Hub : Genes

AHR

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1990	0.0580	4.3e-04	0.188	NA	0.144	NA	0.180	4.3e-14	NA	6.7e-11	NA	1.8e-13
2	GTEx	Pancreas	0.2260	0.0780	1.9e-03	0.018	NA	0.033	NA	0.047	5.7e-02	NA	1.5e-02	NA	4.6e-03
3	GTEx	Testis	0.2390	0.0880	5.9e-03	0.017	NA	-0.006	NA	0.002	5.5e-02	NA	9.3e-01	NA	2.6e-01
4	TCGA	Breast Invasive Carcinoma	0.0148	0.0085	1.2e-03	0.012	0.010	0.005	NA	0.008	1.1e-03	3.1e-03	2.3e-02	NA	8.8e-03
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0956	0.0367	1.2e-10	0.088	0.108	0.117	NA	0.118	3.8e-10	4.0e-12	4.8e-13	NA	3.7e-13

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.2	0.3	0.8	-0.9	0.2	-0.7	0.2	-0.1
Bipolar Disorder or Schizophrenia	0.4	0.9	1.6	-0.3	-1.1	-1.3	0.6	-1.0
Depressed Affect (Nagel 2018)	1.1	2.3	5.6	-0.9	2.4	-0.7	-1.6	1.4
Depression (Nagel 2018)	0.5	0.8	1.9	-1.4	-0.2	-1.3	-0.4	-0.1
Intelligence (Savage-Jansen 2018)	0.6	1.7	4.7	-2.2	0.2	-0.0	1.5	-1.3
Neuroticism (Nagel 2018)	1.0	2.3	5.7	-1.2	2.4	-1.2	-1.2	1.1
Schizophrenia (2018)	0.5	1.1	2.5	0.4	-1.6	-1.0	0.6	-1.2
Schizophrenia vs Biploar Disorder	0.4	0.5	2.1	1.5	-0.6	0.1	0.2	-0.2
Worry (Nagel 2018)	1.2	2.6	5.8	-2.4	1.9	-1.5	-0.7	0.9
Alzheimer’s Disease (in mother)	1.0	1.2	3.0	1.0	-1.7	0.3	0.7	-1.2
Alzheimer’s Disease (in father)	2.7	3.0	5.5	-0.7	-2.1	-0.7	2.0	-2.3
Alzheimer’s Disease (including proxy)	0.7	1.0	2.4	0.1	-1.6	0.3	1.0	-1.3
Crohns Disease (2017)	0.0	0.1	0.2	-0.3	0.1	0.3	-0.5	-0.1
Irritable Bowel Disease (IBD)	1.6	3.8	10.8	0.6	1.2	3.3	-2.0	1.5
Ulcerative Colitis (UC)	4.4	8.3	21.8	1.2	2.1	4.7	-2.8	2.4
Major Depression (MDD)	0.4	0.5	1.3	-1.2	0.9	-0.4	0.2	0.4
Reaction Time	1.2	2.3	5.0	-2.2	2.0	-0.7	-1.4	0.1
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.4	-0.6	-0.1	0.1	0.6	-0.6
Breast Cancer	0.1	0.2	0.6	-0.8	0.4	0.3	-0.1	-0.2
Ovarian Cancer	0.7	0.9	2.2	-0.3	0.5	-0.1	-1.4	1.5
Prostate Cancer	0.5	0.6	1.8	-0.2	-0.6	-0.3	0.9	-1.3
Age at First Birth	0.4	0.6	1.6	1.2	1.1	-0.5	0.1	-0.4
Bipolar Disorder (2011)	1.3	1.2	5.2	-0.1	2.3	0.9	0.0	0.0
Body Mass Index (BMI) (2010)	0.7	1.0	1.6	-1.0	0.7	0.9	-1.2	0.9
Coronary Artery Disease (CAD)	0.5	0.6	1.7	-1.3	-0.9	0.1	-0.2	-0.5
Crohns Disease (2012)	0.4	0.6	2.2	-1.5	-0.5	0.1	-0.7	-0.1
Mean Putamen Volume	0.7	0.8	2.0	1.3	1.4	0.4	-0.5	0.1
Fasting Glucose	0.1	0.1	0.2	-0.4	0.5	-0.5	-0.3	0.1
HbA1C	0.9	1.0	1.8	-0.1	0.9	-1.3	0.9	-1.3
HDL Cholesterol	0.8	1.4	3.9	1.4	0.0	-0.8	2.0	-0.5
LDL Cholesterol	0.2	0.4	1.8	-0.1	-0.2	-0.3	-1.4	-0.1
Lupus	2.3	3.5	8.0	-2.8	2.2	0.3	-1.7	1.3
Neuroticism (2016)	0.6	0.8	1.8	0.6	1.4	-1.2	-0.7	0.5
Primary Biliary Cirrhosis	0.4	0.5	1.3	0.8	1.1	0.2	-0.4	0.7
Rheumatoid Arthritis	2.0	2.8	8.8	-0.2	1.1	1.2	-3.0	1.5
Schizophrenia (2014)	0.4	1.0	1.7	0.7	-1.3	-1.0	0.7	-1.1
Triglycerides	0.6	0.9	1.7	-1.3	-0.4	-1.2	0.1	-1.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.1	-1.0	-0.2	-1.5	-0.4	0.6
