Hub : Genes

ABCC8

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1960	0.0360	1.2e-13	0.084	0.118	0.168	0.143	0.167	2.3e-10	3.9e-14	5.8e-20	5.3e-17	7.0e-20
2	ROSMAP	Brain Pre-frontal Cortex	0.2501	0.0411	0.0e+00	0.144	0.154	0.221	0.204	0.222	5.2e-18	2.4e-19	6.6e-28	1.3e-25	4.8e-28
3	TCGA	Breast Invasive Carcinoma	0.0546	0.0189	1.2e-06	0.050	0.037	0.041	NA	0.044	1.5e-10	3.5e-08	7.8e-09	NA	1.7e-09
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0596	0.0289	1.0e-02	0.010	0.007	0.005	NA	0.006	2.5e-02	4.5e-02	8.8e-02	NA	6.5e-02
5	TCGA	Brain Lower Grade Glioma	0.1163	0.0385	7.1e-07	0.047	0.071	0.075	NA	0.088	4.2e-06	1.8e-08	6.3e-09	NA	3.2e-10
6	TCGA	Lung Adenocarcinoma	0.0936	0.0410	3.6e-04	0.008	0.047	0.013	NA	0.015	3.9e-02	3.1e-06	9.6e-03	NA	5.7e-03
7	TCGA	Lung Squamous Cell Carcinoma	0.0574	0.0256	3.0e-03	0.004	0.015	0.026	NA	0.012	1.1e-01	6.7e-03	5.3e-04	NA	1.4e-02
8	TCGA	Prostate Adenocarcinoma	0.1001	0.0407	1.8e-04	0.063	0.030	0.048	NA	0.024	3.8e-07	3.5e-04	8.5e-06	NA	1.4e-03
9	TCGA	Testicular Germ Cell Tumors	0.2010	0.0680	5.7e-04	0.077	0.077	0.029	NA	0.057	1.1e-03	1.1e-03	3.4e-02	NA	4.6e-03
10	TCGA	Thyroid Carcinoma	0.3370	0.0620	2.4e-13	0.122	0.168	0.173	NA	0.168	6.6e-12	4.1e-16	1.3e-16	NA	4.3e-16

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	1.3	2.1	4.9	1.9	1.6	2.2	-1.3	1.3	0.3	-0.3	1.4	2.1	0.4
Bipolar Disorder or Schizophrenia	2.2	5.3	11.9	2.1	1.9	3.4	-0.0	3.2	-0.3	0.2	3.1	2.1	2.8
Depressed Affect (Nagel 2018)	1.6	3.5	8.8	0.5	0.0	2.5	0.3	3.0	1.4	1.9	2.9	0.5	2.2
Depression (Nagel 2018)	2.5	3.7	8.0	-0.4	-1.2	2.2	2.3	2.2	1.2	1.7	2.8	1.2	2.6
Intelligence (Savage-Jansen 2018)	1.4	4.4	14.3	-1.7	-0.6	-2.8	-0.2	-3.8	-0.9	-1.2	-2.8	-0.9	-2.8
Neuroticism (Nagel 2018)	0.4	0.9	2.6	0.1	0.6	1.3	0.5	1.4	0.0	0.5	1.6	0.3	1.5
Schizophrenia (2018)	2.0	4.1	10.6	1.2	1.1	2.6	1.0	3.1	-0.6	0.5	2.9	1.0	3.3
Schizophrenia vs Biploar Disorder	0.4	0.5	2.0	0.3	0.5	0.5	1.0	0.5	0.1	0.5	0.9	-0.1	1.4
Worry (Nagel 2018)	0.3	0.5	1.9	-0.2	0.9	-0.2	0.0	-0.3	-1.4	-1.3	-0.3	-0.7	-0.3
Alzheimer’s Disease (in mother)	1.0	1.2	2.5	-0.5	-0.6	1.6	1.1	1.2	1.4	0.8	1.3	-0.8	1.2
Alzheimer’s Disease (in father)	1.6	1.7	3.9	2.0	1.7	0.9	-2.0	1.5	-0.3	-0.6	1.3	-1.2	0.1
Alzheimer’s Disease (including proxy)	1.5	2.2	5.6	-0.0	-0.4	2.4	0.8	2.2	1.3	0.4	2.4	-0.0	1.6
Crohns Disease (2017)	1.1	2.4	5.3	2.3	2.1	1.1	-1.5	1.8	-0.2	0.8	1.6	2.0	1.1
Irritable Bowel Disease (IBD)	1.7	4.1	11.4	3.4	3.0	1.6	-0.5	1.9	-0.4	0.6	2.1	2.5	1.7
Ulcerative Colitis (UC)	1.7	3.1	9.6	3.1	2.8	1.4	0.4	1.4	-0.2	0.5	1.9	1.9	1.5
Major Depression (MDD)	0.6	0.8	2.1	0.6	-0.4	1.3	1.5	0.4	0.5	0.2	1.0	-0.5	1.4
Reaction Time	0.1	0.3	0.5	0.6	0.7	0.7	0.4	-0.3	-0.4	-0.6	0.6	-0.5	-0.1
Verbal and Numeric Reasoning (VNR)	1.2	2.9	8.8	-1.5	0.1	-2.7	0.4	-3.0	-0.6	-0.5	-2.4	-0.6	-1.9
Breast Cancer	2.2	5.2	10.8	-1.8	-2.0	-2.0	-0.7	-3.3	-1.1	-2.4	-2.7	-2.6	-3.0
Ovarian Cancer	0.9	1.1	2.7	-1.0	-1.2	1.2	0.6	0.9	1.6	1.1	1.1	0.3	1.0
Prostate Cancer	0.3	0.4	1.1	0.8	1.0	-0.1	-0.8	0.2	0.8	-0.0	-0.3	0.7	-0.3
Age at First Birth	1.3	1.9	4.5	0.5	0.5	-1.6	-0.7	-2.0	-1.2	-1.9	-2.1	0.1	-1.5
Bipolar Disorder (2011)	0.6	0.6	2.1	-0.1	0.3	-0.2	-0.2	1.0	-1.3	-1.4	-0.4	0.6	-0.2
Body Mass Index (BMI) (2010)	0.7	0.9	2.0	1.2	0.4	1.4	0.1	1.2	0.4	-0.0	1.2	-1.0	1.3
Coronary Artery Disease (CAD)	0.5	0.6	2.4	-0.7	-0.2	0.0	1.2	-0.2	-1.2	-1.5	-0.3	-0.7	0.3
Crohns Disease (2012)	0.9	1.4	3.8	1.4	1.5	-0.8	-1.8	-0.1	-1.1	-0.1	-0.5	2.0	-0.5
Mean Putamen Volume	2.8	3.2	7.7	0.5	0.9	-2.4	-0.1	-2.5	-1.3	-1.7	-2.8	-1.0	-2.4
Fasting Glucose	0.1	0.1	0.9	-0.3	0.3	-0.0	-0.4	-0.2	-0.9	-0.2	0.2	-0.3	0.3
HbA1C	0.8	0.8	2.3	-0.6	-0.6	1.1	-0.5	0.7	0.4	1.5	1.1	-1.4	0.3
HDL Cholesterol	0.5	0.9	2.6	-0.6	-0.4	1.1	1.6	1.4	0.1	-0.1	0.6	1.2	1.0
LDL Cholesterol	0.5	0.7	2.7	-0.5	-0.9	0.7	0.6	0.2	1.7	0.2	1.3	0.8	0.6
Lupus	0.4	0.6	1.3	0.6	-0.3	0.7	0.6	-1.0	0.8	-0.7	-0.2	1.0	-1.1
