Hub : Genes

ACER3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.1270	0.0550	7.5e-03	-0.002	NA	-0.005	NA	0.002	4.6e-01	NA	8.2e-01	NA	2.4e-01
2	GTEx	Esophagus Mucosa	0.0940	0.0350	4.4e-04	0.044	NA	0.011	NA	0.031	6.0e-04	NA	5.4e-02	NA	3.4e-03
3	GTEx	Testis	0.3290	0.0950	3.2e-03	0.233	NA	0.208	NA	0.219	1.1e-10	NA	1.3e-09	NA	4.6e-10
4	METSIM	Adipose	0.2319	0.0368	0.0e+00	0.209	0.219	0.275	0.260	0.279	1.2e-30	3.6e-32	3.7e-41	1.2e-38	5.8e-42
5	ROSMAP	Brain Pre-frontal Cortex	0.3019	0.0512	0.0e+00	0.278	0.233	0.290	0.266	0.280	6.5e-36	1.7e-29	1.2e-37	3.8e-34	3.8e-36
6	YFS	Blood	0.0626	0.0164	3.9e-13	0.028	0.043	0.035	0.043	0.041	1.1e-09	5.1e-14	1.1e-11	5.6e-14	2.3e-13
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.1406	0.0516	5.6e-07	0.074	0.079	0.083	NA	0.081	1.0e-08	3.3e-09	1.3e-09	NA	1.9e-09
8	TCGA	Ovarian Serous Cystadenocarcinoma	0.0770	0.0580	4.3e-04	0.047	0.050	0.057	NA	0.036	3.9e-04	2.5e-04	1.0e-04	NA	1.7e-03
9	TCGA	Pancreatic Adenocarcinoma	0.3190	0.1390	7.9e-04	0.091	0.075	0.049	NA	0.066	1.2e-04	4.5e-04	4.0e-03	NA	1.0e-03
10	TCGA	Prostate Adenocarcinoma	0.2243	0.0623	0.0e+00	0.200	0.200	0.202	NA	0.202	1.5e-20	1.6e-20	8.8e-21	NA	1.0e-20

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.8	1.2	3.6	-0.8	1.1	1.1	0.3	1.3	1.4	1.9	0.9	0.9	0.4
Bipolar Disorder or Schizophrenia	0.6	1.5	3.3	0.3	1.7	1.3	0.0	1.8	0.8	1.8	1.5	0.7	0.2
Depressed Affect (Nagel 2018)	0.3	0.7	1.3	1.1	-0.4	0.6	0.9	-0.8	-0.4	1.1	0.5	1.2	1.0
Depression (Nagel 2018)	0.8	1.2	2.9	0.7	-0.3	0.1	1.2	-0.3	-1.4	1.6	-0.4	1.7	1.6
Intelligence (Savage-Jansen 2018)	2.0	6.3	15.7	0.4	-4.0	-0.0	3.6	-2.6	-3.5	-1.2	-1.7	1.8	2.8
Neuroticism (Nagel 2018)	0.7	1.8	3.4	0.6	-0.5	1.2	1.6	-0.9	-1.6	1.6	-0.6	1.7	1.8
Schizophrenia (2018)	0.3	0.7	1.8	1.0	1.3	0.8	-0.2	1.3	-0.1	0.7	1.1	0.2	-0.2
Schizophrenia vs Biploar Disorder	0.2	0.3	1.2	1.1	-0.0	0.3	-0.3	0.1	-0.8	-0.0	-0.9	-0.4	0.1
Worry (Nagel 2018)	0.6	1.2	5.4	-0.2	-0.6	-0.2	0.5	-1.5	-2.3	0.1	-1.8	0.2	0.7
Alzheimer’s Disease (in mother)	0.5	0.6	1.7	0.7	1.1	0.1	-0.1	0.5	0.7	0.3	1.3	1.1	0.4
Alzheimer’s Disease (in father)	0.2	0.2	0.7	0.2	0.2	0.3	0.8	-0.3	-0.6	0.2	-0.5	0.7	0.6
Alzheimer’s Disease (including proxy)	0.6	0.9	2.2	0.8	1.4	0.7	-0.1	0.7	0.9	0.9	1.5	1.1	0.3
Crohns Disease (2017)	0.5	1.1	2.7	1.5	1.1	0.9	-0.5	1.5	-0.1	0.1	1.6	-0.8	-1.0
Irritable Bowel Disease (IBD)	0.8	2.0	6.0	-0.1	2.0	1.3	-1.1	2.5	0.7	1.0	1.9	-0.6	-1.1
Ulcerative Colitis (UC)	1.5	2.7	7.6	-1.3	2.1	1.5	-1.2	2.7	1.5	1.8	2.0	-0.0	-0.9
Major Depression (MDD)	2.0	2.4	5.9	1.5	0.9	1.9	0.8	1.2	2.3	2.4	1.1	1.4	1.0
Reaction Time	0.4	0.7	4.2	2.0	0.5	-0.4	-0.8	0.8	-0.8	0.5	-0.5	-0.1	-0.3
Verbal and Numeric Reasoning (VNR)	3.3	7.9	16.2	0.2	-4.0	1.1	3.8	-3.0	-3.4	-0.4	-2.6	2.5	3.6
Breast Cancer	0.2	0.4	1.1	1.0	0.1	0.6	1.1	-0.5	0.8	0.3	0.2	0.3	0.6
Ovarian Cancer	0.2	0.2	0.8	-0.1	0.6	-0.9	-0.0	0.1	0.3	-0.9	0.3	-0.0	-0.4
Prostate Cancer	0.1	0.2	0.7	-0.1	-0.5	-0.1	-0.5	-0.6	-0.5	-0.3	-0.8	-0.4	-0.2
Age at First Birth	0.2	0.3	2.3	-1.5	0.4	-0.1	0.6	0.2	-0.2	0.0	-0.1	0.4	0.3
Bipolar Disorder (2011)	2.8	2.7	7.6	-1.2	1.5	2.8	0.0	1.7	1.1	2.6	1.8	1.4	0.6
Body Mass Index (BMI) (2010)	0.2	0.3	0.6	0.8	0.6	-0.2	0.4	0.3	0.8	0.2	0.4	0.6	0.3
Coronary Artery Disease (CAD)	1.0	1.3	2.5	1.4	-1.2	-1.6	0.7	-1.4	-1.1	-1.6	-0.8	0.2	0.2
Crohns Disease (2012)	0.4	0.7	3.0	1.1	0.4	1.1	0.6	0.7	0.8	0.2	1.7	-0.0	-0.1
Mean Putamen Volume	0.3	0.3	1.0	-1.0	0.4	-0.4	-0.7	0.5	-0.5	0.5	-0.2	-0.3	-0.4
Fasting Glucose	0.3	0.4	1.2	-0.1	-0.1	1.1	0.3	0.4	0.3	-0.4	0.7	1.1	0.6
HbA1C	0.9	1.0	2.2	-1.5	1.2	-1.2	-0.4	0.5	0.5	-0.4	1.0	-0.9	-1.5
HDL Cholesterol	0.9	1.6	4.3	-1.8	-1.4	-0.4	0.8	-1.7	-2.1	-0.7	-1.0	0.3	0.8
LDL Cholesterol	0.5	0.8	1.5	1.1	0.3	1.2	1.0	0.5	0.4	0.9	1.2	1.2	0.6
Lupus	0.1	0.2	0.5	-0.4	-0.1	-0.1	-0.1	-0.4	-0.5	-0.4	-0.7	-0.6	-0.2
Neuroticism (2016)	0.6	0.9	4.2	0.4	0.7	0.9	-0.9	1.2	0.7	2.1	0.8	0.4	-0.0
