Hub : Genes

ACOT7

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.1720 0.0420 3.1e-06 0.156 NA 0.112 NA 0.156 9.4e-13 NA 2.1e-09 NA 9.6e-13
2 GTEx Breast Mammary Tissue (Male) 0.3004 0.1282 5.7e-03 0.042 NA 0.042 NA 0.062 3.9e-02 NA 4.0e-02 NA 1.5e-02
3 GTEx Muscle Skeletal 0.1326 0.0390 1.2e-04 0.064 NA 0.064 NA 0.068 6.3e-07 NA 6.4e-07 NA 2.9e-07
4 GTEx Skin Not Sun Exposed Suprapubic 0.1170 0.0500 1.6e-03 0.011 NA -0.005 NA 0.015 7.5e-02 NA 7.4e-01 NA 4.9e-02
5 GTEx Skin Sun Exposed Lower leg 0.2410 0.0580 3.1e-08 0.061 NA 0.085 NA 0.082 8.1e-06 NA 1.7e-07 NA 2.5e-07
6 GTEx Testis 0.1680 0.0690 1.8e-03 0.037 NA 0.025 NA 0.020 8.9e-03 NA 2.7e-02 NA 4.3e-02
7 METSIM Adipose 0.1151 0.0265 2.7e-15 0.142 0.120 0.138 0.133 0.134 1.4e-20 1.7e-17 4.5e-20 2.5e-19 1.7e-19
8 ROSMAP Brain Pre-frontal Cortex 0.0524 0.0225 2.9e-03 -0.002 0.007 -0.002 0.008 -0.002 7.0e-01 4.2e-02 9.9e-01 2.5e-02 6.5e-01
9 TCGA Prostate Adenocarcinoma 0.0444 0.0258 2.8e-03 0.030 0.017 0.026 NA 0.021 3.4e-04 5.7e-03 8.3e-04 NA 2.3e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 4.8 7.6 14.3 -2.7 -3.2 -2.4 -3.4 -1.4 2.3 -3.8 1.8 -2.9
Bipolar Disorder or Schizophrenia 3.0 7.2 21.5 -2.2 -2.7 -2.0 -4.6 -1.8 2.1 -3.4 1.6 -2.4
Depressed Affect (Nagel 2018) 1.5 3.2 10.6 1.9 1.3 1.4 1.7 1.4 -1.5 1.6 -3.2 1.4
Depression (Nagel 2018) 0.4 0.7 4.2 0.5 0.1 0.5 -0.6 0.3 -0.9 0.3 -2.1 0.3
Intelligence (Savage-Jansen 2018) 0.6 2.0 6.2 1.3 0.0 0.6 2.3 2.5 -1.5 0.8 0.8 0.8
Neuroticism (Nagel 2018) 2.8 6.6 8.2 2.7 2.9 2.2 2.4 2.4 -2.5 2.8 -2.7 2.5
Schizophrenia (2018) 0.8 1.6 8.6 -0.7 -0.8 -0.5 -2.9 -1.1 0.9 -1.2 0.6 -0.8
Schizophrenia vs Biploar Disorder 0.3 0.4 1.3 1.1 0.3 0.9 -0.0 0.5 -0.1 0.7 -0.6 0.7
Worry (Nagel 2018) 2.4 5.1 8.3 2.2 2.2 2.6 1.9 1.6 -2.2 2.9 -1.8 2.7
Alzheimer’s Disease (in mother) 0.8 0.9 2.9 1.7 0.5 1.0 0.3 0.8 -0.6 1.0 -0.7 1.2
Alzheimer’s Disease (in father) 0.2 0.3 1.1 -0.6 0.6 -0.2 -0.2 -0.2 -1.0 -0.3 0.5 -0.0
Alzheimer’s Disease (including proxy) 0.2 0.3 0.9 1.0 0.5 0.5 -0.3 0.1 -0.7 0.3 -0.7 0.7
Crohns Disease (2017) 2.3 5.0 10.4 -1.7 -1.6 -2.1 -2.2 -2.0 3.2 -2.5 2.1 -2.3
Irritable Bowel Disease (IBD) 2.7 6.4 16.6 -1.8 -1.8 -2.0 -3.2 -2.4 4.1 -2.4 2.2 -2.0
Ulcerative Colitis (UC) 1.8 3.4 9.2 -1.4 -1.1 -1.3 -2.9 -2.0 3.0 -1.4 1.2 -1.1
Major Depression (MDD) 0.4 0.5 1.6 0.9 0.0 0.8 -1.3 0.3 0.9 0.3 -0.9 0.0
Reaction Time 0.4 0.8 3.6 -0.1 -0.1 -0.1 -0.9 -1.9 0.5 -0.4 -1.4 -0.5
Verbal and Numeric Reasoning (VNR) 0.4 1.1 3.2 0.4 -0.1 0.2 1.8 1.1 -1.3 0.4 1.7 0.4
Breast Cancer 0.9 2.2 4.9 1.8 1.4 2.2 0.3 1.3 0.2 1.5 -0.9 2.1
Ovarian Cancer 0.2 0.3 0.8 -0.5 0.4 -0.7 -0.2 0.4 -0.1 -0.2 0.9 -0.7
Prostate Cancer 0.2 0.3 0.8 -0.8 -0.3 -0.5 -0.0 -0.8 -0.5 0.2 0.9 -0.3
Age at First Birth 0.7 1.1 3.7 0.7 0.9 1.4 -0.3 0.0 -0.6 1.9 0.4 1.4
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.4 0.6 2.3 0.5 0.9 0.5 1.5 -0.1 -0.6 0.5 -0.5 0.8
Coronary Artery Disease (CAD) 0.2 0.2 0.7 -0.2 -0.9 -0.2 0.8 0.6 -0.0 -0.3 0.5 0.0
Crohns Disease (2012) 3.4 5.5 11.3 -1.6 -2.0 -2.1 -2.3 -2.4 3.4 -2.4 2.3 -2.1
Mean Putamen Volume 3.3 3.8 5.8 -2.3 -2.2 -2.4 -2.0 -1.0 1.1 -2.0 1.8 -2.2
Fasting Glucose 0.7 0.8 1.7 0.6 1.3 0.9 0.2 -0.3 -0.8 1.1 -0.7 1.3
HbA1C 4.9 5.5 10.0 3.2 2.3 2.8 2.4 1.9 -1.4 2.3 -1.3 2.7
HDL Cholesterol 0.7 1.1 2.6 -0.9 -0.5 -1.1 -1.6 -0.8 1.4 -1.1 0.6 -1.0
LDL Cholesterol 0.5 0.8 1.4 1.2 1.2 1.1 0.4 0.9 -0.7 0.8 -0.3 1.1
Lupus 3.6 5.4 9.0 2.5 2.9 2.3 3.0 2.5 -1.2 2.5 -1.2 2.2
Neuroticism (2016) 1.3 1.8 2.8 1.6 1.7 1.5 1.0 1.4 -1.7 1.1 -0.2 1.4
Primary Biliary Cirrhosis 0.9 1.4 3.3 1.7 0.9 1.8 1.1 0.2 -0.1 1.2 -0.4 1.5
Rheumatoid Arthritis 0.7 1.0 2.1 -0.9 -1.4 -0.5 -0.7 -0.4 1.0 -1.5 1.3 -0.8
