Hub : Genes

AGBL4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1510 0.0510 0.00035 0.024 0.038 0.055 0.046 0.041 0.00053 1.9e-05 2.7e-07 2.6e-06 7.5e-06
2 METSIM Adipose 0.0250 0.0116 0.00100 0.023 0.015 0.006 0.015 0.017 0.00016 2.1e-03 4.0e-02 2.3e-03 1.3e-03
3 ROSMAP Brain Pre-frontal Cortex 0.0732 0.0318 0.00210 0.026 0.017 0.024 0.025 0.034 0.00022 2.2e-03 3.8e-04 3.1e-04 3.0e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 2.2 3.5 8.9 3.0 -0.7 1.1
Bipolar Disorder or Schizophrenia 1.4 3.4 5.0 2.1 -2.2 0.7
Depressed Affect (Nagel 2018) 0.7 1.4 1.8 1.3 -1.2 1.0
Depression (Nagel 2018) 0.4 0.7 1.2 0.8 -1.1 0.5
Intelligence (Savage-Jansen 2018) 0.1 0.4 1.0 -0.3 -1.0 -0.5
Neuroticism (Nagel 2018) 0.5 1.1 1.4 0.8 1.0 1.2
Schizophrenia (2018) 0.9 1.8 5.3 0.1 -2.3 0.0
Schizophrenia vs Biploar Disorder 3.1 4.1 6.3 -2.5 -1.9 -1.6
Worry (Nagel 2018) 2.9 6.0 16.2 -0.1 4.0 1.4
Alzheimer’s Disease (in mother) 0.2 0.2 0.5 0.5 -0.7 0.0
Alzheimer’s Disease (in father) 0.2 0.2 0.3 -0.1 0.5 -0.6
Alzheimer’s Disease (including proxy) 0.6 0.8 1.3 0.1 -1.1 -1.1
Crohns Disease (2017) 0.5 1.1 3.2 -0.2 1.8 0.3
Irritable Bowel Disease (IBD) 1.8 4.2 11.4 0.0 3.4 1.1
Ulcerative Colitis (UC) 2.2 4.2 11.7 -0.2 3.4 0.9
Major Depression (MDD) 0.8 0.9 1.9 -0.9 -1.4 0.3
Reaction Time 8.3 15.9 28.0 1.9 5.3 4.0
Verbal and Numeric Reasoning (VNR) 0.1 0.1 0.2 -0.4 0.4 0.1
Breast Cancer 0.4 1.0 1.7 -1.3 -1.1 -0.5
Ovarian Cancer 0.4 0.6 0.9 1.0 -0.7 0.6
Prostate Cancer 0.6 0.8 1.6 -0.7 0.5 -1.3
Age at First Birth 1.1 1.6 3.0 1.7 0.1 1.3
Bipolar Disorder (2011) 0.6 0.5 0.9 0.8 0.1 1.0
Body Mass Index (BMI) (2010) 2.1 2.8 7.8 0.0 -2.8 -0.8
Coronary Artery Disease (CAD) 0.8 1.0 2.3 0.0 -1.5 -0.8
Crohns Disease (2012) 1.3 2.1 3.8 1.3 2.0 0.9
Mean Putamen Volume 0.8 0.9 2.7 -0.0 -1.6 -0.3
Fasting Glucose 0.2 0.3 0.5 0.7 0.1 0.6
HbA1C 0.5 0.5 1.2 0.3 0.5 -1.1
HDL Cholesterol 0.1 0.2 0.6 -0.8 -0.2 -0.2
LDL Cholesterol 1.9 2.9 4.6 1.6 2.1 1.3
Lupus 0.3 0.4 0.9 1.0 0.5 0.2
Neuroticism (2016) 0.4 0.6 1.4 -1.2 0.2 -0.6
Primary Biliary Cirrhosis 0.1 0.2 0.2 0.5 -0.4 -0.4
Rheumatoid Arthritis 1.2 1.6 2.9 1.2 -1.7 -0.7
Schizophrenia (2014) 1.3 2.9 8.5 0.5 -2.9 -0.0
Triglycerides 0.2 0.4 0.6 -0.6 -0.2 -0.8
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.1 0.2 -0.0 0.2
Ulcerative Colitis 0.5 0.8 1.7 -0.7 1.3 0.1
Blood Eosinophil Count 0.2 1.5 3.5 -1.9 -0.8 0.5
Blood Platelet Count 0.1 0.9 1.8 -1.4 -0.8 0.2
