Hub : Genes

ACN9

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Skin Not Sun Exposed Suprapubic 0.1940 0.0700 0.0016 0.099 NA 0.031 NA 0.061 4.7e-06 NA 0.0081 NA 0.00029
2 NTR Blood 0.0193 0.0079 0.0017 -0.001 0.005 -0.001 0.004 0.000 6.0e-01 0.0094 0.8900 0.014 0.48000

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.1 1.8 3.5 0.1 -1.9
Bipolar Disorder or Schizophrenia 1.3 3.2 5.3 -1.0 -2.3
Depressed Affect (Nagel 2018) 2.4 5.0 7.3 -1.6 -2.7
Depression (Nagel 2018) 0.1 0.2 0.2 0.3 -0.5
Intelligence (Savage-Jansen 2018) 0.3 0.9 1.6 -1.3 0.3
Neuroticism (Nagel 2018) 2.6 6.2 10.5 -1.4 -3.2
Schizophrenia (2018) 1.0 2.0 2.0 -1.4 -1.4
Schizophrenia vs Biploar Disorder 0.7 1.0 1.8 -1.4 0.3
Worry (Nagel 2018) 1.4 2.9 5.4 -0.6 -2.3
Alzheimer’s Disease (in mother) 1.3 1.5 2.6 -0.6 -1.6
Alzheimer’s Disease (in father) 3.2 3.4 6.4 -2.5 -0.7
Alzheimer’s Disease (including proxy) 0.9 1.4 2.4 -1.5 -0.6
Crohns Disease (2017) 0.1 0.2 0.4 -0.1 0.6
Irritable Bowel Disease (IBD) 0.3 0.7 1.1 1.0 0.5
Ulcerative Colitis (UC) 0.4 0.7 1.3 1.1 0.3
Major Depression (MDD) 0.7 0.9 0.9 -1.0 -0.9
Reaction Time 0.4 0.8 1.2 -1.1 0.6
Verbal and Numeric Reasoning (VNR) 1.3 3.0 5.8 0.5 2.4
Breast Cancer 0.4 1.1 2.1 -1.5 0.2
Ovarian Cancer 0.1 0.1 0.3 -0.5 0.1
Prostate Cancer 1.0 1.4 2.1 1.4 0.8
Age at First Birth 0.3 0.5 0.8 -0.9 -0.3
Bipolar Disorder (2011) 0.3 0.3 0.5 -0.2 -0.7
Body Mass Index (BMI) (2010) 0.3 0.4 0.8 -0.0 -0.9
Coronary Artery Disease (CAD) 2.2 2.7 3.7 -1.3 -1.9
Crohns Disease (2012) 0.1 0.2 0.2 0.5 0.5
Mean Putamen Volume 1.9 2.2 3.8 -0.8 -1.9
Fasting Glucose 0.5 0.6 1.2 -0.2 -1.1
HbA1C 0.6 0.7 0.7 0.8 -0.8
HDL Cholesterol 0.2 0.3 0.4 0.7 0.4
LDL Cholesterol 0.1 0.2 0.3 0.6 0.2
Lupus 0.0 0.1 0.1 -0.3 0.2
Neuroticism (2016) 4.2 6.1 8.4 -2.9 -1.9
Primary Biliary Cirrhosis 0.5 0.7 1.3 1.1 -0.1
Rheumatoid Arthritis 0.3 0.5 0.9 -0.1 1.0
Schizophrenia (2014) 1.8 4.0 6.3 -1.3 -2.5
Triglycerides 0.3 0.5 1.0 -1.0 0.1
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.1 0.0 -0.3
Ulcerative Colitis 0.5 0.7 1.0 1.0 0.6
Blood Eosinophil Count 0.3 2.2 4.4 0.2 2.1
Blood Platelet Count 0.1 1.4 2.2 0.7 -1.5
Blood Red Count 0.1 0.8 1.4 -1.2 -0.3
Blood White Count 0.0 0.0 0.0 0.1 -0.0
Heel T-Score 4.7 37.6 69.7 -8.3 2.4
BMI 0.0 0.2 0.3 -0.1 0.5
Height 0.3 5.3 10.2 -3.2 0.7
Waist Hip Ratio (WHR) 0.6 2.6 5.0 -0.4 -2.2
Systolic Blood Pressure 0.6 3.2 5.2 -1.1 -2.3
Smoking Status 2.3 5.4 9.7 -3.1 -1.1
Allergy or Eczema 1.3 3.4 3.8 1.9 1.7
Cardiovascular Disease 1.1 3.5 6.2 -0.9 -2.5
