Hub : Genes

AKIRIN2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.0737	0.0365	6.7e-03	0.092	NA	0.055	NA	0.084	2.4e-09	NA	4.1e-06	NA	1.2e-08
2	GTEx	Nerve Tibial	0.0841	0.0418	3.1e-03	0.001	NA	0.005	NA	0.011	2.4e-01	NA	1.3e-01	NA	5.0e-02
3	METSIM	Adipose	0.0389	0.0160	6.3e-04	0.026	0.016	0.007	0.015	0.019	7.2e-05	1.7e-03	3.0e-02	2.3e-03	6.3e-04
4	NTR	Blood	0.0415	0.0116	3.3e-11	0.049	0.039	0.049	0.044	0.049	1.6e-15	1.4e-12	1.8e-15	3.4e-14	1.2e-15
5	YFS	Blood	0.1322	0.0232	0.0e+00	0.146	0.129	0.146	0.146	0.143	3.0e-45	6.2e-40	2.1e-45	2.2e-45	2.2e-44
6	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1570	0.0710	7.2e-04	0.046	0.064	0.051	NA	0.032	1.2e-03	1.6e-04	6.4e-04	NA	6.3e-03
7	TCGA	Thyroid Carcinoma	0.0590	0.0350	2.0e-03	-0.003	0.012	-0.001	NA	-0.002	9.1e-01	2.4e-02	3.9e-01	NA	7.2e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.4	0.6	1.7	-0.5	-0.6	-0.9	-1.3	-0.3	0.0	-0.8
Bipolar Disorder or Schizophrenia	0.3	0.6	2.2	-0.0	-0.5	-1.5	-0.5	-0.1	-1.1	-0.5
Depressed Affect (Nagel 2018)	1.0	2.1	5.9	-2.4	-2.0	-0.3	0.6	1.3	0.6	-1.4
Depression (Nagel 2018)	3.0	4.5	10.6	-2.9	-2.2	-1.3	-2.4	3.3	-0.4	-0.0
Intelligence (Savage-Jansen 2018)	0.6	1.8	8.5	1.0	1.0	0.9	0.7	-2.9	0.9	-0.1
Neuroticism (Nagel 2018)	0.2	0.4	0.8	-0.9	-0.7	-0.1	0.9	0.2	0.2	-0.7
Schizophrenia (2018)	0.3	0.6	2.1	0.4	-0.2	-1.2	0.9	0.1	-1.4	0.0
Schizophrenia vs Biploar Disorder	0.1	0.2	0.4	-0.4	-0.2	0.2	-0.1	0.2	0.7	0.6
Worry (Nagel 2018)	0.7	1.5	3.3	-1.7	-1.8	-0.5	1.6	0.3	0.1	-1.2
Alzheimer’s Disease (in mother)	0.4	0.5	1.5	-0.6	-0.9	0.1	1.2	-0.1	0.0	-0.6
Alzheimer’s Disease (in father)	1.4	1.5	3.4	-1.8	-1.6	0.2	0.3	-0.6	0.9	-1.8
Alzheimer’s Disease (including proxy)	1.0	1.4	4.5	-0.9	-1.5	-0.5	1.2	-0.6	-0.6	-2.1
Crohns Disease (2017)	2.2	4.9	14.6	-1.0	-1.7	-3.0	0.1	1.7	-2.0	-3.8
Irritable Bowel Disease (IBD)	1.8	4.3	10.4	-1.4	-1.7	-2.7	-1.4	1.6	-1.6	-3.2
Ulcerative Colitis (UC)	0.6	1.2	3.7	-0.7	-0.7	-1.2	-1.9	0.8	-0.5	-1.1
Major Depression (MDD)	0.7	0.8	3.0	-1.3	-0.8	-0.1	-0.2	1.7	-0.5	0.3
Reaction Time	1.7	3.2	7.8	-2.8	-2.7	-0.8	-1.0	1.6	1.4	-1.2
Verbal and Numeric Reasoning (VNR)	0.5	1.1	3.7	0.3	0.5	0.9	0.4	-1.9	1.5	0.6
Breast Cancer	0.6	1.5	4.4	-0.2	-0.2	2.0	2.1	-0.5	1.1	-0.4
Ovarian Cancer	0.1	0.2	0.4	-0.6	-0.5	0.1	0.1	0.4	-0.1	0.5
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.4	2.1	8.1	1.6	1.0	-0.3	1.6	-2.9	-0.6	-0.2
Bipolar Disorder (2011)	3.5	3.3	6.3	-1.0	-1.9	-2.5	-0.6	1.8	-2.0	-2.2
Body Mass Index (BMI) (2010)	0.6	0.9	3.2	-0.3	0.6	0.6	-1.8	-0.5	0.8	1.0
Coronary Artery Disease (CAD)	1.3	1.5	3.6	0.0	-0.5	-1.3	1.5	0.1	-1.7	-1.9
Crohns Disease (2012)	1.8	2.9	11.7	-0.7	-1.5	-1.4	1.6	0.9	-0.8	-3.4
Mean Putamen Volume	2.0	2.2	3.7	1.9	1.7	1.2	1.9	-0.6	0.1	1.9
Fasting Glucose	1.0	1.2	3.8	-1.1	-1.2	-0.9	-0.9	-0.3	0.2	-1.9
HbA1C	0.5	0.6	1.4	1.2	0.9	-0.6	-0.3	-0.7	-0.9	-0.4
HDL Cholesterol	0.8	1.4	3.9	2.0	1.5	0.2	1.4	-1.0	-0.6	0.1
LDL Cholesterol	0.3	0.5	1.0	0.7	1.0	0.7	-0.1	-0.8	-0.1	0.6
Lupus	0.5	0.8	2.0	-0.3	0.1	-1.2	-1.2	0.8	-1.4	-0.4
Neuroticism (2016)	0.6	0.9	2.4	-1.5	-1.0	1.1	0.3	0.9	0.8	0.7
Primary Biliary Cirrhosis	0.4	0.5	1.8	0.6	1.1	-0.3	-1.3	-0.2	-0.2	-0.6
Rheumatoid Arthritis	1.0	1.3	2.7	-1.5	-1.2	-0.8	-1.7	0.3	0.8	-1.1
Schizophrenia (2014)	0.4	0.8	1.6	1.1	0.4	-0.8	1.3	-1.0	-1.0	-0.1