Blood Red Count 0.0 0.4 1.2 0.2 -1.1 0.0
Blood White Count 0.7 5.1 14.9 -0.1 -3.9 -0.5
Heel T-Score 0.0 0.0 0.1 -0.0 0.3 0.1
BMI 3.7 21.5 58.4 -1.1 -7.6 -2.2
Height 0.0 0.5 1.2 -0.1 -1.1 -0.5
Waist Hip Ratio (WHR) 1.3 6.0 12.3 1.6 -3.5 -1.8
Systolic Blood Pressure 0.1 0.3 0.9 0.1 -1.0 -0.1
Smoking Status 5.1 12.3 31.0 1.7 -5.6 -1.7
Allergy or Eczema 0.5 1.2 3.5 1.9 0.2 0.5
Cardiovascular Disease 0.5 1.5 4.4 -0.4 -2.1 -0.3
Hypothyroidism (self reported) 0.2 0.6 1.0 0.4 -1.0 -0.7
Respiratory disease 1.0 2.3 2.8 -1.7 -1.1 -1.6
Type 2 Diabetes (T2D) (2018) 0.6 1.2 1.8 1.3 -0.2 1.4
Lung FEV1/FVC ratio 0.4 2.0 5.9 -0.3 -2.4 -0.3
Lung FVC 0.5 2.8 4.6 -0.1 2.1 2.0
Neuroticism 0.3 0.8 1.6 -0.0 1.3 0.9
Chronotype (morning person) 2.7 6.2 13.9 -1.3 -3.7 -1.7
Hair Pigment 0.0 0.6 0.8 0.5 -0.9 0.8
Tanning 0.1 1.1 2.7 0.5 -1.6 -0.5
Hand grip strength (left) 0.6 1.7 5.1 0.2 -2.2 0.1
Number of treatments/medications taken 0.4 0.8 1.1 1.0 -1.1 0.5
Average weekly spirits intake 0.8 1.0 1.4 0.9 -0.8 1.2
Sensitivity / hurt feelings 0.8 1.3 2.3 0.6 1.1 1.5
Frequency of depressed mood in last 2 weeks 0.6 0.9 2.4 -0.3 -1.6 -0.3
Hearing difficulty/problems: Yes 0.4 0.6 1.8 -0.1 -1.3 0.2
Relative age of first facial hair 0.3 0.7 1.0 -1.0 -1.0 -0.1
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 1.1 -0.2 -1.1 -0.9
Ever used hormone-replacement therapy (HRT) 1.3 1.6 4.8 0.1 2.2 -0.0
Ever had hysterectomy (womb removed) 1.2 1.4 2.8 1.7 0.3 1.1
Systolic blood pressure, automated reading 0.4 1.1 2.1 -0.7 -1.5 0.7
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 0.7 0.4 -0.9 0.6
Angina 0.6 0.7 1.4 1.2 -0.8 0.4
Medication for hormone replacement therapy 0.2 0.3 0.7 -0.0 0.8 0.2
Vitamin and mineral supplements 1.1 1.6 3.3 -0.7 -0.9 -1.8
Supplements: Zinc 1.1 1.2 2.3 1.5 -0.9 0.6
Medication: Co-codamol 0.5 0.5 1.3 -0.5 -0.2 -1.1
Medication: Metformin 0.9 1.2 3.4 0.5 -1.8 0.3
Diabetes (father) 0.1 0.1 0.1 -0.3 0.3 0.1
Diabetes (mother) 2.2 2.8 5.5 2.3 1.5 0.9
Severe depression (siblings) 3.9 4.4 7.3 2.7 0.2 2.4
Pack years adult smoking proportion 3.8 5.8 16.9 0.8 -4.1 -0.0
Impedance of leg (right) 0.6 2.8 4.2 1.6 2.0 -1.4
Leg fat-free mass (left) 2.3 11.9 33.3 -1.1 -5.8 -1.2
Trunk fat percentage 4.3 17.2 42.9 -0.3 -6.5 -2.9
Hand grip strength (right) 0.9 2.6 6.7 1.0 -2.6 0.3
Townsend deprivation index at recruitment 4.3 6.0 15.4 1.4 -3.9 -0.6
Current tobacco smoking 3.3 5.5 15.4 0.8 -3.9 -0.6
