TWAS hub - ACVRL1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0266	0.012	0.0017	0.000	0.010	-0.001	NA	0.000	0.41	2.5e-03	0.6500	NA	0.25
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0898	0.038	0.0013	-0.001	0.034	0.017	NA	0.003	0.40	9.4e-05	0.0045	NA	0.15

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Number of full brothers	7.2	9.0	13.0	2.2	3.6
Pulse rate	6.4	10.8	16.5	4.1	2.2
Supplements: Fish oil (including cod liver oil)	5.9	7.7	11.2	3.3	2.0
Medication: Ibuprofen	5.0	6.0	10.9	3.3	1.0
Blood Red Count	4.6	44.8	49.9	-7.1	-6.3
Illness, injury, bereavement, stress in last 2 years	3.8	4.7	5.9	-2.4	-1.8
Mineral and other dietary supplements	3.8	5.2	8.3	-2.9	-1.4
Wears glasses or contact lenses	3.8	4.3	4.8	2.2	2.0
High blood pressure	3.6	10.0	12.3	-3.5	-2.8
Medication: Ibuprofen (e.g. Nurofen)	3.4	4.4	8.3	2.9	0.7
Medication: Blood pressure	3.3	5.8	8.5	-2.9	-1.7
Illnesses of siblings: Diabetes	3.2	4.0	5.7	1.5	2.4
Smoking Status	3.0	7.2	9.0	2.3	3.0
Frequency of depressed mood in last 2 weeks	2.7	3.8	4.7	-1.7	-2.2
Pulse rate, automated reading	2.7	8.8	12.6	3.6	2.2
Hypertension (Self-reported)	2.6	7.3	7.9	-2.8	-2.6
Smoking status: Current	2.6	4.2	4.3	2.0	2.1
Number of operations (self-reported)	2.6	3.9	4.9	2.2	1.7
Cardiovascular Disease	2.5	8.2	9.8	-3.1	-2.6
Current tobacco smoking	2.5	4.0	4.4	1.9	2.1
Average weekly fortified wine intake	2.5	2.9	3.3	-1.8	-1.6
Sensitivity / hurt feelings	2.4	4.1	5.2	-2.3	-1.7
Prospective memory result	2.4	3.0	4.2	-2.1	-1.3
Commuting to job workplace: Car/motor vehicle	2.4	2.7	4.7	-0.9	-2.2
Vascular/heart problems diagnosed by doctor	2.4	6.5	9.4	3.1	1.9
Angina	2.3	3.0	4.5	-2.1	-1.3
Medication: Ramipril	2.3	2.9	5.8	-2.4	-0.2
Heart attack/myocardial infarction (self-reported)	2.3	3.0	3.3	1.8	1.6
Depression (Nagel 2018)	2.2	3.4	5.9	-0.9	-2.4
Mean Putamen Volume	2.2	2.5	3.1	-1.8	-1.3
Neuroticism (2016)	2.2	3.2	4.6	-1.3	-2.1
Father’s age at death	2.2	2.9	3.1	1.8	1.6
Eye problems/disorders: None of the above	2.2	2.5	4.3	-2.1	-0.9
Hand grip strength (left)	2.1	5.5	7.3	-1.9	-2.7
Peak expiratory flow (PEF)	2.0	4.7	5.6	-2.0	-2.4
Ever had bowel cancer screening	2.0	2.4	4.2	-0.8	-2.0
Lung FEV1/FVC ratio	1.9	9.5	17.8	4.2	-1.1
Supplements: Glucosamine	1.9	2.5	4.2	2.1	0.9
Heart attack	1.9	2.4	2.9	1.7	1.4
Handedness (chirality/laterality): Left-handed	1.9	2.3	2.4	-1.5	-1.5
Commuting to job workplace: Cycle	1.9	2.3	3.2	-1.8	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	2.9	-1.4	-1.7
Mouth/teeth dental problems	1.8	2.8	3.3	-1.5	1.8
Breastfed as a baby	1.8	2.3	3.4	1.0	1.9
Tense / ‘highly strung’	1.8	3.1	3.2	-1.7	-1.8
Fractured/broken bones in last 5 years	1.8	2.3	3.6	0.9	-1.9
Neuroticism	1.7	4.1	4.1	-2.0	-2.0
Qualifications: CSEs or equivalent	1.7	2.3	3.4	-1.8	-1.1
Angina (self-reported)	1.7	2.2	3.1	-1.8	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	1.9	3.1	-1.8	-0.9
Bipolar Disorder or Schizophrenia	1.6	3.9	4.6	-1.8	-2.2