Schizophrenia (2014) 2.2 4.9 15.3 -1.3 -2.2 -1.0 -3.9 -1.9 2.3 -2.5 1.8 -1.6
Triglycerides 0.2 0.3 0.7 0.5 0.5 0.9 0.6 0.2 -0.4 0.4 0.0 0.7
Type 2 Diabetes (T2D) (2012) 0.8 0.9 1.5 -0.3 -1.0 -0.8 0.1 -1.0 1.2 -1.2 1.2 -1.0
Ulcerative Colitis 1.5 2.1 7.3 -0.7 -0.9 -0.3 -2.6 -1.3 2.7 -0.9 0.9 -0.4
Blood Eosinophil Count 0.7 5.7 9.7 2.9 2.8 2.9 2.1 2.0 -1.4 2.1 -1.3 3.1
Blood Platelet Count 0.5 6.3 9.3 2.8 2.9 2.9 2.6 1.7 -0.8 2.3 -2.6 3.0
Blood Red Count 0.1 1.0 6.6 -0.5 -0.0 -0.0 -1.4 -0.7 -0.2 0.0 -2.6 0.0
Blood White Count 0.0 0.2 0.5 0.6 0.3 0.4 0.0 -0.0 0.4 -0.1 0.7 0.3
Heel T-Score 0.3 2.1 16.1 -0.3 -0.3 -0.2 4.0 0.5 0.3 -0.1 1.5 -0.4
BMI 0.2 1.4 7.2 -1.2 -0.1 -1.3 2.7 -0.2 0.2 -1.0 0.8 -1.0
Height 0.3 5.3 13.0 2.7 1.7 3.1 0.0 1.8 -1.4 3.6 -0.5 3.0
Waist Hip Ratio (WHR) 3.2 14.6 25.6 5.0 3.4 5.1 3.0 2.5 -1.3 4.2 -3.6 4.7
Systolic Blood Pressure 0.6 3.0 10.6 -0.9 -1.5 -1.4 3.2 1.1 -1.9 -0.8 2.0 -1.4
Smoking Status 0.3 0.6 1.9 -0.6 -1.2 -0.5 -1.4 -0.5 0.5 -0.7 0.6 -0.6
Allergy or Eczema 0.3 0.8 1.3 0.9 1.0 1.2 -0.5 0.6 -1.1 0.3 -1.1 1.0
Cardiovascular Disease 2.4 8.0 27.2 1.5 1.0 1.1 5.2 3.7 -4.1 1.9 -2.0 1.6
Hypothyroidism (self reported) 0.1 0.3 1.2 0.1 -0.1 -0.5 0.2 -1.0 -0.1 -0.3 -1.1 -0.6
Respiratory disease 0.3 0.8 2.3 0.6 1.5 0.8 0.3 0.7 -0.7 1.3 -0.4 1.0
Type 2 Diabetes (T2D) (2018) 2.3 4.3 6.4 1.8 1.3 2.2 2.5 2.3 -2.4 2.1 -1.2 2.5
Lung FEV1/FVC ratio 0.5 2.6 22.0 0.1 0.8 0.1 4.7 -0.3 0.1 -0.4 0.3 0.1
Lung FVC 0.2 1.1 2.9 -1.3 0.1 -1.2 -0.6 -0.9 1.0 -0.7 1.7 -1.2
Neuroticism 0.5 1.3 2.9 1.6 1.3 1.1 0.6 0.6 -0.4 1.0 -1.7 0.9
Chronotype (morning person) 0.8 1.7 2.9 -1.2 -1.7 -1.7 0.5 -0.3 -1.1 -1.2 -1.7 -1.6
Hair Pigment 0.0 0.8 4.5 -1.1 -0.1 -0.5 -2.1 -0.9 -0.0 -0.3 0.1 -0.6
Tanning 0.3 3.9 8.5 -2.9 -2.2 -2.7 -1.4 -1.0 0.3 -2.4 0.7 -2.2
Hand grip strength (left) 0.1 0.3 1.3 -0.1 -0.8 -0.2 -0.8 -0.4 1.1 -0.1 0.4 0.0
Number of treatments/medications taken 0.5 0.9 2.4 0.2 0.4 0.2 1.1 1.6 -1.3 0.8 -1.1 0.6
Average weekly spirits intake 0.6 0.8 1.9 1.3 0.6 1.1 -0.3 -0.8 0.4 0.3 -1.4 0.9
Sensitivity / hurt feelings 1.1 1.8 2.9 1.6 1.5 1.4 1.6 1.2 -0.8 1.7 -0.0 1.4
Frequency of depressed mood in last 2 weeks 0.5 0.8 2.1 1.3 -0.1 1.0 -0.4 0.8 -0.8 0.4 -1.4 0.7
Hearing difficulty/problems: Yes 3.1 4.8 13.1 -0.9 -2.0 -1.4 -2.4 -2.9 3.6 -2.4 0.5 -1.7
Relative age of first facial hair 0.4 0.9 3.5 -0.7 -0.9 -0.4 -1.5 -0.4 0.8 0.1 1.9 -0.1
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 1.6 -0.9 -0.3 -1.3 0.3 -0.6 -0.7 -0.5 -0.9 -0.9
Ever used hormone-replacement therapy (HRT) 0.1 0.2 1.0 -0.5 -0.1 0.1 -1.0 -0.4 -0.1 0.4 -0.3 0.1
Ever had hysterectomy (womb removed) 1.0 1.1 1.9 -0.6 -1.1 -0.6 -1.1 -1.2 1.0 -1.3 1.4 -0.7
Systolic blood pressure, automated reading 0.7 2.0 4.5 -1.4 -1.4 -1.6 2.1 0.7 -1.0 -1.1 1.5 -1.5
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 1.1 0.7 0.4 0.8 0.7 0.9 -0.9 1.0 0.2 1.1
Angina 0.7 1.0 2.6 1.3 -0.1 0.7 1.5 1.2 -0.2 0.0 -1.6 0.5
Medication for hormone replacement therapy 0.5 0.5 1.9 0.2 0.4 0.9 -1.4 -0.4 1.1 0.4 -0.2 0.5
Vitamin and mineral supplements 0.4 0.5 2.8 0.9 -0.2 0.7 1.7 0.1 -0.1 0.4 0.1 0.6
Supplements: Zinc 2.3 2.5 7.1 -1.2 -0.2 -1.1 -2.7 -1.8 2.6 -1.3 0.1 -1.1
Medication: Co-codamol 1.9 2.3 5.0 1.2 0.8 1.4 2.2 0.9 -1.4 1.7 -2.0 1.3
Medication: Metformin 2.1 2.9 4.5 1.6 1.2 1.9 2.1 2.1 -1.7 1.5 -1.2 1.9
Diabetes (father) 0.7 0.9 1.6 0.7 0.7 1.2 -0.4 -0.5 1.3 1.1 0.9 1.2
Diabetes (mother) 1.2 1.6 3.0 0.9 1.7 1.3 1.4 0.2 -1.5 1.0 -1.4 1.2
Severe depression (siblings) 0.2 0.2 0.4 0.6 0.6 0.4 0.1 0.1 0.4 0.3 0.5 0.6
Pack years adult smoking proportion 1.2 1.9 5.1 0.9 -0.5 0.6 1.8 2.0 -2.3 1.4 -0.8 0.8