Ulcerative Colitis	3.0	4.3	10.2	1.0	0.9	3.2	-2.2	2.2
Blood Eosinophil Count	0.2	1.8	5.2	-0.2	0.1	1.6	-1.0	2.3
Blood Platelet Count	0.4	4.8	13.8	-2.5	0.8	0.3	-3.7	1.7
Blood Red Count	0.1	1.1	3.0	0.5	-0.6	-1.7	0.9	-1.0
Blood White Count	0.1	0.4	1.3	-0.2	-1.2	-0.4	-0.0	0.6
Heel T-Score	0.2	1.2	2.9	-1.2	0.2	0.7	-1.1	1.7
BMI	0.8	4.9	12.2	0.8	2.9	0.6	-3.5	1.6
Height	0.5	10.4	22.0	2.5	-1.2	-0.8	4.7	-4.7
Waist Hip Ratio (WHR)	0.3	1.4	5.7	2.4	0.5	0.8	0.4	0.4
Systolic Blood Pressure	0.3	1.3	3.1	-0.9	1.5	-0.2	-1.8	0.8
Smoking Status	0.9	2.1	5.7	0.9	-1.2	-0.8	2.4	-1.4
Allergy or Eczema	0.2	0.6	1.4	0.4	-1.2	-1.0	0.6	0.0
Cardiovascular Disease	0.4	1.3	3.7	-0.2	1.0	-1.3	-1.9	0.5
Hypothyroidism (self reported)	0.5	1.2	2.9	0.9	0.9	0.5	-1.7	1.1
Respiratory disease	0.1	0.2	0.4	0.3	0.3	0.4	0.6	-0.3
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.7	-0.3	-0.9	-0.8	0.2	-1.3
Lung FEV1/FVC ratio	0.2	1.0	1.8	-1.2	-0.0	-1.4	-1.3	-0.2
Lung FVC	0.2	1.1	2.9	-1.6	-1.7	0.2	0.5	0.2
Neuroticism	0.8	2.0	4.3	-1.6	2.1	-1.6	-0.5	0.5
Chronotype (morning person)	0.6	1.4	4.3	-2.1	-0.6	-0.9	0.1	1.2
Hair Pigment	0.1	3.3	10.2	0.2	1.7	0.3	-3.2	1.8
Tanning	1.9	22.8	40.6	-1.4	-5.3	-2.5	6.1	-6.4
Hand grip strength (left)	0.7	1.8	5.0	-0.2	-1.6	0.7	2.2	-0.9
Number of treatments/medications taken	0.6	1.1	3.8	-0.2	2.0	-0.2	-1.1	0.5
Average weekly spirits intake	0.1	0.2	0.5	0.0	0.7	0.5	0.0	0.2
Sensitivity / hurt feelings	0.5	0.9	1.8	-0.5	1.3	0.0	-1.2	1.0
Frequency of depressed mood in last 2 weeks	1.5	2.0	4.2	-1.4	1.2	0.4	-2.1	1.5
Hearing difficulty/problems: Yes	0.9	1.4	2.2	-1.4	1.4	0.1	-1.1	1.5
Relative age of first facial hair	1.0	2.1	3.2	0.3	-1.8	-1.3	1.8	-1.6
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.4	1.2	1.1	-0.6	-0.4	-0.2
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.7	0.0	1.6	0.6	-0.1	-0.2
Ever had hysterectomy (womb removed)	0.5	0.5	1.3	-1.1	1.1	0.1	0.3	0.1
Systolic blood pressure, automated reading	0.8	2.4	3.9	-1.8	2.0	-0.1	-1.8	1.2
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	0.6	0.6	0.4	-0.1	0.2
Angina	2.6	3.4	5.3	1.5	2.0	1.6	-2.3	1.6
Medication for hormone replacement therapy	0.4	0.5	1.8	0.0	1.4	0.2	0.0	0.7
Vitamin and mineral supplements	0.3	0.4	0.9	-0.4	-0.0	-0.9	-1.0	0.5
Supplements: Zinc	2.3	2.5	3.6	0.8	-1.8	-1.3	1.9	-1.8
Medication: Co-codamol	1.8	2.1	4.0	-0.3	1.9	0.9	-2.0	1.4
Medication: Metformin	0.2	0.3	0.5	-0.6	0.6	-0.6	-0.1	-0.7
Diabetes (father)	2.1	2.6	4.8	0.8	-2.2	-0.7	1.8	-2.0
Diabetes (mother)	0.2	0.3	0.7	-0.6	-0.2	0.1	-0.8	0.6
Severe depression (siblings)	0.3	0.4	1.1	-0.5	-1.0	-0.3	-0.4	-0.5
Pack years adult smoking proportion	2.6	3.9	8.6	1.2	2.9	1.6	-1.6	2.1
Impedance of leg (right)	0.1	0.5	1.2	-1.1	-0.5	0.3	0.9	0.5
Leg fat-free mass (left)	0.4	2.0	6.1	1.1	-0.2	-1.2	1.1	-2.5
