TWAS hub - AKNA

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.3010	0.1060	5.5e-03	0.240	NA	0.106	NA	0.137	7.7e-07	NA	1.1e-03	NA	2.3e-04
2	GTEx	Cells Transformed fibroblasts	0.2940	0.0650	3.9e-06	0.171	NA	0.086	NA	0.167	7.5e-13	NA	5.6e-07	NA	1.5e-12
3	GTEx	Colon Sigmoid	0.3460	0.1090	2.7e-03	0.046	NA	0.048	NA	0.056	9.5e-03	NA	8.4e-03	NA	5.0e-03
4	GTEx	Esophagus Muscularis	0.2580	0.0560	5.9e-07	0.071	NA	0.132	NA	0.129	4.3e-05	NA	2.1e-08	NA	3.0e-08
5	GTEx	Lung	0.1284	0.0485	4.1e-03	0.034	NA	0.015	NA	0.008	1.1e-03	NA	2.5e-02	NA	7.6e-02
6	METSIM	Adipose	0.0693	0.0241	3.0e-04	0.028	0.025	0.037	0.027	0.036	3.7e-05	8.7e-05	3.0e-06	6.2e-05	3.1e-06
7	YFS	Blood	0.0817	0.0161	1.2e-13	0.026	0.048	0.051	0.061	0.045	4.2e-09	1.7e-15	2.0e-16	2.8e-19	1.1e-14

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Ever taken oral contraceptive pill	6.2	6.9	12.9	3.2	2.6	2.8	3.6	2.4	2.3	0.2
HDL Cholesterol	4.2	7.1	12.6	-2.8	-3.5	-3.2	-2.6	-2.2	-2.6	-0.2
Number of full brothers	3.5	4.4	8.2	-2.9	-1.4	-0.7	-2.4	-2.6	-2.3	-1.5
Diabetes diagnosed by doctor	3.3	5.4	8.1	2.1	2.5	2.3	2.4	2.7	2.9	0.9
Medication: Metformin	3.2	4.6	8.6	2.1	1.9	1.5	1.7	2.9	2.9	1.3
Hearing difficulty/problems: Yes	3.0	4.6	14.4	-1.1	-3.8	-2.9	-1.9	-1.7	-0.8	0.8
Average weekly beer plus cider intake	3.0	4.3	11.5	2.9	1.9	1.8	0.8	3.4	1.6	0.6
Diastolic blood pressure, automated reading	2.9	9.1	18.0	-3.0	-3.8	-4.2	-3.0	-3.5	-0.5	0.8
Ever had prostate specific antigen (PSA) test	2.8	3.3	10.9	0.9	1.9	3.3	2.4	0.9	0.9	-0.1
Mean Putamen Volume	2.6	3.0	5.0	-1.8	-1.3	-2.2	-2.1	-2.1	-1.4	0.3
Impedance of arm (right)	2.6	12.0	34.0	-3.3	-5.8	-3.8	-2.6	-2.5	-3.1	-1.4
Medication for hormone replacement therapy	2.5	2.7	5.4	-2.3	-1.2	-1.5	-2.2	-1.9	-1.3	-0.0
Mouth/teeth dental problems: Dentures	2.5	4.2	7.1	2.3	2.6	2.7	1.8	2.2	1.1	-1.0
Emphysema/chronic bronchitis	2.5	2.8	9.7	0.7	3.1	1.2	0.8	1.8	0.8	1.8
Type 2 Diabetes (T2D) (2018)	2.4	4.5	9.4	2.1	3.1	1.4	2.1	2.3	2.3	0.9
Impedance of whole body	2.4	12.2	32.2	-3.2	-5.7	-4.5	-2.6	-2.9	-2.7	-1.0
Hearing aid user	2.3	2.5	5.8	-1.0	-1.7	-1.0	-2.4	-1.3	-1.9	-1.4
Impedance of arm (left)	2.2	10.2	28.7	-2.7	-5.4	-3.8	-2.5	-2.2	-2.9	-1.3
Impedance of leg (left)	2.1	10.4	23.8	-3.3	-4.9	-4.2	-2.2	-3.1	-2.3	-0.8
Supplements: Glucosamine	1.9	2.5	5.6	2.4	-0.6	0.1	0.8	2.2	2.3	1.0
Diabetes (self-reported)	1.9	3.0	4.5	1.4	1.9	1.4	1.9	2.1	2.0	1.1
Suffer from ‘nerves’	1.9	3.0	8.4	1.5	1.0	1.3	2.9	1.9	1.7	1.0
Medication: Ventolin 100micrograms inhaler	1.8	2.3	7.5	-0.4	-0.6	-2.7	-0.8	0.1	0.1	2.7
Medication for pain relief, constipation, heartburn	1.8	3.1	8.6	-2.2	-0.3	-0.8	-0.8	-2.9	-2.0	-1.6
Impedance of leg (right)	1.7	8.3	21.1	-2.9	-4.6	-3.5	-2.2	-2.6	-1.9	-1.0
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	6.0	-1.9	-0.9	-0.9	-0.8	-2.4	-1.5	-0.7
Neck or shoulder pain in last month	1.7	2.4	4.6	1.8	0.4	-0.1	0.3	2.0	2.1	2.1
Medication: Ibuprofen	1.7	2.0	6.7	1.6	0.4	0.8	0.9	2.6	1.5	0.9
Medication: Lansoprazole	1.6	1.8	5.0	2.2	0.7	0.8	-0.1	2.2	1.4	0.3
High blood pressure (siblings)	1.6	2.2	4.8	-1.6	-1.8	-1.4	-2.2	-1.4	-1.2	-0.2
Ever depressed for a whole week	1.6	1.9	6.9	0.1	1.8	1.7	2.6	-0.5	0.4	-0.3
Worry (Nagel 2018)	1.5	3.2	7.9	1.9	0.5	1.3	2.8	1.6	2.4	0.7