Schizophrenia (2018)	1.6	3.3	3.9	-1.6	-2.0
Townsend deprivation index at recruitment	1.6	2.3	2.7	1.4	1.6
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.7	5.4	-2.3	-1.4
Medication: Lansoprazole	1.6	1.8	2.2	1.2	1.5
Pulse wave reflection index	1.6	2.0	2.3	-1.5	-1.3
Diastolic blood pressure, automated reading	1.6	5.0	6.4	-2.5	-1.9
Falls in the last year	1.5	2.1	2.8	1.1	1.7
Blood clot in the leg (DVT)	1.5	2.0	2.3	1.5	1.3
Mouth/teeth dental problems: Loose teeth	1.5	1.7	3.4	0.3	-1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.7	2.2	1.1	1.5
Number of self-reported non-cancer illnesses	1.5	2.5	4.3	-0.9	-2.1
Ever taken oral contraceptive pill	1.5	1.7	2.4	0.9	1.6
Medication: Blood pressure	1.5	2.9	4.4	-2.1	-1.2
Schizophrenia (2014)	1.4	3.2	4.0	-1.5	-2.0
Lung FVC	1.4	7.2	11.0	-3.3	-1.8
Maternal smoking around birth	1.4	2.1	2.3	-1.5	-1.4
Neuroticism score	1.4	2.9	4.5	-2.1	-1.2
Depression (self-reported)	1.4	1.7	3.1	-1.8	-0.6
Worry too long after embarrassment	1.4	2.4	4.5	-2.1	0.4
Chest pain or discomfort	1.4	2.1	2.5	1.6	1.3
Medication: Bendroflumethiazide	1.4	2.1	3.0	-1.7	-1.1
Medication: Atorvastatin	1.4	1.7	2.0	-1.4	1.2
Irritability	1.4	2.4	3.1	-1.3	-1.8
Allergy or Eczema	1.3	3.3	4.8	1.4	-2.2
Number of incorrect matches in round	1.3	2.2	4.3	2.1	0.0
Hayfever/allergic rhinitis (self-reported)	1.3	1.8	2.2	1.5	-1.2
Medication: Amlodipine	1.3	1.8	3.6	-1.9	-0.1
Suffer from ‘nerves’	1.3	2.1	3.4	-0.9	-1.9
Ever smoked	1.3	2.3	4.3	2.1	0.5
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	2.8	1.7	-0.6
Medication: Co-codamol	1.2	1.4	2.5	1.6	0.6
Financial difficulties in last 2 years	1.2	1.7	3.0	1.7	0.5
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	2.0	0.8	1.4
Asthma	1.2	2.4	2.5	-1.6	-1.5
Had major operations	1.2	1.3	1.9	0.9	1.4
Illnesses of father: Heart disease	1.2	1.6	2.3	-1.5	-0.9
Illnesses of father: None of the above (group 1)	1.2	1.5	2.9	1.7	0.2
Heart disease (siblings)	1.2	1.5	2.9	1.7	-0.3
Systolic Blood Pressure	1.1	5.3	9.6	-3.1	-1.0
Leg fat-free mass (left)	1.1	6.0	9.1	-1.7	-3.0
Leg predicted mass (left)	1.1	5.9	9.4	-1.6	-3.1
Time employed in main current job	1.1	1.3	2.6	-1.6	-0.2
Qualifications: A levels/AS levels or equivalent	1.1	2.4	2.9	-1.7	-1.4
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	2.8	1.7	0.9
Leg fat-free mass (right)	1.1	5.8	8.3	-1.8	-2.9
Long-standing illness, disability or infirmity	1.1	1.6	3.2	1.8	0.2
Medication: Gliclazide	1.1	1.2	1.8	1.3	0.9
High cholesterol (Self-reported)	1.1	2.0	3.8	-1.9	-0.4
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	1.5	1.2	1.1
Serious illness, injury or assault to yourself	1.0	1.2	2.0	1.4	0.6
Hair/balding pattern: Pattern 2	1.0	1.2	1.4	-1.0	-1.2
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	1.7	-0.8	-1.3
Qualifications: nursing, teaching	1.0	1.6	2.2	-1.5	-1.0
Asthma (self-reported)	1.0	2.1	2.3	-1.3	-1.5
Leg predicted mass (right)	1.0	5.6	8.0	-1.8	-2.8