Trunk fat percentage	0.4	1.5	4.7	0.2	2.2	-0.8	-1.4	0.2
Hand grip strength (right)	1.5	4.1	11.0	0.7	-2.4	-0.4	3.3	-1.7
Townsend deprivation index at recruitment	0.4	0.6	1.4	1.2	-0.1	0.5	0.7	-1.0
Current tobacco smoking	1.6	2.6	4.2	0.1	-2.0	-1.9	1.6	-1.7
Average weekly fortified wine intake	0.3	0.3	0.5	0.7	0.4	-0.4	-0.3	0.7
Maternal smoking around birth	0.5	0.7	2.0	0.4	0.1	1.1	-0.4	1.4
Fed-up feelings	0.7	1.3	2.7	-0.4	1.5	0.6	-1.6	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	2.6	-1.6	-1.6	-1.6	0.9	-1.2
Relative age voice broke	1.2	1.8	4.0	-0.3	-1.8	-0.3	1.3	-2.0
Taking other prescription medications	1.1	1.6	4.6	-0.9	2.2	-0.1	-1.3	1.0
Age when periods started (menarche)	0.2	0.4	0.9	1.0	-0.1	0.2	1.0	-0.1
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	2.8	-0.4	1.2	1.7	-0.9	1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.3	-0.7	0.4	1.2	-0.8	0.8
Tinnitus: Yes, but not now, but have in the past	3.0	3.2	5.8	-0.5	1.8	-1.8	-2.0	2.4
Qualifications: CSEs or equivalent	0.7	0.9	3.8	2.0	-0.2	0.5	-0.2	0.5
Serious illness, injury or assault to yourself	2.4	2.9	6.4	-0.4	1.2	0.9	-2.4	2.5
High blood pressure	0.6	1.6	5.0	-1.2	0.5	-0.8	-2.2	0.6
Hayfever, allergic rhinitis or eczema	0.9	2.0	4.9	1.4	-2.2	-0.6	1.3	-1.1
Multivitamins +/- minerals	0.4	0.5	1.2	0.1	1.0	1.1	-0.6	0.5
Stomach or abdominal pain in last month	0.4	0.5	1.4	1.2	0.1	0.9	0.3	-0.6
Supplements: Glucosamine	0.2	0.3	0.7	-0.0	-0.5	0.3	-0.8	0.6
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.0	1.0	-0.4	0.1	-0.7	0.2
Medication: Atenolol	1.9	2.4	4.4	0.1	2.1	1.6	-1.8	1.2
Medication: Levothyroxine sodium	1.2	2.1	3.6	1.6	1.0	0.6	-1.8	1.9
Sitting height	0.6	4.1	10.5	1.5	-0.4	-1.3	3.2	-2.5
Chronic bronchitis/emphysema (father)	0.3	0.3	0.7	0.6	0.6	-0.8	0.0	0.3
High blood pressure (mother)	1.5	2.1	4.1	0.9	1.6	0.2	-1.7	2.0
Body mass index (BMI)	0.8	3.2	8.0	0.5	2.5	-0.4	-2.8	1.1
Impedance of leg (left)	0.1	0.3	0.8	-0.3	-0.2	0.7	0.5	0.9
Leg predicted mass (left)	0.4	2.2	6.4	1.2	-0.1	-1.2	1.1	-2.5
Trunk fat mass	0.3	1.3	3.6	0.7	1.9	-0.9	-1.1	-0.4
Waist circumference	0.8	2.8	8.5	1.3	2.9	-0.0	-1.9	0.7
Number of incorrect matches in round	0.5	0.9	2.2	-1.5	1.1	-0.2	0.8	-0.4
Past tobacco smoking	0.7	1.3	3.1	-1.8	0.8	-0.3	-1.6	0.3
Alcohol usually taken with meals	0.7	1.2	3.4	0.5	0.4	-1.3	1.9	-0.7
Nervous feelings	0.7	1.3	3.5	-1.5	1.9	-0.3	-0.5	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.7	0.2	0.8	-0.3	-0.0	-0.3
Hearing difficulty/problems with background noise	1.0	1.6	6.7	-2.6	0.7	-0.7	0.3	0.1
Hair/balding pattern: Pattern 2	1.0	1.2	2.7	0.8	-1.1	-0.6	1.7	-1.0
Had menopause	0.9	1.1	2.3	-0.7	1.4	0.4	-1.5	0.8
Had other major operations	1.9	2.4	4.0	-2.0	1.7	1.4	-1.1	1.2
Forced vital capacity (FVC)	1.2	4.8	13.5	0.3	-2.6	-0.5	3.7	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.2	-0.2	0.7	1.2	-1.1	1.5
