TWAS hub - AIG1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0817	0.0187	2.3e-12	0.029	0.045	0.058	0.062	0.067	5.2e-10	1.6e-14	3.3e-18	1.4e-19	3.8e-21
2	TCGA	Head and Neck Squamous Cell Carcinoma	0.0444	0.0220	9.3e-03	-0.002	0.010	0.008	NA	0.001	6.7e-01	2.6e-02	4.1e-02	NA	2.3e-01
3	TCGA	Lung Squamous Cell Carcinoma	0.0338	0.0152	4.1e-03	0.000	0.024	0.012	NA	0.011	2.8e-01	8.1e-04	1.2e-02	NA	1.8e-02
4	TCGA	Thyroid Carcinoma	0.0420	0.0210	5.6e-03	0.012	0.009	0.005	NA	0.004	2.1e-02	4.1e-02	9.9e-02	NA	1.2e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Gout (self-reported)	6.1	8.3	13.4	-2.0	-3.7	-3.1	-2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	5.1	5.9	9.0	-2.6	-3.0	-0.8	-2.7
Number of operations (self-reported)	4.7	7.0	9.2	2.6	2.2	2.7	3.0
Family relationship satisfaction	4.6	5.7	8.8	3.0	2.4	1.9	2.1
Had major operations	4.5	5.2	8.4	1.2	2.4	2.9	2.4
Impedance of leg (right)	4.4	21.4	27.6	-4.5	-4.9	-3.7	-5.3
Worry too long after embarrassment	4.4	7.3	12.1	-1.3	-3.2	-2.3	-3.5
Pulse wave reflection index	4.3	5.3	11.8	1.3	3.4	1.5	2.3
Type 2 Diabetes (T2D) (2018)	3.7	7.0	9.8	2.3	3.1	2.2	2.8
Tinnitus: Yes, but not now, but have in the past	3.5	3.7	5.9	-2.3	-1.5	-1.3	-2.4
Impedance of leg (left)	3.5	17.0	21.6	-3.8	-4.5	-3.4	-4.6
Bipolar Disorder (2011)	3.3	3.2	5.7	1.6	2.0	0.7	2.4
Diabetes (self-reported)	3.3	5.1	7.7	2.0	2.8	2.2	1.9
Average weekly spirits intake	3.1	3.8	7.3	1.8	1.5	1.5	2.7
Heart disease (mother)	3.1	3.8	6.7	-2.6	-1.5	-2.2	-1.2
Illnesses of father: None of the above (group 1)	3.0	3.7	6.4	-2.5	-1.1	-1.5	-2.2
Father’s age at death	2.9	3.9	9.8	3.1	1.3	1.3	1.7
Medication: Allopurinol	2.9	3.8	5.8	-0.7	-2.4	-2.4	-1.9
Eye problems/disorders: Glaucoma	2.9	3.5	8.9	-0.8	-1.9	-3.0	-0.7
Chronic bronchitis/emphysema (father)	2.8	3.3	4.0	1.9	1.9	1.5	2.0
Birth weight of first child	2.8	5.1	7.5	-1.3	-2.5	-2.2	-2.7
Average weekly red wine intake	2.5	3.6	7.4	2.7	1.0	1.7	1.8
Diabetes diagnosed by doctor	2.5	4.2	5.6	2.0	2.4	1.9	1.9
Friendships satisfaction	2.5	3.1	7.1	2.7	1.1	0.7	1.9
Breast cancer (self-reported)	2.5	3.0	5.7	1.7	1.0	1.6	2.4
Diastolic blood pressure, automated reading	2.5	7.6	12.2	-1.8	-3.0	-2.4	-3.5
Body Mass Index (BMI) (2010)	2.4	3.3	5.5	1.7	2.3	2.2	0.4
Mouth/teeth dental problems: Loose teeth	2.4	2.8	4.6	1.4	1.6	2.1	1.5
Mother’s age at death	2.4	2.9	5.3	1.6	1.5	2.3	1.3
Age at First Birth	2.3	3.4	5.2	1.5	1.7	1.7	2.3
Exposure to tobacco smoke outside home	2.3	3.1	6.3	1.0	2.5	1.9	1.2
Impedance of whole body	2.3	11.9	15.4	-2.9	-3.9	-3.2	-3.6
Financial situation satisfaction	2.2	2.8	6.5	1.3	1.5	2.6	0.8
