TWAS hub - ALMS1-IT1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Whole Blood	0.0520	0.0270	0.0065	0.011	NA	-0.001	NA	0.002	0.028	NA	0.4600	NA	0.2100
2	ROSMAP	Brain Pre-frontal Cortex	0.0365	0.0182	0.0020	0.011	0.028	0.016	0.03	0.015	0.011	0.00013	0.0033	9.1e-05	0.0039

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Prospective memory result	6.7	8.2	15.6	0.9	4.0
Qualifications: O levels/GCSEs or equivalent	6.6	10.4	12.4	-2.9	-3.5
Qualifications: nursing, teaching	6.5	10.0	15.5	-2.1	-3.9
Bipolar Disorder or Schizophrenia	5.9	14.3	27.4	1.1	5.2
Schizophrenia (2014)	5.8	12.9	24.6	1.1	5.0
Schizophrenia (2018)	4.4	9.1	18.3	0.1	4.3
Verbal and Numeric Reasoning (VNR)	4.4	10.6	18.6	-1.6	-4.3
Qualifications: A levels/AS levels or equivalent	4.4	9.8	12.1	-2.7	-3.5
Fluid intelligence score	4.2	8.7	17.0	-0.7	-4.1
Diastolic blood pressure, automated reading	4.2	13.1	17.9	2.9	4.2
Commuting to job workplace: Car/motor vehicle	4.1	4.7	6.9	-2.6	-1.6
Bipolar Disorder (2018)	3.8	6.1	9.2	1.7	3.0
Ever depressed for a whole week	3.8	4.6	5.6	2.4	1.9
Intelligence (Savage-Jansen 2018)	3.7	11.4	18.5	-2.1	-4.3
Lung FEV1/FVC ratio	3.7	18.8	26.9	5.2	3.3
Qualifications: College or University degree	3.7	11.6	17.2	-2.4	-4.2
Blood clot in the leg (DVT)	3.6	4.6	8.8	3.0	0.7
Deep venous thrombosis (DVT) (self-reported)	3.6	4.6	8.5	2.9	0.8
Smoking Status	3.5	8.4	13.0	1.9	3.6
Asthma	3.5	6.9	10.8	-3.3	-1.8
Qualifications: None of the above	3.2	6.9	11.1	1.6	3.3
Asthma (self-reported)	3.2	6.4	9.9	-3.1	-1.7
Medication: Seretide 50 evohaler	3.1	3.6	4.7	-2.2	-1.6
Townsend deprivation index at recruitment	2.9	4.1	7.7	0.6	2.8
Age at first live birth	2.9	5.2	5.9	-2.4	-2.1
Back pain experienced in last month	2.8	4.1	6.4	1.4	2.5
Respiratory disease	2.7	6.1	10.2	-3.2	-1.4
Maternal smoking around birth	2.6	3.7	7.0	2.6	0.6
Supplements: Vitamin C	2.6	3.1	6.1	-2.5	-0.4
Depression (Nagel 2018)	2.5	3.8	7.0	0.8	2.6
Chest pain or discomfort	2.5	3.5	7.1	-2.7	-0.2
Angina	2.4	3.1	4.9	1.2	2.2
Medication: Metformin	2.4	3.4	5.4	1.2	-2.3
Reason for reducing amount of alcohol drunk: Health precaution	2.4	2.8	4.1	1.2	2.0
Smoking status: Current	2.4	3.8	5.3	1.5	2.3
Medication: Ventolin 100micrograms inhaler	2.3	3.0	4.8	-2.2	-1.1
Wheeze or whistling in the chest in last year	2.2	3.9	5.4	-2.3	-1.6
Diabetes (self-reported)	2.1	3.3	5.4	2.3	-1.0
Diabetes diagnosed by doctor	2.1	3.5	3.7	1.8	-1.9
Number of operations (self-reported)	2.1	3.1	5.4	-2.3	-0.9
Angina (self-reported)	2.0	2.6	4.2	1.0	2.0
Illnesses of father: Heart disease	2.0	2.8	4.7	0.9	-2.2
Supplements: Calcium	2.0	2.2	2.2	-1.5	-1.5
Coronary Artery Disease (CAD)	1.9	2.3	4.1	0.7	2.0
Current tobacco smoking	1.9	3.1	4.1	1.4	2.0
Worry too long after embarrassment	1.9	3.2	6.2	-0.5	-2.5
Medication: Aspirin	1.9	2.5	3.7	1.9	1.1
Type 2 Diabetes (T2D) (2018)	1.8	3.3	4.5	1.5	-2.1
Ever had hysterectomy (womb removed)	1.8	2.0	2.1	1.4	-1.4
