Hub : Genes

ACACB

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.0800	0.0370	6.1e-03	0.040	NA	0.004	NA	0.028	5.6e-04	NA	1.5e-01	NA	3.3e-03
2	GTEx	Testis	0.2210	0.0750	4.6e-03	0.264	NA	0.162	NA	0.251	4.3e-12	NA	1.1e-07	NA	1.7e-11
3	GTEx	Thyroid	0.1590	0.0410	8.6e-06	0.121	NA	0.065	NA	0.107	1.6e-09	NA	1.0e-05	NA	1.5e-08
4	YFS	Blood	0.1725	0.0251	0.0e+00	0.131	0.182	0.192	0.188	0.195	1.6e-40	3.1e-57	1.9e-60	2.5e-59	9.3e-62
5	TCGA	Bladder Urothelial Carcinoma	0.0530	0.0280	6.1e-03	0.013	0.019	0.007	NA	0.012	2.5e-02	9.2e-03	7.3e-02	NA	2.9e-02
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.0472	0.0177	4.1e-05	0.056	0.039	0.062	NA	0.066	6.4e-07	2.8e-05	1.6e-07	NA	6.7e-08
7	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0880	0.0390	4.8e-03	-0.001	0.021	-0.004	NA	-0.004	3.9e-01	2.2e-02	7.0e-01	NA	6.8e-01
8	TCGA	Brain Lower Grade Glioma	0.0698	0.0244	1.3e-06	0.024	0.050	0.043	NA	0.037	8.0e-04	2.1e-06	1.1e-05	NA	4.8e-05
9	TCGA	Lung Adenocarcinoma	0.0591	0.0244	2.5e-04	0.000	0.006	0.005	NA	-0.001	3.2e-01	5.6e-02	6.9e-02	NA	5.0e-01
10	TCGA	Lung Squamous Cell Carcinoma	0.0539	0.0195	6.6e-06	0.068	0.044	0.058	NA	0.064	3.9e-08	8.1e-06	3.9e-07	NA	8.7e-08
11	TCGA	Prostate Adenocarcinoma	0.0435	0.0192	1.1e-03	0.007	0.013	-0.001	NA	0.003	6.0e-02	1.3e-02	4.5e-01	NA	1.5e-01
12	TCGA	Stomach Adenocarcinoma	0.0510	0.0270	7.7e-03	0.035	0.027	0.014	NA	0.026	1.4e-03	4.2e-03	3.1e-02	NA	5.2e-03
13	TCGA	Thyroid Carcinoma	0.1620	0.0490	1.8e-10	0.097	0.119	0.123	NA	0.121	9.9e-10	1.3e-11	5.3e-12	NA	8.7e-12

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	0.4	0.6	1.4	0.8	-1.0	-0.2	0.5	0.7	0.3	1.0	1.2	-0.8	0.5	-0.2	0.9	1.0
Bipolar Disorder or Schizophrenia	0.8	2.0	5.3	-1.2	-1.3	-2.3	-0.9	-0.3	-1.7	-1.5	-0.4	-2.1	-1.6	-1.0	-1.7	-0.6
Depressed Affect (Nagel 2018)	0.4	0.8	2.7	0.1	1.0	1.3	-0.2	-0.6	1.2	1.0	-0.9	0.2	0.2	1.3	0.6	1.6
Depression (Nagel 2018)	0.2	0.4	1.4	-0.4	-0.9	-1.2	-0.5	-0.4	-0.6	0.1	-0.5	-0.8	-0.3	-0.5	-0.7	-0.2
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.7	-0.3	-0.0	-0.4	-0.8	-0.4	-0.5	-0.2	-0.6	-0.8	-0.1	0.2	-0.4	-0.8
Neuroticism (Nagel 2018)	0.5	1.1	5.0	-0.9	1.0	-0.2	-1.5	-1.9	-0.3	-0.0	-2.2	-0.7	-0.7	0.4	-0.7	0.4
Schizophrenia (2018)	2.1	4.3	8.5	-2.2	-1.0	-2.8	-1.6	-0.9	-2.4	-2.8	-1.5	-2.1	-2.5	-1.2	-2.9	-1.6
Schizophrenia vs Biploar Disorder	1.7	2.2	5.4	-1.5	0.8	-1.1	-2.0	-2.3	-1.4	-1.2	-2.1	-1.4	-1.3	-0.1	-1.7	-0.9
Worry (Nagel 2018)	0.3	0.7	2.4	-0.8	0.7	-0.3	-1.1	-1.6	-0.4	0.1	-1.5	-0.7	-0.6	-0.2	-0.6	0.2
Alzheimer’s Disease (in mother)	2.0	2.4	4.9	-1.3	0.9	-1.1	-2.1	-1.6	-1.8	-1.1	-2.2	-1.7	-1.1	-1.7	-1.3	-1.4
Alzheimer’s Disease (in father)	1.4	1.6	8.3	0.2	-0.1	0.4	2.0	2.9	1.0	-1.4	1.8	0.8	-0.3	-0.4	-0.3	0.8
Alzheimer’s Disease (including proxy)	0.2	0.2	0.8	0.1	0.5	0.3	0.4	0.9	0.1	-0.8	0.0	0.4	-0.0	-0.9	-0.3	0.1
Crohns Disease (2017)	0.8	1.7	4.4	1.1	0.1	1.1	1.6	0.1	1.2	1.8	1.1	1.3	0.9	1.2	1.9	2.1
Irritable Bowel Disease (IBD)	0.2	0.5	1.5	0.1	0.4	0.2	0.5	-0.8	0.3	1.2	0.8	0.6	0.0	0.4	1.1	1.0
Ulcerative Colitis (UC)	0.2	0.3	1.6	-0.6	0.6	-0.3	-0.6	-1.3	-0.4	0.6	0.1	-0.1	-0.6	-0.2	0.3	-0.1
Major Depression (MDD)	1.2	1.5	12.1	0.7	0.2	0.1	0.7	-1.3	0.2	3.5	0.5	1.1	0.8	-0.4	1.3	0.4
Reaction Time	0.1	0.2	0.6	0.4	-0.0	0.0	0.7	0.2	0.1	0.8	0.4	0.5	0.3	-0.0	0.3	0.6
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.8	0.1	-0.5	0.4	-0.6	-0.0	0.2	-0.1	-0.0	-0.9	0.2	0.3	-0.2	0.2
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.2	0.3	0.8	0.7	0.2	0.7	-0.4	-0.7	0.7	0.3	-0.6	-0.2	0.9	0.9	0.1	0.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.2	0.3	1.0	-0.3	0.9	-0.3	0.1	-0.1	-0.2	-0.3	-0.7	1.0	-0.3	0.3	-0.6	-0.5
Bipolar Disorder (2011)	0.5	0.5	1.3	0.8	0.0	-0.1	0.7	0.7	0.7	1.1	1.1	-0.2	0.6	-0.3	1.0	0.6
Body Mass Index (BMI) (2010)	0.2	0.3	1.7	-0.3	1.3	-0.4	-0.6	-0.5	-0.7	-0.3	-0.6	-0.5	-0.3	0.3	-0.2	-0.1
Coronary Artery Disease (CAD)	0.2	0.2	1.3	0.4	-0.3	0.2	-0.1	0.1	0.0	-0.5	-0.7	1.1	0.5	0.7	0.3	0.0
Crohns Disease (2012)	0.4	0.7	2.9	0.5	-0.4	0.6	0.8	0.1	0.8	0.5	0.7	0.4	0.4	1.2	1.2	1.7
Mean Putamen Volume	0.5	0.6	2.6	0.0	-1.6	0.1	0.8	1.2	0.3	-0.4	1.0	0.7	0.0	0.5	-0.8	0.3
Fasting Glucose	0.3	0.4	1.5	-0.3	-1.2	-0.7	0.4	0.7	-0.4	-0.1	0.6	-0.8	-0.5	-0.5	0.4	-0.2
HbA1C	1.1	1.2	2.5	-1.5	0.6	-1.1	-1.2	-1.6	-1.0	-0.8	-1.2	-0.8	-1.6	-0.9	-1.2	-0.5
HDL Cholesterol	0.4	0.6	2.0	0.6	-1.3	0.0	-0.2	-1.4	0.2	1.4	-0.2	-0.1	0.5	0.8	0.8	0.8
LDL Cholesterol	0.9	1.4	3.1	-1.4	0.8	-1.4	-1.2	-0.6	-1.2	-1.8	-1.3	-0.5	-1.7	-0.8	-1.1	-0.6