Mean Putamen Volume	1.9	2.2	4.7	0.6	2.0	0.1	2.2
Depression (self-reported)	1.9	2.3	4.3	-0.8	-1.4	-2.1	-1.6
Lung cancer (father)	1.9	2.2	3.4	-1.2	-1.3	-1.5	-1.8
Birth weight	1.9	4.1	6.1	-1.4	-2.1	-1.9	-2.5
Frequency of depressed mood in last 2 weeks	1.8	2.6	4.9	2.2	1.4	1.5	1.1
Pulse wave peak to peak time	1.8	2.2	3.7	-1.3	-1.5	-1.1	-1.9
Mood swings	1.8	3.2	6.8	1.2	2.1	2.6	0.4
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	1.9	1.4	1.3	1.4	1.3
Happiness	1.7	2.1	2.7	1.7	1.6	1.5	0.9
Leg pain on walking	1.7	2.1	3.7	-1.9	-1.1	-1.2	-1.4
Medication: Co-codamol	1.6	1.9	2.5	1.5	1.4	0.7	1.6
Number of live births	1.6	2.3	5.2	-1.2	-1.3	-0.9	-2.3
Comparative body size at age 10	1.6	4.5	8.6	2.0	2.9	1.3	1.9
Schizophrenia (2018)	1.5	3.2	5.9	0.4	-1.7	-2.0	-2.4
Tense / ‘highly strung’	1.5	2.4	4.7	-0.4	-1.9	-1.1	-2.2
Medication: Ibuprofen	1.5	1.7	4.4	0.7	2.1	0.5	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.8	2.9	1.7	1.5	1.3	0.6
Myopia	1.5	2.1	4.0	1.1	1.7	2.0	-0.5
Had other major operations	1.4	1.7	3.1	1.7	0.1	1.5	1.2
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	4.6	-0.9	-1.5	-1.3	-2.2
Number of children fathered	1.4	1.6	2.7	-0.8	1.4	1.6	0.9
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	4.4	-2.1	-0.5	-1.4	0.6
Medication: Lisinopril	1.4	1.8	2.7	1.6	1.2	1.3	1.1
Schizophrenia vs Biploar Disorder	1.3	1.7	3.7	-0.7	-1.9	-0.9	-1.3
Worry (Nagel 2018)	1.3	2.7	4.4	-0.0	-2.1	-2.0	-1.5
Medication: Metformin	1.3	1.8	2.6	1.6	1.5	0.8	1.3
Neck or shoulder pain in last month	1.3	1.8	3.4	-0.0	-1.7	-1.1	-1.9
Primary Biliary Cirrhosis	1.2	1.7	3.5	-1.9	0.4	0.5	-1.7
Length of working week for main job	1.2	1.3	2.1	0.2	1.4	1.4	1.1
Mineral and other dietary supplements	1.2	1.6	3.3	-0.9	1.4	1.8	0.6
Medication: Gliclazide	1.2	1.4	2.8	1.7	1.0	1.2	0.8
Commuting to job workplace: Cycle	1.2	1.5	2.3	1.3	1.5	0.6	1.2
Depression (Nagel 2018)	1.1	1.7	5.8	2.4	0.7	0.4	0.5
Lupus	1.1	1.7	2.4	1.5	1.4	0.6	1.5
Blood White Count	1.1	7.8	16.9	2.1	2.2	2.2	4.1
Falls in the last year	1.1	1.5	2.9	-1.3	-0.4	-1.2	-1.7
Hair/balding pattern: Pattern 3	1.1	1.6	3.6	-0.4	-1.9	-0.9	-1.4
Pulse wave Arterial Stiffness index	1.1	1.3	2.1	1.2	1.1	0.6	1.4
Commuting to job workplace: Car/motor vehicle	1.1	1.3	2.9	1.7	0.8	0.9	1.0
Illnesses of siblings: Diabetes	1.1	1.3	3.1	-0.1	1.8	1.3	0.8
Commuting to job workplace: Walk	1.1	1.1	2.1	-1.1	-1.1	-0.3	-1.4
Relative age voice broke	1.0	1.5	2.4	1.1	1.6	1.2	1.1
Impedance of arm (right)	1.0	4.8	5.6	-1.8	-2.3	-2.2	-2.4
Time employed in main current job	1.0	1.2	3.9	-2.0	0.8	0.4	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.2	4.7	0.8	1.4	1.1	2.2