Supplements: Zinc	1.5	1.6	4.3	1.2	1.1	-0.2	1.7	0.4	2.1	1.1
Financial difficulties in last 2 years	1.5	2.0	3.7	1.5	1.0	1.8	1.9	1.4	1.3	0.2
Mineral and other dietary supplements	1.5	2.0	4.4	-2.0	0.7	1.6	0.2	-1.0	-2.1	-1.2
Alcohol drinker status: Never	1.5	1.8	4.3	-1.4	-1.0	-0.9	-2.1	-1.1	-1.7	0.6
Diabetes (father)	1.4	1.7	3.7	1.1	1.2	0.6	1.6	0.8	1.9	1.3
Medication: Simvastatin	1.4	2.1	6.8	1.7	0.0	-1.2	0.4	0.6	2.6	1.7
Lung cancer (father)	1.4	1.6	7.1	-0.9	0.4	2.7	-0.0	0.3	-1.4	-1.1
Pain type(s) experienced in last month: Hip pain	1.4	1.8	3.5	-0.3	-1.4	-0.0	-1.0	-1.6	-1.9	-1.8
Commuting to job workplace: Cycle	1.4	1.7	3.4	-0.7	-1.3	-1.4	-1.4	-1.5	-1.8	-0.4
Nervous feelings	1.3	2.4	5.3	1.9	1.2	1.2	2.3	1.3	1.8	0.7
Angina (self-reported)	1.3	1.8	4.7	1.1	2.2	0.5	0.8	1.3	1.7	0.9
Lupus	1.2	1.8	5.9	-0.6	0.2	2.4	-0.0	0.4	-1.2	-2.1
Systolic Blood Pressure	1.2	6.2	14.7	-1.9	-3.8	-3.5	-3.0	-2.0	-0.2	0.6
Ever had hysterectomy (womb removed)	1.2	1.4	4.1	1.4	0.6	0.5	1.3	1.0	2.0	0.6
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	3.3	1.2	0.8	0.7	1.1	1.8	1.4	-0.2
Trunk fat percentage	1.2	4.7	6.6	-2.0	-2.2	-0.8	-2.4	-2.6	-2.4	-2.3
Hayfever/allergic rhinitis (self-reported)	1.2	1.5	2.9	-1.7	-1.6	-0.5	-0.7	-1.6	-1.3	0.3
Pulse wave Arterial Stiffness index	1.2	1.4	4.6	-1.5	0.4	1.1	0.0	-0.9	-0.7	-2.1
Number of children fathered	1.2	1.3	4.5	0.7	1.0	2.1	1.3	1.0	0.2	-0.6
Shortness of breath walking on level ground	1.2	1.5	3.9	-0.5	-1.0	-1.7	0.4	-0.2	1.5	2.0
Average weekly red wine intake	1.2	1.8	4.1	1.2	1.5	1.2	2.0	0.3	1.7	0.0
Supplements: Fish oil (including cod liver oil)	1.2	1.6	4.6	2.1	0.9	-0.4	0.1	1.2	1.7	1.1
Unable to work because of sickness or disability	1.2	1.5	3.6	-0.5	-1.9	-1.8	-1.1	-0.7	-0.4	1.2
Triglycerides	1.1	1.9	4.5	1.8	0.2	-1.3	0.5	1.3	2.1	1.3
Waist Hip Ratio (WHR)	1.1	5.1	15.8	1.7	1.3	-0.8	2.6	0.7	4.0	2.6
Qualifications: CSEs or equivalent	1.1	1.4	3.2	1.2	0.5	0.5	1.2	1.8	1.8	0.6
Hearing difficulty/problems with background noise	1.1	1.7	6.7	-0.2	-2.6	-1.5	-1.3	-0.7	-0.7	0.4
Illnesses of siblings	1.1	1.5	6.2	1.1	1.2	1.1	2.5	0.4	0.6	-0.6
Trunk fat-free mass	1.1	6.3	11.8	2.2	3.4	3.4	2.7	1.8	2.5	-0.2
Trunk predicted mass	1.1	6.1	11.4	2.1	3.4	3.3	2.6	1.7	2.4	-0.2
Chronic bronchitis/emphysema (mother)	1.1	1.2	2.1	-1.4	-0.7	-1.2	-1.4	-1.4	-1.0	-0.2
Pulse wave peak to peak time	1.1	1.3	4.5	1.4	-0.2	-0.9	0.1	0.9	0.8	2.1
Heart disease (mother)	1.1	1.3	3.8	1.7	0.5	0.1	-0.1	2.0	1.4	0.5
Medication: Aspirin	1.1	1.4	2.3	1.5	0.9	1.2	1.1	1.4	1.4	0.7
Osteoporosis (self-reported)	1.1	1.3	2.6	1.4	0.8	-0.8	0.5	1.2	1.4	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	4.5	-2.1	-1.4	-2.0	-1.3	-1.9	-0.2	-0.1
High cholesterol (Self-reported)	1.1	2.0	5.5	0.2	-1.5	-2.3	-1.3	-0.4	1.0	1.8
Myopia	1.1	1.5	4.5	-0.9	-2.1	-1.4	-1.1	-1.4	-0.4	0.4
Coronary Artery Disease (CAD)	1.0	1.2	2.3	1.4	-0.5	-0.6	0.5	1.1	1.5	1.5
Primary Biliary Cirrhosis	1.0	1.4	5.6	-0.9	-0.4	-1.0	-2.4	-0.7	-1.1	0.5
Chronotype (morning person)	1.0	2.3	4.6	2.1	1.1	1.1	2.1	1.3	1.8	0.5
Number of treatments/medications taken	1.0	1.7	4.4	0.5	-0.5	-1.2	-1.1	1.1	1.8	2.1
Average weekly spirits intake	1.0	1.2	2.6	0.9	1.5	1.6	1.5	0.2	0.3	-0.5
Other serious medical condition/disability diagnosed by doctor	1.0	1.2	2.1	-1.4	-1.4	-1.2	-1.1	-0.9	-1.1	0.3