Lupus	1.5	2.3	4.6	-1.3	0.9	-1.5	-1.8	-2.1	-1.6	-0.5	-1.6	-1.9	-1.2	-1.6	-1.6	-1.2
Neuroticism (2016)	0.2	0.3	1.1	-0.0	1.0	-0.3	-0.4	-0.7	-0.2	0.2	-1.0	-0.8	-0.1	0.0	-0.1	0.5
Primary Biliary Cirrhosis	0.3	0.4	2.0	0.3	-1.1	0.3	0.9	0.3	0.0	0.2	0.8	1.4	0.2	0.3	0.2	-0.2
Rheumatoid Arthritis	0.4	0.6	1.5	-0.7	0.7	-0.5	-0.9	-1.2	-0.7	-0.4	-1.2	0.7	-0.5	0.1	-0.8	-0.9
Schizophrenia (2014)	1.9	4.2	7.9	-2.2	-1.2	-2.7	-1.7	-1.3	-2.5	-2.4	-1.5	-2.0	-2.4	-1.6	-2.8	-1.5
Triglycerides	0.4	0.7	5.4	-0.8	2.3	-0.6	-0.6	-0.7	-0.2	-0.3	-0.9	-0.2	-0.8	0.3	-0.6	0.2
Type 2 Diabetes (T2D) (2012)	5.5	6.3	13.0	2.6	1.0	3.3	2.0	1.6	3.6	3.2	1.9	1.5	2.6	1.7	2.7	3.3
Ulcerative Colitis	0.4	0.6	1.7	-1.0	-0.2	-0.9	-0.5	-1.3	-0.8	0.2	0.3	-0.1	-1.1	-0.9	-0.2	-0.7
Blood Eosinophil Count	0.7	5.7	20.0	3.0	1.5	1.5	1.2	0.4	2.4	2.2	1.9	-0.7	2.7	4.5	2.9	3.1
Blood Platelet Count	1.2	13.9	59.1	2.6	2.1	4.2	0.9	-4.4	3.6	5.2	1.9	7.7	3.4	2.4	2.7	2.1
Blood Red Count	0.1	1.0	2.5	0.4	1.6	0.6	-0.6	-1.4	0.9	1.3	-0.5	0.4	0.6	1.0	1.0	1.5
Blood White Count	0.4	2.9	7.6	-2.1	1.9	-2.8	-0.9	-1.4	-1.5	-1.6	-1.0	-1.4	-2.8	-1.6	-0.1	-0.8
Heel T-Score	0.7	5.7	13.2	3.2	1.1	3.3	1.3	0.3	2.5	2.2	0.1	2.4	3.6	3.1	2.3	2.4
BMI	0.1	0.6	2.4	-0.3	1.6	-1.5	-0.2	-0.7	-0.3	-0.3	-1.0	-0.7	-0.5	0.0	0.3	-0.0
Height	0.8	15.8	26.8	5.0	-2.8	5.1	3.7	3.4	3.7	2.7	3.6	4.2	5.2	5.0	3.4	2.7
Waist Hip Ratio (WHR)	0.3	1.2	4.2	-1.1	0.3	-1.8	-0.8	-0.4	-1.2	-0.3	0.3	-2.1	-1.4	-1.1	-0.4	-0.8
Systolic Blood Pressure	0.7	3.4	7.8	2.0	0.5	2.2	1.3	0.8	1.9	1.7	1.9	1.2	1.9	2.5	1.8	2.8
Smoking Status	0.1	0.3	1.1	-1.0	0.2	-0.0	-0.4	-0.3	-0.1	-0.6	-0.3	-0.1	-1.0	-0.7	0.3	-0.6
Allergy or Eczema	0.6	1.5	4.7	-0.9	0.1	-0.9	-2.1	-2.2	-0.7	0.2	-1.8	-2.0	-0.8	-0.2	-0.2	0.0
Cardiovascular Disease	2.1	6.8	12.9	2.7	0.9	2.8	2.3	1.4	2.9	2.2	1.6	2.7	2.6	3.6	3.6	3.1
Hypothyroidism (self reported)	0.8	1.8	4.4	-1.5	-0.2	-2.0	-1.1	-0.8	-1.5	-2.1	-0.8	-1.7	-1.7	-0.3	-1.0	-0.9
Respiratory disease	0.7	1.6	5.1	1.1	0.5	1.7	0.8	-0.1	1.6	2.2	0.7	1.1	1.2	0.4	1.6	1.4
Type 2 Diabetes (T2D) (2018)	0.3	0.5	2.4	-0.1	-0.9	-1.1	-0.4	-0.2	-0.6	-0.0	0.6	-1.6	-0.6	-0.1	0.7	0.2
Lung FEV1/FVC ratio	0.8	4.0	6.8	-1.9	1.2	-2.2	-2.5	-2.1	-2.4	-2.5	-2.4	-2.6	-2.0	0.3	-1.5	-0.6
Lung FVC	0.4	2.2	4.3	-1.5	-1.6	-1.9	-1.1	-0.8	-1.9	-0.9	0.0	-0.9	-1.6	-1.6	-2.0	-2.1
Neuroticism	0.2	0.5	1.4	-0.1	1.2	0.3	-0.4	-0.9	0.6	0.6	-1.2	-0.1	0.0	0.6	-0.0	1.1
Chronotype (morning person)	0.4	0.8	1.8	1.0	0.1	1.4	-0.0	0.4	1.2	1.1	0.6	0.4	1.1	1.2	0.8	1.2
Hair Pigment	0.1	2.0	4.5	1.5	-0.7	1.5	0.4	0.4	1.6	2.1	1.6	-0.5	1.4	1.9	1.9	1.4
Tanning	0.0	0.3	1.0	-0.3	-0.5	1.0	-0.5	-0.5	0.4	0.8	-0.7	0.2	0.0	-0.6	0.4	0.2
Hand grip strength (left)	0.2	0.6	1.6	0.9	-0.8	0.7	0.9	0.9	0.6	0.8	0.7	1.2	1.1	0.4	0.5	-0.0
Number of treatments/medications taken	0.8	1.4	4.2	1.0	-0.2	1.2	1.2	0.7	0.9	1.4	0.5	1.6	0.9	1.1	2.1	1.4
Average weekly spirits intake	0.1	0.2	0.8	0.4	0.2	0.5	0.2	0.2	0.5	0.4	0.2	-0.0	0.3	0.3	0.5	0.9
Sensitivity / hurt feelings	2.2	3.8	7.8	-2.1	1.1	-2.1	-2.2	-2.1	-1.6	-2.0	-2.8	-2.3	-2.1	-0.6	-2.1	-0.5
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.7	-1.0	-0.3	-1.2	-0.7	-1.2	-0.9	0.1	-1.3	-0.4	-0.8	-0.8	-1.1	-1.0
Hearing difficulty/problems: Yes	2.1	3.2	10.2	-2.1	0.7	-1.8	-1.5	-3.2	-1.4	0.3	-1.8	-0.7	-2.1	-2.8	-1.3	-0.7
Relative age of first facial hair	0.4	0.8	2.5	-0.9	-1.5	-0.2	-0.3	0.1	-0.5	-0.0	0.1	-1.6	-0.8	-1.6	-1.0	-0.6
Other serious medical condition/disability diagnosed by doctor	2.9	3.8	7.6	-2.3	-0.6	-2.7	-1.4	-0.4	-2.1	-2.2	-1.3	-2.4	-2.6	-2.2	-1.9	-1.7
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.7	-0.6	1.3	-0.9	-0.8	-1.0	-0.7	-0.9	-0.8	-1.0	-0.7	-0.3	-0.7	-0.3
Ever had hysterectomy (womb removed)	0.2	0.3	1.1	0.1	-0.8	-0.0	0.5	0.8	-0.2	0.4	1.0	0.2	0.1	-0.4	0.5	-0.2
Systolic blood pressure, automated reading	1.5	4.4	7.9	2.4	0.2	2.7	2.0	1.3	2.2	1.7	2.0	2.1	2.3	2.1	2.1	2.8
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	3.8	-0.7	0.2	-0.9	-1.2	-1.9	-0.9	0.2	-1.6	0.0	-0.5	-0.0	0.1	-1.0
Angina	0.3	0.4	2.4	-0.1	1.6	0.3	-0.5	-1.0	0.4	0.4	-0.4	0.4	-0.2	0.3	0.4	0.7
Medication for hormone replacement therapy	0.6	0.7	2.1	-0.5	1.2	-0.6	-0.8	-1.4	-0.5	-0.3	-1.4	-0.6	-0.4	-0.6	-0.6	-0.2
Vitamin and mineral supplements	0.1	0.1	0.8	0.2	0.1	0.2	0.0	-0.2	0.0	-0.5	0.2	0.4	0.2	0.9	-0.2	-0.2
Supplements: Zinc	1.1	1.2	5.0	1.3	0.8	0.5	0.7	0.1	1.2	2.2	0.9	0.2	0.9	0.6	1.6	1.2
Medication: Co-codamol	0.6	0.7	1.6	-0.8	1.2	-1.2	-0.7	-1.3	-0.7	-0.5	-0.9	-0.5	-0.9	-0.9	-0.5	-0.5
Medication: Metformin	0.3	0.5	1.4	0.2	-1.1	-0.7	0.2	0.7	-0.3	-1.2	1.0	-1.1	-0.3	0.2	0.0	0.1
