TWAS hub - AFAP1L1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1200	0.0460	3.1e-03	0.007	NA	0.005	NA	0.007	8.3e-02	NA	1.1e-01	NA	8.3e-02
2	GTEx	Brain Cerebellar Hemisphere	0.4300	0.1220	2.0e-03	0.195	NA	0.077	NA	0.022	9.7e-06	NA	5.1e-03	NA	9.0e-02
3	GTEx	Brain Frontal Cortex BA9	0.2991	0.0951	7.9e-04	0.005	NA	-0.011	NA	0.014	2.4e-01	NA	8.5e-01	NA	1.3e-01
4	GTEx	Brain Nucleus accumbens basal ganglia	0.1500	0.0620	6.2e-03	0.117	NA	0.085	NA	0.108	5.0e-04	NA	2.8e-03	NA	8.0e-04
5	GTEx	Cells Transformed fibroblasts	0.1710	0.0420	5.4e-07	0.102	NA	0.146	NA	0.128	4.4e-08	NA	4.7e-11	NA	8.2e-10
6	GTEx	Colon Transverse	0.2200	0.0770	2.3e-03	-0.006	NA	0.003	NA	0.005	9.4e-01	NA	2.3e-01	NA	1.8e-01
7	GTEx	Muscle Skeletal	0.2430	0.0464	5.8e-11	0.171	NA	0.232	NA	0.214	1.4e-16	NA	1.7e-22	NA	1.1e-20
8	METSIM	Adipose	0.0985	0.0275	1.3e-06	0.029	0.036	0.033	0.035	0.039	2.8e-05	3.7e-06	7.5e-06	4.9e-06	1.6e-06
9	TCGA	Bladder Urothelial Carcinoma	0.0450	0.0230	1.6e-03	0.027	0.027	0.024	NA	0.025	2.3e-03	2.3e-03	3.8e-03	NA	3.2e-03
10	TCGA	Cervical Squamous Cell Carcinoma	0.1220	0.0650	2.9e-03	0.027	0.022	0.043	NA	0.011	1.7e-02	2.7e-02	3.4e-03	NA	8.4e-02
11	TCGA	Head and Neck Squamous Cell Carcinoma	0.0361	0.0197	2.1e-03	0.009	0.015	0.011	NA	0.007	3.3e-02	7.8e-03	1.9e-02	NA	4.3e-02
12	TCGA	Kidney Renal Papillary Cell Carcinoma	0.2660	0.0710	1.0e-09	0.118	0.129	0.107	NA	0.140	2.8e-07	7.7e-08	1.1e-06	NA	2.1e-08
13	TCGA	Liver Hepatocellular Carcinoma	0.0930	0.0460	4.5e-03	0.012	0.036	0.014	NA	0.012	8.5e-02	8.3e-03	7.1e-02	NA	8.4e-02
14	TCGA	Lung Adenocarcinoma	0.0233	0.0134	8.5e-03	0.010	0.015	0.005	NA	0.012	2.4e-02	6.3e-03	7.2e-02	NA	1.4e-02
15	TCGA	Lung Squamous Cell Carcinoma	0.0211	0.0112	5.3e-03	0.015	0.017	0.013	NA	0.012	6.3e-03	4.3e-03	1.1e-02	NA	1.3e-02
16	TCGA	Ovarian Serous Cystadenocarcinoma	0.0770	0.0400	1.1e-03	0.035	0.046	0.032	NA	0.024	1.9e-03	4.2e-04	3.0e-03	NA	9.0e-03
17	TCGA	Prostate Adenocarcinoma	0.0654	0.0299	7.4e-05	0.048	0.052	0.060	NA	0.056	7.8e-06	3.6e-06	6.3e-07	NA	1.5e-06
18	TCGA	Stomach Adenocarcinoma	0.0500	0.0270	5.3e-03	0.013	0.035	0.025	NA	0.019	3.5e-02	1.5e-03	6.4e-03	NA	1.4e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Hearing difficulty/problems: Yes	8.1	12.4	19.6	3.1	-0.2	-1.3	-1.5	4.3	2.5	2.9	3.9	4.1	3.0	4.2	4.4	4.0	4.0	4.2	4.3	4.0	3.8
Lung FVC	6.5	33.1	52.4	-5.3	2.4	1.3	5.1	-7.0	-4.4	-5.9	-4.3	-6.5	-5.5	-6.7	-6.3	-5.5	-6.9	-7.1	-6.6	-7.2	-5.8
Friendships satisfaction	5.4	6.7	12.5	-2.2	-0.1	2.4	0.9	-3.4	-1.8	-2.4	-2.9	-3.1	-3.2	-2.5	-3.2	-2.4	-2.8	-3.5	-2.4	-2.9	-2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	5.3	11.2	17.6	-3.1	2.9	1.2	2.9	-4.2	-1.3	-3.3	-2.6	-3.5	-3.4	-4.2	-3.9	-3.5	-3.5	-4.2	-3.6	-3.9	-3.4
Severe depression (siblings)	5.1	5.7	12.5	1.5	-0.4	-0.3	-1.1	2.8	1.5	2.0	2.2	2.9	2.6	3.0	1.7	2.4	3.3	3.1	3.0	2.3	3.5
Frequency of depressed mood in last 2 weeks	5.0	7.0	12.4	2.9	-0.3	-1.0	-1.3	3.2	3.0	2.6	3.3	3.2	3.5	2.4	2.6	2.2	3.1	3.0	2.2	3.0	2.4
Forced expiratory volume in 1-second (FEV1), Best measure	4.5	14.4	23.6	-3.1	2.8	1.2	3.7	-4.7	-1.9	-4.6	-1.5	-4.4	-4.4	-3.8	-4.8	-2.9	-4.8	-4.4	-3.5	-4.9	-4.0
Forced expiratory volume in 1-second (FEV1)	4.3	14.4	23.8	-3.1	2.2	1.0	3.3	-4.5	-2.7	-4.6	-1.5	-4.4	-4.4	-3.8	-4.5	-3.2	-4.7	-4.3	-3.9	-4.9	-4.1
Illnesses of father: None of the above (group 1)	3.8	4.8	14.8	-2.0	2.7	0.6	0.1	-2.6	-1.0	-3.8	-1.6	-1.7	-2.3	-2.8	-2.0	-2.5	-1.4	-2.6	-2.1	-2.6	-1.5
Illnesses of father: Heart disease	3.7	5.1	15.5	2.5	-2.6	-1.0	0.4	2.4	1.0	3.9	1.6	1.8	2.1	2.5	2.5	2.4	1.8	2.4	2.6	2.4	2.1
Medication: Omeprazole	3.6	4.3	7.7	2.2	0.1	-0.5	-0.7	2.3	1.2	2.2	2.0	2.1	2.5	2.4	2.1	2.0	2.5	2.4	2.8	2.2	2.5
High blood pressure	3.5	9.6	24.8	1.9	-3.4	-0.1	1.8	4.1	0.5	5.0	2.3	3.1	4.3	3.3	2.7	3.2	2.8	4.2	2.7	3.5	2.8
Medication: Omeprazole (e.g. Zanprol)	3.5	4.3	8.5	2.1	-0.5	-0.1	0.1	2.3	1.0	2.3	2.0	2.0	2.6	2.3	2.0	2.1	2.6	2.3	2.9	2.1	2.7
Lung FEV1/FVC ratio	3.4	17.4	31.4	-3.9	1.4	3.5	3.1	-5.2	-2.8	-4.7	-4.1	-4.5	-3.6	-4.7	-5.2	-4.2	-4.1	-5.0	-3.7	-5.6	-3.5
Forced vital capacity (FVC)	3.3	12.6	21.9	-2.9	2.1	0.1	3.0	-4.1	-2.7	-4.0	-1.3	-4.2	-4.2	-3.5	-4.1	-2.9	-4.7	-4.0	-3.9	-4.4	-4.1
Vascular/heart problems diagnosed by doctor	3.2	8.6	23.5	-1.8	3.2	0.4	-1.9	-3.9	-0.3	-4.8	-2.4	-3.0	-4.0	-2.8	-2.3	-2.9	-2.8	-3.8	-2.5	-3.2	-2.9
Number of children fathered	3.1	3.5	11.2	-1.6	2.4	1.2	0.7	-2.3	-0.1	-3.3	-1.7	-2.0	-1.2	-1.8	-1.6	-2.0	-1.7	-2.1	-1.3	-2.2	-2.0
Hypertension (Self-reported)	3.1	8.5	21.1	1.8	-3.0	-0.1	1.8	3.9	0.4	4.6	2.3	2.9	3.9	3.1	2.6	3.1	2.6	3.9	2.6	3.2	2.5
Body Mass Index (BMI) (2010)	3.0	4.1	9.2	-2.0	0.5	1.6	0.4	-2.5	-1.1	-2.0	-2.2	-2.3	-3.0	-2.3	-1.7	-2.1	-2.1	-2.6	-1.8	-2.4	-1.6
Hearing difficulty/problems with background noise	3.0	4.8	10.8	1.2	0.4	-0.8	-2.1	2.4	2.1	1.3	2.9	2.2	1.5	2.4	2.4	2.9	2.1	2.3	3.3	1.8	2.8
Emphysema/chronic bronchitis	3.0	3.4	7.3	1.7	-0.8	-1.6	-1.6	2.5	0.4	1.9	2.7	1.8	2.4	1.9	1.6	2.0	1.5	2.4	2.0	1.5	1.6
Mouth/teeth dental problems	2.9	4.5	9.7	-2.7	0.8	-0.5	-0.2	-2.3	-1.1	-2.4	-2.4	-2.3	-3.1	-1.7	-2.1	-1.9	-2.6	-2.0	-2.3	-2.0	-2.8
Forced vital capacity (FVC), Best measure	2.9	10.8	17.7	-2.7	2.9	1.1	3.4	-3.8	-2.0	-3.7	-1.0	-3.7	-4.1	-3.2	-4.1	-2.3	-4.2	-3.7	-3.0	-4.1	-3.5
Long-standing illness, disability or infirmity	2.7	4.1	9.0	1.5	-0.8	-0.5	-0.9	2.3	1.6	2.0	2.7	2.3	2.5	2.0	1.2	1.7	2.6	2.1	2.8	1.4	3.0
Cardiovascular Disease	2.6	8.5	23.9	2.5	-2.6	0.4	1.3	3.6	0.3	4.9	2.6	3.1	3.1	3.2	2.5	3.3	2.8	3.8	2.5	3.5	2.7
Osteoarthritis (self-reported)	2.6	3.3	8.6	1.7	-1.4	0.2	-0.0	2.2	0.5	1.5	0.9	2.2	1.8	1.9	2.6	1.0	2.9	1.8	2.0	2.3	2.2