Average weekly fortified wine intake 0.4 0.5 1.4 -0.4 1.2 0.0
Maternal smoking around birth 1.2 1.8 5.2 -0.2 -2.3 -0.3
Fed-up feelings 0.4 0.8 2.2 0.3 -1.5 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.6 3.1 1.2 -1.8 0.5
Relative age voice broke 0.7 1.1 1.6 -1.1 0.7 -1.3
Taking other prescription medications 0.0 0.1 0.2 0.4 0.1 -0.1
Age when periods started (menarche) 0.5 1.2 3.0 0.7 -1.7 0.1
Bilateral oophorectomy (both ovaries removed) 1.6 1.9 3.6 1.9 -0.1 1.4
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.9 4.6 0.6 -2.1 0.9
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.8 0.9 0.1 -0.2
Qualifications: CSEs or equivalent 0.4 0.6 1.6 1.3 0.4 0.2
Serious illness, injury or assault to yourself 0.7 0.9 1.3 1.0 -1.1 -0.5
High blood pressure 0.6 1.6 3.9 -0.9 -2.0 -0.5
Hayfever, allergic rhinitis or eczema 0.3 0.7 2.0 1.4 0.4 -0.1
Multivitamins +/- minerals 0.8 1.0 2.0 0.8 -0.6 1.4
Stomach or abdominal pain in last month 0.4 0.5 1.0 1.0 -0.2 -0.6
Supplements: Glucosamine 0.2 0.3 0.7 -0.3 -0.3 0.8
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 0.7 -0.5 0.8 -0.1
Medication: Atenolol 0.4 0.4 1.2 -1.1 0.2 -0.3
Medication: Levothyroxine sodium 0.3 0.5 1.0 1.0 0.1 0.7
Sitting height 0.3 1.8 3.7 -0.1 -1.9 -1.3
Chronic bronchitis/emphysema (father) 0.3 0.4 1.0 -0.4 -1.0 -0.2
High blood pressure (mother) 0.6 0.8 2.4 -0.0 -0.4 -1.6
Body mass index (BMI) 4.2 17.8 50.6 -0.8 -7.1 -1.6
Impedance of leg (left) 0.5 2.5 4.6 1.0 2.1 -1.4
Leg predicted mass (left) 2.2 11.8 32.9 -1.1 -5.7 -1.1
Trunk fat mass 4.9 20.9 54.4 -0.5 -7.4 -2.8
Waist circumference 4.9 18.0 49.4 0.1 -7.0 -2.1
Number of incorrect matches in round 1.7 2.9 8.1 -2.8 -0.3 -0.7
Past tobacco smoking 2.3 4.2 8.3 -1.5 2.9 1.4
Alcohol usually taken with meals 2.2 3.5 8.7 -1.3 3.0 0.4
Nervous feelings 4.9 9.1 19.9 0.5 4.5 2.7
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 1.8 1.4 -0.6 0.7
Hearing difficulty/problems with background noise 0.1 0.1 0.3 0.1 -0.5 0.3
Hair/balding pattern: Pattern 2 1.0 1.3 3.8 -0.4 -0.1 -1.9
Had menopause 1.1 1.4 3.2 -0.6 1.8 0.7
Had other major operations 1.1 1.3 3.3 -0.8 -0.0 -1.8
Forced vital capacity (FVC) 0.1 0.2 0.6 -0.2 0.7 -0.0
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.9 2.6 0.3 -1.6 -0.1
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 0.8 0.0 -0.4 -0.9
Qualifications: None of the above 0.6 1.3 3.5 -0.5 0.5 1.9