Pain all over the body in last month	1.0	1.1	2.3	1.5	0.8	0.4	1.1	1.3	1.1	-0.5
Medication: Cholesterol lowering	1.0	1.5	2.8	1.1	-0.7	-1.7	-0.3	1.2	1.5	1.5
Tense / ‘highly strung’	1.0	1.6	3.9	1.2	0.6	-0.2	1.9	0.6	2.0	1.2
Birth weight of first child	1.0	1.9	5.2	1.5	1.1	2.3	1.6	1.2	0.2	-0.7
Peak expiratory flow (PEF)	1.0	2.2	4.4	-2.1	-2.0	-0.8	-0.7	-1.8	-1.4	-0.9
Loud music exposure frequency	1.0	1.0	1.7	-1.3	0.8	0.8	1.2	-0.6	-1.1	-1.1
Comparative body size at age 10	1.0	2.6	6.2	-0.8	-2.5	-1.2	-1.0	-1.1	-2.0	-2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.6	0.7	1.2	0.9	1.6	0.5	1.5	0.7
Pack years of smoking	1.0	1.4	3.0	-0.8	1.2	1.6	1.2	0.0	-1.0	-1.7
Ulcerative Colitis (UC)	0.9	1.6	3.7	1.3	0.4	1.9	1.0	1.3	1.0	-1.5
Bipolar Disorder (2011)	0.9	0.9	3.2	0.8	-0.3	-1.4	0.2	0.2	0.7	1.8
LDL Cholesterol	0.9	1.4	4.4	-0.4	-2.1	-2.1	-0.9	-0.4	-0.1	-0.1
Pack years adult smoking proportion	0.9	1.4	3.3	-0.5	1.3	1.8	1.6	0.0	-0.6	-1.3
Maternal smoking around birth	0.9	1.3	2.2	-1.5	-1.4	-1.2	-0.7	-1.4	-0.8	-0.3
High blood pressure	0.9	2.5	3.9	-1.6	-1.9	-2.0	-1.7	-1.9	-0.7	-0.5
Chronic bronchitis/emphysema (father)	0.9	1.1	1.6	1.3	-1.2	-0.8	0.1	1.2	1.0	1.1
Pulse rate	0.9	1.5	6.1	-0.7	-0.2	1.2	1.3	-0.6	-0.6	-2.5
Prospective memory result	0.9	1.1	2.5	-1.2	-1.6	-1.3	-0.2	-1.2	-0.3	0.7
Length of working week for main job	0.9	1.0	3.7	-0.1	1.1	1.9	0.7	0.4	-0.7	-0.8
Hair/balding pattern: Pattern 4	0.9	2.1	8.4	0.4	0.4	-0.8	0.7	-0.5	2.1	2.9
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	3.1	1.5	0.9	1.8	1.6	1.7	0.7	-0.5
Mouth/teeth dental problems: Loose teeth	0.9	1.1	3.3	0.3	1.4	1.8	0.1	0.9	-0.5	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.2	-0.9	0.9	0.6	-1.3	-1.1	-1.5	-0.7
Illness, injury, bereavement, stress in last 2 years	0.9	1.0	2.9	-0.4	-0.1	-1.6	-1.3	-0.1	0.2	1.7
Supplements: Vitamin C	0.9	1.1	2.5	1.6	0.6	-0.0	0.9	1.2	1.4	0.4
Whole body fat-free mass	0.9	4.9	10.4	1.9	3.1	3.2	2.3	1.4	1.9	-0.5
Commuting to job workplace: Walk	0.9	1.0	2.3	1.0	1.5	0.5	1.0	0.2	1.4	0.7
Medication: Gliclazide	0.9	1.0	2.5	0.4	0.9	1.6	1.0	1.0	1.1	-0.5
Whole body water mass	0.9	4.9	9.8	1.9	3.0	3.1	2.3	1.4	2.1	-0.4
Medication: Atorvastatin	0.9	1.1	3.7	1.3	0.4	0.0	0.4	1.9	1.2	0.9
Vascular/heart problems diagnosed by doctor	0.9	2.5	4.4	1.6	1.5	1.9	2.1	2.1	0.6	0.3
Heart disease (siblings)	0.9	1.1	3.2	0.8	1.4	1.8	-0.2	0.9	0.3	-1.0
Arm predicted mass (left)	0.9	4.4	8.4	1.9	2.9	2.7	2.2	1.1	2.3	-0.1
Irritable Bowel Disease (IBD)	0.8	1.9	5.1	1.3	0.6	2.2	0.8	1.7	0.6	-1.5
Major Depression (MDD)	0.8	0.9	3.1	-0.3	-1.7	-1.7	-0.0	0.4	0.3	0.6
Cardiovascular Disease	0.8	2.7	7.1	-1.1	-2.7	-2.4	-1.5	-1.3	-0.4	0.7
Frequency of depressed mood in last 2 weeks	0.8	1.1	3.3	-1.4	-0.6	0.2	0.6	-1.8	-0.7	-1.2
Diabetes (mother)	0.8	1.0	3.2	0.9	0.3	0.4	1.8	0.6	1.4	0.6
Body fat percentage	0.8	3.2	5.8	-1.6	-1.4	-0.0	-1.7	-2.2	-2.0	-2.4
Arm fat-free mass (right)	0.8	4.3	9.0	1.9	3.0	2.4	2.2	1.1	2.3	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	3.2	1.1	0.6	0.6	1.8	0.1	0.8	-0.7
Arm predicted mass (right)	0.8	3.9	7.3	1.9	2.7	2.5	2.1	1.0	2.2	-0.1
Eye problems/disorders: Cataract	0.8	0.9	1.8	-0.2	-0.9	-1.4	-1.1	-1.3	-0.2	-0.9