Supplements: Fish oil (including cod liver oil)	1.0	1.3	2.2	0.7	-1.5	-1.4	-0.6
High cholesterol (Self-reported)	1.0	1.8	2.6	-1.2	-1.5	-1.6	-1.1
Medication: Atorvastatin	1.0	1.2	2.4	1.2	-1.6	-0.9	-0.3
Lung FVC	0.9	4.7	11.8	1.9	1.8	0.7	3.4
Sitting height	0.9	6.2	10.2	-0.3	-2.2	-3.2	-3.2
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.4	-0.7	-1.3	0.1	-1.5
Impedance of arm (left)	0.9	4.3	6.2	-1.5	-2.5	-2.2	-2.0
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.4	-1.0	-0.9	0.2	-1.6
Ever had bowel cancer screening	0.9	1.1	2.8	1.7	0.9	0.3	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	2.5	-1.0	-0.4	-0.2	-1.6
Osteoporosis (self-reported)	0.9	1.1	2.2	0.4	-1.3	-1.5	-0.5
Guilty feelings	0.9	1.4	3.2	-0.9	-1.2	-0.4	-1.8
Schizophrenia (2014)	0.8	1.9	5.0	-0.0	-1.1	-1.1	-2.2
Triglycerides	0.8	1.4	2.5	0.3	1.6	1.3	1.1
Medication for hormone replacement therapy	0.8	0.9	1.3	0.7	1.2	1.1	0.9
Financial difficulties in last 2 years	0.8	1.0	2.8	0.0	0.6	1.0	-1.7
Blood clot in the leg (DVT)	0.8	1.0	2.3	-0.4	-1.5	-0.8	-0.9
Comparative height size at age 10	0.8	4.2	8.0	-0.9	-1.1	-2.8	-2.6
Long-standing illness, disability or infirmity	0.8	1.2	1.6	1.2	1.3	1.0	0.9
Illnesses of father: High blood pressure	0.8	1.0	3.2	1.8	0.3	0.3	0.7
Bipolar Disorder (2018)	0.7	1.1	2.3	0.9	1.5	-0.0	1.1
Crohns Disease (2012)	0.7	1.1	3.0	-0.6	-1.1	-0.0	-1.7
Fasting Glucose	0.7	0.8	2.0	0.5	1.4	0.9	0.3
Type 2 Diabetes (T2D) (2012)	0.7	0.9	2.0	0.5	1.4	0.8	0.7
Heel T-Score	0.7	5.3	14.4	-1.9	-1.5	-3.8	-1.0
BMI	0.7	4.2	9.8	1.2	3.1	1.4	1.9
Chronotype (morning person)	0.7	1.7	3.9	0.9	2.0	0.4	1.4
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.4	1.5	0.6	0.9	-0.1
Maternal smoking around birth	0.7	1.0	2.3	0.7	1.5	0.8	0.7
Age when periods started (menarche)	0.7	1.6	3.7	-0.0	1.9	1.6	0.2
Stomach or abdominal pain in last month	0.7	0.9	2.5	1.6	-0.2	1.0	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.5	0.5	1.6	0.5	0.8
Standing height	0.7	7.0	16.3	-1.0	-1.7	-2.8	-4.0
Peak expiratory flow (PEF)	0.7	1.7	3.6	1.0	1.9	1.3	0.8
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.9	-1.7	0.4	0.5	-1.2
Medication for pain relief, constipation, heartburn	0.7	1.3	2.2	-1.5	-1.2	-1.0	-0.6
Angina (self-reported)	0.7	0.9	1.5	0.5	1.2	0.6	1.2
Medication: Seretide 50 evohaler	0.7	0.8	2.0	-0.7	-1.4	-0.6	-0.6
Suffer from ‘nerves’	0.7	1.1	2.3	-0.1	-1.5	-1.0	-1.1
Knee pain experienced in last month	0.7	1.2	2.5	-0.1	-1.3	-1.6	-0.7
Leg fat-free mass (right)	0.7	3.7	6.8	2.6	2.3	0.9	1.3
Risk taking	0.7	1.1	2.7	0.4	0.8	1.6	0.9
Pain experienced in last month	0.7	1.2	3.7	0.1	0.5	0.9	1.9
Supplements: Calcium	0.7	0.8	1.5	-0.1	-1.2	-1.1	-0.6