Financial difficulties in last 2 years 2.2 3.0 7.5 0.7 -2.7 -1.0
Mouth/teeth dental problems 1.4 2.2 6.3 0.3 2.5 0.3
Heart attack 0.4 0.5 0.9 0.4 -0.9 -0.6
Allergy 0.3 0.7 1.0 -1.0 0.7 0.7
Pain all over the body in last month 3.3 3.5 6.9 0.6 2.6 1.8
Diabetes (self-reported) 1.4 2.2 3.5 1.9 -0.9 1.5
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 1.0 1.0 0.7 1.0
Medication: Ramipril 0.6 0.8 2.3 0.2 -1.5 -0.1
Medication: Simvastatin 0.6 0.8 2.3 -1.5 -0.4 -0.1
Fluid intelligence score 0.2 0.5 0.8 -0.9 -0.3 -0.7
Illnesses of siblings 1.1 1.5 3.8 -0.8 1.9 0.3
Neuroticism score 0.2 0.4 0.6 0.3 0.7 0.8
Weight 4.0 19.8 54.3 -0.9 -7.4 -2.0
Impedance of arm (right) 1.0 4.5 10.6 0.2 3.2 -1.7
Arm fat percentage (right) 4.1 16.2 41.1 -0.7 -6.4 -2.6
Trunk fat-free mass 1.5 8.8 24.9 -1.2 -5.0 -0.4
Hip circumference 2.3 9.8 26.4 -0.7 -5.1 -1.6
Time employed in main current job 0.3 0.3 0.9 0.2 0.9 0.1
Alcohol intake versus 10 years previously 2.6 4.0 8.0 -0.0 -2.8 -2.0
Father’s age at death 1.4 1.9 4.7 0.2 2.2 1.0
Worrier / anxious feelings 1.4 2.6 5.6 0.9 2.4 1.1
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 1.4 -0.0 -1.2 -1.0
Falls in the last year 1.6 2.2 2.9 -1.7 -1.1 -1.6
Hair/balding pattern: Pattern 3 0.6 0.9 1.5 1.2 -1.1 0.3
Number of live births 1.5 2.1 3.1 0.8 1.8 1.6
Forced expiratory volume in 1-second (FEV1) 0.0 0.1 0.2 -0.0 0.5 0.4
Pulse rate 0.6 1.1 1.6 -1.2 -1.3 -0.2
Happiness 0.1 0.1 0.2 0.4 -0.3 -0.2
Noisy workplace 0.1 0.1 0.3 0.1 -0.6 -0.3
Qualifications: A levels/AS levels or equivalent 0.4 0.8 1.2 -0.8 -0.8 -1.1
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 2.7 0.3 -1.6 -0.0
Mouth/teeth dental problems: Dentures 1.1 1.9 5.0 -0.7 -2.2 -0.5
Asthma 0.4 0.9 1.7 -0.5 -0.8 -1.3
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 1.2 -1.1 -0.8 -0.5
Medication: Cholesterol lowering 0.1 0.1 0.3 -0.6 0.1 0.0
Depression (self-reported) 1.5 1.8 2.6 1.6 -0.6 1.6
Medication: Lansoprazole 2.9 3.3 7.4 -1.5 0.5 -2.7
Prospective memory result 0.9 1.1 2.5 0.0 -1.0 -1.6
Lung cancer (father) 0.1 0.1 0.2 0.3 0.1 -0.4
Illnesses of mother 0.9 1.1 2.6 -0.3 -1.6 0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 0.9 0.5 0.8 0.9
Pulse wave Arterial Stiffness index 2.3 2.7 4.5 2.1 -0.3 1.9
Impedance of arm (left) 1.3 6.2 17.1 0.5 4.1 -1.2
Arm fat mass (right) 4.5 18.7 50.4 -0.7 -7.1 -2.3
Trunk predicted mass 1.6 8.9 25.0 -1.2 -5.0 -0.5
Standing height 0.2 1.5 3.0 -0.5 -1.7 -1.1