Hypothyroidism (self reported) 0.5 1.2 2.0 -1.4 -0.6
Respiratory disease 0.8 1.8 2.2 1.5 1.2
Type 2 Diabetes (T2D) (2018) 0.2 0.3 0.7 0.0 0.8
Lung FEV1/FVC ratio 0.2 1.2 1.8 -0.7 1.3
Lung FVC 1.1 5.4 8.2 2.9 -1.6
Neuroticism 2.5 6.0 11.2 -0.9 -3.4
Chronotype (morning person) 1.6 3.7 7.3 2.7 -0.4
Hair Pigment 0.0 0.3 0.6 0.3 -0.8
Tanning 0.2 2.9 5.5 -2.3 0.5
Hand grip strength (left) 0.7 1.9 2.0 1.3 1.4
Number of treatments/medications taken 0.1 0.2 0.5 0.7 -0.1
Average weekly spirits intake 0.7 0.9 1.3 -1.1 0.7
Sensitivity / hurt feelings 1.2 2.1 4.0 -0.3 -2.0
Frequency of depressed mood in last 2 weeks 0.7 1.0 1.5 0.7 -1.2
Hearing difficulty/problems: Yes 0.0 0.0 0.1 0.3 -0.0
Relative age of first facial hair 0.9 1.9 2.7 1.6 1.0
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 0.8 0.9 -0.2
Ever used hormone-replacement therapy (HRT) 0.2 0.3 0.6 0.1 0.8
Ever had hysterectomy (womb removed) 0.0 0.1 0.1 -0.3 -0.1
Systolic blood pressure, automated reading 0.2 0.5 0.8 -0.9 -0.4
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.3 -0.4 0.5
Angina 0.8 1.0 1.6 -0.7 -1.3
Medication for hormone replacement therapy 0.1 0.1 0.1 0.4 0.1
Vitamin and mineral supplements 0.8 1.1 1.3 -1.1 0.9
Supplements: Zinc 1.4 1.5 3.0 1.7 -0.1
Medication: Co-codamol 2.1 2.4 3.6 -1.9 -1.1
Medication: Metformin 0.2 0.3 0.5 -0.2 0.7
Diabetes (father) 0.2 0.2 0.4 -0.6 0.1
Diabetes (mother) 3.4 4.4 4.8 -2.0 -2.2
Severe depression (siblings) 1.0 1.2 2.2 0.3 -1.5
Pack years adult smoking proportion 0.5 0.8 1.3 0.4 -1.1
Impedance of leg (right) 2.0 9.5 13.7 -3.7 -2.3
Leg fat-free mass (left) 0.1 0.3 0.5 0.4 0.7
Trunk fat percentage 0.1 0.5 0.6 -0.8 -0.5
Hand grip strength (right) 0.4 1.1 1.7 1.3 0.7
Townsend deprivation index at recruitment 0.3 0.4 0.8 -0.9 -0.2
Current tobacco smoking 2.5 4.0 5.1 -1.7 -2.3
Average weekly fortified wine intake 1.3 1.5 3.1 1.8 -0.0
Maternal smoking around birth 2.5 3.7 5.9 -2.4 -1.2
Fed-up feelings 2.6 4.6 6.8 -1.6 -2.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 1.3 -0.3 -1.2
Relative age voice broke 0.1 0.2 0.3 0.6 -0.1
Taking other prescription medications 0.1 0.2 0.4 -0.0 -0.6
Age when periods started (menarche) 0.3 0.6 1.0 0.5 1.0
Bilateral oophorectomy (both ovaries removed) 0.9 1.1 1.3 1.1 0.9
Heel bone mineral density (BMD) T-score, automated (left) 1.8 4.1 7.8 -2.8 -0.5
Tinnitus: Yes, but not now, but have in the past 5.6 6.0 6.2 -2.5 -2.4
Qualifications: CSEs or equivalent 0.3 0.4 0.6 0.8 -0.5
Serious illness, injury or assault to yourself 0.1 0.1 0.2 0.0 0.5