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.1	-0.4	-0.1	0.2	-0.4	-0.2
Qualifications: None of the above	2.0	4.4	13.0	-0.4	3.6	1.1	-1.0	2.6
Financial difficulties in last 2 years	0.4	0.5	1.4	1.2	0.7	-0.2	-0.7	0.2
Mouth/teeth dental problems	1.6	2.5	4.8	0.4	-1.7	-0.6	2.0	-2.2
Heart attack	0.4	0.5	1.3	1.1	0.6	-0.7	0.3	0.2
Allergy	0.7	1.5	2.8	-1.3	1.6	-0.1	-1.7	0.8
Pain all over the body in last month	0.3	0.3	0.6	0.6	-0.5	-0.6	-0.2	-0.8
Diabetes (self-reported)	0.2	0.3	1.1	0.3	0.2	-0.6	-0.4	-1.0
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	4.0	2.0	-0.1	-0.1	-0.1	-0.0
Medication: Ramipril	1.0	1.3	3.7	-0.4	0.7	-1.5	-1.9	0.3
Medication: Simvastatin	0.9	1.3	4.2	0.0	1.1	-0.4	-2.0	0.9
Fluid intelligence score	0.6	1.3	4.0	-2.0	-0.6	-0.9	0.8	-1.0
Illnesses of siblings	0.6	0.8	1.3	1.1	-1.0	0.0	0.9	-0.9
Neuroticism score	0.9	1.8	4.8	-1.5	2.2	-0.3	-1.1	0.7
Weight	0.2	1.2	2.8	1.3	1.7	-0.7	-0.7	-0.7
Impedance of arm (right)	1.0	4.9	9.8	-0.8	-2.5	-1.3	3.1	-2.4
Arm fat percentage (right)	0.3	1.1	2.0	0.4	1.3	-1.4	-1.3	-0.4
Trunk fat-free mass	0.3	1.7	3.9	1.7	-0.7	-0.6	1.1	-2.0
Hip circumference	0.3	1.2	3.9	-0.0	2.0	-0.8	-1.0	-0.5
Time employed in main current job	1.6	1.9	5.7	-0.4	0.9	2.4	-1.0	1.2
Alcohol intake versus 10 years previously	0.9	1.3	2.8	0.5	-0.5	-0.7	1.7	-1.6
Father’s age at death	0.3	0.4	0.7	0.8	0.8	-0.8	0.1	-0.3
Worrier / anxious feelings	0.3	0.6	1.3	-0.5	0.9	0.4	-0.8	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.8	-0.6	0.5	-0.5	-0.9	0.2
Falls in the last year	0.5	0.7	1.7	1.3	-0.0	-0.9	-0.5	-0.7
Hair/balding pattern: Pattern 3	2.1	3.2	8.8	-1.2	1.1	1.4	-3.0	1.5
Number of live births	0.2	0.3	0.8	-0.5	0.9	-0.2	-0.5	0.5
Forced expiratory volume in 1-second (FEV1)	1.4	4.6	9.5	-0.2	-3.0	-1.0	3.1	-1.9
Pulse rate	0.7	1.1	1.9	1.4	-0.5	-0.8	1.0	-1.4
Happiness	0.4	0.4	1.8	-1.3	0.1	-0.6	-0.2	0.0
Noisy workplace	1.5	1.8	2.8	-0.7	1.7	1.1	-1.7	1.4
Qualifications: A levels/AS levels or equivalent	1.2	2.6	4.9	-1.3	-2.2	-1.2	1.3	-1.9
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.4	1.5	0.0	0.7	-0.4	1.0
Mouth/teeth dental problems: Dentures	0.6	1.0	2.4	0.1	1.1	0.4	-1.2	1.5
Asthma	0.1	0.2	0.3	0.6	-0.2	0.4	0.4	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	2.0	1.0	-0.9	-1.4	1.1	-0.9
Medication: Cholesterol lowering	0.1	0.2	0.4	0.6	0.3	0.1	-0.7	-0.2
Depression (self-reported)	0.5	0.6	1.6	-1.0	1.3	-0.5	0.0	0.4
Medication: Lansoprazole	1.0	1.2	4.5	0.3	0.6	0.6	-2.1	0.8
Prospective memory result	0.2	0.3	0.9	-0.4	0.3	0.9	-0.1	0.5
Lung cancer (father)	1.0	1.2	2.7	1.5	-0.1	-1.6	0.9	-0.3
Illnesses of mother	0.9	1.2	2.7	-1.6	0.5	0.3	1.4	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.5	8.8	-0.0	-2.8	-1.4	3.0	-2.1
Pulse wave Arterial Stiffness index	4.1	4.8	11.2	-1.0	-1.7	-3.4	1.6	-2.6
Impedance of arm (left)	1.0	4.5	9.4	-0.9	-2.2	-1.4	3.1	-2.3