Triglycerides	1.0	1.7	4.2	-0.5	-0.8	-1.4	0.2	1.6	-2.0	-1.5
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.6	-0.4	-0.5	-0.5	0.1	0.8	0.3	-0.7
Ulcerative Colitis	0.5	0.7	3.1	-0.4	-0.6	-0.7	-0.6	-0.5	0.3	-1.8
Blood Eosinophil Count	0.9	7.1	13.3	-0.1	-2.6	-3.3	3.7	1.4	-2.9	-2.9
Blood Platelet Count	0.1	1.0	5.6	0.2	-0.4	0.8	2.4	0.9	-0.0	0.1
Blood Red Count	0.1	0.6	2.2	0.8	-0.1	-0.0	1.5	0.3	-0.7	-1.1
Blood White Count	1.0	7.3	19.0	-0.5	2.4	2.9	-4.4	0.2	3.0	2.9
Heel T-Score	0.4	3.5	8.9	-0.1	-1.0	-3.0	0.7	-0.1	-2.3	-3.0
BMI	0.3	1.6	3.9	-0.1	0.7	1.5	-1.8	0.9	1.0	2.0
Height	0.1	1.3	3.4	0.0	0.7	1.9	0.8	-1.4	1.1	1.0
Waist Hip Ratio (WHR)	1.1	5.1	10.4	-0.7	-1.8	-3.0	0.1	2.2	-3.2	-2.8
Systolic Blood Pressure	0.2	0.8	1.8	-1.0	-1.3	-0.0	1.1	0.1	0.0	-1.4
Smoking Status	2.2	5.3	15.2	-1.7	-2.2	-2.1	0.4	3.9	-2.2	-2.2
Allergy or Eczema	1.6	4.1	11.8	3.4	1.8	-0.0	2.6	-1.9	-1.8	0.4
Cardiovascular Disease	0.1	0.2	0.6	-0.2	-0.1	0.3	0.1	-0.6	0.7	-0.8
Hypothyroidism (self reported)	2.2	5.0	12.7	-2.3	-3.6	-2.2	1.2	2.0	-0.8	-2.4
Respiratory disease	1.8	4.0	6.6	-0.8	-1.7	-2.0	1.9	2.3	-2.3	-2.6
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.3	0.8	1.0	-0.1	-1.1	-1.0	0.4	1.1
Lung FEV1/FVC ratio	0.3	1.4	3.0	0.8	1.1	1.7	-0.1	-1.6	1.4	0.8
Lung FVC	0.7	3.7	8.9	1.5	3.0	2.1	-1.7	-1.8	1.7	1.0
Neuroticism	0.4	1.0	3.2	-1.8	-1.1	0.1	0.7	0.7	0.5	-1.2
Chronotype (morning person)	1.3	3.0	6.7	2.6	2.6	1.9	0.4	-0.6	0.1	1.8
Hair Pigment	0.0	1.0	2.0	1.2	0.9	-0.7	-1.4	0.7	-0.9	0.6
Tanning	0.0	0.3	0.7	0.8	0.8	0.6	0.2	0.6	0.2	-0.0
Hand grip strength (left)	0.2	0.5	1.8	-0.7	0.0	0.9	-1.3	0.4	0.4	-0.1
Number of treatments/medications taken	0.8	1.4	2.0	-1.4	-1.4	-1.0	-1.1	1.3	1.1	-1.0
Average weekly spirits intake	0.2	0.2	0.8	0.5	0.2	-0.2	0.9	0.1	0.4	-0.1
Sensitivity / hurt feelings	0.6	1.1	2.0	1.2	1.4	-0.2	0.1	1.3	-1.1	0.9
Frequency of depressed mood in last 2 weeks	1.6	2.2	6.3	-2.2	-1.7	-0.8	-0.6	2.5	-0.3	-0.8
Hearing difficulty/problems: Yes	0.6	0.9	2.0	-1.2	-1.1	-0.5	-0.6	1.4	-0.7	-0.5
Relative age of first facial hair	0.5	1.0	2.6	1.2	0.3	-0.7	1.1	0.4	-1.6	1.2
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	3.2	-0.8	-0.1	0.9	-0.5	0.6	1.0	1.8
Ever used hormone-replacement therapy (HRT)	1.2	1.5	3.7	-1.9	-1.5	0.3	0.3	1.2	1.7	-0.4
Ever had hysterectomy (womb removed)	0.9	1.0	2.4	1.1	1.5	-0.3	-1.2	0.5	-0.5	1.1
Systolic blood pressure, automated reading	0.3	1.0	2.6	-1.5	-1.5	-0.0	-0.3	1.6	0.1	0.1
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	1.4	0.2	0.8	0.2	-1.2	0.1	0.7	0.1
Angina	1.0	1.3	6.3	-0.7	-0.5	-0.9	-0.7	0.1	-1.0	-2.5
Medication for hormone replacement therapy	1.3	1.5	3.6	-0.4	-0.3	0.8	1.0	-1.5	1.9	-1.6
Vitamin and mineral supplements	1.0	1.4	4.0	-0.2	-0.9	-2.0	-0.5	1.2	-1.6	-0.7
Supplements: Zinc	3.1	3.3	8.4	-1.2	-1.4	-2.2	-0.6	1.3	-2.2	-2.9
Medication: Co-codamol	0.3	0.3	1.0	0.5	0.6	-0.3	-1.0	0.3	-0.2	0.6
Medication: Metformin	0.2	0.3	1.0	0.2	0.1	-1.0	-0.7	0.2	-0.8	0.2
Diabetes (father)	0.8	1.0	3.2	0.6	0.1	-1.4	0.6	0.3	-1.8	-0.8
Diabetes (mother)	1.5	1.9	5.1	-1.1	-1.4	-1.6	-1.1	2.3	-0.6	-1.1
Severe depression (siblings)	0.8	0.9	1.7	0.9	1.0	1.3	1.0	-1.2	0.3	-0.1
Pack years adult smoking proportion	0.6	0.9	2.3	0.8	0.8	0.8	0.1	1.5	-0.4	1.5