Depression (Nagel 2018)	2.4	3.6	9.5	2.0	-0.4	-0.6	-2.2	2.4	2.3	1.8	2.3	2.3	3.1	1.2	1.7	0.9	2.2	2.0	0.9	2.1	1.5
Mouth/teeth dental problems: Mouth ulcers	2.4	3.8	6.9	2.6	-1.8	-0.6	0.7	2.1	1.7	2.4	2.0	1.2	2.4	2.0	2.1	2.0	1.6	2.0	2.3	2.4	1.8
Breast Cancer	2.3	5.6	15.9	1.8	-1.4	-0.4	-4.0	2.4	1.9	2.1	2.4	1.5	1.4	2.6	2.3	2.6	2.5	2.1	3.2	2.2	3.3
Peak expiratory flow (PEF)	2.3	5.4	9.2	-1.6	0.2	0.6	2.4	-2.9	-1.4	-1.9	-1.1	-2.7	-1.9	-3.0	-2.5	-2.8	-2.8	-2.9	-3.0	-2.8	-2.6
Birth weight	2.3	5.0	9.7	2.3	0.9	3.0	0.4	2.8	0.8	1.9	2.1	3.1	0.7	2.5	2.7	2.5	2.6	2.1	1.8	2.8	2.3
Type 2 Diabetes (T2D) (2012)	2.2	2.6	5.3	-0.8	-0.6	1.4	0.2	-2.3	-1.8	-0.8	-2.0	-1.7	-1.1	-1.9	-2.2	-1.1	-2.0	-2.3	-1.8	-1.4	-1.4
Systolic Blood Pressure	2.2	10.9	23.0	2.6	-3.3	0.2	4.1	4.1	1.2	4.8	3.5	3.4	2.4	3.7	3.3	3.7	3.0	4.3	2.9	2.7	3.2
Fed-up feelings	2.2	4.0	7.6	2.3	-2.3	-0.9	-1.6	2.7	0.7	1.8	1.9	2.3	2.4	1.9	2.7	1.1	2.1	2.6	1.2	2.8	0.7
Hip circumference	2.2	9.5	16.0	-3.5	0.7	1.3	0.4	-3.3	-2.4	-2.7	-3.8	-3.7	-3.2	-3.2	-2.5	-3.4	-3.6	-4.0	-3.6	-3.7	-3.0
Alcohol drinker status: Never	2.2	2.6	6.4	1.5	-0.1	-1.0	2.2	1.9	1.4	1.1	2.1	1.4	2.2	1.5	2.5	1.0	1.7	1.8	1.6	1.2	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	2.1	3.2	7.3	2.1	-2.2	1.0	1.2	1.6	1.8	2.7	1.5	1.9	1.2	1.5	1.7	2.0	1.6	1.5	1.7	2.0	2.0
Number of incorrect matches in round	2.0	3.3	7.3	-1.7	-0.4	0.8	1.1	-2.3	-1.1	-1.4	-1.8	-2.7	-0.9	-1.7	-2.4	-1.8	-2.6	-2.2	-1.9	-1.7	-2.1
Hearing aid user	2.0	2.2	4.9	2.2	1.1	-1.0	0.2	1.7	0.4	0.8	1.8	1.9	0.8	1.4	1.7	1.7	1.6	1.3	2.0	2.0	1.2
Alzheimer’s Disease (including proxy)	1.9	2.8	5.2	-1.9	-0.1	0.1	1.4	-1.8	-1.4	-1.2	-1.6	-2.1	-1.1	-1.9	-2.3	-1.5	-2.1	-2.2	-1.7	-2.2	-1.0
Waist Hip Ratio (WHR)	1.9	8.5	16.3	3.3	-2.0	-0.5	-1.0	3.5	1.6	3.4	4.0	2.6	2.6	3.0	3.1	3.2	2.7	3.9	3.3	3.4	2.5
Other serious medical condition/disability diagnosed by doctor	1.9	2.4	5.7	1.1	0.1	-0.3	-0.2	1.7	1.3	0.9	2.0	2.0	2.2	1.7	0.7	2.0	1.8	1.4	2.1	0.9	2.4
Serious illness, injury or assault to yourself	1.9	2.3	4.7	1.6	-0.2	-1.0	-1.2	2.0	1.2	1.7	1.2	2.1	2.0	1.2	1.7	1.0	1.6	1.8	0.8	2.2	0.9
Arm fat percentage (left)	1.9	7.5	19.6	-3.4	0.5	1.0	-0.6	-3.0	-1.5	-1.6	-4.4	-3.1	-2.4	-3.0	-2.8	-3.1	-2.8	-3.8	-3.0	-3.3	-2.0
Ever had bowel cancer screening	1.9	2.3	4.5	1.7	0.7	0.3	-0.7	1.4	0.9	1.2	0.2	2.0	1.1	1.4	1.9	1.7	2.1	1.1	2.1	2.1	2.1
Neuroticism (2016)	1.8	2.6	6.7	1.6	-2.1	0.3	-0.2	1.8	1.1	2.0	1.1	1.2	2.6	1.3	2.2	1.4	1.2	1.9	1.2	1.9	1.4
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	6.1	1.8	-1.3	0.2	2.5	0.8	1.2	1.5	1.1	1.3	1.1	1.6	1.9	1.3	1.4	1.1	1.5	1.8	1.3
Ulcerative Colitis	1.7	2.5	6.1	-1.2	-0.1	-0.6	0.1	-1.7	1.0	-1.0	-2.2	-1.8	-1.9	-1.8	-1.7	-1.9	-1.8	-1.8	-1.7	-1.5	-2.5
Systolic blood pressure, automated reading	1.7	5.1	11.7	1.9	-2.2	0.8	3.1	2.6	0.8	3.4	1.7	2.2	2.6	2.1	2.9	2.0	2.1	2.4	1.8	2.0	2.3
Ever taken oral contraceptive pill	1.7	1.9	4.9	-1.3	0.3	-2.1	-1.5	-1.3	-1.1	-1.7	-1.4	-1.8	-0.5	-0.9	-0.7	-0.4	-2.2	-1.1	-1.2	-1.3	-1.8
Tinnitus: Yes, now most or all of the time	1.7	2.0	5.9	1.7	0.1	1.1	-0.0	1.4	1.1	1.4	1.5	1.1	2.4	1.6	1.5	1.7	1.2	1.4	1.6	1.6	0.9
Ulcerative Colitis (UC)	1.6	3.1	5.5	-1.7	-0.6	-2.3	-1.0	-1.6	0.7	-1.2	-2.1	-1.8	-2.1	-1.9	-1.9	-1.8	-2.0	-1.5	-1.7	-2.1	-2.3
Arm fat percentage (right)	1.6	6.3	16.4	-3.0	0.8	1.1	-0.4	-2.8	-1.5	-1.3	-4.1	-2.8	-2.3	-2.8	-2.4	-2.9	-2.5	-3.6	-2.7	-3.1	-1.6
Hair/balding pattern: Pattern 3	1.6	2.4	6.4	-1.3	1.0	0.2	-1.5	-1.9	0.1	-1.3	-2.5	-1.4	-1.7	-1.9	-1.9	-1.6	-1.2	-2.2	-1.6	-1.7	-1.1
Leg pain on walking	1.6	2.0	4.2	1.9	-1.1	-0.9	1.0	1.5	0.6	1.9	0.8	1.1	1.7	1.7	2.0	1.1	1.5	1.2	1.4	2.0	1.2
Mother’s age at death	1.6	2.0	4.7	-1.5	-0.8	-0.0	0.3	-1.4	-2.1	-1.3	-1.3	-1.7	-1.5	-1.4	-0.9	-0.9	-2.2	-1.4	-1.9	-1.5	-1.4
Pain type(s) experienced in last month: Hip pain	1.6	2.0	4.6	1.3	1.6	0.3	0.0	1.3	1.2	1.5	1.9	1.9	0.8	0.9	1.7	1.1	2.1	1.0	1.6	1.1	1.9
Chronic bronchitis/emphysema (father)	1.5	1.7	5.1	1.4	-1.4	-0.7	-1.6	1.4	1.5	1.4	2.2	0.8	1.3	1.1	1.6	1.3	0.4	0.8	0.9	1.5	0.9
Noisy workplace	1.5	1.8	3.4	1.8	-0.5	1.7	1.2	1.2	-0.7	1.7	0.9	1.8	1.5	0.6	1.6	1.1	1.6	0.5	1.0	1.8	1.6
Qualifications: A levels/AS levels or equivalent	1.5	3.2	8.3	-1.9	0.0	-0.9	1.0	-1.7	-1.0	-2.2	-1.8	-2.4	-2.4	-1.2	-2.1	-0.8	-2.9	-1.6	-1.7	-2.1	-2.0
Mouth/teeth dental problems: Bleeding gums	1.5	2.0	3.8	1.8	-0.6	2.0	0.8	1.6	0.7	1.9	0.8	1.9	1.6	0.9	1.8	0.9	1.6	1.3	1.2	1.7	1.0
Knee pain experienced in last month	1.5	2.4	4.5	1.4	-0.0	0.1	-1.3	1.7	0.7	1.9	1.7	2.0	1.7	1.5	1.6	1.6	1.9	1.5	1.5	1.5	2.1
Trunk fat percentage	1.4	5.4	12.1	-2.8	0.2	1.3	-0.7	-2.7	-1.5	-1.0	-3.5	-3.0	-2.3	-2.4	-2.2	-2.3	-2.7	-3.4	-2.4	-2.8	-1.5
Nervous feelings	1.4	2.7	6.2	2.5	-1.0	-0.2	2.1	1.4	2.1	1.1	2.1	2.0	2.1	1.6	1.4	1.9	1.2	1.2	1.0	1.6	1.3
Arm fat mass (right)	1.4	5.9	12.9	-2.9	0.3	1.1	-0.1	-2.6	-1.4	-1.3	-3.6	-2.9	-2.1	-2.7	-2.4	-3.0	-2.6	-3.4	-2.8	-2.9	-2.0
Pulse wave reflection index	1.4	1.7	4.1	0.4	-0.8	1.0	-1.4	1.2	1.6	1.4	1.0	1.4	0.5	1.8	0.8	2.0	1.1	1.5	1.5	1.2	1.6
Ever highly irritable/argumentative for 2 days	1.4	1.6	3.3	1.8	-0.6	-0.0	-0.2	1.2	0.2	1.0	1.8	1.5	1.8	1.5	1.2	0.8	1.7	1.5	1.5	1.3	1.1
Heart disease (mother)	1.4	1.7	5.8	0.9	0.1	-0.6	0.5	1.1	2.4	1.2	1.3	1.2	1.7	1.0	0.9	0.7	1.8	1.2	1.8	0.7	2.1
Supplements: Fish oil (including cod liver oil)	1.4	1.8	6.0	-1.7	0.2	0.8	0.5	-1.6	-0.5	-0.9	-2.4	-1.1	-1.4	-1.6	-1.8	-1.2	-1.1	-2.1	-0.8	-1.4	-0.1
Age at First Birth	1.3	1.9	4.8	-1.9	1.1	-1.3	-0.7	-1.2	-0.2	-1.9	-1.7	-1.4	-2.2	-1.0	-1.2	-1.2	-1.4	-0.5	-0.9	-1.2	-2.2
Mean Putamen Volume	1.3	1.4	5.1	-1.4	0.0	1.4	-0.1	-1.1	-2.2	-0.3	-1.3	-1.5	-0.5	-1.5	-1.1	-0.8	-1.2	-1.8	-0.8	-1.3	0.2