Neuroticism (2016)	0.7	0.9	5.7	-0.5	-0.5	-0.3	-0.9	-0.9	-0.9	-0.2	-0.3	-2.4	-0.7
Primary Biliary Cirrhosis	1.7	2.4	7.9	2.8	1.4	2.1	0.1	1.6	0.6	0.1	2.0	-0.2	1.8
Rheumatoid Arthritis	0.5	0.7	2.4	-1.2	-1.5	0.1	1.4	-0.1	0.6	0.6	0.2	-0.5	0.5
Schizophrenia (2014)	1.7	3.6	8.6	2.2	1.8	2.9	0.1	2.4	-1.0	0.1	2.7	0.6	2.4
Triglycerides	0.2	0.3	1.0	0.6	0.1	-0.4	-0.3	-0.9	0.0	-0.3	-0.4	-1.0	-0.8
Type 2 Diabetes (T2D) (2012)	1.0	1.2	3.8	-1.1	-1.1	-0.1	1.9	0.4	-1.5	-1.7	-0.5	0.5	-0.3
Ulcerative Colitis	1.8	2.6	9.9	2.9	3.1	0.5	-0.7	0.6	-1.3	-1.2	0.1	1.8	-0.1
Blood Eosinophil Count	0.4	2.9	10.7	-3.3	-2.8	-0.9	-0.1	-1.0	1.2	0.6	-1.0	-2.2	-0.9
Blood Platelet Count	0.2	2.3	6.2	1.1	1.5	-1.1	-2.5	-1.2	-1.8	-1.0	-0.8	-2.1	-0.9
Blood Red Count	0.4	3.4	6.0	-1.8	-2.1	-2.0	-1.8	-2.0	0.5	0.2	-2.3	-2.5	-1.8
Blood White Count	0.1	0.8	1.8	-1.3	-1.1	-1.3	-0.7	-0.7	-0.6	-0.0	-0.8	-1.0	-0.7
Heel T-Score	0.7	5.5	17.1	-0.1	0.6	-2.5	-2.2	-2.2	-2.1	-2.7	-3.1	-0.5	-4.1
BMI	0.3	1.7	4.6	1.4	0.2	2.1	-1.9	0.6	1.4	0.4	1.2	-1.8	0.7
Height	1.0	19.0	64.3	-3.9	-4.7	2.1	8.0	3.4	3.4	1.9	2.7	5.6	4.3
Waist Hip Ratio (WHR)	0.3	1.4	3.7	-1.9	-0.5	-1.7	0.8	-1.1	-0.1	1.3	-0.7	1.4	-0.8
Systolic Blood Pressure	1.5	7.8	24.0	-4.9	-2.9	-2.7	3.5	-1.8	-0.0	0.1	-2.9	2.9	-2.3
Smoking Status	0.5	1.2	2.6	1.4	1.2	1.6	-1.1	-0.2	1.0	0.7	0.8	-1.6	0.7
Allergy or Eczema	1.0	2.7	6.6	0.5	0.9	-1.8	-2.6	-1.8	-1.1	-1.0	-1.7	-1.5	-2.3
Cardiovascular Disease	0.3	1.0	3.1	-1.8	-1.6	-0.0	1.5	-0.3	0.6	0.1	-0.4	1.2	-0.3
Hypothyroidism (self reported)	0.3	0.8	2.4	-0.2	-0.7	0.3	-0.1	1.6	0.9	1.3	1.2	0.3	1.0
Respiratory disease	0.5	1.1	6.4	0.3	-0.2	0.0	-2.5	-0.8	0.6	1.1	0.3	0.8	-1.1
Type 2 Diabetes (T2D) (2018)	0.9	1.7	4.0	-1.4	-1.2	1.1	0.5	0.4	1.3	2.0	1.6	1.8	0.3
Lung FEV1/FVC ratio	0.3	1.4	6.9	-1.1	-2.6	0.6	1.3	0.3	0.9	0.1	0.5	-1.3	0.9
Lung FVC	0.1	0.7	1.7	-0.3	-0.4	-1.0	-0.9	-0.8	0.6	-0.8	-1.3	-1.2	-0.7
Neuroticism	0.6	1.3	3.4	0.3	0.3	1.8	0.7	1.8	0.3	-0.2	1.6	-0.4	1.8
Chronotype (morning person)	0.8	1.7	7.2	0.9	2.1	-1.3	-1.6	0.2	-2.7	0.3	-0.4	0.6	-0.3
Hair Pigment	0.1	3.5	9.1	2.1	3.0	0.1	-2.7	2.3	-3.0	-0.4	0.3	0.6	-0.1
Tanning	0.1	1.1	5.4	-0.2	-0.2	1.1	0.6	0.4	2.3	0.7	1.0	-0.4	1.5
Hand grip strength (left)	1.1	2.8	8.6	-0.6	-0.1	-2.8	-1.4	-1.6	-0.2	0.1	-2.6	-0.1	-2.9
Number of treatments/medications taken	0.1	0.2	0.6	-0.3	-0.5	-0.7	0.5	-0.8	-0.1	-0.2	-0.4	0.4	-0.1
Average weekly spirits intake	0.8	0.9	2.8	0.4	0.4	1.4	0.6	1.7	-0.6	0.6	0.8	1.4	0.8
Sensitivity / hurt feelings	0.3	0.5	1.9	-0.0	0.6	0.7	0.3	0.6	-0.1	0.2	1.1	0.6	1.4
Frequency of depressed mood in last 2 weeks	0.5	0.8	3.1	0.1	-0.9	1.0	0.5	1.0	0.2	0.5	1.8	0.3	1.1
Hearing difficulty/problems: Yes	0.5	0.8	2.3	0.2	0.3	0.3	-0.3	1.4	1.1	1.3	0.6	1.5	-0.5
Relative age of first facial hair	1.3	2.7	6.3	0.7	-0.3	-1.1	-2.2	-1.5	-0.7	-2.3	-1.3	-2.5	-2.1
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	4.5	-0.8	-2.1	0.7	0.9	-0.3	1.6	0.5	1.0	1.2	0.8
Ever used hormone-replacement therapy (HRT)	0.9	1.2	3.6	0.0	0.0	-1.0	-1.6	-1.6	-0.5	0.0	-0.9	-1.9	-0.9
Ever had hysterectomy (womb removed)	1.0	1.1	3.3	-0.7	-1.3	-0.0	1.8	0.0	1.2	1.3	0.1	1.0	1.1
Systolic blood pressure, automated reading	0.7	2.0	6.9	-1.8	-1.7	0.1	2.4	0.1	0.9	-0.1	-0.8	2.6	-0.4
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	4.6	-2.0	-2.1	-0.5	0.6	0.2	1.6	1.8	0.1	1.7	0.0
Angina	0.3	0.4	1.0	1.0	0.4	0.8	0.7	0.1	0.6	-0.2	0.2	-0.6	0.6
Medication for hormone replacement therapy	0.9	1.0	2.2	-1.0	-0.9	-1.0	-0.2	-1.5	-1.4	-1.0	-0.9	-0.4	-0.7
Vitamin and mineral supplements	1.0	1.4	6.6	-1.2	-1.0	-0.7	1.5	0.0	-0.1	-0.4	-1.3	2.6	-0.4
Supplements: Zinc	0.8	0.8	2.5	0.1	0.0	-1.5	1.0	-1.0	-1.6	-0.8	-0.8	-0.3	-0.7
Medication: Co-codamol	0.6	0.6	2.0	1.4	0.5	0.7	-0.3	-0.8	-0.2	-0.5	0.3	-1.3	0.9
Medication: Metformin	0.6	0.8	3.1	-1.2	-1.3	0.3	1.0	0.0	0.5	0.1	0.5	1.8	-0.1
Diabetes (father)	0.4	0.5	3.5	-0.1	0.4	0.1	0.6	0.4	-1.9	-0.9	0.1	0.6	-0.0
