Hub : Genes

ACTR5

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0780 0.0330 2.4e-03 0.051 0.012 0.024 0.023 0.043 8.2e-07 1.0e-02 5.6e-04 6.7e-04 5.8e-06
2 GTEx Artery Aorta 0.2380 0.0580 1.5e-07 0.203 NA 0.182 NA 0.199 1.9e-11 NA 2.8e-10 NA 3.3e-11
3 GTEx Brain Cerebellar Hemisphere 0.3120 0.1150 9.3e-03 0.124 NA 0.088 NA 0.090 4.5e-04 NA 3.0e-03 NA 2.6e-03
4 GTEx Breast Mammary Tissue 0.1200 0.0500 4.2e-03 0.127 NA 0.103 NA 0.111 4.6e-07 NA 5.9e-06 NA 2.5e-06
5 GTEx Breast Mammary Tissue (Male) 0.0352 0.0504 2.8e-01 0.020 NA -0.011 NA -0.006 1.1e-01 NA 7.2e-01 NA 4.7e-01
6 GTEx Breast Mammary Tissue (Female) 0.1454 0.0722 1.4e-02 0.124 NA 0.074 NA 0.119 1.5e-04 NA 3.2e-03 NA 2.1e-04
7 GTEx Cells EBV-transformed lymphocytes 0.2820 0.0870 2.2e-04 0.100 NA 0.153 NA 0.160 3.8e-04 NA 1.1e-05 NA 6.8e-06
8 GTEx Esophagus Mucosa 0.1110 0.0410 1.6e-03 0.085 NA 0.068 NA 0.096 2.5e-06 NA 2.4e-05 NA 5.5e-07
9 GTEx Lung 0.1014 0.0354 3.1e-04 0.132 NA 0.121 NA 0.124 2.6e-10 NA 1.7e-09 NA 9.9e-10
10 GTEx Skin Not Sun Exposed Suprapubic 0.1120 0.0470 6.0e-03 0.063 NA 0.051 NA 0.061 2.3e-04 NA 8.5e-04 NA 3.1e-04
11 GTEx Skin Sun Exposed Lower leg 0.1170 0.0330 7.8e-07 0.117 NA 0.109 NA 0.124 6.4e-10 NA 2.5e-09 NA 2.0e-10
12 GTEx Testis 0.5920 0.0520 0.0e+00 0.605 NA 0.632 NA 0.633 4.6e-33 NA 1.8e-35 NA 1.5e-35
13 GTEx Whole Blood 0.0590 0.0240 3.6e-03 0.080 NA 0.044 NA 0.070 7.4e-08 NA 6.2e-05 NA 4.9e-07
14 METSIM Adipose 0.0656 0.0229 2.5e-05 0.041 0.024 0.025 0.026 0.027 8.9e-07 1.2e-04 9.8e-05 6.5e-05 6.0e-05
15 YFS Blood 0.1631 0.0270 0.0e+00 0.140 0.160 0.144 0.160 0.154 1.4e-43 6.8e-50 1.3e-44 7.3e-50 4.2e-48
16 TCGA Brain Lower Grade Glioma 0.0412 0.0194 6.6e-05 0.059 0.050 0.048 NA 0.056 3.1e-07 2.2e-06 3.2e-06 NA 5.4e-07
17 TCGA Liver Hepatocellular Carcinoma 0.1460 0.0700 5.0e-04 0.004 0.059 0.044 NA 0.047 2.0e-01 9.4e-04 3.8e-03 NA 2.8e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Bipolar Disorder (2018) 2.2 3.6 6.1 1.3 2.2 1.7 1.6 0.0 2.0 1.6 1.9 2.0 2.3 2.3 -1.9 2.0 2.3 2.5 -1.9 0.9
Bipolar Disorder or Schizophrenia 7.1 17.4 35.5 1.4 4.6 3.1 3.5 0.0 4.1 3.4 3.1 4.1 5.3 4.6 -5.3 4.2 4.7 6.0 -5.5 3.6
Depressed Affect (Nagel 2018) 0.4 0.9 3.3 1.1 0.7 1.8 1.4 0.0 1.1 0.7 0.8 1.3 -0.4 -0.0 0.1 1.2 0.7 -0.4 1.0 -0.6
Depression (Nagel 2018) 0.4 0.5 1.8 -1.3 -0.8 -0.2 -0.7 0.0 -0.8 -0.7 -0.9 -0.9 -0.4 -0.7 -0.4 -0.9 -0.5 -0.7 -0.5 0.8
Intelligence (Savage-Jansen 2018) 0.2 0.5 1.4 -0.2 -0.8 -1.2 -0.7 0.0 -0.6 -1.0 -0.8 -0.7 -0.5 -0.9 0.7 -0.6 -0.7 -0.6 0.4 -1.0
Neuroticism (Nagel 2018) 1.1 2.5 5.3 2.0 1.6 2.3 2.3 0.0 2.0 1.5 1.6 2.2 0.7 1.3 -0.4 2.2 1.7 0.7 0.4 -1.1
Schizophrenia (2018) 7.2 15.0 32.3 0.7 4.1 2.6 3.2 0.0 3.6 3.1 2.4 3.7 4.9 4.1 -5.2 3.8 4.2 5.7 -5.5 3.9
Schizophrenia vs Biploar Disorder 0.5 0.7 2.8 -0.3 0.8 0.4 0.4 0.0 0.4 0.8 0.2 0.5 1.0 0.6 -1.4 0.5 0.8 1.5 -1.7 0.7
Worry (Nagel 2018) 2.0 4.2 8.1 2.4 2.2 2.1 2.8 0.0 2.6 2.3 2.0 2.7 2.1 2.1 -0.7 2.6 2.3 1.6 -0.5 -1.2
Alzheimer’s Disease (in mother) 1.0 1.2 2.8 1.6 1.3 1.7 1.3 0.0 1.4 0.8 1.1 1.4 1.1 0.5 -0.3 1.4 1.3 0.4 -0.2 -0.7
Alzheimer’s Disease (in father) 0.3 0.3 1.1 0.7 0.2 -0.1 -0.1 0.0 -0.1 0.7 0.6 0.0 1.0 0.9 0.5 0.0 0.2 -1.0 0.1 -0.7
Alzheimer’s Disease (including proxy) 0.1 0.1 0.4 0.6 -0.2 0.0 -0.3 0.0 -0.2 0.0 -0.0 -0.1 -0.0 -0.3 0.2 -0.1 -0.1 -0.6 0.2 -0.5
Crohns Disease (2017) 0.2 0.4 2.1 -0.5 0.5 -0.0 0.0 0.0 0.3 0.0 -0.7 0.2 0.3 -0.0 -1.4 0.3 0.5 1.2 -1.5 0.4
Irritable Bowel Disease (IBD) 1.2 2.9 10.8 -0.7 1.7 1.1 1.2 0.0 1.6 1.1 -0.1 1.5 1.2 1.3 -3.3 1.6 1.8 2.5 -3.1 1.3
Ulcerative Colitis (UC) 2.2 4.2 12.4 -0.4 2.2 1.9 1.9 0.0 2.2 1.6 0.5 2.1 1.4 1.9 -3.5 2.2 2.3 2.6 -3.3 1.1
Major Depression (MDD) 2.0 2.4 4.8 0.8 1.8 2.2 1.8 0.0 1.9 1.5 1.6 1.9 1.2 1.8 -1.6 1.9 1.8 0.7 -1.5 -0.0
Reaction Time 1.0 1.9 5.5 -0.5 1.3 1.1 1.1 0.0 1.2 0.4 0.8 1.2 1.2 1.2 -2.3 1.2 1.4 2.2 -2.1 1.6
Verbal and Numeric Reasoning (VNR) 0.3 0.8 2.7 1.0 0.9 0.4 1.1 0.0 1.1 0.9 0.4 1.0 1.0 1.2 -0.5 1.0 1.0 -0.2 -0.7 -1.6
Breast Cancer 0.2 0.4 0.6 -0.4 -0.7 -0.7 -0.6 0.0 -0.7 -0.3 -0.5 -0.7 -0.5 -0.8 0.8 -0.7 -0.7 -0.8 0.8 -0.0
Ovarian Cancer 2.5 3.2 4.6 -1.2 -2.0 -1.8 -1.8 0.0 -2.1 -1.8 -2.0 -2.0 -2.0 -2.0 1.6 -2.0 -1.9 -2.2 1.4 -1.5
Prostate Cancer 0.2 0.2 0.9 0.9 -0.1 -0.6 -0.3 0.0 -0.3 -0.2 0.0 -0.3 0.3 0.0 0.7 -0.3 -0.1 0.8 0.4 -1.0
Age at First Birth 1.2 1.8 4.5 0.3 -1.3 -0.7 -0.6 0.0 -1.1 -1.3 -0.8 -1.3 -1.1 -1.5 2.0 -1.3 -1.3 -2.1 2.0 -1.7
Bipolar Disorder (2011) 1.6 1.6 3.6 1.2 1.4 1.1 1.3 0.0 1.4 1.1 1.4 1.4 1.8 1.4 -0.7 1.4 1.4 1.9 -0.8 -0.2
Body Mass Index (BMI) (2010) 0.5 0.6 1.3 1.0 1.0 0.9 0.6 0.0 0.9 0.8 0.8 1.0 1.0 0.7 -0.4 1.1 1.1 0.2 -0.5 -0.5
Coronary Artery Disease (CAD) 0.3 0.4 1.1 -0.2 -0.3 -1.1 -0.8 0.0 -0.9 -0.9 -0.7 -0.8 -0.8 0.2 0.2 -0.8 -0.4 -0.3 -0.2 -0.9
Crohns Disease (2012) 0.3 0.5 1.5 -0.9 -0.5 -0.9 -0.8 0.0 -0.6 -0.6 -1.2 -0.6 -0.5 -0.4 -0.5 -0.6 -0.4 0.9 -0.5 0.5
Mean Putamen Volume 2.3 2.6 5.0 1.5 2.0 1.9 1.9 0.0 1.9 1.7 2.2 1.7 2.1 1.6 -1.0 1.7 1.9 1.0 -1.2 -0.5
Fasting Glucose 0.7 0.8 2.6 -0.9 -1.0 -0.6 -1.6 0.0 -1.3 -0.5 -1.4 -1.4 -0.3 -0.4 -0.3 -1.3 -0.6 0.2 -0.1 0.8
HbA1C 0.9 1.0 3.3 0.6 1.1 1.8 0.8 0.0 0.9 -0.1 0.6 0.7 1.4 1.1 -1.4 0.7 1.3 1.1 -1.1 -0.6
HDL Cholesterol 0.3 0.5 1.3 -1.1 -0.7 -0.9 -0.6 0.0 -0.7 -0.3 -1.1 -0.8 -0.7 -0.2 -0.1 -0.8 -0.6 -0.9 -0.4 -0.0
