TWAS hub - ACTN1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0548	0.0213	0.00019	-0.001	0.014	0.001	0.012	-0.002	5.8e-01	3.0e-03	2.1e-01	5.5e-03	7.4e-01
2	YFS	Blood	0.0319	0.0113	0.00041	0.016	0.016	0.016	0.019	0.014	3.9e-06	4.7e-06	4.8e-06	5.9e-07	1.8e-05
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0564	0.0256	0.00230	0.001	0.013	-0.002	NA	-0.001	2.6e-01	1.1e-02	9.6e-01	NA	4.4e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Frequency of tiredness / lethargy in last 2 weeks	7.1	11.5	18.2	2.9	2.8	4.3
Pain experienced in last month	6.8	11.3	12.5	-3.5	-3.0	-3.5
Neuroticism	6.1	14.6	19.8	4.4	4.1	2.6
Sensitivity / hurt feelings	5.8	9.9	19.0	4.4	2.8	1.7
Neck or shoulder pain in last month	5.7	8.1	15.7	4.0	1.2	2.7
Fed-up feelings	5.5	10.0	18.7	4.3	2.4	2.4
Eye problems/disorders: Diabetes related eye disease	5.4	5.9	13.0	3.6	2.1	0.6
Headache pain in last month	5.3	9.1	14.6	3.8	2.6	2.5
Depressed Affect (Nagel 2018)	5.2	10.8	22.0	4.7	2.4	2.2
Current tobacco smoking	5.2	8.5	16.7	4.1	1.5	2.6
Smoking status: Current	5.1	8.1	18.2	4.3	1.4	2.1
Medication: Cholesterol lowering	5.0	7.8	11.0	3.3	2.5	2.4
Overall health rating	5.0	10.7	26.4	1.7	1.7	5.1
Neuroticism (Nagel 2018)	4.7	11.1	20.0	4.5	3.4	1.4
Type 2 Diabetes (T2D) (2018)	4.5	8.4	13.0	3.5	3.6	0.2
Diabetes (mother)	4.5	5.7	9.4	3.1	2.7	-0.8
Diabetes diagnosed by doctor	4.5	7.3	11.3	3.2	3.4	0.5
Neuroticism score	4.4	9.3	13.1	3.6	2.6	2.8
Medication: Gliclazide	4.4	5.0	9.6	3.1	2.1	0.9
Qualifications: College or University degree	4.3	13.5	19.1	-3.4	-3.1	-4.4
Age at last live birth	4.3	6.2	12.2	-3.5	-1.2	-2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	4.2	5.6	7.6	2.8	1.6	2.6
Diabetes (self-reported)	4.2	6.5	11.6	2.8	3.4	0.1
Leg fat percentage (right)	4.1	14.8	22.2	4.7	4.1	2.3
Age at first live birth	3.9	6.9	12.2	-3.5	-0.7	-2.9
Pulse rate	3.8	6.4	11.6	3.4	2.0	1.9
Long-standing illness, disability or infirmity	3.8	5.8	9.8	2.5	-1.1	3.1
Leg fat percentage (left)	3.8	13.9	20.8	4.6	3.9	2.3
Osteoarthritis (self-reported)	3.6	4.7	6.8	2.6	-2.2	1.7
Depression (Nagel 2018)	3.5	5.2	9.4	3.1	2.0	1.5
Loneliness, isolation	3.4	4.6	7.1	2.7	1.9	1.8
Average weekly champagne plus white wine intake	3.4	4.7	8.0	-1.4	-2.0	-2.8
Stomach or abdominal pain in last month	3.3	4.2	9.0	3.0	1.9	0.3
Qualifications: NVQ or HND or HNC or equivalent	3.3	4.0	9.5	1.5	0.4	3.1
Body Mass Index (BMI) (2010)	3.2	4.4	7.1	2.7	2.5	0.3