Impedance of leg (right) 0.3 1.5 6.9 1.1 0.5 0.9 1.3 0.9 -0.7 1.0 -2.6 0.6
Leg fat-free mass (left) 0.1 0.4 1.8 -0.1 -0.5 -0.3 0.5 -0.4 1.0 -0.0 1.4 -0.1
Trunk fat percentage 0.3 1.2 8.0 -0.3 -0.5 -0.9 2.8 0.9 -0.7 -0.3 -0.0 -0.8
Hand grip strength (right) 0.1 0.3 1.1 0.0 -0.5 -0.1 -0.8 -0.4 0.8 -0.0 1.0 0.1
Townsend deprivation index at recruitment 0.3 0.4 1.2 0.3 0.7 -0.1 -0.2 -1.1 0.3 0.6 -1.1 0.0
Current tobacco smoking 0.1 0.2 0.6 -0.3 -0.7 -0.6 0.2 -0.0 -0.8 -0.4 -0.0 -0.3
Average weekly fortified wine intake 0.6 0.7 1.5 0.5 1.2 0.8 0.8 0.9 -0.4 1.0 0.1 1.1
Maternal smoking around birth 0.4 0.5 1.2 0.5 0.9 0.0 1.1 0.5 -0.8 0.6 -1.1 0.2
Fed-up feelings 1.4 2.5 6.8 1.8 0.3 1.3 1.5 1.8 -0.7 1.7 -2.6 1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 1.6 -0.3 -0.9 -0.9 -1.0 -0.8 0.6 -1.3 -0.7 -1.2
Relative age voice broke 0.2 0.3 1.8 0.0 -0.7 -0.1 -0.4 0.1 -0.1 -0.2 1.4 0.0
Taking other prescription medications 1.4 2.2 3.8 1.3 1.8 1.2 1.3 1.3 -1.9 1.8 -0.7 1.6
Age when periods started (menarche) 0.2 0.4 1.5 0.9 0.7 0.5 -0.3 -0.3 -0.3 0.4 -1.2 0.1
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.5 -0.5 0.6 -0.1 -0.1 -0.7 -0.6 0.0 0.3 -0.0
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.0 8.2 -0.8 -1.6 -1.3 2.9 1.3 -1.0 -0.2 1.1 -0.9
Tinnitus: Yes, but not now, but have in the past 0.7 0.8 2.0 0.6 0.3 1.1 0.4 1.0 -0.6 1.4 -0.7 1.1
Qualifications: CSEs or equivalent 1.0 1.3 4.7 1.2 0.7 1.4 0.5 0.4 -0.5 0.6 -2.2 1.6
Serious illness, injury or assault to yourself 0.2 0.3 1.0 -0.3 -1.0 -0.3 -0.4 -0.6 -0.4 -0.3 -0.4 -0.1
High blood pressure 1.1 3.1 13.9 0.6 -0.0 -0.2 3.7 2.6 -2.4 0.7 -0.4 0.1
Hayfever, allergic rhinitis or eczema 0.4 0.9 2.5 1.0 0.8 1.6 -0.5 0.2 -0.7 0.4 -1.2 1.3
Multivitamins +/- minerals 1.2 1.5 6.8 -1.3 -0.7 -0.8 -2.6 -0.5 1.3 -1.1 0.4 -0.8
Stomach or abdominal pain in last month 1.2 1.5 3.3 1.8 1.4 1.7 0.3 0.4 0.4 1.6 -0.5 1.6
Supplements: Glucosamine 2.8 3.7 6.6 -2.0 -1.4 -2.1 -2.2 -1.5 1.8 -2.6 0.6 -2.2
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 4.6 0.4 1.7 0.7 2.1 0.2 -1.5 0.7 -0.7 0.6
Medication: Atenolol 1.6 2.0 9.6 1.2 0.3 0.9 3.1 1.8 -1.2 0.6 -0.3 0.7
Medication: Levothyroxine sodium 0.4 0.7 1.6 1.2 0.2 0.8 -0.6 -1.3 0.8 -0.1 -1.1 0.3
Sitting height 0.3 2.2 5.7 2.0 0.9 2.2 -0.4 0.7 -0.2 2.4 0.1 1.9
Chronic bronchitis/emphysema (father) 0.0 0.0 0.1 0.1 -0.1 -0.2 -0.1 0.4 -0.2 -0.1 -0.2 -0.3
High blood pressure (mother) 2.9 4.1 17.7 1.8 0.8 1.2 4.2 2.2 -2.4 1.0 -1.0 1.1
Body mass index (BMI) 0.3 1.4 6.2 -1.0 -0.6 -1.4 2.5 -0.1 -0.2 -1.2 0.6 -1.1
Impedance of leg (left) 0.4 1.8 6.9 1.4 0.7 1.1 1.3 1.0 -1.0 1.2 -2.6 0.8
Leg predicted mass (left) 0.1 0.4 1.6 -0.1 -0.5 -0.2 0.6 -0.4 0.9 0.0 1.3 -0.0
Trunk fat mass 0.2 1.0 8.0 -0.0 -0.4 -0.5 2.8 0.8 -0.5 -0.1 0.0 -0.4
Waist circumference 0.6 2.0 10.6 1.4 1.1 1.1 3.2 1.0 -0.4 0.9 -0.2 1.1
Number of incorrect matches in round 0.3 0.6 1.6 1.1 1.2 0.7 -0.0 0.0 0.8 0.7 0.4 0.7
Past tobacco smoking 0.2 0.4 1.3 -0.4 0.9 -0.5 1.0 0.7 -1.1 0.1 -0.2 -0.1
Alcohol usually taken with meals 0.6 0.9 5.5 0.0 0.7 0.3 -0.1 -0.2 1.4 0.4 2.4 0.1
Nervous feelings 5.2 9.6 14.6 3.5 3.3 3.6 2.9 3.0 -2.5 3.8 -0.5 3.6
Frequency of tenseness / restlessness in last 2 weeks 1.2 1.9 8.3 1.9 1.3 1.4 0.1 -0.1 -0.4 0.9 -2.9 1.0
Hearing difficulty/problems with background noise 4.3 6.8 17.8 -1.8 -1.9 -1.6 -4.2 -3.8 3.2 -2.5 0.3 -2.0
Hair/balding pattern: Pattern 2 0.8 1.0 2.7 -1.6 -0.0 -1.6 0.1 -1.4 -0.1 -0.5 -0.5 -1.3
Had menopause 0.6 0.8 3.6 -1.0 0.2 -0.5 -1.9 -0.2 0.2 0.1 1.3 -0.3
Had other major operations 0.4 0.4 2.8 -0.4 -0.4 0.1 -1.7 -0.7 0.5 -0.1 -0.2 0.3
