Hub : Genes

AGBL4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1510	0.0510	0.00035	0.024	0.038	0.055	0.046	0.041	0.00053	1.9e-05	2.7e-07	2.6e-06	7.5e-06
2	METSIM	Adipose	0.0250	0.0116	0.00100	0.023	0.015	0.006	0.015	0.017	0.00016	2.1e-03	4.0e-02	2.3e-03	1.3e-03
3	ROSMAP	Brain Pre-frontal Cortex	0.0732	0.0318	0.00210	0.026	0.017	0.024	0.025	0.034	0.00022	2.2e-03	3.8e-04	3.1e-04	3.0e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	2.2	3.5	8.9	3.0	-0.7	1.1
Bipolar Disorder or Schizophrenia	1.4	3.4	5.0	2.1	-2.2	0.7
Depressed Affect (Nagel 2018)	0.7	1.4	1.8	1.3	-1.2	1.0
Depression (Nagel 2018)	0.4	0.7	1.2	0.8	-1.1	0.5
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.0	-0.3	-1.0	-0.5
Neuroticism (Nagel 2018)	0.5	1.1	1.4	0.8	1.0	1.2
Schizophrenia (2018)	0.9	1.8	5.3	0.1	-2.3	0.0
Schizophrenia vs Biploar Disorder	3.1	4.1	6.3	-2.5	-1.9	-1.6
Worry (Nagel 2018)	2.9	6.0	16.2	-0.1	4.0	1.4
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	0.5	-0.7	0.0
Alzheimer’s Disease (in father)	0.2	0.2	0.3	-0.1	0.5	-0.6
Alzheimer’s Disease (including proxy)	0.6	0.8	1.3	0.1	-1.1	-1.1
Crohns Disease (2017)	0.5	1.1	3.2	-0.2	1.8	0.3
Irritable Bowel Disease (IBD)	1.8	4.2	11.4	0.0	3.4	1.1
Ulcerative Colitis (UC)	2.2	4.2	11.7	-0.2	3.4	0.9
Major Depression (MDD)	0.8	0.9	1.9	-0.9	-1.4	0.3
Reaction Time	8.3	15.9	28.0	1.9	5.3	4.0
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.2	-0.4	0.4	0.1
Breast Cancer	0.4	1.0	1.7	-1.3	-1.1	-0.5
Ovarian Cancer	0.4	0.6	0.9	1.0	-0.7	0.6
Prostate Cancer	0.6	0.8	1.6	-0.7	0.5	-1.3
Age at First Birth	1.1	1.6	3.0	1.7	0.1	1.3
Bipolar Disorder (2011)	0.6	0.5	0.9	0.8	0.1	1.0
Body Mass Index (BMI) (2010)	2.1	2.8	7.8	0.0	-2.8	-0.8
Coronary Artery Disease (CAD)	0.8	1.0	2.3	0.0	-1.5	-0.8
Crohns Disease (2012)	1.3	2.1	3.8	1.3	2.0	0.9
Mean Putamen Volume	0.8	0.9	2.7	-0.0	-1.6	-0.3
Fasting Glucose	0.2	0.3	0.5	0.7	0.1	0.6
HbA1C	0.5	0.5	1.2	0.3	0.5	-1.1
HDL Cholesterol	0.1	0.2	0.6	-0.8	-0.2	-0.2
LDL Cholesterol	1.9	2.9	4.6	1.6	2.1	1.3
Lupus	0.3	0.4	0.9	1.0	0.5	0.2
Neuroticism (2016)	0.4	0.6	1.4	-1.2	0.2	-0.6
Primary Biliary Cirrhosis	0.1	0.2	0.2	0.5	-0.4	-0.4
Rheumatoid Arthritis	1.2	1.6	2.9	1.2	-1.7	-0.7
Schizophrenia (2014)	1.3	2.9	8.5	0.5	-2.9	-0.0
Triglycerides	0.2	0.4	0.6	-0.6	-0.2	-0.8
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.1	0.2	-0.0	0.2
Ulcerative Colitis	0.5	0.8	1.7	-0.7	1.3	0.1
Blood Eosinophil Count	0.2	1.5	3.5	-1.9	-0.8	0.5
Blood Platelet Count	0.1	0.9	1.8	-1.4	-0.8	0.2
Blood Red Count	0.0	0.4	1.2	0.2	-1.1	0.0
Blood White Count	0.7	5.1	14.9	-0.1	-3.9	-0.5
Heel T-Score	0.0	0.0	0.1	-0.0	0.3	0.1
BMI	3.7	21.5	58.4	-1.1	-7.6	-2.2
Height	0.0	0.5	1.2	-0.1	-1.1	-0.5
Waist Hip Ratio (WHR)	1.3	6.0	12.3	1.6	-3.5	-1.8
Systolic Blood Pressure	0.1	0.3	0.9	0.1	-1.0	-0.1