Primary Biliary Cirrhosis	0.5	0.7	1.6	-0.6	0.3	0.9	0.4	1.1	-0.1	1.2	-0.2	1.3	1.1
Rheumatoid Arthritis	2.0	2.7	7.3	-0.2	-2.0	-0.4	1.7	-2.5	-1.4	-0.7	-2.7	1.0	1.8
Schizophrenia (2014)	0.9	2.1	5.5	1.2	1.7	2.1	0.0	2.0	0.5	2.4	1.2	0.8	0.5
Triglycerides	0.2	0.4	1.4	0.9	-0.2	-0.7	0.3	-0.5	-0.5	-1.2	-0.4	0.2	0.2
Type 2 Diabetes (T2D) (2012)	0.2	0.2	1.3	-1.1	0.1	-0.1	0.1	0.1	0.4	0.4	0.5	0.5	0.3
Ulcerative Colitis	1.1	1.5	4.0	-2.0	1.0	1.9	-0.4	1.5	0.5	1.4	1.1	0.8	0.2
Blood Eosinophil Count	0.5	3.9	28.2	5.3	-1.5	-1.0	-0.3	-1.2	-1.7	-0.5	-1.4	-0.8	-0.2
Blood Platelet Count	0.4	4.8	44.1	6.6	-0.4	-0.0	0.9	-0.2	0.1	-0.1	1.7	0.2	-0.1
Blood Red Count	0.3	2.7	5.6	-1.9	1.3	-1.6	-1.9	0.4	1.3	-1.7	1.6	-1.7	-2.4
Blood White Count	0.8	6.2	16.0	2.8	-0.1	-4.0	-2.0	-1.7	-0.3	-3.8	-1.2	-2.9	-2.5
Heel T-Score	0.9	7.1	16.9	-1.8	2.7	-2.5	-3.8	2.3	1.1	-0.6	2.1	-3.4	-4.1
BMI	0.2	1.1	3.3	1.1	-0.5	-1.6	1.0	-1.0	1.0	-1.8	0.3	0.5	0.1
Height	0.1	1.4	7.8	-2.8	-0.1	-1.6	-0.4	-0.8	-0.8	-1.1	-0.9	-0.5	-0.3
Waist Hip Ratio (WHR)	0.1	0.5	2.3	0.0	0.6	1.5	0.4	-0.1	-0.5	0.9	-0.2	0.4	0.6
Systolic Blood Pressure	1.7	8.4	19.8	2.3	3.0	2.6	-0.2	4.3	3.0	4.5	3.6	1.7	0.5
Smoking Status	0.1	0.3	0.9	0.1	-0.3	-0.4	-0.8	-0.4	0.9	-0.1	-0.6	-0.9	-0.6
Allergy or Eczema	0.8	2.1	7.4	2.7	-0.6	2.6	0.7	-0.1	-1.0	1.4	0.6	1.1	1.2
Cardiovascular Disease	0.6	2.1	5.3	2.3	1.2	-0.6	-2.1	1.3	1.6	-0.6	1.4	-0.8	-1.7
Hypothyroidism (self reported)	0.9	2.0	11.4	3.4	-1.7	-0.3	1.1	-1.2	0.1	-0.8	-0.8	0.7	0.9
Respiratory disease	0.8	1.8	9.7	3.1	1.6	0.8	-0.6	1.3	0.3	0.5	1.5	-0.1	-0.7
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.5	0.9	0.2	-0.9	-1.0	-0.2	0.5	-0.4	-0.4	-1.2	-1.1
Lung FEV1/FVC ratio	0.9	4.5	12.0	1.1	3.5	-0.6	-2.0	2.9	2.8	0.3	2.0	-1.4	-2.2
Lung FVC	0.2	0.9	3.3	-1.8	-0.8	-0.4	-1.5	-0.0	0.6	-0.3	0.1	-1.1	-1.1
Neuroticism	0.5	1.2	3.0	-0.5	0.5	1.3	0.7	-0.1	-1.3	1.6	0.0	1.7	1.4
Chronotype (morning person)	0.4	0.8	2.1	1.4	0.2	-0.8	-1.1	0.4	0.6	-0.7	-0.2	-1.4	-1.2
Hair Pigment	0.0	1.0	3.4	-1.0	0.3	-1.9	-0.8	-0.2	-1.0	-1.6	-0.1	-0.9	-1.0
Tanning	0.0	0.6	1.7	0.2	-0.7	1.1	1.1	-0.5	-0.2	0.4	-1.3	0.0	0.9
Hand grip strength (left)	0.4	1.2	3.0	1.7	0.4	-1.7	-1.0	0.1	1.6	-1.0	0.4	-0.3	-0.9
Number of treatments/medications taken	1.1	2.0	5.3	2.3	1.7	0.8	-1.7	1.4	2.1	0.1	0.8	-0.3	-0.9
Average weekly spirits intake	0.3	0.4	1.4	0.5	1.2	-0.4	-0.5	0.7	1.1	-0.1	0.6	0.1	-0.4
Sensitivity / hurt feelings	0.1	0.2	0.6	-0.6	0.5	-0.3	-0.2	-0.2	-0.3	0.1	-0.7	0.3	0.2
Frequency of depressed mood in last 2 weeks	0.3	0.5	2.8	0.1	0.7	0.3	0.2	0.2	-0.3	1.7	0.4	0.8	0.4
Hearing difficulty/problems: Yes	0.1	0.1	0.4	0.5	-0.3	-0.7	-0.5	0.2	-0.3	-0.1	-0.1	-0.0	-0.1
Relative age of first facial hair	1.0	2.0	5.5	-0.5	1.1	-1.7	-2.3	1.1	0.3	-1.0	1.6	-1.2	-2.0
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.5	-0.7	-0.8	-0.6	-0.6	-1.1	-0.1	-1.6	-0.7	-1.2	-0.7
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.6	0.1	0.5	-0.0	-0.7	-0.6	0.6	-0.4	-0.4	-0.2	-0.4
Ever had hysterectomy (womb removed)	0.4	0.4	1.2	0.1	0.5	0.6	-0.1	0.7	1.1	1.0	0.4	0.5	0.2
Systolic blood pressure, automated reading	2.4	7.0	15.9	2.3	2.8	1.8	-0.6	4.0	2.6	3.7	3.9	1.1	-0.2
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.2	-0.4	-0.7	-0.8	-0.0	-1.1	-1.0	-0.8	-1.1	-0.2	0.1
Angina	0.3	0.4	1.8	-0.6	0.4	-0.2	-1.3	-0.0	0.3	0.4	-0.9	-0.4	-0.4
Medication for hormone replacement therapy	0.3	0.3	1.0	-1.0	0.8	0.6	0.0	0.3	0.2	0.5	0.9	0.1	-0.1
Vitamin and mineral supplements	0.5	0.7	1.5	0.3	-0.9	-0.2	1.1	-1.2	-0.8	-0.0	0.0	1.1	1.1
Supplements: Zinc	1.0	1.1	2.8	0.5	0.9	-0.9	-0.7	0.8	1.7	-0.7	1.4	-1.1	-1.4
Medication: Co-codamol	0.5	0.6	1.8	0.7	-0.8	0.4	0.2	-0.0	0.3	0.6	-1.0	1.4	1.2
Medication: Metformin	1.2	1.8	4.7	0.7	-0.0	-2.2	-1.0	-0.7	-0.5	-2.2	-1.1	-1.7	-1.4
Diabetes (father)	0.9	1.1	3.5	-0.6	-0.9	-1.3	-0.4	-0.6	-0.3	-1.9	-0.4	-1.5	-1.2
Diabetes (mother)	0.3	0.4	1.4	-1.2	-0.7	0.1	0.7	-0.9	0.6	0.1	-0.2	0.1	0.4