Forced vital capacity (FVC) 0.2 0.8 1.5 0.2 1.0 0.6 -1.2 -0.7 1.2 0.8 1.1 0.6
Heel bone mineral density (BMD) T-score, automated (right) 1.6 3.6 7.5 -2.1 -2.7 -2.7 1.5 0.1 0.6 -1.6 1.5 -2.4
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 3.5 -0.6 -1.4 -0.8 -1.2 -0.5 0.5 -1.0 1.9 -0.5
Qualifications: None of the above 1.3 2.9 6.9 0.8 1.9 1.0 2.3 1.0 -1.6 1.7 -2.6 1.4
Financial difficulties in last 2 years 0.5 0.7 1.8 -1.4 -0.8 -0.8 -0.4 -1.2 0.7 -1.0 -0.1 -0.4
Mouth/teeth dental problems 0.2 0.2 1.0 0.3 1.0 0.3 0.4 0.6 -0.1 0.6 0.1 0.2
Heart attack 0.6 0.8 2.3 0.8 -0.8 0.5 1.1 1.5 -0.7 0.4 -1.2 0.6
Allergy 1.0 2.4 5.2 -1.8 -1.6 -2.3 -0.1 -0.7 0.8 -1.3 1.7 -2.2
Pain all over the body in last month 1.4 1.5 3.8 -1.1 -1.9 -1.5 -0.0 -0.1 0.3 -1.2 -1.6 -1.6
Diabetes (self-reported) 3.3 5.1 9.2 2.1 1.4 2.2 3.0 2.5 -2.2 2.0 -1.8 2.5
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 2.2 1.0 1.5 1.1 -0.2 1.4 -1.4 0.9 0.4 0.8
Medication: Ramipril 0.5 0.6 2.9 0.6 -0.7 -0.0 1.7 0.9 -0.8 0.4 -0.3 -0.1
Medication: Simvastatin 1.1 1.6 6.2 0.2 1.3 0.4 2.5 1.2 -1.8 0.3 -0.5 0.8
Fluid intelligence score 0.7 1.5 4.4 -1.4 -1.3 -1.3 0.1 -0.5 -0.6 -1.3 2.1 -1.3
Illnesses of siblings 0.5 0.7 3.8 -0.7 -0.0 -0.7 -2.0 -0.6 0.4 -0.5 0.2 -1.0
Neuroticism score 0.9 1.9 4.7 2.2 1.3 1.4 1.0 0.8 -0.5 1.3 -1.8 1.3
Weight 0.1 0.6 4.5 -0.0 -0.3 -0.3 2.1 0.2 0.0 0.1 0.6 -0.0
Impedance of arm (right) 0.1 0.3 0.7 0.7 -0.0 0.7 -0.2 0.8 0.2 0.8 -0.8 0.3
Arm fat percentage (right) 0.3 1.1 6.9 -0.5 -0.5 -0.9 2.6 0.3 0.0 -0.8 0.3 -0.8
Trunk fat-free mass 0.1 0.4 0.9 0.6 0.1 0.6 0.2 -0.6 0.9 0.7 0.8 0.8
Hip circumference 0.2 0.9 4.0 -0.6 -0.5 -1.0 2.0 -0.1 0.5 -0.3 1.3 -0.7
Time employed in main current job 1.1 1.3 4.6 0.2 1.5 0.4 0.8 1.5 -2.1 0.8 -0.9 0.7
Alcohol intake versus 10 years previously 1.4 2.0 4.6 1.5 1.3 2.1 0.1 0.9 -1.3 1.4 -1.1 2.0
Father’s age at death 0.3 0.5 1.7 -0.6 0.5 -0.0 -1.0 -0.1 -1.3 0.1 0.9 0.2
Worrier / anxious feelings 1.3 2.4 4.0 1.7 1.0 1.6 1.5 1.1 -2.0 2.0 -0.9 1.7
Frequency of tiredness / lethargy in last 2 weeks 1.3 2.1 6.0 2.4 0.7 1.6 0.6 1.4 -0.7 1.2 -1.9 1.6
Falls in the last year 0.4 0.5 2.1 0.5 -0.7 -0.3 0.4 1.5 -0.7 0.6 -0.8 0.1
Hair/balding pattern: Pattern 3 1.7 2.6 3.9 1.6 2.0 1.6 1.8 1.1 -1.1 1.9 -1.7 1.5
Number of live births 0.7 1.0 4.1 -0.3 -0.6 -0.4 2.0 1.6 -0.4 -0.4 -1.2 0.1
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 2.3 -0.7 1.3 -0.1 -0.3 -1.5 1.5 0.2 0.9 -0.1
Pulse rate 0.9 1.5 4.7 -1.1 -2.2 -1.3 -0.6 -0.2 0.1 -1.2 -1.4 -1.3
Happiness 0.9 1.1 2.7 1.1 0.6 1.2 0.5 1.6 -1.0 0.8 0.6 1.4
Noisy workplace 1.2 1.4 6.6 -0.8 0.5 -0.8 -1.6 -2.6 1.1 -0.3 -0.7 -0.5
Qualifications: A levels/AS levels or equivalent 0.4 0.9 2.8 -0.4 -0.9 -0.2 -1.0 0.2 1.6 -0.6 1.7 -0.4
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 2.4 1.3 -0.6 0.7 0.4 1.5 -0.6 0.2 -0.4 1.0
Mouth/teeth dental problems: Dentures 0.2 0.4 1.7 -0.4 -1.3 -0.3 -0.3 -0.9 0.6 0.2 -0.4 -0.1
Asthma 1.2 2.3 3.0 1.6 1.7 1.4 1.6 1.7 -1.1 1.6 -1.0 1.6
Medication: Ibuprofen (e.g. Nurofen) 2.4 3.0 4.5 -1.4 -2.1 -1.7 -2.1 -1.8 1.9 -1.9 0.5 -1.8
Medication: Cholesterol lowering 1.4 2.1 8.9 0.6 0.5 0.4 3.0 1.7 -2.3 0.6 -0.7 0.8
Depression (self-reported) 0.6 0.7 1.6 0.7 1.0 1.0 0.6 0.5 -0.5 1.2 -0.1 1.3
Medication: Lansoprazole 1.3 1.5 3.8 -1.6 -0.6 -1.9 -0.4 -1.0 0.5 -1.2 -0.7 -1.9
Prospective memory result 0.5 0.7 5.0 -0.0 0.3 0.3 -0.0 -0.6 0.5 0.4 -2.2 0.2
Lung cancer (father) 2.0 2.3 3.8 1.3 1.9 1.2 0.8 0.8 -1.8 1.6 -1.9 1.8
Illnesses of mother 1.2 1.4 3.3 -1.3 -1.2 -0.7 -1.8 -1.4 1.7 -0.4 0.8 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.8 2.9 0.3 1.7 0.8 0.5 -1.1 0.8 1.0 0.3 0.6