Medication: Paracetamol	0.8	1.2	2.7	0.5	-1.0	-0.8	-1.2	0.9	1.3	1.6
Basal cell carcinoma (self-reported)	0.8	1.0	2.8	0.9	0.3	0.5	1.7	0.9	1.3	0.7
HbA1C	0.7	0.8	2.3	-0.4	-1.5	-0.7	0.7	-0.6	-0.4	-1.2
Blood Red Count	0.7	7.1	15.1	3.0	3.9	1.3	0.9	2.2	3.7	2.2
Systolic blood pressure, automated reading	0.7	2.1	5.3	-0.9	-2.3	-1.8	-1.4	-1.8	0.6	0.0
Angina	0.7	1.0	3.0	0.6	1.7	0.3	0.5	1.0	1.3	0.6
Severe depression (siblings)	0.7	0.8	2.6	-0.2	-1.4	-0.4	-0.7	-0.2	-0.4	1.6
Hand grip strength (right)	0.7	2.0	7.2	0.2	2.7	1.9	1.3	-0.3	-0.2	-1.1
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.9	0.1	0.2	-0.0	-0.3	0.8	1.5	1.7
Medication: Atenolol	0.7	0.9	3.2	-0.7	-1.1	-0.5	-1.8	-0.8	-0.6	0.4
Number of incorrect matches in round	0.7	1.1	4.3	0.3	2.1	1.1	1.4	0.4	0.2	0.0
Mouth/teeth dental problems	0.7	1.1	2.5	-1.3	-1.2	-1.0	-0.8	-1.6	-0.6	-0.2
Time employed in main current job	0.7	0.8	1.5	1.2	1.0	0.6	1.1	1.0	0.7	0.1
Alcohol intake versus 10 years previously	0.7	1.1	2.8	1.0	0.6	-0.5	0.1	1.0	1.7	1.5
Breastfed as a baby	0.7	0.9	2.0	-1.4	-0.2	1.4	-0.3	-0.2	-1.4	-0.4
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.6	1.3	0.9	0.5	0.6	1.9	0.8	0.6
Alcohol intake frequency.	0.7	1.5	3.4	-1.7	-0.2	-1.0	-1.9	-1.0	-1.4	0.6
Hypertension (Self-reported)	0.7	1.8	3.1	-1.5	-1.6	-1.6	-1.3	-1.8	-0.6	-0.2
Illnesses of siblings: Diabetes	0.7	0.9	4.9	-0.6	0.5	-0.5	-2.2	0.1	0.3	0.7
Loneliness, isolation	0.7	0.9	2.4	-0.1	0.0	1.5	0.7	-0.6	-0.9	-1.6
Friendships satisfaction	0.7	0.9	1.8	0.9	0.5	1.4	1.2	1.3	0.3	0.5
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	3.6	-0.4	-1.1	-1.9	-1.1	0.5	0.2	1.3
Medication: Aspirin	0.7	0.9	1.7	1.1	0.7	1.3	0.7	1.3	0.9	0.4
Illnesses of father: None of the above (group 1)	0.7	0.8	2.2	1.0	0.8	1.5	0.1	1.4	-0.3	-0.5
Financial situation satisfaction	0.7	0.8	2.8	-1.0	-1.7	0.2	-0.5	-0.9	-0.9	-0.0
Eye problems/disorders: Glaucoma	0.7	0.8	1.9	-1.1	-0.3	1.4	-0.1	-0.7	-0.7	-1.3
Basal metabolic rate	0.7	3.7	8.9	1.5	2.7	3.0	1.9	0.9	1.5	-0.8
Arm fat-free mass (left)	0.7	3.8	8.0	1.5	2.8	2.7	2.2	0.7	2.0	-0.3
Supplements: Calcium	0.7	0.8	1.9	0.8	0.0	-0.7	1.2	0.6	1.4	0.7
Intelligence (Savage-Jansen 2018)	0.6	2.0	4.4	1.4	0.9	-0.7	0.7	1.7	2.1	1.6
Breast Cancer	0.6	1.4	4.7	-1.7	-0.5	-0.1	-0.4	-2.2	-1.0	-0.8
Ulcerative Colitis	0.6	0.9	3.2	1.8	0.2	0.3	0.9	1.1	1.0	0.4
Sensitivity / hurt feelings	0.6	1.0	5.1	-0.5	-0.3	0.5	0.9	-0.4	-0.6	-2.3
Leg fat-free mass (left)	0.6	3.1	8.1	1.5	2.3	2.8	1.6	0.9	1.2	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.4	-1.2	-0.9	-0.4	0.1	-1.0	-1.1	-0.7
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.8	0.8	1.3	0.3	0.1	1.0	0.1	0.9
Leg predicted mass (left)	0.6	3.0	7.9	1.5	2.3	2.8	1.6	0.9	1.2	-0.8
Heart attack	0.6	0.7	1.7	0.5	-0.8	-1.3	-1.2	0.0	0.4	0.9
Arm fat percentage (right)	0.6	2.3	4.8	-1.3	-1.0	0.4	-1.6	-1.6	-1.9	-2.2
Falls in the last year	0.6	0.8	2.3	1.5	-0.4	0.9	0.2	1.4	0.2	0.6
Number of live births	0.6	0.8	2.1	1.4	0.4	1.2	0.7	1.1	0.5	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	3.1	1.1	0.2	0.6	0.7	1.8	0.7	0.4
Medication: Paracetamol	0.6	1.0	1.7	1.2	-0.7	-0.2	-0.9	1.2	1.0	1.3
Eye problems/disorders: None of the above	0.6	0.6	2.1	0.7	0.9	0.9	0.1	0.4	0.2	1.4
Knee pain experienced in last month	0.6	0.9	4.7	0.0	-0.5	-0.4	-2.2	0.7	0.2	0.6
