.1	-0.0	-0.5	0.3	-1.6	-1.8	-0.3	0.4	0.9	-1.0	-0.2	0.1	-1.3	-1.7
Blood clot in the leg (DVT)	0.8	1.0	5.4	0.4	-0.6	2.3	-1.1	0.6	0.3	-1.8	-0.8	1.0	-0.5	-0.2	-0.5	-0.4
Medication: Paracetamol	0.5	0.9	5.3	-1.4	0.1	0.5	-0.5	2.3	0.3	-0.3	-0.3	0.6	-0.0	0.2	1.4	1.0
Headache pain in last month	0.4	0.8	3.7	-1.9	-0.1	1.0	0.1	0.6	1.3	0.1	0.6	0.7	0.2	1.2	0.1	0.8
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	5.1	-0.4	-0.6	-2.3	0.0	-1.5	0.5	1.0	1.1	1.5	-1.0	0.8	-1.2	0.4
Glaucoma (self-reported)	1.3	1.5	3.1	1.2	1.2	-1.8	0.4	1.4	1.6	1.2	1.5	0.8	-1.6	-1.1	-0.2	0.7
Gout (self-reported)	0.5	0.7	2.7	-0.5	-1.1	1.6	-0.5	-0.2	-0.5	-0.8	-0.8	0.6	-1.3	-0.6	-0.7	0.2
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	3.2	0.6	-1.2	0.5	0.2	-1.8	-0.5	-1.5	-0.5	-0.4	-1.4	0.6	-1.0	1.0
Medication: Amlodipine	1.0	1.3	6.6	-0.2	0.5	0.8	0.9	0.5	1.3	0.2	1.0	2.3	-0.2	-2.6	-0.1	0.9
Medication: Ventolin 100micrograms inhaler	0.8	1.0	6.3	-0.7	-1.1	-0.1	-0.7	-0.5	0.3	-0.3	2.5	1.2	-1.4	-0.5	-0.7	0.4
Birth weight	0.5	1.2	4.1	-0.1	-1.6	-0.5	-2.0	-0.3	0.9	-1.8	-0.7	0.3	0.7	1.4	-1.0	-0.2
Chronic bronchitis/emphysema (mother)	0.9	1.0	3.8	-0.3	1.4	-0.0	-0.6	-1.1	-0.9	0.0	-0.1	-0.4	1.9	1.3	0.9	-1.5
High blood pressure (siblings)	0.8	1.2	3.6	1.5	0.4	-0.2	1.6	0.7	1.7	1.9	0.8	0.8	-0.6	-0.8	0.8	1.0
Forced vital capacity (FVC), Best measure	0.3	1.0	7.9	-0.2	-0.9	-0.0	-0.5	-0.7	-0.3	-1.2	-0.6	0.1	-0.4	0.4	-2.8	-1.1
Body fat percentage	0.2	1.0	3.7	-0.4	0.9	1.9	-0.6	-0.8	-0.5	-0.8	-0.2	-1.0	1.9	0.2	0.9	-0.7
Leg fat percentage (right)	0.4	1.3	7.1	-0.4	1.3	2.7	0.4	-0.6	-0.5	0.0	-0.7	-0.9	1.8	0.4	1.5	-0.5
Arm fat-free mass (right)	0.4	1.9	5.3	0.4	0.7	2.1	-1.9	-1.3	0.8	0.4	-2.3	-1.3	1.6	1.0	-1.0	-1.3
Exposure to tobacco smoke outside home	0.7	1.0	4.6	1.0	1.1	1.5	1.3	0.2	1.0	0.3	-2.1	-0.1	-0.3	-0.5	0.1	0.9
Comparative body size at age 10	1.1	3.1	12.3	0.3	-1.6	-1.9	-3.5	-2.4	0.5	-1.1	-2.4	-1.9	1.0	1.4	-0.9	-1.2
Number of full brothers	1.1	1.4	3.5	-0.7	-0.3	1.9	1.8	1.6	0.5	0.1	1.3	-1.0	-1.2	-1.4	0.5	1.3