Diverticular disease/diverticulitis (self-reported)	3.2	3.8	5.9	-2.4	-1.4	-2.0
Commuting to job workplace: Public transport	3.2	3.8	8.2	-1.8	0.0	-2.9
Medication: Paracetamol	3.1	5.1	12.2	1.8	0.2	3.5
Alcohol intake frequency.	3.1	7.1	9.7	2.9	1.8	3.1
Commuting to job workplace: Cycle	3.1	3.8	9.1	-1.3	-3.0	0.7
Medication: Metformin	3.0	4.2	7.9	2.8	2.1	0.2
Osteoporosis (self-reported)	3.0	3.7	8.7	-1.3	-3.0	-0.9
Miserableness	3.0	5.1	7.3	2.7	1.2	2.6
Reaction Time	2.9	5.5	7.7	-2.7	-2.8	-1.1
Nervous feelings	2.8	5.3	7.7	1.4	2.5	2.8
Heart attack	2.8	3.6	5.7	2.4	1.7	1.5
Medication for cholesterol, blood pressure or diabetes	2.8	4.7	11.0	-3.3	-1.6	-0.8
Body fat percentage	2.8	11.0	17.4	4.2	3.8	1.2
Leg fat mass (right)	2.8	10.8	15.4	3.9	3.9	1.4
Number of treatments/medications taken	2.7	4.9	8.4	2.3	0.9	2.9
Commuting to job workplace: Walk	2.7	2.9	5.8	-1.1	-1.3	-2.4
Verbal and Numeric Reasoning (VNR)	2.6	6.2	16.2	4.0	1.0	-1.1
Number of children fathered	2.6	3.0	7.8	-0.3	2.8	1.0
Financial situation satisfaction	2.6	3.2	8.5	-0.4	0.9	2.9
Leg fat mass (left)	2.6	10.3	14.9	3.8	3.9	1.4
Medication: Lansoprazole	2.5	2.8	4.0	1.8	1.2	2.0
Chest pain or discomfort	2.5	3.6	7.6	2.8	-0.8	1.6
Medication: Paracetamol	2.5	3.8	9.2	1.5	-0.1	3.0
Heart attack/myocardial infarction (self-reported)	2.5	3.3	4.5	2.1	1.9	1.3
Trunk fat percentage	2.4	9.5	15.2	3.9	3.6	0.8
Pulse wave Arterial Stiffness index	2.4	2.8	5.4	2.3	1.7	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.7	6.5	2.1	-0.4	2.5
Whole body fat mass	2.4	10.2	16.0	3.8	4.0	0.7
Mineral and other dietary supplements	2.4	3.3	5.7	2.0	2.4	0.1
Supplements: Fish oil (including cod liver oil)	2.4	3.1	5.8	-1.9	-2.4	-0.2
Lupus	2.3	3.5	6.7	1.7	2.6	0.9
Body mass index (BMI)	2.3	9.7	17.1	3.3	4.1	0.9
Illness, injury, bereavement, stress in last 2 years	2.3	2.9	5.7	-2.4	-1.7	0.2
Eye problems/disorders: Cataract	2.3	2.6	6.6	-1.1	-2.6	0.2
Heart disease (siblings)	2.3	2.8	4.3	2.1	1.9	-0.7
Age at First Birth	2.2	3.2	4.6	-2.0	-1.0	-2.1
Crohns Disease (2012)	2.2	3.5	9.1	-3.0	-1.0	-0.6
Medication for hormone replacement therapy	2.2	2.4	6.5	2.6	0.8	0.4
Supplements: Zinc	2.2	2.4	6.4	0.2	-2.5	-0.9
Pulse wave peak to peak time	2.2	2.6	4.9	-2.2	-1.6	-0.6
Medication: Omeprazole	2.2	2.6	5.6	2.4	1.1	1.0
Knee pain experienced in last month	2.2	3.5	9.3	0.8	0.6	3.0
Neuroticism (2016)	2.1	3.0	4.2	1.8	2.0	1.2
Bilateral oophorectomy (both ovaries removed)	2.1	2.5	5.3	2.3	0.9	1.1