LDL Cholesterol 0.0 0.1 0.4 -0.3 -0.1 -0.2 -0.3 0.0 -0.2 -0.1 -0.1 -0.2 -0.4 0.3 -0.3 -0.2 -0.0 0.4 -0.1 0.6
Lupus 0.1 0.1 0.7 0.3 -0.1 0.0 -0.2 0.0 -0.2 -0.3 -0.0 -0.1 -0.4 -0.1 0.5 -0.1 -0.2 0.2 0.8 -0.0
Neuroticism (2016) 0.9 1.4 3.3 1.2 1.4 1.8 1.7 0.0 1.5 0.9 1.0 1.5 0.3 1.0 -0.8 1.6 1.4 0.7 -0.5 -0.5
Primary Biliary Cirrhosis 0.3 0.5 3.9 -0.4 -0.6 -0.0 -0.6 0.0 -0.4 -0.6 -0.3 -0.3 -0.6 -0.5 0.5 -0.4 -0.6 -2.0 0.8 0.2
Rheumatoid Arthritis 0.3 0.5 1.6 -0.9 -0.6 -0.6 -0.8 0.0 -0.7 -0.2 -1.2 -0.7 -0.5 -0.4 -0.3 -0.7 -0.6 -1.0 -0.4 0.8
Schizophrenia (2014) 5.1 11.3 26.0 0.2 3.5 1.9 2.4 0.0 3.1 2.4 1.8 3.2 4.1 3.3 -4.9 3.3 3.6 5.1 -5.0 3.7
Triglycerides 0.3 0.5 1.6 -0.4 -0.6 -1.2 -0.6 0.0 -0.6 -1.3 -0.6 -0.5 -0.2 -0.7 0.1 -0.5 -0.6 1.1 0.2 0.8
Type 2 Diabetes (T2D) (2012) 1.2 1.3 4.2 0.3 -1.1 -0.9 -1.0 0.0 -0.9 -1.1 -0.8 -0.9 -0.6 -0.7 1.8 -0.9 -1.2 -1.9 1.5 -2.1
Ulcerative Colitis 1.0 1.5 5.2 -0.5 1.1 0.7 0.8 0.0 1.0 1.6 -0.2 0.8 0.9 1.5 -2.1 0.9 1.1 1.8 -2.3 0.4
Blood Eosinophil Count 0.3 2.1 5.5 0.9 1.7 1.7 1.3 0.0 1.3 1.4 1.1 1.2 2.4 1.4 -1.4 1.2 1.6 1.8 -1.8 1.1
Blood Platelet Count 0.1 0.9 3.8 -0.8 -0.9 -0.6 -0.7 0.0 -0.6 0.2 -1.9 -0.7 -1.3 -0.8 0.4 -0.6 -1.0 -1.5 0.6 -1.4
Blood Red Count 0.5 5.3 10.2 1.2 2.8 1.6 2.2 0.0 2.3 2.3 2.2 2.2 2.9 2.8 -2.5 2.2 2.8 2.8 -3.2 0.6
Blood White Count 0.0 0.2 1.0 -0.1 0.2 0.3 0.3 0.0 0.3 0.4 -1.0 0.3 -0.1 -0.4 -0.8 0.4 0.4 0.8 -0.6 -0.2
Heel T-Score 0.1 1.2 5.8 1.2 1.1 -0.8 0.4 0.0 0.6 1.7 1.1 0.6 1.3 1.4 -0.0 0.6 0.6 2.4 -0.6 -1.1
BMI 0.5 2.9 6.4 -0.9 -1.8 -1.6 -1.7 0.0 -1.9 -0.9 -2.2 -1.8 -2.5 -2.4 1.5 -1.8 -1.8 -1.5 1.7 -1.1
Height 0.1 2.4 9.9 0.6 1.3 -0.1 0.8 0.0 0.8 0.7 0.9 0.4 3.1 2.4 -1.4 0.5 1.4 2.8 -2.7 0.9
Waist Hip Ratio (WHR) 0.5 2.3 6.3 0.8 1.7 1.7 1.6 0.0 1.7 2.5 1.0 1.6 1.4 2.0 -1.6 1.7 1.6 -0.6 -1.3 -1.1
Systolic Blood Pressure 0.1 0.4 2.0 -0.9 0.2 -0.1 0.2 0.0 0.3 0.2 -0.4 0.3 0.2 0.4 -1.2 0.4 0.2 1.4 -1.0 0.7
Smoking Status 3.2 7.8 14.3 1.7 3.2 2.1 2.7 0.0 3.0 3.1 1.4 2.8 3.3 3.2 -3.4 2.9 3.3 3.8 -3.7 0.5
Allergy or Eczema 0.2 0.6 2.4 0.8 0.6 1.5 0.7 0.0 0.8 0.3 1.5 0.9 0.4 0.6 0.3 0.8 0.5 -0.5 0.7 0.8
Cardiovascular Disease 0.2 0.8 5.1 1.5 0.3 0.0 0.2 0.0 0.1 0.9 1.1 0.2 0.1 0.5 1.4 0.1 0.1 0.3 1.1 -2.3
Hypothyroidism (self reported) 0.5 1.2 1.9 0.3 1.1 1.4 1.3 0.0 1.3 1.3 1.3 1.3 1.1 1.2 -1.0 1.3 1.2 0.3 -1.1 0.1
Respiratory disease 0.1 0.2 1.0 -0.7 -0.1 -0.3 -0.5 0.0 -0.4 -0.5 -0.1 -0.3 -0.1 -0.2 -0.3 -0.3 -0.2 -0.6 -0.2 1.0
Type 2 Diabetes (T2D) (2018) 0.6 1.1 4.1 2.0 1.0 1.6 1.3 0.0 1.0 1.0 1.6 1.0 0.9 0.4 0.6 0.9 0.8 0.3 0.7 -0.3
Lung FEV1/FVC ratio 0.1 0.5 3.3 0.5 0.0 0.5 0.3 0.0 0.2 0.8 0.1 0.1 0.1 1.0 0.7 0.1 0.1 -1.6 0.6 -1.8
Lung FVC 0.1 0.5 2.9 1.2 -0.3 0.2 -0.1 0.0 -0.3 0.1 -0.4 -0.3 -0.5 0.1 1.2 -0.2 -0.1 -0.8 1.0 -1.7
Neuroticism 0.9 2.1 4.9 1.7 1.5 2.2 2.2 0.0 2.0 1.3 1.1 2.1 0.5 1.0 -0.8 2.1 1.6 0.7 0.1 -0.7
Chronotype (morning person) 0.5 1.1 3.3 -0.5 -1.0 -0.5 -0.5 0.0 -0.7 -0.1 -1.4 -0.8 -1.3 -1.4 0.9 -0.8 -1.2 -1.6 1.0 -1.8
Hair Pigment 0.0 1.3 3.9 0.7 -1.0 -2.0 -1.6 0.0 -1.5 -1.2 -0.7 -1.5 0.4 -0.6 1.7 -1.5 -1.1 0.3 0.5 -0.7
Tanning 0.5 6.0 12.1 0.7 2.9 2.8 2.3 0.0 2.7 2.5 1.7 2.6 2.5 2.4 -3.5 2.7 2.9 1.6 -3.2 2.0
Hand grip strength (left) 0.4 1.1 2.6 0.4 -1.1 -0.6 -0.6 0.0 -1.0 -1.0 -1.5 -1.0 -0.7 -1.2 1.5 -1.0 -1.1 -1.2 1.4 -1.6
Number of treatments/medications taken 0.4 0.6 1.4 -0.8 -0.9 -0.3 -0.7 0.0 -0.8 -0.8 -0.6 -0.7 -1.1 -1.0 0.7 -0.8 -0.9 -1.2 0.8 -0.3
Average weekly spirits intake 2.1 2.6 4.5 -0.6 -1.7 -1.5 -2.0 0.0 -1.8 -2.0 -1.9 -1.6 -2.1 -2.1 1.6 -1.6 -1.8 -1.3 1.8 -0.2
Sensitivity / hurt feelings 0.3 0.4 1.3 0.6 0.6 1.0 1.0 0.0 0.8 0.6 0.2 0.9 -0.3 0.2 -0.1 0.9 0.5 0.0 0.5 -1.1
Frequency of depressed mood in last 2 weeks 0.6 0.8 3.1 -0.4 0.8 0.8 0.6 0.0 0.6 0.4 0.9 0.6 0.9 0.5 -1.2 0.5 0.8 1.3 -1.3 1.8
Hearing difficulty/problems: Yes 0.7 1.0 5.7 1.9 -0.0 0.6 0.4 0.0 0.0 0.5 0.6 0.0 -0.3 0.0 1.8 -0.0 -0.0 -0.7 1.7 -2.4
Relative age of first facial hair 0.7 1.4 9.5 1.5 -0.4 0.1 0.7 0.0 0.2 0.8 -0.3 0.1 -0.2 -0.6 1.9 0.1 -0.5 -1.0 2.2 -3.1
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.9 -0.3 -0.5 -0.1 -0.4 0.0 -0.4 0.3 -1.3 -0.3 -0.7 -0.8 0.3 -0.3 -0.6 -1.1 0.5 -1.4
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.9 -0.1 -0.7 -0.6 -0.5 0.0 -0.5 -0.1 -0.7 -0.5 -1.4 -0.6 0.8 -0.5 -0.8 0.5 1.2 0.3
Ever had hysterectomy (womb removed) 1.1 1.3 3.6 -0.6 -1.2 -1.2 -1.7 0.0 -1.5 -0.6 -1.9 -1.4 -1.6 -0.7 0.7 -1.3 -1.1 -0.5 0.6 -0.5
Systolic blood pressure, automated reading 0.1 0.3 1.6 -1.3 -0.4 -0.2 -0.4 0.0 -0.3 -0.1 -0.7 -0.2 -0.4 -0.5 -0.5 -0.2 -0.4 0.4 -0.3 0.9
Eye problems/disorders: Diabetes related eye disease 3.3 3.6 7.8 1.9 2.1 2.8 2.2 0.0 2.1 2.5 1.9 2.2 1.9 2.0 -1.2 2.2 2.2 1.4 -1.1 0.1
Angina 2.7 3.5 6.3 -0.8 -2.2 -1.8 -1.6 0.0 -1.9 -1.1 -2.0 -1.8 -2.5 -2.1 2.1 -1.8 -2.3 -1.8 2.4 -1.9
Medication for hormone replacement therapy 0.7 0.8 2.2 -1.4 -0.9 -0.8 -1.2 0.0 -1.0 -0.7 -0.9 -1.0 -1.5 -0.7 -0.2 -1.0 -1.0 -0.0 0.0 0.5
Vitamin and mineral supplements 0.7 0.9 2.6 0.1 -1.1 -1.6 -0.7 0.0 -1.0 -0.9 -0.7 -1.1 -0.4 -0.7 1.5 -1.1 -1.2 -0.6 1.3 -0.6
Supplements: Zinc 0.5 0.6 2.5 0.2 0.7 1.6 1.0 0.0 1.0 0.6 1.0 1.1 0.1 0.3 -0.3 1.1 0.7 0.2 0.1 0.0
Medication: Co-codamol 0.7 0.8 3.0 0.1 -0.9 -0.2 -0.2 0.0 -0.5 -0.8 0.1 -0.4 -0.6 -1.4 1.6 -0.5 -0.9 -1.3 1.7 -0.6