Worry too long after embarrassment	1.4	2.3	7.4	1.4	-1.2	1.2	1.2	2.0	1.2	-0.4	1.7	1.7	-1.0	-1.9	0.7	2.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.6	0.6	-1.2	-0.5	-1.0	-0.6	1.0	-0.2	0.8	-0.7	0.4	-0.2	-1.2	1.0
Wheeze or whistling in the chest in last year	0.2	0.4	1.2	0.3	0.7	0.2	1.1	0.5	0.9	0.6	0.1	-1.1	0.9	-0.4	0.3	0.4
Number of children fathered	0.4	0.5	2.1	0.8	-0.6	0.1	0.1	0.6	-0.8	-0.3	-0.7	1.5	0.1	1.0	0.6	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	4.0	-0.4	-0.3	0.5	-1.7	-0.0	0.4	-0.8	0.7	-1.0	0.6	0.8	-1.6	-2.0
Age at first live birth	0.9	1.5	5.0	-1.8	-1.4	0.0	-0.5	-2.1	-1.3	-1.6	0.0	0.6	-0.6	0.3	-2.2	-0.4
Pulse wave peak to peak time	0.7	0.9	2.9	-0.4	1.7	1.0	1.2	1.0	0.3	0.9	-0.2	0.5	-0.4	-0.9	1.7	0.1
Health satisfaction	0.5	0.7	3.6	0.3	-0.7	0.8	0.4	-1.2	-0.4	0.1	0.7	0.2	-0.8	-0.8	0.4	1.9
Shortness of breath walking on level ground	0.5	0.6	1.9	0.3	-0.1	-1.4	-0.1	0.5	1.4	0.7	0.6	0.3	-0.1	-1.0	-0.7	0.9
Qualifications: College or University degree	0.5	1.7	5.6	0.8	-1.0	-2.4	0.6	-0.9	-1.0	-1.3	1.5	1.2	-1.2	-1.1	-1.6	1.5
Eye problems/disorders: None of the above	0.7	0.8	3.5	-1.5	0.9	1.1	0.1	0.1	-0.4	1.0	-0.2	-0.7	-0.0	1.0	1.9	-0.6
Mouth/teeth dental problems: Loose teeth	0.9	1.1	3.4	-1.1	1.8	1.4	1.8	0.2	-0.7	0.8	-0.1	0.5	0.4	0.0	1.6	-0.1
Emphysema/chronic bronchitis	0.2	0.2	0.7	0.6	-0.8	0.1	0.3	0.4	-0.2	-0.7	-0.1	-0.1	-0.1	0.2	0.5	0.8
Medication for pain relief, constipation, heartburn	0.7	1.1	7.3	0.8	-0.3	-1.8	-0.3	-2.7	-0.3	1.2	-0.2	-0.4	-0.5	-0.3	0.8	-0.9
Neck or shoulder pain in last month	0.9	1.2	8.4	-0.6	-0.3	0.5	-0.6	-0.4	-1.0	-1.1	-0.8	-1.3	0.7	2.9	-0.0	-1.2
Medication: Blood pressure	0.8	1.5	7.1	0.9	1.6	2.7	0.6	0.9	-0.1	0.2	-0.9	-1.3	1.7	-1.0	0.9	-0.8
Angina (self-reported)	0.9	1.2	5.5	1.4	0.4	2.3	0.4	0.5	0.5	0.0	-1.1	-1.7	1.2	0.6	0.8	-0.7
Migraine (self-reported)	1.4	1.7	5.9	0.5	-0.8	-0.1	-1.3	1.1	0.9	0.4	-1.9	-1.7	1.3	2.4	-1.5	-0.9
Medication: Ibuprofen	0.6	0.7	2.0	-1.4	0.3	0.6	0.7	0.8	-0.4	-0.3	1.3	0.1	-1.0	-0.1	0.4	1.4