Length of working week for main job 1.3 1.5 3.4 0.9 -1.9 0.3
Exposure to tobacco smoke at home 1.9 2.1 5.3 2.3 0.4 0.9
Breastfed as a baby 1.6 2.0 5.9 -2.4 -0.3 -0.1
Tense / ‘highly strung’ 0.6 1.0 3.1 0.0 1.8 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 2.7 1.6 0.3 1.3
Hair/balding pattern: Pattern 4 0.4 1.0 1.5 0.3 -1.2 1.2
Birth weight of first child 1.5 2.6 7.4 0.5 -2.7 -0.6
Peak expiratory flow (PEF) 0.0 0.1 0.2 0.3 -0.5 -0.1
Pulse wave reflection index 2.0 2.5 4.0 2.0 1.0 1.6
Ever highly irritable/argumentative for 2 days 0.3 0.4 0.9 1.0 -0.4 0.4
Loud music exposure frequency 0.9 1.0 2.6 1.6 -0.2 0.6
Qualifications: O levels/GCSEs or equivalent 0.3 0.4 0.9 -0.1 -0.6 -0.9
Mouth/teeth dental problems: Bleeding gums 4.4 5.7 13.1 1.7 -3.6 -1.1
Blood clot in the leg (DVT) 0.4 0.5 1.0 0.5 -0.6 -1.0
Medication: Paracetamol 0.3 0.5 1.2 0.6 -1.1 0.1
Headache pain in last month 0.4 0.8 1.9 -0.4 1.4 0.4
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 1.2 0.8 0.3 1.1
Glaucoma (self-reported) 1.9 2.2 4.8 -1.2 -2.2 -0.7
Gout (self-reported) 0.3 0.4 0.6 -0.3 -0.6 0.8
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.6 0.8 -0.6 -0.4
Medication: Amlodipine 1.1 1.5 2.3 -1.2 -0.9 -1.5
Medication: Ventolin 100micrograms inhaler 3.4 4.4 9.9 -1.2 -1.3 -3.2
Birth weight 0.7 1.6 2.6 -1.6 -1.1 -1.0
Chronic bronchitis/emphysema (mother) 1.3 1.5 2.8 -1.2 -1.7 -0.3
High blood pressure (siblings) 1.0 1.4 4.2 0.0 -2.0 -0.4
Forced vital capacity (FVC), Best measure 0.1 0.4 0.8 0.4 0.9 0.3
Body fat percentage 4.6 18.3 47.1 -0.3 -6.9 -2.8
Leg fat percentage (right) 4.8 17.4 47.7 0.2 -6.9 -2.1
Arm fat-free mass (right) 2.2 11.5 33.5 -0.8 -5.8 -0.4
Exposure to tobacco smoke outside home 1.5 2.0 2.7 1.6 -1.5 0.9
Comparative body size at age 10 0.6 1.6 4.0 0.2 -2.0 0.8
Number of full brothers 0.5 0.6 1.4 1.2 -0.4 0.3
Worry too long after embarrassment 0.9 1.5 3.8 -0.8 2.0 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.7 -0.4 0.1 -0.8
Wheeze or whistling in the chest in last year 2.1 3.7 8.4 0.3 -2.9 -1.6
Number of children fathered 1.4 1.6 2.4 -0.3 1.5 1.6
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 2.8 -0.2 1.7 0.0
Age at first live birth 0.2 0.3 0.4 -0.6 0.6 -0.3
Pulse wave peak to peak time 2.2 2.6 4.5 -2.1 0.2 -1.8
Health satisfaction 1.9 2.5 3.5 0.7 -1.9 -1.8
Shortness of breath walking on level ground 1.4 1.7 4.3 0.4 -2.1 -0.7