Medication: Metformin 0.1 0.2 0.7 0.8 0.1 0.5 0.0 0.0 0.0 -0.1 0.5 0.0 0.5 -0.4 0.4 0.0 0.1 0.9 0.2 0.9
Diabetes (father) 0.4 0.5 1.9 0.2 0.7 1.4 0.7 0.0 0.7 0.9 0.4 0.7 0.5 0.7 -0.9 0.7 0.8 0.6 -0.8 -0.1
Diabetes (mother) 0.2 0.3 2.3 -0.9 -0.3 -0.2 -0.6 0.0 -0.4 -0.4 0.1 -0.4 -0.4 -0.1 -0.5 -0.4 -0.1 -0.1 -0.4 1.5
Severe depression (siblings) 1.9 2.1 3.7 0.8 1.7 1.1 1.3 0.0 1.6 1.5 1.5 1.5 1.9 1.5 -1.7 1.5 1.7 1.8 -1.7 0.3
Pack years adult smoking proportion 0.2 0.3 1.1 -0.6 0.2 0.1 0.1 0.0 0.2 -0.3 -0.4 0.3 0.0 -0.2 -1.0 0.3 0.2 1.1 -0.8 0.8
Impedance of leg (right) 0.1 0.4 1.8 -1.3 -0.3 -0.5 -0.1 0.0 -0.1 -1.1 0.1 -0.1 -0.2 -0.5 -0.6 -0.1 -0.3 0.2 -0.5 1.4
Leg fat-free mass (left) 0.0 0.2 0.9 0.9 -0.2 -0.3 -0.3 0.0 -0.4 0.2 -0.5 -0.6 0.3 0.3 0.8 -0.5 -0.1 -0.0 0.3 -0.3
Trunk fat percentage 1.3 5.2 9.4 -1.4 -2.7 -2.6 -2.5 0.0 -2.7 -1.6 -2.4 -2.7 -2.8 -3.1 2.3 -2.7 -2.7 -1.4 2.2 -1.0
Hand grip strength (right) 0.1 0.2 1.0 0.6 -0.1 0.3 0.2 0.0 0.0 0.1 -0.2 0.1 -0.1 -0.4 0.7 0.1 -0.2 -0.8 0.9 -1.0
Townsend deprivation index at recruitment 1.5 2.1 5.9 -2.4 -1.3 -1.4 -1.1 0.0 -1.2 -2.3 -2.0 -1.4 -1.7 -1.9 -0.7 -1.3 -1.3 0.9 -0.6 0.4
Current tobacco smoking 0.5 0.7 3.0 0.1 1.0 0.5 0.5 0.0 0.7 0.6 0.3 0.6 0.6 0.8 -1.5 0.6 0.9 1.7 -1.5 0.6
Average weekly fortified wine intake 0.5 0.6 2.1 -0.2 -0.7 -0.4 -0.3 0.0 -0.6 -1.1 -1.3 -0.5 -1.5 -1.3 0.6 -0.4 -0.8 -0.2 0.9 -0.9
Maternal smoking around birth 1.6 2.4 5.0 1.0 1.9 0.9 1.4 0.0 1.4 1.8 1.4 1.4 1.9 2.2 -1.7 1.4 1.7 1.9 -2.0 -0.1
Fed-up feelings 0.2 0.4 1.4 0.3 0.1 1.2 0.6 0.0 0.3 -0.4 0.7 0.4 -1.0 -0.5 0.5 0.4 0.0 -1.0 1.2 0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 2.4 -1.5 -0.9 -1.4 -1.5 0.0 -1.4 -1.3 -0.8 -1.6 -0.7 -0.6 -0.2 -1.5 -0.9 -0.4 -0.6 1.4
Relative age voice broke 0.6 1.0 4.6 1.4 0.5 0.9 1.1 0.0 0.9 1.2 0.5 0.8 0.9 0.5 0.6 0.8 0.5 -1.3 0.6 -2.1
Taking other prescription medications 0.1 0.2 0.6 0.6 0.1 0.5 0.2 0.0 0.1 0.5 0.3 0.2 0.4 -0.1 0.5 0.2 0.1 -0.8 0.6 -0.2
Age when periods started (menarche) 0.2 0.4 1.6 1.3 0.2 0.2 0.3 0.0 0.3 0.8 0.5 0.2 0.7 0.5 1.0 0.2 0.1 -0.2 0.8 -1.1
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 3.4 0.4 -1.3 -0.7 -1.2 0.0 -1.3 -0.4 -1.1 -1.4 -1.2 -1.0 1.9 -1.4 -1.2 -1.3 1.6 -1.4
Heel bone mineral density (BMD) T-score, automated (left) 1.4 3.1 6.3 0.9 2.0 1.0 1.7 0.0 1.8 2.2 1.8 1.7 2.1 2.5 -1.6 1.8 2.0 2.2 -2.1 -0.6
Tinnitus: Yes, but not now, but have in the past 1.3 1.4 4.3 -0.1 -1.3 -1.3 -1.5 0.0 -1.6 -2.1 -0.6 -1.5 -0.9 -1.0 1.6 -1.5 -1.1 -0.1 1.3 0.5
Qualifications: CSEs or equivalent 3.8 5.0 9.9 -1.4 -2.5 -1.7 -2.1 0.0 -2.3 -1.9 -2.4 -2.3 -3.1 -2.8 2.1 -2.3 -2.5 -3.1 2.4 -0.4
Serious illness, injury or assault to yourself 1.7 2.1 3.3 -0.1 -1.6 -1.4 -1.7 0.0 -1.6 -0.9 -1.7 -1.6 -1.8 -1.2 1.6 -1.6 -1.6 -1.7 1.6 -1.0
High blood pressure 0.7 1.9 5.0 1.5 1.3 1.5 1.6 0.0 1.5 2.2 1.7 1.5 0.6 1.5 -0.1 1.5 1.3 0.8 0.2 -1.9
Hayfever, allergic rhinitis or eczema 0.6 1.2 3.0 1.6 1.0 1.7 1.2 0.0 1.3 1.1 1.7 1.3 1.1 1.1 0.3 1.2 1.0 0.2 0.5 0.5
Multivitamins +/- minerals 0.4 0.5 1.9 -1.4 -0.1 0.6 -0.5 0.0 -0.2 -0.6 -0.4 -0.1 -0.7 -0.6 -1.1 -0.1 0.1 -0.7 -0.9 1.3
Stomach or abdominal pain in last month 0.4 0.5 1.9 -0.6 -0.6 -0.6 -1.0 0.0 -0.9 0.1 -0.5 -0.8 -0.5 -0.2 0.1 -0.8 -0.6 -1.1 0.1 1.4
Supplements: Glucosamine 1.8 2.4 4.8 -0.6 -1.8 -1.4 -1.7 0.0 -1.7 -1.5 -1.8 -1.5 -2.2 -1.8 1.6 -1.5 -1.7 -1.1 2.0 0.2
Diverticular disease/diverticulitis (self-reported) 1.6 1.9 5.1 -1.2 -1.6 -1.1 -1.3 0.0 -1.5 -2.2 -0.7 -1.4 -1.8 -1.9 1.4 -1.5 -1.6 -0.2 1.4 0.7
Medication: Atenolol 0.3 0.4 1.6 0.3 -0.4 -0.1 0.2 0.0 -0.2 -0.4 0.6 -0.1 -0.4 -0.7 1.2 -0.1 -0.5 -0.8 1.2 -1.0
Medication: Levothyroxine sodium 0.6 1.1 3.7 -0.2 1.1 0.9 1.1 0.0 1.0 1.3 0.4 1.0 0.9 1.3 -1.7 1.0 1.2 0.4 -1.9 0.2
Sitting height 0.2 1.4 4.6 0.8 1.1 0.0 0.8 0.0 0.8 0.7 0.9 0.6 2.1 1.9 -0.9 0.6 1.1 2.0 -1.7 1.5
Chronic bronchitis/emphysema (father) 2.6 3.0 9.5 0.4 -1.8 -1.2 -0.8 0.0 -1.2 -1.5 -1.3 -1.3 -1.8 -2.4 2.8 -1.4 -1.9 -1.5 3.1 -2.4
High blood pressure (mother) 0.8 1.1 2.2 -0.7 -1.2 -1.3 -1.5 0.0 -1.3 -1.5 -0.5 -1.2 -1.0 -0.7 1.1 -1.3 -1.2 -0.9 1.0 0.5
Body mass index (BMI) 0.7 2.9 4.8 -0.1 -1.8 -1.5 -1.7 0.0 -1.8 -0.5 -1.9 -1.8 -2.2 -1.9 2.2 -1.8 -1.8 -1.7 2.2 -1.9
Impedance of leg (left) 0.1 0.5 1.2 -0.7 0.5 0.1 0.6 0.0 0.6 -0.6 0.9 0.6 0.7 0.2 -1.1 0.5 0.5 1.0 -1.1 1.1
Leg predicted mass (left) 0.0 0.2 0.8 0.9 -0.2 -0.3 -0.3 0.0 -0.4 0.3 -0.5 -0.6 0.3 0.2 0.8 -0.5 -0.1 -0.1 0.3 -0.3
Trunk fat mass 0.8 3.4 5.4 -0.8 -2.1 -2.1 -2.1 0.0 -2.2 -1.1 -2.0 -2.3 -2.0 -2.3 2.0 -2.2 -2.1 -1.2 1.9 -0.9
Waist circumference 0.1 0.5 2.2 1.1 -0.3 -0.2 -0.3 0.0 -0.4 0.9 -0.4 -0.5 -0.3 -0.2 1.3 -0.5 -0.3 -0.7 1.2 -1.5
Number of incorrect matches in round 6.0 10.0 15.6 2.6 3.5 3.0 3.1 0.0 3.4 3.3 3.7 3.5 4.0 3.9 -2.3 3.5 3.6 3.7 -2.4 1.4
Past tobacco smoking 1.9 3.6 8.1 -0.8 -2.1 -1.3 -1.9 0.0 -2.1 -1.9 -0.5 -1.9 -2.4 -1.8 2.5 -2.0 -2.0 -2.8 2.7 0.1
Alcohol usually taken with meals 0.6 0.9 2.3 0.3 1.1 1.1 0.6 0.0 0.7 1.2 1.4 0.9 0.5 1.5 -1.2 0.8 1.2 -0.1 -1.0 1.0
Nervous feelings 0.4 0.7 2.5 1.6 0.6 0.5 1.2 0.0 0.8 0.3 1.2 0.8 0.6 0.7 0.8 0.8 0.6 0.3 1.0 -0.6
Frequency of tenseness / restlessness in last 2 weeks 3.2 5.0 8.4 0.7 2.7 1.9 2.1 0.0 2.4 1.3 2.9 2.4 2.8 2.4 -2.6 2.4 2.7 2.2 -2.7 1.4