Medication: Allopurinol	0.4	0.5	4.4	-0.4	-0.1	2.1	-0.1	0.8	-0.0	-0.7	0.4	0.4	-0.1	-0.1	-0.1	0.2
Medication: Omeprazole	0.7	0.9	2.9	0.8	-0.1	-0.4	0.1	-0.1	-1.7	-1.5	1.2	0.7	0.2	-0.5	-1.6	0.7
Medication: Seretide 50 evohaler	0.4	0.5	1.7	-0.5	0.3	1.2	-0.0	-0.6	-0.6	-1.1	1.3	0.2	0.5	0.9	0.2	-0.5
Mean time to correctly identify matches	0.7	1.3	3.4	1.9	-1.8	0.6	-1.1	1.1	1.0	-1.2	1.5	0.7	-0.3	-0.7	0.5	1.3
Heart disease (mother)	0.9	1.1	6.2	1.3	0.6	0.7	0.8	-0.5	-0.4	-0.8	-1.7	-2.5	1.0	0.1	0.9	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	4.9	-0.0	-0.2	-0.4	-0.3	2.2	0.9	-0.7	0.8	-0.7	0.7	1.1	1.0	-1.5
Whole body fat mass	0.4	1.7	5.6	0.0	1.2	2.3	-1.3	-1.0	-0.1	-0.5	-1.0	-1.4	2.4	0.9	0.1	-1.7
Leg fat mass (right)	0.4	1.6	9.5	0.1	1.4	3.1	-0.6	-0.4	0.3	0.4	-1.1	-1.1	1.9	0.7	0.7	-1.1
Arm predicted mass (right)	0.3	1.7	4.7	0.3	0.7	2.2	-1.5	-1.6	0.4	0.4	-2.2	-0.9	1.5	0.9	-1.2	-1.2
Pulse rate, automated reading	0.1	0.5	1.1	0.4	-0.2	-0.1	-0.1	-0.9	-0.9	-0.6	1.0	0.9	0.6	0.3	-1.1	0.8
Alcohol intake frequency.	0.5	1.1	4.1	0.2	1.9	0.5	0.8	0.8	1.3	1.3	0.1	-1.1	0.2	0.5	2.0	-0.3
Comparative height size at age 10	0.3	1.6	4.4	0.2	0.1	-0.4	-1.4	-2.1	-1.3	-0.6	-0.6	-0.9	1.0	1.7	-1.9	-2.0
Number of full sisters	1.5	1.8	7.1	2.2	1.9	0.1	-0.6	1.4	2.7	1.4	-0.2	0.2	-0.5	-0.7	1.5	0.3
Suffer from ‘nerves’	0.5	0.8	3.3	-0.6	0.5	1.8	1.0	0.9	0.8	0.3	-0.0	1.2	-0.3	-0.5	0.6	1.5
Overall health rating	0.8	1.8	7.6	2.8	-0.9	1.7	-1.3	1.2	2.0	-1.5	-0.6	-0.9	0.9	0.8	0.4	0.2
Chest pain or discomfort	0.9	1.3	5.2	0.9	-0.1	1.0	0.2	2.2	2.3	-1.0	0.3	-1.9	0.3	0.7	0.4	-0.2
Had major operations	1.9	2.2	7.0	-0.4	-2.7	-0.9	-0.5	1.8	2.3	-2.2	1.3	0.7	-1.0	0.4	-1.1	1.5
Age at last live birth	0.9	1.3	8.5	-2.9	-1.2	0.1	-1.0	0.0	0.1	-1.1	0.7	1.1	-1.3	-0.1	-0.6	0.8
Family relationship satisfaction	1.0	1.2	7.4	2.2	0.1	0.6	0.4	-1.0	-0.2	-0.1	2.7	0.0	-0.9	-0.9	-0.1	0.7