Severe depression (siblings)	0.6	0.7	4.5	0.8	0.3	-0.0	-0.4	0.6	0.5	-0.2	2.1	-0.0	-0.8
Pack years adult smoking proportion	0.4	0.6	3.0	1.7	0.4	0.1	-0.7	0.2	0.8	0.7	-0.3	-0.8	-0.7
Impedance of leg (right)	0.2	1.0	2.4	0.8	0.3	1.1	1.2	-0.3	-1.2	0.8	-0.6	1.4	1.6
Leg fat-free mass (left)	0.1	0.6	2.0	0.3	-0.1	-1.4	-0.7	-0.4	1.0	-1.1	0.3	-0.6	-0.8
Trunk fat percentage	0.3	1.1	5.2	2.3	0.1	-0.5	1.2	-1.2	0.4	-0.9	-0.3	0.9	0.9
Hand grip strength (right)	0.6	1.6	4.4	1.1	1.0	-1.4	-1.3	0.7	2.1	-1.1	1.5	-0.6	-1.5
Townsend deprivation index at recruitment	0.1	0.1	0.4	-0.3	-0.4	0.2	0.2	0.0	-0.6	-0.2	0.4	0.1	0.0
Current tobacco smoking	0.9	1.5	4.5	-0.1	0.8	-1.1	-1.8	1.0	2.1	-0.2	0.1	-1.4	-1.6
Average weekly fortified wine intake	0.8	0.9	3.1	0.6	-1.8	-0.5	1.1	-1.2	-0.8	-0.7	-0.8	0.3	0.8
Maternal smoking around birth	0.4	0.6	1.5	0.5	0.8	-0.4	-1.1	0.1	0.4	-0.4	-1.2	-1.1	-0.8
Fed-up feelings	0.1	0.2	0.7	0.5	0.8	0.4	-0.1	-0.2	0.3	0.5	-0.2	0.2	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	2.1	1.4	0.2	0.0	-0.0	-0.0	-0.5	0.3	-0.7	0.4	0.3
Relative age voice broke	0.5	0.8	3.0	-0.8	1.0	-0.8	-1.0	0.9	0.4	0.1	1.7	0.1	-0.7
Taking other prescription medications	0.6	0.9	7.3	2.7	0.4	0.2	-0.8	-0.2	-0.0	-0.7	-0.2	0.0	-0.2
Age when periods started (menarche)	0.7	1.8	6.7	0.7	0.7	2.6	0.7	0.9	-0.1	1.7	0.5	1.9	1.5
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.7	1.1	-1.3	-0.4	0.5	-1.1	-0.1	-0.2	-1.1	-0.5	0.3
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	6.8	-0.9	-0.1	-1.1	-1.9	0.3	0.5	-0.8	1.4	-2.6	-2.5
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.5	1.2	-0.6	-0.3	-0.2	-1.0	1.0	-1.1	-0.3	0.2	0.1
Qualifications: CSEs or equivalent	1.6	2.1	4.8	-0.3	-2.0	-1.8	-0.1	-1.6	-0.4	-2.2	-1.6	-1.6	-0.7
Serious illness, injury or assault to yourself	2.4	2.9	9.1	-0.7	1.5	-1.7	-3.0	0.7	0.8	-0.4	0.7	-2.4	-2.6
High blood pressure	1.2	3.5	7.7	2.8	1.7	0.3	-2.6	1.5	1.7	-0.5	2.1	-1.5	-2.3
Hayfever, allergic rhinitis or eczema	0.9	2.1	7.6	2.8	-1.6	2.1	1.0	-1.0	-1.4	0.3	0.4	0.8	1.0
Multivitamins +/- minerals	0.5	0.6	1.7	-0.8	1.3	0.7	-0.5	1.3	0.1	1.0	0.6	0.1	-0.3
Stomach or abdominal pain in last month	1.1	1.3	3.6	-0.1	1.4	0.6	-1.5	1.1	1.6	1.9	0.2	-0.8	-0.8
Supplements: Glucosamine	0.7	0.9	2.8	-0.3	1.6	0.9	-0.9	1.7	0.5	0.7	0.9	-0.5	-0.8
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	4.0	0.9	1.4	1.2	-0.1	1.4	2.0	1.9	1.1	1.3	0.5
Medication: Atenolol	3.7	4.7	11.4	1.4	2.6	2.0	-0.9	2.4	2.7	3.4	2.6	1.2	-0.1
Medication: Levothyroxine sodium	0.4	0.7	1.9	1.0	-1.4	-1.0	1.0	-0.8	-0.5	-0.7	-0.2	0.2	0.3
Sitting height	0.0	0.3	1.5	-1.2	-0.6	-0.3	-0.4	-0.3	0.6	0.1	-0.0	0.2	0.2
Chronic bronchitis/emphysema (father)	0.4	0.5	3.4	1.9	-0.2	-0.1	-0.7	-0.4	-0.1	-0.1	-0.7	0.4	0.1
High blood pressure (mother)	0.5	0.7	1.9	0.9	0.8	0.2	-0.8	0.7	0.5	0.1	1.4	-0.8	-1.2
Body mass index (BMI)	0.2	0.9	3.1	1.8	0.4	-1.4	0.2	-0.5	1.0	-1.2	0.6	-0.1	-0.5
Impedance of leg (left)	0.1	0.7	1.9	1.4	0.3	0.5	1.0	-0.4	-0.9	0.4	-0.8	0.9	1.1
Leg predicted mass (left)	0.1	0.6	2.0	0.2	-0.1	-1.4	-0.6	-0.4	1.0	-1.0	0.3	-0.6	-0.8
Trunk fat mass	0.2	0.8	3.1	1.8	0.0	-0.9	0.8	-1.1	0.6	-1.1	-0.2	0.7	0.5
Waist circumference	0.1	0.5	2.5	1.6	0.4	-0.2	0.6	-0.5	0.5	-0.2	0.3	0.9	0.5
Number of incorrect matches in round	1.0	1.7	4.7	-0.7	1.5	0.9	0.9	1.7	0.2	1.6	1.2	2.2	1.1
Past tobacco smoking	0.4	0.8	2.8	0.1	1.2	-0.5	-0.5	1.7	0.9	0.4	1.3	-0.1	-0.7
Alcohol usually taken with meals	0.5	0.8	1.8	-1.2	-1.1	0.2	1.3	-0.5	-0.5	-0.2	-1.1	0.7	1.1
Nervous feelings	0.5	1.0	3.1	1.1	0.5	0.4	0.4	-0.6	-1.1	1.3	-1.8	0.9	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.7	0.0	0.6	1.2	0.3	0.8	-0.4	1.3	0.4	1.0	0.7
Hearing difficulty/problems with background noise	0.3	0.5	1.8	0.2	-0.4	-0.9	-0.9	-0.2	0.2	-1.4	-0.5	-0.7	-0.7
Hair/balding pattern: Pattern 2	1.8	2.3	5.4	1.6	1.5	0.8	0.3	1.0	2.3	2.3	1.7	1.5	0.6
Had menopause	2.0	2.5	5.9	-1.3	-1.1	1.7	1.6	-0.8	-1.7	0.7	-0.9	2.4	2.4