Smoking status: Previous	0.6	0.9	1.8	1.4	-1.0	0.7	0.3	1.1	1.3	-0.4
Mood swings	0.6	1.1	3.3	1.5	-0.2	-0.4	0.9	0.7	1.8	-0.7
Breast cancer (self-reported)	0.6	0.8	2.3	-0.4	0.5	0.1	1.5	-1.5	0.5	0.4
Age started oral contraceptive pill	0.6	0.8	1.9	0.2	1.0	1.4	0.5	0.3	-0.3	-1.4
Cholesterol lowering medication	0.6	0.8	2.8	1.0	0.1	-0.6	0.2	0.2	1.7	1.3
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.1	0.9	0.8	0.6	0.8	1.1	0.8	-0.8
Alcohol drinker status: Previous	0.6	0.7	1.8	-1.4	0.5	0.6	0.5	0.1	-1.3	-0.7
Neuroticism (2016)	0.5	0.7	2.1	-0.9	-1.5	-0.8	0.9	-0.0	-0.4	-0.5
Blood Eosinophil Count	0.5	3.5	8.8	0.8	3.0	2.2	2.5	1.2	0.1	-1.7
Blood Platelet Count	0.5	5.4	13.0	-0.9	-3.6	-2.8	-2.7	1.1	-0.4	2.8
BMI	0.5	2.8	6.9	0.5	2.0	2.6	0.0	-0.5	-1.3	-2.6
Lung FEV1/FVC ratio	0.5	2.5	4.4	0.6	2.0	2.1	2.1	1.3	1.3	-1.0
Hand grip strength (left)	0.5	1.2	4.8	0.6	2.2	1.1	0.9	0.5	0.7	0.7
Medication: Co-codamol	0.5	0.6	1.8	0.6	1.4	1.4	0.2	0.4	0.4	0.1
Current tobacco smoking	0.5	0.8	1.6	0.1	1.3	1.3	1.1	0.3	0.1	-0.9
Age when periods started (menarche)	0.5	1.1	5.0	0.8	-0.8	0.1	-0.6	2.2	0.7	0.8
Multivitamins +/- minerals	0.5	0.6	1.5	0.1	-1.2	-0.9	-1.2	0.3	0.2	0.5
Stomach or abdominal pain in last month	0.5	0.7	1.4	0.3	1.0	0.7	1.2	1.0	0.8	0.4
Medication: Levothyroxine sodium	0.5	0.9	2.8	0.4	-0.3	1.1	1.0	0.7	-0.5	-1.7
Trunk fat mass	0.5	2.1	4.5	-1.2	-1.0	0.3	-1.5	-1.8	-1.4	-2.1
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	2.8	-0.7	-0.7	0.6	0.1	-0.9	-0.6	-1.7
Hair/balding pattern: Pattern 2	0.5	0.7	2.4	0.3	1.6	0.6	1.3	-0.3	0.4	-0.1
Had other major operations	0.5	0.6	2.6	1.0	0.4	-0.4	0.5	0.1	1.6	0.4
Fluid intelligence score	0.5	1.0	2.7	0.8	-0.1	-1.1	-0.5	1.7	1.0	0.9
Father’s age at death	0.5	0.7	1.5	-0.6	-0.5	-0.9	-1.2	-0.3	-1.0	1.0
Hair/balding pattern: Pattern 3	0.5	0.7	1.9	0.4	-0.9	1.1	-0.1	0.4	-0.9	-1.4
Glaucoma (self-reported)	0.5	0.5	2.6	-0.4	-0.4	1.6	-0.1	-0.1	-0.1	-0.9
Gout (self-reported)	0.5	0.6	1.2	0.9	0.8	-0.7	0.6	0.8	0.4	1.1
Leg fat percentage (right)	0.5	1.9	5.4	-1.0	0.1	1.4	-0.7	-1.7	-1.3	-2.3
Exposure to tobacco smoke outside home	0.5	0.7	1.5	-0.8	-0.1	1.1	-0.4	-0.5	-1.2	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	2.4	-0.8	-0.4	-0.9	-0.4	-1.5	-0.9	0.1
Wheeze or whistling in the chest in last year	0.5	0.9	2.3	0.9	1.5	1.0	0.9	0.4	0.9	0.8
Medication: Blood pressure	0.5	0.9	2.1	-0.6	-1.4	-1.4	-0.8	-0.8	-0.4	-0.3
Number of full sisters	0.5	0.6	2.8	-0.4	0.4	-0.1	-0.3	-1.7	-0.1	-0.8
Had major operations	0.5	0.5	1.3	-0.4	-1.0	-1.2	-0.9	-0.5	0.0	-0.4
Family relationship satisfaction	0.5	0.6	3.5	-0.6	-0.3	0.5	0.1	0.4	-1.9	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	0.9	2.3	-1.3	-0.3	0.2	1.1	-1.5	-0.3	-1.0
Leg fat-free mass (right)	0.5	2.9	7.3	1.5	2.4	2.7	1.7	1.0	1.1	-0.5
Arm fat percentage (left)	0.5	1.9	4.7	-1.0	-0.8	0.4	-1.6	-1.4	-1.6	-2.2
Ever had bowel cancer screening	0.5	0.5	1.2	0.2	1.1	1.0	0.5	0.3	0.8	-0.7
Leg predicted mass (right)	0.5	2.7	6.8	1.5	2.3	2.6	1.6	0.9	1.1	-0.5
Average weekly champagne plus white wine intake	0.5	0.7	3.5	-0.5	-1.9	-0.2	0.0	-0.8	-0.2	-0.7
Mother’s age at death	0.5	0.7	1.5	-0.5	0.0	1.1	1.2	0.2	-0.6	-1.1
Leg fat percentage (left)	0.5	1.7	4.2	-1.1	0.2	1.1	-0.7	-1.8	-1.4	-2.0