Leg pain on walking	0.7	0.8	6.2	0.6	0.1	-0.4	-0.0	-1.1	-1.5	-0.2	-2.5	-0.4	0.3	0.2	0.2	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	4.2	-1.8	-0.1	1.2	-0.3	0.7	1.7	-0.9	-0.2	0.8	-0.5	2.0	-0.6	-0.6
Commuting to job workplace: Car/motor vehicle	2.0	2.3	6.2	0.4	0.6	1.4	0.9	-1.0	-2.2	-0.9	-2.5	-1.7	1.9	0.7	0.6	-2.5
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	7.0	-2.6	1.5	0.4	2.2	0.2	0.4	0.4	1.5	1.2	0.0	0.4	0.2	0.5
Medication: Aspirin	0.7	0.9	4.8	0.6	1.1	1.6	-0.0	2.2	0.5	-0.5	1.3	-0.1	0.9	-0.5	-0.3	0.0
Supplements: Vitamin C	0.4	0.5	1.1	0.7	-1.1	-0.2	0.4	-0.4	-0.9	-0.6	-0.1	1.0	0.0	-0.8	-0.4	1.0
Knee pain experienced in last month	0.9	1.5	6.4	0.5	-0.4	1.6	0.2	2.0	2.5	0.1	-0.2	-0.6	0.6	-0.2	1.7	1.3
Hypertension (Self-reported)	0.5	1.5	3.3	1.5	1.7	1.3	-0.3	1.4	1.2	1.0	-0.5	-0.8	1.7	-1.0	1.8	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	3.6	-1.3	-0.2	0.4	1.1	0.2	0.3	-1.9	-0.3	0.5	0.1	-0.1	-0.1	1.3
Illnesses of father: Heart disease	0.2	0.3	1.0	0.5	0.2	1.0	-0.1	-0.1	-0.5	0.8	-0.6	-0.7	0.1	-0.1	0.9	-0.4
Illnesses of siblings: Diabetes	0.4	0.4	2.1	-0.4	-1.0	1.1	0.2	0.4	0.4	-0.5	-0.8	-1.4	0.0	-0.1	0.3	0.3
Smoking status: Previous	0.6	0.9	2.7	0.2	-0.7	-1.0	-0.1	0.8	1.1	-1.5	1.0	-0.2	0.4	1.6	-1.1	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	2.1	0.2	-0.6	-1.1	-1.5	0.1	0.5	-0.7	-0.4	0.4	-0.7	0.6	-0.9	-0.5
Whole body fat-free mass	0.3	1.9	4.2	0.5	0.6	2.1	-2.1	-0.9	1.1	0.2	-2.0	-1.1	1.8	1.2	-1.5	-1.5
Leg fat-free mass (right)	0.3	1.8	4.3	0.6	0.7	2.1	-2.0	-1.0	0.6	0.0	-2.0	-1.2	1.7	0.7	-1.4	-1.5
Arm fat percentage (left)	0.2	0.9	3.1	-0.5	0.8	1.7	-0.3	-0.8	-0.3	-1.2	-0.4	-0.9	1.7	0.1	0.8	-0.7
Average weekly red wine intake	0.4	0.6	2.3	0.7	0.6	-1.4	0.6	0.1	-0.6	-0.2	-0.5	0.4	0.8	-0.7	-0.8	-1.5
Handedness (chirality/laterality): Left-handed	1.3	1.5	5.3	1.0	1.0	0.4	-0.5	-1.8	-1.5	-0.5	-0.7	-0.5	1.2	1.9	-0.8	-2.3
Mood swings	0.2	0.3	1.4	0.1	-0.3	1.2	-0.0	-0.1	-0.6	-1.0	-0.5	-0.1	0.1	0.8	-0.7	-0.1
Loneliness, isolation	0.9	1.2	2.9	0.7	-1.5	-0.1	-1.1	1.0	0.7	-1.4	1.3	1.7	-1.2	-0.2	-1.0	1.0
