Hub : Genes

ACER3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Visceral Omentum 0.1270 0.0550 7.5e-03 -0.002 NA -0.005 NA 0.002 4.6e-01 NA 8.2e-01 NA 2.4e-01
2 GTEx Esophagus Mucosa 0.0940 0.0350 4.4e-04 0.044 NA 0.011 NA 0.031 6.0e-04 NA 5.4e-02 NA 3.4e-03
3 GTEx Testis 0.3290 0.0950 3.2e-03 0.233 NA 0.208 NA 0.219 1.1e-10 NA 1.3e-09 NA 4.6e-10
4 METSIM Adipose 0.2319 0.0368 0.0e+00 0.209 0.219 0.275 0.260 0.279 1.2e-30 3.6e-32 3.7e-41 1.2e-38 5.8e-42
5 ROSMAP Brain Pre-frontal Cortex 0.3019 0.0512 0.0e+00 0.278 0.233 0.290 0.266 0.280 6.5e-36 1.7e-29 1.2e-37 3.8e-34 3.8e-36
6 YFS Blood 0.0626 0.0164 3.9e-13 0.028 0.043 0.035 0.043 0.041 1.1e-09 5.1e-14 1.1e-11 5.6e-14 2.3e-13
7 TCGA Kidney Renal Clear Cell Carcinoma 0.1406 0.0516 5.6e-07 0.074 0.079 0.083 NA 0.081 1.0e-08 3.3e-09 1.3e-09 NA 1.9e-09
8 TCGA Ovarian Serous Cystadenocarcinoma 0.0770 0.0580 4.3e-04 0.047 0.050 0.057 NA 0.036 3.9e-04 2.5e-04 1.0e-04 NA 1.7e-03
9 TCGA Pancreatic Adenocarcinoma 0.3190 0.1390 7.9e-04 0.091 0.075 0.049 NA 0.066 1.2e-04 4.5e-04 4.0e-03 NA 1.0e-03
10 TCGA Prostate Adenocarcinoma 0.2243 0.0623 0.0e+00 0.200 0.200 0.202 NA 0.202 1.5e-20 1.6e-20 8.8e-21 NA 1.0e-20

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 0.8 1.2 3.6 -0.8 1.1 1.1 0.3 1.3 1.4 1.9 0.9 0.9 0.4
Bipolar Disorder or Schizophrenia 0.6 1.5 3.3 0.3 1.7 1.3 0.0 1.8 0.8 1.8 1.5 0.7 0.2
Depressed Affect (Nagel 2018) 0.3 0.7 1.3 1.1 -0.4 0.6 0.9 -0.8 -0.4 1.1 0.5 1.2 1.0
Depression (Nagel 2018) 0.8 1.2 2.9 0.7 -0.3 0.1 1.2 -0.3 -1.4 1.6 -0.4 1.7 1.6
Intelligence (Savage-Jansen 2018) 2.0 6.3 15.7 0.4 -4.0 -0.0 3.6 -2.6 -3.5 -1.2 -1.7 1.8 2.8
Neuroticism (Nagel 2018) 0.7 1.8 3.4 0.6 -0.5 1.2 1.6 -0.9 -1.6 1.6 -0.6 1.7 1.8
Schizophrenia (2018) 0.3 0.7 1.8 1.0 1.3 0.8 -0.2 1.3 -0.1 0.7 1.1 0.2 -0.2
Schizophrenia vs Biploar Disorder 0.2 0.3 1.2 1.1 -0.0 0.3 -0.3 0.1 -0.8 -0.0 -0.9 -0.4 0.1
Worry (Nagel 2018) 0.6 1.2 5.4 -0.2 -0.6 -0.2 0.5 -1.5 -2.3 0.1 -1.8 0.2 0.7
Alzheimer’s Disease (in mother) 0.5 0.6 1.7 0.7 1.1 0.1 -0.1 0.5 0.7 0.3 1.3 1.1 0.4
Alzheimer’s Disease (in father) 0.2 0.2 0.7 0.2 0.2 0.3 0.8 -0.3 -0.6 0.2 -0.5 0.7 0.6
Alzheimer’s Disease (including proxy) 0.6 0.9 2.2 0.8 1.4 0.7 -0.1 0.7 0.9 0.9 1.5 1.1 0.3
Crohns Disease (2017) 0.5 1.1 2.7 1.5 1.1 0.9 -0.5 1.5 -0.1 0.1 1.6 -0.8 -1.0
Irritable Bowel Disease (IBD) 0.8 2.0 6.0 -0.1 2.0 1.3 -1.1 2.5 0.7 1.0 1.9 -0.6 -1.1
Ulcerative Colitis (UC) 1.5 2.7 7.6 -1.3 2.1 1.5 -1.2 2.7 1.5 1.8 2.0 -0.0 -0.9
Major Depression (MDD) 2.0 2.4 5.9 1.5 0.9 1.9 0.8 1.2 2.3 2.4 1.1 1.4 1.0
Reaction Time 0.4 0.7 4.2 2.0 0.5 -0.4 -0.8 0.8 -0.8 0.5 -0.5 -0.1 -0.3
Verbal and Numeric Reasoning (VNR) 3.3 7.9 16.2 0.2 -4.0 1.1 3.8 -3.0 -3.4 -0.4 -2.6 2.5 3.6
Breast Cancer 0.2 0.4 1.1 1.0 0.1 0.6 1.1 -0.5 0.8 0.3 0.2 0.3 0.6
Ovarian Cancer 0.2 0.2 0.8 -0.1 0.6 -0.9 -0.0 0.1 0.3 -0.9 0.3 -0.0 -0.4
Prostate Cancer 0.1 0.2 0.7 -0.1 -0.5 -0.1 -0.5 -0.6 -0.5 -0.3 -0.8 -0.4 -0.2
Age at First Birth 0.2 0.3 2.3 -1.5 0.4 -0.1 0.6 0.2 -0.2 0.0 -0.1 0.4 0.3
Bipolar Disorder (2011) 2.8 2.7 7.6 -1.2 1.5 2.8 0.0 1.7 1.1 2.6 1.8 1.4 0.6
Body Mass Index (BMI) (2010) 0.2 0.3 0.6 0.8 0.6 -0.2 0.4 0.3 0.8 0.2 0.4 0.6 0.3
Coronary Artery Disease (CAD) 1.0 1.3 2.5 1.4 -1.2 -1.6 0.7 -1.4 -1.1 -1.6 -0.8 0.2 0.2
Crohns Disease (2012) 0.4 0.7 3.0 1.1 0.4 1.1 0.6 0.7 0.8 0.2 1.7 -0.0 -0.1
Mean Putamen Volume 0.3 0.3 1.0 -1.0 0.4 -0.4 -0.7 0.5 -0.5 0.5 -0.2 -0.3 -0.4
Fasting Glucose 0.3 0.4 1.2 -0.1 -0.1 1.1 0.3 0.4 0.3 -0.4 0.7 1.1 0.6
HbA1C 0.9 1.0 2.2 -1.5 1.2 -1.2 -0.4 0.5 0.5 -0.4 1.0 -0.9 -1.5
HDL Cholesterol 0.9 1.6 4.3 -1.8 -1.4 -0.4 0.8 -1.7 -2.1 -0.7 -1.0 0.3 0.8
LDL Cholesterol 0.5 0.8 1.5 1.1 0.3 1.2 1.0 0.5 0.4 0.9 1.2 1.2 0.6
Lupus 0.1 0.2 0.5 -0.4 -0.1 -0.1 -0.1 -0.4 -0.5 -0.4 -0.7 -0.6 -0.2
Neuroticism (2016) 0.6 0.9 4.2 0.4 0.7 0.9 -0.9 1.2 0.7 2.1 0.8 0.4 -0.0