Smoking Status	5.1	12.3	31.0	1.7	-5.6	-1.7
Allergy or Eczema	0.5	1.2	3.5	1.9	0.2	0.5
Cardiovascular Disease	0.5	1.5	4.4	-0.4	-2.1	-0.3
Hypothyroidism (self reported)	0.2	0.6	1.0	0.4	-1.0	-0.7
Respiratory disease	1.0	2.3	2.8	-1.7	-1.1	-1.6
Type 2 Diabetes (T2D) (2018)	0.6	1.2	1.8	1.3	-0.2	1.4
Lung FEV1/FVC ratio	0.4	2.0	5.9	-0.3	-2.4	-0.3
Lung FVC	0.5	2.8	4.6	-0.1	2.1	2.0
Neuroticism	0.3	0.8	1.6	-0.0	1.3	0.9
Chronotype (morning person)	2.7	6.2	13.9	-1.3	-3.7	-1.7
Hair Pigment	0.0	0.6	0.8	0.5	-0.9	0.8
Tanning	0.1	1.1	2.7	0.5	-1.6	-0.5
Hand grip strength (left)	0.6	1.7	5.1	0.2	-2.2	0.1
Number of treatments/medications taken	0.4	0.8	1.1	1.0	-1.1	0.5
Average weekly spirits intake	0.8	1.0	1.4	0.9	-0.8	1.2
Sensitivity / hurt feelings	0.8	1.3	2.3	0.6	1.1	1.5
Frequency of depressed mood in last 2 weeks	0.6	0.9	2.4	-0.3	-1.6	-0.3
Hearing difficulty/problems: Yes	0.4	0.6	1.8	-0.1	-1.3	0.2
Relative age of first facial hair	0.3	0.7	1.0	-1.0	-1.0	-0.1
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.1	-0.2	-1.1	-0.9
Ever used hormone-replacement therapy (HRT)	1.3	1.6	4.8	0.1	2.2	-0.0
Ever had hysterectomy (womb removed)	1.2	1.4	2.8	1.7	0.3	1.1
Systolic blood pressure, automated reading	0.4	1.1	2.1	-0.7	-1.5	0.7
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.7	0.4	-0.9	0.6
Angina	0.6	0.7	1.4	1.2	-0.8	0.4
Medication for hormone replacement therapy	0.2	0.3	0.7	-0.0	0.8	0.2
Vitamin and mineral supplements	1.1	1.6	3.3	-0.7	-0.9	-1.8
Supplements: Zinc	1.1	1.2	2.3	1.5	-0.9	0.6
Medication: Co-codamol	0.5	0.5	1.3	-0.5	-0.2	-1.1
Medication: Metformin	0.9	1.2	3.4	0.5	-1.8	0.3
Diabetes (father)	0.1	0.1	0.1	-0.3	0.3	0.1
Diabetes (mother)	2.2	2.8	5.5	2.3	1.5	0.9
Severe depression (siblings)	3.9	4.4	7.3	2.7	0.2	2.4
Pack years adult smoking proportion	3.8	5.8	16.9	0.8	-4.1	-0.0
Impedance of leg (right)	0.6	2.8	4.2	1.6	2.0	-1.4
Leg fat-free mass (left)	2.3	11.9	33.3	-1.1	-5.8	-1.2
Trunk fat percentage	4.3	17.2	42.9	-0.3	-6.5	-2.9
Hand grip strength (right)	0.9	2.6	6.7	1.0	-2.6	0.3
Townsend deprivation index at recruitment	4.3	6.0	15.4	1.4	-3.9	-0.6
Current tobacco smoking	3.3	5.5	15.4	0.8	-3.9	-0.6
Average weekly fortified wine intake	0.4	0.5	1.4	-0.4	1.2	0.0
Maternal smoking around birth	1.2	1.8	5.2	-0.2	-2.3	-0.3
Fed-up feelings	0.4	0.8	2.2	0.3	-1.5	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	3.1	1.2	-1.8	0.5
Relative age voice broke	0.7	1.1	1.6	-1.1	0.7	-1.3
Taking other prescription medications	0.0	0.1	0.2	0.4	0.1	-0.1
Age when periods started (menarche)	0.5	1.2	3.0	0.7	-1.7	0.1
Bilateral oophorectomy (both ovaries removed)	1.6	1.9	3.6	1.9	-0.1	1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	4.6	0.6	-2.1	0.9
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.8	0.9	0.1	-0.2