Arm predicted mass (left)	1.0	5.0	6.9	-1.7	-2.6
Schizophrenia vs Biploar Disorder	0.9	1.2	1.9	-0.7	-1.4
Body Mass Index (BMI) (2010)	0.9	1.2	2.4	-1.6	0.1
Average weekly spirits intake	0.9	1.2	2.0	1.4	0.5
Past tobacco smoking	0.9	1.7	3.0	-1.7	-0.6
Forced vital capacity (FVC)	0.9	3.5	5.4	-2.3	-1.2
Illnesses of siblings	0.9	1.3	2.1	-0.7	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	2.1	-1.3	-1.5
Diabetes diagnosed by doctor	0.9	1.5	2.9	-0.4	-1.7
Commuting to job workplace: Walk	0.9	0.9	1.5	-0.6	1.2
Basal metabolic rate	0.9	4.8	7.8	-1.3	-2.8
Arm fat-free mass (left)	0.9	4.8	6.9	-1.6	-2.6
Heel T-Score	0.8	6.5	11.8	-3.4	-1.1
Severe depression (siblings)	0.8	0.9	1.6	-0.5	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	3.3	-1.8	-0.6
Medication: Atenolol	0.8	1.1	2.1	-1.5	0.1
Nervous feelings	0.8	1.5	1.5	-1.2	-1.2
Pain all over the body in last month	0.8	0.9	1.6	-0.5	1.3
Medication: Cholesterol lowering	0.8	1.3	2.6	-1.6	0.1
Forced vital capacity (FVC), Best measure	0.8	2.8	4.6	-2.1	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	1.3	-1.1	-0.8
Family relationship satisfaction	0.8	1.0	1.6	-1.3	-0.6
Eye problems/disorders: Cataract	0.8	1.0	1.6	1.3	0.6
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.5	0.1	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.8	2.0	-1.3	-1.4
Whole body water mass	0.8	4.4	6.8	-1.4	-2.6
Hearing aid user	0.8	0.9	1.4	-1.2	0.6
Mother’s age at death	0.8	1.0	2.0	-0.1	1.4
Worry (Nagel 2018)	0.7	1.4	2.6	-0.4	-1.6
Coronary Artery Disease (CAD)	0.7	0.9	1.4	-1.2	-0.6
HbA1C	0.7	0.8	1.4	-1.2	0.4
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.4	0.6	1.2
Vitamin and mineral supplements	0.7	1.0	2.0	-1.4	0.2
Supplements: Zinc	0.7	0.8	1.0	-0.7	-1.0
Hayfever, allergic rhinitis or eczema	0.7	1.5	2.9	0.4	-1.7
Diabetes (self-reported)	0.7	1.0	2.0	-0.1	-1.4
Medication: Simvastatin	0.7	1.1	2.0	-1.4	-0.4
Weight	0.7	3.4	6.3	-0.7	-2.5
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	3.2	-1.3	-1.8
Lung cancer (father)	0.7	0.8	1.4	-0.5	-1.2
Birth weight of first child	0.7	1.2	2.2	1.5	-0.4
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.7	1.3	-0.2
Neck or shoulder pain in last month	0.7	1.0	1.9	1.4	-0.3
Leg pain on walking	0.7	0.9	1.3	-0.7	-1.1
Whole body fat-free mass	0.7	4.1	6.6	-1.3	-2.6
Average weekly red wine intake	0.7	1.0	1.7	-1.3	0.6
Osteoporosis (self-reported)	0.7	0.9	1.5	1.2	-0.5
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.7	0.2	-1.3
Intelligence (Savage-Jansen 2018)	0.6	1.9	2.4	1.5	1.2
Neuroticism (Nagel 2018)	0.6	1.4	1.7	-1.3	-1.0
Alzheimer’s Disease (in father)	0.6	0.6	1.1	0.3	1.1
Medication for hormone replacement therapy	0.6	0.6	1.2	0.1	1.1
Diabetes (mother)	0.6	0.8	1.5	-1.2	-0.1
Hand grip strength (right)	0.6	1.6	2.2	-1.0	-1.5
Impedance of leg (left)	0.6	2.7	4.1	1.2	2.0
Arm fat mass (right)	0.6	2.4	4.2	-0.8	-2.1
Gout (self-reported)	0.6	0.8	1.4	-1.2	0.5
Arm fat-free mass (right)	0.6	2.9	3.9	-1.4	-2.0