Diabetes (mother)	0.5	0.6	1.7	-1.3	-0.8	-0.7	1.3	-0.7	0.3	-0.0	-0.8	0.3	-0.8
Severe depression (siblings)	0.3	0.4	0.9	0.7	0.9	-1.0	-0.1	-0.5	-0.9	0.0	-0.5	0.1	-0.2
Pack years adult smoking proportion	1.5	2.3	6.7	1.0	0.8	2.6	0.9	2.2	0.5	-0.5	2.2	0.7	1.7
Impedance of leg (right)	2.3	11.2	26.4	-3.0	-1.1	-5.1	-1.5	-3.9	-2.9	-2.3	-4.7	-1.4	-4.4
Leg fat-free mass (left)	1.8	9.6	17.0	1.2	-0.5	4.1	2.7	3.6	3.6	2.8	4.0	2.2	4.0
Trunk fat percentage	0.1	0.2	0.8	-0.2	-0.7	0.3	-0.0	-0.8	0.5	0.1	-0.4	-0.9	-0.1
Hand grip strength (right)	0.3	0.9	3.7	-0.3	-0.7	-1.3	-1.3	-0.7	0.1	0.4	-1.0	0.1	-1.9
Townsend deprivation index at recruitment	0.9	1.2	3.8	2.0	1.4	1.3	-0.2	0.4	-0.2	0.2	1.4	-0.8	1.3
Current tobacco smoking	1.5	2.5	8.0	0.7	0.1	2.8	0.7	1.1	2.1	1.1	1.9	0.9	2.2
Average weekly fortified wine intake	2.0	2.4	5.8	-0.7	1.5	-2.4	-1.5	-1.1	-1.3	-0.3	-2.0	-1.9	-1.5
Maternal smoking around birth	2.2	3.2	7.9	1.6	1.6	2.0	0.2	2.0	1.1	1.8	2.0	1.7	2.8
Fed-up feelings	0.5	0.9	2.4	-0.1	0.0	1.0	0.1	1.4	-0.1	0.7	1.6	-0.8	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.7	7.5	-0.0	-0.5	1.9	1.6	1.5	0.7	1.4	2.6	0.9	2.7
Relative age voice broke	0.5	0.7	3.9	-0.3	-0.6	0.1	-1.0	0.1	1.1	-0.7	-0.3	-2.0	-0.6
Taking other prescription medications	0.5	0.8	2.8	0.6	-0.4	0.5	-0.3	0.1	1.5	1.7	0.9	0.4	1.1
Age when periods started (menarche)	0.7	1.8	4.4	2.1	2.0	1.3	0.4	1.2	0.1	-1.1	1.0	1.0	1.6
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.6	0.4	0.6	-0.4	0.5	-0.7	-0.5	-0.5	-0.6	0.6	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	4.8	1.8	2.1	-0.8	-2.0	-0.7	-2.2	-1.3	-1.1	-0.2	-1.6
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	3.9	-0.2	-0.2	0.3	-2.0	-0.1	0.4	-0.0	0.4	-0.1	-0.5
Qualifications: CSEs or equivalent	1.3	1.8	3.9	0.7	0.8	2.0	-0.8	1.3	0.8	1.7	1.9	1.2	1.1
Serious illness, injury or assault to yourself	0.6	0.7	3.6	0.4	-1.0	0.1	1.9	-0.6	-0.0	1.0	0.5	0.3	0.6
High blood pressure	0.7	2.0	6.9	-2.6	-1.6	-0.0	2.6	-0.2	1.2	0.1	-0.8	1.4	0.1
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.8	-0.5	-0.0	-1.6	-1.6	-1.2	-0.5	0.1	-1.1	-0.4	-1.7
Multivitamins +/- minerals	1.1	1.4	5.2	0.8	0.5	1.1	-1.1	0.2	1.0	1.3	2.3	-1.4	1.0
Stomach or abdominal pain in last month	0.7	0.9	2.4	-0.2	-1.6	0.3	1.2	-0.4	1.3	1.1	0.7	0.6	0.7
Supplements: Glucosamine	0.2	0.3	1.0	-0.2	-0.0	-0.7	0.4	-1.0	-0.2	0.6	-0.1	-0.9	-0.1
Diverticular disease/diverticulitis (self-reported)	2.2	2.6	5.6	-0.6	-0.9	2.1	1.7	2.2	1.2	0.3	2.3	-0.3	2.4
Medication: Atenolol	0.5	0.6	2.7	-0.3	0.1	-0.0	1.6	0.8	0.0	0.3	0.2	1.2	1.0
Medication: Levothyroxine sodium	0.4	0.7	2.1	0.6	-0.1	0.6	-1.4	0.7	1.0	1.2	0.8	-0.5	-0.3
Sitting height	1.1	8.0	16.9	-1.2	-1.7	1.6	3.4	2.8	3.8	2.9	2.4	4.1	2.8
Chronic bronchitis/emphysema (father)	0.6	0.7	1.9	1.3	0.2	1.4	-0.7	0.3	0.3	-0.5	1.1	-0.4	0.8
High blood pressure (mother)	2.3	3.2	7.3	-2.7	-1.2	-1.7	-0.5	-1.4	-1.6	-1.8	-2.3	-1.1	-2.5
Body mass index (BMI)	0.6	2.6	7.7	1.9	1.0	2.8	-1.0	1.4	1.7	1.1	1.9	-1.3	1.4
Impedance of leg (left)	2.1	10.3	23.8	-2.9	-0.9	-4.9	-1.7	-3.7	-2.9	-2.5	-4.5	-1.2	-4.1
Leg predicted mass (left)	1.8	9.4	16.6	1.1	-0.6	4.1	2.8	3.5	3.6	2.7	3.9	2.1	4.0
Trunk fat mass	0.2	0.9	2.2	-0.0	-0.8	1.5	1.1	0.5	1.5	0.7	0.9	-0.3	1.2
Waist circumference	0.5	1.7	3.7	0.2	-0.0	1.9	0.8	1.1	1.7	1.7	1.6	0.4	1.6
Number of incorrect matches in round	0.5	0.8	2.8	1.2	1.4	0.5	0.4	0.4	-0.8	-0.4	-0.2	1.7	0.1
Past tobacco smoking	1.9	3.5	11.6	-3.4	-2.9	-0.9	2.7	0.4	0.8	0.8	-1.0	2.1	-0.3
Alcohol usually taken with meals	0.5	0.8	3.2	-0.3	-0.5	-1.8	-0.8	-0.5	-0.5	0.1	-0.9	-1.2	-0.7
Nervous feelings	1.7	3.2	9.7	1.3	1.5	-0.9	-1.4	-1.1	-3.1	-2.7	-1.0	-1.9	-1.6
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	3.5	0.3	-0.3	1.8	0.6	0.6	-0.4	-0.5	1.9	-1.1	1.3
Hearing difficulty/problems with background noise	0.8	1.2	2.9	1.7	1.4	0.8	-1.5	0.8	0.4	0.9	1.5	0.9	-0.3
Hair/balding pattern: Pattern 2	0.9	1.1	6.0	-1.4	-1.2	-0.2	0.9	0.7	-0.7	0.7	0.3	2.4	0.0