Eye problems/disorders: None of the above	1.8	2.1	4.0	2.0	-0.3
Chronic bronchitis/emphysema (father)	1.7	2.0	3.5	0.6	1.9
Serious illness, injury or assault of a close relative in last 2 years	1.7	1.9	2.9	1.7	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.4	8.1	2.9	1.6
Number of children fathered	1.7	1.9	3.2	1.8	-0.7
Osteoporosis (self-reported)	1.7	2.1	3.7	-0.7	-1.9
Fasting Glucose	1.6	1.9	2.0	1.3	1.4
Hayfever, allergic rhinitis or eczema	1.6	3.4	5.2	-2.3	-1.3
Illnesses of siblings	1.6	2.3	3.8	-1.9	-0.9
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.6	3.1	1.4	1.8
Noisy workplace	1.6	2.0	3.6	0.7	1.9
Number of full brothers	1.6	2.0	2.6	-1.2	-1.6
Migraine (self-reported)	1.6	2.0	3.8	1.9	0.5
Breast cancer (self-reported)	1.6	1.9	3.7	-1.9	0.1
Prostate Cancer	1.5	2.1	3.7	-0.8	1.9
Had other major operations	1.5	1.8	3.6	-1.9	0.1
Ever unenthusiastic/disinterested for a whole week	1.5	1.9	2.9	1.7	0.9
Birth weight of first child	1.5	2.6	5.3	2.3	-0.1
High blood pressure (siblings)	1.5	2.2	4.3	2.1	0.4
Shortness of breath walking on level ground	1.5	1.7	1.8	-1.3	-1.3
Mean time to correctly identify matches	1.5	2.9	4.3	2.1	1.2
Supplements: Zinc	1.4	1.5	2.4	-1.6	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	3.6	0.2	1.9
Number of incorrect matches in round	1.4	2.3	4.4	0.5	2.1
Allergy	1.4	3.3	3.3	1.8	1.8
Exposure to tobacco smoke at home	1.4	1.6	3.1	0.3	1.8
Handedness (chirality/laterality): Left-handed	1.4	1.6	2.5	0.9	1.6
Eye problems/disorders: Cataract	1.4	1.6	3.3	-1.8	0.0
Supplements: Fish oil (including cod liver oil)	1.4	1.8	2.0	1.3	1.4
Alzheimer’s Disease (in mother)	1.3	1.6	1.8	-1.3	-1.1
Mean Putamen Volume	1.3	1.4	2.6	-0.5	-1.6
Allergy or Eczema	1.3	3.4	5.0	-2.2	-1.3
Diabetes (mother)	1.3	1.7	3.1	1.8	0.5
Medication: Atenolol	1.3	1.6	3.1	0.4	1.8
Past tobacco smoking	1.3	2.3	4.6	-0.3	-2.1
Lung cancer (father)	1.3	1.5	2.0	1.0	1.4
Medication: Aspirin	1.3	1.7	2.9	1.7	0.8
Ever smoked	1.3	2.2	4.2	0.6	2.0
Cholesterol lowering medication	1.3	1.9	3.6	-1.9	0.5
Bipolar Disorder (2011)	1.2	1.2	1.7	1.3	0.8
Medication for hormone replacement therapy	1.2	1.4	1.9	1.4	-0.9
Average weekly fortified wine intake	1.2	1.4	2.3	0.7	-1.5
Taking other prescription medications	1.2	1.8	3.6	-0.0	-1.9
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	1.9	-1.4	-0.8
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	2.8	-1.7	-0.2
Illnesses of mother	1.2	1.4	2.1	-1.4	-0.9
Glaucoma (self-reported)	1.2	1.4	2.8	-1.7	0.2
Emphysema/chronic bronchitis	1.2	1.4	1.8	-1.0	-1.4
Overall health rating	1.2	2.5	4.8	0.4	2.2
Ulcerative Colitis (UC)	1.1	2.0	3.4	-0.8	1.9
Financial difficulties in last 2 years	1.1	1.5	2.4	1.6	0.8
Forced expiratory volume in 1-second (FEV1)	1.1	3.8	7.1	2.7	0.7
Birth weight	1.1	2.3	3.0	1.7	1.3
Mood swings	1.1	1.9	2.3	1.3	1.5
Mineral and other dietary supplements	1.1	1.5	2.2	-0.9	-1.5