Fractured/broken bones in last 5 years	0.5	0.6	3.2	0.3	0.5	0.4	-0.0	-0.3	-0.5	-1.8
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.3	0.6	-0.7	-1.1	-1.1	0.2	0.5	0.9
Crohns Disease (2017)	0.4	0.9	3.5	0.7	0.7	1.9	0.5	1.1	-0.4	-0.8
Body Mass Index (BMI) (2010)	0.4	0.5	1.5	0.8	-0.3	-1.2	-1.2	0.3	0.1	0.1
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.2	0.5	1.1	0.8	0.2	0.9	0.6	-0.3
Smoking Status	0.4	1.0	3.5	-0.3	-0.5	1.2	1.0	-0.6	0.3	-1.9
Neuroticism	0.4	1.0	2.6	1.1	-0.6	-0.4	1.2	1.0	1.6	-0.1
Vitamin and mineral supplements	0.4	0.5	1.7	-1.2	-0.1	-0.2	0.2	-1.3	-0.7	0.0
Body mass index (BMI)	0.4	1.7	5.4	0.4	2.0	2.3	-0.1	-0.3	-0.4	-1.4
Waist circumference	0.4	1.4	2.7	1.3	1.6	1.5	1.0	-0.1	1.4	-0.2
Neuroticism score	0.4	0.8	2.6	0.9	-0.1	0.4	1.6	0.7	1.0	-0.8
Hip circumference	0.4	1.6	5.1	-0.1	0.3	1.7	-1.0	-1.0	-1.1	-2.2
Worrier / anxious feelings	0.4	0.7	2.6	0.7	-0.7	0.6	1.6	0.1	0.8	-0.8
Asthma	0.4	0.7	2.4	0.8	1.0	-0.9	-0.3	0.0	0.1	1.6
Exposure to tobacco smoke at home	0.4	0.4	1.9	0.4	0.7	1.4	0.6	-0.3	-0.1	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.6	1.0	0.7	0.8	1.2	0.2	1.0	-0.5
Medication: Amlodipine	0.4	0.5	1.7	0.6	-0.0	0.7	-0.2	1.3	1.0	0.3
Health satisfaction	0.4	0.6	1.6	-0.3	0.9	1.1	1.3	0.1	-0.2	-0.4
Medication: Seretide 50 evohaler	0.4	0.4	1.0	0.2	0.9	-0.7	-1.0	0.4	0.5	0.6
Leg fat mass (right)	0.4	1.6	5.4	-0.3	0.9	1.9	0.0	-1.0	-0.6	-2.3
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.2	0.8	-0.4	-0.5	-0.3	1.1	0.6	0.8
Back pain experienced in last month	0.4	0.7	2.2	1.0	-0.2	0.7	1.5	0.7	0.3	-0.5
Number of operations (self-reported)	0.4	0.5	1.8	0.6	1.0	-0.1	0.7	0.3	1.3	0.2
Risk taking	0.4	0.5	1.5	-0.8	0.7	1.2	-0.1	-0.4	-1.0	0.2
Pain experienced in last month	0.4	0.6	1.3	-0.8	0.3	-0.3	-0.8	-1.1	-1.2	-0.2
Leg fat mass (left)	0.4	1.6	5.1	-0.6	0.8	1.6	-0.2	-1.4	-0.9	-2.2
Neuroticism (Nagel 2018)	0.3	0.6	2.0	0.6	-0.3	0.3	1.4	0.4	1.0	-0.7
Alzheimer’s Disease (in mother)	0.3	0.4	0.5	-0.7	-0.5	0.0	-0.6	-0.6	-0.7	-0.7
Alzheimer’s Disease (in father)	0.3	0.3	1.2	-0.6	-0.0	-0.8	0.3	-1.1	0.2	-0.0
Alzheimer’s Disease (including proxy)	0.3	0.4	0.8	-0.4	0.9	0.2	0.5	-0.8	0.1	-0.8
Fasting Glucose	0.3	0.4	2.0	-0.4	0.1	1.4	-0.2	-0.7	0.0	-0.3
Blood White Count	0.3	1.9	7.1	0.9	2.7	2.0	0.8	-0.1	0.8	-0.5
Hypothyroidism (self reported)	0.3	0.7	1.9	0.7	0.2	1.1	1.4	0.9	0.1	-0.2
Respiratory disease	0.3	0.6	1.2	1.1	1.0	-0.9	-0.2	0.6	0.3	0.9
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.3	1.1	0.3	-0.2	0.4	0.9	0.5	-0.4
Relative age voice broke	0.3	0.4	1.1	0.2	0.3	0.3	0.2	1.0	0.9	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	3.3	0.5	0.6	-0.6	-0.7	0.6	0.3	1.8
Past tobacco smoking	0.3	0.6	1.5	-0.6	0.7	-1.2	-0.1	-0.7	-0.4	1.0
Allergy	0.3	0.8	2.7	-0.5	-1.2	-0.1	-1.6	-0.7	-0.5	-0.4
Medication: Ramipril	0.3	0.4	1.8	0.6	1.3	0.1	-0.2	0.3	0.2	0.6
Weight	0.3	1.5	5.2	0.3	1.4	2.3	0.5	-0.4	0.1	-1.6
Depression (self-reported)	0.3	0.4	1.0	-0.4	-0.2	-1.0	0.2	-1.0	0.7	0.5
Arm fat mass (right)	0.3	1.1	3.9	-0.3	0.3	1.5	-0.5	-0.9	-0.8	-2.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.6	-0.7	-0.8	-0.4	-0.5	-0.7	-0.6	0.4
Worry too long after embarrassment	0.3	0.5	0.9	-1.0	0.5	0.3	-0.1	-0.8	-0.9	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.6	-0.6	0.7	0.1	-0.2	-0.8	-0.7	0.1