Diabetes (father)	0.7	0.9	2.6	1.1	1.6	0.7	0.2	-0.5	0.6	1.3	-0.3	-0.3	1.2	0.8	1.1	1.3
Diabetes (mother)	0.9	1.2	3.3	-1.5	0.0	-1.4	-0.7	-0.2	-0.7	-1.7	-0.6	-1.6	-1.8	-1.1	-0.5	-0.1
Severe depression (siblings)	0.7	0.8	2.4	-0.2	1.4	-0.6	-1.0	-1.5	-0.5	0.1	-1.3	-1.1	-0.0	-0.5	-1.0	-0.9
Pack years adult smoking proportion	0.9	1.4	2.7	-1.3	0.5	-1.3	-1.3	-1.3	-1.6	-0.5	-0.9	-0.7	-1.0	-1.2	-1.4	-1.4
Impedance of leg (right)	0.2	1.0	3.4	1.7	-0.1	1.6	0.4	0.3	0.7	1.0	0.9	0.6	1.9	0.9	0.5	0.4
Leg fat-free mass (left)	0.0	0.2	0.8	0.4	0.0	-0.5	0.5	0.4	0.2	-0.2	0.3	0.1	0.2	0.9	0.5	0.8
Trunk fat percentage	0.2	0.9	3.2	1.3	0.6	0.4	0.7	0.8	0.6	0.7	1.1	-0.0	1.1	1.8	0.9	1.2
Hand grip strength (right)	0.8	2.3	3.9	1.8	-1.3	1.6	1.3	1.1	1.5	1.7	1.3	1.6	2.0	1.5	1.7	0.8
Townsend deprivation index at recruitment	0.2	0.3	1.1	-0.2	0.6	-0.6	0.3	0.4	0.1	0.5	0.8	-1.0	-0.6	-0.9	0.3	0.4
Current tobacco smoking	0.2	0.3	1.8	-0.2	1.4	-0.3	-0.6	-0.5	-0.5	-0.1	-0.2	-0.2	-0.4	-0.3	0.5	0.1
Average weekly fortified wine intake	0.4	0.4	2.0	-0.1	-0.8	0.0	1.1	1.4	0.5	-0.4	0.8	0.4	-0.4	-0.8	-0.2	-0.0
Maternal smoking around birth	0.5	0.7	2.4	0.8	1.2	0.8	-0.5	-0.5	0.5	0.7	0.2	-0.4	0.9	1.6	1.1	0.8
Fed-up feelings	0.4	0.7	1.9	0.4	0.1	1.3	0.1	-0.8	1.0	1.4	-0.2	0.6	0.6	1.1	1.0	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	1.0	-0.1	0.1	-1.0	-0.0	-0.5	-0.4	0.7	0.3	-0.5	-0.1	-0.8	-0.4	0.1
Relative age voice broke	0.2	0.3	1.3	0.5	-0.8	0.3	0.2	0.7	0.2	-0.5	0.7	-0.8	0.4	1.1	0.1	0.3
Taking other prescription medications	0.1	0.1	0.4	-0.1	-0.4	-0.5	0.2	-0.1	-0.6	0.3	-0.0	-0.4	-0.3	0.2	0.6	-0.2
Age when periods started (menarche)	0.3	0.8	1.9	1.0	-1.3	1.2	-0.1	-0.7	0.4	0.9	-0.2	0.9	1.3	1.4	0.4	-0.2
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	2.6	-1.2	0.6	-0.7	-1.2	-1.6	-1.2	-0.3	-1.3	-0.5	-0.9	-0.6	-1.3	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.7	1.1	1.6	1.2	0.0	-0.3	0.6	0.2	-1.3	0.4	1.3	1.5	0.5	0.9
Tinnitus: Yes, but not now, but have in the past	2.9	3.1	5.7	2.3	1.3	2.1	1.3	1.1	2.0	1.6	0.7	1.4	2.4	2.2	1.9	1.5
Qualifications: CSEs or equivalent	0.7	0.9	2.1	1.0	-1.1	0.7	0.6	-0.2	1.0	1.5	0.8	0.9	1.1	1.0	1.0	0.9
Serious illness, injury or assault to yourself	0.1	0.1	0.2	-0.3	0.3	0.1	-0.2	-0.3	-0.2	0.1	-0.1	-0.5	-0.4	-0.1	0.1	-0.1
High blood pressure	5.8	16.2	26.0	4.6	0.8	4.5	3.6	2.5	4.6	4.0	3.5	4.2	4.4	4.3	5.1	4.2
Hayfever, allergic rhinitis or eczema	0.7	1.4	7.0	-0.6	0.7	-0.7	-1.6	-2.6	-0.7	1.1	-2.1	-1.0	-0.4	-0.2	0.2	-0.3
Multivitamins +/- minerals	0.5	0.7	1.9	-0.5	0.7	-0.7	-1.4	-1.1	-0.8	0.3	-1.2	-1.0	-0.3	-0.8	-0.0	-0.8
Stomach or abdominal pain in last month	0.8	1.0	5.9	-0.8	2.4	0.0	-0.8	-1.6	-0.3	-0.5	-1.3	0.5	-1.0	0.1	-0.3	0.2
Supplements: Glucosamine	0.6	0.7	2.4	1.2	0.7	0.3	0.5	1.1	0.8	0.6	1.2	-0.4	0.9	0.8	0.0	1.5
Diverticular disease/diverticulitis (self-reported)	2.3	2.7	5.6	1.9	0.2	2.4	1.8	1.7	1.7	1.5	1.3	2.0	1.9	1.1	2.1	0.9
Medication: Atenolol	3.3	4.2	7.6	-2.7	0.1	-2.4	-1.8	-1.8	-2.0	-2.5	-1.5	-2.0	-2.8	-1.2	-2.3	-1.8
Medication: Levothyroxine sodium	0.8	1.3	3.7	-1.2	0.2	-1.9	-0.8	-0.6	-1.1	-1.8	-0.6	-1.5	-1.6	-0.4	-0.9	-0.7
Sitting height	0.7	5.0	8.6	2.7	-1.6	2.1	2.7	2.8	2.2	1.2	2.9	2.6	2.5	1.7	1.6	1.5
Chronic bronchitis/emphysema (father)	0.6	0.7	1.7	0.3	1.0	1.0	-0.3	-1.3	0.4	0.6	-1.1	1.1	0.6	1.1	1.0	0.1
High blood pressure (mother)	0.4	0.6	1.9	0.6	0.5	0.6	0.7	-0.2	0.8	0.7	0.6	0.9	0.7	1.4	1.0	0.4
Body mass index (BMI)	0.1	0.5	2.1	-0.3	1.5	-1.3	-0.5	-0.5	-0.5	-0.2	-0.6	-1.1	-0.6	0.2	0.1	0.4
Impedance of leg (left)	0.3	1.6	4.6	1.9	-0.1	2.1	0.5	0.3	1.1	1.5	1.1	0.9	2.1	1.3	0.7	0.5
Leg predicted mass (left)	0.0	0.2	0.8	0.4	0.1	-0.5	0.6	0.5	0.2	-0.2	0.4	0.2	0.2	0.9	0.6	0.8
Trunk fat mass	0.3	1.3	3.4	1.6	0.5	0.4	1.0	1.0	0.8	0.7	1.3	0.3	1.3	1.9	1.2	1.6
Waist circumference	0.1	0.4	1.7	-0.0	1.0	-1.3	-0.2	-0.1	-0.6	-0.3	0.2	-1.3	-0.4	0.4	0.1	0.3
Number of incorrect matches in round	0.6	1.0	2.4	0.8	-0.6	1.0	1.2	0.7	0.9	0.7	1.2	1.5	0.7	0.8	0.3	1.6
Past tobacco smoking	0.1	0.2	0.5	0.5	0.5	-0.4	-0.2	-0.2	-0.7	0.2	-0.5	-0.5	0.4	0.4	-0.4	0.3
Alcohol usually taken with meals	0.3	0.4	1.4	0.3	-0.8	0.5	0.9	1.2	1.0	-0.0	0.6	0.9	0.4	-0.3	-0.3	0.2
Nervous feelings	2.8	5.2	11.7	-2.7	0.6	-2.3	-2.6	-3.4	-2.4	-1.5	-3.0	-1.8	-2.4	-1.8	-2.1	-1.6
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	3.0	-1.0	0.3	-1.1	-0.3	-1.2	-0.5	0.5	-0.7	-0.1	-1.1	-1.7	-1.0	-0.1
Hearing difficulty/problems with background noise	0.4	0.6	2.2	0.0	0.8	0.1	0.3	-1.0	0.7	1.5	0.2	0.9	-0.3	-0.6	0.6	1.4