Primary Biliary Cirrhosis 0.5 0.7 1.6 -0.6 0.3 0.9 0.4 1.1 -0.1 1.2 -0.2 1.3 1.1
Rheumatoid Arthritis 2.0 2.7 7.3 -0.2 -2.0 -0.4 1.7 -2.5 -1.4 -0.7 -2.7 1.0 1.8
Schizophrenia (2014) 0.9 2.1 5.5 1.2 1.7 2.1 0.0 2.0 0.5 2.4 1.2 0.8 0.5
Triglycerides 0.2 0.4 1.4 0.9 -0.2 -0.7 0.3 -0.5 -0.5 -1.2 -0.4 0.2 0.2
Type 2 Diabetes (T2D) (2012) 0.2 0.2 1.3 -1.1 0.1 -0.1 0.1 0.1 0.4 0.4 0.5 0.5 0.3
Ulcerative Colitis 1.1 1.5 4.0 -2.0 1.0 1.9 -0.4 1.5 0.5 1.4 1.1 0.8 0.2
Blood Eosinophil Count 0.5 3.9 28.2 5.3 -1.5 -1.0 -0.3 -1.2 -1.7 -0.5 -1.4 -0.8 -0.2
Blood Platelet Count 0.4 4.8 44.1 6.6 -0.4 -0.0 0.9 -0.2 0.1 -0.1 1.7 0.2 -0.1
Blood Red Count 0.3 2.7 5.6 -1.9 1.3 -1.6 -1.9 0.4 1.3 -1.7 1.6 -1.7 -2.4
Blood White Count 0.8 6.2 16.0 2.8 -0.1 -4.0 -2.0 -1.7 -0.3 -3.8 -1.2 -2.9 -2.5
Heel T-Score 0.9 7.1 16.9 -1.8 2.7 -2.5 -3.8 2.3 1.1 -0.6 2.1 -3.4 -4.1
BMI 0.2 1.1 3.3 1.1 -0.5 -1.6 1.0 -1.0 1.0 -1.8 0.3 0.5 0.1
Height 0.1 1.4 7.8 -2.8 -0.1 -1.6 -0.4 -0.8 -0.8 -1.1 -0.9 -0.5 -0.3
Waist Hip Ratio (WHR) 0.1 0.5 2.3 0.0 0.6 1.5 0.4 -0.1 -0.5 0.9 -0.2 0.4 0.6
Systolic Blood Pressure 1.7 8.4 19.8 2.3 3.0 2.6 -0.2 4.3 3.0 4.5 3.6 1.7 0.5
Smoking Status 0.1 0.3 0.9 0.1 -0.3 -0.4 -0.8 -0.4 0.9 -0.1 -0.6 -0.9 -0.6
Allergy or Eczema 0.8 2.1 7.4 2.7 -0.6 2.6 0.7 -0.1 -1.0 1.4 0.6 1.1 1.2
Cardiovascular Disease 0.6 2.1 5.3 2.3 1.2 -0.6 -2.1 1.3 1.6 -0.6 1.4 -0.8 -1.7
Hypothyroidism (self reported) 0.9 2.0 11.4 3.4 -1.7 -0.3 1.1 -1.2 0.1 -0.8 -0.8 0.7 0.9
Respiratory disease 0.8 1.8 9.7 3.1 1.6 0.8 -0.6 1.3 0.3 0.5 1.5 -0.1 -0.7
Type 2 Diabetes (T2D) (2018) 0.3 0.6 1.5 0.9 0.2 -0.9 -1.0 -0.2 0.5 -0.4 -0.4 -1.2 -1.1
Lung FEV1/FVC ratio 0.9 4.5 12.0 1.1 3.5 -0.6 -2.0 2.9 2.8 0.3 2.0 -1.4 -2.2
Lung FVC 0.2 0.9 3.3 -1.8 -0.8 -0.4 -1.5 -0.0 0.6 -0.3 0.1 -1.1 -1.1
Neuroticism 0.5 1.2 3.0 -0.5 0.5 1.3 0.7 -0.1 -1.3 1.6 0.0 1.7 1.4
Chronotype (morning person) 0.4 0.8 2.1 1.4 0.2 -0.8 -1.1 0.4 0.6 -0.7 -0.2 -1.4 -1.2
Hair Pigment 0.0 1.0 3.4 -1.0 0.3 -1.9 -0.8 -0.2 -1.0 -1.6 -0.1 -0.9 -1.0
Tanning 0.0 0.6 1.7 0.2 -0.7 1.1 1.1 -0.5 -0.2 0.4 -1.3 0.0 0.9
Hand grip strength (left) 0.4 1.2 3.0 1.7 0.4 -1.7 -1.0 0.1 1.6 -1.0 0.4 -0.3 -0.9
Number of treatments/medications taken 1.1 2.0 5.3 2.3 1.7 0.8 -1.7 1.4 2.1 0.1 0.8 -0.3 -0.9
Average weekly spirits intake 0.3 0.4 1.4 0.5 1.2 -0.4 -0.5 0.7 1.1 -0.1 0.6 0.1 -0.4
Sensitivity / hurt feelings 0.1 0.2 0.6 -0.6 0.5 -0.3 -0.2 -0.2 -0.3 0.1 -0.7 0.3 0.2
Frequency of depressed mood in last 2 weeks 0.3 0.5 2.8 0.1 0.7 0.3 0.2 0.2 -0.3 1.7 0.4 0.8 0.4
Hearing difficulty/problems: Yes 0.1 0.1 0.4 0.5 -0.3 -0.7 -0.5 0.2 -0.3 -0.1 -0.1 -0.0 -0.1
Relative age of first facial hair 1.0 2.0 5.5 -0.5 1.1 -1.7 -2.3 1.1 0.3 -1.0 1.6 -1.2 -2.0
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 2.5 -0.7 -0.8 -0.6 -0.6 -1.1 -0.1 -1.6 -0.7 -1.2 -0.7
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.6 0.1 0.5 -0.0 -0.7 -0.6 0.6 -0.4 -0.4 -0.2 -0.4
Ever had hysterectomy (womb removed) 0.4 0.4 1.2 0.1 0.5 0.6 -0.1 0.7 1.1 1.0 0.4 0.5 0.2
Systolic blood pressure, automated reading 2.4 7.0 15.9 2.3 2.8 1.8 -0.6 4.0 2.6 3.7 3.9 1.1 -0.2
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 1.2 -0.4 -0.7 -0.8 -0.0 -1.1 -1.0 -0.8 -1.1 -0.2 0.1
Angina 0.3 0.4 1.8 -0.6 0.4 -0.2 -1.3 -0.0 0.3 0.4 -0.9 -0.4 -0.4
Medication for hormone replacement therapy 0.3 0.3 1.0 -1.0 0.8 0.6 0.0 0.3 0.2 0.5 0.9 0.1 -0.1
Vitamin and mineral supplements 0.5 0.7 1.5 0.3 -0.9 -0.2 1.1 -1.2 -0.8 -0.0 0.0 1.1 1.1
Supplements: Zinc 1.0 1.1 2.8 0.5 0.9 -0.9 -0.7 0.8 1.7 -0.7 1.4 -1.1 -1.4
Medication: Co-codamol 0.5 0.6 1.8 0.7 -0.8 0.4 0.2 -0.0 0.3 0.6 -1.0 1.4 1.2
Medication: Metformin 1.2 1.8 4.7 0.7 -0.0 -2.2 -1.0 -0.7 -0.5 -2.2 -1.1 -1.7 -1.4
Diabetes (father) 0.9 1.1 3.5 -0.6 -0.9 -1.3 -0.4 -0.6 -0.3 -1.9 -0.4 -1.5 -1.2
Diabetes (mother) 0.3 0.4 1.4 -1.2 -0.7 0.1 0.7 -0.9 0.6 0.1 -0.2 0.1 0.4