Arm fat mass (right)	0.3	1.2	2.5	0.7	1.6	-1.3	-1.1	-0.4
Trunk predicted mass	0.3	1.8	4.1	1.7	-0.7	-0.7	1.2	-2.0
Standing height	0.9	9.2	20.0	2.2	-2.1	-1.1	4.5	-4.0
Length of working week for main job	0.3	0.3	0.5	0.5	0.6	0.7	0.7	0.1
Exposure to tobacco smoke at home	0.4	0.5	0.8	-0.0	0.9	0.1	-0.9	0.8
Breastfed as a baby	1.1	1.3	2.7	0.5	-1.6	-0.5	0.9	-1.6
Tense / ‘highly strung’	2.5	4.1	9.6	-1.7	3.1	-0.2	-2.4	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	2.7	-1.7	0.5	0.5	0.5	-0.3
Hair/balding pattern: Pattern 4	0.1	0.3	1.4	0.0	-0.4	-1.2	-0.3	-0.0
Birth weight of first child	0.4	0.7	2.0	1.4	-0.1	-0.6	-1.0	-0.1
Peak expiratory flow (PEF)	2.5	5.9	10.8	-0.0	-3.3	-1.6	2.7	-2.9
Pulse wave reflection index	0.9	1.2	2.9	-1.6	-0.6	-1.7	-0.0	-0.4
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.4	-0.6	1.2	-0.1	-1.2	0.9
Loud music exposure frequency	0.9	1.0	2.7	1.6	-1.0	-0.6	0.7	-0.8
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.1	0.5	-1.8	-0.5	0.7	-1.2
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.6	-0.2	1.1	-0.1	-1.6	0.8
Blood clot in the leg (DVT)	0.2	0.2	0.5	0.5	0.7	-0.3	0.2	-0.4
Medication: Paracetamol	0.6	0.9	1.6	1.0	0.9	0.7	-0.9	1.3
Headache pain in last month	0.3	0.6	1.0	-1.0	1.0	0.7	0.3	0.6
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	3.1	0.2	-0.7	-0.6	1.8	-0.4
Glaucoma (self-reported)	0.5	0.6	1.0	-0.1	1.0	0.5	-1.0	0.8
Gout (self-reported)	0.7	1.0	2.2	1.5	1.0	0.8	-0.7	0.6
Hypothyroidism/myxoedema (self-reported)	1.2	2.4	4.8	0.5	1.2	1.3	-2.2	2.0
Medication: Amlodipine	0.1	0.2	0.6	0.3	-0.2	-0.5	-0.7	-0.2
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.9	0.9	-0.5	-0.7	1.4	-0.2
Birth weight	1.0	2.2	3.5	1.9	0.8	-1.2	1.5	-1.8
Chronic bronchitis/emphysema (mother)	2.8	3.2	7.7	-0.7	0.9	1.6	-2.8	2.1
High blood pressure (siblings)	0.8	1.1	3.1	-0.7	1.8	0.2	-1.3	0.7
Forced vital capacity (FVC), Best measure	1.4	5.2	13.4	0.2	-2.6	-1.3	3.7	-2.1
Body fat percentage	0.5	1.9	5.1	0.4	2.3	-0.6	-1.9	0.5
Leg fat percentage (right)	1.1	3.8	8.3	-0.0	2.9	-0.0	-2.7	1.8
Arm fat-free mass (right)	0.2	0.9	2.6	1.6	0.9	0.4	-0.2	-0.8
Exposure to tobacco smoke outside home	1.7	2.3	6.3	-1.9	1.3	2.5	0.2	0.0
Comparative body size at age 10	0.3	0.9	1.9	-0.7	0.6	-0.3	-1.4	1.4
Number of full brothers	0.1	0.2	0.8	-0.1	-0.1	-0.3	0.9	-0.1
Worry too long after embarrassment	0.6	1.0	3.7	0.7	1.9	-0.5	0.4	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.4	-1.2	1.2	0.2	-1.0	0.2
Wheeze or whistling in the chest in last year	1.2	2.2	4.5	-0.7	2.1	1.2	-1.2	1.9
Number of children fathered	0.6	0.7	1.6	-1.3	-0.6	1.1	0.1	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.3	-1.0	-1.2	0.5	0.5	-0.1
Age at first live birth	0.3	0.6	2.2	1.5	-0.6	-0.5	0.1	0.4
Pulse wave peak to peak time	3.5	4.1	10.6	1.0	1.4	3.2	-1.4	2.3