Hair/balding pattern: Pattern 2	0.6	0.8	2.8	-1.0	0.1	-1.1	-1.0	-1.7	-1.0	0.2	-0.3	-0.7	-0.9	-0.4	-0.9	-0.7
Had menopause	0.4	0.5	1.1	1.0	1.0	0.5	0.4	0.4	0.8	-0.4	0.1	0.7	1.0	1.0	0.3	0.6
Had other major operations	0.6	0.8	3.1	0.5	1.8	-0.5	-0.5	-1.2	-0.7	1.1	-0.6	-0.7	0.3	0.6	1.0	0.8
Forced vital capacity (FVC)	0.1	0.3	0.6	0.3	-0.8	0.5	0.0	-0.0	0.3	0.7	0.6	0.7	0.4	0.8	0.2	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.4	5.2	1.8	2.0	2.2	0.3	-0.0	1.5	0.6	-1.4	1.2	2.1	2.3	0.9	1.5
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	1.0	0.1	0.5	-0.7	0.2	0.3	-0.3	0.2	0.8	-1.0	-0.3	0.3	-0.1	-0.2
Qualifications: None of the above	2.3	5.0	9.7	2.4	-2.0	2.1	3.1	2.9	1.8	1.5	3.0	2.9	2.3	1.5	1.6	0.7
Financial difficulties in last 2 years	0.7	1.0	2.3	-1.0	-0.1	-1.2	-1.4	-0.2	-1.2	-1.3	-0.9	-1.5	-1.1	-0.4	-0.6	-0.7
Mouth/teeth dental problems	0.2	0.4	1.2	1.1	0.0	0.2	0.6	1.1	0.3	-0.2	0.1	0.5	1.0	0.6	0.3	-0.3
Heart attack	0.5	0.6	3.8	-0.5	2.0	0.3	-1.0	-1.4	0.2	0.4	-0.3	-0.2	-0.3	0.6	-0.3	0.3
Allergy	1.3	2.9	14.1	0.8	-1.5	0.7	2.2	3.8	1.1	-1.8	2.7	1.3	0.5	0.5	-0.7	0.7
Pain all over the body in last month	2.7	2.9	5.6	-2.0	-0.3	-2.1	-1.3	-1.3	-2.0	-1.0	-1.5	-1.7	-1.9	-2.1	-1.5	-2.4
Diabetes (self-reported)	0.2	0.3	2.1	0.0	-0.1	-0.8	-0.4	0.0	-0.5	-0.2	0.6	-1.5	-0.3	-0.3	0.1	0.2
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	3.3	-1.3	0.1	-1.2	-1.0	-1.6	-0.8	-0.5	-1.8	-0.9	-1.5	-1.1	-0.2	-0.5
Medication: Ramipril	0.4	0.5	1.7	0.8	1.1	1.1	0.2	0.4	0.6	0.6	0.3	1.3	0.9	0.3	0.6	0.3
Medication: Simvastatin	0.1	0.2	0.5	-0.2	0.5	-0.4	0.1	0.1	-0.7	0.0	-0.4	-0.1	-0.3	-0.5	0.7	-0.1
Fluid intelligence score	0.2	0.5	1.6	0.8	1.3	0.6	-0.1	-0.0	0.7	0.8	0.1	-0.8	0.9	0.8	0.0	0.6
Illnesses of siblings	1.4	1.9	4.0	-1.9	-1.0	-1.3	-1.1	-0.5	-0.8	-1.6	-1.3	-0.7	-1.8	-2.0	-1.5	-1.3
Neuroticism score	0.4	0.7	3.5	-0.4	1.9	-0.3	-0.6	-1.4	0.2	0.2	-1.4	-0.6	-0.4	0.4	-0.4	0.7
Weight	0.2	1.2	2.9	1.5	0.4	0.3	1.0	0.9	0.9	0.8	1.1	0.4	1.2	1.7	1.3	1.6
Impedance of arm (right)	0.1	0.4	0.9	0.5	-0.9	0.9	0.5	0.3	0.3	0.7	1.0	0.4	0.5	0.9	0.1	0.4
Arm fat percentage (right)	0.1	0.4	1.2	-0.2	0.9	-1.0	-0.2	0.0	-0.3	-0.1	0.1	-1.1	-0.5	0.7	-0.1	0.8
Trunk fat-free mass	0.2	0.9	2.2	1.2	-0.4	0.2	1.2	1.2	0.8	0.2	0.9	0.6	1.0	0.9	1.2	1.5
Hip circumference	0.1	0.5	1.6	0.7	1.2	-0.2	0.5	0.2	0.4	0.4	0.1	-0.1	0.4	1.2	0.6	1.3
Time employed in main current job	0.2	0.2	1.8	-0.2	-1.3	0.1	-0.3	0.1	-0.2	0.1	0.5	-0.6	-0.1	0.4	0.0	0.1
Alcohol intake versus 10 years previously	0.5	0.7	2.2	1.0	-1.5	0.5	0.2	0.5	0.3	0.9	1.1	0.1	1.0	1.3	0.8	-0.4
Father’s age at death	0.9	1.2	2.8	-0.9	-0.3	-1.3	-1.3	-1.5	-0.9	-0.3	-0.9	-1.7	-0.9	-1.3	-1.3	-0.6
Worrier / anxious feelings	0.3	0.6	2.7	0.7	1.0	0.1	0.4	-0.1	0.7	1.1	0.1	-0.4	0.5	0.5	0.8	1.6
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	6.4	-1.2	0.5	-1.7	-1.6	-1.9	-1.3	-0.2	-1.8	-2.5	-1.2	-0.6	-0.9	-0.4
Falls in the last year	0.4	0.5	2.4	0.2	0.0	0.3	-0.5	-1.1	-0.2	1.0	-0.6	0.1	0.4	0.9	1.6	-0.6
Hair/balding pattern: Pattern 3	0.9	1.4	4.1	0.6	-1.7	0.8	1.7	2.0	0.9	-0.3	1.6	1.6	0.6	0.1	0.1	0.7
Number of live births	0.8	1.1	3.2	-1.1	0.1	-1.8	-0.0	0.3	-0.9	-0.7	0.1	-1.4	-1.1	-1.6	-1.2	-1.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.6	-0.9	-0.1	-0.7	-1.3	-1.1	-0.8	-0.3	-0.6	-0.7	-0.8	0.1	-0.9	-1.0
Pulse rate	0.3	0.5	3.5	0.5	-1.9	-0.3	0.4	-0.1	-0.2	0.4	0.2	1.0	0.6	0.3	1.0	-0.4
Happiness	0.4	0.4	1.5	0.1	0.8	0.5	0.7	-0.2	0.9	1.2	0.2	0.5	0.0	0.2	0.3	1.2
Noisy workplace	0.6	0.7	1.5	0.7	-1.0	0.1	1.1	1.1	0.6	0.6	1.2	1.0	0.5	-0.5	1.2	0.2
Qualifications: A levels/AS levels or equivalent	2.2	4.9	8.1	-2.2	0.6	-2.7	-2.8	-2.2	-2.9	-2.0	-2.1	-2.3	-2.2	-1.4	-2.3	-1.9
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	2.0	0.3	-1.4	0.3	0.6	0.5	-0.0	0.4	0.6	0.9	0.4	-0.5	0.2	-1.1
Mouth/teeth dental problems: Dentures	0.9	1.5	3.8	-1.6	1.1	-0.9	-1.5	-2.0	-1.1	-0.8	-1.8	-0.7	-1.4	-0.8	-0.9	-0.2
Asthma	0.4	0.8	4.7	0.4	0.5	0.9	-0.3	-1.6	0.5	2.2	-0.6	-0.1	0.6	-0.0	1.0	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	5.3	0.4	-2.3	0.4	1.1	1.7	0.7	0.2	1.2	0.5	0.3	-0.7	0.4	0.2
Medication: Cholesterol lowering	0.1	0.2	0.8	0.0	0.1	-0.1	-0.5	-0.2	-0.9	0.3	-0.3	-0.1	0.0	-0.1	0.8	-0.4
Depression (self-reported)	0.1	0.1	1.0	-0.2	-0.0	-0.3	-0.0	-0.2	-0.3	1.0	0.0	0.2	-0.1	-0.2	-0.2	-0.4
Medication: Lansoprazole	0.2	0.2	0.8	0.0	0.7	0.2	0.4	-0.1	0.0	0.4	0.1	0.9	0.0	0.1	0.7	0.2
Prospective memory result	0.8	1.0	5.5	0.9	-2.4	0.3	0.9	1.7	-0.1	-0.0	0.9	0.3	0.9	0.5	0.4	-0.5