Long-standing illness, disability or infirmity	1.1	1.6	3.7	1.4	-1.9	0.6	-1.9	0.1	1.3	-1.2	-1.8	-0.9	1.3	1.4	0.5	0.1
Ever had bowel cancer screening	1.2	1.4	5.2	1.8	0.7	-0.3	-0.3	0.8	0.5	0.4	-1.0	-1.4	2.1	0.9	0.2	-2.3
Diabetes diagnosed by doctor	1.3	2.1	6.6	1.4	1.2	1.3	-1.3	2.6	2.5	0.9	-0.8	-0.8	1.8	-0.7	1.4	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	4.6	0.2	-0.1	0.3	-1.1	-1.4	-1.4	-0.1	-2.1	-0.7	0.6	1.1	-0.6	-1.1
Friendships satisfaction	0.9	1.1	5.1	0.5	-0.0	-0.6	-0.1	0.6	0.8	-1.2	2.2	0.3	-0.9	-1.0	0.6	2.0
Qualifications: nursing, teaching	0.8	1.3	4.7	1.3	-2.0	-1.2	-0.9	0.8	0.8	-1.4	-2.2	-0.9	0.2	0.1	0.4	0.0
Commuting to job workplace: Walk	0.7	0.8	2.5	-0.2	1.0	0.6	-0.0	-1.1	-0.8	1.6	1.4	1.1	-0.5	-0.9	-0.5	0.5
Eye problems/disorders: Cataract	0.7	0.8	3.4	1.4	1.2	0.5	1.9	0.3	-0.4	1.2	0.3	-0.1	-0.1	0.1	1.1	0.4
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	6.3	-1.8	-0.9	1.0	-0.7	0.7	0.7	0.5	0.6	1.1	-2.5	-0.9	-0.0	1.0
Medication for cholesterol	0.4	0.6	2.3	-0.3	-0.9	-0.0	-1.2	-0.9	-0.2	0.3	-0.1	-0.7	-0.5	0.7	-1.5	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	5.0	-0.1	-1.3	-1.8	0.2	-1.2	-0.5	-0.1	0.5	1.4	-0.6	-1.0	-2.2	0.2
Back pain experienced in last month	0.4	0.6	1.8	-0.8	0.5	1.2	0.3	-0.1	-1.2	-1.1	-1.3	-0.7	0.1	0.2	-0.1	-0.2
Mineral and other dietary supplements	0.9	1.3	8.0	-1.3	-0.0	-1.0	-2.8	-0.7	-0.1	0.6	0.4	-1.6	0.1	1.1	0.2	-0.7
Breast cancer (self-reported)	0.5	0.6	2.3	-1.5	1.2	0.0	0.8	-0.3	-0.6	0.2	0.2	0.1	0.6	0.2	1.0	1.0
Asthma (self-reported)	0.2	0.4	1.6	0.6	0.6	0.7	0.5	-1.3	-0.9	0.8	0.3	-0.0	0.1	0.7	0.3	-0.3
Osteoporosis (self-reported)	0.5	0.6	1.7	-1.3	-0.5	-0.2	-0.1	-1.1	-1.1	-1.2	-0.2	-0.4	1.1	0.7	0.3	0.2
Osteoarthritis (self-reported)	0.9	1.1	3.8	1.0	0.5	1.6	-0.7	-1.0	-0.2	-0.0	-1.2	-0.1	1.1	1.5	-0.9	-1.9
Medication: Aspirin	0.9	1.1	5.3	0.2	1.2	1.8	-0.3	2.3	1.1	-0.6	1.2	-0.5	1.0	-0.4	-0.0	-0.2
Medication: Gliclazide	0.6	0.7	2.0	0.6	0.8	-0.3	-1.0	0.9	0.8	1.4	-0.3	0.5	-0.8	-1.1	1.0	0.6