Guilty feelings	1.1	1.7	2.4	-1.5	1.0
Medication: Bendroflumethiazide	1.1	1.6	2.5	0.9	1.6
Vascular/heart problems diagnosed by doctor	1.1	3.0	4.4	-1.2	-2.1
Heel T-Score	1.0	8.1	14.7	1.2	3.8
Medication: Cholesterol lowering	1.0	1.6	3.0	1.7	-0.5
Breastfed as a baby	1.0	1.2	2.4	-1.5	-0.1
Pulse rate, automated reading	1.0	3.1	3.9	2.0	1.5
Friendships satisfaction	1.0	1.2	1.5	-1.0	-1.2
Alzheimer’s Disease (in father)	0.9	1.0	1.5	-0.7	-1.2
Rheumatoid Arthritis	0.9	1.2	1.3	1.1	1.1
Triglycerides	0.9	1.5	1.5	1.2	-1.2
Qualifications: CSEs or equivalent	0.9	1.2	2.4	-0.1	1.6
Trunk fat mass	0.9	3.8	4.2	2.0	1.8
Alcohol usually taken with meals	0.9	1.5	3.0	-0.3	-1.7
Alcohol intake frequency.	0.9	2.0	3.8	-0.4	-2.0
Number of full sisters	0.9	1.1	1.6	-1.3	0.7
Average weekly beer plus cider intake	0.9	1.3	2.4	-0.5	1.5
Alcohol drinker status: Previous	0.9	1.0	2.0	-0.1	1.4
Alzheimer’s Disease (including proxy)	0.8	1.1	1.6	-1.3	-0.8
Age at First Birth	0.8	1.1	2.0	-1.4	-0.5
Body Mass Index (BMI) (2010)	0.8	1.2	2.3	1.5	-0.1
HDL Cholesterol	0.8	1.4	2.8	0.3	1.7
LDL Cholesterol	0.8	1.2	2.4	-0.0	-1.6
Lupus	0.8	1.2	2.0	-1.4	-0.7
Primary Biliary Cirrhosis	0.8	1.1	1.4	-0.9	-1.2
Sensitivity / hurt feelings	0.8	1.4	2.7	-1.6	0.4
Systolic blood pressure, automated reading	0.8	2.4	3.3	1.8	1.3
Pack years adult smoking proportion	0.8	1.2	2.2	-0.4	1.5
Trunk fat percentage	0.8	3.4	3.5	1.8	1.9
High blood pressure	0.8	2.3	3.0	1.2	1.7
Falls in the last year	0.8	1.1	1.8	1.4	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	1.8	1.3	0.8
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.0	0.1	1.4
Comparative height size at age 10	0.8	4.2	5.0	2.2	1.8
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.4	-0.8	-1.2
Average weekly red wine intake	0.8	1.1	2.3	-0.1	-1.5
Number of treatments/medications taken	0.7	1.2	2.3	1.5	0.2
Hair/balding pattern: Pattern 2	0.7	0.9	1.7	-1.3	0.1
Mouth/teeth dental problems	0.7	1.1	2.2	-0.0	-1.5
Father’s age at death	0.7	1.0	1.2	-1.1	-0.9
Hair/balding pattern: Pattern 3	0.7	1.0	1.3	0.8	1.2
Number of live births	0.7	1.0	1.3	1.1	0.8
Standing height	0.7	7.1	13.5	3.7	0.8
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.5	-0.0	1.2
Body fat percentage	0.7	2.9	3.2	1.6	1.8
Medication: Ibuprofen	0.7	0.8	0.9	0.9	0.9
Whole body fat mass	0.7	3.1	3.2	1.8	1.7
Commuting to job workplace: Walk	0.7	0.7	1.4	0.2	1.2
Leg fat percentage (left)	0.7	2.6	3.9	1.1	2.0
Age started oral contraceptive pill	0.7	0.9	1.0	0.9	1.0
Reaction Time	0.6	1.1	1.8	1.3	0.7
Ulcerative Colitis	0.6	0.8	1.2	-0.6	1.1
Blood Red Count	0.6	5.7	9.2	1.5	3.0
Cardiovascular Disease	0.6	2.0	2.4	1.3	1.6
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.4	-0.6	-1.2
Severe depression (siblings)	0.6	0.6	1.2	-0.2	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.0	-1.0	0.8
Had menopause	0.6	0.8	1.2	1.1	-0.6
Pain all over the body in last month	0.6	0.7	1.1	1.1	0.5