Lung cancer (father)	0.3	0.4	2.3	-0.3	-1.5	-0.6	-0.0	0.6	-0.1	-0.5	0.8	-0.2	-0.5	-0.6	-0.5	0.0
Illnesses of mother	1.4	1.8	3.8	1.3	-0.2	1.5	1.4	2.0	1.8	1.4	1.8	1.1	1.2	0.5	0.5	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.8	-0.5	-0.9	-0.4	-0.8	-0.7	-0.5	-0.0	0.2	-0.5	-0.5	0.3	-0.2	-0.4
Pulse wave Arterial Stiffness index	0.5	0.5	1.3	-0.2	1.2	-0.5	-0.7	-1.1	-0.9	0.0	-1.1	-0.3	0.1	-0.8	-0.5	-0.8
Impedance of arm (left)	0.3	1.3	3.2	1.1	-1.1	1.5	1.2	1.0	0.8	1.1	1.8	1.0	1.1	1.2	0.5	0.6
Arm fat mass (right)	0.1	0.3	0.9	0.3	0.8	-0.7	0.0	0.1	-0.0	0.2	0.2	-0.7	0.0	0.8	0.2	1.0
Trunk predicted mass	0.2	0.9	2.3	1.2	-0.4	0.2	1.1	1.2	0.8	0.3	0.9	0.6	1.0	1.0	1.2	1.5
Standing height	1.1	10.8	17.2	4.2	-2.2	3.5	3.5	3.2	3.1	2.3	3.6	3.5	4.1	3.4	2.9	2.7
Length of working week for main job	3.9	4.3	9.4	2.2	-0.4	1.7	1.9	0.9	2.7	3.1	1.9	2.3	2.2	2.2	2.5	1.7
Exposure to tobacco smoke at home	1.5	1.6	3.5	-1.2	1.8	-0.8	-1.9	-1.2	-1.1	-1.2	-1.6	-1.7	-1.2	-0.2	-0.7	-0.9
Breastfed as a baby	0.3	0.4	1.3	1.1	-0.1	0.4	0.2	1.0	0.1	-0.3	0.3	0.1	1.0	0.9	0.6	0.3
Tense / ‘highly strung’	0.5	0.9	3.4	0.4	1.0	1.2	0.1	-0.7	1.0	1.8	-0.5	1.0	0.6	0.9	0.9	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	2.7	-0.1	-0.7	0.3	0.7	0.1	0.6	1.7	0.4	-0.4	-0.1	-0.9	0.5	0.5
Hair/balding pattern: Pattern 4	0.7	1.8	4.5	1.5	0.5	2.1	0.5	1.4	1.5	1.2	0.3	0.1	1.7	1.4	2.1	1.2
Birth weight of first child	1.0	1.9	8.7	-0.1	-3.0	-0.8	1.2	2.4	-0.5	-1.0	2.0	-0.2	-0.3	-1.4	-0.7	-0.5
Peak expiratory flow (PEF)	0.3	0.8	2.4	0.6	1.0	1.1	-0.4	-0.5	0.7	1.5	0.3	1.1	1.0	1.2	0.6	-0.5
Pulse wave reflection index	0.5	0.6	3.5	0.1	1.9	-0.2	-0.6	-1.1	-0.1	-0.0	-1.2	-0.7	0.1	0.7	-0.1	0.7
Ever highly irritable/argumentative for 2 days	0.7	0.9	2.1	-1.2	0.5	-1.1	-0.8	-0.4	-1.1	-1.0	-0.8	-1.0	-1.5	-1.0	-0.5	-0.7
Loud music exposure frequency	0.6	0.6	2.7	-0.5	-0.1	-1.2	-0.7	-0.5	-0.9	-0.8	-0.6	-1.7	-0.7	-0.6	-0.6	-0.1
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	2.5	-1.0	0.3	-1.6	-0.6	-0.7	-1.1	-0.6	-0.2	-1.0	-1.1	-1.4	-1.2	-0.4
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	2.2	-1.4	-0.2	-0.6	-1.3	-1.5	-0.7	-0.3	-1.1	-1.4	-1.2	-0.7	-1.1	-0.8
Blood clot in the leg (DVT)	0.9	1.2	3.6	-0.6	-0.4	-1.4	-1.3	-1.9	-1.6	-0.5	-1.7	-0.9	-0.6	-0.2	0.1	-1.1
Medication: Paracetamol	0.3	0.5	2.0	0.3	-0.7	0.6	0.5	0.0	0.8	1.4	0.5	0.1	0.2	-0.4	0.9	1.3
Headache pain in last month	0.1	0.2	0.6	-0.4	-0.5	-0.2	-0.4	-0.5	-0.1	-0.3	-0.5	-0.8	-0.3	-0.4	-0.3	-0.0
Medication for cholesterol, blood pressure or diabetes	2.9	4.8	8.8	-2.4	-0.1	-2.3	-2.1	-2.0	-1.9	-2.1	-2.6	-2.5	-2.3	-2.1	-3.0	-1.9
Glaucoma (self-reported)	0.3	0.4	1.2	0.6	1.0	0.4	-0.2	-0.9	-0.1	1.1	-0.2	-0.4	0.7	0.8	0.5	0.4
Gout (self-reported)	0.4	0.6	2.0	0.6	-1.3	0.2	0.9	0.9	-0.1	0.7	1.4	0.1	0.4	0.0	0.8	-0.4
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	3.2	-0.9	-0.1	-1.8	-0.4	-0.5	-1.1	-1.6	-0.4	-1.0	-1.2	-0.2	-0.7	-0.8
Medication: Amlodipine	3.6	5.0	9.6	2.2	-0.4	2.2	2.2	1.7	2.7	2.4	2.6	3.1	2.2	1.5	2.9	1.7
Medication: Ventolin 100micrograms inhaler	5.4	6.9	14.3	2.8	-0.4	3.0	2.2	0.6	3.3	3.8	2.3	1.6	2.8	2.4	3.4	3.1
Birth weight	2.2	4.8	11.8	2.3	-2.0	1.6	3.2	3.4	1.9	1.4	2.5	2.4	2.0	0.7	2.0	1.5
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.8	1.0	-0.4	0.2	0.9	1.3	0.9	0.2	1.0	-0.9	0.7	0.5	1.1	1.1
High blood pressure (siblings)	0.4	0.6	1.6	0.7	1.3	1.0	-0.1	-0.5	0.4	0.8	-0.2	0.7	1.0	1.2	0.1	-0.1
Forced vital capacity (FVC), Best measure	0.1	0.3	1.8	0.1	-1.4	0.1	-0.1	0.0	0.0	0.3	1.0	0.1	0.1	0.6	0.4	-0.2
Body fat percentage	0.2	0.8	2.4	1.2	0.9	0.2	0.6	0.7	0.5	0.5	0.9	-0.2	0.9	1.5	0.8	1.3
Leg fat percentage (right)	0.2	0.6	2.6	1.1	1.6	-0.1	0.2	0.3	0.3	0.5	0.5	-0.5	0.8	1.0	0.6	1.2
Arm fat-free mass (right)	0.2	1.0	2.3	1.5	0.1	0.2	0.9	0.9	0.8	0.3	0.7	0.5	1.3	1.5	1.2	1.3
Exposure to tobacco smoke outside home	0.8	1.0	2.2	-1.2	1.0	-1.1	-0.9	-1.1	-0.9	0.2	-1.5	-0.8	-1.2	-1.4	-0.7	-0.6
Comparative body size at age 10	1.1	3.1	9.8	-2.0	1.9	-1.5	-2.5	-3.1	-1.1	-0.4	-2.6	-1.5	-1.9	-0.6	-1.0	0.2
Number of full brothers	0.1	0.1	0.6	-0.3	0.1	-0.7	0.0	0.1	-0.5	0.0	0.5	-0.3	-0.5	-0.1	0.1	-0.7
Worry too long after embarrassment	0.5	0.8	5.8	-0.1	2.4	-0.1	-0.5	-1.2	0.6	0.1	-0.7	-0.6	-0.2	0.6	-0.5	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	3.3	1.3	-0.9	1.4	1.5	1.8	1.1	0.8	1.4	0.7	1.1	1.0	1.3	1.2
Wheeze or whistling in the chest in last year	1.5	2.6	12.4	1.6	-0.2	1.2	1.5	0.1	1.3	3.5	1.9	1.2	1.4	0.3	2.2	1.3