Qualifications: CSEs or equivalent	0.4	0.6	1.6	1.3	0.4	0.2
Serious illness, injury or assault to yourself	0.7	0.9	1.3	1.0	-1.1	-0.5
High blood pressure	0.6	1.6	3.9	-0.9	-2.0	-0.5
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.0	1.4	0.4	-0.1
Multivitamins +/- minerals	0.8	1.0	2.0	0.8	-0.6	1.4
Stomach or abdominal pain in last month	0.4	0.5	1.0	1.0	-0.2	-0.6
Supplements: Glucosamine	0.2	0.3	0.7	-0.3	-0.3	0.8
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.7	-0.5	0.8	-0.1
Medication: Atenolol	0.4	0.4	1.2	-1.1	0.2	-0.3
Medication: Levothyroxine sodium	0.3	0.5	1.0	1.0	0.1	0.7
Sitting height	0.3	1.8	3.7	-0.1	-1.9	-1.3
Chronic bronchitis/emphysema (father)	0.3	0.4	1.0	-0.4	-1.0	-0.2
High blood pressure (mother)	0.6	0.8	2.4	-0.0	-0.4	-1.6
Body mass index (BMI)	4.2	17.8	50.6	-0.8	-7.1	-1.6
Impedance of leg (left)	0.5	2.5	4.6	1.0	2.1	-1.4
Leg predicted mass (left)	2.2	11.8	32.9	-1.1	-5.7	-1.1
Trunk fat mass	4.9	20.9	54.4	-0.5	-7.4	-2.8
Waist circumference	4.9	18.0	49.4	0.1	-7.0	-2.1
Number of incorrect matches in round	1.7	2.9	8.1	-2.8	-0.3	-0.7
Past tobacco smoking	2.3	4.2	8.3	-1.5	2.9	1.4
Alcohol usually taken with meals	2.2	3.5	8.7	-1.3	3.0	0.4
Nervous feelings	4.9	9.1	19.9	0.5	4.5	2.7
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.8	1.4	-0.6	0.7
Hearing difficulty/problems with background noise	0.1	0.1	0.3	0.1	-0.5	0.3
Hair/balding pattern: Pattern 2	1.0	1.3	3.8	-0.4	-0.1	-1.9
Had menopause	1.1	1.4	3.2	-0.6	1.8	0.7
Had other major operations	1.1	1.3	3.3	-0.8	-0.0	-1.8
Forced vital capacity (FVC)	0.1	0.2	0.6	-0.2	0.7	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.6	0.3	-1.6	-0.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.8	0.0	-0.4	-0.9
Qualifications: None of the above	0.6	1.3	3.5	-0.5	0.5	1.9
Financial difficulties in last 2 years	2.2	3.0	7.5	0.7	-2.7	-1.0
Mouth/teeth dental problems	1.4	2.2	6.3	0.3	2.5	0.3
Heart attack	0.4	0.5	0.9	0.4	-0.9	-0.6
Allergy	0.3	0.7	1.0	-1.0	0.7	0.7
Pain all over the body in last month	3.3	3.5	6.9	0.6	2.6	1.8
Diabetes (self-reported)	1.4	2.2	3.5	1.9	-0.9	1.5
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.0	1.0	0.7	1.0
Medication: Ramipril	0.6	0.8	2.3	0.2	-1.5	-0.1
Medication: Simvastatin	0.6	0.8	2.3	-1.5	-0.4	-0.1
Fluid intelligence score	0.2	0.5	0.8	-0.9	-0.3	-0.7
Illnesses of siblings	1.1	1.5	3.8	-0.8	1.9	0.3
Neuroticism score	0.2	0.4	0.6	0.3	0.7	0.8
Weight	4.0	19.8	54.3	-0.9	-7.4	-2.0
Impedance of arm (right)	1.0	4.5	10.6	0.2	3.2	-1.7
Arm fat percentage (right)	4.1	16.2	41.1	-0.7	-6.4	-2.6
Trunk fat-free mass	1.5	8.8	24.9	-1.2	-5.0	-0.4
Hip circumference	2.3	9.8	26.4	-0.7	-5.1	-1.6
Time employed in main current job	0.3	0.3	0.9	0.2	0.9	0.1
Alcohol intake versus 10 years previously	2.6	4.0	8.0	-0.0	-2.8	-2.0
Father’s age at death	1.4	1.9	4.7	0.2	2.2	1.0