Pulse wave Arterial Stiffness index 4.2 4.9 9.7 0.9 2.5 1.0 2.7 2.3 -3.1 2.4 -2.4 1.6
Impedance of arm (left) 0.1 0.5 1.1 0.8 0.2 0.7 -0.1 1.1 0.1 1.0 -1.1 0.5
Arm fat mass (right) 0.2 0.9 5.7 -0.4 -0.6 -0.8 2.4 0.2 0.2 -0.6 0.4 -0.6
Trunk predicted mass 0.1 0.4 1.0 0.5 0.1 0.6 0.1 -0.6 1.0 0.6 0.8 0.7
Standing height 0.2 2.1 5.2 2.0 0.5 2.0 -0.9 0.4 0.7 2.3 -0.0 1.9
Length of working week for main job 1.1 1.2 5.5 0.1 -0.3 0.1 -0.5 -2.0 2.3 -0.3 0.7 -0.2
Exposure to tobacco smoke at home 1.2 1.3 2.9 1.2 0.4 1.0 1.3 1.7 -1.1 1.5 -0.9 0.8
Breastfed as a baby 0.5 0.7 2.2 -1.5 -0.8 -1.1 0.0 -0.8 -0.2 -0.6 -0.6 -0.7
Tense / ‘highly strung’ 0.9 1.6 4.9 0.9 0.6 1.1 1.1 0.6 -2.2 1.6 -0.8 1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 2.0 1.4 -0.1 0.6 0.3 0.4 0.3 0.2 -0.7 0.3
Hair/balding pattern: Pattern 4 0.2 0.6 2.6 0.1 -1.2 -0.3 0.1 0.9 -0.1 -0.4 1.6 -0.2
Birth weight of first child 0.3 0.6 3.0 -0.3 -0.9 0.0 -1.7 0.0 -0.3 -0.1 1.0 0.2
Peak expiratory flow (PEF) 0.3 0.6 2.6 -0.5 1.6 -0.0 1.4 -0.5 0.1 0.4 0.4 -0.1
Pulse wave reflection index 1.1 1.3 4.7 0.0 1.4 -0.2 1.7 0.9 -2.2 1.1 -0.5 0.3
Ever highly irritable/argumentative for 2 days 0.9 1.1 3.1 -1.1 -1.8 -0.7 -1.7 0.3 0.7 -0.9 -0.6 -0.4
Loud music exposure frequency 1.1 1.3 5.5 -0.7 -0.6 -0.2 -1.8 -2.3 0.9 -0.6 -0.6 -0.3
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.8 0.5 -0.5 0.1 -0.0 0.5 0.7 -0.7 0.9 -0.3
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.3 0.2 0.5 0.3 0.6 0.2 -0.5 -0.2 -0.1 0.1
Blood clot in the leg (DVT) 0.2 0.3 0.5 -0.3 0.2 -0.5 -0.6 -0.6 -0.2 -0.7 0.6 -0.4
Medication: Paracetamol 0.7 1.1 4.4 -0.4 -1.1 -0.8 -0.8 -0.2 0.9 -1.1 -2.1 -0.8
Headache pain in last month 0.7 1.2 2.6 1.4 1.3 1.5 -0.4 0.0 -0.2 0.7 -1.6 1.3
Medication for cholesterol, blood pressure or diabetes 1.2 1.9 9.9 -0.6 -0.5 -0.3 -3.1 -1.7 1.8 -0.7 -0.1 -0.6
Glaucoma (self-reported) 0.8 1.0 2.2 -0.7 -0.8 -1.2 -1.2 0.7 0.3 -1.1 1.5 -0.9
Gout (self-reported) 1.1 1.4 4.2 0.6 2.0 0.6 1.5 0.9 -1.4 1.3 -0.5 1.0
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 2.2 0.4 0.1 0.0 -0.8 -1.5 1.0 -0.7 -0.5 -0.4
Medication: Amlodipine 0.9 1.3 4.5 -0.0 -0.2 0.5 1.3 1.6 -1.2 0.7 2.1 0.6
Medication: Ventolin 100micrograms inhaler 0.7 0.9 2.1 1.0 1.4 0.4 0.9 1.0 0.1 0.8 -1.3 0.6
Birth weight 0.3 0.6 2.2 -0.8 0.1 -0.0 -1.4 -1.5 0.4 0.1 -0.3 -0.1
Chronic bronchitis/emphysema (mother) 0.9 1.1 2.3 -1.0 -0.1 -1.5 -1.1 -0.5 0.1 -1.5 -0.8 -1.5
High blood pressure (siblings) 0.5 0.8 2.6 0.7 -0.8 0.5 1.6 1.1 -1.1 0.3 0.1 0.8
Forced vital capacity (FVC), Best measure 0.3 1.1 2.7 0.8 1.6 1.2 -0.3 -0.5 0.7 1.5 0.5 1.1
Body fat percentage 0.4 1.5 10.8 -0.3 -0.3 -0.8 3.3 0.9 -0.7 -0.3 -0.4 -0.7
Leg fat percentage (right) 0.7 2.5 18.5 -0.4 -0.0 -1.0 4.3 0.7 -1.0 -0.4 -0.7 -0.7
Arm fat-free mass (right) 0.0 0.1 0.4 0.2 -0.2 0.1 0.6 -0.3 0.3 0.2 0.6 0.2
Exposure to tobacco smoke outside home 1.6 2.1 7.3 1.6 1.8 1.8 -0.3 -1.0 0.4 0.7 -2.7 1.1
Comparative body size at age 10 0.4 1.0 5.7 -0.2 -0.1 -0.6 2.4 0.8 -0.6 -1.4 0.3 -0.2
Number of full brothers 0.5 0.7 1.3 -0.8 -0.4 -0.9 1.0 -0.7 -0.3 -1.1 -0.8 -1.0
Worry too long after embarrassment 0.2 0.3 0.5 0.7 0.7 0.3 0.3 0.7 0.5 0.7 -0.3 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.1 1.0 0.3 0.8 -0.4 -0.0 -0.2 0.4 -1.1 0.9
Wheeze or whistling in the chest in last year 2.4 4.2 5.7 1.9 1.4 1.7 2.0 2.2 -2.4 2.3 -2.2 2.2
Number of children fathered 0.0 0.0 0.2 0.2 0.5 -0.0 0.2 -0.2 -0.0 0.3 -0.1 0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 1.7 -0.6 -0.1 0.0 -1.2 -0.3 0.1 0.1 1.3 0.2
Age at first live birth 1.9 3.4 8.5 -1.6 -1.3 -1.2 -2.5 -1.6 1.1 -1.9 2.9 -1.7