Trunk fat mass	2.1	9.1	14.3	3.6	3.8	0.6
Waist circumference	2.1	7.6	12.9	3.6	3.1	0.3
Worry too long after embarrassment	2.1	3.5	3.6	1.8	1.9	1.9
Mood swings	2.1	3.7	8.2	2.9	1.2	1.2
Worry (Nagel 2018)	2.0	4.2	5.7	2.4	2.4	1.2
Hypothyroidism (self reported)	2.0	4.6	8.5	2.9	2.2	0.8
Tinnitus: Yes, but not now, but have in the past	2.0	2.1	2.3	1.5	1.5	1.3
Alcohol usually taken with meals	2.0	3.2	5.5	-2.3	-1.3	-1.5
Medication for pain relief, constipation, heartburn	2.0	3.4	5.2	-2.0	-1.1	-2.3
Leg pain on walking	2.0	2.5	6.3	1.1	-0.1	2.5
Medication: Aspirin	2.0	2.7	4.5	2.1	1.5	1.1
Medication: Bendroflumethiazide	2.0	3.1	7.2	1.3	0.6	2.7
Medication: Omeprazole (e.g. Zanprol)	2.0	2.5	4.2	2.1	1.7	0.6
Irritable Bowel Disease (IBD)	1.9	4.5	7.3	-2.4	-2.7	-0.5
HDL Cholesterol	1.9	3.2	8.9	0.8	-3.0	-0.1
Frequency of depressed mood in last 2 weeks	1.9	2.6	3.3	1.8	1.4	1.6
Arm fat percentage (right)	1.9	7.3	12.7	2.9	3.6	1.0
Arm fat mass (right)	1.9	7.7	14.2	2.9	3.8	0.6
Arm fat mass (left)	1.9	7.9	14.4	3.0	3.8	0.4
Rheumatoid Arthritis	1.8	2.5	4.1	2.0	1.6	1.0
BMI	1.8	10.3	13.8	3.4	3.7	2.4
Frequency of tenseness / restlessness in last 2 weeks	1.8	2.8	4.5	2.1	1.9	0.5
Illnesses of siblings	1.8	2.6	5.6	-2.4	-1.4	-0.5
Asthma	1.8	3.5	6.5	-1.6	-1.2	-2.5
Forced vital capacity (FVC), Best measure	1.8	6.5	10.0	-2.3	-3.2	-2.1
Number of full brothers	1.8	2.3	6.7	0.4	-0.2	2.6
Arm fat percentage (left)	1.8	7.1	12.3	2.9	3.5	0.6
Illnesses of father: None of the above (group 1)	1.8	2.3	5.6	-2.4	0.6	-0.8
Respiratory disease	1.7	3.8	5.5	-2.3	-1.3	-2.0
Relative age voice broke	1.7	2.6	3.7	-1.8	-1.9	-1.0
Fluid intelligence score	1.7	3.5	8.6	2.9	0.4	-1.3
Father’s age at death	1.7	2.3	3.9	-2.0	0.8	-1.5
Glaucoma (self-reported)	1.7	2.0	5.5	-2.4	-0.1	0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	5.6	-0.3	0.5	-2.4
Health satisfaction	1.7	2.2	4.5	1.3	0.6	2.1
Mean time to correctly identify matches	1.7	3.2	7.0	-2.6	-1.5	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.1	4.7	-0.6	1.0	2.2
Back pain experienced in last month	1.7	2.4	5.2	1.1	0.9	2.3
Type 2 Diabetes (T2D) (2012)	1.6	1.8	2.9	1.7	0.3	1.6
Allergy	1.6	3.7	5.5	1.8	1.6	2.3
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	4.5	2.1	-0.7	-0.4
Asthma (self-reported)	1.6	3.2	5.7	-1.5	-1.2	-2.4
Supplements: Calcium	1.6	1.7	3.9	0.5	-2.0	-1.0
Smoking Status	1.5	3.6	10.2	3.2	0.5	0.6