Severe depression (siblings) 0.6 0.7 4.5 0.8 0.3 -0.0 -0.4 0.6 0.5 -0.2 2.1 -0.0 -0.8
Pack years adult smoking proportion 0.4 0.6 3.0 1.7 0.4 0.1 -0.7 0.2 0.8 0.7 -0.3 -0.8 -0.7
Impedance of leg (right) 0.2 1.0 2.4 0.8 0.3 1.1 1.2 -0.3 -1.2 0.8 -0.6 1.4 1.6
Leg fat-free mass (left) 0.1 0.6 2.0 0.3 -0.1 -1.4 -0.7 -0.4 1.0 -1.1 0.3 -0.6 -0.8
Trunk fat percentage 0.3 1.1 5.2 2.3 0.1 -0.5 1.2 -1.2 0.4 -0.9 -0.3 0.9 0.9
Hand grip strength (right) 0.6 1.6 4.4 1.1 1.0 -1.4 -1.3 0.7 2.1 -1.1 1.5 -0.6 -1.5
Townsend deprivation index at recruitment 0.1 0.1 0.4 -0.3 -0.4 0.2 0.2 0.0 -0.6 -0.2 0.4 0.1 0.0
Current tobacco smoking 0.9 1.5 4.5 -0.1 0.8 -1.1 -1.8 1.0 2.1 -0.2 0.1 -1.4 -1.6
Average weekly fortified wine intake 0.8 0.9 3.1 0.6 -1.8 -0.5 1.1 -1.2 -0.8 -0.7 -0.8 0.3 0.8
Maternal smoking around birth 0.4 0.6 1.5 0.5 0.8 -0.4 -1.1 0.1 0.4 -0.4 -1.2 -1.1 -0.8
Fed-up feelings 0.1 0.2 0.7 0.5 0.8 0.4 -0.1 -0.2 0.3 0.5 -0.2 0.2 0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 2.1 1.4 0.2 0.0 -0.0 -0.0 -0.5 0.3 -0.7 0.4 0.3
Relative age voice broke 0.5 0.8 3.0 -0.8 1.0 -0.8 -1.0 0.9 0.4 0.1 1.7 0.1 -0.7
Taking other prescription medications 0.6 0.9 7.3 2.7 0.4 0.2 -0.8 -0.2 -0.0 -0.7 -0.2 0.0 -0.2
Age when periods started (menarche) 0.7 1.8 6.7 0.7 0.7 2.6 0.7 0.9 -0.1 1.7 0.5 1.9 1.5
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.7 1.1 -1.3 -0.4 0.5 -1.1 -0.1 -0.2 -1.1 -0.5 0.3
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.2 6.8 -0.9 -0.1 -1.1 -1.9 0.3 0.5 -0.8 1.4 -2.6 -2.5
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 1.5 1.2 -0.6 -0.3 -0.2 -1.0 1.0 -1.1 -0.3 0.2 0.1
Qualifications: CSEs or equivalent 1.6 2.1 4.8 -0.3 -2.0 -1.8 -0.1 -1.6 -0.4 -2.2 -1.6 -1.6 -0.7
Serious illness, injury or assault to yourself 2.4 2.9 9.1 -0.7 1.5 -1.7 -3.0 0.7 0.8 -0.4 0.7 -2.4 -2.6
High blood pressure 1.2 3.5 7.7 2.8 1.7 0.3 -2.6 1.5 1.7 -0.5 2.1 -1.5 -2.3
Hayfever, allergic rhinitis or eczema 0.9 2.1 7.6 2.8 -1.6 2.1 1.0 -1.0 -1.4 0.3 0.4 0.8 1.0
Multivitamins +/- minerals 0.5 0.6 1.7 -0.8 1.3 0.7 -0.5 1.3 0.1 1.0 0.6 0.1 -0.3
Stomach or abdominal pain in last month 1.1 1.3 3.6 -0.1 1.4 0.6 -1.5 1.1 1.6 1.9 0.2 -0.8 -0.8
Supplements: Glucosamine 0.7 0.9 2.8 -0.3 1.6 0.9 -0.9 1.7 0.5 0.7 0.9 -0.5 -0.8
Diverticular disease/diverticulitis (self-reported) 1.4 1.7 4.0 0.9 1.4 1.2 -0.1 1.4 2.0 1.9 1.1 1.3 0.5
Medication: Atenolol 3.7 4.7 11.4 1.4 2.6 2.0 -0.9 2.4 2.7 3.4 2.6 1.2 -0.1
Medication: Levothyroxine sodium 0.4 0.7 1.9 1.0 -1.4 -1.0 1.0 -0.8 -0.5 -0.7 -0.2 0.2 0.3
Sitting height 0.0 0.3 1.5 -1.2 -0.6 -0.3 -0.4 -0.3 0.6 0.1 -0.0 0.2 0.2
Chronic bronchitis/emphysema (father) 0.4 0.5 3.4 1.9 -0.2 -0.1 -0.7 -0.4 -0.1 -0.1 -0.7 0.4 0.1
High blood pressure (mother) 0.5 0.7 1.9 0.9 0.8 0.2 -0.8 0.7 0.5 0.1 1.4 -0.8 -1.2
Body mass index (BMI) 0.2 0.9 3.1 1.8 0.4 -1.4 0.2 -0.5 1.0 -1.2 0.6 -0.1 -0.5
Impedance of leg (left) 0.1 0.7 1.9 1.4 0.3 0.5 1.0 -0.4 -0.9 0.4 -0.8 0.9 1.1
Leg predicted mass (left) 0.1 0.6 2.0 0.2 -0.1 -1.4 -0.6 -0.4 1.0 -1.0 0.3 -0.6 -0.8
Trunk fat mass 0.2 0.8 3.1 1.8 0.0 -0.9 0.8 -1.1 0.6 -1.1 -0.2 0.7 0.5
Waist circumference 0.1 0.5 2.5 1.6 0.4 -0.2 0.6 -0.5 0.5 -0.2 0.3 0.9 0.5
Number of incorrect matches in round 1.0 1.7 4.7 -0.7 1.5 0.9 0.9 1.7 0.2 1.6 1.2 2.2 1.1
Past tobacco smoking 0.4 0.8 2.8 0.1 1.2 -0.5 -0.5 1.7 0.9 0.4 1.3 -0.1 -0.7
Alcohol usually taken with meals 0.5 0.8 1.8 -1.2 -1.1 0.2 1.3 -0.5 -0.5 -0.2 -1.1 0.7 1.1
Nervous feelings 0.5 1.0 3.1 1.1 0.5 0.4 0.4 -0.6 -1.1 1.3 -1.8 0.9 1.1
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.7 0.0 0.6 1.2 0.3 0.8 -0.4 1.3 0.4 1.0 0.7
Hearing difficulty/problems with background noise 0.3 0.5 1.8 0.2 -0.4 -0.9 -0.9 -0.2 0.2 -1.4 -0.5 -0.7 -0.7
Hair/balding pattern: Pattern 2 1.8 2.3 5.4 1.6 1.5 0.8 0.3 1.0 2.3 2.3 1.7 1.5 0.6
Had menopause 2.0 2.5 5.9 -1.3 -1.1 1.7 1.6 -0.8 -1.7 0.7 -0.9 2.4 2.4