Primary Biliary Cirrhosis	1.3	1.8	4.3	-0.9	-1.1	-1.1	0.9	-1.1	-1.9	-0.8	-1.0	-1.4	-2.1	-0.9	-0.7	-1.0	-1.9	-1.1	-1.7	-1.4	-2.0
Neck or shoulder pain in last month	1.3	1.9	4.6	0.9	0.8	0.8	-1.2	1.7	-0.8	1.5	1.6	2.1	0.1	1.4	0.7	1.9	1.5	1.3	1.7	1.4	1.7
Overall health rating	1.3	2.8	8.8	1.4	-0.9	-0.1	-0.9	2.3	-0.1	3.0	0.8	1.7	1.8	1.8	1.9	1.2	2.1	1.6	1.6	2.1	1.8
Arm fat mass (left)	1.3	5.4	12.5	-2.8	-0.1	0.9	-0.2	-2.4	-1.3	-1.1	-3.5	-2.8	-1.9	-2.6	-2.3	-2.9	-2.6	-3.2	-2.8	-2.7	-1.9
Financial situation satisfaction	1.3	1.7	5.2	-0.8	-0.3	-0.1	-0.4	-1.4	-1.2	-0.3	-2.3	-1.4	-0.9	-1.1	-1.2	-1.3	-1.8	-1.7	-1.7	-0.9	-1.8
Medication: Bendroflumethiazide	1.3	2.0	5.5	0.6	-1.0	-0.4	0.3	1.7	2.4	1.7	1.1	1.0	1.8	1.8	1.3	1.2	1.4	1.9	1.8	1.1	1.4
Medication: Lisinopril	1.3	1.7	4.1	2.0	-0.7	0.3	0.4	1.8	0.7	2.0	1.3	1.9	0.4	1.4	1.2	1.0	1.8	1.3	0.6	1.4	1.0
Depressed Affect (Nagel 2018)	1.2	2.4	8.3	1.4	-2.9	-0.3	-1.9	1.8	1.4	2.0	0.7	1.3	1.9	1.1	1.8	0.3	1.2	2.0	0.4	2.3	0.0
Average weekly spirits intake	1.2	1.5	4.1	-1.3	-0.9	-0.1	0.6	-1.2	-0.6	-0.5	-2.0	-1.3	-1.9	-1.2	-1.1	-0.7	-1.5	-1.7	-1.2	-1.5	-0.6
Gout (self-reported)	1.2	1.6	5.3	-1.3	-1.1	-0.9	1.0	-1.2	-1.0	-0.8	-1.2	-2.2	-1.2	-0.9	-1.3	-0.1	-2.3	-1.6	-1.1	-1.5	-0.8
Medication: Ventolin 100micrograms inhaler	1.2	1.5	4.5	-1.1	-0.3	-0.1	-0.2	-0.9	-2.0	0.2	-2.1	-1.3	-1.5	-1.2	-0.5	-1.4	-1.5	-1.3	-1.5	-0.7	-1.6
Body fat percentage	1.2	4.8	11.2	-2.6	0.4	1.5	-0.7	-2.5	-1.1	-0.9	-3.3	-2.7	-1.7	-2.4	-2.2	-2.3	-2.4	-3.3	-2.4	-2.6	-1.4
Miserableness	1.2	2.0	5.4	0.9	-2.3	-0.9	-0.7	1.8	0.4	0.8	1.0	0.8	1.9	1.6	2.1	1.1	0.8	2.3	1.3	2.1	0.3
Illnesses of father: High blood pressure	1.2	1.5	6.6	1.2	-1.7	0.2	-0.0	1.6	-0.1	2.6	0.5	1.2	0.8	1.3	1.1	0.7	1.1	1.9	0.3	1.7	0.4
Risk taking	1.2	1.8	4.8	1.4	-0.7	-0.0	-1.8	1.6	0.4	2.2	0.2	1.1	1.1	1.5	1.5	1.4	1.1	1.1	1.5	1.8	1.5
Worry (Nagel 2018)	1.1	2.4	10.8	2.0	-1.2	0.7	0.6	1.5	1.8	1.7	1.2	1.4	3.3	1.4	0.9	1.0	1.4	1.2	1.1	1.8	1.3
Medication: Atenolol	1.1	1.4	6.0	0.7	-0.9	-0.0	-1.1	1.1	2.5	1.9	1.2	1.1	0.7	0.8	0.8	0.5	1.4	0.7	1.1	0.4	1.7
Alcohol usually taken with meals	1.1	1.8	5.0	-0.9	0.2	-0.2	-0.0	-1.7	-1.0	-0.9	-1.8	-2.2	-1.7	-1.3	-1.2	-1.8	-1.5	-1.6	-1.1	-1.0	-1.7
Financial difficulties in last 2 years	1.1	1.5	3.7	1.2	-1.0	0.3	-1.1	1.5	1.9	1.8	0.8	1.5	0.5	1.1	1.2	1.3	1.0	1.3	0.9	1.8	0.9
Depression (self-reported)	1.1	1.4	6.9	-0.0	0.7	1.1	-2.2	0.8	0.7	0.5	0.9	0.9	-0.2	1.1	0.1	1.9	0.9	0.1	1.5	0.3	2.6
Medication: Lansoprazole	1.1	1.3	3.2	1.8	-1.4	-1.7	0.5	0.9	-0.8	1.5	1.6	0.6	1.5	0.5	0.7	0.8	0.9	0.4	0.9	0.9	1.2
Alcohol intake frequency.	1.1	2.6	6.8	1.4	-0.1	-0.6	1.3	2.0	0.8	1.8	1.3	1.7	1.9	1.4	2.6	1.1	2.2	2.1	1.6	1.9	1.1
Eye problems/disorders: Glaucoma	1.1	1.3	2.7	-0.1	0.1	1.2	-1.1	-1.1	-1.2	-1.3	-0.2	-0.9	-1.6	-1.3	-1.1	-1.1	-1.2	-1.1	-1.3	-1.0	-1.6
Heart disease (siblings)	1.1	1.3	4.8	-2.2	0.9	0.5	-0.3	-0.8	-1.7	-1.1	-1.7	-1.2	-1.2	-0.8	-0.6	-0.9	-0.6	-1.3	-0.2	-2.0	-0.1
BMI	1.0	6.0	13.3	-2.6	-0.4	2.1	0.5	-2.8	-2.5	-1.0	-3.4	-2.6	-2.1	-2.7	-2.4	-2.9	-2.2	-3.6	-2.5	-3.1	-1.4
Body mass index (BMI)	1.0	4.1	10.7	-2.3	0.1	0.8	0.1	-2.1	-1.7	-1.1	-3.3	-2.1	-1.5	-2.4	-1.5	-2.8	-1.7	-2.9	-2.4	-2.5	-1.5
Trunk fat mass	1.0	4.3	9.5	-2.3	-0.2	1.0	-0.3	-2.3	-1.2	-0.7	-3.0	-2.8	-1.9	-2.2	-1.8	-2.2	-2.7	-3.1	-2.4	-2.3	-1.7
Alcohol intake versus 10 years previously	1.0	1.5	3.6	1.0	-0.7	0.8	0.5	1.7	0.6	1.9	0.8	1.7	0.1	0.9	1.5	1.3	1.6	1.4	1.3	1.8	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.6	0.4	-0.0	0.4	-1.6	1.3	1.4	1.5	1.1	1.4	0.5	0.7	1.2	1.4	1.1	1.1	0.8	1.0	1.6
Whole body fat mass	1.0	4.4	9.4	-2.3	-0.1	1.3	-0.2	-2.3	-1.1	-0.8	-2.8	-2.7	-1.6	-2.3	-2.0	-2.5	-2.5	-3.1	-2.5	-2.4	-1.7
Suffer from ‘nerves’	1.0	1.6	4.1	1.7	-0.6	-0.5	1.5	1.2	1.0	0.8	1.9	1.3	2.0	1.3	0.6	1.0	1.3	1.1	1.2	1.1	1.5
Had major operations	1.0	1.2	2.7	-1.0	0.2	0.6	-1.4	-1.0	0.8	-1.1	-0.3	-0.9	-0.9	-1.6	-1.3	-1.4	-1.1	-0.9	-1.6	-1.1	-1.1
Mood swings	1.0	1.7	5.8	1.0	-2.4	-0.8	-0.4	1.6	0.5	2.1	0.4	1.4	2.1	0.8	1.9	0.2	1.2	1.4	0.2	1.6	0.4
Bipolar Disorder (2011)	0.9	0.9	3.8	0.0	-1.9	0.3	-0.1	1.0	-0.2	1.3	0.8	0.9	1.3	0.8	0.8	1.1	0.8	1.2	1.0	0.0	1.1
Neuroticism	0.9	2.2	6.6	1.9	-2.6	-0.2	-0.7	1.6	1.5	1.9	1.0	1.4	2.4	1.2	1.3	0.9	1.1	1.5	0.7	1.9	0.9
Medication for hormone replacement therapy	0.9	1.0	2.5	-1.5	-0.8	1.0	1.2	-0.7	-1.3	-0.3	-0.8	-1.1	-1.6	-0.8	-0.8	-0.7	-1.2	-0.8	-0.7	-1.2	-0.6
Stomach or abdominal pain in last month	0.9	1.1	4.1	1.1	-0.2	-0.6	-0.3	1.2	-0.6	1.7	0.6	0.7	1.0	1.4	1.1	1.0	0.8	1.2	1.0	2.0	0.7
Neuroticism score	0.9	1.9	4.8	1.6	-1.3	-0.3	-0.8	1.8	0.7	0.8	1.3	1.5	2.2	1.6	1.5	1.3	1.1	1.7	1.1	1.8	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	4.2	1.7	-1.2	0.9	0.5	1.4	0.1	2.0	1.0	0.9	2.1	0.6	1.7	0.3	1.0	1.1	0.2	1.9	0.7
Glaucoma (self-reported)	0.9	1.0	3.8	-0.4	-0.5	1.9	-1.1	-1.1	-0.8	-0.9	-0.1	-0.9	-1.3	-1.1	-1.1	-0.8	-1.1	-0.9	-1.0	-0.7	-1.2
Qualifications: College or University degree	0.9	3.0	7.7	-1.0	0.3	0.3	2.5	-2.2	0.1	-1.4	-1.1	-2.8	-1.2	-2.0	-1.9	-1.3	-2.5	-2.6	-1.5	-1.7	-1.2
Medication: Blood pressure	0.9	1.6	7.3	0.9	-1.8	0.6	0.5	1.5	0.7	2.7	0.8	0.9	1.4	0.9	1.0	0.8	1.0	1.1	1.0	1.2	1.6
Medication: Allopurinol	0.9	1.2	2.4	-1.5	-0.9	-0.5	0.5	-1.2	-1.2	-0.9	-1.4	-1.5	-1.1	-0.6	-1.3	0.1	-1.4	-1.3	-0.6	-1.4	0.1
Leg fat mass (right)	0.9	3.6	7.8	-2.0	0.0	0.9	-0.1	-2.0	-0.9	-0.9	-2.3	-2.3	-0.7	-2.3	-1.7	-2.8	-2.1	-2.8	-2.7	-2.1	-1.8
Mineral and other dietary supplements	0.9	1.2	2.9	1.6	0.8	-1.0	-0.8	1.2	0.1	0.3	1.7	0.9	1.5	1.3	1.5	0.8	0.9	1.4	0.6	1.1	-0.2
Number of self-reported non-cancer illnesses	0.9	1.6	4.6	0.6	-2.2	-0.3	0.6	1.2	1.2	0.9	1.5	0.3	1.7	1.7	1.0	1.4	0.7	1.5	1.5	0.9	1.5