Hearing difficulty/problems with background noise 2.0 3.1 9.3 3.0 1.6 1.9 1.9 0.0 1.8 2.2 2.6 1.9 1.4 1.3 0.9 1.9 1.6 0.5 1.1 -1.7
Hair/balding pattern: Pattern 2 0.2 0.3 1.3 -1.1 -0.4 -0.8 -0.6 0.0 -0.4 -0.3 -0.6 -0.6 -0.2 -0.1 -0.4 -0.5 -0.4 -0.4 -0.6 0.5
Had menopause 0.8 1.1 2.3 -1.0 -1.3 -0.8 -1.1 0.0 -1.1 -1.0 -1.1 -0.9 -1.5 -1.5 0.9 -0.9 -1.3 -0.3 1.2 -0.2
Had other major operations 0.1 0.1 0.8 -0.3 0.1 -0.1 0.0 0.0 0.1 0.1 -0.1 0.1 0.5 0.1 -0.4 0.1 0.0 -0.6 -0.4 0.9
Forced vital capacity (FVC) 0.0 0.2 0.6 0.6 0.0 -0.4 -0.2 0.0 -0.4 -0.7 -0.3 -0.6 0.5 0.3 0.3 -0.6 0.0 -0.1 -0.4 -0.1
Heel bone mineral density (BMD) T-score, automated (right) 2.1 4.9 8.2 0.9 2.5 1.6 2.4 0.0 2.4 2.6 1.8 2.3 2.8 2.9 -2.4 2.3 2.5 2.3 -2.8 -0.5
Ever unenthusiastic/disinterested for a whole week 3.2 3.9 7.0 2.2 2.3 2.1 2.2 0.0 2.4 2.7 2.1 2.4 1.8 1.8 -1.1 2.4 2.3 1.9 -0.7 0.3
Qualifications: None of the above 1.5 3.1 10.1 -1.4 -2.0 -1.5 -2.1 0.0 -1.8 -1.2 -2.3 -1.6 -3.2 -2.1 1.3 -1.6 -2.1 -0.7 2.0 -0.3
Financial difficulties in last 2 years 0.1 0.2 1.0 -0.4 0.4 0.2 0.0 0.0 0.1 0.2 0.0 0.1 0.5 -0.2 -0.8 0.2 0.4 0.6 -1.0 0.2
Mouth/teeth dental problems 1.1 1.6 5.1 -2.3 -0.7 -1.3 -1.0 0.0 -1.0 -1.2 -1.6 -1.3 -0.4 -0.8 -1.3 -1.2 -0.6 -1.3 -1.8 1.7
Heart attack 0.7 1.0 2.2 -0.7 -1.2 -1.0 -0.8 0.0 -1.0 -0.8 -1.5 -1.1 -0.6 -1.2 0.7 -1.1 -1.2 -1.4 0.6 -0.6
Allergy 0.2 0.5 1.4 -0.6 -0.7 -0.8 -0.6 0.0 -0.8 -0.7 -0.9 -0.7 -0.9 -0.8 0.4 -0.7 -0.8 0.2 0.3 -1.2
Pain all over the body in last month 1.4 1.5 5.2 0.3 -1.3 -1.1 -0.7 0.0 -1.0 -0.3 -0.6 -0.8 -1.5 -1.1 2.1 -0.9 -1.3 -1.1 2.3 -1.7
Diabetes (self-reported) 0.2 0.3 1.1 0.9 0.3 1.1 0.5 0.0 0.4 0.2 0.6 0.5 0.1 -0.1 0.2 0.5 0.3 0.2 0.6 0.9
Hayfever/allergic rhinitis (self-reported) 1.1 1.5 3.5 1.0 1.3 1.5 1.6 0.0 1.4 0.8 1.9 1.4 1.2 1.3 -0.5 1.4 1.3 1.2 -0.5 0.4
Medication: Ramipril 0.3 0.4 1.6 0.7 -0.2 -0.1 0.1 0.0 -0.1 -0.3 0.4 -0.0 -0.4 -0.4 1.1 -0.1 -0.3 1.3 1.1 -1.0
Medication: Simvastatin 0.1 0.2 0.4 0.1 0.4 0.3 0.6 0.0 0.4 0.6 0.6 0.6 -0.3 0.3 -0.4 0.6 0.4 -0.0 -0.1 -0.2
Fluid intelligence score 0.9 2.0 4.5 2.1 1.7 1.0 1.4 0.0 1.6 1.2 1.4 1.5 1.8 1.9 -0.5 1.5 1.8 0.5 -0.9 -1.0
Illnesses of siblings 0.7 1.0 2.0 0.9 1.2 0.7 1.4 0.0 1.4 0.3 0.8 1.2 1.4 1.2 -0.8 1.2 1.2 0.5 -1.0 -0.4
Neuroticism score 0.2 0.5 2.0 0.2 0.7 1.4 1.1 0.0 0.9 -0.2 0.4 1.0 -0.4 0.1 -0.7 1.0 0.6 -0.0 0.2 0.3
Weight 0.2 0.9 2.2 0.5 -0.9 -1.0 -0.9 0.0 -1.0 -0.0 -1.1 -1.2 -0.8 -0.8 1.5 -1.1 -0.9 -0.6 1.2 -1.0
Impedance of arm (right) 0.1 0.4 1.9 -0.3 0.4 0.3 0.7 0.0 0.6 -0.4 1.0 0.5 1.1 0.1 -0.6 0.4 0.4 1.4 -0.6 0.8
Arm fat percentage (right) 0.9 3.5 6.1 -0.5 -2.1 -1.9 -1.9 0.0 -2.0 -0.9 -1.9 -2.1 -2.1 -2.5 2.2 -2.1 -2.1 -1.4 2.2 -1.7
Trunk fat-free mass 0.1 0.6 2.4 1.5 0.9 0.6 0.6 0.0 0.7 1.0 0.1 0.4 1.2 1.4 -0.1 0.5 0.9 0.3 -0.6 -0.1
Hip circumference 0.2 0.8 3.7 1.3 -0.6 -0.4 -0.5 0.0 -0.7 0.1 -0.3 -0.7 -0.5 -0.7 1.9 -0.7 -0.5 -0.2 1.7 -1.1
Time employed in main current job 0.3 0.4 0.9 -0.7 -0.7 -0.9 -0.7 0.0 -0.8 -0.2 -0.9 -0.9 -0.3 -0.1 0.4 -0.9 -0.6 -0.3 -0.2 -0.7
Alcohol intake versus 10 years previously 0.1 0.1 0.4 0.6 0.1 -0.3 -0.2 0.0 -0.2 0.3 0.3 -0.3 -0.1 0.3 0.4 -0.3 0.1 0.4 -0.1 -0.4
Father’s age at death 1.9 2.6 6.4 2.5 1.7 1.9 1.9 0.0 1.9 2.1 1.3 1.9 1.9 1.5 -0.1 2.0 1.6 0.6 -0.2 -1.3
Worrier / anxious feelings 2.2 4.1 6.9 2.6 2.2 2.2 2.6 0.0 2.4 2.4 2.2 2.5 1.4 2.1 -0.3 2.5 2.2 1.2 0.1 -1.9
Frequency of tiredness / lethargy in last 2 weeks 0.6 0.9 2.2 0.8 0.9 1.0 1.4 0.0 1.1 1.5 1.3 0.9 0.9 0.6 -0.2 0.9 0.9 -0.9 -0.2 -1.3
Falls in the last year 0.3 0.4 1.7 1.3 0.4 0.7 0.4 0.0 0.4 0.3 0.7 0.6 -0.2 0.2 0.6 0.6 0.5 -0.3 0.9 -0.9
Hair/balding pattern: Pattern 3 2.6 3.9 7.1 2.4 2.3 2.7 2.3 0.0 2.2 2.3 2.0 2.4 2.2 1.8 -0.9 2.4 2.3 1.3 -0.9 -1.0
Number of live births 0.8 1.1 4.7 -1.9 -0.2 -1.1 -0.8 0.0 -0.5 -0.8 -0.8 -0.4 -0.6 -0.5 -1.5 -0.4 -0.2 1.4 -1.6 2.2
Forced expiratory volume in 1-second (FEV1) 0.1 0.2 0.6 0.8 -0.0 -0.4 -0.2 0.0 -0.4 -0.3 0.2 -0.5 0.3 0.5 0.8 -0.5 -0.1 -0.5 0.1 -0.7
Pulse rate 0.2 0.3 1.4 -0.2 -0.4 -0.6 -0.6 0.0 -0.6 -1.2 -0.6 -0.7 -0.5 -0.4 0.2 -0.7 -0.4 0.2 -0.2 -0.6
Happiness 5.3 6.5 11.8 2.4 2.9 3.4 3.2 0.0 3.2 2.3 2.6 3.2 2.4 2.3 -1.7 3.2 3.0 2.5 -1.5 -0.4
Noisy workplace 2.9 3.6 7.6 -1.6 -2.1 -2.0 -2.1 0.0 -2.0 -2.3 -2.1 -1.9 -2.0 -2.8 1.1 -1.9 -2.2 -0.8 1.4 2.0
Qualifications: A levels/AS levels or equivalent 0.8 1.8 4.9 2.0 1.4 0.8 1.2 0.0 1.2 1.1 2.2 1.1 2.2 2.1 0.0 1.1 1.6 0.9 -0.7 -0.2
Serious illness, injury or assault of a close relative in last 2 years 1.2 1.4 4.8 0.2 1.2 1.3 1.1 0.0 1.2 0.7 1.2 1.2 0.9 1.2 -1.5 1.2 1.3 2.2 -1.3 1.0
Mouth/teeth dental problems: Dentures 0.4 0.6 2.7 0.0 -0.7 0.2 -0.2 0.0 -0.1 -0.4 -0.8 -0.0 -1.4 -1.2 1.0 -0.0 -0.8 -0.4 1.6 -1.1
Asthma 0.0 0.1 0.3 0.3 0.0 -0.4 -0.2 0.0 -0.1 -0.1 -0.3 -0.0 0.4 -0.1 0.3 0.0 -0.0 -0.5 0.2 -0.1
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.3 2.2 1.3 1.4 1.3 1.5 0.0 1.4 0.9 0.9 1.2 1.4 0.9 -0.7 1.2 1.5 0.0 -1.1 -1.1
Medication: Cholesterol lowering 0.2 0.3 1.0 0.9 0.4 0.8 0.8 0.0 0.5 0.1 1.0 0.6 0.6 0.0 0.4 0.5 0.4 0.1 0.4 -0.2
Depression (self-reported) 3.2 3.8 6.6 1.7 2.3 2.1 2.1 0.0 2.2 1.4 2.3 2.2 2.3 2.6 -1.4 2.2 2.3 2.1 -1.5 0.1
Medication: Lansoprazole 0.3 0.3 1.8 -0.6 -0.1 0.3 -0.1 0.0 0.2 0.0 -1.0 0.1 -0.9 -0.4 -0.4 0.2 -0.2 -1.4 0.0 -1.1