Arm predicted mass (right)	0.6	3.0	4.4	-1.3	-2.1
Supplements: Vitamin C	0.6	0.8	1.2	1.1	0.6
Average weekly champagne plus white wine intake	0.6	0.9	1.7	0.0	-1.3
Financial situation satisfaction	0.6	0.8	1.4	-0.3	-1.2
Unable to work because of sickness or disability	0.6	0.7	1.5	0.1	1.2
Bipolar Disorder (2018)	0.5	0.8	1.0	-0.8	-1.0
Crohns Disease (2012)	0.5	0.8	0.9	1.0	-0.8
Fasting Glucose	0.5	0.5	1.0	0.2	1.0
LDL Cholesterol	0.5	0.9	1.3	-1.2	0.6
Blood Platelet Count	0.5	6.0	8.3	1.9	2.9
Blood White Count	0.5	3.6	7.0	0.3	2.6
BMI	0.5	2.7	4.4	-1.0	-2.1
Chronotype (morning person)	0.5	1.2	1.4	1.0	1.2
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	0.7	-0.8	-0.6
Diabetes (father)	0.5	0.7	0.7	-0.8	-0.8
Impedance of leg (right)	0.5	2.5	2.9	1.5	1.7
Fed-up feelings	0.5	1.0	1.5	-1.2	-0.7
Taking other prescription medications	0.5	0.8	1.1	1.0	-0.8
Sitting height	0.5	3.3	3.4	-1.8	-1.8
Had other major operations	0.5	0.7	1.2	0.3	1.1
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	0.7	-0.8	0.8
Allergy	0.5	1.1	2.2	-0.0	1.5
Hip circumference	0.5	2.2	4.4	-0.3	-2.1
Mouth/teeth dental problems: Dentures	0.5	0.9	1.3	0.7	-1.1
Trunk predicted mass	0.5	2.8	4.8	-0.8	-2.2
Glaucoma (self-reported)	0.5	0.5	0.9	0.4	0.9
Number of children fathered	0.5	0.6	0.8	0.6	0.9
Age at first live birth	0.5	1.0	1.9	-1.4	-0.2
Mean time to correctly identify matches	0.5	1.0	1.7	1.3	-0.4
Medication: Aspirin	0.5	0.7	1.1	-1.0	-0.6
Arm fat mass (left)	0.5	1.9	3.4	-0.6	-1.8
Miserableness	0.5	0.8	0.9	-0.8	-1.0
Ever depressed for a whole week	0.5	0.6	0.7	-0.7	-0.8
Reaction Time	0.4	0.8	1.1	0.6	-1.1
Ovarian Cancer	0.4	0.5	0.8	0.9	0.3
Respiratory disease	0.4	0.8	1.6	0.3	-1.3
Medication: Metformin	0.4	0.6	1.1	1.1	0.3
Medication: Levothyroxine sodium	0.4	0.6	1.0	-0.5	-1.0
Trunk fat mass	0.4	1.6	3.2	-0.2	-1.8
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.2	-1.1	-0.2
Fluid intelligence score	0.4	0.8	0.9	0.8	1.0
Trunk fat-free mass	0.4	2.5	4.4	-0.7	-2.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.1	1.4	-0.9	-1.2
Standing height	0.4	3.9	7.0	-0.9	-2.6
Length of working week for main job	0.4	0.4	0.6	-0.8	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.0	-1.0	-0.6
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.8	-0.4	0.9
Medication: Paracetamol	0.4	0.6	1.2	-1.1	-0.1
Birth weight	0.4	0.9	1.6	1.2	0.5
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.9	0.3	1.0
Medication: Allopurinol	0.4	0.5	1.0	0.1	1.0
Heart disease (mother)	0.4	0.4	0.8	-0.3	-0.9
Medication for cholesterol	0.4	0.6	0.8	0.9	0.7
Back pain experienced in last month	0.4	0.6	0.6	0.8	0.7
Tinnitus: Yes, now most or all of the time	0.4	0.4	0.6	0.5	0.8
Commuting to job workplace: Public transport	0.4	0.5	0.7	-0.5	0.9
Medication: Paracetamol	0.4	0.6	1.1	-0.0	1.1
Average weekly beer plus cider intake	0.4	0.6	0.8	-0.9	0.6
Ever had prostate specific antigen (PSA) test	0.4	0.5	0.6	-0.7	-0.7
Depressed Affect (Nagel 2018)	0.3	0.7	1.0	-1.0	-0.6