High blood pressure 1.8 5.0 9.9 -0.3 -3.1
Hayfever, allergic rhinitis or eczema 2.4 5.2 7.5 2.7 1.7
Multivitamins +/- minerals 0.3 0.4 0.9 0.9 -0.1
Stomach or abdominal pain in last month 1.2 1.5 1.5 1.2 -1.2
Supplements: Glucosamine 0.4 0.5 1.0 -0.1 -1.0
Diverticular disease/diverticulitis (self-reported) 0.8 1.0 1.7 0.5 -1.3
Medication: Atenolol 0.6 0.7 1.3 -1.1 -0.4
Medication: Levothyroxine sodium 0.2 0.3 0.4 -0.7 -0.5
Sitting height 0.0 0.3 0.4 -0.3 0.7
Chronic bronchitis/emphysema (father) 0.5 0.6 1.1 1.1 -0.2
High blood pressure (mother) 1.8 2.5 4.6 -0.7 -2.1
Body mass index (BMI) 0.1 0.4 0.7 -0.8 -0.3
Impedance of leg (left) 2.2 10.7 15.1 -3.9 -2.5
Leg predicted mass (left) 0.0 0.2 0.4 0.3 0.6
Trunk fat mass 0.2 0.8 1.3 -1.1 -0.6
Waist circumference 0.5 1.8 2.5 -1.1 -1.6
Number of incorrect matches in round 0.3 0.6 1.0 -1.0 -0.4
Past tobacco smoking 0.6 1.2 1.8 1.3 -0.7
Alcohol usually taken with meals 0.4 0.6 1.1 0.4 1.1
Nervous feelings 0.3 0.6 1.3 -0.2 -1.1
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 1.6 0.2 -1.3
Hearing difficulty/problems with background noise 0.2 0.3 0.4 -0.4 -0.6
Hair/balding pattern: Pattern 2 0.8 1.0 1.3 0.9 1.1
Had menopause 0.1 0.1 0.2 0.2 0.4
Had other major operations 0.0 0.0 0.1 -0.2 -0.1
Forced vital capacity (FVC) 0.4 1.7 3.3 0.4 -1.8
Heel bone mineral density (BMD) T-score, automated (right) 1.7 3.9 7.8 -2.8 -0.0
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.1 1.1 0.5
Qualifications: None of the above 1.3 2.8 5.5 -2.4 0.2
Financial difficulties in last 2 years 1.2 1.6 3.1 0.1 -1.8
Mouth/teeth dental problems 0.6 1.0 2.0 -0.0 1.4
Heart attack 0.5 0.7 1.3 -1.1 -0.2
Allergy 1.3 3.0 3.8 -2.0 -1.4
Pain all over the body in last month 1.7 1.9 3.6 1.9 -0.4
Diabetes (self-reported) 0.5 0.7 1.2 -1.1 0.5
Hayfever/allergic rhinitis (self-reported) 1.8 2.3 2.4 1.5 1.6
Medication: Ramipril 0.2 0.3 0.4 -0.5 -0.6
Medication: Simvastatin 0.4 0.5 0.7 -0.6 0.8
Fluid intelligence score 0.6 1.3 2.3 0.5 1.5
Illnesses of siblings 1.5 2.2 2.8 1.7 1.2
Neuroticism score 2.3 4.9 8.8 -1.0 -3.0
Weight 0.2 1.2 1.9 -1.4 -0.7
Impedance of arm (right) 0.1 0.6 1.2 1.1 -0.0
Arm fat percentage (right) 0.0 0.2 0.3 -0.2 -0.6
Trunk fat-free mass 0.2 1.2 2.4 -1.6 -0.1
Hip circumference 0.3 1.5 2.3 -1.5 -0.8
Time employed in main current job 0.7 0.8 1.4 0.2 1.2
Alcohol intake versus 10 years previously 0.3 0.5 0.9 0.0 -1.0
Father’s age at death 3.7 4.9 8.4 1.2 2.9
Worrier / anxious feelings 1.7 3.3 4.8 -1.3 -2.2