Pulse wave peak to peak time 3.5 4.2 9.4 -0.5 -2.1 -0.6 -2.7 -2.1 3.1 -2.0 2.4 -1.2
Health satisfaction 0.3 0.4 1.9 1.4 0.2 0.7 0.2 0.3 -0.4 0.4 -0.5 0.8
Shortness of breath walking on level ground 0.4 0.5 2.8 -0.1 -0.6 -0.4 0.1 0.0 0.9 -0.4 -1.7 -0.6
Qualifications: College or University degree 1.9 6.1 12.5 -2.2 -2.0 -1.3 -3.2 -2.1 3.4 -2.1 3.5 -1.4
Eye problems/disorders: None of the above 2.6 3.0 5.1 1.7 1.9 2.1 2.0 -0.2 -1.0 2.3 -1.3 2.1
Mouth/teeth dental problems: Loose teeth 0.3 0.3 0.9 0.3 -0.8 -0.2 -0.7 -0.1 0.5 -0.6 -0.9 -0.4
Emphysema/chronic bronchitis 0.2 0.3 1.3 0.3 -0.7 0.5 0.0 -0.4 -0.0 0.2 -1.1 0.2
Medication for pain relief, constipation, heartburn 0.6 1.0 8.1 -0.7 0.2 0.1 -0.3 -0.2 0.2 0.2 2.9 -0.0
Neck or shoulder pain in last month 1.3 1.9 5.1 1.6 -0.1 1.8 0.8 0.0 -1.0 0.9 -2.3 1.9
Medication: Blood pressure 1.3 2.4 12.9 0.9 0.7 0.2 3.6 1.9 -1.5 0.9 0.5 0.6
Angina (self-reported) 0.8 1.1 3.0 1.3 0.3 0.8 1.6 1.1 -0.3 0.2 -1.7 0.7
Migraine (self-reported) 1.2 1.4 3.1 -1.6 -1.0 -1.3 -1.2 -0.3 0.4 -1.2 1.8 -1.2
Medication: Ibuprofen 2.2 2.6 4.9 -1.5 -2.2 -1.8 -1.8 -1.2 1.4 -1.8 0.6 -1.6
Medication: Allopurinol 0.1 0.1 0.3 0.4 0.4 -0.1 0.6 0.5 -0.2 0.3 -0.1 0.1
Medication: Omeprazole 2.9 3.4 5.7 2.1 1.3 2.2 2.0 1.3 -2.4 1.6 -1.3 2.0
Medication: Seretide 50 evohaler 1.0 1.1 2.6 1.2 0.8 1.1 1.1 1.6 -0.4 0.6 -1.3 0.8
Mean time to correctly identify matches 0.2 0.4 2.1 0.0 0.1 0.1 -0.7 -1.4 0.3 -0.2 -1.1 -0.1
Heart disease (mother) 0.7 0.9 3.1 -0.6 -0.7 -1.1 -0.7 -0.7 1.8 -1.2 0.1 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 1.0 0.4 1.0 0.4 1.0 0.1 -0.5 0.1 -1.0 0.5
Whole body fat mass 0.3 1.1 8.8 -0.1 -0.3 -0.6 3.0 0.7 -0.4 -0.2 -0.1 -0.5
Leg fat mass (right) 0.4 1.4 9.4 -0.6 -0.5 -1.1 3.1 0.2 -0.2 -0.7 0.1 -0.9
Arm predicted mass (right) 0.0 0.1 0.3 0.2 -0.2 0.0 0.5 -0.4 0.4 0.2 0.5 0.2
Pulse rate, automated reading 0.6 2.0 11.4 0.5 -1.2 0.1 1.3 1.3 -1.1 0.3 -3.4 -0.0
Alcohol intake frequency. 0.6 1.5 2.9 0.7 0.7 0.9 1.6 1.5 -1.3 0.9 -1.7 1.1
Comparative height size at age 10 0.3 1.4 3.3 1.4 0.6 1.7 0.1 0.1 0.9 1.8 -0.6 1.8
Number of full sisters 1.4 1.7 3.7 -1.6 -1.4 -1.9 -0.4 0.2 0.6 -1.5 -0.6 -1.9
Suffer from ‘nerves’ 1.0 1.6 3.2 1.2 1.4 1.2 1.1 0.3 -1.4 1.8 -1.3 1.3
Overall health rating 0.5 1.0 4.5 0.6 0.4 0.0 2.1 0.2 -1.2 0.3 -1.4 0.2
Chest pain or discomfort 0.5 0.8 3.8 0.3 0.1 -0.3 1.7 0.2 -0.1 -0.3 -1.9 -0.2
Had major operations 0.3 0.3 1.8 -0.2 0.1 -0.0 -0.8 -1.3 0.3 -0.4 -0.2 -0.1
Age at last live birth 1.1 1.6 6.1 -1.0 -0.8 -1.0 -0.8 -1.2 0.6 -1.4 2.5 -1.2
Family relationship satisfaction 0.2 0.3 1.2 0.1 -1.1 0.1 -0.9 0.2 0.2 -0.4 0.0 0.2
Leg pain on walking 0.6 0.7 3.9 -0.1 0.2 -1.0 0.5 0.3 -0.8 -0.3 -2.0 -0.7
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 2.1 1.2 -1.0 0.7 0.0 -0.4 -0.0 0.2 -1.5 0.5
Commuting to job workplace: Car/motor vehicle 0.9 1.0 2.6 0.9 1.6 1.2 1.1 0.9 -0.4 1.0 -0.5 1.0
Illness, injury, bereavement, stress in last 2 years 1.3 1.5 3.4 -1.4 -0.3 -1.4 -0.9 -1.3 1.0 -1.4 1.0 -1.8
Medication: Aspirin 0.7 1.0 5.0 0.8 -0.3 0.4 0.8 0.9 -0.8 0.6 -2.2 0.7
Supplements: Vitamin C 0.3 0.4 1.5 0.0 1.2 -0.4 -0.7 -1.0 0.0 0.1 -0.2 -0.4
Knee pain experienced in last month 1.2 1.8 3.5 -1.5 -1.9 -1.7 -1.0 -0.8 0.5 -1.6 1.0 -1.6
Hypertension (Self-reported) 1.1 3.0 14.2 0.8 -0.0 -0.2 3.8 2.6 -2.3 0.7 -0.3 -0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.5 1.7 3.1 -1.1 -0.2 -1.2 -1.8 -1.6 1.5 -1.7 -0.3 -1.5
Illnesses of father: Heart disease 0.3 0.4 1.1 0.6 -1.1 0.9 0.8 0.1 -0.4 -0.6 -0.3 0.4
Illnesses of siblings: Diabetes 0.2 0.3 0.9 -1.0 0.2 -0.2 0.7 -0.5 -0.2 0.5 -0.7 0.2