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	5.3	-0.0	-0.8	2.3
Had other major operations	1.5	1.9	3.2	1.4	1.8	-0.6
Pain all over the body in last month	1.5	1.6	2.4	1.1	1.2	1.6
Medication: Simvastatin	1.5	2.3	5.2	1.2	2.3	0.2
Hypothyroidism/myxoedema (self-reported)	1.5	2.8	7.2	2.7	0.7	0.9
Pulse rate, automated reading	1.5	4.8	6.7	2.6	2.3	1.6
Illnesses of siblings: Diabetes	1.5	1.8	3.7	1.9	1.1	0.7
Medication: Lisinopril	1.5	1.9	5.4	2.3	0.5	-0.3
Alcohol drinker status: Never	1.5	1.8	3.6	1.3	1.9	0.0
Alzheimer’s Disease (in mother)	1.4	1.6	2.7	-1.7	-1.3	-0.6
Triglycerides	1.4	2.3	4.0	0.8	2.0	1.5
Allergy or Eczema	1.4	3.7	5.2	-2.3	-1.7	-1.7
Lung FEV1/FVC ratio	1.4	6.9	17.4	1.8	4.2	-0.3
Financial difficulties in last 2 years	1.4	1.9	2.9	1.7	1.6	0.1
Weight	1.4	6.7	13.9	2.5	3.7	0.2
Hip circumference	1.4	6.2	10.1	2.8	3.2	0.6
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	3.2	1.3	0.2	-1.8
Shortness of breath walking on level ground	1.4	1.6	4.8	-0.2	-0.2	2.2
Heart disease (mother)	1.4	1.7	4.6	-0.6	-0.4	-2.1
Number of full sisters	1.4	1.7	3.7	1.0	0.7	1.9
Supplements: Vitamin C	1.4	1.6	4.1	-0.4	-2.0	0.7
Average weekly red wine intake	1.4	2.1	4.8	-1.1	-0.5	-2.2
Qualifications: nursing, teaching	1.4	2.2	3.7	-0.6	-1.6	-1.9
Medication: Aspirin	1.4	1.8	3.6	1.9	1.3	0.4
Risk taking	1.4	2.0	2.7	0.8	-1.7	-1.6
Vascular/heart problems diagnosed by doctor	1.4	3.8	8.5	-2.9	-1.4	-1.0
Crohns Disease (2017)	1.3	2.8	5.1	-2.2	-1.6	-0.9
Ulcerative Colitis	1.3	1.9	3.8	-1.9	-1.3	-0.4
Taking other prescription medications	1.3	2.0	4.0	2.0	-1.0	1.0
Worrier / anxious feelings	1.3	2.4	4.5	1.4	2.1	0.8
Tense / ‘highly strung’	1.3	2.2	3.3	1.8	1.8	-0.2
Loud music exposure frequency	1.3	1.4	4.1	0.4	-0.1	-2.0
Medication: Ventolin 100micrograms inhaler	1.3	1.6	3.1	-1.0	-1.8	-1.0
Illnesses of father: Heart disease	1.3	1.7	3.2	1.8	-1.4	-0.0
Intelligence (Savage-Jansen 2018)	1.2	3.8	5.8	2.4	0.4	-2.4
Major Depression (MDD)	1.2	1.5	4.5	0.0	-2.1	-0.2
Blood Red Count	1.2	11.3	28.0	5.3	0.9	2.3
Hand grip strength (left)	1.2	3.1	5.4	1.2	2.3	1.6
Diabetes (father)	1.2	1.5	4.5	2.1	0.3	-0.1
Maternal smoking around birth	1.2	1.7	2.5	1.6	1.1	1.2
Forced vital capacity (FVC)	1.2	4.7	7.3	-1.6	-2.7	-2.1
Gout (self-reported)	1.2	1.6	1.9	-1.1	-1.4	-1.3
Medication for cholesterol	1.2	1.8	4.5	-2.1	-0.3	-0.8
Number of self-reported non-cancer illnesses	1.2	2.1	6.3	2.5	0.3	0.3
Fractured/broken bones in last 5 years	1.2	1.6	3.6	1.0	-1.9	-0.3