Qualifications: College or University degree 0.1 0.3 0.7 0.1 0.3 -0.9
Eye problems/disorders: None of the above 0.3 0.4 1.1 0.3 1.1 0.0
Mouth/teeth dental problems: Loose teeth 1.6 1.9 3.9 -1.0 -2.0 -0.8
Emphysema/chronic bronchitis 0.8 0.9 2.1 0.6 -1.5 -0.3
Medication for pain relief, constipation, heartburn 0.8 1.3 2.0 -1.4 1.4 -0.3
Neck or shoulder pain in last month 1.0 1.4 3.1 -0.2 -1.8 -1.1
Medication: Blood pressure 1.3 2.3 3.2 -1.2 -1.5 -1.8
Angina (self-reported) 0.8 1.0 2.3 1.5 -0.4 0.8
Migraine (self-reported) 1.0 1.3 2.1 0.7 1.5 1.1
Medication: Ibuprofen 0.0 0.0 0.0 -0.1 0.0 -0.2
Medication: Allopurinol 0.3 0.4 0.6 0.3 -0.7 0.8
Medication: Omeprazole 0.5 0.6 1.2 0.3 -0.6 -1.1
Medication: Seretide 50 evohaler 0.5 0.5 1.1 -1.1 0.3 -0.6
Mean time to correctly identify matches 8.3 15.8 26.1 1.5 5.1 4.4
Heart disease (mother) 0.2 0.2 0.4 0.7 0.4 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 1.6 -1.1 1.3 -0.3
Whole body fat mass 5.1 21.4 57.2 -0.5 -7.6 -2.6
Leg fat mass (right) 5.9 23.0 63.2 -0.1 -8.0 -2.4
Arm predicted mass (right) 2.2 11.5 33.9 -0.6 -5.8 -0.4
Pulse rate, automated reading 0.7 2.2 6.0 -0.3 -2.5 -0.8
Alcohol intake frequency. 0.4 0.9 1.6 -1.3 -0.7 -0.7
Comparative height size at age 10 0.5 2.9 5.4 -0.6 -2.3 -1.7
Number of full sisters 0.9 1.1 2.2 -0.7 -0.8 -1.5
Suffer from ‘nerves’ 2.0 3.1 6.1 0.8 2.5 1.6
Overall health rating 0.2 0.5 1.0 1.0 -0.4 -0.6
Chest pain or discomfort 0.2 0.2 0.5 0.2 0.4 -0.7
Had major operations 2.7 3.1 6.8 0.1 -2.6 -1.6
Age at last live birth 0.0 0.0 0.0 0.1 0.1 -0.2
Family relationship satisfaction 1.5 1.8 4.5 0.3 -2.1 -0.9
Leg pain on walking 2.0 2.5 3.1 -1.6 -1.8 -1.4
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 0.8 0.9 -0.5 0.3
Commuting to job workplace: Car/motor vehicle 0.5 0.6 1.8 -1.3 -0.1 -0.2
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 3.7 0.1 1.9 0.0
Medication: Aspirin 0.3 0.4 0.6 0.8 -0.6 0.6
Supplements: Vitamin C 0.8 0.9 2.2 -0.8 1.5 -0.1
Knee pain experienced in last month 0.2 0.3 0.6 0.3 -0.3 -0.8
Hypertension (Self-reported) 0.6 1.7 4.1 -0.7 -2.0 -0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.0 1.7 -1.3 0.1 -1.1
Illnesses of father: Heart disease 0.3 0.4 0.7 -0.8 0.5 -0.4
Illnesses of siblings: Diabetes 1.3 1.5 2.1 1.4 -1.5 -0.6
Smoking status: Previous 1.2 1.8 2.9 1.7 -1.3 -0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.6 4.8 0.1 -0.4 -2.2