Had menopause	0.7	0.8	2.5	-1.0	-1.6	-0.8	-0.1	-0.6	-0.3	-0.9	-1.0	-1.2	-0.6
Had other major operations	0.8	1.0	4.3	-0.4	-0.6	0.4	-0.8	0.6	1.8	2.1	0.9	-0.1	0.5
Forced vital capacity (FVC)	0.4	1.4	3.5	-1.7	-1.1	-1.1	-0.9	0.1	1.9	0.6	-1.0	1.4	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	5.9	1.2	1.1	-1.2	-1.1	-1.3	-2.4	-1.5	-1.4	-0.1	-1.6
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.5	0.4	1.3	0.3	-0.9	0.1	-1.6	-0.9	0.2	-1.1	0.2
Qualifications: None of the above	2.2	4.7	15.6	4.0	3.3	2.4	-0.6	2.1	-0.3	-0.4	1.9	-0.8	2.5
Financial difficulties in last 2 years	2.0	2.7	8.0	-0.2	0.4	1.8	0.7	1.2	2.8	2.5	2.0	-0.9	1.7
Mouth/teeth dental problems	0.5	0.8	2.3	-0.2	0.0	-0.6	-0.9	-1.4	0.4	1.0	-0.8	-0.7	-1.5
Heart attack	0.4	0.5	2.8	1.7	0.4	0.5	-0.7	-0.2	0.4	0.7	0.4	0.5	-0.3
Allergy	0.3	0.6	2.9	0.5	0.6	0.5	1.7	0.2	-0.1	0.3	0.6	-0.5	1.3
Pain all over the body in last month	0.8	0.9	3.1	0.5	-0.1	1.8	-0.6	-0.8	1.1	-0.3	1.4	-1.0	0.1
Diabetes (self-reported)	1.0	1.6	2.8	-1.6	-1.3	0.6	1.2	0.4	1.7	1.4	1.2	1.5	0.8
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	4.0	-0.0	-0.0	-1.2	-1.2	-1.5	-0.5	-1.2	-2.0	-0.6	-1.6
Medication: Ramipril	0.3	0.4	1.7	-0.1	0.1	0.2	1.3	0.3	-0.3	0.5	0.5	1.0	0.6
Medication: Simvastatin	0.3	0.4	2.3	0.2	0.2	0.2	-0.0	-0.3	1.5	0.7	-0.0	0.7	-0.5
Fluid intelligence score	0.8	1.8	4.5	-2.1	-0.3	-1.7	1.1	-1.9	0.3	-0.3	-1.7	0.3	-1.4
Illnesses of siblings	0.5	0.6	1.6	-1.3	-1.1	0.3	0.1	1.2	-0.1	0.5	0.9	0.8	0.7
Neuroticism score	0.4	0.8	1.9	0.7	1.1	0.7	-0.4	0.6	-1.1	-0.6	0.9	-1.4	0.8
Weight	1.2	5.8	11.8	0.8	-0.3	3.4	1.7	2.9	3.1	2.3	3.0	1.1	3.0
Impedance of arm (right)	1.8	8.2	22.4	-3.4	-1.6	-4.7	0.7	-3.7	-2.0	-1.1	-4.0	0.3	-3.2
Arm fat percentage (right)	0.1	0.5	1.4	0.4	0.2	1.1	-0.1	0.1	1.1	0.8	0.5	-1.2	0.6
Trunk fat-free mass	2.0	11.2	19.3	0.8	-0.4	4.3	3.4	4.4	3.4	2.3	4.3	2.6	4.4
Hip circumference	0.6	2.5	6.5	1.1	0.3	2.5	0.9	1.9	1.8	1.3	1.9	-0.0	2.1
Time employed in main current job	0.7	0.8	4.2	-0.9	-2.1	-0.4	0.5	-1.1	0.2	1.0	-0.4	0.5	0.4
Alcohol intake versus 10 years previously	1.4	2.0	4.6	1.6	1.0	1.6	-0.5	2.1	0.8	1.6	1.9	0.1	1.6
Father’s age at death	1.5	2.0	6.1	-1.2	-1.9	-0.5	2.0	-1.2	0.2	-2.5	-1.0	-1.4	0.7
Worrier / anxious feelings	0.9	1.7	4.0	-1.4	-0.5	-1.1	-0.2	-1.8	-1.5	-1.1	-1.2	-2.0	-1.1
Frequency of tiredness / lethargy in last 2 weeks	3.5	5.6	14.3	1.8	0.6	3.7	-0.2	2.4	2.1	1.7	3.8	0.6	3.4
Falls in the last year	1.4	1.8	5.5	1.1	0.4	1.7	0.0	0.9	1.7	1.0	2.3	-0.7	1.9
Hair/balding pattern: Pattern 3	0.2	0.3	1.7	-0.4	-0.6	0.4	0.3	0.1	0.7	-0.3	0.2	-1.3	0.2
Number of live births	0.3	0.4	2.2	-0.4	-1.5	0.5	0.3	0.1	1.2	0.2	0.1	0.3	-0.2
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	3.5	-1.9	-1.6	-1.2	-0.7	-0.2	1.6	0.5	-1.1	1.1	-1.5
Pulse rate	0.4	0.7	3.1	-0.8	-0.8	0.2	0.6	-1.3	0.7	0.0	-0.2	-1.8	-0.2
Happiness	0.9	1.1	4.4	-0.1	0.1	0.0	2.1	1.1	-1.5	-1.5	-0.2	-0.9	0.6
Noisy workplace	0.6	0.7	1.6	0.7	0.8	-0.1	0.1	0.9	-0.8	1.2	0.5	1.0	1.3
Qualifications: A levels/AS levels or equivalent	0.8	1.8	4.4	-2.1	-1.9	-1.3	1.1	-1.8	0.6	0.7	-1.3	0.1	-1.2
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	1.6	0.9	0.7	0.1	-0.3	-0.5	0.4	0.2	0.1	-1.3	0.2
Mouth/teeth dental problems: Dentures	1.4	2.4	5.2	2.3	2.0	2.0	1.0	1.1	-0.3	-0.2	1.7	-0.5	2.1
Asthma	0.4	0.8	5.2	-0.6	-0.6	0.3	-2.3	0.1	0.3	0.8	0.2	0.5	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	3.7	1.6	1.9	0.1	-1.7	0.5	-0.7	-0.6	0.8	-0.2	0.3
Medication: Cholesterol lowering	0.2	0.4	1.0	0.0	-0.2	-0.4	0.9	-0.7	0.8	1.0	-0.4	-0.3	-0.3
Depression (self-reported)	0.7	0.9	2.1	1.5	1.0	0.8	-1.2	0.4	0.1	-0.1	1.2	-1.2	0.3
Medication: Lansoprazole	0.3	0.4	1.5	0.2	0.7	-0.1	-1.2	-0.3	-0.3	1.1	-0.4	0.4	-0.4
Prospective memory result	1.4	1.7	5.9	2.4	1.7	0.6	-2.1	0.6	-1.3	-0.5	0.4	-1.2	0.1
Lung cancer (father)	0.8	0.9	2.0	0.8	0.6	0.4	-1.3	-1.4	-0.7	-1.1	-0.2	-1.1	-1.1