Had other major operations	0.5	0.6	5.7	-2.4	-0.2	0.1	-0.0	0.4	-0.3	0.2	-0.2	0.3	0.4
Forced vital capacity (FVC)	0.2	0.7	4.1	-2.0	-0.7	-0.8	-0.6	0.4	0.8	-0.5	0.5	-0.5	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	4.2	-0.7	1.1	-0.9	-2.0	1.5	0.6	0.5	1.5	-1.5	-2.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.6	-0.2	-0.4	-0.7	-1.0	-0.8	-0.3	-0.7	-1.2	-1.2	-0.6
Qualifications: None of the above	0.8	1.7	6.6	2.6	1.5	1.1	-0.8	1.1	1.6	1.4	0.6	0.1	-0.3
Financial difficulties in last 2 years	0.3	0.4	1.4	-0.8	0.4	-0.5	-1.2	0.6	-0.3	0.3	-0.2	-0.9	-0.8
Mouth/teeth dental problems	0.5	0.8	3.4	-1.9	-0.8	0.4	-0.1	0.4	1.7	0.6	0.5	0.1	-0.0
Heart attack	0.8	1.1	2.4	1.6	-1.1	1.2	0.7	-0.9	0.0	0.9	-1.3	0.7	1.1
Allergy	1.0	2.3	14.7	-3.8	0.9	-1.9	-0.8	0.3	0.7	-0.6	-1.1	-0.5	-0.5
Pain all over the body in last month	0.3	0.3	1.2	1.1	-0.4	0.3	0.1	-0.4	0.5	0.7	-0.8	-0.4	0.0
Diabetes (self-reported)	0.4	0.6	4.9	2.2	0.4	-0.1	-0.4	-0.1	-0.1	-0.1	-1.0	0.3	0.2
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	6.1	2.5	0.1	1.9	0.3	1.1	0.6	1.6	1.7	1.3	0.7
Medication: Ramipril	0.3	0.3	1.2	-0.8	0.8	1.1	-0.1	0.4	0.3	0.5	0.1	0.5	0.1
Medication: Simvastatin	0.6	0.9	3.2	0.0	-0.8	-1.0	-0.5	-1.1	-0.2	-1.5	-1.8	-0.3	-0.1
Fluid intelligence score	3.2	6.7	13.6	-0.6	-3.7	1.3	3.5	-3.0	-2.6	-0.2	-2.3	2.3	3.5
Illnesses of siblings	0.8	1.1	2.8	-1.1	-1.3	-0.6	0.1	-1.7	-1.5	-1.3	-0.9	-0.6	0.0
Neuroticism score	0.2	0.3	0.9	-0.3	0.5	0.7	-0.3	-0.3	-1.0	0.9	0.1	0.5	0.3
Weight	0.1	0.6	2.0	1.1	-0.0	-1.4	0.2	-0.8	0.9	-1.1	0.1	0.3	-0.0
Impedance of arm (right)	0.5	2.5	5.1	0.3	-1.4	1.4	1.9	-1.4	-2.3	0.2	-1.9	1.5	2.2
Arm fat percentage (right)	0.2	0.9	4.1	2.0	0.1	-0.7	1.0	-0.8	0.5	-1.2	0.1	0.9	0.6
Trunk fat-free mass	0.1	0.8	2.4	-0.1	0.1	-1.6	-1.0	0.3	1.4	-0.6	0.4	-0.7	-1.0
Hip circumference	0.3	1.2	5.0	2.2	-0.3	-1.0	1.1	-0.9	1.0	-0.9	0.2	1.3	0.9
Time employed in main current job	1.0	1.1	2.8	-0.0	1.4	0.9	-0.9	0.8	1.4	0.1	1.7	-0.9	-1.2
Alcohol intake versus 10 years previously	0.8	1.2	4.3	0.1	0.0	-1.7	-1.3	0.1	0.0	-0.4	0.1	-2.1	-1.7
Father’s age at death	0.2	0.3	2.1	-1.4	0.4	-0.5	-0.4	-0.3	-0.4	-0.2	-0.5	0.2	0.2
Worrier / anxious feelings	0.2	0.4	1.1	-0.7	-0.4	-0.2	-0.0	-1.0	-0.9	0.7	-0.6	0.6	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	2.9	1.7	-0.1	1.1	0.5	-0.3	0.4	0.2	-0.5	0.3	0.7
Falls in the last year	0.2	0.3	1.2	-1.1	-0.5	-0.3	-0.1	-0.4	-0.7	-0.3	-0.4	0.0	0.3
Hair/balding pattern: Pattern 3	2.0	2.9	7.0	-1.8	-1.9	0.2	1.5	-2.0	-2.3	-1.1	-2.6	0.8	1.5
Number of live births	0.3	0.4	1.2	1.1	-1.1	-0.5	-0.1	-0.6	0.3	-0.6	0.2	-0.4	-0.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	2.0	-1.2	0.2	-0.5	-0.7	1.2	1.1	0.1	1.4	-0.3	-0.7
Pulse rate	1.6	2.7	5.2	2.1	1.1	-2.3	-1.6	0.8	1.1	-1.2	1.2	-1.9	-2.3
Happiness	1.1	1.3	7.0	0.2	-0.1	-0.4	0.6	-0.8	-1.3	0.6	-2.6	0.9	1.5
Noisy workplace	1.8	2.2	3.9	1.7	1.0	-2.0	-1.3	0.5	1.0	-2.0	1.5	-1.2	-1.9
Qualifications: A levels/AS levels or equivalent	0.7	1.5	3.6	-0.6	-1.9	-0.7	1.0	-1.8	-1.8	-1.7	-0.7	-0.1	0.5
Serious illness, injury or assault of a close relative in last 2 years	1.7	2.0	10.6	0.1	2.1	0.4	0.9	1.4	0.8	0.7	3.3	0.9	-0.1
Mouth/teeth dental problems: Dentures	0.2	0.3	1.3	1.2	0.2	-0.6	-0.1	-0.8	-0.3	-0.8	-0.2	-0.5	-0.3
Asthma	1.3	2.6	13.1	3.6	1.8	0.7	-1.0	1.8	0.8	1.1	1.6	0.1	-0.7
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.4	8.6	1.4	1.6	0.7	-1.8	1.7	2.9	1.2	1.4	-0.5	-1.1
Medication: Cholesterol lowering	0.1	0.2	0.9	0.6	-0.4	-0.1	-0.6	-0.5	-0.3	-0.3	-1.0	-0.0	-0.0
Depression (self-reported)	1.0	1.2	4.0	0.3	-1.3	-0.6	0.3	-1.6	-1.2	-1.1	-2.0	-0.3	0.3
Medication: Lansoprazole	0.3	0.4	1.0	0.9	-0.4	-0.1	0.6	-1.0	-0.9	0.2	-0.8	-0.1	0.4
Prospective memory result	0.3	0.3	1.0	0.3	0.8	0.5	-0.2	0.7	1.0	0.8	-0.1	0.4	0.2
Lung cancer (father)	0.9	1.1	3.5	1.4	0.9	1.6	0.1	0.8	0.0	1.9	-0.2	0.8	0.6