Illnesses of father: None of the above (group 1)	1.0	1.2	3.7	-1.7	-0.9	-0.5	1.2	-0.0	0.3	-1.2	-0.2	1.8	-1.3	-0.8	-0.4	1.9
Smoking status: Current	0.3	0.5	1.4	0.9	0.1	-0.3	-0.4	-0.1	-1.2	0.4	-0.6	-1.1	0.5	-0.7	0.4	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.9	0.5	-1.4	0.2	0.3	-0.0	-1.4	-0.6	0.7	-0.0	-1.7	-0.9	-1.6	0.2
Whole body water mass	0.3	2.0	4.2	0.4	0.6	2.0	-2.0	-1.1	1.0	0.3	-2.0	-1.1	1.8	1.2	-1.6	-1.6
Leg predicted mass (right)	0.3	1.8	4.5	0.6	0.7	2.1	-2.0	-1.0	0.7	0.1	-2.0	-1.2	1.7	0.7	-1.4	-1.5
Arm fat mass (left)	0.4	1.5	5.3	-0.4	1.0	2.3	-1.1	-1.0	0.0	-1.0	-1.3	-1.3	2.2	0.7	0.3	-1.3
Number of self-reported non-cancer illnesses	0.4	0.7	3.5	0.6	-0.7	0.2	-1.2	-0.6	-1.3	-0.5	-1.9	-0.4	0.9	-0.3	-0.4	-0.3
Average weekly champagne plus white wine intake	2.3	3.2	6.8	-2.6	-1.2	1.7	1.7	-1.6	-0.5	-2.4	1.5	2.2	-2.3	-1.4	-1.2	2.0
Miserableness	0.6	1.1	5.2	-0.0	0.4	2.3	1.2	1.3	0.4	-0.1	-1.1	0.4	1.0	1.5	0.6	0.8
Guilty feelings	0.7	1.1	3.4	1.8	-1.3	1.7	0.1	0.4	0.0	-0.7	-0.9	-0.4	1.1	0.1	0.9	1.4
Wears glasses or contact lenses	0.6	0.7	3.9	2.0	0.6	-0.5	0.9	-0.0	-0.4	0.0	0.8	-0.1	1.5	-1.0	0.2	0.0
Ever taken oral contraceptive pill	1.5	1.6	4.9	-1.4	-0.7	-0.9	0.8	-1.8	-1.6	-1.1	-0.9	0.8	-1.5	1.3	-2.2	-0.1
Hearing aid user	1.1	1.2	3.3	1.5	-1.0	-0.9	-1.2	-1.5	-1.6	-1.0	1.8	-0.6	0.6	-0.3	-0.6	0.2
Mother’s age at death	0.3	0.4	1.1	0.1	-0.8	-0.3	0.3	-1.0	-1.1	0.6	0.4	-0.8	-0.5	-0.4	-0.3	-0.3
Financial situation satisfaction	0.9	1.1	4.5	-0.4	0.3	0.8	0.2	0.9	1.2	0.8	2.1	1.5	-0.0	-0.6	1.1	1.5
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.7	0.3	-0.5	1.0	-0.9	-0.3	-0.6	-0.4	-1.6	0.0	1.5	1.4	1.0	-0.6
Commuting to job workplace: Public transport	2.4	2.8	7.8	-1.7	-2.2	-0.8	-0.6	1.4	1.9	-1.1	2.8	1.2	-1.9	-1.5	0.4	2.5
Eye problems/disorders: Glaucoma	1.8	2.1	6.8	2.2	0.7	-1.9	-0.2	2.3	2.6	1.4	1.6	0.2	-0.5	-0.9	-1.0	-0.1
Medication: Blood pressure	0.3	0.5	1.9	-0.0	0.8	-0.4	0.3	0.3	1.4	-0.3	0.1	0.2	0.1	-1.4	1.2	0.8