Impedance of leg (right)	3.1	15.0	27.9	-0.8	-3.5	-5.2	3.1	2.0	-4.9	-5.3
Leg fat-free mass (left)	1.4	7.5	15.7	0.4	2.4	4.0	-1.9	-1.7	3.6	3.5
Trunk fat percentage	0.5	2.1	4.7	-0.7	-1.4	-1.9	-0.5	2.2	-1.9	0.1
Hand grip strength (right)	0.2	0.5	1.2	0.6	1.1	0.8	-0.9	-0.2	-0.4	0.5
Townsend deprivation index at recruitment	1.4	2.0	6.4	0.6	-0.0	-1.4	-1.0	1.6	-2.5	-1.3
Current tobacco smoking	1.2	2.0	7.8	0.1	-0.3	-1.2	0.1	2.8	-2.0	-0.7
Average weekly fortified wine intake	0.5	0.6	1.4	-0.9	0.1	1.2	-1.1	-0.5	1.0	0.1
Maternal smoking around birth	1.5	2.1	3.9	-1.3	-1.4	-1.7	-0.7	1.4	-1.4	-2.0
Fed-up feelings	0.7	1.3	2.8	-1.7	-1.2	-1.1	-0.3	0.9	-0.3	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.7	8.7	-1.8	-1.8	-1.4	-0.9	2.9	-0.8	-0.6
Relative age voice broke	2.6	4.0	11.1	-0.1	-1.4	-3.2	0.7	1.9	-3.3	0.1
Taking other prescription medications	2.1	3.3	7.6	-1.6	-2.1	-2.2	-1.1	2.8	-1.1	-1.1
Age when periods started (menarche)	0.2	0.5	2.1	0.7	-0.1	-0.3	1.4	-0.6	-0.0	-0.5
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.7	0.6	0.8	-0.5	-0.3	-0.7	-0.1	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	3.9	-1.7	-2.0	-1.6	0.0	1.3	-0.8	0.2
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	3.9	-1.9	-2.0	-0.4	0.4	1.7	-0.2	-1.6
Qualifications: CSEs or equivalent	1.2	1.6	2.6	-0.8	-1.3	-1.4	1.6	0.7	-1.2	-1.6
Serious illness, injury or assault to yourself	1.7	2.0	4.0	-1.7	-1.2	-1.5	-2.0	1.8	-0.4	0.8
High blood pressure	0.3	0.7	2.2	-1.1	-0.6	-0.2	-1.5	0.6	0.6	-0.7
Hayfever, allergic rhinitis or eczema	0.9	2.0	5.8	2.4	1.1	-0.3	2.0	-0.8	-1.3	-0.5
Multivitamins +/- minerals	0.4	0.5	1.3	-0.1	0.5	1.1	-0.1	-1.2	0.9	0.1
Stomach or abdominal pain in last month	1.0	1.2	3.0	-1.7	-1.7	-0.1	0.7	-0.4	0.9	-1.1
Supplements: Glucosamine	1.1	1.5	3.7	1.4	1.8	-0.1	-1.0	-1.9	0.5	-0.0
Diverticular disease/diverticulitis (self-reported)	2.8	3.3	8.6	2.4	2.5	0.2	-1.1	-0.8	-1.0	2.9
Medication: Atenolol	0.1	0.2	0.4	-0.3	-0.1	0.4	-0.4	0.5	0.7	-0.2
Medication: Levothyroxine sodium	1.6	2.7	7.0	-2.4	-2.6	-0.7	0.5	1.6	0.8	-1.6
Sitting height	0.8	5.6	13.5	0.1	1.7	3.7	-0.0	-2.3	3.5	2.3
Chronic bronchitis/emphysema (father)	1.7	2.0	4.2	-0.0	-0.8	-1.8	0.9	2.1	-2.1	-1.0
High blood pressure (mother)	0.7	1.0	2.6	0.2	0.7	0.7	-0.3	-1.6	0.9	-1.5
Body mass index (BMI)	0.3	1.1	3.4	-0.3	0.2	0.5	-1.9	1.1	0.3	1.7
Impedance of leg (left)	2.9	13.9	26.7	-0.9	-3.5	-5.2	2.8	2.5	-5.0	-4.4
Leg predicted mass (left)	1.4	7.6	16.1	0.4	2.3	4.0	-1.8	-1.7	3.6	3.5
Trunk fat mass	0.2	0.8	2.4	-0.6	-0.8	-0.6	-0.7	1.6	-0.6	0.8
Waist circumference	0.3	1.0	3.4	-0.8	-0.5	-0.3	-1.8	1.3	-0.3	0.9
Number of incorrect matches in round	0.3	0.6	1.6	-0.9	-0.5	0.7	-0.0	-0.4	1.3	0.9
Past tobacco smoking	1.9	3.5	7.7	2.4	2.8	0.7	-0.6	-1.6	-0.5	2.8
Alcohol usually taken with meals	0.6	1.0	2.5	1.3	1.4	0.3	0.9	-1.6	-0.2	0.3
Nervous feelings	0.7	1.2	3.1	-1.5	-1.8	-0.6	1.1	-0.2	0.1	-1.3
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.9	-1.4	-0.7	0.7	0.6	0.2	0.9	-1.2
Hearing difficulty/problems with background noise	0.7	1.1	3.5	-1.2	-1.4	0.3	1.9	0.1	0.2	-1.1
Hair/balding pattern: Pattern 2	1.1	1.4	3.5	-1.9	-1.2	0.2	-0.9	-0.7	1.8	-0.8
Had menopause	2.1	2.6	6.9	-2.6	-1.9	1.0	-0.6	0.6	2.3	1.0
Had other major operations	0.1	0.2	0.4	-0.3	-0.4	-0.7	-0.4	0.5	-0.2	-0.4