Illnesses of mother	0.4	0.5	1.7	1.1	0.9	-0.1	-1.3	-0.5	0.0	0.7	0.6	0.0	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	2.4	-1.4	-1.0	-1.3	0.1	0.0	1.3	1.1	-0.8	1.6	-1.0
Pulse wave Arterial Stiffness index	0.8	0.9	2.4	1.0	1.3	-0.1	-1.6	-0.6	-1.0	-1.2	-0.7	-0.4	-0.6
Impedance of arm (left)	2.7	12.6	31.9	-3.9	-2.2	-5.6	-0.2	-4.5	-2.4	-1.5	-5.1	-0.5	-4.3
Arm fat mass (right)	0.5	2.0	5.8	1.0	0.2	2.4	0.4	1.3	1.9	1.3	1.7	-0.4	1.6
Trunk predicted mass	1.9	10.8	18.7	0.7	-0.3	4.2	3.4	4.3	3.4	2.3	4.2	2.5	4.3
Standing height	1.2	11.9	34.9	-2.0	-2.5	1.8	5.9	3.5	3.0	2.2	2.6	5.0	3.6
Length of working week for main job	2.2	2.4	5.0	0.9	1.2	1.6	-0.7	2.2	0.5	1.8	1.8	2.1	1.5
Exposure to tobacco smoke at home	0.8	0.9	5.1	1.1	2.2	0.2	-1.3	0.1	-0.5	-0.0	0.1	-0.9	0.5
Breastfed as a baby	1.5	1.9	4.9	-0.6	-1.7	-2.0	0.3	-1.5	-0.0	-1.8	-2.2	0.3	-1.1
Tense / ‘highly strung’	0.9	1.4	3.0	1.5	1.7	1.6	-0.2	1.4	-0.1	0.0	1.6	-0.1	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	5.6	-0.9	0.1	-0.5	-0.6	-1.8	-0.2	-0.7	-0.7	-2.4	-0.7
Hair/balding pattern: Pattern 4	0.3	0.8	2.0	1.3	1.4	0.0	0.4	1.2	-1.1	0.2	0.2	-0.7	1.0
Birth weight of first child	0.4	0.7	1.9	-1.0	-0.2	-0.3	0.5	1.0	1.1	1.4	0.1	-0.1	1.1
Peak expiratory flow (PEF)	0.4	0.8	3.3	0.0	-0.8	-0.3	-1.0	-0.2	1.8	0.2	-0.3	0.3	-1.7
Pulse wave reflection index	1.7	2.1	8.3	1.9	1.8	-0.3	-2.9	-0.3	-0.9	-1.4	-0.9	-0.1	-1.4
Ever highly irritable/argumentative for 2 days	1.1	1.3	3.3	1.8	1.8	1.2	0.4	1.4	-0.3	0.2	1.3	-0.2	1.2
Loud music exposure frequency	0.6	0.6	1.9	-1.2	-0.6	-0.7	-1.4	-0.1	0.5	0.6	0.0	-1.3	-0.2
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	5.6	-2.4	-1.9	-0.9	0.7	-1.1	1.2	1.4	-0.7	2.0	-1.0
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.2	-1.1	-1.0	-0.5	0.1	0.5	-1.0	-0.7	-0.2	0.6	-0.2
Blood clot in the leg (DVT)	1.2	1.5	6.1	-1.6	-1.5	-0.5	0.2	-1.0	-0.5	-2.5	-1.4	0.3	-1.1
Medication: Paracetamol	1.0	1.6	5.2	1.8	1.3	0.1	-2.3	-0.6	-0.4	-1.0	-0.2	-2.0	-0.8
Headache pain in last month	0.5	0.9	2.5	-1.2	-1.2	-1.2	-1.6	-0.9	-0.2	0.8	-0.2	0.0	-0.5
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	7.9	1.4	1.1	0.9	-2.8	0.7	-1.1	-1.0	0.8	-0.3	-0.0
Glaucoma (self-reported)	0.4	0.5	1.1	-0.3	-0.8	0.5	1.0	0.6	0.8	0.4	0.6	1.0	0.7
Gout (self-reported)	0.2	0.3	1.2	0.0	-0.5	0.0	-0.6	0.0	0.5	0.6	-0.0	1.1	-0.6
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.2	-0.6	-1.0	-0.6	-0.7	0.2	0.5	1.1	0.2	-0.7	-0.1
Medication: Amlodipine	1.3	1.8	7.4	-2.0	-1.2	-0.1	2.7	0.4	-1.6	-1.2	-0.6	0.6	0.3
Medication: Ventolin 100micrograms inhaler	0.5	0.7	3.1	0.3	0.1	0.1	-1.7	0.2	0.0	0.6	0.2	-1.8	0.1
Birth weight	1.9	4.0	12.5	1.2	1.2	1.8	0.8	3.5	1.1	1.6	2.3	1.1	3.3
Chronic bronchitis/emphysema (mother)	1.6	1.8	3.4	0.2	0.8	1.7	-0.7	1.8	1.3	1.5	1.6	1.5	1.3
High blood pressure (siblings)	0.2	0.3	0.9	1.0	0.7	-0.4	-0.5	-0.6	-0.4	0.2	-0.8	-0.1	-0.4
Forced vital capacity (FVC), Best measure	0.3	1.0	3.3	-1.1	-0.4	-1.2	0.2	0.2	1.4	0.9	-0.8	1.8	-0.7
Body fat percentage	0.1	0.4	2.1	0.2	-0.2	0.3	-0.5	-0.9	0.5	0.1	-0.5	-1.5	-0.4
Leg fat percentage (right)	0.2	0.9	4.5	0.4	0.3	-0.1	-1.2	-0.9	0.2	-0.2	-0.9	-2.1	-1.0
Arm fat-free mass (right)	1.8	9.1	20.0	1.5	-0.3	4.5	2.2	4.1	3.0	1.9	4.1	1.5	3.9
Exposure to tobacco smoke outside home	2.3	3.1	6.5	2.0	2.5	2.4	-0.8	1.9	1.1	-0.3	2.5	0.3	1.8
Comparative body size at age 10	0.4	1.1	3.5	-1.3	-1.9	-0.2	0.8	-1.1	0.6	-0.2	-0.8	-1.5	-0.5
Number of full brothers	0.4	0.5	1.7	-0.2	-1.3	0.4	0.1	0.2	0.5	1.0	1.0	-0.4	0.6
Worry too long after embarrassment	0.3	0.5	1.9	-0.1	0.7	-0.7	-0.7	-1.4	-1.0	-0.2	-0.5	-0.4	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	3.1	-1.4	-1.8	-0.1	0.6	-1.1	0.5	0.0	0.1	-0.6	-0.1
Wheeze or whistling in the chest in last year	3.0	5.3	12.3	0.9	0.6	3.5	-1.3	3.1	2.2	2.2	3.1	2.3	2.0
Number of children fathered	0.4	0.5	1.7	1.3	1.1	0.3	-0.8	0.4	0.2	0.4	0.6	0.1	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.3	5.3	-2.0	-2.3	-1.4	0.6	-1.6	0.5	-0.8	-2.1	-0.4	-1.9