Illnesses of mother	0.7	0.9	4.2	-0.8	-0.4	-0.9	-0.7	-0.6	-1.4	-0.6	-2.0	-0.5	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.4	-0.8	-0.1	-0.1	-0.3	0.7	1.2	0.7	1.1	-0.0	-0.3
Pulse wave Arterial Stiffness index	0.1	0.1	0.5	-0.4	0.1	0.0	0.2	0.3	-0.2	0.2	-0.7	0.0	0.0
Impedance of arm (left)	0.6	2.6	5.5	-0.3	-1.5	1.2	1.8	-1.4	-2.4	0.2	-2.1	1.4	2.2
Arm fat mass (right)	0.2	0.9	3.6	1.9	0.1	-1.3	0.5	-0.9	0.8	-1.4	0.2	0.3	0.1
Trunk predicted mass	0.1	0.8	2.7	-0.1	0.1	-1.6	-1.0	0.3	1.4	-0.6	0.4	-0.8	-1.1
Standing height	0.1	0.6	1.6	-1.1	-1.0	-0.5	-0.0	-1.0	-0.2	-0.4	-1.3	0.5	0.8
Length of working week for main job	0.6	0.7	2.5	-1.6	0.2	-1.2	0.6	0.2	0.5	-0.7	1.2	0.7	-0.0
Exposure to tobacco smoke at home	0.4	0.4	1.6	-0.0	-0.6	-0.7	0.4	-0.6	-0.9	0.1	-1.3	0.1	0.6
Breastfed as a baby	0.7	0.8	2.2	-0.6	1.5	0.1	-0.7	1.5	1.1	0.6	1.1	0.1	-0.4
Tense / ‘highly strung’	1.4	2.3	5.3	0.7	-0.9	0.8	2.0	-1.2	-1.5	0.6	-2.3	1.6	2.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.8	-0.1	0.3	0.3	0.4	0.3	0.9	0.8	-0.0	0.8	0.7
Hair/balding pattern: Pattern 4	0.6	1.5	3.3	-1.8	0.9	-0.6	-1.0	1.1	0.8	-0.8	1.8	-1.2	-1.5
Birth weight of first child	1.4	2.5	7.4	-1.7	1.1	-1.4	-2.7	0.6	0.4	-0.7	0.2	-2.3	-2.3
Peak expiratory flow (PEF)	0.5	1.1	3.5	0.2	1.0	0.6	-1.1	1.6	1.9	0.9	1.1	-0.1	-0.6
Pulse wave reflection index	0.7	0.8	3.5	-1.9	0.4	1.1	0.3	0.9	-0.1	1.4	0.1	0.5	0.5
Ever highly irritable/argumentative for 2 days	0.5	0.5	2.9	0.1	0.4	-0.1	-0.2	-0.5	-0.4	0.3	-1.7	1.1	0.8
Loud music exposure frequency	1.3	1.4	3.3	-0.4	-0.7	-1.1	0.8	-1.4	-1.7	-0.9	-1.8	1.1	1.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.8	-0.6	-0.1	-0.0	0.3	0.3	0.5	0.3	0.9	0.1	0.1
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	2.2	1.5	1.0	1.1	1.0	0.5	-1.2	0.9	0.4	1.2	1.1
Blood clot in the leg (DVT)	0.3	0.4	1.1	-0.1	-0.9	0.3	0.3	-0.6	0.3	-0.6	1.1	-0.4	-0.5
Medication: Paracetamol	1.4	2.3	4.0	2.0	1.9	1.2	-1.3	1.9	1.9	1.4	1.7	0.3	-0.6
Headache pain in last month	0.4	0.6	2.2	1.5	-0.5	-0.0	-0.6	-0.2	1.2	-1.0	0.2	-0.7	-0.5
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.9	-0.3	-0.2	0.1	0.7	0.4	0.1	1.0	0.0	-0.2	0.2
Glaucoma (self-reported)	1.6	1.9	4.8	-0.0	-0.2	-2.2	-1.2	-0.6	-1.3	-2.1	-1.3	-1.7	-1.4
Gout (self-reported)	0.2	0.2	0.7	0.3	0.2	-0.8	-0.8	-0.0	0.2	-0.5	0.0	-0.4	-0.6
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	4.3	2.1	-1.3	-0.5	0.7	-0.5	-0.3	-0.7	-0.4	0.3	0.5
Medication: Amlodipine	1.3	1.9	3.6	1.7	1.5	-0.3	-1.6	1.0	1.3	-0.9	1.2	-1.6	-1.9
Medication: Ventolin 100micrograms inhaler	1.7	2.2	5.0	-0.1	2.1	1.9	-0.3	2.2	1.0	1.7	1.9	0.9	0.1
Birth weight	0.4	0.9	2.1	-1.5	0.9	-0.2	-1.3	1.0	1.1	-0.1	0.4	-1.0	-1.2
Chronic bronchitis/emphysema (mother)	0.5	0.6	2.1	-0.4	-0.9	-0.2	0.7	-1.5	-0.8	-0.7	-0.8	0.5	0.6
High blood pressure (siblings)	0.7	1.0	3.3	-0.7	1.8	-1.1	-1.0	1.3	0.7	0.1	0.8	-0.4	-0.9
Forced vital capacity (FVC), Best measure	0.1	0.3	1.8	-1.3	-0.7	-0.2	-0.3	0.1	0.6	0.5	0.2	0.0	0.1
Body fat percentage	0.3	1.2	5.3	2.3	-0.0	-0.7	1.4	-1.2	0.3	-1.1	-0.2	1.1	0.9
Leg fat percentage (right)	0.3	1.1	5.1	2.2	0.6	-0.9	1.1	-0.7	0.5	-1.1	0.5	1.2	0.6
Arm fat-free mass (right)	0.2	1.3	3.3	0.5	0.5	-1.6	-1.3	0.3	1.8	-0.7	0.8	-1.1	-1.4
Exposure to tobacco smoke outside home	0.6	0.9	2.5	-0.2	0.5	-1.1	-1.5	-0.0	0.4	-0.7	0.2	-1.2	-1.6
Comparative body size at age 10	0.3	0.9	4.7	-0.4	-0.2	-2.2	-0.5	-0.7	-0.0	-1.4	0.5	-0.6	-1.0
Number of full brothers	0.4	0.5	2.4	0.8	-0.7	1.5	0.8	0.6	-0.2	0.7	0.3	0.1	0.5
Worry too long after embarrassment	0.5	0.9	3.7	0.0	-0.5	1.0	0.7	-0.4	-1.9	0.6	-0.0	1.2	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.7	0.3	-0.6	-0.0	1.6	-1.1	-1.4	-0.4	-0.8	1.0	1.2
Wheeze or whistling in the chest in last year	0.3	0.5	1.7	1.3	0.7	0.4	-0.4	1.0	0.7	0.7	0.2	0.8	0.1
Number of children fathered	0.5	0.6	4.9	-2.2	-0.0	0.5	0.0	-0.4	0.0	0.0	-0.3	0.6	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.1	-0.6	-0.5	1.4	1.2	-0.4	-0.3	-0.0	0.2	1.3	1.1