Smoking status: Previous 0.4 0.6 1.9 -0.1 -0.9 0.0 -1.3 -0.5 1.4 -0.3 0.7 -0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.5 2.9 1.7 0.9 1.7 0.4 1.2 -0.4 1.1 -0.9 1.7
Whole body fat-free mass 0.1 0.3 1.0 0.3 -0.1 0.2 0.3 -0.6 1.0 0.4 1.0 0.4
Leg fat-free mass (right) 0.1 0.4 2.1 0.0 -0.3 -0.1 0.2 -0.5 0.9 0.1 1.4 0.0
Arm fat percentage (left) 0.3 1.2 7.1 -0.7 -0.6 -1.1 2.7 0.4 -0.0 -0.9 0.2 -0.9
Average weekly red wine intake 1.0 1.5 2.6 -1.2 -0.4 -1.3 -1.3 -1.3 1.4 -1.0 1.6 -1.2
Handedness (chirality/laterality): Left-handed 0.2 0.3 0.8 -0.9 -0.3 -0.5 -0.1 -0.0 -0.7 -0.6 0.6 -0.5
Mood swings 0.7 1.3 3.1 1.8 0.8 1.3 0.3 0.7 -0.4 1.4 -1.7 1.1
Loneliness, isolation 0.6 0.9 2.5 1.1 1.1 0.9 0.6 0.6 -0.7 0.6 -1.6 0.7
Long-standing illness, disability or infirmity 0.4 0.6 1.1 0.6 0.0 0.6 1.1 0.6 -0.9 0.8 -0.9 0.9
Ever had bowel cancer screening 1.1 1.2 2.6 1.6 0.7 1.6 1.0 0.5 -0.4 1.2 -0.5 1.6
Diabetes diagnosed by doctor 3.3 5.3 9.4 2.0 1.6 2.3 3.1 2.5 -2.5 2.1 -1.7 2.6
Ever had stillbirth, spontaneous miscarriage or termination 1.6 1.7 4.5 1.7 1.3 1.3 1.2 0.2 0.2 1.3 -2.1 1.2
Friendships satisfaction 0.4 0.5 1.5 0.4 -0.2 0.6 -0.9 1.2 -1.0 -0.2 0.3 0.6
Qualifications: nursing, teaching 0.3 0.5 2.5 0.1 -0.6 0.1 -1.1 -0.2 1.6 -0.4 0.4 -0.0
Commuting to job workplace: Walk 0.3 0.3 1.3 0.6 -0.5 0.1 -0.4 -0.6 -0.2 0.1 -1.1 0.3
Eye problems/disorders: Cataract 0.5 0.6 1.9 -0.3 -0.4 -0.4 -0.7 1.4 0.2 -0.7 1.4 -0.6
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 1.9 0.9 -0.2 0.6 -0.5 -0.2 1.4 -0.7 -0.0 0.6
Medication for cholesterol 0.3 0.4 1.3 -0.5 0.1 -0.4 -0.9 -0.7 0.7 -0.2 1.1 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.9 0.7 -0.8 0.1 0.6 -0.1 0.0 -0.2 -1.4 -0.0
Back pain experienced in last month 1.5 2.2 4.9 1.2 2.1 1.1 1.1 0.6 -0.6 2.2 -1.5 1.8
Mineral and other dietary supplements 3.2 4.2 9.8 2.1 1.3 2.2 3.1 1.6 -1.7 2.4 -0.9 2.4
Breast cancer (self-reported) 0.5 0.6 2.1 0.6 1.4 0.6 0.2 0.5 -0.5 1.2 0.2 0.4
Asthma (self-reported) 1.4 2.8 3.8 1.8 1.8 1.5 1.9 1.9 -1.1 1.8 -1.1 1.8
Osteoporosis (self-reported) 1.3 1.6 2.7 1.0 1.4 1.0 1.0 1.4 -1.6 1.2 -1.0 1.3
Osteoarthritis (self-reported) 1.0 1.3 2.2 -1.5 -1.2 -1.3 -0.9 -1.1 -0.0 -1.3 -1.0 -1.2
Medication: Aspirin 0.6 0.8 4.0 0.4 -0.5 -0.0 0.9 0.9 -1.0 0.4 -2.0 0.4
Medication: Gliclazide 1.2 1.3 2.6 1.4 0.8 1.6 1.6 1.0 -0.9 0.5 -0.3 1.4
Illnesses of father: None of the above (group 1) 0.3 0.3 0.9 0.5 0.9 0.3 0.5 0.5 -0.2 0.9 -0.1 0.4
Smoking status: Current 0.1 0.2 0.6 -0.2 -0.8 -0.5 0.0 -0.2 -0.7 -0.4 -0.1 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 2.4 0.4 1.5 0.9 0.3 -0.8 1.2 0.3 0.2 0.9
Whole body water mass 0.1 0.3 1.2 0.3 -0.1 0.3 0.3 -0.5 0.9 0.4 1.1 0.5
Leg predicted mass (right) 0.1 0.4 2.3 -0.0 -0.4 -0.2 0.2 -0.6 0.9 0.0 1.5 -0.0
Arm fat mass (left) 0.2 1.0 5.5 -0.7 -0.7 -1.0 2.4 0.1 0.2 -0.8 0.6 -0.8
Number of self-reported non-cancer illnesses 0.9 1.6 4.6 0.9 0.8 0.8 2.1 1.4 -1.7 1.2 -0.2 1.1
Average weekly champagne plus white wine intake 0.1 0.1 0.4 0.2 0.6 0.2 0.1 0.2 0.6 0.3 -0.4 0.3
Miserableness 1.9 3.3 7.1 2.7 1.7 1.9 1.5 0.9 -1.3 1.5 -2.5 1.7
Guilty feelings 0.1 0.1 0.2 0.2 0.2 -0.4 -0.5 -0.1 -0.3 -0.4 -0.3 -0.2
Wears glasses or contact lenses 0.7 0.9 2.1 -0.8 -1.3 -0.7 -1.5 -1.0 0.6 -0.7 -0.1 -0.9
Ever taken oral contraceptive pill 0.9 1.0 2.4 -1.4 -1.2 -1.5 0.5 -0.0 0.1 -1.1 -0.3 -1.2
Hearing aid user 0.6 0.7 1.6 -0.1 -1.2 -0.8 0.9 0.2 0.4 -0.8 -1.3 -0.7
Mother’s age at death 0.8 1.0 2.0 1.0 1.4 1.3 0.0 0.9 -0.9 0.9 0.8 1.2
Financial situation satisfaction 0.3 0.4 1.1 1.0 0.4 0.8 -1.1 -0.1 0.1 0.3 -0.4 0.5