Forced vital capacity (FVC)	0.7	2.8	8.1	1.4	2.1	1.8	0.2	-2.9	1.4	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	3.5	-1.4	-1.7	-1.9	-0.5	1.3	-1.0	-0.4
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	3.1	-1.8	-1.5	-0.1	0.3	1.4	0.1	-0.5
Qualifications: None of the above	4.7	10.0	21.4	-4.0	-4.1	-3.0	-1.9	4.6	-0.4	-1.8
Financial difficulties in last 2 years	2.0	2.7	6.6	-1.1	-1.4	-2.1	-1.7	2.6	-1.2	-0.4
Mouth/teeth dental problems	1.5	2.3	5.5	1.4	1.4	1.6	1.3	-2.3	1.3	1.0
Heart attack	0.2	0.2	0.7	0.2	0.7	0.8	-0.2	0.2	0.4	0.3
Allergy	1.1	2.4	5.5	-0.7	0.6	1.4	-2.3	-1.3	2.1	1.7
Pain all over the body in last month	1.2	1.3	3.0	0.0	-0.7	-1.6	-0.9	1.7	-1.5	-0.3
Diabetes (self-reported)	0.6	1.0	2.6	0.4	0.8	-0.1	-1.6	-0.8	0.9	1.4
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	2.8	0.1	-0.3	-0.6	1.7	-0.5	-0.1	-0.8
Medication: Ramipril	0.4	0.5	1.3	0.0	0.5	0.5	-0.9	-1.0	1.2	0.4
Medication: Simvastatin	0.6	0.8	1.6	1.0	1.2	-0.1	-1.3	-1.1	0.2	0.5
Fluid intelligence score	0.8	1.7	5.4	0.1	-0.1	0.7	2.0	-2.3	1.0	-0.8
Illnesses of siblings	1.7	2.3	7.0	0.6	0.6	1.5	0.8	-2.4	2.6	0.3
Neuroticism score	0.4	0.8	2.5	-0.8	-0.5	-0.9	0.0	0.9	-0.8	-1.6
Weight	0.4	1.9	4.9	-0.4	0.6	1.7	-1.4	0.2	1.6	2.2
Impedance of arm (right)	1.4	6.6	12.9	0.1	-2.0	-3.6	2.7	0.7	-3.4	-3.1
Arm fat percentage (right)	0.4	1.7	4.4	0.2	-0.4	-1.7	-0.9	2.1	-1.7	0.9
Trunk fat-free mass	1.3	7.7	18.1	0.5	2.3	4.2	-1.1	-1.5	4.0	3.3
Hip circumference	0.2	0.9	2.6	-0.4	0.3	0.6	-1.6	0.1	0.6	1.6
Time employed in main current job	1.1	1.2	3.0	1.4	1.2	0.0	1.7	-0.8	-1.3	0.1
Alcohol intake versus 10 years previously	0.6	0.9	2.4	-0.2	-0.9	-1.0	0.7	1.6	-1.3	-0.5
Father’s age at death	1.0	1.4	3.5	-0.0	0.9	1.4	-1.5	-0.2	1.9	1.0
Worrier / anxious feelings	0.1	0.3	1.0	-1.0	-0.7	-0.3	0.4	0.2	0.0	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.6	-0.9	-1.3	-0.7	1.2	0.8	-0.7	-0.6
Falls in the last year	1.3	1.8	10.0	-0.9	-0.2	-1.2	-3.2	-0.1	0.6	-0.1
Hair/balding pattern: Pattern 3	0.1	0.2	0.6	0.3	0.0	-0.4	0.1	-0.4	-0.4	0.8
Number of live births	0.9	1.3	2.2	-1.4	-1.5	-1.5	-1.0	0.9	0.5	-0.7
Forced expiratory volume in 1-second (FEV1)	1.0	3.4	8.0	1.8	2.4	2.0	0.1	-2.8	1.3	0.8
Pulse rate	0.3	0.6	2.3	-0.1	0.1	-0.2	-1.5	0.7	-0.0	1.1
Happiness	0.8	1.0	2.5	0.2	0.2	1.6	1.6	-1.0	0.9	0.3
Noisy workplace	1.9	2.3	6.1	-2.0	-2.5	-0.5	0.4	1.1	1.3	-1.7
Qualifications: A levels/AS levels or equivalent	2.2	4.8	10.7	3.0	3.3	1.1	-1.2	-2.4	-1.0	2.0
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.7	7.1	-0.5	-1.1	-2.7	-0.6	1.1	-2.4	-1.8
Mouth/teeth dental problems: Dentures	3.4	5.7	11.9	-3.2	-3.4	-1.5	0.2	3.1	-0.6	-2.3
Asthma	1.9	3.8	5.9	-0.9	-1.9	-1.4	2.4	2.4	-1.7	-2.4
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.5	-0.1	0.1	-0.7	-0.6	0.2	0.3	-0.4
Medication: Cholesterol lowering	0.5	0.8	1.9	0.8	0.9	-0.6	-0.4	-1.4	-0.6	-1.0
Depression (self-reported)	0.5	0.6	1.2	-1.0	-0.8	-0.6	-1.1	0.5	0.1	-0.8
Medication: Lansoprazole	1.2	1.4	2.6	-1.4	-1.1	-0.2	-1.6	1.6	1.1	0.6
Prospective memory result	0.9	1.1	4.4	-1.2	-1.2	-0.6	-0.2	-0.3	0.1	-2.1
Lung cancer (father)	0.4	0.4	1.3	-0.7	-0.8	-0.1	-0.5	1.1	0.3	0.5
Illnesses of mother	1.1	1.4	2.6	1.3	1.3	1.4	1.0	-0.7	0.5	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.1	8.5	1.9	2.9	1.9	-1.2	-2.9	1.6	1.1