Pain type(s) experienced in last month: Hip pain	0.5	0.6	2.6	-1.1	-0.3	0.2	-0.2	-0.7	0.2	0.4	-1.2	-0.3	0.2	1.6	-0.6	-1.3
Supplements: Fish oil (including cod liver oil)	0.7	0.9	3.6	1.7	-0.5	1.4	1.9	-0.0	-0.3	-1.1	0.2	1.0	-0.2	-0.3	-0.7	0.2
High cholesterol (Self-reported)	0.5	0.9	5.2	0.2	-0.3	-0.4	-1.0	0.9	-1.2	-2.3	-0.4	-0.5	-0.0	-1.4	-0.9	-0.6
Medication: Bendroflumethiazide	1.0	1.5	6.3	0.8	-0.8	-1.0	1.6	0.3	0.0	-0.1	0.5	1.4	-1.3	-2.5	0.1	2.1
Medication: Paracetamol	1.0	1.5	7.7	-2.1	-0.1	1.0	-0.6	2.8	1.0	0.1	0.8	1.1	-0.7	0.3	1.4	0.9
Medication: Lisinopril	0.2	0.3	0.7	0.5	0.7	0.2	0.8	-0.2	0.5	0.3	0.8	-0.2	0.8	-0.6	-0.3	-0.6
Medication: Atorvastatin	0.8	1.0	3.4	1.8	0.4	1.5	0.0	1.5	0.3	-0.6	-1.1	-0.5	1.0	0.6	0.3	-0.9
Illnesses of father: High blood pressure	0.3	0.4	1.9	0.1	0.6	-0.4	-1.1	0.7	0.1	1.4	0.7	-0.5	0.4	-0.3	0.2	-0.2
Alcohol drinker status: Never	0.8	0.9	3.0	-0.0	1.1	0.8	1.3	0.3	0.6	0.9	0.6	1.7	-0.9	-1.4	-0.9	0.3
Ever smoked	0.4	0.8	3.2	0.8	-1.1	-1.8	-0.5	-0.6	-1.1	-0.8	1.2	-0.3	0.7	-0.4	-0.7	0.3
Basal metabolic rate	0.4	2.1	4.6	0.4	0.7	2.1	-2.1	-1.1	0.8	0.1	-2.1	-1.2	2.0	1.2	-1.4	-1.7
Leg fat percentage (left)	0.5	1.7	8.1	-0.5	1.0	2.9	0.3	-1.0	-1.0	-0.5	-1.4	-0.9	2.0	0.5	1.6	-0.4
Arm fat-free mass (left)	0.5	2.6	6.5	-0.0	0.8	2.4	-2.0	-1.3	0.6	0.2	-2.4	-1.6	2.5	1.7	-1.0	-1.7
Number of operations (self-reported)	0.7	1.1	3.2	0.8	-0.7	-1.0	-0.5	1.3	1.8	-1.7	-0.2	0.9	0.4	0.1	-1.6	0.7
Average weekly beer plus cider intake	1.3	1.9	6.9	0.4	2.0	1.1	0.4	-0.6	-0.4	0.7	-1.8	-1.8	2.6	0.5	0.7	-2.0
Irritability	0.7	1.2	6.9	-0.5	-0.9	2.6	-0.3	-0.8	-1.9	-0.4	0.3	1.1	0.8	0.3	-1.0	-0.3
Risk taking	1.0	1.5	4.9	-0.1	-0.1	0.5	0.2	-2.2	-2.2	-1.2	-0.6	-0.8	-0.1	0.1	-1.9	-1.9
Ever had prostate specific antigen (PSA) test	1.4	1.6	11.2	0.9	-0.0	0.2	0.0	-0.6	0.0	-0.4	-0.9	-0.8	1.4	0.6	-2.0	-3.4
Fractured/broken bones in last 5 years	1.8	2.3	7.4	-0.9	-2.7	-1.9	0.3	-1.8	-0.2	-1.7	1.1	1.1	-2.3	-1.4	-0.3	1.4
Age started oral contraceptive pill	0.8	1.0	3.7	-0.9	0.1	-0.9	0.1	1.4	1.1	0.1	1.9	0.9	-1.2	-1.2	0.8	0.6