Number of children fathered	1.9	2.1	3.9	1.7	-0.3	2.0	1.7	1.6	1.4	1.6	1.8	1.7	1.6	-0.2	1.2	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.5	-0.9	0.6	-0.6	-0.8	-0.6	-1.1	-0.9	-1.1	-0.5	-0.8	-0.4	-1.1	-1.2
Age at first live birth	0.6	1.1	2.7	-1.0	0.0	-0.5	-1.3	-1.5	-0.8	-0.5	-1.6	-0.4	-0.7	-0.6	-1.1	-1.6
Pulse wave peak to peak time	0.7	0.8	1.9	0.4	-1.3	0.8	0.9	1.3	1.1	0.2	1.4	0.5	0.2	0.9	0.6	1.0
Health satisfaction	0.4	0.5	1.6	-0.6	0.2	-1.2	-0.4	-0.9	-1.3	-0.7	-0.8	-0.5	-0.8	-0.0	0.0	-0.6
Shortness of breath walking on level ground	0.7	0.8	2.4	1.0	1.2	0.4	0.1	-0.4	0.1	1.3	-0.5	1.0	1.1	1.3	1.5	0.1
Qualifications: College or University degree	1.0	3.0	7.5	-1.7	1.0	-2.0	-2.0	-1.6	-1.8	-1.7	-1.9	-2.7	-1.9	-1.0	-1.5	-0.9
Eye problems/disorders: None of the above	1.6	1.8	4.8	1.3	-0.9	1.7	1.8	2.2	1.6	0.7	1.8	1.3	1.3	-0.5	0.4	0.5
Mouth/teeth dental problems: Loose teeth	0.7	0.9	2.2	-1.3	-1.0	-1.2	-0.6	-1.0	-1.0	-0.9	-0.1	-0.6	-1.5	-0.3	-0.2	-1.2
Emphysema/chronic bronchitis	0.7	0.7	2.9	0.6	0.8	1.0	0.3	-1.0	0.4	1.7	-0.3	1.2	0.7	0.4	1.1	0.2
Medication for pain relief, constipation, heartburn	0.4	0.7	3.7	0.4	1.9	0.1	-0.6	-0.3	0.1	-0.4	-0.6	-0.5	0.5	1.8	-0.5	-0.2
Neck or shoulder pain in last month	0.9	1.2	4.1	0.8	0.9	1.3	0.4	-0.5	1.2	2.0	0.3	1.0	0.9	1.1	0.9	1.7
Medication: Blood pressure	4.8	8.5	14.2	3.0	0.5	2.9	3.0	2.4	3.1	2.6	3.6	3.8	2.9	2.6	3.5	2.6
Angina (self-reported)	0.4	0.5	2.6	-0.3	1.6	0.1	-0.7	-1.4	0.2	0.3	-0.8	0.5	-0.3	0.1	0.2	0.5
Migraine (self-reported)	3.2	3.9	9.9	-2.7	-0.1	-2.7	-1.2	-0.6	-1.8	-2.6	-1.2	-2.2	-3.1	-2.0	-1.8	-0.8
Medication: Ibuprofen	0.4	0.4	1.5	0.4	-1.2	0.2	0.7	1.1	0.7	0.2	0.7	0.2	0.3	-0.6	0.5	0.7
Medication: Allopurinol	0.3	0.3	0.9	0.8	-0.8	0.2	0.5	1.0	-0.3	0.1	0.9	-0.2	0.7	0.0	0.6	-0.4
Medication: Omeprazole	1.2	1.4	3.4	1.0	0.5	1.5	1.2	1.1	1.5	1.0	1.0	1.8	1.0	1.4	1.4	0.6
Medication: Seretide 50 evohaler	2.1	2.4	5.4	1.3	-0.7	2.1	1.6	0.5	1.9	2.3	1.2	2.0	1.5	1.1	1.8	0.9
Mean time to correctly identify matches	0.2	0.3	1.0	0.1	-0.5	-0.0	0.9	0.9	-0.1	0.5	0.7	0.5	-0.1	-1.0	0.1	0.2
Heart disease (mother)	1.3	1.6	3.4	-1.2	-1.1	-1.7	-1.5	-1.8	-1.9	-1.2	-1.1	-0.8	-1.2	-0.2	-0.6	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	3.7	1.1	-1.9	1.6	0.7	-0.1	1.2	1.9	0.6	0.3	1.2	1.0	1.1	1.5
Whole body fat mass	0.2	0.7	2.0	1.2	0.4	0.0	0.7	0.8	0.5	0.4	0.9	-0.1	0.9	1.4	0.8	1.2
Leg fat mass (right)	0.1	0.5	1.6	1.0	1.3	-0.2	0.2	0.2	0.3	0.3	0.4	-0.2	0.8	1.2	0.6	1.1
Arm predicted mass (right)	0.2	0.8	1.8	1.3	0.3	0.2	0.8	0.7	0.8	0.3	0.5	0.5	1.1	1.3	1.2	1.3
Pulse rate, automated reading	0.5	1.6	5.8	1.0	-2.4	0.0	1.4	1.1	0.4	0.3	1.0	2.3	0.9	0.4	1.6	0.5
Alcohol intake frequency.	0.2	0.5	1.1	-0.6	-1.1	-1.0	0.0	0.6	-0.7	-0.7	0.5	-0.3	-0.6	-0.7	-0.6	-0.9
Comparative height size at age 10	1.6	8.7	16.0	3.6	-1.6	2.7	3.7	3.6	2.7	1.5	4.0	2.9	3.2	2.8	2.2	2.4
Number of full sisters	0.7	0.8	2.8	0.8	-0.9	0.7	1.2	1.7	1.2	0.3	1.4	-0.1	0.5	-0.1	0.8	0.6
Suffer from ‘nerves’	0.5	0.8	2.0	-0.9	0.5	-1.1	-0.9	-1.4	-0.8	0.3	-0.3	-1.2	-1.0	-1.1	-0.8	0.1
Overall health rating	0.4	0.9	3.7	-0.7	1.6	-0.5	-1.0	-1.9	-0.7	-0.4	-1.5	-0.2	-0.7	0.2	-0.5	0.2
Chest pain or discomfort	1.3	1.9	4.8	1.5	0.4	1.4	0.7	-0.5	1.4	2.2	0.6	0.9	1.4	1.3	2.2	1.7
Had major operations	0.2	0.2	0.6	0.2	-0.6	0.6	0.1	0.4	0.5	0.4	-0.1	-0.7	0.1	0.2	0.8	0.3
Age at last live birth	0.2	0.2	1.3	-0.3	-0.6	-0.2	-0.3	-0.5	-0.4	0.2	-0.8	0.2	-0.0	-0.5	0.1	-1.1
Family relationship satisfaction	0.5	0.6	1.8	0.6	1.3	-0.1	0.7	0.2	0.3	1.3	1.3	0.7	0.3	0.8	0.3	0.4
Leg pain on walking	2.2	2.8	6.1	1.8	-0.2	2.1	1.5	0.8	2.1	2.5	1.8	1.5	2.0	1.3	1.7	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.7	0.4	-0.2	0.2	-0.7	-0.4	-0.1	0.5	-0.2	-0.8	0.5	0.6	0.4	0.3
Commuting to job workplace: Car/motor vehicle	1.4	1.7	2.8	1.4	0.0	1.7	1.0	1.2	1.7	1.1	0.9	0.8	1.5	1.3	1.5	1.7
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.4	-0.4	0.0	-0.2	0.6	0.1	0.3	-0.5	0.0	0.4	-0.5	0.3	-0.7	0.5
Medication: Aspirin	0.2	0.3	1.6	-0.1	-1.3	-0.2	0.6	0.5	-0.4	-0.6	0.2	0.5	-0.3	-0.5	0.8	0.1
Supplements: Vitamin C	1.3	1.6	3.3	1.4	0.2	1.4	1.3	0.7	1.7	1.6	0.9	1.2	1.2	1.0	1.1	1.8
Knee pain experienced in last month	2.9	4.5	7.2	2.2	-2.5	2.7	2.0	1.3	2.3	2.5	2.3	1.9	2.4	1.6	2.0	1.4
Hypertension (Self-reported)	5.8	16.2	26.1	4.5	1.0	4.5	3.6	2.4	4.8	4.1	3.5	4.1	4.4	4.3	5.1	4.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	3.9	1.3	-0.5	0.9	1.4	2.0	0.8	0.1	0.9	1.1	1.1	0.7	1.2	0.4
Illnesses of father: Heart disease	0.4	0.6	2.3	-0.4	-0.1	-0.5	-0.8	-1.5	-0.9	-0.4	-1.2	-0.5	-0.5	1.0	0.7	0.5