Pulse wave Arterial Stiffness index	0.4	0.5	1.6	-0.1	-0.2	0.9	-0.8	0.4	0.4	1.3
Impedance of arm (left)	1.2	5.5	10.2	-0.0	-1.8	-3.2	2.4	0.5	-3.1	-3.1
Arm fat mass (right)	0.2	1.0	2.7	-0.1	0.1	-0.2	-1.4	1.5	-0.2	1.6
Trunk predicted mass	1.3	7.6	17.6	0.4	2.2	4.2	-1.2	-1.5	4.0	3.3
Standing height	0.3	3.0	8.8	-0.3	0.7	2.6	0.5	-2.0	3.0	1.1
Length of working week for main job	0.4	0.4	1.1	0.5	0.3	0.2	1.0	-1.0	-0.0	-0.6
Exposure to tobacco smoke at home	1.3	1.4	3.7	-0.5	-0.9	-1.6	-0.5	1.3	-1.9	-0.7
Breastfed as a baby	0.2	0.3	1.2	-0.1	0.3	0.1	-0.7	0.6	-0.1	-1.1
Tense / ‘highly strung’	1.3	2.2	6.8	0.5	-0.3	-1.6	1.4	0.2	-1.9	-2.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	3.7	-0.8	-0.7	0.2	0.7	0.5	0.0	-1.9
Hair/balding pattern: Pattern 4	0.1	0.3	1.0	0.6	0.4	-0.3	0.1	1.0	-0.6	-0.6
Birth weight of first child	1.3	2.3	4.8	0.3	0.8	2.0	1.5	-2.2	1.8	1.0
Peak expiratory flow (PEF)	0.3	0.8	1.8	0.7	0.9	1.3	-0.1	-0.9	1.0	0.7
Pulse wave reflection index	0.6	0.8	2.0	0.9	1.3	1.4	-0.4	-0.6	0.1	0.7
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.1	-0.1	-0.1	0.5	1.1	-0.5	-0.3	-0.9
Loud music exposure frequency	0.8	0.8	2.2	0.3	0.2	-1.3	-1.0	0.6	-1.5	0.4
Qualifications: O levels/GCSEs or equivalent	1.7	2.8	6.5	2.1	2.3	1.1	0.1	-2.5	0.3	1.2
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.2	0.9	0.8	-0.5	-0.1	0.1	-1.1	0.7
Blood clot in the leg (DVT)	1.0	1.4	3.0	-0.9	-1.3	-1.3	0.5	1.7	-0.7	-1.2
Medication: Paracetamol	0.3	0.5	1.8	0.5	0.5	-0.2	-1.4	0.3	0.3	0.8
Headache pain in last month	0.2	0.3	1.5	0.2	-0.4	-0.6	1.2	-0.0	-0.4	-0.2
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	3.8	-1.4	-1.6	-0.7	0.1	2.0	-0.3	0.3
Glaucoma (self-reported)	0.3	0.4	1.1	-0.3	-0.4	1.1	0.5	0.3	1.0	0.4
Gout (self-reported)	1.9	2.6	8.0	-2.2	-1.8	1.3	0.4	0.6	2.8	-0.1
Hypothyroidism/myxoedema (self-reported)	3.4	6.6	17.0	-3.5	-4.1	-2.1	0.7	2.6	-0.1	-2.4
Medication: Amlodipine	0.2	0.3	0.9	0.2	0.5	0.2	0.3	0.8	-0.2	1.0
Medication: Ventolin 100micrograms inhaler	1.5	1.9	4.5	-0.7	-1.2	-1.0	0.7	2.1	-0.8	-2.1
Birth weight	3.0	6.6	14.6	1.1	2.6	3.2	-1.4	-3.8	2.8	1.9
Chronic bronchitis/emphysema (mother)	1.5	1.8	3.7	0.8	1.0	-1.2	-1.9	1.5	-1.3	1.4
High blood pressure (siblings)	0.3	0.4	0.8	0.3	0.9	0.9	-0.6	0.4	-0.3	0.5
Forced vital capacity (FVC), Best measure	0.8	2.9	7.5	1.3	2.4	1.6	-0.8	-2.7	1.6	0.3
Body fat percentage	0.7	2.7	5.8	-0.8	-1.4	-2.2	-0.9	2.4	-2.1	-0.0
Leg fat percentage (right)	1.3	4.6	10.4	-1.0	-1.8	-2.8	-1.2	3.2	-2.8	-0.7
Arm fat-free mass (right)	1.1	5.4	12.5	-0.4	1.3	3.4	-1.5	-0.5	3.5	3.0
Exposure to tobacco smoke outside home	0.9	1.2	2.8	0.7	0.9	1.7	1.0	-0.6	0.9	1.5
Comparative body size at age 10	0.4	1.2	3.3	0.6	1.1	1.8	-0.8	-0.4	1.3	1.1
Number of full brothers	0.8	1.0	3.7	0.6	-0.2	-0.1	1.9	1.0	-0.6	-1.1
Worry too long after embarrassment	0.4	0.6	2.0	0.3	0.6	-1.2	-0.3	0.3	-1.4	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.5	0.5	0.5	0.3	0.9	-1.1	0.2	-1.2
Wheeze or whistling in the chest in last year	1.3	2.3	9.6	-0.0	-0.6	2.0	3.1	1.0	1.1	-0.2
Number of children fathered	0.3	0.3	0.9	-0.8	-0.4	-0.2	-0.6	0.0	0.4	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.5	0.8	0.4	1.6	1.5	-1.1	0.8	0.4
Age at first live birth	1.2	2.1	10.4	0.8	1.5	0.9	-0.4	-3.2	0.8	0.1