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 0.7 0.5 -0.8
Falls in the last year 1.2 1.7 3.3 -0.2 -1.8
Hair/balding pattern: Pattern 3 0.2 0.3 0.5 -0.2 0.7
Number of live births 0.5 0.7 1.3 -0.5 -1.1
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 0.9 0.6 -1.0
Pulse rate 0.3 0.6 0.8 0.6 0.9
Happiness 0.3 0.4 0.5 0.7 0.5
Noisy workplace 2.4 3.0 3.6 -1.5 -1.9
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.4 -0.7 -0.1
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.2 1.4 1.2 1.0
Mouth/teeth dental problems: Dentures 0.2 0.3 0.6 0.8 -0.2
Asthma 1.0 1.9 2.9 1.0 1.7
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.2 -0.4 -0.0
Medication: Cholesterol lowering 0.3 0.4 0.7 -0.3 0.8
Depression (self-reported) 1.6 2.0 2.6 1.2 -1.6
Medication: Lansoprazole 1.2 1.4 1.6 -1.1 -1.3
Prospective memory result 0.2 0.2 0.5 -0.1 -0.7
Lung cancer (father) 0.6 0.8 1.5 -1.2 0.2
Illnesses of mother 1.4 1.7 2.3 1.0 1.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 2.0 3.5 0.6 -1.9
Pulse wave Arterial Stiffness index 1.4 1.6 3.2 -0.3 -1.8
Impedance of arm (left) 0.3 1.4 2.7 1.6 -0.2
Arm fat mass (right) 0.2 0.7 1.1 -1.1 -0.5
Trunk predicted mass 0.2 1.3 2.5 -1.6 -0.1
Standing height 0.2 1.9 3.3 -1.8 -0.7
Length of working week for main job 0.2 0.2 0.3 -0.6 -0.4
Exposure to tobacco smoke at home 0.3 0.4 0.6 0.5 -0.8
Breastfed as a baby 1.6 2.0 3.1 1.0 1.8
Tense / ‘highly strung’ 1.2 2.1 4.1 -0.2 -2.0
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.7 1.9 1.2 -1.4
Hair/balding pattern: Pattern 4 0.1 0.1 0.3 -0.5 -0.0
Birth weight of first child 0.0 0.0 0.1 0.3 -0.1
Peak expiratory flow (PEF) 0.4 1.0 1.3 0.8 1.1
Pulse wave reflection index 1.7 2.1 3.8 -0.7 -1.9
Ever highly irritable/argumentative for 2 days 2.2 2.7 4.9 -0.6 -2.2
Loud music exposure frequency 0.5 0.6 0.6 0.7 -0.8
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.0 -1.0 -0.1
Mouth/teeth dental problems: Bleeding gums 0.9 1.1 2.2 0.1 -1.5
Blood clot in the leg (DVT) 0.2 0.2 0.4 -0.2 0.6
Medication: Paracetamol 0.4 0.6 0.9 -0.6 -0.9
Headache pain in last month 0.5 0.8 1.7 -0.0 -1.3
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 0.4 0.6 0.6
Glaucoma (self-reported) 0.3 0.4 0.6 0.8 0.4
Gout (self-reported) 0.5 0.7 1.2 -1.1 0.5
Hypothyroidism/myxoedema (self-reported) 0.6 1.1 1.8 -1.3 -0.7
Medication: Amlodipine 1.3 1.8 3.1 1.8 -0.7
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.1 -0.1 0.4
Birth weight 0.7 1.5 2.3 0.9 1.5
Chronic bronchitis/emphysema (mother) 0.3 0.4 0.7 -0.8 -0.3