Illnesses of siblings: Diabetes	0.1	0.1	0.4	0.4	0.3	-0.3	0.1	-0.3	-0.5	0.6	0.0	-0.0	0.3	-0.0	0.4	0.5
Smoking status: Previous	0.1	0.1	0.3	-0.4	-0.5	0.4	0.2	0.3	0.6	-0.4	0.2	0.5	-0.2	-0.2	0.1	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.7	1.0	-1.0	1.0	0.8	-0.2	1.0	1.6	0.7	0.9	1.0	0.6	1.4	1.1
Whole body fat-free mass	0.1	0.5	1.3	0.9	-0.1	-0.2	0.8	0.7	0.5	0.0	0.5	0.4	0.7	1.0	0.9	1.1
Leg fat-free mass (right)	0.1	0.3	1.2	0.6	-0.1	-0.2	0.7	0.4	0.5	0.2	0.4	0.4	0.3	1.1	0.7	0.9
Arm fat percentage (left)	0.1	0.4	1.1	-0.2	1.1	-1.0	-0.3	-0.1	-0.4	-0.2	0.1	-1.0	-0.5	0.7	-0.1	0.8
Average weekly red wine intake	0.3	0.4	0.7	-0.9	0.8	-0.1	-0.8	-0.3	-0.2	-0.8	-0.8	-0.6	-0.7	-0.8	-0.4	-0.3
Handedness (chirality/laterality): Left-handed	0.2	0.3	1.1	-0.1	0.1	0.6	0.8	0.4	0.7	0.5	0.5	1.0	-0.1	-0.1	-0.3	0.2
Mood swings	0.5	0.9	3.5	-0.7	1.1	0.3	-1.1	-1.9	0.3	0.3	-1.9	-0.2	-0.6	0.7	-0.3	0.3
Loneliness, isolation	0.6	0.8	3.8	-0.4	1.9	-0.2	-1.1	-1.1	-0.3	-0.2	-1.1	-0.9	-0.3	0.2	-1.2	-0.1
Long-standing illness, disability or infirmity	0.3	0.5	1.0	-0.6	-0.1	-0.7	-0.6	-0.3	-0.9	-0.8	-0.1	-1.0	-0.7	0.4	-0.8	-0.9
Ever had bowel cancer screening	0.4	0.5	1.8	0.2	-1.3	-0.4	0.6	0.7	-0.7	-0.3	0.5	0.0	0.3	-1.1	0.1	-1.1
Diabetes diagnosed by doctor	0.3	0.4	1.8	-0.3	-0.0	-1.1	-0.5	-0.3	-0.8	-0.4	0.3	-1.4	-0.6	-0.7	-0.2	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	2.9	3.1	7.2	-2.3	-1.8	-2.0	-1.0	-0.4	-1.7	-1.4	-0.4	-1.8	-2.4	-2.7	-1.4	-1.8
Friendships satisfaction	1.8	2.3	4.5	1.4	2.1	1.9	1.1	0.6	2.0	1.8	1.0	1.4	1.5	1.7	0.7	1.5
Qualifications: nursing, teaching	0.9	1.4	3.6	-1.0	1.8	-0.5	-1.9	-1.6	-0.5	-0.5	-1.9	-1.3	-0.7	-0.7	-0.6	-1.0
Commuting to job workplace: Walk	0.2	0.2	0.9	-0.6	-0.3	-0.0	0.0	-0.1	-0.3	-0.2	-0.2	1.0	-0.6	-0.5	-0.1	-0.1
Eye problems/disorders: Cataract	0.3	0.4	0.9	-0.8	-0.1	-0.9	-0.7	-0.6	-0.6	-0.2	-0.8	-0.8	-1.0	-0.4	-0.0	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.9	0.5	-0.6	0.5	0.4	0.5	0.3	0.5	0.9	0.1	0.5	0.1	0.2	0.9
Medication for cholesterol	0.7	1.1	8.5	-0.2	-2.9	-0.2	0.4	1.0	-0.2	-0.1	1.5	-0.2	-0.2	-1.2	-0.7	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.8	-0.7	0.3	-0.6	-0.5	0.6	-0.6	-1.6	-0.2	-1.7	-0.8	-1.1	-1.1	-0.4
Back pain experienced in last month	1.3	1.9	6.5	1.4	1.5	1.2	0.6	-0.7	1.1	2.5	0.2	1.3	1.6	1.8	1.4	1.1
Mineral and other dietary supplements	0.5	0.7	2.0	-1.2	0.1	0.2	-0.3	-1.2	-0.2	-0.7	-1.1	1.4	-0.8	-0.1	-0.4	-1.3
Breast cancer (self-reported)	0.6	0.7	3.5	0.5	-1.9	0.6	0.7	0.4	0.9	0.2	1.1	0.7	0.4	0.9	0.4	0.7
Asthma (self-reported)	0.5	0.9	5.3	0.7	0.4	1.0	0.0	-1.2	0.7	2.3	-0.1	0.0	0.8	0.2	1.3	0.8
Osteoporosis (self-reported)	0.4	0.6	1.8	0.6	-1.2	0.1	1.4	1.3	0.2	0.2	0.7	1.0	0.5	0.2	0.1	0.2
Osteoarthritis (self-reported)	0.4	0.5	2.1	0.1	-1.4	-0.9	0.8	0.9	0.1	0.3	1.1	-0.3	-0.1	-0.3	-0.2	-0.2
Medication: Aspirin	0.3	0.3	1.4	0.3	-0.9	-0.1	0.8	0.7	-0.2	-0.1	0.4	0.7	0.1	-0.4	1.2	0.3
Medication: Gliclazide	0.7	0.8	3.5	-0.5	-1.9	-0.9	-0.6	-0.3	-1.1	-1.0	0.3	-1.4	-0.5	-0.1	-0.4	-1.0
Illnesses of father: None of the above (group 1)	0.7	0.9	3.1	0.4	-1.0	0.4	1.4	1.8	1.0	0.8	1.1	1.0	0.4	-0.8	0.0	-0.0
Smoking status: Current	0.2	0.3	1.5	-0.3	1.2	-0.4	-0.6	-0.3	-0.6	-0.5	-0.2	-0.4	-0.6	-0.3	0.3	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	2.5	-1.0	-0.9	-1.0	-1.5	-1.3	-1.5	-1.6	-1.4	-1.4	-0.9	0.1	-1.1	-1.2
Whole body water mass	0.1	0.6	1.7	1.0	-0.2	-0.1	0.9	0.9	0.7	0.1	0.7	0.5	0.7	1.1	1.0	1.3
Leg predicted mass (right)	0.1	0.3	1.2	0.5	-0.2	-0.3	0.6	0.4	0.4	0.1	0.4	0.4	0.3	1.1	0.7	0.9
Arm fat mass (left)	0.1	0.3	1.2	0.4	0.9	-0.6	0.2	0.3	0.1	0.2	0.4	-0.7	0.1	0.8	0.4	1.1
Number of self-reported non-cancer illnesses	0.6	1.0	3.3	0.8	1.0	0.5	0.5	-0.4	0.8	1.8	0.3	0.6	0.7	1.1	1.8	1.2
Average weekly champagne plus white wine intake	0.9	1.2	5.3	-1.2	-1.0	-1.4	-1.0	-0.3	-0.9	-0.8	-0.0	-2.3	-1.4	-0.9	-0.4	-0.4
Miserableness	0.3	0.4	1.2	0.2	-1.1	0.8	0.5	-0.0	0.7	1.1	0.1	-0.1	0.2	0.7	0.6	1.0
Guilty feelings	0.3	0.5	3.0	0.1	1.7	0.3	0.3	-0.3	0.3	-0.1	-0.7	1.0	-0.0	0.9	-0.3	1.0
Wears glasses or contact lenses	0.8	0.9	2.5	-0.5	-0.8	-1.6	0.3	1.0	-0.8	-0.2	1.3	-1.0	-0.9	-1.5	-0.9	-0.1
Ever taken oral contraceptive pill	3.9	4.4	8.1	-2.4	-0.2	-2.8	-1.9	-0.9	-2.6	-2.3	-0.8	-2.6	-2.7	-2.3	-1.9	-1.9
Hearing aid user	1.5	1.7	2.9	-1.2	1.1	-1.7	-1.4	-1.1	-1.5	-0.6	-1.4	-1.3	-1.2	-1.7	-1.3	-1.1
Mother’s age at death	0.3	0.4	2.0	-0.5	0.2	-0.7	-0.1	-0.4	-0.9	0.1	-0.6	-0.4	-0.4	-1.4	-0.5	-0.9
Financial situation satisfaction	1.3	1.6	5.2	-1.2	-1.4	-1.9	-1.4	-0.8	-1.7	-0.7	-0.3	-2.3	-1.2	-1.1	-0.8	-0.5