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	2.4	-1.5	0.2	-1.2	-0.6	-0.9	-0.8	-1.2	-1.2	-1.3	-1.1	-0.6	-1.0	-0.5	-1.5	-1.2	-1.2	-1.1	-1.0
Neuroticism (Nagel 2018)	0.8	1.9	5.6	2.1	-1.6	0.4	-0.9	1.2	1.9	1.7	1.0	1.4	2.4	0.8	1.1	0.4	1.3	1.0	0.4	1.8	0.8
Schizophrenia (2018)	0.8	1.6	3.7	1.4	1.6	1.2	-1.6	0.7	0.8	0.5	-0.6	1.6	-0.8	0.9	1.7	0.6	1.9	0.8	1.8	1.4	1.0
Irritable Bowel Disease (IBD)	0.8	1.8	7.1	-1.0	-0.4	-2.7	-1.8	-1.0	0.9	-0.5	-1.3	-0.9	-1.4	-1.4	-1.9	-1.2	-1.1	-1.0	-1.3	-1.4	-1.2
Lupus	0.8	1.2	5.7	0.4	0.2	-1.0	-2.4	0.3	1.4	0.3	-0.3	0.8	-1.2	1.4	1.1	1.4	0.7	0.8	1.5	1.1	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.9	0.7	0.1	-0.5	-1.5	1.5	-0.1	0.8	1.7	1.2	1.7	0.4	0.9	0.8	1.1	1.1	0.2	1.0	1.2
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	2.3	1.0	-0.1	-0.9	-1.2	0.7	0.8	0.9	0.5	0.8	1.2	0.9	0.3	1.0	0.8	0.7	1.5	0.7	1.1
Medication: Levothyroxine sodium	0.8	1.3	3.4	0.6	-0.8	-0.1	0.0	1.6	1.5	0.4	1.8	1.0	1.0	1.5	1.1	1.5	0.7	1.8	1.4	0.8	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	3.5	1.9	-0.2	-0.7	-1.1	0.9	1.6	0.7	1.1	1.3	1.5	0.5	1.5	0.4	1.5	0.9	1.0	1.5	0.6
Qualifications: None of the above	0.8	1.6	4.5	0.4	0.5	-0.3	-2.1	1.4	-0.5	-0.2	0.9	1.5	1.5	1.2	1.4	0.9	2.0	1.2	1.5	1.2	1.8
Medication: Ramipril	0.8	1.0	5.3	-1.1	-2.3	-0.4	1.3	1.2	-0.1	1.2	0.6	0.3	0.2	0.6	0.5	0.5	0.3	1.5	1.0	0.7	1.1
Time employed in main current job	0.8	0.9	3.1	-0.8	1.8	1.7	0.4	-0.6	-1.6	-0.8	-0.7	-0.5	-0.1	-0.7	-0.7	-1.6	0.4	-0.5	-0.7	-0.4	-0.5
Falls in the last year	0.8	1.1	2.7	1.2	-0.7	1.6	-1.3	0.9	0.9	1.6	0.7	0.5	0.7	0.3	1.4	0.1	1.3	0.6	1.5	1.0	1.3
Pulse rate	0.8	1.4	16.4	0.0	-0.1	-4.0	-0.6	0.7	-0.0	0.0	1.1	-0.6	1.5	0.8	0.4	0.7	-0.8	0.9	0.1	0.4	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	6.4	0.0	-0.5	1.4	-2.5	-0.8	-0.4	-0.2	-0.7	-0.1	-0.9	-1.2	-0.6	-1.0	-0.5	-0.9	-1.5	-0.2	-0.6
Tense / ‘highly strung’	0.8	1.3	6.6	1.0	-0.7	0.0	-0.6	1.1	1.1	1.4	0.2	1.1	2.6	1.1	0.3	1.0	1.2	1.1	1.2	1.1	1.2
High blood pressure (siblings)	0.8	1.2	3.4	-1.2	-1.8	0.9	-0.8	-1.0	0.6	0.9	-1.3	-1.0	0.5	-1.3	-1.0	-1.7	-0.7	-0.8	-1.7	-0.7	-0.5
Eye problems/disorders: None of the above	0.8	0.9	3.0	-0.6	1.6	-1.7	0.7	-0.6	1.7	-1.0	-0.4	-0.1	-0.5	-0.9	-0.3	-1.1	-0.3	-0.5	-1.3	-0.9	-0.9
Family relationship satisfaction	0.8	1.0	5.1	-0.9	-2.3	0.5	-0.3	-1.0	-0.3	0.6	-1.5	-1.0	-0.9	-0.6	-1.2	-0.3	-1.4	-1.0	-1.0	-0.4	-0.6
Commuting to job workplace: Walk	0.8	0.9	3.1	0.3	-1.5	0.6	-0.6	1.0	0.6	1.2	0.6	0.9	0.5	0.7	1.1	1.1	0.8	0.7	1.0	0.6	1.8
Osteoporosis (self-reported)	0.8	0.9	3.2	0.5	-1.5	-1.8	0.9	1.3	0.6	-0.3	0.5	0.6	0.9	1.1	1.1	0.5	0.3	1.6	0.4	1.1	-0.3
Medication: Gliclazide	0.8	0.9	2.6	-1.1	0.7	0.7	-0.5	-0.9	-1.6	-1.2	-1.6	-0.8	-0.9	-0.9	-1.0	-0.5	-1.2	-0.8	-0.7	-0.4	-0.8
Commuting to job workplace: Public transport	0.8	1.0	3.3	1.7	-0.1	0.1	0.0	0.9	1.8	1.0	1.0	0.9	1.5	0.4	1.4	-0.0	1.2	0.6	0.1	1.3	0.4
Medication: Blood pressure	0.8	1.6	6.5	0.7	-2.5	-0.3	1.9	1.2	0.6	2.4	1.5	1.0	1.4	0.5	0.6	0.5	0.8	1.4	0.4	1.0	0.6
Leg fat mass (left)	0.8	3.1	6.9	-1.9	0.1	1.0	-0.1	-1.8	-0.9	-0.8	-2.2	-2.1	-0.7	-2.1	-1.6	-2.6	-1.9	-2.6	-2.5	-2.1	-1.6
Alzheimer’s Disease (in mother)	0.7	0.9	2.4	-1.2	-0.3	-0.9	1.5	-0.9	-1.1	-0.3	-0.3	-1.0	0.1	-0.8	-1.4	-0.8	-1.0	-1.0	-0.7	-1.5	-0.2
Ovarian Cancer	0.7	1.0	4.0	2.0	-0.3	0.3	1.0	0.8	-0.7	0.4	1.3	0.8	1.7	0.4	1.3	0.5	0.8	0.7	0.3	1.5	-0.0
Prostate Cancer	0.7	1.0	3.0	-1.7	0.3	-0.2	-0.1	-0.7	-1.3	-1.6	-0.8	-0.6	-0.8	-1.0	-1.3	-1.3	-0.3	-0.7	-1.0	-1.4	-0.4
Blood Platelet Count	0.7	8.1	14.4	-3.0	-0.6	1.4	1.8	-3.4	-3.8	-2.5	-2.9	-3.6	-1.1	-3.4	-3.0	-3.6	-2.9	-3.6	-2.8	-3.1	-2.1
Vitamin and mineral supplements	0.7	1.0	3.0	0.8	-0.2	-0.3	0.5	1.2	-0.5	1.1	1.6	1.5	1.7	0.8	0.9	0.7	1.0	1.5	0.0	0.9	0.4
Medication: Metformin	0.7	1.0	2.2	-0.7	0.5	-1.4	-0.2	-0.7	1.0	-1.0	-0.3	-1.3	0.4	-0.5	-1.3	-0.9	-1.4	-0.5	-0.9	-1.4	-1.5
Impedance of leg (right)	0.7	3.4	9.9	2.4	0.3	0.6	-0.1	1.5	2.1	1.9	3.1	1.4	2.3	2.0	0.8	2.9	0.9	1.7	2.1	2.1	1.6
Happiness	0.7	0.8	2.8	-0.3	-0.4	0.2	0.7	-0.7	0.8	0.3	-1.7	-1.0	-0.6	-1.2	-0.5	-1.1	-1.1	-1.2	-1.5	-0.0	-1.0
Prospective memory result	0.7	0.9	3.0	-0.6	-1.1	1.7	1.7	-0.7	-1.1	-0.6	-0.4	-0.8	-0.1	-0.7	-0.7	-0.9	-0.8	-0.3	-0.7	-0.7	-1.3
Mouth/teeth dental problems: Loose teeth	0.7	0.8	2.4	0.6	-0.7	-0.5	-0.7	0.5	-1.3	0.7	-0.1	0.4	1.1	1.0	0.8	1.1	0.9	0.4	1.5	0.5	1.5
Medication: Ibuprofen	0.7	0.8	1.9	-0.1	0.3	1.1	-1.4	-1.1	-0.7	-0.3	-1.4	-1.1	-1.1	-1.2	-0.5	-0.9	-0.7	-1.2	-0.7	-0.3	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.0	0.5	1.2	-1.4	-0.7	-1.2	0.5	-1.3	-0.2	-0.7	-1.3	-0.7	-0.4	-0.7	-0.6	-0.5	-0.1	-0.9	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	4.2	0.5	-0.9	0.9	1.6	-0.2	-0.3	1.4	-0.2	-0.3	0.4	-1.1	0.5	-2.0	0.3	-0.3	-0.9	-0.1	-0.7
Heart attack/myocardial infarction (self-reported)	0.7	0.9	4.9	-0.7	1.0	0.0	-0.9	-0.8	0.4	0.3	-0.3	-0.3	-0.7	-1.4	-1.4	-2.2	0.1	-0.8	-1.4	-1.0	-0.3
Bipolar Disorder or Schizophrenia	0.6	1.5	4.1	1.4	1.4	1.2	-1.9	0.8	0.5	0.8	0.2	1.5	0.4	0.6	1.5	0.2	2.0	0.8	1.5	1.4	1.4
Intelligence (Savage-Jansen 2018)	0.6	1.7	6.7	-0.5	-0.1	-2.6	-1.5	-1.3	0.7	-0.2	-1.0	-1.3	-0.7	-1.6	-1.2	-1.9	-1.1	-1.5	-1.4	-1.2	-1.0
Verbal and Numeric Reasoning (VNR)	0.6	1.5	8.4	-0.3	0.0	-2.9	-2.2	-0.9	0.2	-0.6	-0.7	-1.0	-0.6	-1.2	-0.6	-1.2	-1.2	-0.7	-1.5	-0.6	-1.7
Townsend deprivation index at recruitment	0.6	0.9	2.3	0.5	-0.6	-0.7	0.1	1.3	0.2	0.6	1.2	1.2	0.9	0.9	1.4	0.6	1.2	1.5	1.0	0.9	0.5
Impedance of leg (left)	0.6	2.9	9.2	2.0	0.8	0.5	-0.3	1.4	1.4	1.6	3.0	1.4	2.1	1.9	0.5	2.7	1.0	1.6	2.0	1.8	1.6