Ulcerative Colitis (UC)	1.1	2.0	3.9	-1.3	-2.0	0.7
Mouth/teeth dental problems	1.1	1.7	3.4	-0.2	-1.3	-1.8
Medication: Ramipril	1.1	1.5	3.9	0.1	2.0	0.7
Time employed in main current job	1.1	1.3	2.7	-1.6	1.0	-0.5
Friendships satisfaction	1.1	1.3	3.1	1.8	0.5	0.8
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	3.9	-0.0	-2.0	-1.1
Pain type(s) experienced in last month: Hip pain	1.1	1.4	3.6	0.2	0.7	1.9
Cardiovascular Disease	1.0	3.3	9.2	3.0	0.6	-0.5
Lung FVC	1.0	4.9	7.5	-0.3	-2.7	-2.7
Severe depression (siblings)	1.0	1.1	2.2	1.0	0.4	1.5
Townsend deprivation index at recruitment	1.0	1.3	3.6	0.1	-0.7	1.9
Hayfever, allergic rhinitis or eczema	1.0	2.1	2.6	-1.4	-1.6	-1.3
Multivitamins +/- minerals	1.0	1.3	3.3	0.6	1.8	0.4
Impedance of arm (right)	1.0	4.6	8.8	-2.2	-3.0	0.2
Alcohol intake versus 10 years previously	1.0	1.5	3.6	1.0	-0.1	1.9
Mouth/teeth dental problems: Dentures	1.0	1.7	2.1	1.4	0.9	1.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.3	3.5	-1.9	-1.8	-1.8
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	3.6	-0.1	-1.1	-1.9
High blood pressure (siblings)	1.0	1.4	2.0	1.4	1.4	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.3	-0.7	-1.5	1.1
Hypertension (Self-reported)	1.0	2.8	6.2	2.5	1.4	-0.6
Handedness (chirality/laterality): Left-handed	1.0	1.2	3.1	1.8	0.1	-0.7
Eye problems/disorders: Glaucoma	1.0	1.2	3.3	-1.8	0.1	0.6
Ever had hysterectomy (womb removed)	0.9	1.0	2.0	1.4	0.6	0.8
Medication: Levothyroxine sodium	0.9	1.5	3.4	1.8	1.1	-0.2
Chronic bronchitis/emphysema (father)	0.9	1.1	1.7	0.2	1.3	1.3
Had menopause	0.9	1.1	2.6	0.2	0.8	-1.6
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	2.2	1.5	-0.1	1.1
Impedance of arm (left)	0.9	4.2	8.2	-1.9	-2.9	-0.9
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.1	0.5	1.0	1.4
Medication: Blood pressure	0.9	1.6	4.4	2.1	0.7	0.2
Breast cancer (self-reported)	0.9	1.1	2.7	-0.6	-0.4	1.7
High cholesterol (Self-reported)	0.9	1.5	2.2	1.5	0.7	1.4
Age started oral contraceptive pill	0.9	1.2	2.2	-1.5	-0.7	-0.9
Myopia	0.9	1.4	2.9	1.7	0.8	0.7
Breast Cancer	0.8	2.0	5.1	0.9	0.5	-2.3
Blood Platelet Count	0.8	9.4	17.1	-1.5	4.1	3.0
Medication: Co-codamol	0.8	1.0	1.3	1.1	-0.7	1.1
Serious illness, injury or assault to yourself	0.8	1.0	2.4	1.5	0.5	-0.7
High blood pressure	0.8	2.2	4.9	2.2	1.3	-0.2
Medication: Atenolol	0.8	1.0	2.2	0.0	0.8	1.5
Hearing difficulty/problems with background noise	0.8	1.3	2.0	0.3	1.4	-1.4