Age at first live birth	0.5	0.8	2.7	-1.3	0.7	-0.8	-0.6	-0.2	-1.6	0.4	-1.3	-0.5	-0.2
Pulse wave peak to peak time	0.1	0.1	0.4	0.2	-0.2	-0.1	-0.2	-0.4	0.1	-0.2	0.6	-0.0	-0.0
Health satisfaction	0.7	0.9	2.5	1.6	1.2	-0.7	-1.3	0.6	0.4	-0.5	-0.5	-1.0	-1.0
Shortness of breath walking on level ground	1.3	1.5	4.2	0.2	2.0	-1.8	-1.5	0.7	0.9	-0.8	0.6	-0.7	-1.6
Qualifications: College or University degree	0.3	1.1	2.9	-1.1	-0.5	1.2	1.0	-0.8	-1.7	0.6	-0.4	1.1	1.3
Eye problems/disorders: None of the above	0.7	0.8	2.0	-0.6	0.2	1.4	0.7	0.5	-0.5	1.1	1.4	0.9	0.6
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.1	0.4	0.5	-1.0	-0.1	-0.2	-0.2	-0.8	-1.0	0.6	0.3
Emphysema/chronic bronchitis	0.7	0.8	2.0	1.1	1.2	0.0	-0.3	1.2	1.0	0.6	1.4	0.0	-0.4
Medication for pain relief, constipation, heartburn	2.2	3.7	11.7	-3.4	-1.6	-0.1	1.8	-1.7	-3.0	-0.5	-1.8	1.2	1.8
Neck or shoulder pain in last month	1.3	1.9	5.1	2.3	1.6	1.4	-0.4	1.9	1.4	1.6	0.9	0.3	-0.1
Medication: Blood pressure	0.3	0.6	1.7	0.2	1.3	0.5	-1.0	0.8	1.1	-0.2	0.8	0.2	-0.5
Angina (self-reported)	0.2	0.3	1.2	-0.3	0.3	0.2	-1.1	-0.1	0.2	0.8	-0.9	-0.1	-0.1
Migraine (self-reported)	0.3	0.4	1.0	0.5	-0.1	-0.3	-1.0	-0.7	0.2	-0.9	-0.4	-0.8	-0.8
Medication: Ibuprofen	1.5	1.8	7.6	1.1	1.3	0.8	-1.5	1.2	2.8	1.2	1.1	-0.1	-0.6
Medication: Allopurinol	0.8	1.1	3.5	-0.7	1.9	-1.3	-1.4	0.7	1.0	0.1	0.3	-0.7	-1.2
Medication: Omeprazole	0.5	0.5	1.9	0.7	-0.5	0.3	1.4	-0.9	-0.5	0.4	-0.6	0.5	1.0
Medication: Seretide 50 evohaler	0.3	0.3	2.1	1.5	0.2	0.5	-0.6	0.3	0.6	0.2	0.1	-0.1	-0.2
Mean time to correctly identify matches	0.5	0.9	3.2	1.8	-0.4	-0.7	-0.2	-0.3	-1.6	-0.2	-1.7	0.2	0.4
Heart disease (mother)	0.4	0.4	1.3	0.9	-0.4	0.4	0.2	0.5	1.0	1.1	-0.8	-0.4	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.7	2.7	1.2	0.0	-0.3	0.4	-0.8	0.6	-1.6	-0.6	0.7	0.5
Whole body fat mass	0.2	0.9	3.8	2.0	-0.0	-1.1	0.8	-1.1	0.5	-1.2	-0.1	0.7	0.4
Leg fat mass (right)	0.3	1.0	4.4	2.1	0.3	-1.1	0.8	-0.8	0.6	-1.2	0.2	0.9	0.4
Arm predicted mass (right)	0.2	1.1	2.8	0.3	0.4	-1.6	-1.2	0.2	1.7	-0.6	0.6	-1.0	-1.3
Pulse rate, automated reading	1.2	3.7	7.6	1.3	2.1	-1.6	-2.2	1.5	2.5	-0.8	1.6	-2.3	-2.8
Alcohol intake frequency.	1.0	2.4	4.7	1.9	0.2	-1.4	-1.7	0.7	2.1	-0.3	1.4	-2.0	-2.2
Comparative height size at age 10	0.3	1.7	4.1	-0.7	-1.5	0.5	1.1	-1.2	-1.4	0.3	-2.0	1.2	1.9
Number of full sisters	0.2	0.3	1.7	0.2	0.1	0.3	-0.0	0.5	0.0	0.5	1.3	-0.4	-0.3
Suffer from ‘nerves’	0.4	0.6	2.6	-0.3	-0.0	0.7	-0.2	-0.7	-1.6	-0.3	-1.6	-0.4	0.2
Overall health rating	0.4	0.9	2.9	1.7	0.3	0.7	-1.0	0.2	1.0	0.4	-0.8	-1.3	-0.7
Chest pain or discomfort	0.5	0.7	1.4	-0.4	0.7	-1.1	-1.2	0.4	0.1	-0.7	0.7	-0.9	-1.2
Had major operations	0.4	0.4	1.6	-0.1	-0.8	0.1	0.6	-0.7	0.5	-0.6	-1.3	-0.8	0.2
Age at last live birth	0.3	0.5	1.3	-1.0	0.9	0.2	0.0	0.7	-1.1	0.9	-0.2	0.6	0.4
Family relationship satisfaction	0.8	1.0	2.5	-0.8	0.9	-1.6	-1.5	1.0	0.7	-0.4	-0.1	-0.9	-1.1
Leg pain on walking	1.3	1.6	4.7	2.2	1.4	-0.7	-1.5	0.7	1.9	-0.4	0.0	-0.9	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.9	0.2	-0.6	-1.5	-0.0	-0.6	-0.0	-1.7	-0.1	-0.5	-0.5
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.4	-1.4	0.5	-0.2	0.3	0.9	1.3	0.4	1.6	0.5	0.0
Illness, injury, bereavement, stress in last 2 years	1.2	1.4	2.5	1.3	-1.6	0.4	1.2	-1.6	-0.7	-0.6	-1.4	1.0	1.4
Medication: Aspirin	1.5	2.0	5.3	0.1	-1.1	-2.3	-0.6	-1.1	-0.4	-2.2	-1.1	-2.0	-1.4
Supplements: Vitamin C	0.4	0.4	2.3	0.1	-0.5	0.7	-0.0	0.3	1.5	-0.1	-0.9	0.1	0.4
Knee pain experienced in last month	0.9	1.4	2.8	1.0	1.4	-1.0	-1.6	0.2	1.2	-0.8	-0.8	-1.7	-1.4
Hypertension (Self-reported)	1.2	3.2	7.0	2.6	1.8	0.1	-2.6	1.6	1.5	-0.4	2.1	-1.2	-2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	4.0	0.5	-1.0	-0.1	2.0	-1.3	-0.7	-0.4	-1.4	1.2	1.7
Illnesses of father: Heart disease	1.0	1.3	4.9	1.1	0.1	0.3	-1.0	0.7	1.6	-0.9	2.2	-0.7	-1.2
Illnesses of siblings: Diabetes	0.4	0.5	2.6	1.6	-0.8	-0.4	0.2	-0.9	-0.6	-0.4	-0.3	-0.2	-0.1