High blood pressure (siblings) 2.8 4.0 5.2 -1.7 -2.3
Forced vital capacity (FVC), Best measure 0.7 2.4 4.8 0.1 -2.2
Body fat percentage 0.4 1.4 1.6 -1.2 -1.1
Leg fat percentage (right) 1.4 5.0 5.7 -2.4 -2.1
Arm fat-free mass (right) 0.4 2.3 4.5 -2.1 -0.3
Exposure to tobacco smoke outside home 0.9 1.2 2.0 0.5 1.4
Comparative body size at age 10 0.9 2.4 3.5 1.9 1.2
Number of full brothers 0.1 0.1 0.1 -0.4 0.2
Worry too long after embarrassment 0.8 1.4 2.3 1.5 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.2 1.7 -0.8 -1.3
Wheeze or whistling in the chest in last year 0.0 0.1 0.1 -0.1 0.3
Number of children fathered 1.2 1.3 2.4 -0.4 -1.6
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.0 1.0 -0.2
Age at first live birth 0.4 0.7 1.1 -0.6 1.0
Pulse wave peak to peak time 1.2 1.4 2.9 0.1 1.7
Health satisfaction 0.6 0.8 1.5 0.2 -1.2
Shortness of breath walking on level ground 1.6 1.9 3.0 -1.7 -0.9
Qualifications: College or University degree 1.0 3.1 6.2 2.5 0.2
Eye problems/disorders: None of the above 1.6 1.9 3.1 -1.8 0.8
Mouth/teeth dental problems: Loose teeth 1.8 2.1 4.2 2.1 0.1
Emphysema/chronic bronchitis 0.2 0.2 0.3 -0.5 0.2
Medication for pain relief, constipation, heartburn 0.0 0.0 0.1 -0.1 0.3
Neck or shoulder pain in last month 0.2 0.3 0.6 0.2 -0.8
Medication: Blood pressure 0.5 0.9 1.5 -0.6 -1.2
Angina (self-reported) 0.7 1.0 1.5 -0.6 -1.2
Migraine (self-reported) 1.0 1.3 2.6 -1.6 0.0
Medication: Ibuprofen 0.3 0.3 0.6 -0.8 0.3
Medication: Allopurinol 2.0 2.7 3.8 -1.9 1.2
Medication: Omeprazole 0.4 0.5 0.6 -0.6 -0.8
Medication: Seretide 50 evohaler 1.4 1.6 2.6 1.6 0.7
Mean time to correctly identify matches 0.3 0.6 1.0 -0.5 1.0
Heart disease (mother) 0.1 0.1 0.1 0.3 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.4 0.6 0.1
Whole body fat mass 0.3 1.4 2.0 -1.4 -0.9
Leg fat mass (right) 0.7 2.8 3.9 -2.0 -1.3
Arm predicted mass (right) 0.4 1.9 3.7 -1.9 -0.2
Pulse rate, automated reading 0.5 1.6 1.9 1.2 1.4
Alcohol intake frequency. 0.2 0.4 0.7 0.0 -0.9
Comparative height size at age 10 0.1 0.4 0.7 -0.9 -0.1
Number of full sisters 0.2 0.3 0.3 -0.4 -0.6
Suffer from ‘nerves’ 1.4 2.1 4.1 -0.5 -2.0
Overall health rating 1.7 3.7 7.1 0.5 -2.7
Chest pain or discomfort 0.2 0.3 0.5 0.7 -0.3
Had major operations 1.4 1.6 3.2 0.2 1.8
Age at last live birth 1.0 1.4 2.7 -1.6 0.4
Family relationship satisfaction 0.3 0.3 0.5 0.4 0.7
Leg pain on walking 1.0 1.2 2.2 0.6 -1.5
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 0.6 -0.6 -0.8