Breast Cancer	0.6	1.5	3.1	-0.8	-1.1	-1.8	-1.1
LDL Cholesterol	0.6	0.9	1.7	-1.1	-0.8	0.3	-1.3
Angina	0.6	0.8	1.3	0.4	1.1	0.5	1.1
Diabetes (mother)	0.6	0.8	1.2	1.1	0.5	0.7	1.1
Townsend deprivation index at recruitment	0.6	0.9	2.3	-0.7	0.1	0.8	-1.5
Current tobacco smoking	0.6	0.9	2.5	0.9	0.6	1.6	0.1
Medication: Atenolol	0.6	0.8	1.3	1.1	0.7	0.7	0.9
Hearing difficulty/problems with background noise	0.6	0.9	1.6	0.2	-0.8	-1.3	-1.2
Worrier / anxious feelings	0.6	1.2	1.8	-0.2	-1.1	-1.4	-1.3
Noisy workplace	0.6	0.7	1.7	-0.5	1.3	0.6	0.7
Asthma	0.6	1.1	3.4	-1.8	-0.5	0.4	-0.8
Medication: Cholesterol lowering	0.6	0.9	2.0	1.2	0.2	-0.3	1.4
Prospective memory result	0.6	0.7	1.2	0.8	1.0	1.1	0.6
Hair/balding pattern: Pattern 4	0.6	1.5	3.2	-1.2	1.8	1.2	0.0
Loud music exposure frequency	0.6	0.6	1.1	-0.9	0.7	-1.0	-0.3
Glaucoma (self-reported)	0.6	0.8	2.8	0.4	-0.2	-1.7	-0.1
Number of full brothers	0.6	0.8	2.2	1.5	-0.5	-0.1	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	1.1	0.8	-1.1	-0.6	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	3.1	1.8	0.4	-0.4	0.7
Medication for cholesterol	0.6	0.9	2.4	0.3	-1.6	-1.0	-0.5
Smoking status: Current	0.6	0.9	1.9	1.1	0.5	1.4	0.4
Leg predicted mass (right)	0.6	3.5	6.5	2.6	2.2	0.9	1.2
Number of self-reported non-cancer illnesses	0.6	1.1	2.4	-0.6	-1.0	-0.8	-1.6
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.5	-0.0	-1.2	-0.9	-0.9
Medication: Bendroflumethiazide	0.6	0.9	1.8	-1.0	-1.3	-0.5	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	2.0	0.3	0.7	1.4	-0.3
Bipolar Disorder or Schizophrenia	0.5	1.2	2.3	0.9	-0.4	-1.5	-1.2
Depressed Affect (Nagel 2018)	0.5	1.0	1.7	1.2	1.3	1.0	-0.1
Alzheimer’s Disease (in mother)	0.5	0.6	1.0	0.1	-0.8	-1.0	-0.7
HbA1C	0.5	0.6	1.4	0.8	0.5	0.2	1.2
Systolic Blood Pressure	0.5	2.5	8.3	1.0	-0.3	0.8	2.9
Relative age of first facial hair	0.5	1.0	1.9	0.1	1.2	1.4	0.8
Vitamin and mineral supplements	0.5	0.7	1.0	-0.9	0.8	0.3	1.0
Pack years adult smoking proportion	0.5	0.7	1.6	-0.7	-0.5	0.7	-1.3
Leg fat-free mass (left)	0.5	2.5	4.6	2.1	2.0	0.7	0.8
Average weekly fortified wine intake	0.5	0.5	1.3	-0.8	-0.4	-1.1	0.2
Fed-up feelings	0.5	1.0	2.1	1.1	1.5	0.7	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.2	1.1	-0.7	-0.1	-1.0
Body mass index (BMI)	0.5	2.2	4.2	1.3	2.1	1.0	1.4
Pain all over the body in last month	0.5	0.5	1.4	-0.1	-0.2	0.8	-1.2
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	2.2	1.4	1.5	0.3	1.5
Pulse rate	0.5	0.9	2.4	1.5	-0.2	0.9	0.6
Qualifications: A levels/AS levels or equivalent	0.5	1.2	2.7	1.1	0.9	1.6	-0.4
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	3.4	-1.8	-0.7	-0.5	-0.0