Smoking status: Previous	0.3	0.5	1.2	0.2	-0.9	0.9	0.4	-1.1	-0.6	0.4	-0.8	-0.1	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	4.9	-0.7	0.2	-2.2	-1.4	0.1	0.6	-0.8	0.3	-2.1	-2.1
Whole body fat-free mass	0.2	0.9	2.7	0.2	0.1	-1.6	-1.0	0.1	1.4	-0.9	0.4	-0.9	-1.1
Leg fat-free mass (right)	0.2	0.9	2.7	0.2	-0.1	-1.6	-0.9	-0.4	1.1	-1.2	0.2	-1.0	-1.1
Arm fat percentage (left)	0.2	0.8	3.2	1.8	-0.1	-0.7	1.0	-0.8	0.4	-1.2	-0.0	0.9	0.6
Average weekly red wine intake	2.3	3.4	9.4	0.4	-1.3	3.1	2.5	-0.3	-0.1	1.6	-0.0	2.5	2.8
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.1	0.2	0.4	-0.6	-0.6	-0.2	-0.0	-0.2	-1.0	-0.9	-0.7
Mood swings	0.7	1.3	4.2	0.7	1.6	0.6	-0.1	0.9	1.2	2.0	1.2	1.1	0.3
Loneliness, isolation	0.3	0.5	1.4	0.9	-1.1	0.2	0.1	-1.2	-0.9	0.6	0.1	-0.3	-0.0
Long-standing illness, disability or infirmity	0.6	1.0	3.2	1.8	0.3	-0.6	-1.7	0.1	0.8	-0.6	-0.4	-1.0	-1.1
Ever had bowel cancer screening	0.6	0.7	2.2	-1.0	0.2	-0.6	-1.1	-0.4	-0.8	-1.5	-0.6	-0.6	-0.6
Diabetes diagnosed by doctor	0.2	0.4	0.8	0.9	0.3	-0.5	-0.9	-0.2	0.4	-0.8	-0.7	-0.5	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.2	-1.0	0.3	-1.1	-0.7	-0.5	-0.5	-0.9	-0.7	-0.5	-0.4
Friendships satisfaction	0.3	0.3	1.2	-1.1	0.7	-0.3	0.1	0.5	-0.2	0.9	-0.5	0.2	0.4
Qualifications: nursing, teaching	0.3	0.4	1.0	0.3	-0.9	0.0	1.0	-0.7	-0.8	-0.2	-0.5	0.3	0.8
Commuting to job workplace: Walk	0.7	0.8	2.1	1.5	-0.7	1.2	0.6	-0.7	-0.7	0.7	-0.6	0.7	1.0
Eye problems/disorders: Cataract	1.5	1.8	3.4	1.0	0.8	-1.8	-1.6	0.9	1.5	-1.1	0.5	-1.5	-1.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.5	0.3	1.2	0.3	-1.1	0.6	-0.4	0.6	0.4	-0.5	-0.8
Medication for cholesterol	0.4	0.6	1.7	-0.7	-0.1	0.5	1.1	0.4	-0.8	0.7	0.1	1.3	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.2	2.6	4.9	1.8	1.0	-1.1	-1.6	1.5	2.2	-0.7	1.4	-2.0	-2.1
Back pain experienced in last month	0.6	0.9	3.2	1.8	0.7	-0.2	-1.2	0.8	1.1	0.2	-0.6	-1.0	-0.8
Mineral and other dietary supplements	2.3	3.0	6.5	-1.1	-2.4	0.6	2.2	-2.5	-2.0	-0.4	-1.8	0.9	1.9
Breast cancer (self-reported)	0.8	1.0	2.3	-0.8	1.0	-1.3	-1.5	1.4	0.6	-0.1	-0.5	-0.7	-1.0
Asthma (self-reported)	1.1	2.3	12.7	3.6	1.6	0.6	-1.1	1.5	0.6	0.8	1.3	-0.3	-0.9
Osteoporosis (self-reported)	0.2	0.2	1.1	0.9	-0.3	0.1	0.2	-0.4	-1.1	-0.3	0.0	-0.1	0.1
Osteoarthritis (self-reported)	0.3	0.4	1.0	-0.4	0.0	-0.9	-1.0	-0.7	0.4	-0.3	-0.1	-0.9	-0.8
Medication: Aspirin	1.7	2.2	6.2	0.2	-0.9	-2.5	-0.9	-0.9	-0.6	-2.1	-1.2	-2.3	-1.6
Medication: Gliclazide	0.2	0.2	0.5	0.1	0.6	0.6	-0.1	0.5	0.2	0.5	0.1	0.7	0.4
Illnesses of father: None of the above (group 1)	0.5	0.7	2.1	-0.8	1.1	0.9	0.2	0.9	-0.1	1.4	-1.0	-0.2	0.3
Smoking status: Current	0.4	0.6	2.8	-0.0	0.5	-0.7	-1.2	0.5	1.7	-0.1	-0.3	-0.6	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	1.0	-0.6	0.3	0.1	0.4	0.5	0.4	0.3	0.7	1.0	0.5
Whole body water mass	0.1	0.9	2.3	0.3	0.3	-1.5	-1.0	0.2	1.5	-0.7	0.5	-0.8	-1.1
Leg predicted mass (right)	0.2	1.0	3.2	0.2	-0.2	-1.8	-1.0	-0.4	1.1	-1.3	0.2	-1.1	-1.2
Arm fat mass (left)	0.2	0.8	3.0	1.7	0.2	-1.2	0.4	-0.7	1.0	-1.4	0.3	0.4	0.0
Number of self-reported non-cancer illnesses	0.7	1.2	10.1	3.2	-0.7	0.3	-0.2	-0.5	-0.1	-0.9	0.2	0.1	0.0
Average weekly champagne plus white wine intake	1.1	1.6	4.2	-2.0	-0.5	0.2	1.4	-0.3	-1.4	0.2	-2.0	0.9	1.5
Miserableness	0.7	1.3	3.6	1.5	1.0	1.3	0.3	0.5	0.8	1.9	1.1	1.1	0.7
Guilty feelings	0.5	0.8	2.2	-0.6	0.8	1.5	0.4	0.2	-0.8	1.2	0.2	1.3	1.0
Wears glasses or contact lenses	2.5	2.9	6.2	0.2	-2.4	0.1	2.1	-2.5	-1.7	-0.6	-2.1	1.0	1.9
Ever taken oral contraceptive pill	1.0	1.2	3.3	-0.3	0.6	1.8	1.2	0.5	-0.4	1.8	-0.0	1.1	1.2
Hearing aid user	1.1	1.2	3.1	1.8	-1.0	-0.3	1.4	-0.5	-1.2	-0.2	-0.9	1.4	1.3
Mother’s age at death	0.5	0.6	4.2	-2.1	1.2	0.3	-0.4	0.3	-0.5	0.4	-0.1	-0.0	-0.1
Financial situation satisfaction	0.5	0.6	2.4	0.3	0.2	-1.6	-0.8	-0.8	-0.4	-0.3	-1.2	-0.7	-0.4