Qualifications: A levels/AS levels or equivalent	0.8	1.7	2.4	-1.1	-1.3	-1.5
Length of working week for main job	0.8	0.9	1.1	1.0	-0.7	-1.1
Pulse wave reflection index	0.8	1.0	1.7	-1.3	-0.7	-0.9
Birth weight	0.8	1.6	4.7	-2.2	-0.0	0.5
Eye problems/disorders: None of the above	0.8	0.9	1.3	1.1	0.5	-1.1
Medication: Ibuprofen	0.8	1.0	2.0	-1.0	0.1	1.4
Bipolar Disorder (2018)	0.7	1.1	1.8	-0.4	-1.2	1.4
Coronary Artery Disease (CAD)	0.7	0.8	1.1	1.1	0.7	1.0
Relative age of first facial hair	0.7	1.4	3.5	-1.9	-0.8	0.4
Pack years adult smoking proportion	0.7	1.0	2.1	0.8	0.6	1.4
Hand grip strength (right)	0.7	2.0	5.4	0.5	2.3	0.5
Impedance of leg (left)	0.7	3.2	4.7	1.4	-2.2	1.8
Hair/balding pattern: Pattern 2	0.7	0.9	1.3	0.9	-1.1	-0.8
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	3.9	-1.3	-1.3	-2.0
Happiness	0.7	0.9	1.3	0.4	1.1	1.2
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.3	-1.0	-0.7	1.2
Breastfed as a baby	0.7	0.8	2.2	0.5	1.5	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.0	-0.5	-1.4	0.2
Medication: Atorvastatin	0.7	0.8	1.3	1.1	-0.2	1.1
Average weekly beer plus cider intake	0.7	1.0	1.3	1.1	-0.7	1.1
Irritability	0.7	1.3	1.6	1.1	1.0	1.3
Ever depressed for a whole week	0.7	0.9	1.2	1.1	1.1	0.4
Unable to work because of sickness or disability	0.7	0.9	1.6	1.0	-0.1	1.3
Chronotype (morning person)	0.6	1.3	3.2	-1.8	-0.7	0.5
Vitamin and mineral supplements	0.6	0.8	1.2	-1.1	-1.0	0.1
Hair/balding pattern: Pattern 3	0.6	0.9	1.7	-0.4	1.3	-0.9
Hair/balding pattern: Pattern 4	0.6	1.6	3.0	1.3	1.7	-0.1
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.3	-1.2	0.9	0.4
Medication: Amlodipine	0.6	0.8	2.3	0.2	0.1	-1.5
Migraine (self-reported)	0.6	0.8	1.2	1.1	1.1	0.1
Arm predicted mass (right)	0.6	3.1	6.3	1.7	2.5	-0.1
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.2	1.0	0.1	1.1
Wears glasses or contact lenses	0.6	0.6	1.3	-1.1	0.3	0.7
Hearing aid user	0.6	0.6	1.3	-0.0	-1.2	0.8
Medication: Blood pressure	0.6	1.1	1.8	1.0	0.6	1.4
Arm predicted mass (left)	0.6	3.0	6.3	1.6	2.5	0.2
Schizophrenia (2018)	0.5	1.1	1.6	-1.3	1.0	-0.8
Alzheimer’s Disease (in father)	0.5	0.5	0.9	-0.3	0.7	1.0
Alzheimer’s Disease (including proxy)	0.5	0.8	1.3	-1.1	-0.6	-0.8
LDL Cholesterol	0.5	0.7	1.9	0.4	-0.3	1.4
Impedance of leg (right)	0.5	2.5	2.7	1.5	-1.7	1.6
Number of incorrect matches in round	0.5	0.8	1.5	0.9	0.5	1.2