Medication: Blood pressure	0.5	0.8	1.7	1.3	-0.7	-0.6	0.8
Migraine (self-reported)	0.5	0.6	1.3	1.1	1.1	-0.3	0.2
Pulse rate, automated reading	0.5	1.6	2.3	1.4	1.0	1.0	1.5
Number of full sisters	0.5	0.6	1.2	0.6	1.1	0.7	0.6
Chest pain or discomfort	0.5	0.7	1.5	-0.6	0.3	1.2	-1.0
Medication: Aspirin	0.5	0.7	1.0	1.0	-0.8	-0.9	0.4
Loneliness, isolation	0.5	0.8	1.6	1.3	0.5	0.9	-0.7
Back pain experienced in last month	0.5	0.7	1.7	0.8	1.3	-0.4	0.6
Average weekly champagne plus white wine intake	0.5	0.7	1.2	-0.5	1.1	0.8	0.8
Miserableness	0.5	0.8	1.7	0.2	1.1	1.3	-0.6
Ever taken oral contraceptive pill	0.5	0.5	1.9	0.0	0.5	1.4	-0.1
Commuting to job workplace: Public transport	0.5	0.6	1.2	0.1	-1.0	-1.1	-0.2
Average weekly beer plus cider intake	0.5	0.7	2.3	1.5	0.8	-0.2	0.3
Age started oral contraceptive pill	0.5	0.7	1.8	0.8	-0.3	-1.3	-0.5
Alzheimer’s Disease (including proxy)	0.4	0.6	1.5	0.6	-0.6	-1.2	-0.1
Crohns Disease (2017)	0.4	1.0	2.5	-0.7	-1.6	-0.3	-0.9
Major Depression (MDD)	0.4	0.5	1.4	1.2	0.2	-0.6	0.3
Ovarian Cancer	0.4	0.5	1.5	-0.4	-0.2	-0.6	1.2
Coronary Artery Disease (CAD)	0.4	0.5	1.2	-0.8	0.2	1.1	0.0
Neuroticism (2016)	0.4	0.6	1.2	-0.0	1.1	0.7	0.9
Height	0.4	6.9	23.4	-0.3	-1.2	-1.6	-4.8
Hypothyroidism (self reported)	0.4	0.9	2.6	-1.6	-1.0	-0.3	-0.1
Lung FEV1/FVC ratio	0.4	1.9	3.6	0.1	1.9	1.5	1.3
Neuroticism	0.4	0.9	2.8	1.7	-0.4	0.7	-0.1
Sensitivity / hurt feelings	0.4	0.7	1.6	-0.4	-0.3	1.1	-1.3
Ever had hysterectomy (womb removed)	0.4	0.4	1.3	0.5	-1.1	0.1	-0.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.0	0.1	0.2	1.0	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.7	-1.1	-0.4	-1.6	0.2
Qualifications: CSEs or equivalent	0.4	0.5	1.3	-0.0	-0.8	-1.1	-0.0
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.0	0.5	-1.0	-0.8	-0.3
Leg predicted mass (left)	0.4	2.3	4.2	2.0	2.0	0.7	0.8
Alcohol usually taken with meals	0.4	0.7	1.8	0.6	0.5	1.4	0.5
Medication: Simvastatin	0.4	0.6	1.7	-0.5	0.7	-0.1	1.3
Illnesses of mother	0.4	0.5	1.1	-0.4	0.7	1.0	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.8	0.6	-0.1	-0.5	-1.4
Emphysema/chronic bronchitis	0.4	0.5	1.0	0.0	-1.0	-0.8	-0.5
Medication: Omeprazole	0.4	0.5	1.3	-0.4	0.1	1.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.7	1.9	1.4	0.5	0.4	-0.8
Asthma (self-reported)	0.4	0.7	2.1	-1.5	-0.3	0.6	-0.5
Medication: Aspirin	0.4	0.5	0.9	0.9	-0.2	-0.7	0.8
Hearing aid user	0.4	0.5	1.2	0.6	0.4	0.5	1.1
Medication: Blood pressure	0.4	0.8	2.3	-0.8	1.5	0.6	-0.1
Ever depressed for a whole week	0.4	0.6	1.1	-0.4	-0.3	1.0	-0.9
Pack years of smoking	0.4	0.5	0.9	-0.5	-0.3	0.9	-1.0