Age at first live birth	0.7	1.3	2.6	-1.6	-1.0	-1.6	0.5	-1.1	-0.1	-0.7	-1.0	1.6	-1.0
Pulse wave peak to peak time	0.9	1.1	3.0	-1.1	-1.3	0.2	1.7	0.8	1.0	1.4	0.8	0.6	0.7
Health satisfaction	1.5	1.9	5.1	1.4	0.4	2.1	1.1	2.3	-0.3	0.3	1.8	0.3	1.8
Shortness of breath walking on level ground	0.3	0.3	0.7	0.7	0.7	0.8	-0.5	0.5	-0.8	-0.2	0.6	0.2	0.3
Qualifications: College or University degree	0.8	2.5	7.8	-2.8	-2.3	-1.1	2.5	-1.1	1.0	-0.3	-0.9	-0.4	-0.6
Eye problems/disorders: None of the above	1.0	1.1	3.2	1.0	1.8	0.0	-1.3	0.0	-0.4	-1.5	-0.0	-1.7	-0.7
Mouth/teeth dental problems: Loose teeth	0.2	0.2	1.1	0.7	1.0	-0.3	-0.4	0.0	-0.3	0.2	0.2	0.0	-0.3
Emphysema/chronic bronchitis	1.2	1.4	3.6	-0.4	-1.5	1.1	0.8	0.7	1.9	0.8	1.3	1.6	0.8
Medication for pain relief, constipation, heartburn	0.9	1.6	5.8	-2.4	-1.3	-1.0	1.9	-0.5	0.7	0.9	-1.2	0.9	-0.4
Neck or shoulder pain in last month	0.0	0.1	0.2	0.4	-0.0	-0.3	-0.1	0.4	0.3	-0.2	0.1	0.0	0.4
Medication: Blood pressure	0.9	1.7	11.3	-0.9	-0.8	0.4	3.4	0.4	0.8	0.6	-0.0	1.3	1.0
Angina (self-reported)	0.2	0.3	1.0	1.0	0.5	0.8	0.5	-0.0	0.5	-0.2	0.2	-0.5	0.4
Migraine (self-reported)	0.3	0.4	1.6	-1.1	-1.3	0.0	0.3	-0.3	0.7	-0.3	-0.6	-0.3	-0.1
Medication: Ibuprofen	1.1	1.3	4.9	1.7	2.2	0.2	-1.9	0.7	-0.3	-0.5	0.9	0.3	0.1
Medication: Allopurinol	0.1	0.2	0.4	-0.1	-0.1	-0.5	-0.3	-0.1	-0.2	0.6	-0.4	0.5	-0.6
Medication: Omeprazole	0.8	0.9	2.4	-0.5	-1.5	-0.9	0.7	-0.6	-1.2	-1.6	-0.6	-0.9	-0.2
Medication: Seretide 50 evohaler	0.4	0.5	1.4	0.7	-0.3	0.3	-1.2	-0.2	1.1	0.1	-0.2	-0.7	-0.7
Mean time to correctly identify matches	0.4	0.8	2.3	0.8	0.9	-0.0	0.1	-0.8	-1.5	-1.5	-0.2	-1.3	-0.4
Heart disease (mother)	0.8	0.9	1.9	0.6	-0.5	1.3	1.4	1.2	0.8	0.2	0.5	1.3	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.9	0.1	-0.1	-0.9	-0.7	-0.6	-0.1	-0.1	-0.9	-1.4	-0.9
Whole body fat mass	0.2	0.9	2.3	0.4	-0.3	1.5	0.6	0.5	1.4	0.9	0.9	-0.7	1.1
Leg fat mass (right)	0.2	0.9	2.4	1.0	0.2	1.6	0.0	0.6	1.4	0.9	0.9	-1.1	0.8
Arm predicted mass (right)	1.7	8.5	17.7	1.4	-0.4	4.2	2.1	4.0	3.0	1.9	3.9	1.9	3.7
Pulse rate, automated reading	0.7	2.1	9.3	-2.7	-3.0	-0.4	1.2	-1.2	0.9	0.3	-0.8	0.6	-0.1
Alcohol intake frequency.	0.6	1.5	3.0	1.7	1.0	1.4	-0.5	1.1	0.4	1.5	1.6	-0.1	1.6
Comparative height size at age 10	1.3	6.9	21.9	-2.8	-2.9	0.4	4.7	2.4	1.7	1.4	1.1	4.0	1.8
Number of full sisters	1.2	1.5	3.7	1.5	1.2	1.2	-1.9	0.7	1.0	1.5	1.3	-0.5	0.9
Suffer from ‘nerves’	0.6	0.9	4.0	0.7	2.0	0.3	-1.4	0.3	-0.9	0.6	0.6	-1.1	-0.0
Overall health rating	1.2	2.6	8.1	1.4	0.5	2.8	0.5	1.1	1.6	0.5	2.3	-0.2	2.4
Chest pain or discomfort	0.8	1.2	3.2	1.2	1.8	1.0	-1.2	1.4	0.2	0.9	0.9	-0.2	0.9
Had major operations	1.0	1.1	3.7	-1.5	-1.9	-1.5	0.7	0.4	0.1	0.6	-0.8	1.2	0.2
Age at last live birth	1.3	1.9	5.0	-1.5	-0.9	-2.2	0.4	-2.2	-0.3	-0.3	-1.7	0.6	-1.5
Family relationship satisfaction	0.3	0.4	1.1	0.8	0.1	0.7	0.2	1.0	-0.5	0.7	0.5	-0.5	0.3
Leg pain on walking	0.2	0.3	0.5	0.5	-0.3	0.7	0.1	0.2	0.4	-0.7	0.6	-0.7	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	2.0	-0.6	-0.9	1.0	-0.2	-0.0	0.9	1.4	1.3	1.2	0.9
Commuting to job workplace: Car/motor vehicle	1.8	2.1	5.6	2.3	1.5	2.4	-0.7	0.9	0.1	-1.2	1.6	0.8	1.4
Illness, injury, bereavement, stress in last 2 years	0.9	1.0	2.1	-1.4	-1.1	-1.1	1.4	-0.1	-0.4	-0.5	-1.4	1.3	-0.2
Medication: Aspirin	0.4	0.6	1.2	0.5	0.3	0.7	-0.3	1.1	0.2	1.1	1.0	1.1	0.5
Supplements: Vitamin C	0.7	0.8	2.2	1.5	1.2	-0.1	-0.7	-0.7	-0.8	-1.1	-0.6	-0.6	-1.1
Knee pain experienced in last month	0.4	0.6	2.7	0.3	0.2	0.3	0.1	0.6	-1.3	-0.4	0.5	-1.0	1.6
Hypertension (Self-reported)	0.8	2.1	7.6	-2.6	-1.9	0.3	2.8	-0.1	1.5	0.1	-0.5	1.0	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	2.2	1.0	0.6	-0.5	-0.4	-0.4	-1.5	-1.1	-0.4	0.3	-0.8
Illnesses of father: Heart disease	0.6	0.8	3.6	-0.3	-1.3	0.1	-0.5	0.2	-0.0	1.4	0.4	-1.9	-0.4