Health satisfaction	1.3	1.7	3.9	1.5	2.0	0.6	-1.4	0.5
Shortness of breath walking on level ground	1.8	2.2	4.7	0.6	2.2	1.6	-1.2	1.3
Qualifications: College or University degree	1.6	5.0	10.4	0.4	-3.2	-0.7	2.2	-3.1
Eye problems/disorders: None of the above	0.4	0.5	1.4	-0.4	-0.4	-1.2	0.8	-0.3
Mouth/teeth dental problems: Loose teeth	0.8	0.9	1.3	-1.2	-0.8	-0.6	1.1	-1.0
Emphysema/chronic bronchitis	0.6	0.6	2.0	1.4	0.8	0.4	-0.5	0.3
Medication for pain relief, constipation, heartburn	0.4	0.7	2.0	-0.1	-1.4	0.3	0.7	-0.9
Neck or shoulder pain in last month	1.2	1.7	2.3	-1.2	1.5	1.1	-1.3	1.4
Medication: Blood pressure	0.9	1.6	4.9	-0.5	1.1	0.5	-2.2	1.2
Angina (self-reported)	2.1	2.8	4.2	1.3	2.0	1.5	-2.0	1.3
Migraine (self-reported)	1.0	1.2	2.6	-1.6	0.1	1.2	-1.4	0.5
Medication: Ibuprofen	1.3	1.6	3.4	1.2	-1.0	-1.9	1.2	-0.8
Medication: Allopurinol	0.6	0.8	2.8	1.7	0.5	0.6	-0.5	0.5
Medication: Omeprazole	0.8	1.0	3.0	0.8	1.7	1.0	0.4	0.1
Medication: Seretide 50 evohaler	0.8	1.0	3.0	1.7	-0.1	-0.4	1.1	0.7
Mean time to correctly identify matches	1.7	3.2	8.8	-1.3	3.0	0.3	-2.1	0.8
Heart disease (mother)	0.2	0.2	1.0	0.1	-1.0	-0.2	0.3	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.6	1.3	0.4	0.8	0.1	0.1
Whole body fat mass	0.3	1.3	3.4	0.5	1.9	-0.9	-1.4	-0.1
Leg fat mass (right)	0.4	1.6	4.1	0.8	2.0	-0.4	-1.7	0.4
Arm predicted mass (right)	0.2	0.8	2.1	1.4	0.6	-0.1	0.1	-1.2
Pulse rate, automated reading	0.2	0.8	2.4	1.0	-0.2	-0.4	0.6	-1.5
Alcohol intake frequency.	1.0	2.2	4.3	-1.8	2.1	0.5	-1.3	1.3
Comparative height size at age 10	0.2	1.1	2.9	-0.6	-0.0	0.1	1.7	-1.5
Number of full sisters	0.4	0.5	1.6	-1.3	0.3	0.5	0.3	-0.3
Suffer from ‘nerves’	1.1	1.7	4.8	-0.7	2.2	-0.9	-1.0	1.2
Overall health rating	0.6	1.2	1.7	0.3	1.2	1.3	-1.3	1.1
Chest pain or discomfort	1.3	1.9	4.6	-0.4	0.9	1.0	-1.7	2.1
Had major operations	0.3	0.3	0.7	-0.2	-0.4	-0.8	-0.7	0.5
Age at last live birth	0.2	0.3	0.9	0.6	-0.9	-0.5	0.4	0.2
Family relationship satisfaction	0.9	1.1	3.4	0.6	-0.9	-1.8	0.1	-0.9
Leg pain on walking	0.1	0.2	0.5	-0.7	-0.4	-0.3	-0.2	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.1	-1.1	0.2	0.7	-1.0	0.7
Commuting to job workplace: Car/motor vehicle	1.0	1.2	5.2	-0.5	2.3	0.1	-0.6	-0.1
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	2.6	-0.3	-1.4	-0.3	1.6	-1.6
Medication: Aspirin	0.4	0.5	1.1	0.2	0.7	-1.1	-0.9	0.4
Supplements: Vitamin C	2.5	3.0	6.7	1.6	-1.6	0.2	2.6	-1.8
Knee pain experienced in last month	1.9	2.9	4.2	-0.4	2.1	1.9	-1.6	2.0
Hypertension (Self-reported)	0.6	1.8	5.0	-1.0	1.1	-0.9	-2.2	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.9	0.1	1.7	-0.5	-0.1	-0.4
Illnesses of father: Heart disease	0.5	0.6	1.7	-0.5	-0.1	0.7	-0.9	1.3
Illnesses of siblings: Diabetes	0.1	0.2	0.4	0.1	-0.6	-0.3	-0.3	0.4
Smoking status: Previous	0.7	1.0	2.4	0.9	0.8	1.6	0.2	1.0