Worrier / anxious feelings	1.4	2.6	5.6	0.9	2.4	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.4	-0.0	-1.2	-1.0
Falls in the last year	1.6	2.2	2.9	-1.7	-1.1	-1.6
Hair/balding pattern: Pattern 3	0.6	0.9	1.5	1.2	-1.1	0.3
Number of live births	1.5	2.1	3.1	0.8	1.8	1.6
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.2	-0.0	0.5	0.4
Pulse rate	0.6	1.1	1.6	-1.2	-1.3	-0.2
Happiness	0.1	0.1	0.2	0.4	-0.3	-0.2
Noisy workplace	0.1	0.1	0.3	0.1	-0.6	-0.3
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.2	-0.8	-0.8	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.7	0.3	-1.6	-0.0
Mouth/teeth dental problems: Dentures	1.1	1.9	5.0	-0.7	-2.2	-0.5
Asthma	0.4	0.9	1.7	-0.5	-0.8	-1.3
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.2	-1.1	-0.8	-0.5
Medication: Cholesterol lowering	0.1	0.1	0.3	-0.6	0.1	0.0
Depression (self-reported)	1.5	1.8	2.6	1.6	-0.6	1.6
Medication: Lansoprazole	2.9	3.3	7.4	-1.5	0.5	-2.7
Prospective memory result	0.9	1.1	2.5	0.0	-1.0	-1.6
Lung cancer (father)	0.1	0.1	0.2	0.3	0.1	-0.4
Illnesses of mother	0.9	1.1	2.6	-0.3	-1.6	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	0.9	0.5	0.8	0.9
Pulse wave Arterial Stiffness index	2.3	2.7	4.5	2.1	-0.3	1.9
Impedance of arm (left)	1.3	6.2	17.1	0.5	4.1	-1.2
Arm fat mass (right)	4.5	18.7	50.4	-0.7	-7.1	-2.3
Trunk predicted mass	1.6	8.9	25.0	-1.2	-5.0	-0.5
Standing height	0.2	1.5	3.0	-0.5	-1.7	-1.1
Length of working week for main job	1.3	1.5	3.4	0.9	-1.9	0.3
Exposure to tobacco smoke at home	1.9	2.1	5.3	2.3	0.4	0.9
Breastfed as a baby	1.6	2.0	5.9	-2.4	-0.3	-0.1
Tense / ‘highly strung’	0.6	1.0	3.1	0.0	1.8	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	2.7	1.6	0.3	1.3
Hair/balding pattern: Pattern 4	0.4	1.0	1.5	0.3	-1.2	1.2
Birth weight of first child	1.5	2.6	7.4	0.5	-2.7	-0.6
Peak expiratory flow (PEF)	0.0	0.1	0.2	0.3	-0.5	-0.1
Pulse wave reflection index	2.0	2.5	4.0	2.0	1.0	1.6
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.9	1.0	-0.4	0.4
Loud music exposure frequency	0.9	1.0	2.6	1.6	-0.2	0.6
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	0.9	-0.1	-0.6	-0.9
Mouth/teeth dental problems: Bleeding gums	4.4	5.7	13.1	1.7	-3.6	-1.1
Blood clot in the leg (DVT)	0.4	0.5	1.0	0.5	-0.6	-1.0
Medication: Paracetamol	0.3	0.5	1.2	0.6	-1.1	0.1
Headache pain in last month	0.4	0.8	1.9	-0.4	1.4	0.4
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.2	0.8	0.3	1.1
Glaucoma (self-reported)	1.9	2.2	4.8	-1.2	-2.2	-0.7
Gout (self-reported)	0.3	0.4	0.6	-0.3	-0.6	0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.6	0.8	-0.6	-0.4
Medication: Amlodipine	1.1	1.5	2.3	-1.2	-0.9	-1.5
Medication: Ventolin 100micrograms inhaler	3.4	4.4	9.9	-1.2	-1.3	-3.2
Birth weight	0.7	1.6	2.6	-1.6	-1.1	-1.0