Illnesses of siblings: Diabetes	0.4	0.5	3.2	-0.3	-0.1	-0.7	1.8	-1.0	0.4	0.4	-0.0	0.2	-0.1
Smoking status: Previous	2.1	3.2	10.5	3.2	2.7	0.8	-2.8	-0.3	-0.4	-0.7	1.0	-2.0	0.4
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.7	8.3	0.9	0.5	2.8	2.5	1.9	0.9	0.2	2.5	1.6	2.9
Whole body fat-free mass	2.1	11.8	21.4	1.2	-0.3	4.6	3.2	4.4	3.5	2.5	4.5	2.5	4.5
Leg fat-free mass (right)	1.8	9.7	17.6	1.1	-0.5	4.2	2.7	3.6	3.5	2.5	4.0	2.4	4.1
Arm fat percentage (left)	0.1	0.5	2.8	0.3	-0.0	0.6	-0.7	-0.6	0.7	0.4	-0.3	-1.7	-0.2
Average weekly red wine intake	0.5	0.7	3.6	-1.4	-1.9	-0.1	0.1	0.2	1.0	-0.3	0.0	-0.8	0.2
Handedness (chirality/laterality): Left-handed	2.0	2.4	6.5	-0.6	-0.1	-2.3	0.4	-1.6	-1.4	-1.4	-2.6	-1.6	-1.5
Mood swings	1.9	3.4	8.5	1.8	0.8	2.7	-0.3	2.4	0.6	1.5	2.9	0.3	2.4
Loneliness, isolation	1.7	2.3	6.4	-0.0	-0.2	1.9	0.9	2.4	0.7	1.6	2.5	0.6	1.8
Long-standing illness, disability or infirmity	0.9	1.3	4.5	1.4	0.2	2.1	-0.6	0.1	0.5	-0.8	1.7	0.9	1.2
Ever had bowel cancer screening	2.0	2.4	5.9	-0.2	-0.6	-1.3	-1.6	-2.4	-0.2	-2.4	-2.1	-0.8	-1.6
Diabetes diagnosed by doctor	0.8	1.4	3.1	-1.7	-1.6	0.8	0.9	0.3	1.4	1.2	1.3	0.9	0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	6.7	2.1	2.2	0.2	-2.6	0.1	-0.3	0.5	0.5	-1.6	-0.4
Friendships satisfaction	0.2	0.3	0.7	-0.8	-0.7	0.1	0.8	0.2	-0.0	0.0	-0.4	-0.7	-0.4
Qualifications: nursing, teaching	1.0	1.5	3.3	-1.3	-1.1	-1.0	1.1	-1.8	0.3	-0.7	-1.7	0.1	-1.6
Commuting to job workplace: Walk	0.5	0.5	1.9	0.4	0.3	-0.3	-0.9	-0.4	-0.2	-0.5	-0.8	-1.4	-1.0
Eye problems/disorders: Cataract	0.6	0.7	2.3	-0.6	-1.5	0.3	1.2	1.0	0.2	-0.3	0.0	1.3	0.4
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	4.3	-1.8	-2.1	-1.7	0.5	-0.8	0.6	-1.0	-1.4	0.7	-0.9
Medication for cholesterol	0.2	0.3	0.8	0.7	0.6	0.5	-0.3	0.9	0.3	-0.8	-0.0	-0.5	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	4.0	0.7	-0.3	1.2	-0.9	-1.7	1.3	-0.9	0.6	-2.0	-0.1
Back pain experienced in last month	0.6	0.9	2.2	1.4	1.5	-0.6	-1.2	-0.9	-0.3	0.3	-0.5	-1.0	-0.7
Mineral and other dietary supplements	0.3	0.4	1.8	0.2	0.4	0.0	-1.3	0.7	0.1	-0.4	-0.5	0.8	-0.7
Breast cancer (self-reported)	0.4	0.5	1.7	1.3	0.5	0.9	0.7	0.8	0.3	-1.0	-0.1	0.1	0.0
Asthma (self-reported)	0.5	1.1	6.7	-0.6	-0.5	0.0	-2.6	-0.1	0.5	1.2	0.0	0.5	-1.2
Osteoporosis (self-reported)	0.4	0.5	1.4	-0.7	-0.5	0.0	0.4	0.8	0.9	1.0	0.2	1.2	0.5
Osteoarthritis (self-reported)	1.0	1.3	3.0	1.6	1.0	1.1	0.1	1.2	-1.2	-1.7	0.7	-0.9	0.6
Medication: Aspirin	0.8	1.1	2.4	0.6	0.5	1.1	-0.5	1.6	0.5	1.4	1.3	1.4	0.8
Medication: Gliclazide	1.4	1.5	5.2	-2.3	-2.2	-0.5	1.0	-0.8	1.5	0.2	-0.2	1.1	-0.3
Illnesses of father: None of the above (group 1)	1.1	1.4	3.4	0.2	1.1	-1.7	-0.4	-1.8	-0.2	-0.7	-1.9	0.5	-1.5
Smoking status: Current	0.8	1.3	4.5	0.4	0.0	2.1	0.5	0.6	1.6	0.9	1.4	0.5	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.7	0.5	0.2	0.0	-0.8	-0.2	0.4	-0.8	-0.1	-0.5	0.1
Whole body water mass	2.2	12.5	22.8	1.3	-0.3	4.8	3.2	4.5	3.7	2.6	4.7	2.6	4.6
Leg predicted mass (right)	1.8	9.9	17.8	1.1	-0.5	4.2	2.8	3.7	3.5	2.5	4.1	2.5	4.1
Arm fat mass (left)	0.3	1.1	3.3	0.6	-0.1	1.8	0.2	0.7	1.6	1.0	1.1	-0.8	1.0
Number of self-reported non-cancer illnesses	0.3	0.5	1.5	-0.0	-0.6	1.1	0.5	-0.6	1.0	-1.2	0.1	0.9	0.0
Average weekly champagne plus white wine intake	0.6	0.8	3.3	1.1	1.5	-0.1	-0.5	-0.7	-0.9	-0.3	-0.3	-1.8	-0.2
Miserableness	0.3	0.6	2.6	0.3	0.2	0.7	-1.2	0.4	0.5	0.4	0.7	-1.6	0.1
Guilty feelings	0.8	1.2	2.9	0.5	1.4	-1.3	-1.4	-0.6	-1.4	0.6	-0.2	-1.7	-0.4
Wears glasses or contact lenses	0.7	0.8	1.8	-1.4	-1.0	-1.1	1.2	-0.6	-0.8	0.0	-0.9	-1.0	0.2
Ever taken oral contraceptive pill	0.6	0.7	1.8	-1.3	-0.4	-1.3	-0.8	-0.7	-0.1	-0.1	-1.0	-0.7	-0.7
Hearing aid user	0.6	0.6	1.8	1.1	1.3	0.1	-1.0	-0.5	-0.4	-0.0	-0.3	-0.4	-1.3
Mother’s age at death	2.3	2.9	8.1	-1.9	-2.1	-1.4	0.4	-1.4	-0.7	-2.0	-1.7	-2.8	-1.2
Financial situation satisfaction	1.3	1.6	3.3	1.8	1.6	1.6	0.7	0.7	0.1	0.8	1.7	-0.2	1.6