Had other major operations 0.5 0.6 5.7 -2.4 -0.2 0.1 -0.0 0.4 -0.3 0.2 -0.2 0.3 0.4
Forced vital capacity (FVC) 0.2 0.7 4.1 -2.0 -0.7 -0.8 -0.6 0.4 0.8 -0.5 0.5 -0.5 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.8 4.2 -0.7 1.1 -0.9 -2.0 1.5 0.6 0.5 1.5 -1.5 -2.0
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.6 -0.2 -0.4 -0.7 -1.0 -0.8 -0.3 -0.7 -1.2 -1.2 -0.6
Qualifications: None of the above 0.8 1.7 6.6 2.6 1.5 1.1 -0.8 1.1 1.6 1.4 0.6 0.1 -0.3
Financial difficulties in last 2 years 0.3 0.4 1.4 -0.8 0.4 -0.5 -1.2 0.6 -0.3 0.3 -0.2 -0.9 -0.8
Mouth/teeth dental problems 0.5 0.8 3.4 -1.9 -0.8 0.4 -0.1 0.4 1.7 0.6 0.5 0.1 -0.0
Heart attack 0.8 1.1 2.4 1.6 -1.1 1.2 0.7 -0.9 0.0 0.9 -1.3 0.7 1.1
Allergy 1.0 2.3 14.7 -3.8 0.9 -1.9 -0.8 0.3 0.7 -0.6 -1.1 -0.5 -0.5
Pain all over the body in last month 0.3 0.3 1.2 1.1 -0.4 0.3 0.1 -0.4 0.5 0.7 -0.8 -0.4 0.0
Diabetes (self-reported) 0.4 0.6 4.9 2.2 0.4 -0.1 -0.4 -0.1 -0.1 -0.1 -1.0 0.3 0.2
Hayfever/allergic rhinitis (self-reported) 1.4 1.9 6.1 2.5 0.1 1.9 0.3 1.1 0.6 1.6 1.7 1.3 0.7
Medication: Ramipril 0.3 0.3 1.2 -0.8 0.8 1.1 -0.1 0.4 0.3 0.5 0.1 0.5 0.1
Medication: Simvastatin 0.6 0.9 3.2 0.0 -0.8 -1.0 -0.5 -1.1 -0.2 -1.5 -1.8 -0.3 -0.1
Fluid intelligence score 3.2 6.7 13.6 -0.6 -3.7 1.3 3.5 -3.0 -2.6 -0.2 -2.3 2.3 3.5
Illnesses of siblings 0.8 1.1 2.8 -1.1 -1.3 -0.6 0.1 -1.7 -1.5 -1.3 -0.9 -0.6 0.0
Neuroticism score 0.2 0.3 0.9 -0.3 0.5 0.7 -0.3 -0.3 -1.0 0.9 0.1 0.5 0.3
Weight 0.1 0.6 2.0 1.1 -0.0 -1.4 0.2 -0.8 0.9 -1.1 0.1 0.3 -0.0
Impedance of arm (right) 0.5 2.5 5.1 0.3 -1.4 1.4 1.9 -1.4 -2.3 0.2 -1.9 1.5 2.2
Arm fat percentage (right) 0.2 0.9 4.1 2.0 0.1 -0.7 1.0 -0.8 0.5 -1.2 0.1 0.9 0.6
Trunk fat-free mass 0.1 0.8 2.4 -0.1 0.1 -1.6 -1.0 0.3 1.4 -0.6 0.4 -0.7 -1.0
Hip circumference 0.3 1.2 5.0 2.2 -0.3 -1.0 1.1 -0.9 1.0 -0.9 0.2 1.3 0.9
Time employed in main current job 1.0 1.1 2.8 -0.0 1.4 0.9 -0.9 0.8 1.4 0.1 1.7 -0.9 -1.2
Alcohol intake versus 10 years previously 0.8 1.2 4.3 0.1 0.0 -1.7 -1.3 0.1 0.0 -0.4 0.1 -2.1 -1.7
Father’s age at death 0.2 0.3 2.1 -1.4 0.4 -0.5 -0.4 -0.3 -0.4 -0.2 -0.5 0.2 0.2
Worrier / anxious feelings 0.2 0.4 1.1 -0.7 -0.4 -0.2 -0.0 -1.0 -0.9 0.7 -0.6 0.6 0.5
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 2.9 1.7 -0.1 1.1 0.5 -0.3 0.4 0.2 -0.5 0.3 0.7
Falls in the last year 0.2 0.3 1.2 -1.1 -0.5 -0.3 -0.1 -0.4 -0.7 -0.3 -0.4 0.0 0.3
Hair/balding pattern: Pattern 3 2.0 2.9 7.0 -1.8 -1.9 0.2 1.5 -2.0 -2.3 -1.1 -2.6 0.8 1.5
Number of live births 0.3 0.4 1.2 1.1 -1.1 -0.5 -0.1 -0.6 0.3 -0.6 0.2 -0.4 -0.3
Forced expiratory volume in 1-second (FEV1) 0.2 0.8 2.0 -1.2 0.2 -0.5 -0.7 1.2 1.1 0.1 1.4 -0.3 -0.7
Pulse rate 1.6 2.7 5.2 2.1 1.1 -2.3 -1.6 0.8 1.1 -1.2 1.2 -1.9 -2.3
Happiness 1.1 1.3 7.0 0.2 -0.1 -0.4 0.6 -0.8 -1.3 0.6 -2.6 0.9 1.5
Noisy workplace 1.8 2.2 3.9 1.7 1.0 -2.0 -1.3 0.5 1.0 -2.0 1.5 -1.2 -1.9
Qualifications: A levels/AS levels or equivalent 0.7 1.5 3.6 -0.6 -1.9 -0.7 1.0 -1.8 -1.8 -1.7 -0.7 -0.1 0.5
Serious illness, injury or assault of a close relative in last 2 years 1.7 2.0 10.6 0.1 2.1 0.4 0.9 1.4 0.8 0.7 3.3 0.9 -0.1
Mouth/teeth dental problems: Dentures 0.2 0.3 1.3 1.2 0.2 -0.6 -0.1 -0.8 -0.3 -0.8 -0.2 -0.5 -0.3
Asthma 1.3 2.6 13.1 3.6 1.8 0.7 -1.0 1.8 0.8 1.1 1.6 0.1 -0.7
Medication: Ibuprofen (e.g. Nurofen) 1.9 2.4 8.6 1.4 1.6 0.7 -1.8 1.7 2.9 1.2 1.4 -0.5 -1.1
Medication: Cholesterol lowering 0.1 0.2 0.9 0.6 -0.4 -0.1 -0.6 -0.5 -0.3 -0.3 -1.0 -0.0 -0.0
Depression (self-reported) 1.0 1.2 4.0 0.3 -1.3 -0.6 0.3 -1.6 -1.2 -1.1 -2.0 -0.3 0.3
Medication: Lansoprazole 0.3 0.4 1.0 0.9 -0.4 -0.1 0.6 -1.0 -0.9 0.2 -0.8 -0.1 0.4
Prospective memory result 0.3 0.3 1.0 0.3 0.8 0.5 -0.2 0.7 1.0 0.8 -0.1 0.4 0.2
Lung cancer (father) 0.9 1.1 3.5 1.4 0.9 1.6 0.1 0.8 0.0 1.9 -0.2 0.8 0.6