Forced expiratory volume in 1-second (FEV1), predicted	3.5	7.2	15.5	1.2	-2.2	-1.9	3.9	-3.3
Whole body fat-free mass	0.3	1.8	4.8	1.6	-0.4	-0.8	1.0	-2.2
Leg fat-free mass (right)	0.5	2.4	6.3	1.7	-0.2	-1.2	1.2	-2.5
Arm fat percentage (left)	0.3	1.2	2.2	0.4	1.5	-1.4	-1.4	-0.3
Average weekly red wine intake	0.7	1.0	2.7	1.3	-0.4	-1.6	0.7	-0.2
Handedness (chirality/laterality): Left-handed	2.4	2.9	5.8	-1.0	1.6	0.0	-2.4	2.2
Mood swings	1.0	1.9	4.0	-1.2	2.0	-0.1	-1.3	1.4
Loneliness, isolation	1.1	1.5	2.7	-1.5	1.6	0.3	-1.3	1.0
Long-standing illness, disability or infirmity	0.6	0.9	2.8	0.1	1.7	0.2	-1.2	0.4
Ever had bowel cancer screening	3.4	4.0	7.5	-0.5	2.7	2.1	-1.9	2.0
Diabetes diagnosed by doctor	0.1	0.2	0.6	-0.1	0.7	0.2	-0.8	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	1.0	0.1	-0.4	1.0	0.0	-0.0
Friendships satisfaction	0.4	0.5	1.3	-1.2	0.0	-1.0	-0.0	-0.3
Qualifications: nursing, teaching	2.3	3.7	12.6	-3.5	-1.5	0.6	1.1	-1.3
Commuting to job workplace: Walk	0.3	0.4	0.8	-0.5	-0.6	0.5	-0.3	0.9
Eye problems/disorders: Cataract	0.9	1.1	2.4	0.5	1.2	1.6	-0.8	0.9
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.5	-0.7	-0.2	-0.5	-0.1	0.3
Medication for cholesterol	1.2	1.8	3.6	-1.1	-1.9	1.2	1.6	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.5	1.6	0.5	0.5	0.7	-0.0
Back pain experienced in last month	0.9	1.4	2.1	-1.3	1.5	1.3	-0.9	0.6
Mineral and other dietary supplements	0.0	0.1	0.1	-0.1	-0.3	-0.4	0.1	0.1
Breast cancer (self-reported)	0.4	0.5	1.0	-0.8	0.4	-0.1	-0.9	1.0
Asthma (self-reported)	0.1	0.2	0.4	0.4	-0.2	0.6	0.4	0.2
Osteoporosis (self-reported)	1.3	1.5	3.2	-0.2	1.3	1.4	-0.8	1.8
Osteoarthritis (self-reported)	0.4	0.5	1.0	0.1	1.0	-1.0	-0.5	-0.1
Medication: Aspirin	0.5	0.6	1.2	-0.2	0.9	-0.8	-1.1	0.5
Medication: Gliclazide	0.2	0.2	0.6	-0.2	0.0	0.8	-0.4	0.4
Illnesses of father: None of the above (group 1)	0.4	0.5	2.0	0.2	0.1	1.4	0.4	-0.6
Smoking status: Current	1.8	2.8	5.0	0.4	-2.2	-1.7	1.7	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.5	5.4	-1.8	-2.2	-2.3	1.3	-1.5
Whole body water mass	0.3	1.7	4.3	1.7	-0.3	-0.7	0.9	-2.1
Leg predicted mass (right)	0.4	2.4	6.1	1.8	-0.2	-1.1	1.1	-2.5
Arm fat mass (left)	0.3	1.2	2.9	0.8	1.7	-1.2	-1.0	-0.4
Number of self-reported non-cancer illnesses	1.9	3.3	7.2	-1.1	2.7	0.4	-2.1	1.9
Average weekly champagne plus white wine intake	1.0	1.4	4.8	2.2	0.9	0.3	-0.8	0.8
Miserableness	0.1	0.2	0.7	-0.3	0.8	-0.4	-0.4	-0.1
Guilty feelings	0.3	0.5	1.7	-0.5	-0.6	-1.3	0.2	-0.3
Wears glasses or contact lenses	4.2	4.9	10.0	0.9	1.8	2.1	-3.2	2.5
Ever taken oral contraceptive pill	0.4	0.4	1.5	0.3	-1.2	-0.0	0.1	-0.6
Hearing aid user	0.4	0.4	1.4	-1.2	0.3	-0.2	0.5	-0.5
Mother’s age at death	2.0	2.5	3.4	-1.6	1.2	1.8	-1.5	1.8
Financial situation satisfaction	0.8	0.9	2.3	0.4	-0.2	-0.8	1.5	-1.3
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.9	0.7	-0.5	0.3	0.2	-1.4