Diastolic blood pressure, automated reading	0.2	0.7	3.1	-0.8	0.5	1.8	-0.1	-0.6	-0.9	0.9	-0.8	0.7	1.1	0.8	-0.7	-0.7
Ever depressed for a whole week	0.3	0.3	1.2	-1.1	0.1	0.7	-0.6	-0.5	0.3	0.4	0.2	0.4	0.3	0.7	-0.5	0.8
Unable to work because of sickness or disability	0.4	0.5	2.1	0.1	-1.1	1.5	-0.6	-0.0	-0.6	-0.9	0.0	-0.1	0.1	0.2	-0.9	0.1
Commuting to job workplace: Cycle	1.0	1.2	4.9	0.2	0.8	-1.6	0.3	0.2	0.0	1.1	2.2	-0.3	-1.3	-1.2	-0.2	1.6
Myopia	1.0	1.5	6.8	2.6	-0.4	-0.7	0.7	-2.6	-0.9	-0.4	0.0	-0.8	0.4	1.1	0.9	-0.8
Vascular/heart problems diagnosed by doctor	0.4	1.2	2.9	-1.3	-1.5	-1.3	0.1	-1.1	-0.8	-0.4	0.8	0.6	-1.7	1.1	-1.6	0.0
Cholesterol lowering medication	0.6	0.9	3.8	0.6	0.9	0.9	-0.0	1.9	0.6	-0.4	0.3	0.0	1.2	-1.1	1.6	0.3
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.9	1.4	-0.4	-0.4	0.2	-0.1	-0.8	-1.2	1.1	0.4	-0.0	-0.0	-1.3	0.8
Pain experienced in last month	0.5	0.8	3.0	-0.2	-0.2	-0.8	-0.2	-1.3	-1.7	0.1	0.2	0.4	-1.1	-1.6	-0.7	-0.4
Supplements: Calcium	0.5	0.5	2.5	1.1	-0.6	-0.3	0.8	-0.4	-0.1	0.0	1.1	-0.1	-0.3	-0.8	-0.2	1.6
Basal cell carcinoma (self-reported)	1.1	1.3	5.8	1.6	-0.8	-2.4	0.3	-1.4	0.2	-0.3	1.1	-2.0	0.6	0.1	-0.0	0.0
Heart attack/myocardial infarction (self-reported)	0.7	1.0	4.7	-0.4	2.2	-0.7	0.7	-0.1	0.7	0.9	0.0	-1.6	0.8	-1.0	1.1	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	4.8	0.5	-0.4	2.2	-0.8	0.2	0.0	-1.6	-0.7	1.1	-0.3	-0.3	-0.3	-0.2
Heart disease (siblings)	0.7	0.8	2.4	1.0	1.6	1.0	1.5	0.3	0.1	1.0	0.3	-1.5	0.1	-0.3	0.4	0.4
Alcohol drinker status: Previous	0.5	0.5	1.7	-0.7	0.2	-1.2	-0.4	-0.5	0.9	-0.2	0.8	-0.5	0.7	0.6	1.3	-0.3
Pack years of smoking	1.0	1.4	5.6	-1.7	-0.4	0.9	0.7	-2.4	-1.8	0.1	-0.3	0.2	-1.7	-1.1	-0.9	0.7
Impedance of whole body	0.2	1.0	5.9	0.0	-0.2	-2.4	0.4	0.2	-1.2	0.4	1.7	0.9	-1.1	-0.1	0.1	0.3
Leg fat mass (left)	0.4	1.7	9.6	0.1	1.3	3.1	-0.7	-0.6	0.1	0.1	-1.6	-1.1	2.1	0.7	0.7	-1.0
Arm predicted mass (left)	0.5	2.7	6.8	0.2	0.7	2.4	-2.0	-1.3	0.6	0.0	-2.5	-1.8	2.6	1.6	-0.9	-1.7