Illnesses of mother 0.7 0.9 4.2 -0.8 -0.4 -0.9 -0.7 -0.6 -1.4 -0.6 -2.0 -0.5 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 1.4 -0.8 -0.1 -0.1 -0.3 0.7 1.2 0.7 1.1 -0.0 -0.3
Pulse wave Arterial Stiffness index 0.1 0.1 0.5 -0.4 0.1 0.0 0.2 0.3 -0.2 0.2 -0.7 0.0 0.0
Impedance of arm (left) 0.6 2.6 5.5 -0.3 -1.5 1.2 1.8 -1.4 -2.4 0.2 -2.1 1.4 2.2
Arm fat mass (right) 0.2 0.9 3.6 1.9 0.1 -1.3 0.5 -0.9 0.8 -1.4 0.2 0.3 0.1
Trunk predicted mass 0.1 0.8 2.7 -0.1 0.1 -1.6 -1.0 0.3 1.4 -0.6 0.4 -0.8 -1.1
Standing height 0.1 0.6 1.6 -1.1 -1.0 -0.5 -0.0 -1.0 -0.2 -0.4 -1.3 0.5 0.8
Length of working week for main job 0.6 0.7 2.5 -1.6 0.2 -1.2 0.6 0.2 0.5 -0.7 1.2 0.7 -0.0
Exposure to tobacco smoke at home 0.4 0.4 1.6 -0.0 -0.6 -0.7 0.4 -0.6 -0.9 0.1 -1.3 0.1 0.6
Breastfed as a baby 0.7 0.8 2.2 -0.6 1.5 0.1 -0.7 1.5 1.1 0.6 1.1 0.1 -0.4
Tense / ‘highly strung’ 1.4 2.3 5.3 0.7 -0.9 0.8 2.0 -1.2 -1.5 0.6 -2.3 1.6 2.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.8 -0.1 0.3 0.3 0.4 0.3 0.9 0.8 -0.0 0.8 0.7
Hair/balding pattern: Pattern 4 0.6 1.5 3.3 -1.8 0.9 -0.6 -1.0 1.1 0.8 -0.8 1.8 -1.2 -1.5
Birth weight of first child 1.4 2.5 7.4 -1.7 1.1 -1.4 -2.7 0.6 0.4 -0.7 0.2 -2.3 -2.3
Peak expiratory flow (PEF) 0.5 1.1 3.5 0.2 1.0 0.6 -1.1 1.6 1.9 0.9 1.1 -0.1 -0.6
Pulse wave reflection index 0.7 0.8 3.5 -1.9 0.4 1.1 0.3 0.9 -0.1 1.4 0.1 0.5 0.5
Ever highly irritable/argumentative for 2 days 0.5 0.5 2.9 0.1 0.4 -0.1 -0.2 -0.5 -0.4 0.3 -1.7 1.1 0.8
Loud music exposure frequency 1.3 1.4 3.3 -0.4 -0.7 -1.1 0.8 -1.4 -1.7 -0.9 -1.8 1.1 1.1
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.8 -0.6 -0.1 -0.0 0.3 0.3 0.5 0.3 0.9 0.1 0.1
Mouth/teeth dental problems: Bleeding gums 0.8 1.1 2.2 1.5 1.0 1.1 1.0 0.5 -1.2 0.9 0.4 1.2 1.1
Blood clot in the leg (DVT) 0.3 0.4 1.1 -0.1 -0.9 0.3 0.3 -0.6 0.3 -0.6 1.1 -0.4 -0.5
Medication: Paracetamol 1.4 2.3 4.0 2.0 1.9 1.2 -1.3 1.9 1.9 1.4 1.7 0.3 -0.6
Headache pain in last month 0.4 0.6 2.2 1.5 -0.5 -0.0 -0.6 -0.2 1.2 -1.0 0.2 -0.7 -0.5
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.9 -0.3 -0.2 0.1 0.7 0.4 0.1 1.0 0.0 -0.2 0.2
Glaucoma (self-reported) 1.6 1.9 4.8 -0.0 -0.2 -2.2 -1.2 -0.6 -1.3 -2.1 -1.3 -1.7 -1.4
Gout (self-reported) 0.2 0.2 0.7 0.3 0.2 -0.8 -0.8 -0.0 0.2 -0.5 0.0 -0.4 -0.6
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 4.3 2.1 -1.3 -0.5 0.7 -0.5 -0.3 -0.7 -0.4 0.3 0.5
Medication: Amlodipine 1.3 1.9 3.6 1.7 1.5 -0.3 -1.6 1.0 1.3 -0.9 1.2 -1.6 -1.9
Medication: Ventolin 100micrograms inhaler 1.7 2.2 5.0 -0.1 2.1 1.9 -0.3 2.2 1.0 1.7 1.9 0.9 0.1
Birth weight 0.4 0.9 2.1 -1.5 0.9 -0.2 -1.3 1.0 1.1 -0.1 0.4 -1.0 -1.2
Chronic bronchitis/emphysema (mother) 0.5 0.6 2.1 -0.4 -0.9 -0.2 0.7 -1.5 -0.8 -0.7 -0.8 0.5 0.6
High blood pressure (siblings) 0.7 1.0 3.3 -0.7 1.8 -1.1 -1.0 1.3 0.7 0.1 0.8 -0.4 -0.9
Forced vital capacity (FVC), Best measure 0.1 0.3 1.8 -1.3 -0.7 -0.2 -0.3 0.1 0.6 0.5 0.2 0.0 0.1
Body fat percentage 0.3 1.2 5.3 2.3 -0.0 -0.7 1.4 -1.2 0.3 -1.1 -0.2 1.1 0.9
Leg fat percentage (right) 0.3 1.1 5.1 2.2 0.6 -0.9 1.1 -0.7 0.5 -1.1 0.5 1.2 0.6
Arm fat-free mass (right) 0.2 1.3 3.3 0.5 0.5 -1.6 -1.3 0.3 1.8 -0.7 0.8 -1.1 -1.4
Exposure to tobacco smoke outside home 0.6 0.9 2.5 -0.2 0.5 -1.1 -1.5 -0.0 0.4 -0.7 0.2 -1.2 -1.6
Comparative body size at age 10 0.3 0.9 4.7 -0.4 -0.2 -2.2 -0.5 -0.7 -0.0 -1.4 0.5 -0.6 -1.0
Number of full brothers 0.4 0.5 2.4 0.8 -0.7 1.5 0.8 0.6 -0.2 0.7 0.3 0.1 0.5
Worry too long after embarrassment 0.5 0.9 3.7 0.0 -0.5 1.0 0.7 -0.4 -1.9 0.6 -0.0 1.2 1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 2.7 0.3 -0.6 -0.0 1.6 -1.1 -1.4 -0.4 -0.8 1.0 1.2
Wheeze or whistling in the chest in last year 0.3 0.5 1.7 1.3 0.7 0.4 -0.4 1.0 0.7 0.7 0.2 0.8 0.1
Number of children fathered 0.5 0.6 4.9 -2.2 -0.0 0.5 0.0 -0.4 0.0 0.0 -0.3 0.6 0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 2.1 -0.6 -0.5 1.4 1.2 -0.4 -0.3 -0.0 0.2 1.3 1.1