Pulse wave peak to peak time	0.3	0.3	0.8	0.1	0.3	-0.6	0.8	-0.5	-0.2	-0.9
Health satisfaction	1.4	1.8	5.2	-0.8	-1.9	-0.7	2.3	1.1	-0.1	-1.4
Shortness of breath walking on level ground	0.8	0.9	2.3	-1.5	-1.0	0.3	-0.9	0.7	1.4	0.2
Qualifications: College or University degree	4.3	13.5	23.6	3.1	4.3	4.5	-0.3	-4.9	2.7	4.0
Eye problems/disorders: None of the above	0.3	0.3	1.5	0.4	0.2	0.6	1.2	0.5	0.1	0.1
Mouth/teeth dental problems: Loose teeth	0.4	0.4	1.6	0.4	-0.0	-0.2	0.7	1.2	-0.8	-0.3
Emphysema/chronic bronchitis	0.4	0.5	1.4	-1.2	-0.5	-0.2	-0.8	0.6	0.7	-0.5
Medication for pain relief, constipation, heartburn	0.3	0.5	2.4	0.1	-0.3	0.5	1.6	-0.3	-0.5	-0.2
Neck or shoulder pain in last month	1.6	2.3	6.3	0.1	-0.9	-1.2	1.8	1.4	-1.6	-2.5
Medication: Blood pressure	0.7	1.2	3.0	0.6	1.2	1.7	-0.5	-1.0	1.6	0.2
Angina (self-reported)	1.2	1.6	6.4	-0.8	-0.6	-1.2	-0.9	0.1	-1.2	-2.5
Migraine (self-reported)	0.4	0.5	2.2	-0.6	-1.0	0.3	1.5	-0.1	0.3	-0.2
Medication: Ibuprofen	0.5	0.6	1.3	0.2	0.4	-1.2	-0.9	0.5	-0.3	-1.1
Medication: Allopurinol	0.2	0.3	1.1	-0.3	0.1	0.4	-0.5	-0.2	1.1	0.8
Medication: Omeprazole	1.5	1.8	5.6	-1.5	-1.3	-1.0	-1.2	2.4	-0.3	-0.6
Medication: Seretide 50 evohaler	1.4	1.6	3.9	-0.4	-1.3	-0.9	1.6	2.0	-0.7	-1.3
Mean time to correctly identify matches	1.7	3.3	8.5	-2.9	-2.6	0.0	-0.8	1.1	2.4	-0.6
Heart disease (mother)	1.2	1.5	2.5	-1.0	-0.9	-1.6	-1.2	1.6	-1.1	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.2	0.5	-0.4	-0.8	0.7	0.0	-1.1	-0.5
Whole body fat mass	0.2	0.9	2.3	-0.7	-0.6	-0.4	-1.3	1.5	-0.3	1.0
Leg fat mass (right)	0.3	1.2	3.7	-0.9	-0.8	-0.7	-1.4	1.9	-0.7	0.6
Arm predicted mass (right)	1.0	5.3	12.6	-0.0	1.7	3.5	-1.3	-0.8	3.3	2.9
Pulse rate, automated reading	0.7	2.3	6.3	-0.2	-0.3	-2.1	-1.6	1.5	-2.5	-0.6
Alcohol intake frequency.	2.2	5.2	15.3	0.3	-0.8	-3.5	1.0	2.5	-3.9	-0.9
Comparative height size at age 10	0.5	2.6	8.5	-2.2	-0.8	1.9	0.1	0.6	2.9	0.5
Number of full sisters	1.3	1.6	5.4	-0.6	-0.5	-1.5	-2.3	1.6	-0.2	-0.1
Suffer from ‘nerves’	0.6	1.0	2.6	-1.4	-1.1	0.0	-0.0	-0.4	1.0	-1.6
Overall health rating	1.5	3.2	9.2	-2.0	-2.4	-1.4	-0.1	3.0	-0.7	-0.6
Chest pain or discomfort	0.7	1.0	3.0	0.1	-0.1	1.0	1.3	-0.7	0.7	-1.7
Had major operations	0.6	0.7	2.6	0.5	0.5	-0.7	-0.3	1.1	-1.6	0.3
Age at last live birth	0.7	1.0	5.3	-0.3	0.4	0.8	-0.2	-2.3	0.8	-0.3
Family relationship satisfaction	1.1	1.3	3.6	1.2	0.9	1.2	1.9	-1.2	0.6	0.5
Leg pain on walking	0.6	0.7	2.0	0.6	0.5	1.4	1.0	-1.0	0.5	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.1	0.1	-0.6	-0.9	0.6	1.5	-1.1	-1.1
Commuting to job workplace: Car/motor vehicle	1.1	1.2	3.6	0.6	-0.1	-0.8	1.1	1.5	-1.9	-0.4
Illness, injury, bereavement, stress in last 2 years	3.0	3.6	7.8	1.5	2.0	2.8	0.7	-2.8	1.6	0.6
Medication: Aspirin	0.9	1.2	7.3	-0.2	0.4	-0.4	-2.7	0.3	-0.0	0.8
Supplements: Vitamin C	0.4	0.4	1.4	-0.5	0.2	1.2	0.1	-0.4	1.0	-0.4
Knee pain experienced in last month	0.5	0.8	2.0	-1.4	-0.8	0.2	-1.1	0.7	1.0	0.1
Hypertension (Self-reported)	0.3	0.7	2.2	-1.1	-0.5	0.0	-1.5	0.2	1.1	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.6	3.1	6.6	-2.6	-2.3	-1.2	-1.4	2.3	0.2	-0.9
Illnesses of father: Heart disease	0.1	0.2	0.8	0.4	0.3	-0.3	-0.2	-0.9	-0.2	-0.1
Illnesses of siblings: Diabetes	0.7	0.9	2.7	0.5	-0.0	-1.1	0.2	1.3	-1.7	0.3