Arm fat percentage (right)	0.6	2.4	2.8	1.7	1.4
Arm fat mass (right)	0.6	2.6	3.5	1.9	1.3
Exposure to tobacco smoke outside home	0.6	0.8	1.7	-0.1	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.5	1.2	0.2
Hypertension (Self-reported)	0.6	1.6	1.9	1.2	1.4
Illnesses of siblings: Diabetes	0.6	0.8	1.5	-0.2	1.2
Miserableness	0.6	1.0	1.6	1.3	0.7
Alcohol drinker status: Never	0.6	0.7	0.7	0.9	-0.8
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.0	1.0	-0.6
Fractured/broken bones in last 5 years	0.6	0.8	1.4	1.2	0.5
Myopia	0.6	0.9	1.0	1.0	-0.9
Depressed Affect (Nagel 2018)	0.5	1.0	1.1	1.1	0.9
Schizophrenia vs Biploar Disorder	0.5	0.7	1.0	-0.6	1.0
Blood White Count	0.5	3.5	6.9	2.6	0.1
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	0.8	0.6	0.9
Vitamin and mineral supplements	0.5	0.6	1.2	1.1	-0.4
Serious illness, injury or assault to yourself	0.5	0.6	0.8	-0.7	-0.9
Sitting height	0.5	3.5	4.0	2.0	1.7
High blood pressure (mother)	0.5	0.6	1.3	1.1	-0.0
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	0.8	0.7	-0.9
Weight	0.5	2.4	2.7	1.7	1.4
Impedance of arm (right)	0.5	2.3	4.3	2.1	0.5
Medication: Lansoprazole	0.5	0.5	1.0	1.0	-0.0
Length of working week for main job	0.5	0.6	1.0	-0.4	-1.0
Leg fat percentage (right)	0.5	1.7	2.3	1.1	1.5
Medication: Allopurinol	0.5	0.6	1.1	-0.3	1.1
Heart disease (mother)	0.5	0.6	1.0	0.4	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.7	1.2	-1.1	-0.3
Had major operations	0.5	0.6	0.7	-0.9	-0.7
Family relationship satisfaction	0.5	0.6	1.0	0.4	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.1	0.3	-1.1
Arm fat percentage (left)	0.5	2.0	2.3	1.3	1.5
Ever had bowel cancer screening	0.5	0.6	0.9	0.9	-0.6
Arm fat mass (left)	0.5	2.1	2.4	1.6	1.3
Irritability	0.5	0.9	1.7	0.2	1.3
Risk taking	0.5	0.7	1.1	-0.6	1.0
Leg fat mass (left)	0.5	2.1	2.8	1.2	1.7
Height	0.4	8.3	16.5	4.1	0.4
Hearing difficulty/problems: Yes	0.4	0.6	0.9	1.0	0.6
Age when periods started (menarche)	0.4	1.0	1.3	0.8	-1.2
Multivitamins +/- minerals	0.4	0.5	1.1	-0.1	1.0
Medication: Levothyroxine sodium	0.4	0.7	1.4	1.2	-0.2
Hearing difficulty/problems with background noise	0.4	0.6	1.1	-1.1	-0.3
Mouth/teeth dental problems: Dentures	0.4	0.7	1.4	-0.2	1.2
Mouth/teeth dental problems: Loose teeth	0.4	0.4	0.9	0.9	0.0
Leg fat mass (right)	0.4	1.7	2.1	1.2	1.4
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	0.9	-0.9	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.9	-0.9	0.2
Ever taken oral contraceptive pill	0.4	0.5	1.0	-0.1	-1.0
Mother’s age at death	0.4	0.6	1.1	-0.2	-1.0
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.7	-0.8	0.6
Medication: Blood pressure	0.4	0.8	1.1	1.0	0.7
Basal cell carcinoma (self-reported)	0.4	0.4	0.8	-0.9	-0.1
Heart disease (siblings)	0.4	0.5	1.0	1.0	-0.2
Pack years of smoking	0.4	0.7	1.3	-0.2	1.1
Irritable Bowel Disease (IBD)	0.3	0.6	0.8	-0.9	0.7
Ovarian Cancer	0.3	0.4	0.4	-0.6	0.6