Chronic bronchitis/emphysema (mother)	1.3	1.5	2.8	-1.2	-1.7	-0.3
High blood pressure (siblings)	1.0	1.4	4.2	0.0	-2.0	-0.4
Forced vital capacity (FVC), Best measure	0.1	0.4	0.8	0.4	0.9	0.3
Body fat percentage	4.6	18.3	47.1	-0.3	-6.9	-2.8
Leg fat percentage (right)	4.8	17.4	47.7	0.2	-6.9	-2.1
Arm fat-free mass (right)	2.2	11.5	33.5	-0.8	-5.8	-0.4
Exposure to tobacco smoke outside home	1.5	2.0	2.7	1.6	-1.5	0.9
Comparative body size at age 10	0.6	1.6	4.0	0.2	-2.0	0.8
Number of full brothers	0.5	0.6	1.4	1.2	-0.4	0.3
Worry too long after embarrassment	0.9	1.5	3.8	-0.8	2.0	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.7	-0.4	0.1	-0.8
Wheeze or whistling in the chest in last year	2.1	3.7	8.4	0.3	-2.9	-1.6
Number of children fathered	1.4	1.6	2.4	-0.3	1.5	1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.8	-0.2	1.7	0.0
Age at first live birth	0.2	0.3	0.4	-0.6	0.6	-0.3
Pulse wave peak to peak time	2.2	2.6	4.5	-2.1	0.2	-1.8
Health satisfaction	1.9	2.5	3.5	0.7	-1.9	-1.8
Shortness of breath walking on level ground	1.4	1.7	4.3	0.4	-2.1	-0.7
Qualifications: College or University degree	0.1	0.3	0.7	0.1	0.3	-0.9
Eye problems/disorders: None of the above	0.3	0.4	1.1	0.3	1.1	0.0
Mouth/teeth dental problems: Loose teeth	1.6	1.9	3.9	-1.0	-2.0	-0.8
Emphysema/chronic bronchitis	0.8	0.9	2.1	0.6	-1.5	-0.3
Medication for pain relief, constipation, heartburn	0.8	1.3	2.0	-1.4	1.4	-0.3
Neck or shoulder pain in last month	1.0	1.4	3.1	-0.2	-1.8	-1.1
Medication: Blood pressure	1.3	2.3	3.2	-1.2	-1.5	-1.8
Angina (self-reported)	0.8	1.0	2.3	1.5	-0.4	0.8
Migraine (self-reported)	1.0	1.3	2.1	0.7	1.5	1.1
Medication: Ibuprofen	0.0	0.0	0.0	-0.1	0.0	-0.2
Medication: Allopurinol	0.3	0.4	0.6	0.3	-0.7	0.8
Medication: Omeprazole	0.5	0.6	1.2	0.3	-0.6	-1.1
Medication: Seretide 50 evohaler	0.5	0.5	1.1	-1.1	0.3	-0.6
Mean time to correctly identify matches	8.3	15.8	26.1	1.5	5.1	4.4
Heart disease (mother)	0.2	0.2	0.4	0.7	0.4	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.6	-1.1	1.3	-0.3
Whole body fat mass	5.1	21.4	57.2	-0.5	-7.6	-2.6
Leg fat mass (right)	5.9	23.0	63.2	-0.1	-8.0	-2.4
Arm predicted mass (right)	2.2	11.5	33.9	-0.6	-5.8	-0.4
Pulse rate, automated reading	0.7	2.2	6.0	-0.3	-2.5	-0.8
Alcohol intake frequency.	0.4	0.9	1.6	-1.3	-0.7	-0.7
Comparative height size at age 10	0.5	2.9	5.4	-0.6	-2.3	-1.7
Number of full sisters	0.9	1.1	2.2	-0.7	-0.8	-1.5
Suffer from ‘nerves’	2.0	3.1	6.1	0.8	2.5	1.6
Overall health rating	0.2	0.5	1.0	1.0	-0.4	-0.6
Chest pain or discomfort	0.2	0.2	0.5	0.2	0.4	-0.7
Had major operations	2.7	3.1	6.8	0.1	-2.6	-1.6
Age at last live birth	0.0	0.0	0.0	0.1	0.1	-0.2
Family relationship satisfaction	1.5	1.8	4.5	0.3	-2.1	-0.9
Leg pain on walking	2.0	2.5	3.1	-1.6	-1.8	-1.4
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.8	0.9	-0.5	0.3