Number of treatments/medications taken	0.3	0.5	0.9	-0.2	-1.0
Hearing difficulty/problems: Yes	0.3	0.5	0.9	1.0	0.3
Pack years adult smoking proportion	0.3	0.4	0.8	-0.2	-0.9
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.7	0.0	0.8
Multivitamins +/- minerals	0.3	0.4	0.5	0.7	-0.5
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.6	-0.4	0.8
Chronic bronchitis/emphysema (father)	0.3	0.4	0.8	-0.9	-0.1
Body mass index (BMI)	0.3	1.1	2.0	-0.5	-1.4
Qualifications: None of the above	0.3	0.7	1.1	0.6	1.1
Arm fat percentage (right)	0.3	1.1	2.1	-0.4	-1.5
Number of live births	0.3	0.5	0.6	0.8	0.5
Pulse wave Arterial Stiffness index	0.3	0.4	0.7	0.3	-0.8
Pulse wave peak to peak time	0.3	0.4	0.6	-0.5	0.8
Health satisfaction	0.3	0.3	0.6	0.8	-0.3
Emphysema/chronic bronchitis	0.3	0.4	0.4	0.6	0.7
Migraine (self-reported)	0.3	0.4	0.8	0.9	0.1
Medication: Omeprazole	0.3	0.3	0.6	-0.2	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.5	0.7	0.4
Whole body fat mass	0.3	1.3	2.6	-0.3	-1.6
Alcohol intake frequency.	0.3	0.7	1.1	1.0	-0.6
Mood swings	0.3	0.6	1.1	-1.1	-0.2
Medication: Lisinopril	0.3	0.4	0.7	0.8	0.0
Basal cell carcinoma (self-reported)	0.3	0.4	0.4	-0.6	-0.6
Alcohol drinker status: Previous	0.3	0.3	0.6	0.8	0.2
Pack years of smoking	0.3	0.4	0.8	0.1	-0.9
Verbal and Numeric Reasoning (VNR)	0.2	0.6	0.7	0.7	0.8
Triglycerides	0.2	0.4	0.6	-0.4	0.8
Height	0.2	4.2	7.0	-1.2	-2.6
Waist Hip Ratio (WHR)	0.2	1.1	1.9	0.4	1.4
Hypothyroidism (self reported)	0.2	0.5	0.8	-0.4	-0.9
Relative age of first facial hair	0.2	0.4	0.9	0.9	0.0
Trunk fat percentage	0.2	1.0	1.9	-0.0	-1.4
Relative age voice broke	0.2	0.4	0.6	-0.8	0.3
Age when periods started (menarche)	0.2	0.5	0.9	0.2	-1.0
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	0.3	-0.6
Stomach or abdominal pain in last month	0.2	0.3	0.3	-0.5	0.5
Waist circumference	0.2	0.6	1.0	0.4	-1.0
Hearing difficulty/problems with background noise	0.2	0.3	0.5	0.4	0.7
Worrier / anxious feelings	0.2	0.4	0.8	-0.2	-0.9
Loud music exposure frequency	0.2	0.2	0.3	0.5	0.3
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.5	-0.7	-0.6
Headache pain in last month	0.2	0.4	0.8	0.0	-0.9
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.7	0.1	-0.8
Body fat percentage	0.2	0.6	1.3	0.0	-1.1
Leg fat percentage (right)	0.2	0.8	1.6	1.2	0.2
Comparative body size at age 10	0.2	0.6	1.0	-1.0	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.6	-0.8	-0.2
Shortness of breath walking on level ground	0.2	0.3	0.5	0.7	-0.0
Medication for pain relief, constipation, heartburn	0.2	0.3	0.6	0.8	0.1
Medication: Seretide 50 evohaler	0.2	0.2	0.2	0.5	-0.5
Leg fat mass (right)	0.2	0.9	1.8	0.2	-1.4
Number of full sisters	0.2	0.2	0.4	0.6	0.3
Age at last live birth	0.2	0.2	0.3	-0.3	0.6
Smoking status: Previous	0.2	0.3	0.5	0.7	0.3
Arm fat percentage (left)	0.2	0.6	1.3	-0.1	-1.1
Loneliness, isolation	0.2	0.3	0.5	-0.7	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	0.7	-0.1