Age at first live birth 0.5 0.8 2.7 -1.3 0.7 -0.8 -0.6 -0.2 -1.6 0.4 -1.3 -0.5 -0.2
Pulse wave peak to peak time 0.1 0.1 0.4 0.2 -0.2 -0.1 -0.2 -0.4 0.1 -0.2 0.6 -0.0 -0.0
Health satisfaction 0.7 0.9 2.5 1.6 1.2 -0.7 -1.3 0.6 0.4 -0.5 -0.5 -1.0 -1.0
Shortness of breath walking on level ground 1.3 1.5 4.2 0.2 2.0 -1.8 -1.5 0.7 0.9 -0.8 0.6 -0.7 -1.6
Qualifications: College or University degree 0.3 1.1 2.9 -1.1 -0.5 1.2 1.0 -0.8 -1.7 0.6 -0.4 1.1 1.3
Eye problems/disorders: None of the above 0.7 0.8 2.0 -0.6 0.2 1.4 0.7 0.5 -0.5 1.1 1.4 0.9 0.6
Mouth/teeth dental problems: Loose teeth 0.3 0.4 1.1 0.4 0.5 -1.0 -0.1 -0.2 -0.2 -0.8 -1.0 0.6 0.3
Emphysema/chronic bronchitis 0.7 0.8 2.0 1.1 1.2 0.0 -0.3 1.2 1.0 0.6 1.4 0.0 -0.4
Medication for pain relief, constipation, heartburn 2.2 3.7 11.7 -3.4 -1.6 -0.1 1.8 -1.7 -3.0 -0.5 -1.8 1.2 1.8
Neck or shoulder pain in last month 1.3 1.9 5.1 2.3 1.6 1.4 -0.4 1.9 1.4 1.6 0.9 0.3 -0.1
Medication: Blood pressure 0.3 0.6 1.7 0.2 1.3 0.5 -1.0 0.8 1.1 -0.2 0.8 0.2 -0.5
Angina (self-reported) 0.2 0.3 1.2 -0.3 0.3 0.2 -1.1 -0.1 0.2 0.8 -0.9 -0.1 -0.1
Migraine (self-reported) 0.3 0.4 1.0 0.5 -0.1 -0.3 -1.0 -0.7 0.2 -0.9 -0.4 -0.8 -0.8
Medication: Ibuprofen 1.5 1.8 7.6 1.1 1.3 0.8 -1.5 1.2 2.8 1.2 1.1 -0.1 -0.6
Medication: Allopurinol 0.8 1.1 3.5 -0.7 1.9 -1.3 -1.4 0.7 1.0 0.1 0.3 -0.7 -1.2
Medication: Omeprazole 0.5 0.5 1.9 0.7 -0.5 0.3 1.4 -0.9 -0.5 0.4 -0.6 0.5 1.0
Medication: Seretide 50 evohaler 0.3 0.3 2.1 1.5 0.2 0.5 -0.6 0.3 0.6 0.2 0.1 -0.1 -0.2
Mean time to correctly identify matches 0.5 0.9 3.2 1.8 -0.4 -0.7 -0.2 -0.3 -1.6 -0.2 -1.7 0.2 0.4
Heart disease (mother) 0.4 0.4 1.3 0.9 -0.4 0.4 0.2 0.5 1.0 1.1 -0.8 -0.4 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.7 2.7 1.2 0.0 -0.3 0.4 -0.8 0.6 -1.6 -0.6 0.7 0.5
Whole body fat mass 0.2 0.9 3.8 2.0 -0.0 -1.1 0.8 -1.1 0.5 -1.2 -0.1 0.7 0.4
Leg fat mass (right) 0.3 1.0 4.4 2.1 0.3 -1.1 0.8 -0.8 0.6 -1.2 0.2 0.9 0.4
Arm predicted mass (right) 0.2 1.1 2.8 0.3 0.4 -1.6 -1.2 0.2 1.7 -0.6 0.6 -1.0 -1.3
Pulse rate, automated reading 1.2 3.7 7.6 1.3 2.1 -1.6 -2.2 1.5 2.5 -0.8 1.6 -2.3 -2.8
Alcohol intake frequency. 1.0 2.4 4.7 1.9 0.2 -1.4 -1.7 0.7 2.1 -0.3 1.4 -2.0 -2.2
Comparative height size at age 10 0.3 1.7 4.1 -0.7 -1.5 0.5 1.1 -1.2 -1.4 0.3 -2.0 1.2 1.9
Number of full sisters 0.2 0.3 1.7 0.2 0.1 0.3 -0.0 0.5 0.0 0.5 1.3 -0.4 -0.3
Suffer from ‘nerves’ 0.4 0.6 2.6 -0.3 -0.0 0.7 -0.2 -0.7 -1.6 -0.3 -1.6 -0.4 0.2
Overall health rating 0.4 0.9 2.9 1.7 0.3 0.7 -1.0 0.2 1.0 0.4 -0.8 -1.3 -0.7
Chest pain or discomfort 0.5 0.7 1.4 -0.4 0.7 -1.1 -1.2 0.4 0.1 -0.7 0.7 -0.9 -1.2
Had major operations 0.4 0.4 1.6 -0.1 -0.8 0.1 0.6 -0.7 0.5 -0.6 -1.3 -0.8 0.2
Age at last live birth 0.3 0.5 1.3 -1.0 0.9 0.2 0.0 0.7 -1.1 0.9 -0.2 0.6 0.4
Family relationship satisfaction 0.8 1.0 2.5 -0.8 0.9 -1.6 -1.5 1.0 0.7 -0.4 -0.1 -0.9 -1.1
Leg pain on walking 1.3 1.6 4.7 2.2 1.4 -0.7 -1.5 0.7 1.9 -0.4 0.0 -0.9 -1.3
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 2.9 0.2 -0.6 -1.5 -0.0 -0.6 -0.0 -1.7 -0.1 -0.5 -0.5
Commuting to job workplace: Car/motor vehicle 0.7 0.8 2.4 -1.4 0.5 -0.2 0.3 0.9 1.3 0.4 1.6 0.5 0.0
Illness, injury, bereavement, stress in last 2 years 1.2 1.4 2.5 1.3 -1.6 0.4 1.2 -1.6 -0.7 -0.6 -1.4 1.0 1.4
Medication: Aspirin 1.5 2.0 5.3 0.1 -1.1 -2.3 -0.6 -1.1 -0.4 -2.2 -1.1 -2.0 -1.4
Supplements: Vitamin C 0.4 0.4 2.3 0.1 -0.5 0.7 -0.0 0.3 1.5 -0.1 -0.9 0.1 0.4
Knee pain experienced in last month 0.9 1.4 2.8 1.0 1.4 -1.0 -1.6 0.2 1.2 -0.8 -0.8 -1.7 -1.4
Hypertension (Self-reported) 1.2 3.2 7.0 2.6 1.8 0.1 -2.6 1.6 1.5 -0.4 2.1 -1.2 -2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.4 4.0 0.5 -1.0 -0.1 2.0 -1.3 -0.7 -0.4 -1.4 1.2 1.7
Illnesses of father: Heart disease 1.0 1.3 4.9 1.1 0.1 0.3 -1.0 0.7 1.6 -0.9 2.2 -0.7 -1.2
Illnesses of siblings: Diabetes 0.4 0.5 2.6 1.6 -0.8 -0.4 0.2 -0.9 -0.6 -0.4 -0.3 -0.2 -0.1