Past tobacco smoking	0.5	0.9	1.6	-1.3	0.4	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.9	0.5	-0.2	1.7
Wheeze or whistling in the chest in last year	0.5	1.0	2.7	1.6	-0.2	-0.4
Guilty feelings	0.5	0.7	1.1	1.1	1.0	-0.1
Arm fat-free mass (left)	0.5	2.7	6.1	1.5	2.5	0.1
Fasting Glucose	0.4	0.5	1.2	0.5	0.4	-1.1
Schizophrenia (2014)	0.4	0.9	1.6	-1.3	1.0	0.1
Blood Eosinophil Count	0.4	3.1	7.0	0.6	-1.4	-2.6
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.1	1.1	0.2	-0.4
Leg fat-free mass (left)	0.4	2.1	5.2	0.2	2.3	-1.0
Leg predicted mass (left)	0.4	2.1	5.2	0.2	2.3	-1.0
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.8	-0.8	-0.9	-0.2
Falls in the last year	0.4	0.6	1.5	-1.2	-0.5	0.1
Number of live births	0.4	0.6	1.1	-1.0	-0.3	0.8
Arm fat-free mass (right)	0.4	2.3	4.9	1.3	2.2	-0.3
Emphysema/chronic bronchitis	0.4	0.5	0.9	0.6	-0.5	1.0
Comparative height size at age 10	0.4	2.1	3.0	-1.7	-0.7	-1.6
Smoking status: Previous	0.4	0.5	0.9	-0.1	-0.8	-1.0
Basal metabolic rate	0.4	2.4	6.1	0.8	2.5	-0.5
Number of operations (self-reported)	0.4	0.6	1.3	1.1	-0.0	0.8
Alcohol drinker status: Previous	0.4	0.4	0.6	0.4	-0.8	0.7
Pack years of smoking	0.4	0.6	1.5	0.1	0.7	1.2
Impedance of whole body	0.4	2.1	6.2	-0.2	-2.5	0.4
Ovarian Cancer	0.3	0.4	1.1	-0.2	0.0	-1.0
Bipolar Disorder (2011)	0.3	0.2	0.4	-0.4	-0.6	0.5
Height	0.3	4.9	9.4	-1.9	-1.2	-3.1
Average weekly spirits intake	0.3	0.3	0.5	0.7	0.2	-0.6
Age when periods started (menarche)	0.3	0.7	2.0	-0.1	-0.4	1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.7	0.5	-0.2	1.3
Noisy workplace	0.3	0.4	0.8	-0.9	-0.6	-0.0
Prospective memory result	0.3	0.3	0.8	-0.9	0.4	0.3
Illnesses of mother	0.3	0.4	1.0	-0.5	-1.0	-0.1
Exposure to tobacco smoke at home	0.3	0.4	0.6	-0.8	-0.7	-0.3
Blood clot in the leg (DVT)	0.3	0.4	0.8	0.1	0.6	0.9
Exposure to tobacco smoke outside home	0.3	0.4	1.1	0.1	-1.1	0.2
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.9	-0.3	1.0	-0.3
Leg fat-free mass (right)	0.3	1.7	3.9	-0.2	2.0	-1.1
Whole body water mass	0.3	1.4	4.0	0.2	2.0	-0.6
Leg predicted mass (right)	0.3	1.7	3.8	-0.2	1.9	-1.1
Ever taken oral contraceptive pill	0.3	0.3	0.6	-0.5	-0.5	-0.7
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.0	-1.0	-0.1	0.1
Diastolic blood pressure, automated reading	0.3	1.1	2.9	1.7	-0.2	0.5
Basal cell carcinoma (self-reported)	0.3	0.4	0.9	0.9	0.2	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.8	-0.4	0.5	0.9
Bipolar Disorder or Schizophrenia	0.2	0.6	1.6	-1.3	0.1	0.3