Prospective memory result 0.5 0.6 3.6 -1.9 -0.6 -0.4 -0.5 0.0 -0.6 -0.3 -0.5 -0.6 -0.8 -0.7 -0.8 -0.6 -0.6 0.1 -0.4 1.2
Lung cancer (father) 0.6 0.7 2.6 -1.4 -0.3 -0.2 -0.8 0.0 -0.6 -1.6 -0.5 -0.4 -1.2 -1.0 -0.8 -0.4 -0.3 1.1 -0.4 0.7
Illnesses of mother 0.3 0.4 1.4 -0.2 0.6 0.5 0.6 0.0 0.5 0.8 -0.2 0.6 0.3 0.9 -1.2 0.6 0.6 0.9 -0.9 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 3.2 1.0 1.2 0.7 0.8 0.0 0.8 0.8 1.0 0.7 1.5 1.8 -0.7 0.7 1.2 0.7 -1.2 0.2
Pulse wave Arterial Stiffness index 0.6 0.7 2.6 0.2 0.9 0.7 0.9 0.0 0.9 0.2 1.2 0.8 0.5 0.8 -0.8 0.8 0.9 1.6 -0.6 0.8
Impedance of arm (left) 0.1 0.3 0.8 -0.8 -0.4 -0.4 -0.2 0.0 -0.3 -0.9 0.5 -0.3 0.3 -0.6 0.0 -0.3 -0.4 0.8 -0.1 0.9
Arm fat mass (right) 0.5 2.2 3.4 -0.3 -1.6 -1.6 -1.6 0.0 -1.7 -0.6 -1.7 -1.8 -1.7 -1.9 1.8 -1.8 -1.6 -1.1 1.7 -1.2
Trunk predicted mass 0.1 0.7 2.5 1.6 1.0 0.7 0.7 0.0 0.7 1.1 0.2 0.5 1.3 1.5 -0.2 0.6 1.0 0.3 -0.7 0.0
Standing height 0.2 2.3 6.9 0.9 1.6 0.8 1.3 0.0 1.2 0.7 1.3 1.0 2.6 2.2 -1.4 1.0 1.6 2.2 -2.2 1.8
Length of working week for main job 0.9 1.0 3.0 0.2 1.1 0.8 0.8 0.0 1.0 1.1 0.5 0.8 1.2 1.7 -1.5 0.9 1.2 0.1 -1.5 0.5
Exposure to tobacco smoke at home 1.2 1.4 2.5 1.0 1.4 1.4 1.3 0.0 1.5 0.9 0.7 1.6 1.1 1.0 -0.9 1.6 1.3 1.5 -0.8 -0.7
Breastfed as a baby 0.1 0.1 0.7 -0.3 -0.4 -0.4 0.3 0.0 0.0 0.4 0.1 0.0 -0.1 0.0 0.5 -0.0 -0.3 -0.5 0.4 -0.8
Tense / ‘highly strung’ 0.2 0.3 0.7 -0.4 0.4 0.1 0.4 0.0 0.4 -0.6 0.5 0.4 0.7 0.0 -0.8 0.4 0.4 0.2 -0.7 0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 9.4 14.4 20.5 3.5 4.4 4.3 4.5 0.0 4.5 3.9 3.8 4.5 4.3 3.8 -2.7 4.5 4.4 3.9 -2.7 -0.5
Hair/balding pattern: Pattern 4 0.1 0.1 0.6 -0.7 -0.1 0.1 0.0 0.0 0.1 -0.7 -0.1 0.0 -0.6 -0.8 -0.4 0.0 -0.2 -0.3 0.1 -0.5
Birth weight of first child 1.8 3.2 7.9 2.4 1.7 1.5 2.1 0.0 1.9 2.8 2.2 1.8 2.8 2.3 0.1 1.8 1.7 0.1 -0.2 -0.6
Peak expiratory flow (PEF) 0.4 1.0 2.6 0.6 -0.9 -1.1 -0.9 0.0 -1.1 -0.4 -0.8 -1.4 -0.5 -0.3 1.6 -1.4 -0.9 -1.1 0.9 -1.2
Pulse wave reflection index 1.5 1.9 5.5 1.1 1.4 1.6 1.5 0.0 1.6 1.6 2.3 1.8 0.8 1.6 -0.4 1.7 1.4 1.2 0.1 0.3
Ever highly irritable/argumentative for 2 days 1.9 2.2 6.7 -2.6 -1.1 -1.0 -1.6 0.0 -1.3 -1.7 -1.9 -1.3 -1.6 -2.2 -1.1 -1.2 -1.1 -0.4 -0.7 2.2
Loud music exposure frequency 0.4 0.4 1.4 -0.2 -0.6 -0.7 -0.8 0.0 -0.7 -1.2 0.0 -0.6 -0.5 -0.5 0.7 -0.6 -0.6 0.1 0.7 1.0
Qualifications: O levels/GCSEs or equivalent 1.4 2.2 5.1 1.7 1.7 1.7 1.7 0.0 1.5 0.8 2.3 1.4 1.9 1.9 -0.8 1.4 1.8 1.5 -1.1 0.2
Mouth/teeth dental problems: Bleeding gums 1.8 2.4 4.4 1.5 1.7 1.7 1.6 0.0 1.7 1.4 2.1 1.8 1.8 2.0 -0.8 1.8 1.7 1.7 -0.6 -0.4
Blood clot in the leg (DVT) 1.4 1.8 4.8 -1.7 -1.3 -1.6 -1.6 0.0 -1.5 -1.4 -1.6 -1.7 -0.8 -1.0 -0.3 -1.6 -1.2 0.2 -0.4 2.2
Medication: Paracetamol 1.4 2.3 13.2 -1.4 -1.3 -0.8 -0.9 0.0 -1.2 -0.8 -1.6 -1.2 -2.2 -1.3 0.7 -1.2 -1.4 -3.6 1.1 -1.8
Headache pain in last month 0.4 0.8 2.2 0.9 1.0 0.8 0.7 0.0 0.8 1.5 1.2 0.9 0.9 1.3 -0.6 0.9 1.0 -0.2 -0.4 0.8
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 1.2 -1.0 -0.6 -1.1 -0.8 0.0 -0.7 -0.7 -1.0 -0.8 -0.5 -0.5 -0.3 -0.8 -0.5 -0.1 -0.5 0.6
Glaucoma (self-reported) 0.5 0.6 1.6 0.5 0.9 0.9 0.9 0.0 0.8 1.0 0.6 0.7 1.3 0.7 -0.8 0.8 0.9 0.4 -1.0 -0.6
Gout (self-reported) 0.3 0.4 1.4 -1.1 -0.8 -0.5 -0.8 0.0 -0.6 -0.2 -0.7 -0.6 -0.6 -0.6 -0.1 -0.6 -0.7 0.0 0.1 1.2
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 2.2 0.3 1.3 1.5 1.3 0.0 1.3 1.4 0.8 1.4 0.7 1.3 -1.4 1.5 1.3 0.8 -1.3 0.3
Medication: Amlodipine 0.3 0.4 4.2 -0.4 -0.5 -0.2 0.1 0.0 -0.2 -0.1 -0.6 -0.3 -0.8 -0.8 0.3 -0.3 -0.5 -0.3 0.5 -2.0
Medication: Ventolin 100micrograms inhaler 0.2 0.3 1.0 -0.5 -0.6 -1.0 -0.5 0.0 -0.5 -0.6 -1.0 -0.5 0.1 -0.7 0.2 -0.5 -0.6 -0.7 0.2 0.5
Birth weight 3.8 8.2 13.7 3.5 3.2 3.3 3.5 0.0 3.5 3.7 3.0 3.4 3.3 3.3 -1.0 3.4 3.2 1.1 -1.0 -0.7
Chronic bronchitis/emphysema (mother) 0.3 0.4 1.4 1.2 0.2 -0.6 0.5 0.0 0.4 0.0 0.7 0.4 0.3 0.3 1.1 0.3 0.1 1.0 0.8 -1.0
High blood pressure (siblings) 0.5 0.8 2.3 -0.2 -0.9 0.1 -0.8 0.0 -0.7 0.2 -1.0 -0.6 -1.5 -0.9 0.9 -0.6 -0.8 -1.5 1.4 -0.7
Forced vital capacity (FVC), Best measure 0.2 0.8 2.9 0.4 0.9 0.3 0.5 0.0 0.5 0.1 0.4 0.3 1.6 1.2 -1.1 0.3 0.9 1.2 -1.7 1.0
Body fat percentage 1.2 4.8 8.4 -1.1 -2.5 -2.2 -2.3 0.0 -2.5 -1.3 -2.2 -2.5 -2.7 -2.9 2.4 -2.5 -2.5 -1.6 2.4 -1.3
Leg fat percentage (right) 1.0 3.7 7.1 -0.5 -2.1 -1.8 -1.8 0.0 -1.9 -0.8 -1.8 -1.8 -2.7 -2.5 2.5 -1.9 -2.1 -1.7 2.6 -1.8
Arm fat-free mass (right) 0.0 0.1 0.6 0.8 0.2 0.0 -0.1 0.0 -0.1 0.4 -0.4 -0.2 0.3 0.6 0.1 -0.2 0.3 0.1 -0.2 0.1
Exposure to tobacco smoke outside home 1.3 1.7 4.3 -0.0 -1.4 -1.3 -1.3 0.0 -1.3 -1.7 -1.2 -1.1 -1.7 -1.6 1.8 -1.2 -1.5 -0.5 2.1 -0.1
Comparative body size at age 10 0.3 0.8 3.7 1.1 1.0 0.7 0.9 0.0 0.8 1.0 0.6 0.8 0.8 0.4 -0.5 0.8 1.0 1.1 -0.5 -1.9
Number of full brothers 0.5 0.6 1.4 -0.8 -0.8 -1.2 -1.2 0.0 -0.9 -0.1 -1.1 -0.9 -0.6 -0.5 -0.0 -0.9 -0.8 -0.3 0.1 1.1
Worry too long after embarrassment 1.1 1.8 8.6 2.9 0.7 1.0 1.2 0.0 1.0 0.8 1.5 1.1 0.1 1.2 1.8 1.0 0.7 -0.1 2.2 -2.0
Seen a psychiatrist for nerves, anxiety, tension or depression 13.1 17.0 24.7 2.9 4.9 4.2 4.7 0.0 4.9 4.0 3.9 4.8 4.8 4.5 -3.9 4.9 5.0 3.9 -3.9 -0.2
Wheeze or whistling in the chest in last year 1.1 1.9 4.4 2.0 1.5 1.7 1.3 0.0 1.5 2.1 0.6 1.6 0.9 1.6 -0.2 1.6 1.4 1.3 0.2 -1.5