Alzheimer’s Disease (in father)	0.3	0.4	0.6	0.4	0.4	-0.7	0.8
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.4	-1.5	-0.2	-0.3	-0.6
Respiratory disease	0.3	0.6	1.9	-1.4	0.2	0.4	-0.4
Tanning	0.3	3.1	6.5	0.3	1.8	1.6	2.5
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.9	0.3	0.8	0.1	0.9
Systolic blood pressure, automated reading	0.3	0.8	2.4	0.4	-0.8	-0.4	1.5
Diabetes (father)	0.3	0.4	0.6	0.8	0.5	0.6	0.7
Supplements: Glucosamine	0.3	0.4	1.2	1.1	0.5	0.2	0.3
Number of incorrect matches in round	0.3	0.5	1.1	-0.8	1.1	0.5	-0.4
Past tobacco smoking	0.3	0.6	1.9	-1.4	0.2	0.2	-0.6
Had menopause	0.3	0.4	1.0	1.0	-0.2	-0.4	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	2.2	-0.8	-0.5	-1.5	0.1
Qualifications: None of the above	0.3	0.6	1.0	0.3	-0.7	-0.8	1.0
Allergy	0.3	0.6	1.1	1.1	0.9	-0.4	0.5
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	0.8	-0.0	-0.9	-0.8	0.0
Alcohol intake versus 10 years previously	0.3	0.4	0.9	-0.5	0.5	0.5	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.0	0.4	-0.5	0.2	-1.0
Mouth/teeth dental problems: Dentures	0.3	0.6	1.5	-0.6	0.6	1.2	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	1.8	0.7	1.3	-0.4	1.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.1	0.1	0.2	0.8	-1.1
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.7	-0.1	0.8	-0.7	0.7
Medication: Amlodipine	0.3	0.4	1.0	0.1	-0.4	-0.8	1.0
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.7	0.8	-0.4	-0.6	0.2
Leg fat percentage (right)	0.3	1.0	1.8	-1.2	-0.3	-0.8	-1.3
Wheeze or whistling in the chest in last year	0.3	0.5	1.1	-0.2	0.9	1.1	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.9	-0.9	-0.1	-0.0	-0.7
Health satisfaction	0.3	0.4	1.0	0.2	-0.2	0.7	-1.0
Shortness of breath walking on level ground	0.3	0.4	0.6	-0.6	-0.5	0.5	-0.8
Eye problems/disorders: None of the above	0.3	0.4	0.8	-0.9	0.1	0.5	-0.7
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.5	0.7	-0.4	-0.1	-0.7
Unable to work because of sickness or disability	0.3	0.4	1.2	1.1	0.5	0.2	0.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.2	-0.1	-1.1	-0.2	-0.6
Alcohol drinker status: Previous	0.3	0.3	0.7	0.2	0.9	0.6	-0.1
Neuroticism (Nagel 2018)	0.2	0.5	1.2	0.5	-0.6	-0.2	-1.1
Irritable Bowel Disease (IBD)	0.2	0.4	0.8	-0.2	-0.9	-0.3	-0.8
Reaction Time	0.2	0.4	1.1	0.7	0.2	-0.1	1.1
Rheumatoid Arthritis	0.2	0.3	0.8	-0.2	-0.2	-0.6	-0.9
Ulcerative Colitis	0.2	0.2	0.8	0.3	-0.2	0.1	-0.9
Smoking Status	0.2	0.6	1.6	1.3	-0.5	0.6	0.4
Number of treatments/medications taken	0.2	0.3	0.5	0.6	0.7	0.3	0.4
Hearing difficulty/problems: Yes	0.2	0.2	0.6	0.8	0.5	-0.1	0.4
Trunk fat percentage	0.2	1.0	2.6	-0.1	-0.4	-1.6	-1.1