Tinnitus: Yes, now most or all of the time 3.1 3.6 5.7 -2.1 -1.6 -2.4 -1.9 -1.6 2.1 -2.1 0.1 -2.1
Commuting to job workplace: Public transport 0.5 0.6 2.5 -0.6 -1.6 -1.1 0.2 -0.3 0.7 -0.6 0.4 -0.7
Eye problems/disorders: Glaucoma 1.1 1.3 2.8 -1.1 -1.3 -1.7 -1.5 0.2 0.8 -1.1 0.7 -1.2
Medication: Blood pressure 0.8 1.5 5.0 0.4 0.1 0.1 2.2 1.5 -2.1 0.1 -1.1 -0.0
Pain type(s) experienced in last month: Hip pain 1.7 2.1 3.1 1.5 1.7 1.3 1.3 0.8 -1.2 1.8 -1.5 1.7
Supplements: Fish oil (including cod liver oil) 0.8 1.0 3.0 -1.0 -0.9 -1.1 -1.7 0.1 0.6 -0.9 0.5 -1.3
High cholesterol (Self-reported) 1.3 2.2 6.9 0.7 1.3 0.6 2.6 1.1 -2.2 1.0 -1.7 1.0
Medication: Bendroflumethiazide 0.7 1.1 4.2 0.2 0.0 -0.0 2.1 1.3 -1.8 0.4 -0.5 0.2
Medication: Paracetamol 0.6 1.0 2.4 -0.3 -1.4 -0.7 -0.9 -0.1 1.0 -1.2 -1.6 -0.8
Medication: Lisinopril 3.0 3.9 7.6 2.8 2.5 2.3 2.1 1.5 -0.7 2.0 -0.8 1.9
Medication: Atorvastatin 0.2 0.3 1.1 0.6 -1.0 0.3 0.4 -0.5 -0.5 -0.3 0.1 -0.1
Illnesses of father: High blood pressure 0.9 1.1 1.8 -1.1 -0.8 -1.2 -0.1 -1.4 0.9 -1.3 -0.5 -1.3
Alcohol drinker status: Never 1.3 1.6 2.7 -1.4 -1.3 -1.6 -1.0 -1.3 0.7 -1.4 0.7 -1.6
Ever smoked 0.2 0.3 0.9 0.9 -0.1 0.8 -0.0 -0.0 0.6 0.5 0.2 0.6
Basal metabolic rate 0.0 0.3 0.8 0.2 -0.3 0.1 0.8 -0.4 0.7 0.3 0.9 0.3
Leg fat percentage (left) 0.6 2.3 17.6 -0.3 0.1 -0.9 4.2 0.7 -1.1 -0.4 -0.6 -0.7
Arm fat-free mass (left) 0.0 0.2 0.6 -0.1 -0.3 -0.2 0.6 -0.6 0.6 -0.0 0.8 0.0
Number of operations (self-reported) 1.0 1.4 5.2 -0.9 -0.3 -0.6 -2.2 -2.3 0.4 -1.0 -0.2 -0.6
Average weekly beer plus cider intake 0.6 0.8 2.6 -0.9 -1.1 -0.8 -1.6 -1.1 0.5 -0.6 -0.0 -0.5
Irritability 1.2 2.1 4.1 2.0 0.7 1.3 1.6 1.2 -1.3 1.3 -1.9 1.2
Risk taking 2.2 3.2 11.0 -1.9 -0.6 -1.7 -2.2 -3.3 1.6 -0.8 0.8 -1.5
Ever had prostate specific antigen (PSA) test 3.0 3.4 6.5 1.9 2.5 2.1 1.4 1.0 -1.4 1.9 -1.2 2.5
Fractured/broken bones in last 5 years 0.2 0.2 1.0 0.1 0.4 -0.5 0.1 -0.4 -0.1 -0.1 -1.0 -0.5
Age started oral contraceptive pill 1.4 1.8 5.0 -1.6 -0.4 -1.0 -1.2 -0.8 2.0 -0.9 2.2 -0.9
Diastolic blood pressure, automated reading 1.2 3.7 7.2 -2.2 -2.5 -2.7 -0.3 -1.5 0.6 -2.5 -0.4 -2.4
Ever depressed for a whole week 0.5 0.7 2.5 0.8 0.1 1.0 -0.9 0.2 0.7 0.2 1.6 0.7
Unable to work because of sickness or disability 0.8 1.1 6.2 -0.0 -1.0 -0.6 0.5 0.5 -1.0 -0.4 -2.5 -0.7
Commuting to job workplace: Cycle 3.1 3.7 6.6 -1.6 -2.5 -1.7 -1.9 -1.4 1.6 -2.6 1.8 -1.9
Myopia 0.8 1.2 5.3 -1.1 -0.9 0.2 -2.3 -1.2 1.1 -0.1 0.9 -0.1
Vascular/heart problems diagnosed by doctor 1.4 3.8 16.8 -1.1 0.2 -0.3 -4.1 -2.8 2.5 -0.9 1.1 -0.5
Cholesterol lowering medication 0.5 0.7 3.4 0.7 0.5 0.5 1.8 0.4 -0.7 0.1 -0.9 0.6
Medication: Omeprazole (e.g. Zanprol) 1.1 1.3 4.5 1.1 -0.1 1.1 1.2 0.7 -2.1 0.5 -1.3 0.9
Pain experienced in last month 2.4 3.9 6.5 -2.4 -2.1 -2.4 -1.3 -0.8 1.0 -2.1 2.4 -2.5
Supplements: Calcium 1.2 1.3 3.2 -1.3 -0.2 -1.0 -1.8 -1.5 0.3 -1.1 -1.2 -1.1
Basal cell carcinoma (self-reported) 0.6 0.7 2.0 0.6 1.0 1.4 0.0 0.0 -0.3 1.3 0.6 1.2
Heart attack/myocardial infarction (self-reported) 0.9 1.2 2.9 1.1 -0.8 0.7 1.3 1.7 -0.9 0.5 -1.4 0.8
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.7 -0.2 0.1 -0.4 -0.6 -0.8 0.0 -0.7 0.6 -0.4
Heart disease (siblings) 0.6 0.7 2.9 0.2 1.1 0.0 1.7 -0.1 -0.0 0.2 -1.4 0.1
Alcohol drinker status: Previous 0.4 0.5 1.0 -0.7 -1.0 -0.5 0.4 1.0 -0.7 -0.6 -0.6 -0.4
Pack years of smoking 1.1 1.5 4.8 0.6 -0.6 0.4 1.6 1.8 -2.2 1.1 -0.8 0.7
Impedance of whole body 0.2 0.8 3.1 0.8 0.2 0.7 0.4 1.3 -0.8 0.9 -1.8 0.4
Leg fat mass (left) 0.4 1.4 8.7 -0.6 -0.6 -1.1 3.0 0.1 -0.1 -0.8 0.3 -1.0
Arm predicted mass (left) 0.0 0.2 0.9 0.1 -0.3 -0.0 0.6 -0.6 0.6 0.1 0.9 0.2