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.2	1.3	-0.2	0.7	1.5	0.9	0.9	0.8	0.8	1.2	0.9	0.4	0.6	0.6	0.9	0.7	0.3	0.8	0.5
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.0	0.2	-1.1	0.5	1.2	-1.1	-1.2	-0.4	-0.6	-1.1	-0.7	-0.8	0.0	-0.9	-1.0	-1.0	-0.7	-0.6	-1.4
Weight	0.6	3.1	6.2	-1.6	-0.5	0.6	0.5	-1.7	-1.4	-0.8	-2.1	-2.3	-1.6	-1.9	-1.3	-2.3	-2.3	-2.5	-2.3	-1.9	-1.9
Number of live births	0.6	0.8	3.2	-0.5	1.8	-0.2	-0.1	-1.0	-0.6	-1.5	-0.5	-1.0	-0.3	-0.9	-0.6	-0.9	-0.9	-0.8	-0.5	-1.0	-1.3
Blood clot in the leg (DVT)	0.6	0.8	1.9	-1.2	-0.1	-1.2	-0.9	-0.7	-0.8	-1.0	-0.8	-1.2	-0.8	-0.3	-0.8	-0.3	-1.4	-1.0	-1.0	-0.9	-0.8
Number of full brothers	0.6	0.8	4.6	-0.2	-1.9	2.1	-0.3	-0.4	-1.3	0.7	-1.2	-0.1	-1.1	-0.3	0.3	-0.6	0.3	-0.5	0.0	0.1	0.4
Medication for pain relief, constipation, heartburn	0.6	1.1	3.3	-1.2	-0.2	-0.9	1.0	-0.6	0.8	-1.2	-0.6	-0.6	-1.1	-0.8	-0.7	-1.0	-1.2	-0.3	-1.8	-1.2	-1.8
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.9	0.1	0.7	-0.2	-1.7	-0.7	-1.6	-0.5	-1.1	-0.6	-0.5	-0.6	-0.5	-0.7	-0.6	-0.4	-0.6	-0.2	-1.3
Medication: Aspirin	0.6	0.8	2.0	0.7	-0.4	-0.4	0.0	1.1	1.0	1.1	1.3	0.9	1.4	1.0	0.3	0.5	1.1	1.0	1.1	0.5	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.3	1.2	0.3	-0.5	1.1	0.5	-0.6	1.5	0.7	0.6	1.3	1.0	0.5	0.8	0.8	0.3	0.3	0.8	1.1
Illnesses of siblings: Diabetes	0.6	0.7	2.9	0.5	1.7	1.2	-0.4	0.4	0.6	-0.5	0.9	0.9	0.3	0.3	0.1	0.4	1.3	0.2	1.2	0.3	1.3
Qualifications: nursing, teaching	0.6	1.0	6.8	-0.0	2.6	0.4	-0.2	-0.8	1.2	-0.9	0.1	-0.5	-1.9	-0.0	-1.0	0.6	-0.8	-0.9	0.4	-0.6	0.3
Number of operations (self-reported)	0.6	0.8	5.5	0.7	-0.9	-0.8	-2.3	0.2	1.9	0.9	0.6	0.2	1.0	0.1	0.3	0.4	0.2	0.1	0.1	0.6	1.0
Average weekly beer plus cider intake	0.6	0.9	2.8	0.4	0.5	-0.2	-1.0	1.4	-1.3	-0.1	1.7	0.8	1.0	1.0	0.7	0.7	0.8	1.2	0.4	1.0	0.7
Commuting to job workplace: Cycle	0.6	0.8	3.5	0.8	0.1	-0.5	-0.1	0.7	0.7	0.2	1.9	0.6	0.8	0.8	0.5	1.7	0.3	0.3	0.9	0.2	1.5
Basal cell carcinoma (self-reported)	0.6	0.7	3.4	-0.2	-1.4	0.1	-0.9	0.4	1.9	1.5	0.4	-0.0	0.6	0.6	0.2	0.7	0.2	0.7	0.5	0.6	0.8
Pack years of smoking	0.6	0.8	5.2	1.0	2.3	0.2	-1.4	0.5	-0.1	0.7	0.3	0.8	1.4	0.2	0.1	-0.1	1.1	-0.2	0.5	0.6	1.1
Coronary Artery Disease (CAD)	0.5	0.6	6.7	0.6	-0.7	-2.6	-1.3	0.2	0.1	-0.1	-0.1	0.2	-0.0	0.1	0.7	0.5	-0.1	0.5	0.1	0.6	-0.1
HbA1C	0.5	0.5	2.7	1.0	-0.1	-0.0	-1.4	0.2	-0.8	0.2	-1.0	0.8	-1.6	0.4	0.2	0.4	0.6	0.0	0.1	0.6	0.3
Hypothyroidism (self reported)	0.5	1.0	3.9	0.8	-0.8	0.3	1.1	1.6	0.6	0.7	0.4	1.2	0.5	1.0	1.5	1.1	0.4	2.0	0.9	1.3	-0.6
Respiratory disease	0.5	1.2	3.9	0.9	-1.5	0.9	0.3	1.4	-0.4	2.0	1.5	0.1	1.3	1.0	1.6	0.3	0.5	1.4	0.8	1.1	0.2
Pack years adult smoking proportion	0.5	0.8	3.7	1.2	1.9	0.4	-1.1	0.5	-0.5	0.9	0.3	0.8	1.3	0.4	0.0	0.1	1.2	-0.2	0.8	0.8	1.2
Leg fat-free mass (left)	0.5	2.7	6.1	-1.4	-0.9	-0.5	0.6	-1.3	-1.4	-1.1	-1.7	-2.0	-1.7	-1.7	-0.9	-2.3	-2.2	-1.7	-2.5	-1.5	-2.4
Multivitamins +/- minerals	0.5	0.6	1.7	-0.2	-0.8	0.5	-1.2	-0.8	0.5	-0.1	-0.9	-1.2	-0.9	-0.6	-0.6	-0.2	-1.2	-1.3	-0.3	-0.6	-0.2
Leg predicted mass (left)	0.5	2.7	6.0	-1.4	-0.9	-0.5	0.6	-1.3	-1.3	-1.1	-1.7	-2.0	-1.7	-1.6	-0.8	-2.3	-2.2	-1.7	-2.5	-1.5	-2.4
Waist circumference	0.5	1.8	3.6	-1.4	-0.2	0.5	-0.6	-1.2	-1.5	-0.4	-1.7	-1.8	-1.1	-1.5	-0.8	-1.8	-1.5	-1.9	-1.6	-1.5	-1.1
Heart attack	0.5	0.6	3.7	-0.6	1.0	0.2	-0.6	-0.7	0.2	0.4	-0.3	-0.2	-0.6	-1.1	-1.2	-1.9	0.3	-0.6	-1.1	-0.8	-0.0
Pain all over the body in last month	0.5	0.6	2.2	0.9	-0.5	-0.1	0.6	0.9	0.2	0.4	1.5	0.4	1.2	0.5	0.7	-0.5	1.2	0.8	0.8	0.2	0.5
Medication: Cholesterol lowering	0.5	0.8	4.0	-0.1	0.3	-1.6	-1.8	-0.3	2.0	0.8	0.3	-0.6	0.9	-0.3	-0.6	-0.4	-0.2	-0.5	-0.2	-0.5	0.7
Lung cancer (father)	0.5	0.6	3.1	0.8	1.7	1.0	-1.8	0.4	0.0	0.4	0.5	0.6	0.7	0.4	0.3	0.1	0.8	0.0	0.4	0.5	0.7
Pulse wave Arterial Stiffness index	0.5	0.6	3.9	-1.5	-0.5	-0.2	-2.0	-0.4	-0.6	-0.2	0.0	-0.6	-0.7	0.7	-0.6	1.1	-0.9	0.1	0.3	-0.6	0.1
Birth weight of first child	0.5	1.0	3.1	1.1	-0.4	1.8	1.5	0.5	0.2	0.5	1.0	1.1	0.6	0.7	1.0	0.8	1.1	0.6	1.3	1.0	1.1
Medication: Paracetamol	0.5	0.8	2.1	-0.6	1.4	1.4	-1.2	-1.1	-1.2	-1.4	-0.7	-0.6	-0.9	-0.5	-1.0	-0.3	-0.2	-1.0	0.2	-0.5	0.4
Chronic bronchitis/emphysema (mother)	0.5	0.6	3.3	-0.1	-0.9	-1.8	0.7	0.9	-0.4	0.4	-0.1	0.7	0.6	1.0	0.6	0.5	0.4	1.3	0.8	0.6	-0.1
Leg fat percentage (right)	0.5	1.9	5.9	-1.1	-0.0	1.4	-0.5	-1.5	-0.4	-0.1	-1.6	-1.5	0.1	-1.9	-1.4	-2.1	-1.3	-2.4	-1.9	-1.5	-0.8
Comparative body size at age 10	0.5	1.4	4.7	-1.6	0.4	0.5	-1.2	-0.9	-1.3	-1.4	-0.4	-1.0	-0.2	-1.3	-2.2	-1.5	-0.5	-1.0	-0.8	-2.2	-0.7
Wheeze or whistling in the chest in last year	0.5	1.0	6.2	0.2	-1.0	1.1	-2.5	0.6	-0.3	1.4	-0.4	0.5	0.6	-0.1	0.7	-0.4	1.4	0.4	1.0	0.9	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	3.4	-0.7	-1.2	0.9	-1.1	0.4	-1.0	0.7	0.8	-0.3	1.8	0.0	-0.1	0.7	-0.4	0.4	0.1	-0.3	0.8
Health satisfaction	0.5	0.6	2.5	0.7	-0.7	0.4	1.3	0.8	-0.1	1.4	-0.2	0.6	1.6	0.6	0.8	0.4	0.8	0.0	0.6	0.7	1.0
Number of full sisters	0.5	0.6	1.8	-0.7	-0.3	0.4	-0.2	-0.5	-0.1	0.7	-1.3	-1.3	-0.5	-1.1	0.0	-1.2	-0.7	-1.0	-0.9	-0.2	-0.4
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	2.0	-1.0	1.4	-1.2	0.3	-0.6	-1.3	-1.3	-0.3	-0.1	-1.0	0.2	-0.4	0.4	-0.0	-0.1	0.4	-0.9	0.2
Leg fat-free mass (right)	0.5	2.6	5.6	-1.4	-0.8	-0.6	0.4	-1.2	-1.7	-1.1	-1.6	-1.8	-1.9	-1.6	-0.9	-2.2	-2.0	-1.6	-2.4	-1.5	-2.3
Loneliness, isolation	0.5	0.7	2.9	0.2	-0.6	1.0	-1.6	0.6	1.7	1.3	1.0	0.6	0.6	0.4	0.0	0.3	0.4	0.6	0.4	0.3	0.5
Medication for cholesterol	0.5	0.7	3.9	1.0	1.5	-0.2	-2.0	0.2	-0.2	-0.8	0.3	0.7	-0.7	0.9	1.0	0.7	0.8	0.1	0.7	0.3	0.4
Smoking status: Current	0.5	0.7	5.3	0.5	0.9	2.3	-0.0	-0.5	-1.8	0.1	-0.0	-0.2	0.7	-0.6	-0.9	-0.1	0.1	-0.9	0.3	-0.0	0.8