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.8	-1.3	-0.1	-0.2
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	3.7	0.1	1.9	0.0
Medication: Aspirin	0.3	0.4	0.6	0.8	-0.6	0.6
Supplements: Vitamin C	0.8	0.9	2.2	-0.8	1.5	-0.1
Knee pain experienced in last month	0.2	0.3	0.6	0.3	-0.3	-0.8
Hypertension (Self-reported)	0.6	1.7	4.1	-0.7	-2.0	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	1.7	-1.3	0.1	-1.1
Illnesses of father: Heart disease	0.3	0.4	0.7	-0.8	0.5	-0.4
Illnesses of siblings: Diabetes	1.3	1.5	2.1	1.4	-1.5	-0.6
Smoking status: Previous	1.2	1.8	2.9	1.7	-1.3	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	4.8	0.1	-0.4	-2.2
Whole body fat-free mass	2.0	11.6	32.5	-1.3	-5.7	-0.8
Leg fat-free mass (right)	2.0	10.6	28.4	-1.4	-5.3	-1.1
Arm fat percentage (left)	3.6	14.2	37.2	-0.5	-6.1	-2.3
Average weekly red wine intake	1.4	2.1	4.4	-0.1	2.1	1.4
Handedness (chirality/laterality): Left-handed	0.5	0.6	0.8	0.9	-0.7	-0.7
Mood swings	0.8	1.5	2.3	1.5	-0.7	1.4
Loneliness, isolation	0.2	0.3	0.8	0.4	0.9	0.3
Long-standing illness, disability or infirmity	0.8	1.2	2.7	0.3	-1.6	-0.8
Ever had bowel cancer screening	0.1	0.1	0.2	-0.5	0.4	0.2
Diabetes diagnosed by doctor	0.8	1.3	2.0	1.4	-1.0	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.3	0.5	-1.5	-0.6
Friendships satisfaction	0.2	0.2	0.3	0.6	-0.2	-0.5
Qualifications: nursing, teaching	0.2	0.4	0.5	0.7	-0.4	-0.7
Commuting to job workplace: Walk	1.2	1.3	3.2	0.8	-1.8	0.2
Eye problems/disorders: Cataract	0.3	0.4	1.1	-0.1	-1.1	-0.2
Mouth/teeth dental problems: Mouth ulcers	1.4	2.3	3.4	-1.0	1.5	1.8
Medication for cholesterol	0.4	0.7	1.8	0.4	-0.1	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	0.8	0.9	-0.7	-0.7
Back pain experienced in last month	1.4	2.0	3.4	-1.1	-1.1	-1.8
Mineral and other dietary supplements	3.0	4.0	8.2	-1.8	-0.8	-2.9
Breast cancer (self-reported)	1.3	1.6	2.5	-0.2	1.6	-1.5
Asthma (self-reported)	0.4	0.9	1.8	-0.6	-0.7	-1.4
Osteoporosis (self-reported)	0.4	0.5	1.5	-0.1	1.2	0.3
Osteoarthritis (self-reported)	0.2	0.3	0.5	0.7	-0.6	0.2
Medication: Aspirin	0.8	1.1	1.8	1.4	-0.5	1.1
Medication: Gliclazide	0.5	0.6	1.3	0.4	-1.1	-0.5
Illnesses of father: None of the above (group 1)	0.9	1.2	2.6	1.6	0.7	0.6
Smoking status: Current	3.7	5.9	17.1	0.5	-4.1	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.2	-0.6	1.1	1.0
Whole body water mass	1.9	10.6	29.9	-1.2	-5.5	-0.6
Leg predicted mass (right)	1.9	10.2	27.6	-1.5	-5.2	-1.0
Arm fat mass (left)	4.5	18.5	50.4	-0.6	-7.1	-2.2
Number of self-reported non-cancer illnesses	0.5	0.8	2.0	-0.0	-1.4	-0.7
Average weekly champagne plus white wine intake	0.9	1.3	2.4	-0.6	1.5	1.0
Miserableness	2.4	4.2	7.1	2.3	-2.7	0.3
Guilty feelings	1.0	1.4	2.6	-1.1	-1.6	-0.8