Number of children fathered 0.2 0.2 0.9 0.1 -0.0 0.8 0.2 0.0 0.2 0.8 -0.4 0.3 -0.4 -0.3 0.0 0.3 -0.1 -0.9 0.6 -0.6
Reason for reducing amount of alcohol drunk: Health precaution 6.8 8.0 16.4 1.7 3.4 2.3 2.9 0.0 3.2 2.4 2.9 3.2 3.0 3.1 -2.8 3.2 3.3 4.0 -2.9 0.8
Age at first live birth 0.4 0.7 1.6 0.7 0.7 1.2 1.3 0.0 1.0 0.4 1.2 0.9 1.0 0.6 -0.1 0.8 0.8 -1.1 -0.1 -0.6
Pulse wave peak to peak time 0.5 0.5 2.0 -0.2 -0.8 -0.7 -0.9 0.0 -0.8 -0.3 -1.1 -0.8 -0.3 -0.7 0.6 -0.8 -0.8 -1.4 0.4 -0.6
Health satisfaction 5.2 6.7 9.6 1.8 3.1 2.7 2.9 0.0 3.0 2.7 2.4 2.9 2.8 2.8 -2.5 2.9 3.1 2.9 -2.6 -0.3
Shortness of breath walking on level ground 0.4 0.5 1.3 -0.2 -0.8 -0.1 -0.7 0.0 -0.8 0.2 -1.2 -0.8 -1.0 -0.5 0.5 -0.7 -0.8 -0.9 0.6 0.1
Qualifications: College or University degree 1.7 5.4 12.8 0.4 2.5 1.4 1.8 0.0 2.2 1.6 2.6 2.1 3.6 2.4 -2.9 2.1 2.7 1.9 -3.6 2.6
Eye problems/disorders: None of the above 0.2 0.2 1.7 -0.3 -0.2 -0.3 0.3 0.0 -0.0 -0.8 -0.4 -0.1 -0.8 -0.4 0.2 -0.1 -0.3 -0.5 0.3 -1.3
Mouth/teeth dental problems: Loose teeth 0.4 0.5 2.2 1.0 0.7 0.4 0.3 0.0 0.6 0.8 -0.3 0.6 0.8 0.4 -0.6 0.7 0.8 1.5 -0.6 0.9
Emphysema/chronic bronchitis 0.3 0.4 2.4 -0.9 -0.2 -1.0 -0.6 0.0 -0.3 -0.7 -0.0 -0.4 -0.4 -0.1 -0.5 -0.4 -0.1 0.4 -0.5 1.6
Medication for pain relief, constipation, heartburn 0.7 1.2 5.3 0.2 0.9 0.6 0.6 0.0 0.8 0.9 0.5 0.9 1.2 1.6 -1.3 0.9 1.0 2.3 -1.3 1.1
Neck or shoulder pain in last month 0.4 0.6 1.3 1.0 0.9 0.4 0.5 0.0 0.7 0.8 1.0 0.8 1.1 0.6 -0.2 0.8 0.9 1.2 -0.3 -0.2
Medication: Blood pressure 0.3 0.5 1.0 0.8 0.4 1.0 0.8 0.0 0.7 1.0 0.7 0.8 0.1 0.4 0.2 0.8 0.4 -0.4 0.7 -1.0
Angina (self-reported) 2.9 3.8 6.6 -0.7 -2.3 -1.9 -1.8 0.0 -2.0 -1.1 -2.0 -1.9 -2.5 -2.1 2.3 -1.9 -2.4 -1.8 2.6 -1.9
Migraine (self-reported) 0.2 0.2 1.0 -0.4 0.1 -0.0 -0.5 0.0 -0.3 -0.2 -0.7 -0.2 -0.5 0.3 -0.9 -0.1 0.1 -0.6 -0.7 1.0
Medication: Ibuprofen 0.7 0.8 1.7 1.1 1.0 1.0 1.3 0.0 1.2 0.7 0.9 1.0 1.1 0.6 -0.3 1.0 1.1 0.1 -0.6 -1.1
Medication: Allopurinol 0.4 0.5 0.9 -0.6 -0.9 -1.0 -0.7 0.0 -0.6 -0.7 -0.6 -0.6 -0.8 -0.8 0.8 -0.7 -0.9 -0.3 0.8 0.5
Medication: Omeprazole 2.2 2.6 4.9 -1.0 -1.9 -2.0 -1.7 0.0 -1.9 -1.5 -1.3 -1.7 -1.7 -2.2 1.8 -1.7 -2.1 -1.2 1.8 -0.1
Medication: Seretide 50 evohaler 0.5 0.6 2.3 -1.5 -0.6 -1.0 -0.7 0.0 -0.6 -1.1 -0.9 -0.7 -0.2 -0.8 -0.5 -0.6 -0.7 -0.8 -0.6 0.4
Mean time to correctly identify matches 0.2 0.3 1.8 -0.9 0.2 0.5 0.2 0.0 0.2 -0.2 0.1 0.2 0.1 0.3 -1.0 0.2 0.3 0.9 -0.7 1.3
Heart disease (mother) 0.2 0.2 1.0 -0.1 0.4 0.3 0.6 0.0 0.5 0.2 0.2 0.3 0.4 0.3 -0.7 0.3 0.4 0.0 -1.0 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.8 1.0 0.1 0.8 0.5 0.0 0.3 0.6 0.4 0.4 -0.8 0.3 0.8 0.4 0.0 -0.8 1.3 -1.3
Whole body fat mass 0.7 2.7 4.3 -0.5 -1.9 -1.7 -1.8 0.0 -1.9 -0.7 -1.7 -1.9 -2.0 -2.1 2.0 -1.9 -1.8 -1.4 1.9 -1.1
Leg fat mass (right) 0.7 2.6 4.4 -0.3 -1.8 -1.5 -1.6 0.0 -1.7 -0.7 -1.8 -1.7 -2.1 -1.9 2.0 -1.7 -1.7 -1.4 2.0 -1.2
Arm predicted mass (right) 0.0 0.2 0.9 1.0 -0.0 -0.1 -0.2 0.0 -0.2 0.5 -0.6 -0.4 0.0 0.4 0.6 -0.3 0.0 -0.4 0.2 -0.5
Pulse rate, automated reading 1.2 3.9 7.6 -2.2 -2.2 -2.1 -2.1 0.0 -2.2 -2.8 -2.5 -2.4 -2.3 -2.4 0.7 -2.4 -2.1 -1.1 0.5 -0.5
Alcohol intake frequency. 0.5 1.2 4.5 2.1 0.7 0.7 0.8 0.0 0.7 2.0 1.2 0.7 0.5 0.7 1.1 0.7 0.6 0.7 1.0 -1.7
Comparative height size at age 10 0.1 0.3 2.4 -0.6 -0.1 -0.3 -0.2 0.0 -0.2 -0.4 -0.5 -0.2 0.2 0.1 -0.5 -0.2 -0.0 1.0 -0.6 1.6
Number of full sisters 2.9 3.5 5.6 -1.5 -2.2 -2.2 -2.0 0.0 -2.2 -1.0 -2.3 -2.2 -2.4 -1.8 1.4 -2.2 -2.3 -1.8 1.4 -0.7
Suffer from ‘nerves’ 0.7 1.1 4.4 0.5 1.1 0.4 1.1 0.0 1.1 0.5 1.2 1.1 1.5 0.9 -0.8 1.1 1.1 2.1 -0.9 0.5
Overall health rating 1.0 2.2 4.4 1.0 1.7 0.9 1.6 0.0 1.6 1.6 0.8 1.5 1.8 1.5 -1.5 1.5 1.7 2.1 -1.7 -1.2
Chest pain or discomfort 1.9 2.8 7.5 -0.9 -1.9 -2.0 -1.6 0.0 -1.7 -1.0 -1.4 -1.8 -1.2 -2.0 2.0 -1.8 -1.9 -2.7 1.7 -0.7
Had major operations 0.5 0.6 1.7 -1.3 -0.6 -0.8 -1.1 0.0 -0.8 -0.3 -1.3 -0.7 -0.8 -0.5 -0.7 -0.7 -0.5 -0.1 -0.5 1.1
Age at last live birth 2.3 3.3 7.6 1.6 2.0 1.6 2.0 0.0 2.0 0.7 2.7 1.9 2.8 1.8 -1.1 1.9 2.2 2.1 -1.4 0.8
Family relationship satisfaction 9.1 11.2 15.9 3.3 4.0 3.1 4.0 0.0 3.9 3.3 3.7 3.8 3.7 3.8 -2.2 3.8 4.0 3.8 -2.5 -0.8
Leg pain on walking 1.0 1.3 2.5 -0.5 -1.3 -1.0 -1.2 0.0 -1.3 -0.4 -1.6 -1.3 -1.6 -1.1 1.1 -1.2 -1.3 -1.4 1.2 -0.5
Qualifications: NVQ or HND or HNC or equivalent 4.2 5.1 8.8 -2.2 -2.7 -2.2 -2.3 0.0 -2.4 -2.2 -2.9 -2.5 -2.4 -3.0 1.4 -2.5 -2.8 -2.5 1.7 0.4
Commuting to job workplace: Car/motor vehicle 0.3 0.4 1.6 0.9 0.7 1.2 0.4 0.0 0.6 0.9 0.9 0.6 0.0 0.4 0.1 0.6 0.6 0.4 0.1 -0.7
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 1.2 1.1 0.3 0.4 0.6 0.0 0.4 0.7 0.6 0.4 0.3 0.6 0.7 0.4 0.2 -1.0 0.7 -1.1
Medication: Aspirin 0.7 1.0 2.2 -0.2 -1.2 -0.9 -1.1 0.0 -1.1 -0.7 -0.3 -1.1 -0.8 -1.2 1.5 -1.2 -1.2 -0.9 1.3 0.3
Supplements: Vitamin C 0.1 0.1 1.3 0.3 0.2 0.3 0.4 0.0 0.2 -0.2 0.1 0.2 0.0 0.0 0.1 0.2 0.2 1.1 -0.1 -0.1
Knee pain experienced in last month 0.6 0.9 5.4 0.0 -0.9 0.0 -0.7 0.0 -0.8 -0.3 -0.8 -0.7 -1.3 -0.8 1.2 -0.7 -0.8 -2.3 1.4 -0.7
Hypertension (Self-reported) 0.4 1.2 4.0 1.3 0.8 1.2 1.1 0.0 1.0 2.0 1.4 1.1 0.1 1.1 0.5 1.0 0.8 0.1 0.7 -2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 3.8 0.2 -0.6 -0.0 -0.2 0.0 -0.2 -0.6 -0.2 -0.2 -0.5 -0.7 1.1 -0.3 -0.7 -1.9 1.4 -0.5