Leg predicted mass (right)	0.5	2.8	6.0	-1.5	-0.7	-0.6	0.3	-1.3	-1.8	-1.2	-1.7	-1.9	-2.0	-1.7	-1.0	-2.3	-2.1	-1.7	-2.5	-1.6	-2.4
Leg fat percentage (left)	0.5	1.9	5.7	-1.3	0.3	1.5	-0.6	-1.4	-0.6	-0.2	-1.7	-1.4	0.1	-1.9	-1.4	-2.0	-1.2	-2.4	-1.9	-1.6	-0.7
Age started oral contraceptive pill	0.5	0.6	1.4	-1.0	0.6	-0.9	-0.2	-0.4	0.5	-1.0	-0.3	-0.7	-0.4	-1.1	-0.4	-0.8	-0.7	-0.4	-1.0	-1.2	-0.8
Ever depressed for a whole week	0.5	0.6	2.9	0.5	-0.7	1.5	-0.1	0.5	1.7	1.4	0.3	0.8	0.6	0.2	0.9	0.3	0.6	0.8	-0.0	0.6	0.6
Crohns Disease (2012)	0.4	0.6	1.8	1.1	0.3	-0.7	-0.7	0.6	0.8	0.6	0.4	1.3	-0.1	0.5	0.2	0.8	1.4	0.7	0.9	0.6	1.1
Fasting Glucose	0.4	0.5	2.0	-0.2	0.6	-0.0	-1.3	-0.8	0.5	-0.5	0.3	-0.8	1.4	-0.3	-0.5	-0.6	0.1	-0.7	0.1	-1.1	0.5
Schizophrenia (2014)	0.4	1.0	5.3	0.2	2.3	2.0	-1.1	-0.3	0.1	-0.7	-1.5	0.6	-1.2	-0.2	0.4	-0.5	1.0	-0.3	0.7	0.2	0.4
Type 2 Diabetes (T2D) (2018)	0.4	0.8	3.2	-0.3	0.9	-1.3	0.3	-1.0	0.8	-0.8	0.2	-0.7	0.8	-0.3	-1.7	-0.3	-0.7	-0.6	0.1	-1.8	-0.6
Hand grip strength (left)	0.4	1.0	8.6	0.1	-0.7	0.3	2.9	-0.5	-1.2	-1.2	0.4	-0.4	-0.4	-0.4	-1.0	-0.4	-0.8	-0.2	-0.8	-0.5	-1.3
Taking other prescription medications	0.4	0.6	5.0	0.2	-2.2	-0.4	0.0	0.1	-1.8	0.5	-0.1	-0.7	1.0	0.0	-0.4	-0.1	-0.4	0.0	0.1	0.3	0.3
High blood pressure (mother)	0.4	0.6	2.9	0.4	-1.7	0.3	0.2	0.5	-0.3	1.5	-0.0	-0.2	0.2	-0.2	0.7	-0.6	-0.1	1.1	-0.6	1.1	-1.0
Had menopause	0.4	0.5	1.9	0.3	-1.2	0.6	0.0	0.4	1.0	0.8	-0.3	0.7	-0.3	-0.0	1.1	-0.5	1.4	0.3	0.4	0.8	0.7
Diabetes (self-reported)	0.4	0.6	3.9	0.4	0.7	-0.3	-0.5	0.3	1.4	0.2	1.1	0.1	2.0	0.8	-0.5	0.7	0.2	0.6	1.1	-0.2	0.4
Medication: Simvastatin	0.4	0.5	2.8	-0.4	-0.3	-1.7	-0.7	0.1	1.5	0.4	0.6	-0.6	1.1	0.2	-0.6	0.4	-0.7	-0.1	-0.0	-0.7	0.5
Illnesses of siblings	0.4	0.6	1.6	0.7	0.9	-1.3	1.3	0.5	-0.5	-0.1	0.6	0.7	-0.9	0.9	0.5	0.8	0.3	0.8	0.6	0.3	-0.6
Mouth/teeth dental problems: Dentures	0.4	0.7	2.8	1.3	0.3	-0.1	-0.6	0.4	0.2	0.2	1.3	0.9	1.2	0.1	-0.1	0.5	1.3	-0.0	1.1	0.1	1.7
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.5	0.1	0.1	1.0	-1.2	-0.7	-0.8	0.3	-1.2	-0.7	-0.9	-0.8	-0.1	-0.6	-0.5	-1.0	-0.6	0.2	-0.5
Length of working week for main job	0.4	0.5	3.2	-1.0	-0.1	1.8	-0.4	0.1	-1.1	0.2	-0.4	-0.1	1.3	0.2	-0.3	0.4	-0.2	-0.3	0.1	-0.4	0.6
Hair/balding pattern: Pattern 4	0.4	1.0	4.9	-0.4	0.7	-2.2	1.1	1.1	0.9	-0.4	1.4	1.3	0.5	1.1	0.1	1.2	0.3	1.7	0.2	-0.1	-0.2
Loud music exposure frequency	0.4	0.5	3.3	-0.1	0.0	-1.8	-0.3	0.7	-0.5	0.7	0.7	0.0	1.1	0.9	0.1	0.3	0.3	0.9	0.7	0.4	0.3
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	4.4	-0.3	-1.0	-2.1	1.4	0.3	-0.5	-0.4	0.1	-0.5	-0.4	-0.2	0.2	0.3	-1.4	0.1	-1.1	-0.1	-1.3
Headache pain in last month	0.4	0.7	2.7	-0.7	-0.4	0.2	-0.3	-1.0	-1.2	-0.6	-1.6	-1.2	-1.0	-0.7	-0.4	-0.1	-1.3	-0.8	-0.3	-0.4	-1.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.6	0.4	-0.9	0.2	-0.1	1.2	1.2	0.5	0.8	0.8	0.8	1.1	0.8	1.3	0.4	1.6	1.4	0.9	0.3
Medication: Amlodipine	0.4	0.6	3.1	0.4	0.1	-1.8	-0.2	0.9	0.9	0.8	0.4	0.9	1.5	0.5	-0.2	0.4	0.7	0.6	-0.1	0.7	0.6
Exposure to tobacco smoke outside home	0.4	0.6	3.3	-0.3	-1.0	0.7	-1.8	0.4	-1.1	-0.2	0.3	0.2	0.2	0.7	0.4	0.9	-0.0	1.0	0.9	0.7	0.2
Worry too long after embarrassment	0.4	0.7	4.3	0.6	2.1	0.7	-0.4	0.4	0.9	0.1	0.3	0.8	0.4	0.5	-0.3	0.9	0.8	-0.4	0.6	0.3	1.6
Pulse wave peak to peak time	0.4	0.5	3.5	1.4	0.3	-0.0	1.9	0.3	0.7	0.2	0.2	0.3	0.6	-0.8	0.4	-1.2	0.6	-0.1	-0.4	0.4	-0.3
Medication: Seretide 50 evohaler	0.4	0.4	1.5	-0.3	-0.6	-1.1	0.4	-0.5	-0.1	-0.7	0.0	-0.8	-0.8	-0.4	-0.4	-0.2	-1.2	-0.2	-0.5	-0.7	-1.0
Mean time to correctly identify matches	0.4	0.7	2.2	-1.3	1.5	1.2	0.4	-1.3	-0.6	-1.0	-0.9	-0.9	-0.6	-0.7	-0.4	-0.7	-0.3	-1.0	0.0	-0.8	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	2.4	0.5	-1.6	-0.7	0.3	0.3	-0.3	0.5	0.4	0.5	0.7	0.7	0.7	1.0	0.2	0.4	0.7	0.6	0.7
Pulse rate, automated reading	0.4	1.3	10.7	-0.4	-0.2	-3.3	1.0	0.5	-1.3	-0.7	-0.7	-0.6	1.7	0.7	0.8	0.5	-1.1	0.9	-0.3	0.9	-1.2
Chest pain or discomfort	0.4	0.6	3.0	1.0	-0.5	0.7	-1.7	0.1	1.1	1.2	0.5	0.2	0.8	0.3	-0.1	0.5	0.5	0.2	0.7	0.2	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	2.0	0.4	-1.4	-0.8	-0.6	0.7	-0.7	1.3	-0.3	0.5	0.4	0.3	0.4	-0.1	0.7	0.7	0.1	1.0	-0.0
Supplements: Vitamin C	0.4	0.5	1.7	-0.2	-0.5	-0.4	1.0	-0.8	-1.0	-0.9	-1.0	-0.7	-1.3	-0.6	-0.4	-0.9	-0.1	-0.7	0.3	-0.5	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	3.0	1.7	0.2	0.1	0.9	0.9	0.0	0.4	1.2	0.7	-0.5	1.3	0.9	1.7	0.2	0.6	1.2	1.3	0.2
Average weekly red wine intake	0.4	0.6	2.6	-0.1	1.1	-0.6	0.9	-0.5	0.7	-1.6	0.6	-0.6	-1.2	0.8	-0.5	1.0	-0.7	-0.2	0.6	-0.9	0.3
Eye problems/disorders: Cataract	0.4	0.5	1.7	0.7	-0.8	1.1	-1.0	0.4	-0.3	1.1	0.2	0.3	0.5	0.6	0.4	0.6	0.6	0.4	1.3	0.7	0.8
Breast cancer (self-reported)	0.4	0.4	1.8	1.2	-0.7	-0.6	1.4	-0.6	-0.0	-0.2	-1.0	-0.3	-0.4	-0.4	0.2	-0.6	-0.3	-0.6	-0.2	0.5	-0.9
Medication: Aspirin	0.4	0.5	1.3	0.6	-0.3	-0.6	-0.1	0.9	0.6	0.7	1.0	0.6	1.1	0.9	0.2	0.5	0.8	0.7	0.8	0.4	1.1
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.9	0.9	-1.4	0.8	-0.1	-0.4	0.6	0.4	-1.1	0.7	-0.1	0.1	1.0	0.1	0.6	0.2	0.4	0.9	0.3
Diastolic blood pressure, automated reading	0.4	1.3	8.4	-0.3	-2.9	0.3	0.5	1.2	0.2	2.3	0.2	0.3	0.1	0.9	1.1	1.1	-0.1	1.7	0.5	0.7	0.1
Unable to work because of sickness or disability	0.4	0.5	1.9	0.6	0.2	-0.1	-1.0	0.4	-0.6	0.6	1.1	0.6	0.4	0.4	0.0	0.5	0.9	0.2	0.9	0.6	1.4
Myopia	0.4	0.6	3.4	0.1	-1.8	1.2	0.8	-0.4	-0.1	0.5	-1.0	-0.7	-0.3	-0.8	0.3	-0.8	-0.5	-0.0	-0.7	0.8	-1.2
Alcohol drinker status: Previous	0.4	0.5	1.7	-0.4	0.8	-1.3	-1.2	-0.5	-0.7	-0.0	-0.8	-0.9	0.1	-0.6	-0.7	-0.7	-0.3	-0.5	-0.2	-0.1	-0.5