Smoking status: Previous 0.3 0.5 1.2 0.2 -0.9 0.9 0.4 -1.1 -0.6 0.4 -0.8 -0.1 0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 4.9 -0.7 0.2 -2.2 -1.4 0.1 0.6 -0.8 0.3 -2.1 -2.1
Whole body fat-free mass 0.2 0.9 2.7 0.2 0.1 -1.6 -1.0 0.1 1.4 -0.9 0.4 -0.9 -1.1
Leg fat-free mass (right) 0.2 0.9 2.7 0.2 -0.1 -1.6 -0.9 -0.4 1.1 -1.2 0.2 -1.0 -1.1
Arm fat percentage (left) 0.2 0.8 3.2 1.8 -0.1 -0.7 1.0 -0.8 0.4 -1.2 -0.0 0.9 0.6
Average weekly red wine intake 2.3 3.4 9.4 0.4 -1.3 3.1 2.5 -0.3 -0.1 1.6 -0.0 2.5 2.8
Handedness (chirality/laterality): Left-handed 0.3 0.3 1.1 0.2 0.4 -0.6 -0.6 -0.2 -0.0 -0.2 -1.0 -0.9 -0.7
Mood swings 0.7 1.3 4.2 0.7 1.6 0.6 -0.1 0.9 1.2 2.0 1.2 1.1 0.3
Loneliness, isolation 0.3 0.5 1.4 0.9 -1.1 0.2 0.1 -1.2 -0.9 0.6 0.1 -0.3 -0.0
Long-standing illness, disability or infirmity 0.6 1.0 3.2 1.8 0.3 -0.6 -1.7 0.1 0.8 -0.6 -0.4 -1.0 -1.1
Ever had bowel cancer screening 0.6 0.7 2.2 -1.0 0.2 -0.6 -1.1 -0.4 -0.8 -1.5 -0.6 -0.6 -0.6
Diabetes diagnosed by doctor 0.2 0.4 0.8 0.9 0.3 -0.5 -0.9 -0.2 0.4 -0.8 -0.7 -0.5 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.5 1.2 -1.0 0.3 -1.1 -0.7 -0.5 -0.5 -0.9 -0.7 -0.5 -0.4
Friendships satisfaction 0.3 0.3 1.2 -1.1 0.7 -0.3 0.1 0.5 -0.2 0.9 -0.5 0.2 0.4
Qualifications: nursing, teaching 0.3 0.4 1.0 0.3 -0.9 0.0 1.0 -0.7 -0.8 -0.2 -0.5 0.3 0.8
Commuting to job workplace: Walk 0.7 0.8 2.1 1.5 -0.7 1.2 0.6 -0.7 -0.7 0.7 -0.6 0.7 1.0
Eye problems/disorders: Cataract 1.5 1.8 3.4 1.0 0.8 -1.8 -1.6 0.9 1.5 -1.1 0.5 -1.5 -1.8
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.5 0.3 1.2 0.3 -1.1 0.6 -0.4 0.6 0.4 -0.5 -0.8
Medication for cholesterol 0.4 0.6 1.7 -0.7 -0.1 0.5 1.1 0.4 -0.8 0.7 0.1 1.3 1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.2 2.6 4.9 1.8 1.0 -1.1 -1.6 1.5 2.2 -0.7 1.4 -2.0 -2.1
Back pain experienced in last month 0.6 0.9 3.2 1.8 0.7 -0.2 -1.2 0.8 1.1 0.2 -0.6 -1.0 -0.8
Mineral and other dietary supplements 2.3 3.0 6.5 -1.1 -2.4 0.6 2.2 -2.5 -2.0 -0.4 -1.8 0.9 1.9
Breast cancer (self-reported) 0.8 1.0 2.3 -0.8 1.0 -1.3 -1.5 1.4 0.6 -0.1 -0.5 -0.7 -1.0
Asthma (self-reported) 1.1 2.3 12.7 3.6 1.6 0.6 -1.1 1.5 0.6 0.8 1.3 -0.3 -0.9
Osteoporosis (self-reported) 0.2 0.2 1.1 0.9 -0.3 0.1 0.2 -0.4 -1.1 -0.3 0.0 -0.1 0.1
Osteoarthritis (self-reported) 0.3 0.4 1.0 -0.4 0.0 -0.9 -1.0 -0.7 0.4 -0.3 -0.1 -0.9 -0.8
Medication: Aspirin 1.7 2.2 6.2 0.2 -0.9 -2.5 -0.9 -0.9 -0.6 -2.1 -1.2 -2.3 -1.6
Medication: Gliclazide 0.2 0.2 0.5 0.1 0.6 0.6 -0.1 0.5 0.2 0.5 0.1 0.7 0.4
Illnesses of father: None of the above (group 1) 0.5 0.7 2.1 -0.8 1.1 0.9 0.2 0.9 -0.1 1.4 -1.0 -0.2 0.3
Smoking status: Current 0.4 0.6 2.8 -0.0 0.5 -0.7 -1.2 0.5 1.7 -0.1 -0.3 -0.6 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.3 1.0 -0.6 0.3 0.1 0.4 0.5 0.4 0.3 0.7 1.0 0.5
Whole body water mass 0.1 0.9 2.3 0.3 0.3 -1.5 -1.0 0.2 1.5 -0.7 0.5 -0.8 -1.1
Leg predicted mass (right) 0.2 1.0 3.2 0.2 -0.2 -1.8 -1.0 -0.4 1.1 -1.3 0.2 -1.1 -1.2
Arm fat mass (left) 0.2 0.8 3.0 1.7 0.2 -1.2 0.4 -0.7 1.0 -1.4 0.3 0.4 0.0
Number of self-reported non-cancer illnesses 0.7 1.2 10.1 3.2 -0.7 0.3 -0.2 -0.5 -0.1 -0.9 0.2 0.1 0.0
Average weekly champagne plus white wine intake 1.1 1.6 4.2 -2.0 -0.5 0.2 1.4 -0.3 -1.4 0.2 -2.0 0.9 1.5
Miserableness 0.7 1.3 3.6 1.5 1.0 1.3 0.3 0.5 0.8 1.9 1.1 1.1 0.7
Guilty feelings 0.5 0.8 2.2 -0.6 0.8 1.5 0.4 0.2 -0.8 1.2 0.2 1.3 1.0
Wears glasses or contact lenses 2.5 2.9 6.2 0.2 -2.4 0.1 2.1 -2.5 -1.7 -0.6 -2.1 1.0 1.9
Ever taken oral contraceptive pill 1.0 1.2 3.3 -0.3 0.6 1.8 1.2 0.5 -0.4 1.8 -0.0 1.1 1.2
Hearing aid user 1.1 1.2 3.1 1.8 -1.0 -0.3 1.4 -0.5 -1.2 -0.2 -0.9 1.4 1.3
Mother’s age at death 0.5 0.6 4.2 -2.1 1.2 0.3 -0.4 0.3 -0.5 0.4 -0.1 -0.0 -0.1
Financial situation satisfaction 0.5 0.6 2.4 0.3 0.2 -1.6 -0.8 -0.8 -0.4 -0.3 -1.2 -0.7 -0.4