Commuting to job workplace: Car/motor vehicle 1.3 1.5 2.7 1.6 0.5
Illness, injury, bereavement, stress in last 2 years 0.7 0.8 1.2 -0.6 1.1
Medication: Aspirin 0.0 0.0 0.0 0.0 0.2
Supplements: Vitamin C 1.5 1.8 3.0 0.7 -1.7
Knee pain experienced in last month 0.5 0.8 1.6 -0.1 -1.3
Hypertension (Self-reported) 1.4 4.0 8.0 -0.1 -2.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.7 2.0 3.9 -0.2 -2.0
Illnesses of father: Heart disease 0.1 0.1 0.2 -0.3 0.5
Illnesses of siblings: Diabetes 1.2 1.5 1.9 -1.4 -1.1
Smoking status: Previous 1.7 2.5 4.3 -2.1 0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 1.4 -1.2 -1.2
Whole body fat-free mass 0.1 0.5 1.0 -1.0 0.2
Leg fat-free mass (right) 0.1 0.5 0.7 0.5 0.9
Arm fat percentage (left) 0.1 0.3 0.6 0.1 -0.7
Average weekly red wine intake 0.0 0.0 0.0 -0.1 0.1
Handedness (chirality/laterality): Left-handed 0.3 0.3 0.5 0.7 -0.3
Mood swings 1.3 2.4 4.2 -0.8 -2.1
Loneliness, isolation 2.6 3.7 6.8 -0.7 -2.6
Long-standing illness, disability or infirmity 2.0 3.0 4.5 -1.3 -2.1
Ever had bowel cancer screening 0.5 0.5 0.9 1.0 0.4
Diabetes diagnosed by doctor 0.4 0.7 0.9 -0.9 0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 0.7 -0.9 -0.3
Friendships satisfaction 0.7 0.9 1.7 1.3 0.3
Qualifications: nursing, teaching 0.4 0.7 0.9 0.9 -0.7
Commuting to job workplace: Walk 0.2 0.2 0.3 -0.1 -0.6
Eye problems/disorders: Cataract 1.5 1.7 2.4 1.5 -1.0
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 1.0 1.0 -0.6
Medication for cholesterol 0.8 1.2 1.3 -1.1 1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.2 -0.4 -0.1
Back pain experienced in last month 1.0 1.4 2.7 -1.7 0.2
Mineral and other dietary supplements 0.5 0.6 0.8 -0.7 0.9
Breast cancer (self-reported) 1.4 1.7 3.2 0.4 1.8
Asthma (self-reported) 0.9 1.8 2.6 1.0 1.6
Osteoporosis (self-reported) 1.5 1.8 2.4 1.1 -1.6
Osteoarthritis (self-reported) 0.8 1.0 1.7 -0.5 -1.3
Medication: Aspirin 0.0 0.0 0.1 -0.3 0.0
Medication: Gliclazide 1.1 1.3 2.5 0.2 1.6
Illnesses of father: None of the above (group 1) 0.4 0.6 0.6 -0.7 0.8
Smoking status: Current 1.8 2.9 4.0 -1.3 -2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 1.7 -0.0 -1.3
Whole body water mass 0.1 0.5 0.9 -1.0 0.2
Leg predicted mass (right) 0.1 0.6 0.8 0.6 0.9
Arm fat mass (left) 0.1 0.3 0.4 -0.4 -0.6
Number of self-reported non-cancer illnesses 0.0 0.0 0.0 0.1 -0.1
Average weekly champagne plus white wine intake 0.4 0.5 0.7 0.5 0.8
Miserableness 3.0 5.1 8.1 -1.5 -2.9
Guilty feelings 0.3 0.4 0.7 0.9 -0.4
Wears glasses or contact lenses 0.1 0.1 0.2 0.5 0.1