Illnesses of father: Heart disease 1.4 1.9 6.6 -0.6 -1.7 -0.7 -1.3 0.0 -1.4 -0.6 -1.4 -1.5 -1.2 -1.2 1.7 -1.5 -1.7 -2.6 1.8 -0.2
Illnesses of siblings: Diabetes 1.0 1.2 3.0 -0.5 -1.3 -1.4 -1.7 0.0 -1.5 -0.6 -1.1 -1.5 -0.7 -0.9 1.0 -1.5 -1.2 -0.6 0.6 0.5
Smoking status: Previous 1.6 2.4 4.7 1.1 1.8 1.0 1.7 0.0 1.8 1.7 0.7 1.6 2.1 1.5 -1.6 1.6 1.7 2.2 -1.8 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 4.9 1.1 1.4 1.0 1.6 0.0 1.4 0.9 1.5 1.2 2.2 1.9 -0.8 1.2 1.4 1.0 -1.3 -0.4
Whole body fat-free mass 0.1 0.3 2.0 1.4 0.6 0.3 0.4 0.0 0.3 0.8 -0.1 0.1 0.9 1.0 0.2 0.2 0.6 0.2 -0.2 -0.3
Leg fat-free mass (right) 0.0 0.2 1.6 1.2 0.3 0.0 0.1 0.0 0.0 0.6 -0.1 -0.2 0.9 0.8 0.4 -0.1 0.4 0.3 -0.0 -0.4
Arm fat percentage (left) 1.1 4.4 7.7 -0.7 -2.4 -2.1 -2.2 0.0 -2.3 -1.1 -2.0 -2.4 -2.5 -2.8 2.5 -2.4 -2.3 -1.7 2.5 -1.6
Average weekly red wine intake 2.1 3.2 5.7 1.2 2.1 1.4 1.5 0.0 1.7 1.6 1.7 1.7 2.4 2.2 -2.1 1.7 2.3 1.6 -2.3 1.1
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.4 0.4 0.1 0.2 0.4 0.0 0.2 -0.2 0.0 0.1 0.6 -0.0 0.3 0.1 0.1 0.3 0.1 -0.5
Mood swings 0.2 0.3 1.4 0.0 -0.2 0.6 0.3 0.0 0.0 -1.2 0.2 0.1 -0.7 -1.0 0.4 0.0 -0.2 -0.9 0.9 0.2
Loneliness, isolation 0.2 0.3 1.7 -0.3 0.4 0.5 0.4 0.0 0.4 0.4 0.2 0.4 -0.1 0.1 -1.0 0.4 0.5 1.0 -0.7 1.3
Long-standing illness, disability or infirmity 0.1 0.2 0.8 -0.5 -0.3 -0.6 -0.4 0.0 -0.3 0.0 -0.9 -0.4 0.0 -0.8 -0.1 -0.3 -0.4 -0.2 -0.2 -0.7
Ever had bowel cancer screening 0.3 0.3 1.6 0.3 -0.4 -0.3 -0.2 0.0 -0.3 0.2 -0.2 -0.4 -0.4 -0.1 1.0 -0.4 -0.4 -1.3 0.9 -0.7
Diabetes diagnosed by doctor 0.5 0.8 2.2 1.4 0.9 1.5 0.8 0.0 0.8 0.6 1.3 0.9 1.0 0.4 -0.2 0.8 0.9 0.8 -0.1 1.2
Ever had stillbirth, spontaneous miscarriage or termination 1.7 1.8 3.5 0.7 1.6 1.6 1.5 0.0 1.5 0.8 1.1 1.4 1.9 1.3 -1.6 1.4 1.6 0.7 -1.8 0.1
Friendships satisfaction 0.8 1.0 3.5 0.7 1.0 1.1 1.4 0.0 1.2 0.3 1.0 1.1 0.7 0.9 -0.6 1.1 1.1 1.9 -0.6 -0.5
Qualifications: nursing, teaching 1.2 1.8 11.4 1.1 -1.0 -0.4 -0.0 0.0 -0.7 0.3 -1.1 -0.9 -0.7 -1.0 2.2 -0.9 -1.0 -1.5 2.0 -3.4
Commuting to job workplace: Walk 0.3 0.4 1.7 0.4 -0.5 -0.7 -0.2 0.0 -0.2 0.3 -0.9 -0.3 -0.1 0.1 0.8 -0.2 -0.6 -1.3 0.8 -1.0
Eye problems/disorders: Cataract 0.4 0.5 1.1 0.8 0.7 0.6 0.4 0.0 0.6 1.0 0.7 0.6 0.9 0.9 -0.4 0.6 0.8 0.7 -0.4 1.1
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 4.5 2.1 0.4 0.6 0.3 0.0 0.3 1.3 1.0 0.4 0.7 0.9 1.3 0.3 0.4 0.7 1.1 -2.0
Medication for cholesterol 0.3 0.5 2.0 0.6 0.8 0.4 0.7 0.0 0.7 -0.1 0.1 0.6 1.4 0.4 -0.7 0.7 0.8 0.3 -0.9 1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.6 1.8 4.0 1.6 1.6 1.8 1.7 0.0 1.6 1.4 2.0 1.6 0.9 1.2 -0.4 1.6 1.6 1.0 -0.4 -0.5
Back pain experienced in last month 0.2 0.4 1.3 0.5 0.7 0.0 0.6 0.0 0.6 0.2 0.8 0.8 0.7 0.4 -0.2 0.8 0.6 0.5 -0.2 1.1
Mineral and other dietary supplements 0.1 0.2 0.6 0.7 0.3 -0.3 0.3 0.0 0.2 0.1 0.7 0.0 0.8 0.8 0.0 -0.0 0.3 0.5 -0.2 0.6
Breast cancer (self-reported) 0.6 0.7 1.6 0.3 -0.8 -1.1 -1.3 0.0 -1.0 -0.6 -0.5 -1.0 -0.9 -0.3 1.3 -1.0 -0.8 -0.6 1.1 0.1
Asthma (self-reported) 0.1 0.1 0.4 0.4 -0.1 -0.6 -0.3 0.0 -0.3 -0.2 -0.1 -0.2 0.3 -0.2 0.6 -0.2 -0.1 -0.7 0.5 -0.0
Osteoporosis (self-reported) 0.1 0.1 1.1 -0.2 -0.2 -0.3 -0.0 0.0 -0.2 -0.1 -0.6 -0.2 -0.1 -0.0 0.1 -0.2 -0.3 -0.4 0.0 -1.1
Osteoarthritis (self-reported) 0.3 0.4 1.6 0.6 0.4 0.6 0.5 0.0 0.6 0.9 -0.7 0.6 -0.3 -0.0 -0.2 0.7 0.4 -0.6 0.2 -1.3
Medication: Aspirin 0.4 0.6 1.0 -0.6 -0.9 -0.8 -1.0 0.0 -0.9 -0.8 -0.2 -0.9 -0.6 -0.9 0.7 -1.0 -0.9 -0.2 0.5 1.0
Medication: Gliclazide 0.7 0.8 2.0 -0.7 -1.0 -0.3 -0.7 0.0 -0.8 -1.2 -0.5 -0.8 -1.4 -1.4 0.7 -0.8 -1.0 -0.4 1.1 0.8
Illnesses of father: None of the above (group 1) 0.5 0.6 2.3 -1.1 -0.5 -0.9 -1.1 0.0 -0.8 -1.0 -0.1 -0.6 -1.1 -0.5 -0.3 -0.7 -0.4 0.4 -0.1 1.5
Smoking status: Current 0.6 1.0 3.5 0.2 1.1 0.6 0.6 0.0 0.8 0.9 0.4 0.7 0.9 1.1 -1.6 0.8 1.1 1.9 -1.7 0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.1 0.4 0.5 -0.2 -0.6 -0.4 0.0 -0.4 0.4 -0.3 -0.4 0.3 0.3 0.6 -0.4 -0.1 -0.5 0.1 -0.4
Whole body water mass 0.1 0.4 2.0 1.4 0.6 0.4 0.4 0.0 0.4 0.9 -0.1 0.2 0.9 1.0 0.1 0.2 0.6 0.2 -0.3 -0.2
Leg predicted mass (right) 0.1 0.3 1.9 1.4 0.3 0.0 0.1 0.0 -0.0 0.6 -0.1 -0.2 0.8 0.7 0.6 -0.2 0.3 0.3 0.2 -0.6
Arm fat mass (left) 0.5 2.2 3.7 -0.1 -1.6 -1.5 -1.6 0.0 -1.7 -0.4 -1.7 -1.7 -1.7 -1.8 1.9 -1.7 -1.6 -1.2 1.9 -1.3
Number of self-reported non-cancer illnesses 0.1 0.1 0.8 0.5 0.2 -0.1 -0.1 0.0 0.0 0.9 -0.2 0.2 -0.1 0.2 0.1 0.2 0.2 -0.1 0.3 -0.7
Average weekly champagne plus white wine intake 0.2 0.3 0.8 -0.2 -0.5 -0.3 -0.5 0.0 -0.5 -0.8 -0.1 -0.6 -0.3 -0.3 0.9 -0.6 -0.5 -0.6 0.6 -0.7
Miserableness 1.6 2.7 7.8 1.7 1.9 2.8 2.1 0.0 2.1 1.3 1.7 2.2 1.2 1.5 -0.9 2.2 1.9 0.6 -0.3 -0.3
Guilty feelings 0.5 0.8 1.6 1.2 1.0 1.1 1.3 0.0 1.0 0.8 0.8 1.0 0.3 0.6 -0.4 1.0 1.1 1.0 -0.3 -0.9
Wears glasses or contact lenses 0.9 1.0 2.1 -0.3 -1.2 -0.9 -1.2 0.0 -1.1 -0.3 -0.9 -0.9 -1.1 -1.1 1.3 -1.0 -1.2 -1.5 1.4 0.4
Ever taken oral contraceptive pill 0.8 0.9 4.1 -0.9 0.8 0.1 0.6 0.0 0.7 0.2 0.3 0.6 1.0 0.7 -1.9 0.6 0.8 0.8 -2.0 1.1
Hearing aid user 0.9 1.0 5.0 0.7 -0.8 -0.0 -0.1 0.0 -0.4 -0.0 -0.1 -0.5 -1.1 -0.8 1.8 -0.5 -0.7 -1.3 1.9 -2.2
Mother’s age at death 0.3 0.4 1.9 0.0 -0.5 0.2 -0.9 0.0 -0.6 -0.9 -0.7 -0.4 -0.6 -0.4 0.6 -0.4 -0.5 -0.5 0.6 1.4
Financial situation satisfaction 1.5 1.9 3.0 0.5 1.5 1.7 1.6 0.0 1.5 1.0 1.4 1.5 1.4 1.0 -1.5 1.5 1.5 1.6 -1.4 1.4