Prostate Cancer	0.2	0.3	0.7	0.8	0.1	-0.3
Mean Putamen Volume	0.2	0.2	0.6	0.2	-0.0	-0.8
HbA1C	0.2	0.2	0.6	-0.2	-0.8	-0.1
Primary Biliary Cirrhosis	0.2	0.3	0.5	-0.7	0.7	0.2
Blood White Count	0.2	1.2	1.6	-0.7	1.2	1.3
Systolic Blood Pressure	0.2	1.2	2.8	-1.7	-0.9	0.0
Systolic blood pressure, automated reading	0.2	0.7	2.1	-1.4	0.2	-0.1
Angina	0.2	0.3	0.6	0.8	-0.5	0.0
Supplements: Glucosamine	0.2	0.3	0.5	0.7	-0.5	0.2
High blood pressure (mother)	0.2	0.3	0.5	-0.4	0.6	0.7
Qualifications: None of the above	0.2	0.5	0.9	0.8	0.1	0.9
Trunk fat-free mass	0.2	1.1	3.1	-0.0	1.8	-0.5
Depression (self-reported)	0.2	0.2	0.4	-0.7	0.2	-0.3
Lung cancer (father)	0.2	0.2	0.4	0.2	0.4	0.6
Trunk predicted mass	0.2	1.0	2.8	-0.0	1.7	-0.4
Standing height	0.2	2.1	3.5	-1.6	-0.6	-1.9
Comparative body size at age 10	0.2	0.5	0.7	0.0	0.9	-0.9
Angina (self-reported)	0.2	0.3	0.6	0.8	-0.6	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.8	0.2	0.5	-0.9
Whole body fat-free mass	0.2	1.4	3.7	0.2	1.9	-0.6
Mother’s age at death	0.2	0.2	0.4	-0.4	-0.4	-0.6
Illnesses of father: High blood pressure	0.2	0.3	0.4	0.6	-0.3	-0.6
Ever smoked	0.2	0.4	0.7	0.6	0.1	-0.8
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.6	0.5	-0.1	-0.7
Cholesterol lowering medication	0.2	0.2	0.5	0.4	-0.2	-0.7
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	0.6	0.3	-0.1
Heel T-Score	0.1	0.8	2.4	0.3	-0.1	-1.6
Waist Hip Ratio (WHR)	0.1	0.7	1.4	0.7	-0.2	-1.2
Hair Pigment	0.1	1.4	4.0	-0.6	-0.0	2.0
Tanning	0.1	0.8	2.3	0.3	1.5	0.4
Hearing difficulty/problems: Yes	0.1	0.2	0.6	0.3	0.7	0.0
Average weekly fortified wine intake	0.1	0.1	0.2	0.5	-0.2	0.0
Qualifications: CSEs or equivalent	0.1	0.2	0.3	-0.2	-0.5	0.5
Sitting height	0.1	0.4	0.9	0.3	0.3	-1.0
Birth weight of first child	0.1	0.2	0.3	-0.5	-0.3	-0.5
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	-0.4	0.4	0.1
Medication: Allopurinol	0.1	0.1	0.4	0.1	-0.7	0.0
Medication: Seretide 50 evohaler	0.1	0.1	0.4	-0.2	-0.6	-0.0
Suffer from ‘nerves’	0.1	0.1	0.3	0.1	0.6	0.1
Family relationship satisfaction	0.1	0.2	0.4	-0.2	-0.4	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	-0.0	0.4	0.4
Ever had bowel cancer screening	0.1	0.1	0.3	-0.5	0.0	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.6	0.8	0.3	-0.2
Peak expiratory flow (PEF)	0.0	0.0	0.0	0.2	-0.1	0.0
Had major operations	0.0	0.0	0.0	-0.2	0.0	0.1

Hub : Genes

ACTN1

Models

Trait associations