Hand grip strength (right)	0.2	0.5	0.9	0.8	0.3	1.0	0.5
Multivitamins +/- minerals	0.2	0.3	0.6	0.1	-0.5	-0.7	-0.8
Medication: Levothyroxine sodium	0.2	0.3	0.6	-0.8	-0.3	0.3	0.6
Trunk fat mass	0.2	0.9	2.3	0.0	-0.0	-1.5	-1.2
Waist circumference	0.2	0.6	2.1	0.5	1.4	0.3	-0.2
Nervous feelings	0.2	0.3	1.2	0.1	-1.1	0.1	-0.1
Forced vital capacity (FVC)	0.2	0.8	2.0	1.4	0.8	-0.2	0.6
Mouth/teeth dental problems	0.2	0.3	0.9	-0.2	-0.9	-0.0	-0.3
Fluid intelligence score	0.2	0.4	0.8	-0.9	-0.4	-0.8	-0.1
Neuroticism score	0.2	0.5	0.8	0.9	-0.3	0.6	-0.8
Exposure to tobacco smoke at home	0.2	0.2	0.6	-0.3	0.8	0.4	0.3
Medication: Paracetamol	0.2	0.4	0.8	0.4	0.7	0.1	-0.9
Headache pain in last month	0.2	0.3	0.9	0.1	0.4	0.4	-0.9
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.3	0.1	-0.5	0.6	-0.5
High blood pressure (siblings)	0.2	0.3	0.7	0.0	0.8	0.6	-0.1
Forced vital capacity (FVC), Best measure	0.2	0.6	1.0	0.9	0.5	-1.0	0.5
Body fat percentage	0.2	0.7	1.5	-0.3	-0.2	-1.2	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.4	0.6	0.5	0.1	-0.6
Age at first live birth	0.2	0.3	0.8	0.2	0.9	-0.2	0.5
Whole body fat mass	0.2	0.6	1.4	0.0	0.1	-1.2	-1.1
Arm predicted mass (right)	0.2	0.8	1.7	1.1	1.3	0.2	-0.2
Alcohol intake frequency.	0.2	0.4	1.2	0.2	-0.3	0.4	-1.1
Illnesses of father: Heart disease	0.2	0.2	0.7	0.4	0.3	0.8	0.0
Smoking status: Previous	0.2	0.3	1.0	1.0	-0.4	0.0	0.2
Whole body fat-free mass	0.2	1.3	2.5	1.6	1.6	0.4	0.2
Eye problems/disorders: Cataract	0.2	0.2	0.5	-0.3	0.3	0.7	-0.2
Osteoarthritis (self-reported)	0.2	0.3	0.6	0.3	-0.4	-0.8	-0.5
Whole body water mass	0.2	1.3	2.5	1.6	1.6	0.4	0.1
Wears glasses or contact lenses	0.2	0.3	0.5	-0.6	0.2	-0.4	-0.7
Medication: Paracetamol	0.2	0.2	0.4	0.6	0.7	-0.2	-0.3
Ever smoked	0.2	0.4	1.2	1.1	0.2	-0.1	0.7
Basal metabolic rate	0.2	1.0	2.0	1.4	1.4	0.2	-0.0
Leg fat percentage (left)	0.2	0.6	1.0	-0.9	-0.0	-0.6	-1.0
Fractured/broken bones in last 5 years	0.2	0.3	0.5	-0.5	-0.0	-0.6	0.7
Cholesterol lowering medication	0.2	0.3	1.4	-1.2	0.0	0.0	0.0
Heart disease (siblings)	0.2	0.2	0.6	-0.8	-0.2	-0.2	-0.5
Ulcerative Colitis (UC)	0.1	0.2	0.3	0.2	-0.5	-0.6	-0.2
HDL Cholesterol	0.1	0.2	0.5	-0.7	-0.6	-0.1	-0.4
Blood Red Count	0.1	1.0	2.5	-0.0	0.2	1.3	1.6
Allergy or Eczema	0.1	0.3	0.5	-0.2	0.0	0.7	0.7
Cardiovascular Disease	0.1	0.2	0.3	-0.6	-0.5	-0.1	-0.5
Hair Pigment	0.1	2.2	4.4	1.4	1.6	2.1	0.3
Supplements: Zinc	0.1	0.1	0.3	-0.2	-0.6	-0.2	-0.1
Severe depression (siblings)	0.1	0.2	0.4	0.6	-0.0	-0.2	-0.5
Taking other prescription medications	0.1	0.1	0.2	0.3	0.2	0.3	-0.5
High blood pressure (mother)	0.1	0.1	0.2	0.4	-0.3	-0.1	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.3	0.4	-0.5	-0.2	-0.5