Tinnitus: Yes, now most or all of the time 0.9 1.1 2.4 0.8 1.6 0.2 -1.2 1.5 1.5 1.0 0.7 -0.1 -0.6
Commuting to job workplace: Public transport 0.9 1.0 3.3 -0.0 0.1 -0.6 -1.8 -0.2 0.5 -0.9 -0.6 -1.6 -1.5
Eye problems/disorders: Glaucoma 1.6 1.9 4.2 0.3 -0.3 -1.8 -1.5 -0.6 -1.3 -2.0 -0.6 -2.0 -1.7
Medication: Blood pressure 0.3 0.7 2.3 1.5 0.3 0.5 -1.2 0.2 1.3 0.0 0.7 -0.2 -0.5
Pain type(s) experienced in last month: Hip pain 1.4 1.7 5.9 1.8 2.4 0.1 -1.2 1.6 1.1 1.0 1.1 0.9 -0.3
Supplements: Fish oil (including cod liver oil) 3.0 3.9 7.9 1.2 1.9 -2.3 -2.5 2.1 1.8 -0.6 1.5 -2.1 -2.8
High cholesterol (Self-reported) 0.4 0.7 2.4 -0.1 -0.8 -1.3 -0.3 -1.1 0.0 -1.5 -0.9 -0.4 -0.4
Medication: Bendroflumethiazide 0.2 0.3 1.3 1.1 0.2 -0.1 -0.8 -0.1 0.8 -0.5 0.4 -0.2 -0.5
Medication: Paracetamol 1.0 1.5 3.0 1.7 1.5 1.0 -0.7 1.4 1.7 1.1 1.2 0.9 0.0
Medication: Lisinopril 1.0 1.3 2.5 1.3 -1.3 -1.4 -0.6 -1.6 0.1 -1.5 -0.9 -1.1 -0.6
Medication: Atorvastatin 1.6 2.0 5.3 0.5 0.9 0.1 -1.5 2.1 2.3 0.9 1.7 -0.9 -1.6
Illnesses of father: High blood pressure 0.4 0.5 2.6 -1.6 0.1 -0.9 -0.0 -0.4 0.3 -0.8 1.0 0.4 -0.1
Alcohol drinker status: Never 1.0 1.2 2.9 1.3 0.3 -0.6 -1.2 0.2 1.2 -1.0 0.7 -1.7 -1.7
Ever smoked 0.4 0.8 2.0 0.2 -0.5 -0.9 -0.7 -1.0 -0.3 -1.1 -1.4 -1.2 -0.6
Basal metabolic rate 0.1 0.8 2.5 0.5 0.1 -1.6 -0.8 -0.1 1.4 -0.9 0.4 -0.6 -0.9
Leg fat percentage (left) 0.4 1.3 6.0 2.5 0.6 -1.4 0.9 -0.7 0.7 -1.5 0.3 0.8 0.3
Arm fat-free mass (left) 0.2 1.3 3.8 1.1 0.9 -1.5 -1.1 0.4 1.9 -0.7 0.9 -0.7 -1.2
Number of operations (self-reported) 0.6 0.9 4.1 -2.0 -0.6 0.3 0.4 -0.4 0.1 -1.6 -0.8 -1.1 -0.2
Average weekly beer plus cider intake 1.1 1.6 3.9 -1.1 1.4 -1.1 -1.5 1.2 0.1 0.3 2.0 -1.0 -1.7
Irritability 1.6 2.8 6.4 -2.5 -0.6 1.0 1.8 -0.4 -2.0 1.2 -1.8 1.8 2.1
Risk taking 0.6 0.8 2.4 -1.6 1.4 0.2 -0.4 1.1 0.7 0.5 0.5 -0.7 -0.8
Ever had prostate specific antigen (PSA) test 0.7 0.8 1.9 -0.7 0.6 -0.8 -0.9 0.8 1.4 -0.0 1.2 -0.9 -1.2
Fractured/broken bones in last 5 years 0.5 0.7 2.2 -0.0 0.3 -1.5 -0.5 0.0 1.1 -0.8 1.0 -0.5 -0.9
Age started oral contraceptive pill 0.6 0.7 1.7 0.5 -0.8 0.8 0.9 -0.7 -0.8 0.7 -0.3 1.3 1.3
Diastolic blood pressure, automated reading 2.3 7.1 18.3 -1.2 3.4 0.7 -1.6 4.0 3.1 2.9 4.3 -0.2 -1.6
Ever depressed for a whole week 0.3 0.4 1.7 -0.7 0.1 -0.5 -0.8 -0.2 -0.4 0.0 -1.3 -0.8 -0.2
Unable to work because of sickness or disability 1.6 2.1 3.5 1.4 1.9 0.7 -1.9 1.8 1.9 1.6 0.2 -0.9 -1.1
Commuting to job workplace: Cycle 2.9 3.5 8.9 0.2 -1.9 -2.3 -0.8 -2.5 -1.7 -3.0 -2.0 -1.7 -0.7
Myopia 0.9 1.2 3.2 -0.3 -0.7 1.0 1.3 -0.8 -1.2 0.5 -1.8 1.1 1.6
Vascular/heart problems diagnosed by doctor 0.8 2.2 6.7 -2.6 -1.1 -0.3 2.0 -0.9 -1.5 0.4 -1.5 1.1 1.7
Cholesterol lowering medication 0.5 0.7 2.2 0.2 -0.9 -0.6 -0.5 -0.8 0.7 -1.5 -1.1 -0.8 -0.5
Medication: Omeprazole (e.g. Zanprol) 0.4 0.4 2.0 1.4 -0.4 0.1 0.9 -0.5 -0.4 0.8 -0.3 -0.3 0.5
Pain experienced in last month 1.3 2.1 5.6 -2.1 -1.9 0.4 1.7 -1.2 -2.4 -0.2 -0.0 1.0 1.3
Supplements: Calcium 0.2 0.2 0.8 0.3 0.0 0.9 -0.8 -0.3 0.5 0.2 -0.3 -0.1 0.0
Basal cell carcinoma (self-reported) 1.0 1.2 3.8 0.6 -1.1 -0.9 0.4 -1.9 -1.2 -0.7 -1.8 0.1 0.8
Heart attack/myocardial infarction (self-reported) 1.1 1.4 3.0 1.2 -1.7 1.0 1.1 -1.3 -0.4 0.7 -1.7 0.8 1.4
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.2 -0.2 -1.1 0.6 0.6 -0.9 0.3 -0.5 0.9 -0.2 -0.2
Heart disease (siblings) 0.7 0.9 5.3 2.3 -0.6 0.8 0.7 0.8 0.4 0.8 0.4 0.5 0.5
Alcohol drinker status: Previous 0.7 0.8 3.3 1.0 0.5 1.0 -0.1 0.7 1.4 1.8 0.5 0.2 0.1
Pack years of smoking 0.5 0.7 3.5 1.9 0.7 0.1 -0.8 0.1 0.7 0.6 -0.2 -0.8 -0.8
Impedance of whole body 0.3 1.8 4.1 0.5 -0.5 1.4 1.5 -0.9 -1.8 0.6 -1.5 1.5 2.0
Leg fat mass (left) 0.3 1.2 5.1 2.2 0.2 -1.4 0.7 -0.9 0.6 -1.5 0.1 0.6 0.3
Arm predicted mass (left) 0.2 1.2 3.0 1.0 0.6 -1.6 -1.1 0.2 1.7 -0.9 0.7 -0.8 -1.2