Ever taken oral contraceptive pill 1.0 1.2 1.4 -1.0 -1.2
Hearing aid user 1.4 1.6 2.4 -1.5 -0.9
Mother’s age at death 0.2 0.3 0.5 0.2 -0.7
Financial situation satisfaction 0.4 0.5 1.0 0.0 -1.0
Tinnitus: Yes, now most or all of the time 0.3 0.3 0.3 -0.6 -0.5
Commuting to job workplace: Public transport 0.6 0.7 1.4 -1.2 0.1
Eye problems/disorders: Glaucoma 0.2 0.3 0.3 0.5 0.5
Medication: Blood pressure 1.2 2.2 4.0 0.7 -2.0
Pain type(s) experienced in last month: Hip pain 0.3 0.4 0.5 -0.5 -0.7
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.5 0.2 -0.7
High cholesterol (Self-reported) 0.8 1.4 1.8 -1.0 -1.3
Medication: Bendroflumethiazide 1.7 2.6 5.1 -0.3 -2.3
Medication: Paracetamol 0.6 0.9 0.9 -1.0 -0.9
Medication: Lisinopril 0.0 0.0 0.1 0.3 -0.1
Medication: Atorvastatin 0.4 0.4 0.5 -0.7 -0.6
Illnesses of father: High blood pressure 1.1 1.4 2.1 0.8 -1.4
Alcohol drinker status: Never 1.1 1.3 1.7 1.0 1.3
Ever smoked 0.3 0.6 0.8 -0.6 0.9
Basal metabolic rate 0.1 0.6 1.1 -1.1 -0.0
Leg fat percentage (left) 1.4 5.1 5.9 -2.4 -2.1
Arm fat-free mass (left) 0.5 2.5 4.8 -2.2 -0.4
Number of operations (self-reported) 0.3 0.4 0.7 -0.4 -0.8
Average weekly beer plus cider intake 0.1 0.1 0.2 -0.5 -0.3
Irritability 1.4 2.3 3.1 -1.2 -1.8
Risk taking 0.1 0.2 0.3 -0.5 -0.2
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.4 0.6 -0.0
Fractured/broken bones in last 5 years 4.4 5.7 11.3 -0.1 -3.4
Age started oral contraceptive pill 1.4 1.7 3.3 -0.4 1.8
Diastolic blood pressure, automated reading 0.9 2.8 4.8 -0.8 -2.2
Ever depressed for a whole week 0.7 0.9 1.8 0.1 -1.3
Unable to work because of sickness or disability 0.5 0.7 1.3 -0.1 -1.2
Commuting to job workplace: Cycle 0.8 1.0 2.0 -0.0 -1.4
Myopia 0.4 0.6 1.2 -0.3 1.1
Vascular/heart problems diagnosed by doctor 1.6 4.3 8.5 0.4 2.9
Cholesterol lowering medication 0.5 0.7 1.3 0.3 -1.2
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 1.3 -0.6 -1.1
Pain experienced in last month 1.1 1.8 2.5 1.0 1.6
Supplements: Calcium 0.8 0.9 1.4 0.6 -1.2
Basal cell carcinoma (self-reported) 2.7 3.2 3.2 1.8 -1.8
Heart attack/myocardial infarction (self-reported) 0.7 0.8 1.6 -1.3 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.0 0.1 0.1 -0.2 0.3
Heart disease (siblings) 1.2 1.4 2.8 -1.7 0.3
Alcohol drinker status: Previous 0.1 0.1 0.2 -0.0 -0.4
Pack years of smoking 0.5 0.7 0.9 0.7 -0.9
Impedance of whole body 0.3 1.4 1.6 -1.0 -1.3
Leg fat mass (left) 0.8 3.2 4.4 -2.1 -1.4
Arm predicted mass (left) 0.5 2.4 4.7 -2.2 -0.2