Whole body fat-free mass 2.0 11.6 32.5 -1.3 -5.7 -0.8
Leg fat-free mass (right) 2.0 10.6 28.4 -1.4 -5.3 -1.1
Arm fat percentage (left) 3.6 14.2 37.2 -0.5 -6.1 -2.3
Average weekly red wine intake 1.4 2.1 4.4 -0.1 2.1 1.4
Handedness (chirality/laterality): Left-handed 0.5 0.6 0.8 0.9 -0.7 -0.7
Mood swings 0.8 1.5 2.3 1.5 -0.7 1.4
Loneliness, isolation 0.2 0.3 0.8 0.4 0.9 0.3
Long-standing illness, disability or infirmity 0.8 1.2 2.7 0.3 -1.6 -0.8
Ever had bowel cancer screening 0.1 0.1 0.2 -0.5 0.4 0.2
Diabetes diagnosed by doctor 0.8 1.3 2.0 1.4 -1.0 0.9
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 2.3 0.5 -1.5 -0.6
Friendships satisfaction 0.2 0.2 0.3 0.6 -0.2 -0.5
Qualifications: nursing, teaching 0.2 0.4 0.5 0.7 -0.4 -0.7
Commuting to job workplace: Walk 1.2 1.3 3.2 0.8 -1.8 0.2
Eye problems/disorders: Cataract 0.3 0.4 1.1 -0.1 -1.1 -0.2
Mouth/teeth dental problems: Mouth ulcers 1.4 2.3 3.4 -1.0 1.5 1.8
Medication for cholesterol 0.4 0.7 1.8 0.4 -0.1 -1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 0.8 0.9 -0.7 -0.7
Back pain experienced in last month 1.4 2.0 3.4 -1.1 -1.1 -1.8
Mineral and other dietary supplements 3.0 4.0 8.2 -1.8 -0.8 -2.9
Breast cancer (self-reported) 1.3 1.6 2.5 -0.2 1.6 -1.5
Asthma (self-reported) 0.4 0.9 1.8 -0.6 -0.7 -1.4
Osteoporosis (self-reported) 0.4 0.5 1.5 -0.1 1.2 0.3
Osteoarthritis (self-reported) 0.2 0.3 0.5 0.7 -0.6 0.2
Medication: Aspirin 0.8 1.1 1.8 1.4 -0.5 1.1
Medication: Gliclazide 0.5 0.6 1.3 0.4 -1.1 -0.5
Illnesses of father: None of the above (group 1) 0.9 1.2 2.6 1.6 0.7 0.6
Smoking status: Current 3.7 5.9 17.1 0.5 -4.1 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 1.2 -0.6 1.1 1.0
Whole body water mass 1.9 10.6 29.9 -1.2 -5.5 -0.6
Leg predicted mass (right) 1.9 10.2 27.6 -1.5 -5.2 -1.0
Arm fat mass (left) 4.5 18.5 50.4 -0.6 -7.1 -2.2
Number of self-reported non-cancer illnesses 0.5 0.8 2.0 -0.0 -1.4 -0.7
Average weekly champagne plus white wine intake 0.9 1.3 2.4 -0.6 1.5 1.0
Miserableness 2.4 4.2 7.1 2.3 -2.7 0.3
Guilty feelings 1.0 1.4 2.6 -1.1 -1.6 -0.8
Wears glasses or contact lenses 0.3 0.3 0.8 -0.1 0.3 0.9
Ever taken oral contraceptive pill 1.1 1.2 1.8 0.0 -1.4 -1.3
Hearing aid user 0.8 0.9 2.0 -0.6 -1.4 -0.6
Mother’s age at death 0.1 0.1 0.3 -0.5 0.3 -0.0
Financial situation satisfaction 2.9 3.6 7.1 1.9 -2.7 -0.5
Tinnitus: Yes, now most or all of the time 0.8 1.0 2.5 1.6 -0.2 0.7