Commuting to job workplace: Public transport	2.5	3.0	5.3	1.4	-1.7	-1.3	2.3	-1.7
Eye problems/disorders: Glaucoma	0.1	0.1	0.1	0.4	-0.1	-0.2	-0.2	-0.3
Medication: Blood pressure	1.0	2.0	4.0	-0.4	1.4	-1.8	-2.0	0.7
Pain type(s) experienced in last month: Hip pain	2.6	3.2	5.2	-1.5	1.1	2.2	-2.3	1.7
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.8	-0.3	-0.1	0.5	0.5	-0.9
High cholesterol (Self-reported)	0.3	0.5	1.1	0.7	0.8	-0.4	-1.1	-0.1
Medication: Bendroflumethiazide	0.2	0.4	0.8	-0.1	0.8	-0.9	-0.6	-0.1
Medication: Paracetamol	0.5	0.8	1.7	1.1	0.7	0.4	-0.5	1.3
Medication: Lisinopril	0.4	0.5	1.0	0.5	1.0	0.2	-1.0	0.4
Medication: Atorvastatin	1.1	1.3	3.3	-0.8	-0.1	-0.8	1.4	-1.8
Illnesses of father: High blood pressure	0.4	0.5	1.5	0.1	1.2	-0.2	-0.9	0.4
Alcohol drinker status: Never	1.1	1.4	4.2	-1.1	0.8	0.8	-2.0	0.5
Ever smoked	0.8	1.4	2.7	1.6	-1.1	-0.2	1.6	-0.4
Basal metabolic rate	0.3	1.4	3.6	1.5	0.1	-0.8	0.7	-1.9
Leg fat percentage (left)	1.4	5.0	10.4	0.6	3.2	0.3	-3.1	2.1
Arm fat-free mass (left)	0.2	0.9	3.3	1.8	0.7	0.1	-0.1	-0.7
Number of operations (self-reported)	2.3	3.3	6.0	-0.6	2.5	1.2	-2.0	2.3
Average weekly beer plus cider intake	1.1	1.6	3.2	-0.7	-1.2	1.5	1.8	-0.8
Irritability	0.3	0.5	1.9	-0.5	1.4	-0.3	-0.1	-0.3
Risk taking	0.1	0.2	0.3	-0.5	-0.3	-0.5	-0.4	-0.4
Ever had prostate specific antigen (PSA) test	1.0	1.2	3.2	1.8	1.3	-0.5	-0.3	0.9
Fractured/broken bones in last 5 years	0.3	0.4	0.8	-0.7	-0.9	-0.5	0.2	-0.5
Age started oral contraceptive pill	1.2	1.5	4.5	-1.3	2.1	0.8	-0.5	-0.8
Diastolic blood pressure, automated reading	0.5	1.5	3.0	-1.6	1.7	-0.9	-1.1	0.2
Ever depressed for a whole week	1.3	1.6	4.6	2.2	-0.5	0.3	1.2	-1.4
Unable to work because of sickness or disability	1.7	2.2	4.3	1.0	1.4	1.7	-2.1	0.9
Commuting to job workplace: Cycle	1.5	1.8	6.1	-0.6	-2.5	-0.1	1.0	-1.2
Myopia	0.8	1.2	2.9	0.9	0.3	0.1	-1.5	1.7
Vascular/heart problems diagnosed by doctor	0.4	1.2	3.1	0.8	-0.6	1.2	1.8	-0.5
Cholesterol lowering medication	0.8	1.1	3.0	0.2	1.5	-0.7	-1.7	0.1
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	4.0	0.8	2.0	0.9	-0.4	0.7
Pain experienced in last month	1.3	2.2	5.3	2.3	-1.4	-1.6	0.9	-0.7
Supplements: Calcium	0.4	0.5	0.9	0.0	-0.1	0.9	-0.9	0.9
Basal cell carcinoma (self-reported)	1.1	1.3	2.7	0.6	1.6	1.1	-0.9	1.1
Heart attack/myocardial infarction (self-reported)	0.5	0.6	2.0	1.4	0.7	-0.7	-0.1	0.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.5	0.3	0.7	-0.4	0.2	-0.3
Heart disease (siblings)	0.6	0.7	1.6	-0.5	0.8	0.6	-1.0	1.2
Alcohol drinker status: Previous	1.1	1.2	2.1	-0.5	0.8	1.3	-1.2	1.4
Pack years of smoking	3.9	5.8	12.1	1.2	3.5	1.9	-2.1	2.7
Impedance of whole body	0.4	1.9	5.8	-0.8	-1.4	-0.4	2.4	-1.0
Leg fat mass (left)	0.6	2.2	5.7	1.0	2.4	-0.1	-2.0	0.7
Arm predicted mass (left)	0.2	0.9	2.8	1.7	0.7	-0.0	-0.1	-1.0