Tinnitus: Yes, now most or all of the time 0.2 0.2 1.3 0.5 -0.0 0.5 0.3 0.0 0.2 -0.1 0.0 0.3 -0.9 -0.5 0.6 0.3 -0.1 -0.2 1.1 -0.5
Commuting to job workplace: Public transport 0.4 0.4 1.6 0.4 0.8 0.2 0.7 0.0 0.6 -0.2 1.3 0.7 0.9 0.6 -0.6 0.7 0.9 0.4 -0.6 0.4
Eye problems/disorders: Glaucoma 0.7 0.8 2.9 0.4 0.9 1.0 0.8 0.0 0.8 1.7 0.0 0.7 1.2 1.0 -1.1 0.8 0.9 0.3 -1.3 -0.6
Medication: Blood pressure 0.3 0.6 4.4 0.6 0.4 0.8 0.8 0.0 0.6 1.1 1.0 0.6 0.0 0.7 0.4 0.5 0.3 0.1 0.4 -2.1
Pain type(s) experienced in last month: Hip pain 1.4 1.7 3.3 -0.8 -1.4 -1.1 -1.3 0.0 -1.5 -1.1 -1.4 -1.4 -1.5 -1.8 1.1 -1.4 -1.5 -1.7 1.1 -1.1
Supplements: Fish oil (including cod liver oil) 0.4 0.5 2.2 -0.7 -0.7 -0.3 -0.6 0.0 -0.5 -0.5 -1.0 -0.4 -1.2 -0.9 0.4 -0.4 -0.7 -1.5 0.6 -0.9
High cholesterol (Self-reported) 0.1 0.1 0.7 0.3 0.2 0.1 0.1 0.0 0.2 0.4 0.8 0.3 0.3 -0.1 0.3 0.2 0.1 -0.3 0.2 -0.3
Medication: Bendroflumethiazide 0.5 0.8 2.8 0.9 0.6 1.7 1.0 0.0 0.9 1.4 0.9 0.9 -0.1 0.6 0.2 0.9 0.7 -0.7 0.6 -1.5
Medication: Paracetamol 0.9 1.4 9.9 -0.8 -0.8 -0.4 -0.4 0.0 -0.5 -0.0 -1.4 -0.5 -1.5 -1.0 0.5 -0.5 -1.0 -3.1 1.0 -2.0
Medication: Lisinopril 3.8 4.9 7.3 1.3 2.6 2.2 2.6 0.0 2.7 2.6 2.7 2.7 2.5 2.4 -2.1 2.6 2.5 1.7 -1.8 -0.0
Medication: Atorvastatin 1.9 2.3 4.1 -1.1 -1.8 -1.5 -1.8 0.0 -1.7 -1.5 -1.2 -1.7 -1.5 -2.0 1.6 -1.7 -2.0 -1.2 1.6 0.4
Illnesses of father: High blood pressure 0.9 1.1 2.2 0.9 1.1 1.1 1.3 0.0 1.3 1.5 0.4 1.2 1.1 0.8 -0.8 1.2 1.1 -0.3 -0.8 -1.4
Alcohol drinker status: Never 0.5 0.6 2.8 0.6 -0.7 -0.4 -0.8 0.0 -0.7 -0.2 -0.2 -0.5 -0.9 -0.2 1.6 -0.6 -0.8 0.1 1.7 0.1
Ever smoked 3.0 5.3 11.6 0.6 2.6 1.6 2.1 0.0 2.5 1.8 0.9 2.4 2.6 2.2 -3.3 2.5 2.5 3.4 -3.4 1.0
Basal metabolic rate 0.0 0.2 1.3 1.1 0.3 0.0 0.1 0.0 0.0 0.6 -0.4 -0.2 0.5 0.6 0.4 -0.1 0.3 0.1 -0.1 -0.3
Leg fat percentage (left) 0.5 1.7 4.3 0.1 -1.3 -1.1 -1.0 0.0 -1.2 -0.2 -0.9 -1.1 -1.7 -1.7 2.0 -1.1 -1.2 -0.9 2.1 -2.0
Arm fat-free mass (left) 0.0 0.2 1.1 1.1 0.4 0.2 0.2 0.0 0.2 0.9 -0.4 0.0 0.5 0.7 0.1 0.1 0.4 0.0 -0.2 -0.4
Number of operations (self-reported) 1.0 1.4 3.7 -1.9 -1.2 -1.3 -1.4 0.0 -1.4 -0.8 -1.4 -1.4 -1.0 -1.3 -0.1 -1.3 -1.2 -1.1 -0.2 1.4
Average weekly beer plus cider intake 0.3 0.4 2.1 0.8 -0.5 -0.2 -0.2 0.0 -0.4 -0.4 0.2 -0.4 -0.3 -0.6 1.4 -0.4 -0.6 -0.0 1.5 -0.9
Irritability 0.4 0.6 2.9 -1.1 -0.3 0.7 -0.4 0.0 -0.4 -1.3 -0.6 -0.2 -1.7 -0.8 -0.6 -0.2 -0.3 -0.8 0.2 1.2
Risk taking 2.1 3.1 6.5 -2.5 -1.6 -2.0 -2.4 0.0 -2.0 -1.8 -2.4 -2.0 -1.3 -1.8 -0.6 -1.9 -1.6 -0.3 -0.7 2.4
Ever had prostate specific antigen (PSA) test 0.2 0.3 1.2 0.7 0.0 -0.1 0.3 0.0 0.4 0.1 0.5 0.4 0.1 0.2 0.9 0.4 0.1 0.4 1.0 -1.1
Fractured/broken bones in last 5 years 0.2 0.3 0.7 0.3 0.6 0.8 0.7 0.0 0.7 0.2 0.3 0.7 0.1 0.4 -0.6 0.7 0.5 -0.4 -0.3 -0.5
Age started oral contraceptive pill 0.2 0.3 1.2 0.3 -0.5 -0.2 -0.1 0.0 -0.4 -0.3 -0.3 -0.3 -0.7 -0.4 1.1 -0.3 -0.5 -0.4 1.1 -0.7
Diastolic blood pressure, automated reading 0.1 0.2 0.7 -0.7 -0.2 0.2 -0.2 0.0 -0.1 -0.5 -0.8 0.0 -0.8 -0.5 -0.4 0.1 -0.2 0.4 0.2 0.5
Ever depressed for a whole week 2.6 3.2 6.7 1.9 2.0 1.9 2.0 0.0 2.2 2.6 1.7 2.1 2.0 1.9 -1.0 2.2 2.0 1.5 -0.8 0.1
Unable to work because of sickness or disability 0.1 0.1 0.4 -0.0 -0.3 -0.3 -0.4 0.0 -0.4 -0.1 -0.1 -0.4 -0.6 -0.2 0.4 -0.4 -0.3 -0.5 0.5 -0.2
Commuting to job workplace: Cycle 0.2 0.2 1.1 -0.7 -0.3 -0.2 0.1 0.0 0.1 -0.4 -0.6 0.1 -1.0 -0.5 -0.3 0.1 -0.4 -0.7 0.3 0.2
Myopia 0.4 0.6 1.5 0.5 0.9 0.4 0.5 0.0 0.5 0.4 0.4 0.5 0.8 1.2 -0.9 0.6 0.9 1.2 -1.1 0.8
Vascular/heart problems diagnosed by doctor 0.3 0.9 3.9 -1.0 -0.7 -0.9 -1.1 0.0 -0.9 -1.5 -1.1 -0.9 -0.1 -0.8 -0.3 -0.9 -0.7 -0.3 -0.5 2.0
Cholesterol lowering medication 0.1 0.2 0.9 -0.7 -0.1 -0.5 -0.6 0.0 -0.3 0.3 -0.1 -0.3 -0.5 -0.0 -0.4 -0.3 -0.1 0.9 -0.5 0.7
Medication: Omeprazole (e.g. Zanprol) 2.0 2.4 4.6 -0.9 -1.7 -1.8 -1.6 0.0 -1.8 -1.4 -1.3 -1.6 -1.9 -2.1 1.6 -1.6 -1.9 -1.4 1.7 -0.1
Pain experienced in last month 0.3 0.5 1.8 -1.3 -0.4 -0.5 -0.5 0.0 -0.5 -0.8 -0.7 -0.6 -0.1 -0.4 -0.9 -0.6 -0.3 1.0 -1.1 0.8
Supplements: Calcium 1.5 1.7 3.9 -1.3 -1.3 -0.8 -1.7 0.0 -1.4 -1.3 -1.4 -1.2 -2.0 -1.5 0.8 -1.2 -1.4 -1.6 1.0 -1.0
Basal cell carcinoma (self-reported) 3.9 4.6 6.9 -1.3 -2.5 -2.1 -2.6 0.0 -2.6 -1.8 -2.3 -2.6 -2.3 -2.5 2.0 -2.6 -2.5 -2.5 1.9 -0.1
Heart attack/myocardial infarction (self-reported) 0.9 1.2 2.5 -0.7 -1.3 -1.2 -1.0 0.0 -1.2 -1.1 -1.6 -1.3 -0.8 -1.3 0.9 -1.3 -1.4 -1.3 0.8 -0.5
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 4.1 -1.4 -1.0 -1.5 -1.4 0.0 -1.3 -1.1 -1.2 -1.4 -0.6 -0.7 -0.3 -1.4 -0.9 0.5 -0.4 2.0
Heart disease (siblings) 3.0 3.7 6.8 -1.0 -2.3 -2.1 -2.1 0.0 -2.2 -1.4 -1.9 -2.0 -2.3 -2.6 2.1 -2.0 -2.4 -1.2 2.3 -0.7
Alcohol drinker status: Previous 0.7 0.8 2.2 0.8 -0.8 -1.0 -0.8 0.0 -0.8 0.2 -0.9 -0.9 -0.4 -0.6 1.5 -0.9 -0.8 -1.2 1.2 -1.5
Pack years of smoking 0.3 0.5 1.2 -1.0 -0.5 -0.7 -0.7 0.0 -0.6 -0.9 -0.8 -0.4 -0.7 -0.9 -0.4 -0.4 -0.5 0.7 -0.2 1.1
Impedance of whole body 0.1 0.5 1.7 -1.3 -0.5 -0.8 -0.3 0.0 -0.4 -1.3 0.3 -0.4 0.0 -0.7 -0.2 -0.5 -0.5 0.7 -0.3 1.2
Leg fat mass (left) 0.3 1.3 2.4 0.0 -1.2 -1.1 -1.1 0.0 -1.2 -0.3 -1.2 -1.2 -1.4 -1.4 1.5 -1.2 -1.1 -0.9 1.5 -1.2
Arm predicted mass (left) 0.0 0.2 0.9 1.0 0.5 0.2 0.3 0.0 0.3 0.7 -0.3 0.0 0.6 0.7 -0.1 0.1 0.5 0.1 -0.5 -0.2