Commuting to job workplace: Public transport 1.7 2.1 2.6 1.4 -1.3 -1.6
Eye problems/disorders: Glaucoma 2.9 3.5 9.4 -0.8 -3.1 -0.7
Medication: Blood pressure 0.7 1.3 2.9 -1.1 -1.7 -0.0
Pain type(s) experienced in last month: Hip pain 0.3 0.4 0.6 0.7 -0.8 0.2
Supplements: Fish oil (including cod liver oil) 2.9 3.8 6.8 1.6 1.4 2.6
High cholesterol (Self-reported) 0.3 0.5 1.0 -0.5 0.4 1.0
Medication: Bendroflumethiazide 0.6 0.9 2.3 -0.5 -1.5 -0.3
Medication: Paracetamol 0.9 1.4 2.8 1.7 -0.5 1.1
Medication: Lisinopril 0.9 1.2 1.8 -0.8 -1.3 -1.0
Medication: Atorvastatin 0.9 1.1 1.8 0.4 1.4 1.1
Illnesses of father: High blood pressure 0.6 0.8 1.7 -0.6 -1.3 0.5
Alcohol drinker status: Never 3.4 4.0 7.3 -2.7 1.2 -1.8
Ever smoked 2.3 4.1 7.9 1.6 -2.8 -1.4
Basal metabolic rate 2.6 14.4 40.1 -1.3 -6.3 -1.3
Leg fat percentage (left) 4.5 16.1 44.4 -0.2 -6.7 -2.0
Arm fat-free mass (left) 2.6 13.0 37.2 -1.1 -6.1 -0.8
Number of operations (self-reported) 0.9 1.3 2.9 0.2 -1.0 -1.7
Average weekly beer plus cider intake 2.4 3.4 8.6 0.6 -2.9 -1.1
Irritability 2.3 4.0 8.1 2.0 -2.8 0.1
Risk taking 0.5 0.7 1.0 1.0 -0.8 0.7
Ever had prostate specific antigen (PSA) test 2.3 2.6 4.3 0.1 2.1 1.9
Fractured/broken bones in last 5 years 0.2 0.3 0.6 -0.2 0.8 -0.4
Age started oral contraceptive pill 0.3 0.3 0.7 -0.9 -0.4 -0.3
Diastolic blood pressure, automated reading 1.7 5.4 13.4 -1.5 -3.7 -0.7
Ever depressed for a whole week 0.2 0.2 0.4 -0.2 -0.4 -0.7
Unable to work because of sickness or disability 0.7 0.9 1.2 1.1 0.6 1.1
Commuting to job workplace: Cycle 0.6 0.7 0.8 0.9 -0.8 0.8
Myopia 2.4 3.5 9.5 -0.1 -3.1 -1.0
Vascular/heart problems diagnosed by doctor 0.4 1.1 3.0 0.4 1.7 0.3
Cholesterol lowering medication 0.2 0.2 0.5 -0.4 -0.3 0.7
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 1.7 0.5 -0.5 -1.3
Pain experienced in last month 0.2 0.3 0.9 -0.2 -0.2 -0.9
Supplements: Calcium 3.0 3.3 5.7 1.3 1.6 2.4
Basal cell carcinoma (self-reported) 0.5 0.5 1.4 0.2 -1.2 0.4
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.8 0.3 -0.9 -0.7
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 1.5 0.6 -0.4 -1.2
Heart disease (siblings) 0.1 0.1 0.2 0.4 0.5 0.2
Alcohol drinker status: Previous 1.1 1.3 2.2 -1.2 -1.5 0.4
Pack years of smoking 3.6 5.3 16.0 0.2 -4.0 0.0
Impedance of whole body 0.9 4.8 11.4 0.9 3.4 -1.5
Leg fat mass (left) 5.6 21.7 59.8 -0.2 -7.7 -2.3
Arm predicted mass (left) 2.4 12.4 35.2 -1.1 -5.9 -0.9