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	0.5	-0.2	-0.2	-0.0
Heart attack	0.1	0.1	0.3	-0.4	-0.5	-0.0	-0.1
Medication: Ramipril	0.1	0.1	0.4	0.1	-0.3	0.1	0.6
Illnesses of siblings	0.1	0.1	0.2	-0.1	-0.4	-0.5	-0.2
Weight	0.1	0.5	1.4	0.7	1.2	-0.2	-0.5
Arm fat percentage (right)	0.1	0.3	0.4	0.6	0.7	-0.6	0.1
Trunk fat-free mass	0.1	0.7	1.3	1.0	1.1	0.1	-0.5
Hip circumference	0.1	0.4	0.7	0.0	0.7	-0.5	-0.8
Medication: Lansoprazole	0.1	0.1	0.3	0.3	0.3	0.6	0.1
Arm fat mass (right)	0.1	0.5	1.1	0.8	1.1	-0.4	0.0
Trunk predicted mass	0.1	0.7	1.3	1.0	1.1	0.1	-0.6
Breastfed as a baby	0.1	0.2	0.6	-0.8	0.0	-0.1	-0.2
Arm fat-free mass (right)	0.1	0.5	0.9	0.9	0.9	-0.1	-0.5
Mean time to correctly identify matches	0.1	0.2	0.5	0.3	0.4	-0.2	0.7
Leg fat mass (right)	0.1	0.3	0.4	0.2	0.6	-0.5	-0.6
Overall health rating	0.1	0.3	0.5	0.7	-0.1	0.6	-0.5
Age at last live birth	0.1	0.2	0.6	-0.1	0.8	-0.1	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	0.6	0.3	0.1	0.1
Supplements: Vitamin C	0.1	0.1	0.3	0.3	-0.3	0.3	-0.6
Hypertension (Self-reported)	0.1	0.2	0.3	0.6	0.2	0.5	-0.2
Arm fat percentage (left)	0.1	0.3	0.4	0.6	0.6	-0.6	0.2
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.4	0.1	0.1	-0.3	0.6
Qualifications: nursing, teaching	0.1	0.1	0.2	0.4	0.2	0.2	-0.2
Arm fat mass (left)	0.1	0.5	0.9	0.9	0.9	-0.5	-0.0
Alcohol drinker status: Never	0.1	0.1	0.2	-0.4	-0.2	0.1	-0.2
Arm fat-free mass (left)	0.1	0.4	0.6	0.8	0.8	-0.2	-0.7
Irritability	0.1	0.2	0.5	0.4	-0.3	0.7	0.1
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	0.4	0.0	-0.4	0.2
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.5	-0.4	-0.7	0.0	-0.3
Leg fat mass (left)	0.1	0.2	0.6	0.2	0.8	-0.4	-0.4
Arm predicted mass (left)	0.1	0.5	1.2	0.8	1.1	0.1	-0.4
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.3	-0.5	-0.1	0.1	-0.3
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood Eosinophil Count	0.0	0.4	0.7	-0.1	0.5	0.8	-0.7
Blood Platelet Count	0.0	0.5	1.7	-0.4	-0.0	0.3	1.3
Waist Hip Ratio (WHR)	0.0	0.1	0.1	-0.3	0.2	-0.2	-0.2
Hand grip strength (left)	0.0	0.1	0.2	-0.0	0.3	0.4	0.2
Serious illness, injury or assault to yourself	0.0	0.0	0.1	-0.0	0.0	0.2	-0.3
High blood pressure	0.0	0.1	0.3	0.1	0.0	-0.1	-0.6
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.2	0.1	-0.2	0.4	0.4
Qualifications: College or University degree	0.0	0.1	0.2	0.4	-0.2	-0.4	-0.0
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.1	-0.3	-0.0	0.2	0.2
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.2	-0.0	0.3	0.3	0.4

Hub : Genes

AIG1

Models

Trait associations