Whole body fat mass	0.3	1.4	5.2	-0.5	0.0	1.2	-0.5	-1.2	-0.9	-2.3
Comparative height size at age 10	0.3	1.6	3.9	1.4	0.8	0.8	2.0	0.5	1.9	-0.1
Chest pain or discomfort	0.3	0.4	1.6	-0.2	0.5	-0.4	-0.2	-0.6	-0.4	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.2	-0.9	-0.2	-0.1	-0.2	-0.4	-0.2	-1.1
Illnesses of father: Heart disease	0.3	0.4	0.9	-0.1	-0.7	-0.7	0.7	-0.4	0.9	0.4
Medication for cholesterol	0.3	0.5	1.8	0.7	0.5	0.4	1.3	0.6	-0.1	-0.4
Asthma (self-reported)	0.3	0.6	1.7	0.4	0.7	-1.2	-0.5	-0.3	-0.2	1.3
Smoking status: Current	0.3	0.5	1.2	-0.2	1.0	1.1	0.7	0.1	0.0	-0.9
Number of self-reported non-cancer illnesses	0.3	0.5	1.3	-0.4	-1.1	-0.9	-0.9	-0.4	0.3	-0.1
Wears glasses or contact lenses	0.3	0.3	1.1	-0.7	-1.1	0.3	-0.5	-0.2	0.1	-0.4
Illnesses of father: High blood pressure	0.3	0.4	1.5	-0.4	-0.4	-1.0	-0.4	-1.2	0.1	0.0
Irritability	0.3	0.5	1.4	0.3	-1.1	-0.3	1.2	0.7	0.1	-0.0
Bipolar Disorder (2018)	0.2	0.3	0.9	0.6	0.0	-0.4	0.2	0.1	0.8	1.0
Bipolar Disorder or Schizophrenia	0.2	0.5	1.3	0.6	0.9	0.1	-0.0	0.6	0.7	1.1
Depressed Affect (Nagel 2018)	0.2	0.3	1.0	0.7	-0.3	-0.0	0.7	0.3	1.0	-0.4
Depression (Nagel 2018)	0.2	0.3	1.1	-0.3	-0.3	0.0	1.0	-0.6	0.1	-0.8
Schizophrenia (2018)	0.2	0.4	1.2	0.3	1.1	0.5	-0.1	0.8	0.1	0.7
Schizophrenia vs Biploar Disorder	0.2	0.3	1.0	-0.0	0.1	0.8	0.0	0.0	-0.4	-1.0
Ovarian Cancer	0.2	0.2	0.7	-0.5	-0.6	0.1	0.3	-0.2	0.3	0.9
Crohns Disease (2012)	0.2	0.4	1.3	0.8	-0.5	-0.3	-0.4	0.5	0.3	1.1
Schizophrenia (2014)	0.2	0.4	1.0	0.6	1.0	0.4	0.3	0.9	0.0	0.8
Heel T-Score	0.2	2.0	6.9	1.2	-0.8	-1.4	-1.3	0.3	1.0	2.6
Allergy or Eczema	0.2	0.4	1.4	-0.4	-0.6	-0.4	1.2	-0.5	-0.5	-0.7
Lung FVC	0.2	0.9	2.2	0.3	1.5	1.2	1.2	0.4	0.8	-0.6
Hair Pigment	0.2	4.6	9.5	-3.1	-2.7	-2.0	-2.5	-2.3	-0.6	0.2
Tanning	0.2	2.8	4.5	-2.1	-1.1	-1.9	-1.5	-2.1	-1.9	-0.7
Relative age of first facial hair	0.2	0.4	0.9	-0.9	-0.6	0.2	-0.8	1.0	-0.4	-0.3
Townsend deprivation index at recruitment	0.2	0.3	0.6	-0.7	-0.4	-0.6	-0.5	0.0	-0.2	0.8
Average weekly fortified wine intake	0.2	0.3	1.0	-0.3	0.1	0.7	-0.0	0.1	-1.0	-0.6
Fed-up feelings	0.2	0.4	1.8	-0.3	-0.1	0.6	0.1	-0.4	-0.7	-1.4
Serious illness, injury or assault to yourself	0.2	0.3	0.9	-0.1	-0.3	-0.7	0.3	-0.9	0.1	-0.4
Hayfever, allergic rhinitis or eczema	0.2	0.3	2.3	-0.1	0.2	-0.0	1.5	0.0	-0.0	0.1
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.6	-0.4	-0.0	0.8	-0.1	-0.2	0.7	0.4
High blood pressure (mother)	0.2	0.3	1.5	0.1	-1.2	-0.3	-0.2	-0.8	-0.3	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	2.4	0.4	0.5	-0.3	-1.6	0.2	-0.4	0.7
Happiness	0.2	0.3	0.5	-0.7	-0.7	0.2	0.4	-0.5	-0.4	0.6
Noisy workplace	0.2	0.3	0.9	-0.3	0.9	0.3	0.0	0.0	-0.0	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.7	0.4	0.3	-0.1	0.8	0.3	0.5	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	2.7	-0.4	-0.9	-0.7	0.7	0.3	1.6	0.7
Pulse wave reflection index	0.2	0.3	0.8	-0.6	0.2	-0.6	-0.9	-0.4	-0.2	-0.3
Blood clot in the leg (DVT)	0.2	0.2	0.9	-0.0	0.3	0.6	0.2	0.5	0.4	-0.9
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.7	-0.3	0.5	1.3	0.4	-0.1	-0.7	-0.3
Forced vital capacity (FVC), Best measure	0.2	0.6	2.2	-0.1	-0.4	-0.3	1.2	0.4	1.5	0.4
Pulse rate, automated reading	0.2	0.5	1.5	0.4	-0.8	-0.8	0.6	0.2	1.2	0.2