Tinnitus: Yes, now most or all of the time	0.9	1.1	2.4	0.8	1.6	0.2	-1.2	1.5	1.5	1.0	0.7	-0.1	-0.6
Commuting to job workplace: Public transport	0.9	1.0	3.3	-0.0	0.1	-0.6	-1.8	-0.2	0.5	-0.9	-0.6	-1.6	-1.5
Eye problems/disorders: Glaucoma	1.6	1.9	4.2	0.3	-0.3	-1.8	-1.5	-0.6	-1.3	-2.0	-0.6	-2.0	-1.7
Medication: Blood pressure	0.3	0.7	2.3	1.5	0.3	0.5	-1.2	0.2	1.3	0.0	0.7	-0.2	-0.5
Pain type(s) experienced in last month: Hip pain	1.4	1.7	5.9	1.8	2.4	0.1	-1.2	1.6	1.1	1.0	1.1	0.9	-0.3
Supplements: Fish oil (including cod liver oil)	3.0	3.9	7.9	1.2	1.9	-2.3	-2.5	2.1	1.8	-0.6	1.5	-2.1	-2.8
High cholesterol (Self-reported)	0.4	0.7	2.4	-0.1	-0.8	-1.3	-0.3	-1.1	0.0	-1.5	-0.9	-0.4	-0.4
Medication: Bendroflumethiazide	0.2	0.3	1.3	1.1	0.2	-0.1	-0.8	-0.1	0.8	-0.5	0.4	-0.2	-0.5
Medication: Paracetamol	1.0	1.5	3.0	1.7	1.5	1.0	-0.7	1.4	1.7	1.1	1.2	0.9	0.0
Medication: Lisinopril	1.0	1.3	2.5	1.3	-1.3	-1.4	-0.6	-1.6	0.1	-1.5	-0.9	-1.1	-0.6
Medication: Atorvastatin	1.6	2.0	5.3	0.5	0.9	0.1	-1.5	2.1	2.3	0.9	1.7	-0.9	-1.6
Illnesses of father: High blood pressure	0.4	0.5	2.6	-1.6	0.1	-0.9	-0.0	-0.4	0.3	-0.8	1.0	0.4	-0.1
Alcohol drinker status: Never	1.0	1.2	2.9	1.3	0.3	-0.6	-1.2	0.2	1.2	-1.0	0.7	-1.7	-1.7
Ever smoked	0.4	0.8	2.0	0.2	-0.5	-0.9	-0.7	-1.0	-0.3	-1.1	-1.4	-1.2	-0.6
Basal metabolic rate	0.1	0.8	2.5	0.5	0.1	-1.6	-0.8	-0.1	1.4	-0.9	0.4	-0.6	-0.9
Leg fat percentage (left)	0.4	1.3	6.0	2.5	0.6	-1.4	0.9	-0.7	0.7	-1.5	0.3	0.8	0.3
Arm fat-free mass (left)	0.2	1.3	3.8	1.1	0.9	-1.5	-1.1	0.4	1.9	-0.7	0.9	-0.7	-1.2
Number of operations (self-reported)	0.6	0.9	4.1	-2.0	-0.6	0.3	0.4	-0.4	0.1	-1.6	-0.8	-1.1	-0.2
Average weekly beer plus cider intake	1.1	1.6	3.9	-1.1	1.4	-1.1	-1.5	1.2	0.1	0.3	2.0	-1.0	-1.7
Irritability	1.6	2.8	6.4	-2.5	-0.6	1.0	1.8	-0.4	-2.0	1.2	-1.8	1.8	2.1
Risk taking	0.6	0.8	2.4	-1.6	1.4	0.2	-0.4	1.1	0.7	0.5	0.5	-0.7	-0.8
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.9	-0.7	0.6	-0.8	-0.9	0.8	1.4	-0.0	1.2	-0.9	-1.2
Fractured/broken bones in last 5 years	0.5	0.7	2.2	-0.0	0.3	-1.5	-0.5	0.0	1.1	-0.8	1.0	-0.5	-0.9
Age started oral contraceptive pill	0.6	0.7	1.7	0.5	-0.8	0.8	0.9	-0.7	-0.8	0.7	-0.3	1.3	1.3
Diastolic blood pressure, automated reading	2.3	7.1	18.3	-1.2	3.4	0.7	-1.6	4.0	3.1	2.9	4.3	-0.2	-1.6
Ever depressed for a whole week	0.3	0.4	1.7	-0.7	0.1	-0.5	-0.8	-0.2	-0.4	0.0	-1.3	-0.8	-0.2
Unable to work because of sickness or disability	1.6	2.1	3.5	1.4	1.9	0.7	-1.9	1.8	1.9	1.6	0.2	-0.9	-1.1
Commuting to job workplace: Cycle	2.9	3.5	8.9	0.2	-1.9	-2.3	-0.8	-2.5	-1.7	-3.0	-2.0	-1.7	-0.7
Myopia	0.9	1.2	3.2	-0.3	-0.7	1.0	1.3	-0.8	-1.2	0.5	-1.8	1.1	1.6
Vascular/heart problems diagnosed by doctor	0.8	2.2	6.7	-2.6	-1.1	-0.3	2.0	-0.9	-1.5	0.4	-1.5	1.1	1.7
Cholesterol lowering medication	0.5	0.7	2.2	0.2	-0.9	-0.6	-0.5	-0.8	0.7	-1.5	-1.1	-0.8	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	2.0	1.4	-0.4	0.1	0.9	-0.5	-0.4	0.8	-0.3	-0.3	0.5
Pain experienced in last month	1.3	2.1	5.6	-2.1	-1.9	0.4	1.7	-1.2	-2.4	-0.2	-0.0	1.0	1.3
Supplements: Calcium	0.2	0.2	0.8	0.3	0.0	0.9	-0.8	-0.3	0.5	0.2	-0.3	-0.1	0.0
Basal cell carcinoma (self-reported)	1.0	1.2	3.8	0.6	-1.1	-0.9	0.4	-1.9	-1.2	-0.7	-1.8	0.1	0.8
Heart attack/myocardial infarction (self-reported)	1.1	1.4	3.0	1.2	-1.7	1.0	1.1	-1.3	-0.4	0.7	-1.7	0.8	1.4
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.2	-0.2	-1.1	0.6	0.6	-0.9	0.3	-0.5	0.9	-0.2	-0.2
Heart disease (siblings)	0.7	0.9	5.3	2.3	-0.6	0.8	0.7	0.8	0.4	0.8	0.4	0.5	0.5
Alcohol drinker status: Previous	0.7	0.8	3.3	1.0	0.5	1.0	-0.1	0.7	1.4	1.8	0.5	0.2	0.1
Pack years of smoking	0.5	0.7	3.5	1.9	0.7	0.1	-0.8	0.1	0.7	0.6	-0.2	-0.8	-0.8
Impedance of whole body	0.3	1.8	4.1	0.5	-0.5	1.4	1.5	-0.9	-1.8	0.6	-1.5	1.5	2.0
Leg fat mass (left)	0.3	1.2	5.1	2.2	0.2	-1.4	0.7	-0.9	0.6	-1.5	0.1	0.6	0.3
Arm predicted mass (left)	0.2	1.2	3.0	1.0	0.6	-1.6	-1.1	0.2	1.7	-0.9	0.7	-0.8	-1.2