Tinnitus: Yes, now most or all of the time	4.4	5.1	10.2	-2.3	1.1	-2.2	-3.1	-2.8	-2.3	0.1	-1.7	-2.9	-2.1	-3.2	-1.6	-1.9
Commuting to job workplace: Public transport	1.9	2.3	4.1	-1.1	1.3	-1.7	-1.6	-1.8	-2.0	-1.1	-2.0	-1.3	-1.1	-1.2	-1.2	-1.8
Eye problems/disorders: Glaucoma	0.5	0.6	2.1	0.4	0.9	0.8	-0.5	-1.3	0.1	1.2	-0.4	0.2	0.6	1.4	0.5	0.2
Medication: Blood pressure	1.7	3.2	6.1	1.8	1.7	2.1	1.1	0.4	2.0	1.8	0.8	1.4	1.9	2.5	2.4	2.0
Pain type(s) experienced in last month: Hip pain	2.0	2.5	4.6	1.7	-0.3	1.9	1.9	1.8	1.8	1.1	1.4	1.0	1.5	1.3	2.1	1.6
Supplements: Fish oil (including cod liver oil)	1.4	1.8	6.8	1.8	-1.4	0.3	1.3	2.6	0.7	0.8	2.0	-0.6	1.4	0.3	0.8	1.4
High cholesterol (Self-reported)	1.7	3.1	7.1	-1.6	1.0	-2.0	-2.2	-1.1	-2.7	-2.2	-2.2	-1.8	-1.7	-0.6	-0.9	-1.6
Medication: Bendroflumethiazide	0.4	0.7	1.7	0.4	1.0	0.7	-0.1	-0.6	0.5	0.7	0.4	0.8	0.4	1.3	1.3	1.2
Medication: Paracetamol	0.4	0.6	2.3	0.6	0.2	0.8	0.4	-0.0	1.0	1.4	0.2	0.4	0.6	0.1	1.0	1.5
Medication: Lisinopril	2.3	3.0	12.2	1.5	1.8	1.3	0.5	-0.1	2.0	1.9	1.4	0.5	1.3	3.5	1.6	2.4
Medication: Atorvastatin	3.7	4.5	7.3	-2.4	2.1	-2.2	-2.6	-2.2	-2.2	-1.8	-2.7	-2.1	-2.5	-1.7	-1.3	-1.5
Illnesses of father: High blood pressure	0.2	0.2	1.0	0.5	1.0	0.5	-0.3	0.4	-0.1	0.1	0.1	-0.3	0.5	0.4	0.1	0.2
Alcohol drinker status: Never	0.4	0.5	1.4	-0.9	0.0	-0.7	0.6	1.2	0.0	-0.6	0.6	-0.1	-1.0	-1.1	-0.5	0.0
Ever smoked	0.1	0.3	0.9	-0.5	-0.1	0.4	0.2	-0.2	0.9	0.5	0.6	0.3	-0.6	-0.6	0.8	0.0
Basal metabolic rate	0.1	0.7	1.9	1.1	-0.0	-0.0	1.0	0.8	0.7	0.3	0.8	0.4	0.8	1.2	1.0	1.4
Leg fat percentage (left)	0.2	0.7	2.3	1.1	1.5	0.2	0.3	0.2	0.5	0.8	0.5	-0.3	1.0	1.2	0.7	1.1
Arm fat-free mass (left)	0.2	0.8	1.8	1.3	0.3	0.1	0.9	0.8	0.9	0.6	0.7	0.3	1.1	1.2	1.2	1.3
Number of operations (self-reported)	0.3	0.4	1.5	0.0	1.2	-0.2	-0.2	-0.7	-0.0	0.9	-0.4	-0.9	-0.2	0.3	1.2	0.4
Average weekly beer plus cider intake	0.7	0.9	2.5	1.0	-0.2	1.6	0.7	1.0	1.1	1.1	1.0	1.2	1.2	-0.0	0.8	0.2
Irritability	0.6	1.0	4.0	0.4	0.9	0.5	-1.3	-1.8	-0.1	0.8	-2.0	0.0	0.7	1.0	0.4	-0.3
Risk taking	3.3	4.9	9.2	-2.4	2.2	-2.5	-2.8	-3.0	-2.1	-0.9	-2.4	-2.5	-2.3	-1.4	-1.3	-1.9
Ever had prostate specific antigen (PSA) test	2.5	2.9	8.3	1.2	-1.4	1.4	2.6	2.8	1.6	0.9	2.9	2.0	1.0	0.3	0.6	0.7
Fractured/broken bones in last 5 years	0.6	0.8	3.5	-0.5	0.2	-0.7	-1.1	-1.9	-1.1	0.6	-0.8	-1.1	-0.4	-0.6	0.3	-0.9
Age started oral contraceptive pill	1.5	1.9	5.6	1.6	-0.7	1.4	1.9	2.4	1.0	0.1	1.5	1.5	1.5	1.2	0.9	0.5
Diastolic blood pressure, automated reading	1.3	4.0	8.9	1.9	0.9	2.2	1.9	1.1	2.3	1.6	1.5	2.5	1.8	2.0	2.2	3.0
Ever depressed for a whole week	0.2	0.3	1.8	-0.2	1.3	-0.2	-0.6	-0.3	-0.5	0.0	-0.6	-0.3	-0.3	0.1	-0.4	-0.7
Unable to work because of sickness or disability	2.2	2.9	6.0	-2.3	0.9	-1.9	-1.9	-1.3	-1.4	-0.8	-1.3	-2.4	-2.3	-1.7	-1.2	-1.7
Commuting to job workplace: Cycle	1.0	1.2	3.1	-1.0	-0.9	-1.1	-1.0	-0.4	-1.3	-1.8	-0.9	-1.1	-1.1	-0.3	-1.0	-1.3
Myopia	0.7	1.0	4.1	0.6	-2.0	-0.5	1.0	1.1	0.4	0.8	2.0	-0.1	0.1	-0.6	0.5	0.7
Vascular/heart problems diagnosed by doctor	5.2	14.3	21.4	-4.2	-0.8	-4.3	-3.5	-2.6	-4.2	-3.4	-3.5	-4.1	-4.1	-4.3	-4.6	-3.7
Cholesterol lowering medication	1.8	2.6	5.7	-1.4	2.2	-2.0	-1.4	-1.2	-2.0	-1.9	-2.4	-1.7	-1.6	-0.5	-0.6	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	1.3	0.4	0.3	0.6	0.5	0.2	0.5	0.5	0.4	1.1	0.4	0.6	0.6	-0.2
Pain experienced in last month	0.3	0.5	2.7	-0.1	-0.4	-0.2	0.5	1.6	-0.0	-1.6	0.6	0.3	-0.2	-0.5	-0.2	-0.1
Supplements: Calcium	1.0	1.1	3.5	-0.6	0.9	-1.9	-0.7	-0.6	-1.6	-0.8	-0.9	-0.8	-0.8	-0.8	-0.7	-1.5
Basal cell carcinoma (self-reported)	0.5	0.5	2.8	0.3	-1.7	0.1	0.8	1.2	0.2	-0.3	0.3	-0.1	0.0	-0.6	0.9	0.9
Heart attack/myocardial infarction (self-reported)	0.5	0.7	4.8	-0.4	2.2	0.2	-0.8	-1.4	0.3	0.4	-0.4	-0.0	-0.3	0.6	-0.2	0.3
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	4.1	-0.6	-0.1	-1.3	-1.4	-2.0	-1.7	-0.5	-1.9	-1.1	-0.6	-0.3	-0.1	-1.2
Heart disease (siblings)	0.3	0.3	1.5	0.4	0.7	-0.2	-0.2	-1.0	0.0	0.7	0.4	0.1	0.4	1.2	0.5	0.3
Alcohol drinker status: Previous	0.9	1.0	2.9	-1.0	-0.2	-1.7	-0.7	-1.1	-1.4	-1.0	-1.0	-0.7	-1.0	-1.1	-0.4	-0.9
Pack years of smoking	1.2	1.7	3.7	-1.4	-0.1	-1.5	-1.3	-1.0	-1.9	-1.1	-1.0	-0.8	-1.1	-1.5	-1.7	-1.8
Impedance of whole body	0.3	1.6	3.4	1.6	-0.6	1.8	0.9	0.6	1.0	1.7	1.5	1.0	1.8	1.4	0.9	0.6
Leg fat mass (left)	0.1	0.5	1.6	1.0	1.1	-0.1	0.1	0.1	0.3	0.4	0.3	-0.2	0.8	1.3	0.6	1.0
Arm predicted mass (left)	0.2	0.9	2.0	1.4	0.4	0.1	1.0	0.8	0.9	0.6	0.8	0.5	1.1	1.0	1.3	1.4