Smoking status: Previous	1.4	2.1	5.2	-2.1	-2.3	-0.6	-0.1	0.9	0.7	-1.9
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	3.0	0.7	1.0	0.8	0.0	-1.7	1.0	1.0
Whole body fat-free mass	1.4	8.2	18.3	0.3	2.3	4.3	-1.5	-1.5	4.0	3.6
Leg fat-free mass (right)	1.7	9.2	18.1	0.5	2.6	4.2	-2.1	-1.7	3.8	4.3
Arm fat percentage (left)	0.4	1.6	3.9	0.0	-0.4	-1.5	-1.2	2.0	-1.6	0.9
Average weekly red wine intake	0.3	0.5	1.2	0.9	1.0	0.5	-0.0	-1.1	-0.2	0.1
Handedness (chirality/laterality): Left-handed	0.4	0.5	2.2	0.2	-0.1	0.9	1.5	0.4	0.8	0.2
Mood swings	0.2	0.4	1.7	0.3	0.7	1.3	0.2	0.1	0.6	0.2
Loneliness, isolation	0.6	0.8	1.6	-1.3	-1.1	-1.0	-0.6	0.5	-0.7	-0.9
Long-standing illness, disability or infirmity	0.7	1.1	3.4	-1.2	-1.4	-0.8	-0.2	1.9	-0.2	-0.5
Ever had bowel cancer screening	1.1	1.3	4.0	0.1	0.6	2.0	0.0	-1.0	1.7	0.9
Diabetes diagnosed by doctor	0.3	0.5	1.2	0.4	0.4	-1.1	-1.1	-1.0	0.0	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	3.4	-1.8	-1.2	-0.4	-1.5	1.2	-0.0	-1.5
Friendships satisfaction	0.4	0.5	1.1	-0.8	-0.9	0.0	1.0	0.1	0.4	-0.6
Qualifications: nursing, teaching	1.8	2.9	6.0	2.4	2.0	1.5	0.5	-2.4	-0.3	1.4
Commuting to job workplace: Walk	0.4	0.4	1.1	-0.2	-0.3	-0.8	-1.1	0.5	-0.8	-0.3
Eye problems/disorders: Cataract	1.1	1.3	3.0	1.7	1.6	-0.1	-0.6	-1.6	-0.7	0.4
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	8.0	-0.4	0.4	-1.0	-2.8	0.0	-0.2	-0.6
Medication for cholesterol	0.3	0.4	1.5	0.5	0.2	0.2	1.2	-0.4	-1.0	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	9.0	-1.0	-1.0	-1.7	-0.8	-0.5	-0.1	-3.0
Back pain experienced in last month	0.6	0.8	2.2	-0.7	-1.0	-0.6	-0.1	1.5	-0.9	-1.0
Mineral and other dietary supplements	1.4	1.9	4.2	-1.1	-2.0	-1.7	0.5	1.5	-1.6	-0.0
Breast cancer (self-reported)	1.0	1.2	2.6	0.8	0.6	-1.3	-1.0	0.5	-1.6	1.3
Asthma (self-reported)	2.0	4.0	7.2	-0.8	-1.9	-1.3	2.7	2.5	-1.8	-2.3
Osteoporosis (self-reported)	0.6	0.7	1.6	-1.3	-1.2	-0.3	-0.9	0.6	0.1	-1.0
Osteoarthritis (self-reported)	0.1	0.1	0.5	-0.0	-0.5	-0.3	0.1	0.7	-0.2	-0.2
Medication: Aspirin	1.0	1.3	7.8	-0.0	0.8	0.2	-2.8	-0.1	0.4	0.6
Medication: Gliclazide	0.5	0.5	1.3	0.7	0.7	0.2	-0.3	-1.1	0.8	-0.9
Illnesses of father: None of the above (group 1)	0.9	1.1	2.6	-1.0	-0.9	-1.2	-1.3	1.6	-0.1	0.4
Smoking status: Current	1.1	1.8	7.3	0.2	-0.3	-0.9	0.5	2.7	-1.8	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	6.0	-0.5	0.2	1.9	-0.1	-1.1	2.5	-0.3
Whole body water mass	1.4	7.9	17.2	0.3	2.2	4.2	-1.5	-1.5	4.0	3.6
Leg predicted mass (right)	1.7	9.0	17.8	0.5	2.6	4.2	-2.1	-1.6	3.7	4.2
Arm fat mass (left)	0.2	1.0	2.5	-0.2	0.1	-0.1	-1.5	1.4	-0.1	1.6
Number of self-reported non-cancer illnesses	2.9	5.0	10.5	-2.4	-2.9	-2.1	0.3	2.4	-0.7	-3.2
Average weekly champagne plus white wine intake	1.2	1.7	4.2	2.0	2.0	0.0	-0.1	-1.7	-0.2	0.9
Miserableness	0.5	0.9	2.5	-1.6	-1.1	0.2	-0.0	1.1	0.9	-0.6
Guilty feelings	0.7	1.1	3.5	-0.2	1.1	1.9	-1.0	0.0	0.7	1.3
Wears glasses or contact lenses	1.7	2.0	6.2	0.5	1.0	1.8	-0.3	-0.6	1.6	2.5
Ever taken oral contraceptive pill	3.3	3.7	8.0	1.8	2.8	2.1	-1.5	-2.1	1.7	0.7
Hearing aid user	0.5	0.5	1.4	-0.8	-0.5	1.2	-0.6	0.1	0.9	0.1
Mother’s age at death	0.8	1.0	2.2	-1.5	-0.6	0.4	-1.4	0.6	1.2	0.6
Financial situation satisfaction	0.2	0.2	0.8	0.4	0.4	0.9	0.6	0.4	0.3	0.1