Bipolar Disorder (2018)	0.3	0.5	2.4	0.4	0.4	0.5	-1.0	0.5	-0.1	0.6	1.1	0.4	1.6	-0.3	0.3	-0.4	0.9	0.4	0.1	0.5	0.9
Schizophrenia vs Biploar Disorder	0.3	0.4	2.3	0.0	-0.1	0.6	0.6	0.4	-1.5	0.5	-1.2	0.4	-1.5	0.2	0.4	-0.0	0.2	0.0	0.1	0.0	-0.3
Crohns Disease (2017)	0.3	0.7	6.3	-0.1	0.1	-1.2	-2.5	0.2	1.0	0.5	0.3	0.7	-0.2	-0.4	-1.1	-0.2	0.7	0.1	-0.1	-0.3	0.7
HDL Cholesterol	0.3	0.5	2.0	-1.4	-0.3	0.9	0.3	-0.3	-1.3	-0.7	-0.5	-0.3	-0.5	-0.3	-1.2	0.1	-0.5	-0.5	0.1	-1.0	-0.1
Rheumatoid Arthritis	0.3	0.4	2.5	-0.6	0.8	1.1	0.3	-0.4	-1.0	-0.4	-0.7	0.0	-1.6	-0.1	0.1	-0.2	-0.3	-0.2	-0.2	-0.2	-0.7
Heel T-Score	0.3	2.4	8.1	2.0	0.8	2.1	-1.2	0.2	1.7	2.6	0.0	1.8	0.2	1.0	-0.0	0.8	2.7	-0.4	1.1	1.4	2.8
Chronotype (morning person)	0.3	0.7	2.3	0.9	1.2	-0.8	-1.4	0.6	0.1	-0.3	0.7	1.5	1.1	0.4	0.5	-0.2	1.2	0.8	0.1	0.7	-0.2
Sensitivity / hurt feelings	0.3	0.5	1.3	0.5	-0.3	1.1	-0.9	-0.8	0.1	-0.7	-0.9	-0.1	0.3	-0.7	-0.4	-0.7	-0.5	-1.1	-1.0	0.2	-0.6
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.9	0.5	-1.4	0.3	0.1	0.5	-0.0	0.9	0.4	0.5	0.6	0.3	1.1	-0.3	0.8	0.3	0.3	0.4	0.6
Ever had hysterectomy (womb removed)	0.3	0.4	1.2	0.4	-0.7	0.2	1.1	0.5	0.3	-0.4	0.7	0.4	0.3	0.6	1.1	0.5	0.4	0.8	0.5	0.5	0.5
Angina	0.3	0.5	1.8	-0.8	-0.8	-1.3	-0.1	-0.4	-0.2	0.4	0.3	-1.0	-0.5	-0.7	-1.0	-0.6	-0.7	-0.4	-0.6	-0.7	-0.4
Supplements: Zinc	0.3	0.4	3.8	-0.0	-0.4	-0.3	0.5	-0.4	1.9	-0.2	0.3	-0.0	0.2	-0.1	-1.3	0.0	-0.4	0.1	-0.3	-0.5	-0.3
Hand grip strength (right)	0.3	0.9	12.1	0.6	-0.7	0.4	3.5	0.0	-0.7	-0.1	1.0	-0.2	0.6	-0.1	-0.7	-0.2	-0.4	0.1	-0.3	0.1	-0.8
Current tobacco smoking	0.3	0.6	3.8	0.4	0.6	1.7	-0.2	-0.6	-1.9	0.1	-0.0	-0.2	0.4	-0.6	-0.8	-0.1	-0.1	-0.9	0.1	-0.0	0.6
Maternal smoking around birth	0.3	0.4	1.1	-0.5	-0.8	0.1	-1.1	0.8	-1.0	0.4	0.4	0.5	1.0	0.6	0.6	0.3	0.4	1.0	0.4	0.3	0.1
Age when periods started (menarche)	0.3	0.6	2.1	1.4	-0.8	0.5	1.3	0.3	-1.0	0.7	1.3	0.1	-0.3	0.3	0.8	0.6	0.6	0.2	0.8	0.6	0.8
Qualifications: CSEs or equivalent	0.3	0.4	1.4	0.0	0.6	-1.0	0.0	-0.7	0.9	-0.9	0.1	-0.0	-1.2	-0.2	-1.0	-0.2	-0.0	-0.3	-0.4	-0.5	-0.6
Supplements: Glucosamine	0.3	0.4	1.1	-0.7	-1.0	0.9	0.6	-0.5	-0.9	-0.0	-0.7	-0.3	-0.9	-0.4	-0.5	-0.2	-0.4	-0.5	-0.8	-0.3	0.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.3	-1.1	-0.3	-0.9	-0.1	-0.2	-0.0	-0.7	-1.1	-0.3	-0.1	-0.7	-0.4	-0.8	-0.4	-0.1	-0.4	-0.4	-0.4
Past tobacco smoking	0.3	0.6	1.5	0.8	-0.4	0.6	1.0	0.6	0.1	0.2	0.5	1.2	-1.0	0.6	1.1	0.2	1.1	1.2	0.8	0.5	-0.2
Hair/balding pattern: Pattern 2	0.3	0.4	2.2	-0.1	-0.9	1.5	0.6	-0.6	-1.1	-0.4	-0.3	-1.0	-0.4	0.1	-0.4	-0.5	-0.4	-0.2	0.5	-0.2	-0.3
Had other major operations	0.3	0.4	2.0	1.1	-0.2	0.3	-1.4	-0.1	1.4	0.2	-0.1	0.1	0.2	-0.1	0.5	0.0	0.3	-0.1	0.0	0.7	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	2.5	-0.1	0.8	1.6	-1.4	-0.7	1.2	-0.2	-0.6	0.3	-1.2	-0.1	-1.2	-0.2	0.7	-0.4	-0.0	-0.4	0.7
Worrier / anxious feelings	0.3	0.5	2.5	1.5	-1.1	1.6	-0.0	0.7	0.3	0.7	0.1	0.4	0.8	0.3	0.5	0.4	0.0	0.2	-0.0	1.0	0.1
Illnesses of mother	0.3	0.4	3.3	0.5	0.6	0.4	-1.8	0.3	0.5	-0.0	0.0	0.7	0.0	0.6	0.3	0.9	0.4	-0.1	0.7	0.4	0.8
Exposure to tobacco smoke at home	0.3	0.3	1.8	-1.3	0.1	-1.0	-0.1	-0.0	-1.0	-0.2	-0.6	-0.7	0.0	0.0	-0.5	-0.2	-0.4	-0.1	0.2	-0.3	0.3
Breastfed as a baby	0.3	0.4	3.3	-0.0	1.8	-0.6	-0.7	0.3	0.4	-0.9	0.9	0.2	0.1	0.0	0.2	0.1	0.4	-0.3	0.3	-0.2	0.9
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	3.2	0.0	0.6	1.1	0.7	-0.5	-1.1	-1.8	-0.2	0.1	-1.3	0.0	-0.0	-0.1	-0.1	-0.2	-0.0	-0.2	-1.0
Age at first live birth	0.3	0.6	3.0	0.2	0.7	-0.7	1.0	-0.8	0.1	-1.7	0.2	-0.7	-0.1	-0.8	-0.7	-0.6	-0.9	-0.4	-0.8	-0.5	-1.0
Angina (self-reported)	0.3	0.3	2.2	-0.6	-0.8	-1.5	-0.2	-0.2	0.0	0.7	0.4	-0.7	-0.3	-0.4	-0.7	-0.3	-0.5	-0.1	-0.4	-0.5	-0.2
Migraine (self-reported)	0.3	0.4	1.9	0.3	0.4	1.3	1.0	0.1	1.4	-0.1	-0.8	0.3	0.1	-0.1	0.7	-0.6	0.5	0.3	0.5	0.5	-0.7
Arm predicted mass (right)	0.3	1.3	4.1	-0.4	-1.0	-0.8	1.0	-0.7	-0.3	-0.6	-0.2	-1.4	-0.5	-1.1	-0.6	-1.7	-1.7	-1.1	-2.0	-0.8	-2.0
Smoking status: Previous	0.3	0.4	3.1	-0.8	0.0	-1.8	-1.2	0.1	0.8	-0.1	-0.1	-0.5	0.4	0.5	-0.4	0.5	-0.6	-0.1	-0.2	-0.2	0.2
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.2	0.2	-0.2	0.2	-0.3	0.2	1.0	-0.3	0.9	0.2	-0.8	0.4	0.7	0.0	0.7	0.8	1.1	0.1	0.3
Diabetes diagnosed by doctor	0.3	0.5	2.1	-0.1	0.3	-0.7	-0.2	-0.6	1.0	-0.4	0.7	-0.8	1.3	-0.0	-1.4	-0.1	-0.6	-0.3	0.4	-1.1	-0.1
Back pain experienced in last month	0.3	0.5	2.7	0.2	-0.3	1.7	0.5	0.4	-1.3	0.6	0.4	0.4	0.6	0.4	0.0	0.6	0.4	0.3	0.9	0.6	0.7
Asthma (self-reported)	0.3	0.5	3.6	-0.1	-1.9	1.3	0.9	0.2	-0.4	1.2	0.1	-0.4	-0.4	0.5	0.8	-0.0	-0.0	0.4	0.5	0.1	0.0
Wears glasses or contact lenses	0.3	0.3	1.9	-0.1	-0.0	0.6	1.4	-0.5	0.3	0.4	-0.3	-0.5	-0.2	-0.9	-0.1	-0.7	-0.1	-0.7	-0.4	-0.2	0.3
Medication: Paracetamol	0.3	0.5	2.1	-0.3	0.4	0.7	-1.3	-0.8	-1.5	-0.9	-0.8	-0.5	-0.0	-0.4	-0.8	-0.6	0.1	-0.8	0.0	-0.2	0.5
Basal metabolic rate	0.3	1.8	4.6	-0.9	-0.7	-0.3	1.0	-1.0	-1.0	-0.8	-0.9	-1.7	-1.3	-1.3	-0.8	-1.8	-2.0	-1.5	-2.1	-1.2	-2.1
Fractured/broken bones in last 5 years	0.3	0.4	3.8	-0.2	-0.7	-1.1	-1.9	0.2	-0.2	0.3	0.3	-0.4	0.0	0.0	0.1	0.5	-0.8	0.4	-0.4	0.4	-0.4
Supplements: Calcium	0.3	0.4	1.8	-0.6	-1.4	-0.8	-0.3	-0.0	-0.1	-0.6	-0.2	-0.4	0.6	0.2	-1.0	0.5	-0.9	0.5	0.2	-0.3	-0.1
Major Depression (MDD)	0.2	0.3	1.9	1.4	-0.4	-0.6	-0.9	0.1	0.3	0.4	-0.1	0.2	-0.1	0.2	0.8	-0.1	0.5	0.0	0.3	0.9	-0.2
Reaction Time	0.2	0.4	2.8	-0.6	1.0	0.9	0.8	-0.5	-1.7	-0.6	-0.1	-0.5	-0.0	0.2	0.0	-0.2	0.2	-0.1	0.6	-0.1	0.0
Blood Eosinophil Count	0.2	1.6	5.1	2.2	1.4	-0.4	-1.6	0.3	2.0	0.5	1.0	0.8	1.8	0.8	-0.1	0.6	1.5	0.3	1.6	1.2	1.8
Smoking Status	0.2	0.4	1.4	0.9	0.2	1.2	-0.7	-0.3	-0.7	0.6	0.5	-0.4	1.0	-0.1	-0.8	0.6	-0.4	-0.9	0.0	0.3	0.8