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.0	0.1	0.6	-0.2	0.0	1.0	-0.9	-0.8	-0.4	0.6	0.5
Commuting to job workplace: Public transport	0.7	0.8	2.7	-0.5	-0.1	-1.5	-0.5	-1.0	0.4	-0.0	-1.7	-0.7	-1.1
Eye problems/disorders: Glaucoma	0.2	0.2	0.6	-0.2	-0.8	-0.5	0.4	-0.5	-0.2	0.2	-0.6	-0.1	-0.2
Medication: Blood pressure	0.4	0.7	1.8	-0.8	-0.3	-1.2	-0.2	-1.0	-0.9	-0.5	-1.3	-0.2	-0.9
Pain type(s) experienced in last month: Hip pain	1.0	1.3	4.1	1.6	1.0	1.5	-2.0	1.1	0.5	0.1	1.2	-0.2	0.3
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.9	-0.2	-0.1	-0.3	-0.2	-1.2	-0.5	-0.9	-0.3	-1.4	-0.5
High cholesterol (Self-reported)	0.5	0.9	2.2	-0.3	-0.1	-1.3	-0.7	-1.5	0.1	-0.1	-1.5	-0.3	-1.4
Medication: Bendroflumethiazide	1.0	1.5	6.4	-2.5	-1.9	-0.5	1.9	-0.4	0.3	-0.1	-0.7	-0.1	0.0
Medication: Paracetamol	0.9	1.5	4.9	1.1	0.8	-0.5	-2.2	-0.7	-0.6	-1.2	-0.7	-1.7	-1.4
Medication: Lisinopril	0.6	0.8	3.2	-0.1	-0.0	0.4	1.3	0.1	0.8	1.0	0.3	1.8	0.9
Medication: Atorvastatin	0.8	0.9	2.7	-0.8	-0.5	-1.3	-0.2	-1.1	-0.4	0.0	-1.4	-1.6	-1.0
Illnesses of father: High blood pressure	1.0	1.2	2.8	-1.7	-1.7	0.4	0.9	0.0	1.2	0.9	0.8	1.5	0.8
Alcohol drinker status: Never	0.2	0.2	0.9	-0.3	-0.9	-0.2	0.3	-0.2	0.7	0.7	-0.2	-0.4	-0.4
Ever smoked	0.9	1.5	6.0	2.4	1.9	0.8	-1.2	-0.5	-0.3	-1.0	0.8	-1.1	0.3
Basal metabolic rate	1.8	9.9	18.2	1.1	-0.4	4.3	2.7	3.9	3.5	2.5	4.1	2.2	4.1
Leg fat percentage (left)	0.3	0.9	4.3	0.8	0.7	0.3	-1.5	-0.7	0.2	-0.3	-0.5	-2.1	-0.7
Arm fat-free mass (left)	2.0	10.1	19.6	1.2	-0.3	4.4	2.6	4.3	3.3	2.2	4.1	2.3	4.0
Number of operations (self-reported)	1.1	1.6	4.6	-0.1	-0.1	-2.1	-1.5	-1.8	-0.9	-0.2	-2.0	-0.5	-1.3
Average weekly beer plus cider intake	0.2	0.3	1.2	0.5	1.1	-0.8	0.0	-0.4	-0.0	0.8	0.3	0.3	-0.4
Irritability	1.7	2.9	7.0	-0.2	-0.4	2.6	2.1	1.8	1.9	0.2	2.1	1.5	2.0
Risk taking	0.4	0.6	1.7	0.7	0.7	1.3	-0.0	1.0	0.1	0.2	1.2	0.3	0.7
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.1	-1.4	-1.1	0.1	0.6	-0.5	1.4	1.3	-0.0	-0.3	0.3
Fractured/broken bones in last 5 years	0.7	0.9	2.0	0.5	0.2	1.4	-0.2	0.9	1.1	-0.2	1.4	-1.2	1.2
Age started oral contraceptive pill	0.9	1.1	2.5	-1.5	-1.6	-1.4	1.1	-0.9	0.9	-0.5	-1.1	0.1	-0.7
Diastolic blood pressure, automated reading	1.1	3.4	7.6	-0.3	-1.1	2.4	1.4	1.8	2.3	1.7	1.9	2.8	1.6
Ever depressed for a whole week	0.2	0.3	0.9	0.3	1.0	-0.1	-0.9	-0.3	-0.3	-0.3	-0.1	-0.7	-0.3
Unable to work because of sickness or disability	1.8	2.3	6.6	1.6	0.7	2.6	-1.2	1.0	1.7	0.3	2.0	-1.1	1.6
Commuting to job workplace: Cycle	0.3	0.3	1.2	-1.1	-0.5	0.2	-0.8	0.6	0.2	0.5	0.5	-0.5	-0.4
Myopia	0.3	0.5	1.3	0.5	1.2	-0.1	-1.1	-0.4	-0.2	-0.5	-0.1	-1.1	-0.0
Vascular/heart problems diagnosed by doctor	0.5	1.4	7.4	1.7	1.2	-0.4	-2.7	0.0	-1.0	0.2	0.5	-1.1	-0.3
Cholesterol lowering medication	0.6	0.9	1.7	-1.3	-1.1	-0.6	-0.3	-0.7	1.1	1.3	-0.4	0.8	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	4.6	-0.7	-2.1	-0.9	0.2	-1.1	-0.6	-1.5	-0.7	-0.9	-0.3
Pain experienced in last month	0.4	0.6	2.3	-1.0	-0.4	-0.6	1.5	0.6	0.2	0.2	-0.5	1.1	-0.5
Supplements: Calcium	0.8	0.9	2.5	-1.6	-1.0	-1.4	0.4	-0.5	1.0	1.1	-0.8	0.4	-0.4
Basal cell carcinoma (self-reported)	0.3	0.4	1.4	0.5	0.4	-1.2	-0.3	-0.4	-0.3	-0.6	-0.9	-0.3	-0.7
Heart attack/myocardial infarction (self-reported)	0.4	0.5	2.7	1.6	0.4	0.6	-0.9	-0.2	0.6	0.7	0.5	0.4	-0.3
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	7.7	-1.5	-1.5	-0.5	-0.2	-1.1	-0.4	-2.8	-1.4	-0.1	-1.2
Heart disease (siblings)	0.6	0.7	2.1	1.3	1.2	0.3	-1.4	0.1	0.3	0.3	0.3	-1.3	0.0
Alcohol drinker status: Previous	0.8	0.9	4.8	0.0	-0.6	0.8	-0.6	0.0	-1.0	-2.2	0.0	-1.1	0.8
Pack years of smoking	1.4	2.0	4.9	0.9	0.6	2.2	1.3	2.1	0.2	-0.5	2.1	0.8	1.7
Impedance of whole body	2.3	11.8	29.9	-3.3	-1.6	-5.5	-1.0	-4.2	-2.7	-2.0	-5.0	-0.8	-4.4
Leg fat mass (left)	0.3	1.1	3.0	1.1	0.4	1.7	-0.2	0.9	1.4	0.9	1.1	-1.0	0.9
Arm predicted mass (left)	2.2	11.1	22.4	1.4	-0.2	4.6	2.6	4.7	3.4	2.2	4.3	2.2	4.2