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.2	0.6	0.2	-0.2	1.1	0.6	-0.3	-0.3
Commuting to job workplace: Public transport	2.0	2.3	8.9	1.5	1.9	0.7	-1.0	-3.0	0.6	-0.2
Eye problems/disorders: Glaucoma	0.8	0.9	2.4	-1.4	-1.5	-0.4	-0.3	1.4	0.3	0.1
Medication: Blood pressure	0.9	1.7	5.3	-1.1	-0.8	-1.3	-2.3	1.8	-0.2	-0.2
Pain type(s) experienced in last month: Hip pain	2.6	3.3	6.7	-1.2	-1.6	-2.6	-1.3	1.9	-1.7	-2.0
Supplements: Fish oil (including cod liver oil)	3.3	4.2	12.2	0.9	2.0	3.5	0.4	-1.7	3.0	0.6
High cholesterol (Self-reported)	0.1	0.2	0.8	0.1	-0.2	-0.9	-0.0	0.3	-0.6	-0.1
Medication: Bendroflumethiazide	0.2	0.3	0.7	0.5	0.8	0.6	-0.5	0.0	0.8	-0.3
Medication: Paracetamol	0.3	0.4	1.4	0.7	0.7	-0.4	-1.2	-0.2	-0.1	0.4
Medication: Lisinopril	0.7	0.9	1.6	-1.3	-1.2	-1.0	-1.1	0.7	0.3	0.3
Medication: Atorvastatin	0.1	0.1	0.5	-0.0	0.3	0.7	0.3	-0.1	0.1	0.3
Illnesses of father: High blood pressure	0.3	0.3	0.6	0.6	0.8	0.4	-0.4	-0.8	-0.8	-0.2
Alcohol drinker status: Never	0.3	0.4	1.5	0.0	-0.0	-0.4	0.2	1.2	-0.1	0.9
Ever smoked	1.9	3.4	7.0	-2.3	-2.6	-0.2	1.5	1.4	0.7	-2.6
Basal metabolic rate	1.2	6.4	13.4	0.3	2.0	3.7	-1.6	-1.1	3.4	3.4
Leg fat percentage (left)	1.2	4.5	12.0	-1.1	-1.8	-2.6	-1.3	3.5	-2.5	-0.1
Arm fat-free mass (left)	0.9	4.8	11.1	-0.5	1.1	3.0	-1.6	-0.3	3.3	3.0
Number of operations (self-reported)	0.9	1.3	4.3	1.0	0.5	-1.4	-0.3	1.3	-2.1	0.0
Average weekly beer plus cider intake	0.4	0.6	1.9	0.1	-0.0	0.8	-0.4	-0.4	1.2	-1.4
Irritability	1.2	2.1	5.8	2.3	2.4	0.5	-0.1	-1.8	-0.1	0.3
Risk taking	0.6	0.9	1.9	-0.2	0.6	1.0	-1.4	-1.1	1.1	-0.6
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	0.5	0.1	-0.3	-0.3	0.7	0.1	0.7
Fractured/broken bones in last 5 years	0.3	0.3	1.2	-0.0	-1.1	-0.4	0.4	0.2	0.1	-0.8
Age started oral contraceptive pill	1.0	1.3	2.8	1.2	1.6	0.9	0.1	-0.8	0.7	1.7
Diastolic blood pressure, automated reading	0.7	2.2	7.6	-0.4	0.5	0.5	-2.8	1.5	-0.1	2.2
Ever depressed for a whole week	0.7	0.9	2.8	-1.4	-1.1	0.1	-0.6	1.7	0.1	0.3
Unable to work because of sickness or disability	0.5	0.6	2.1	-0.4	-0.5	-0.5	0.1	0.9	-1.5	-0.7
Commuting to job workplace: Cycle	1.9	2.3	7.3	0.3	0.7	2.2	0.9	-2.7	1.6	-0.6
Myopia	0.5	0.8	1.7	1.3	1.3	1.1	0.7	-0.4	-0.1	0.2
Vascular/heart problems diagnosed by doctor	0.2	0.6	2.8	0.6	-0.1	0.1	1.7	0.2	-0.5	1.0
Cholesterol lowering medication	0.3	0.5	2.2	0.3	0.2	0.5	-0.2	0.3	0.8	1.5
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	3.0	-1.1	-1.0	-0.9	-1.3	1.7	0.1	-0.7
Pain experienced in last month	1.2	2.0	4.0	1.2	2.0	1.5	-0.6	-1.5	1.3	1.5
Supplements: Calcium	0.9	0.9	2.2	1.5	1.3	-0.5	-0.4	0.4	-1.4	0.3
Basal cell carcinoma (self-reported)	0.4	0.4	1.4	-0.4	-0.3	0.5	0.2	1.2	0.8	-0.7
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.9	0.3	0.8	0.9	-0.0	0.1	0.2	0.3
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.6	-0.7	-1.0	-1.2	0.2	1.6	-0.8	-0.9
Heart disease (siblings)	2.1	2.6	8.0	-0.2	-0.7	-2.1	0.0	0.7	-2.8	-2.2
Alcohol drinker status: Previous	2.1	2.4	5.9	-0.9	-1.2	-2.4	-0.6	1.5	-2.1	-1.2
Pack years of smoking	0.5	0.8	2.2	0.5	0.6	1.0	0.0	1.5	0.2	1.3
Impedance of whole body	2.0	10.2	20.5	-0.6	-2.9	-4.5	2.6	1.5	-4.2	-4.0
Leg fat mass (left)	0.3	1.3	3.9	-0.8	-0.8	-0.7	-1.3	2.0	-0.7	0.9
Arm predicted mass (left)	0.8	4.3	9.9	-0.5	1.1	2.9	-1.4	-0.2	3.1	2.9