Guilty feelings	0.2	0.3	0.4	-0.3	0.6
Eye problems/disorders: Glaucoma	0.2	0.3	0.4	0.4	0.6
Illnesses of father: High blood pressure	0.2	0.3	0.4	-0.6	-0.4
Alcohol drinker status: Never	0.2	0.2	0.3	-0.4	-0.5
Leg fat percentage (left)	0.2	0.6	1.2	1.1	0.3
Cholesterol lowering medication	0.2	0.3	0.7	-0.8	-0.1
Supplements: Calcium	0.2	0.2	0.2	0.5	-0.5
Impedance of whole body	0.2	0.8	1.3	0.6	1.1
Crohns Disease (2017)	0.1	0.1	0.3	0.0	-0.5
Ulcerative Colitis (UC)	0.1	0.2	0.4	-0.0	0.6
Age at First Birth	0.1	0.2	0.2	-0.4	-0.5
HDL Cholesterol	0.1	0.2	0.3	0.5	-0.4
Lupus	0.1	0.1	0.1	-0.3	-0.4
Primary Biliary Cirrhosis	0.1	0.1	0.2	0.3	-0.4
Rheumatoid Arthritis	0.1	0.1	0.2	0.4	-0.1
Ulcerative Colitis	0.1	0.1	0.3	-0.1	0.5
Blood Eosinophil Count	0.1	0.7	1.4	-0.3	1.2
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.2	-0.2	-0.4
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.1	0.1	0.4
Systolic blood pressure, automated reading	0.1	0.3	0.6	-0.8	0.0
Impedance of arm (right)	0.1	0.3	0.3	0.5	0.5
Alcohol intake versus 10 years previously	0.1	0.2	0.3	0.1	-0.6
Happiness	0.1	0.1	0.3	0.0	0.5
Illnesses of mother	0.1	0.1	0.1	0.3	-0.3
Impedance of arm (left)	0.1	0.6	0.6	0.8	0.7
Exposure to tobacco smoke at home	0.1	0.1	0.1	0.1	-0.4
Hair/balding pattern: Pattern 4	0.1	0.2	0.4	0.3	0.6
High blood pressure (siblings)	0.1	0.2	0.3	0.4	0.5
Exposure to tobacco smoke outside home	0.1	0.1	0.3	-0.1	-0.5
Qualifications: College or University degree	0.1	0.2	0.3	-0.6	-0.3
Comparative height size at age 10	0.1	0.7	1.1	-0.4	-1.1
Overall health rating	0.1	0.2	0.2	0.3	-0.5
Osteoarthritis (self-reported)	0.1	0.1	0.1	0.3	-0.3
Medication: Aspirin	0.1	0.2	0.3	-0.6	-0.2
Risk taking	0.1	0.2	0.2	-0.5	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	-0.1	0.5
Leg fat mass (left)	0.1	0.5	1.1	0.0	-1.0
Alzheimer’s Disease (in mother)	0.0	0.0	0.1	0.3	-0.1
Alzheimer’s Disease (including proxy)	0.0	0.1	0.1	0.0	-0.3
Irritable Bowel Disease (IBD)	0.0	0.0	0.0	0.1	0.1
Major Depression (MDD)	0.0	0.0	0.0	-0.2	0.0
Breast Cancer	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.1	0.3	0.2	0.5
Tanning	0.0	0.5	0.5	0.7	0.7
Ever had hysterectomy (womb removed)	0.0	0.0	0.0	-0.0	-0.1
High blood pressure (mother)	0.0	0.0	0.0	-0.1	0.0
Alcohol usually taken with meals	0.0	0.1	0.1	-0.3	-0.3
Had menopause	0.0	0.0	0.0	-0.2	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.0	0.1	0.2	-0.0
Hair/balding pattern: Pattern 3	0.0	0.1	0.1	0.2	0.3
Noisy workplace	0.0	0.0	0.1	0.0	-0.3
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.0	0.2	0.0
Wheeze or whistling in the chest in last year	0.0	0.1	0.1	0.0	-0.3
Knee pain experienced in last month	0.0	0.0	0.1	-0.0	-0.3
Friendships satisfaction	0.0	0.0	0.0	0.0	0.1
Breast cancer (self-reported)	0.0	0.0	0.0	-0.2	0.0
Age started oral contraceptive pill	0.0	0.0	0.0	-0.1	0.0
Myopia	0.0	0.0	0.0	0.2	-0.1
Pain experienced in last month	0.0	0.1	0.1	-0.2	0.4

Hub : Genes

ACVRL1

Models

Trait associations