Wears glasses or contact lenses	0.3	0.3	0.8	-0.1	0.3	0.9
Ever taken oral contraceptive pill	1.1	1.2	1.8	0.0	-1.4	-1.3
Hearing aid user	0.8	0.9	2.0	-0.6	-1.4	-0.6
Mother’s age at death	0.1	0.1	0.3	-0.5	0.3	-0.0
Financial situation satisfaction	2.9	3.6	7.1	1.9	-2.7	-0.5
Tinnitus: Yes, now most or all of the time	0.8	1.0	2.5	1.6	-0.2	0.7
Commuting to job workplace: Public transport	1.7	2.1	2.6	1.4	-1.3	-1.6
Eye problems/disorders: Glaucoma	2.9	3.5	9.4	-0.8	-3.1	-0.7
Medication: Blood pressure	0.7	1.3	2.9	-1.1	-1.7	-0.0
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.6	0.7	-0.8	0.2
Supplements: Fish oil (including cod liver oil)	2.9	3.8	6.8	1.6	1.4	2.6
High cholesterol (Self-reported)	0.3	0.5	1.0	-0.5	0.4	1.0
Medication: Bendroflumethiazide	0.6	0.9	2.3	-0.5	-1.5	-0.3
Medication: Paracetamol	0.9	1.4	2.8	1.7	-0.5	1.1
Medication: Lisinopril	0.9	1.2	1.8	-0.8	-1.3	-1.0
Medication: Atorvastatin	0.9	1.1	1.8	0.4	1.4	1.1
Illnesses of father: High blood pressure	0.6	0.8	1.7	-0.6	-1.3	0.5
Alcohol drinker status: Never	3.4	4.0	7.3	-2.7	1.2	-1.8
Ever smoked	2.3	4.1	7.9	1.6	-2.8	-1.4
Basal metabolic rate	2.6	14.4	40.1	-1.3	-6.3	-1.3
Leg fat percentage (left)	4.5	16.1	44.4	-0.2	-6.7	-2.0
Arm fat-free mass (left)	2.6	13.0	37.2	-1.1	-6.1	-0.8
Number of operations (self-reported)	0.9	1.3	2.9	0.2	-1.0	-1.7
Average weekly beer plus cider intake	2.4	3.4	8.6	0.6	-2.9	-1.1
Irritability	2.3	4.0	8.1	2.0	-2.8	0.1
Risk taking	0.5	0.7	1.0	1.0	-0.8	0.7
Ever had prostate specific antigen (PSA) test	2.3	2.6	4.3	0.1	2.1	1.9
Fractured/broken bones in last 5 years	0.2	0.3	0.6	-0.2	0.8	-0.4
Age started oral contraceptive pill	0.3	0.3	0.7	-0.9	-0.4	-0.3
Diastolic blood pressure, automated reading	1.7	5.4	13.4	-1.5	-3.7	-0.7
Ever depressed for a whole week	0.2	0.2	0.4	-0.2	-0.4	-0.7
Unable to work because of sickness or disability	0.7	0.9	1.2	1.1	0.6	1.1
Commuting to job workplace: Cycle	0.6	0.7	0.8	0.9	-0.8	0.8
Myopia	2.4	3.5	9.5	-0.1	-3.1	-1.0
Vascular/heart problems diagnosed by doctor	0.4	1.1	3.0	0.4	1.7	0.3
Cholesterol lowering medication	0.2	0.2	0.5	-0.4	-0.3	0.7
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.7	0.5	-0.5	-1.3
Pain experienced in last month	0.2	0.3	0.9	-0.2	-0.2	-0.9
Supplements: Calcium	3.0	3.3	5.7	1.3	1.6	2.4
Basal cell carcinoma (self-reported)	0.5	0.5	1.4	0.2	-1.2	0.4
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.8	0.3	-0.9	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.5	0.6	-0.4	-1.2
Heart disease (siblings)	0.1	0.1	0.2	0.4	0.5	0.2
Alcohol drinker status: Previous	1.1	1.3	2.2	-1.2	-1.5	0.4
Pack years of smoking	3.6	5.3	16.0	0.2	-4.0	0.0
Impedance of whole body	0.9	4.8	11.4	0.9	3.4	-1.5
Leg fat mass (left)	5.6	21.7	59.8	-0.2	-7.7	-2.3
Arm predicted mass (left)	2.4	12.4	35.2	-1.1	-5.9	-0.9