Leg pain on walking	0.2	0.3	0.7	-0.9	-0.7	-0.6	-0.2	-0.1	-0.4	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	-0.5	-0.2	0.3	0.5	-0.6	0.3	0.3
Arm fat mass (left)	0.2	0.9	3.0	-0.2	0.6	1.4	-0.6	-0.7	-0.5	-1.7
Guilty feelings	0.2	0.4	1.5	-0.3	-0.9	-0.3	0.2	0.0	0.2	-1.2
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.7	0.4	-0.3	0.9	0.5	-0.2	-0.3	-0.3
Medication: Blood pressure	0.2	0.4	1.6	-0.4	0.1	-0.1	-1.3	0.2	-0.0	1.0
Medication: Bendroflumethiazide	0.2	0.2	1.0	0.2	1.0	0.5	-0.6	-0.0	0.3	-0.2
Medication: Lisinopril	0.2	0.3	1.1	-0.2	0.6	0.6	-0.2	1.1	0.1	-0.2
Ever smoked	0.2	0.4	1.1	0.7	-0.5	1.0	0.0	0.6	0.2	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	1.2	-0.1	-0.2	0.5	0.1	0.2	0.0	-1.1
Reaction Time	0.1	0.3	1.4	0.2	1.2	-0.0	0.4	0.3	-0.1	-0.3
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.5	0.4	0.5	-0.2	0.1	1.2	0.3	-0.3
Age at First Birth	0.1	0.1	0.3	0.2	-0.1	0.1	-0.3	-0.3	-0.6	-0.4
Rheumatoid Arthritis	0.1	0.2	0.4	0.3	0.2	0.6	-0.6	0.6	-0.3	-0.3
Height	0.1	2.8	5.5	1.2	-0.0	2.3	2.2	1.6	1.9	-1.3
Taking other prescription medications	0.1	0.1	0.6	-0.0	0.8	0.0	-0.5	0.0	0.0	0.3
Sitting height	0.1	0.4	1.2	-0.7	-1.1	-0.6	0.5	0.2	0.6	0.3
Alcohol usually taken with meals	0.1	0.2	0.8	0.2	0.3	0.3	0.9	0.0	0.6	0.3
Had menopause	0.1	0.1	0.3	-0.3	-0.5	-0.1	-0.3	0.1	-0.5	-0.3
Forced vital capacity (FVC)	0.1	0.3	0.6	-0.6	-0.6	-0.2	0.8	-0.4	0.7	-0.1
Qualifications: None of the above	0.1	0.2	0.9	0.4	0.3	1.0	0.4	0.4	0.1	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.5	0.0	-0.6	-0.2	-0.7	0.5	-0.1	-0.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	1.1	-1.1	-0.9	-0.4	0.5	-0.7	0.6	-0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.8	0.1	-0.2	0.4	0.7	0.9	0.4	0.2
Illnesses of mother	0.1	0.1	0.4	0.3	0.7	0.4	-0.1	0.3	0.1	-0.0
Standing height	0.1	0.7	1.7	-0.2	-1.3	0.1	1.1	0.0	1.1	-0.7
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.4	0.1	-0.1	0.6	0.4	0.1	-0.5	-0.5
Headache pain in last month	0.1	0.2	0.9	0.2	-0.9	0.0	-0.2	0.6	0.4	-0.0
Birth weight	0.1	0.3	0.7	0.8	0.4	0.2	0.5	0.8	-0.6	0.1
Qualifications: College or University degree	0.1	0.5	1.7	0.1	0.2	0.4	1.3	0.5	0.8	-0.7
Medication: Allopurinol	0.1	0.2	0.4	-0.1	0.7	-0.7	0.4	0.0	0.0	0.5
Medication: Omeprazole	0.1	0.2	0.8	0.1	0.1	-0.1	0.1	0.2	0.5	-0.9
Mean time to correctly identify matches	0.1	0.2	0.7	-0.4	0.8	-0.1	-0.0	-0.2	-0.5	-0.3
Overall health rating	0.1	0.3	0.6	0.3	0.2	0.8	0.1	0.5	0.7	0.6
Age at last live birth	0.1	0.1	0.6	0.2	-0.8	-0.0	0.3	0.3	0.3	-0.1
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.4	-0.1	-0.6	-0.2	-0.5	0.1	-0.6	-0.1
Long-standing illness, disability or infirmity	0.1	0.2	0.5	-0.0	0.0	-0.6	-0.2	0.5	0.1	0.7
Qualifications: nursing, teaching	0.1	0.1	0.2	-0.3	0.3	0.2	0.4	0.5	-0.1	0.4
Osteoarthritis (self-reported)	0.1	0.2	0.7	0.4	-0.2	0.3	-0.1	0.2	0.8	-0.3
Miserableness	0.1	0.2	0.6	0.1	-0.3	-0.1	0.6	0.8	-0.1	-0.2
Commuting to job workplace: Public transport	0.1	0.1	0.2	0.0	-0.2	-0.1	0.5	0.4	0.4	0.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at first live birth	0.0	0.0	0.2	0.0	-0.1	0.2	0.2	0.1	-0.2	-0.5
Migraine (self-reported)	0.0	0.0	0.1	-0.2	0.1	-0.0	0.4	-0.2	0.1	-0.3

Hub : Genes

AKNA

Models

Trait associations