Number of treatments/medications taken	0.2	0.4	2.5	0.1	-1.6	-0.3	-0.4	-0.2	-0.5	0.8	-0.1	-1.1	0.3	-0.3	-0.6	-0.1	-0.8	-0.6	-0.2	0.0	0.3
Relative age of first facial hair	0.2	0.5	4.6	0.2	0.5	0.4	2.2	0.3	0.6	-0.5	0.4	-0.0	0.0	0.6	0.1	1.2	-0.4	-0.0	0.8	0.2	0.5
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	1.1	-0.6	0.4	0.5	-0.6	-0.5	-0.9	-0.6	-0.0	-0.4	-0.2	-0.1	-0.4	0.1	-0.4	-0.1	-0.0	-1.1	-0.4
Medication: Co-codamol	0.2	0.2	1.0	-0.5	-0.3	1.0	0.9	0.2	-0.5	0.0	0.1	-0.4	0.0	0.2	-0.1	0.2	-0.3	-0.1	0.6	-0.3	0.4
Diabetes (father)	0.2	0.3	1.4	-0.7	-0.5	0.3	1.2	0.0	-0.4	0.9	-0.4	-0.5	-0.8	0.0	-0.1	-0.9	0.3	-0.1	0.2	-0.3	0.2
Diabetes (mother)	0.2	0.3	1.5	0.9	0.1	1.2	0.1	-0.1	0.0	0.9	0.8	0.2	0.4	-0.0	0.0	0.4	0.2	-0.4	0.2	0.6	0.9
Average weekly fortified wine intake	0.2	0.3	1.5	0.7	0.4	1.2	-0.3	-0.4	0.6	-0.3	0.6	0.1	1.1	-0.3	-0.5	-0.1	0.1	-0.2	-0.1	-0.2	0.3
Relative age voice broke	0.2	0.2	1.7	-0.1	0.1	0.2	0.3	0.6	0.2	0.0	0.7	0.2	1.3	0.3	-0.1	0.2	0.4	0.6	0.2	0.7	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.4	-0.2	0.6	0.9	-1.0	-0.8	0.9	-0.1	-1.0	0.4	-0.3	0.2	-1.2	-0.2	0.8	-0.3	-0.0	-0.3	0.8
Hayfever, allergic rhinitis or eczema	0.2	0.3	1.6	0.5	-1.2	0.3	-0.0	-0.5	-1.3	0.7	-0.6	-0.1	-0.4	-0.6	0.1	-0.5	-0.1	-0.7	-0.5	0.3	-0.4
Fluid intelligence score	0.2	0.3	4.9	0.4	-0.2	-2.2	-0.7	0.1	0.2	0.3	0.3	0.0	-0.2	-0.0	0.2	-0.1	-0.0	0.3	-0.1	0.1	-0.4
Father’s age at death	0.2	0.2	1.0	0.7	0.8	0.5	1.0	0.0	-0.0	0.2	0.2	0.5	0.8	0.4	0.4	0.2	0.3	-0.1	-0.5	0.6	-0.1
Asthma	0.2	0.5	3.2	0.1	-1.8	1.2	0.6	0.2	-0.5	1.1	0.2	-0.2	-0.5	0.5	0.9	0.1	0.2	0.3	0.6	0.1	0.2
Arm fat-free mass (right)	0.2	1.2	3.4	-0.5	-0.9	-0.6	1.2	-0.7	-0.3	-0.6	-0.3	-1.4	-0.4	-1.0	-0.6	-1.6	-1.8	-1.1	-1.8	-0.9	-1.8
Shortness of breath walking on level ground	0.2	0.2	1.2	0.6	0.7	-0.1	-1.1	0.3	-0.1	0.2	0.2	0.1	0.3	0.1	1.1	-0.0	0.4	-0.2	0.1	-0.0	0.1
Comparative height size at age 10	0.2	1.3	5.3	-0.8	0.7	0.2	0.2	-0.7	-1.0	-1.0	0.4	-1.3	-1.0	-1.1	-1.1	-0.6	-2.2	-0.8	-1.8	-0.7	-2.3
Age at last live birth	0.2	0.2	1.4	1.2	0.6	-0.7	0.1	-0.2	-0.2	-0.6	0.6	-0.3	-0.7	-0.2	0.2	-0.3	0.3	-0.2	0.2	0.2	0.2
Whole body fat-free mass	0.2	1.1	3.4	-0.5	-0.7	-0.7	1.1	-0.6	-0.6	-0.6	-0.4	-1.2	-1.0	-1.0	-0.4	-1.4	-1.6	-1.0	-1.8	-0.8	-1.8
Whole body water mass	0.2	1.4	4.2	-0.6	-0.8	-0.7	1.1	-0.7	-0.7	-0.8	-0.6	-1.4	-1.1	-1.1	-0.5	-1.6	-1.8	-1.1	-2.0	-0.9	-2.1
Average weekly champagne plus white wine intake	0.2	0.3	1.2	-0.6	-0.9	-0.4	-1.1	0.0	-0.6	0.1	-1.0	0.2	-0.4	-0.0	-0.2	0.1	0.1	0.4	-0.5	0.2	0.1
High cholesterol (Self-reported)	0.2	0.3	3.0	-0.0	-0.2	-1.7	-0.4	0.1	0.6	0.4	0.2	-0.2	0.9	0.1	-0.3	0.3	0.2	-0.4	0.1	-0.1	1.2
Medication: Atorvastatin	0.2	0.3	0.9	0.3	0.9	-0.0	-0.8	-0.4	0.3	-0.3	-0.2	0.2	0.9	-0.1	-0.9	-0.3	0.9	-0.2	0.4	0.0	0.8
Ever smoked	0.2	0.4	1.2	-0.6	0.4	0.2	-1.1	-0.4	-0.9	-0.2	-0.0	-0.9	1.1	-0.4	-0.9	-0.0	-0.8	-1.0	-0.4	-0.4	0.5
Arm fat-free mass (left)	0.2	1.0	3.0	-0.4	-0.5	-0.2	1.1	-0.7	-0.6	-0.6	-0.3	-1.3	-0.6	-1.0	-0.6	-1.4	-1.6	-1.2	-1.7	-0.8	-1.7
Irritability	0.2	0.3	1.6	1.0	-1.3	0.2	-0.9	-0.1	-0.2	0.4	-1.2	0.1	0.1	0.1	0.3	-0.1	-0.1	-0.5	-0.1	0.7	-0.4
Cholesterol lowering medication	0.2	0.3	2.0	0.1	-1.0	-0.5	0.8	0.5	0.5	0.7	0.3	-0.3	1.4	0.2	0.2	0.0	0.1	0.5	0.3	0.4	0.2
Pain experienced in last month	0.2	0.4	4.1	-0.1	-0.9	-0.4	0.2	-0.1	2.0	-0.3	0.0	0.0	-0.5	-0.3	-0.3	-0.3	0.0	0.1	-0.3	-0.7	-0.1
Impedance of whole body	0.2	0.8	4.0	0.6	0.6	0.9	-0.8	0.3	0.7	0.7	1.3	0.3	0.4	1.0	-0.4	2.0	0.1	0.6	1.4	0.6	1.0
Arm predicted mass (left)	0.2	1.2	3.5	-0.5	-0.7	-0.4	1.1	-0.8	-0.6	-0.6	-0.3	-1.4	-0.6	-1.2	-0.7	-1.6	-1.7	-1.3	-1.9	-1.0	-1.7
Alzheimer’s Disease (in father)	0.1	0.1	0.7	0.3	-0.7	0.9	0.2	0.1	-0.4	0.3	-0.5	0.0	-0.2	-0.2	0.3	0.2	-0.2	-0.4	0.0	0.3	0.3
LDL Cholesterol	0.1	0.2	1.2	-0.5	0.7	0.0	1.1	0.6	0.4	0.4	0.5	-0.0	0.2	0.6	0.5	-0.1	0.4	0.4	0.1	-0.2	0.5
Triglycerides	0.1	0.2	0.6	0.2	-0.8	-0.2	-0.5	0.1	0.3	0.4	-0.4	-0.1	-0.7	-0.5	0.8	-0.5	-0.2	0.0	-0.7	0.2	-0.3
Blood Red Count	0.1	0.8	4.0	0.8	2.0	0.3	1.6	0.4	0.1	0.0	1.6	1.2	0.4	0.3	0.4	0.8	1.0	0.8	0.5	0.1	0.6
Blood White Count	0.1	0.8	2.6	-0.3	0.4	-0.0	-1.4	-0.8	-1.2	0.3	-0.9	-0.5	-0.3	-1.4	-1.3	-1.6	-0.1	-0.8	-1.4	-0.7	-0.6
Height	0.1	1.7	6.0	1.9	-1.8	-1.2	0.6	0.5	1.3	0.3	2.5	-0.6	0.5	0.5	0.9	0.6	-1.8	1.1	-0.2	1.3	-2.3
Allergy or Eczema	0.1	0.3	2.0	0.7	-0.6	-0.1	-0.4	0.2	-1.4	0.3	0.0	0.6	0.1	-0.1	0.5	-0.2	0.6	-0.2	0.2	0.7	0.4
Tanning	0.1	1.1	7.3	0.2	2.4	2.7	0.7	0.2	-0.6	-1.5	-0.6	1.3	-0.1	0.1	0.1	0.1	1.0	0.4	0.2	0.4	-0.0
Sitting height	0.1	0.7	2.2	0.3	-1.2	0.4	1.0	-0.2	-1.5	0.7	0.7	-0.9	-1.4	-0.2	-0.7	0.1	-1.4	-0.5	-0.7	0.1	-0.9
Allergy	0.1	0.3	1.7	-0.5	1.1	0.0	0.4	0.3	1.3	-0.6	0.4	0.3	0.7	0.3	-0.5	0.3	0.4	0.7	0.5	-0.1	0.6
Impedance of arm (right)	0.1	0.4	2.3	-0.0	0.9	1.0	-0.7	-0.1	0.1	0.2	0.3	-0.3	-0.8	0.5	-0.5	1.5	-0.4	0.1	0.9	-0.1	0.5
Trunk fat-free mass	0.1	0.7	2.5	0.2	-0.7	-0.7	1.4	-0.2	-0.0	-0.3	0.3	-0.9	-0.4	-0.6	-0.0	-1.0	-1.4	-0.6	-1.5	-0.2	-1.6
Impedance of arm (left)	0.1	0.4	1.4	-0.6	0.3	0.6	-1.2	-0.5	0.2	-0.2	-0.3	-0.7	-1.1	0.1	-1.1	1.0	-0.9	-0.1	0.5	-0.3	0.0
Trunk predicted mass	0.1	0.7	2.4	0.2	-0.6	-0.6	1.5	-0.2	-0.0	-0.3	0.3	-0.8	-0.4	-0.6	-0.1	-0.9	-1.4	-0.6	-1.5	-0.2	-1.5
Standing height	0.1	0.8	3.5	1.0	-1.2	0.1	0.7	0.3	0.3	0.5	1.9	-1.0	-0.6	0.4	-0.0	0.8	-1.8	0.2	-0.3	0.8	-1.3
Guilty feelings	0.1	0.2	0.7	0.4	0.3	0.1	-0.6	-0.2	0.6	-0.2	0.8	-0.1	0.4	-0.0	0.1	0.0	-0.5	0.3	-0.5	-0.3	-0.5
Hair Pigment	0.0	0.5	1.8	-0.9	-0.9	-0.8	-1.3	0.2	-0.4	0.5	-0.6	-0.5	0.4	0.3	0.2	1.3	-1.3	-0.0	0.1	-0.0	0.4

Hub : Genes

AFAP1L1

Models

Trait associations