Crohns Disease (2012)	0.3	0.6	1.1	1.0	0.2
Systolic Blood Pressure	0.3	1.4	2.0	1.4	0.9
Lung FVC	0.3	1.8	3.1	1.8	0.6
Chronotype (morning person)	0.3	0.7	0.9	1.0	0.6
Tanning	0.3	4.2	5.6	-1.7	2.4
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.6	-0.4	0.8
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.8	0.9	0.3
Supplements: Glucosamine	0.3	0.4	0.7	0.9	0.1
Waist circumference	0.3	1.2	2.0	0.7	1.4
Forced vital capacity (FVC)	0.3	1.0	1.7	1.3	-0.6
Medication: Ramipril	0.3	0.3	0.4	0.7	0.5
Hip circumference	0.3	1.2	1.3	1.2	1.1
Pulse wave Arterial Stiffness index	0.3	0.3	0.5	0.7	0.4
Impedance of arm (left)	0.3	1.2	1.5	1.2	1.0
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.0	-1.0	0.3
Gout (self-reported)	0.3	0.4	0.5	-0.7	0.7
Medication: Amlodipine	0.3	0.4	0.6	-0.8	-0.4
Forced vital capacity (FVC), Best measure	0.3	1.3	1.8	1.4	0.8
Medication for pain relief, constipation, heartburn	0.3	0.4	0.7	-0.8	-0.4
Neck or shoulder pain in last month	0.3	0.5	0.5	-0.7	0.6
Age at last live birth	0.3	0.4	0.7	-0.8	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	0.6	0.8	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.9	-0.2	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.5	-0.7	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.1	0.3	1.0
Average weekly champagne plus white wine intake	0.3	0.4	0.6	-0.8	0.4
Wears glasses or contact lenses	0.3	0.4	0.7	0.8	0.1
Eye problems/disorders: Glaucoma	0.3	0.3	0.5	-0.3	0.7
Medication: Paracetamol	0.3	0.5	0.8	0.4	0.9
Illnesses of father: High blood pressure	0.3	0.3	0.6	-0.8	-0.1
Crohns Disease (2017)	0.2	0.4	0.8	-0.4	-0.9
HbA1C	0.2	0.2	0.2	0.5	0.5
Neuroticism (2016)	0.2	0.2	0.4	0.7	-0.1
Blood Eosinophil Count	0.2	1.3	2.4	-1.5	-0.5
Relative age of first facial hair	0.2	0.4	0.5	-0.5	-0.7
Leg fat-free mass (left)	0.2	0.9	1.5	1.2	0.6
Relative age voice broke	0.2	0.3	0.7	0.1	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	0.9	-0.2	0.9
Leg predicted mass (left)	0.2	1.1	1.8	1.4	0.6
Nervous feelings	0.2	0.4	0.7	0.4	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.8	0.2	0.9
Heart attack	0.2	0.2	0.3	0.6	0.4
Neuroticism score	0.2	0.5	0.6	-0.6	0.8
Time employed in main current job	0.2	0.3	0.5	-0.7	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.4	0.5	0.6
Hair/balding pattern: Pattern 4	0.2	0.5	0.6	0.8	-0.6
Peak expiratory flow (PEF)	0.2	0.5	1.0	1.0	-0.2
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.4	0.2	-0.6
Headache pain in last month	0.2	0.3	0.4	-0.5	-0.6
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.7	0.8	0.0
Pulse wave peak to peak time	0.2	0.2	0.3	-0.6	-0.2
Medication: Blood pressure	0.2	0.3	0.5	0.7	0.1
Knee pain experienced in last month	0.2	0.4	0.8	0.9	0.0
Smoking status: Previous	0.2	0.3	0.5	-0.3	0.7
Leg fat-free mass (right)	0.2	1.2	1.7	1.3	0.9
Osteoarthritis (self-reported)	0.2	0.3	0.4	0.7	-0.4
Illnesses of father: None of the above (group 1)	0.2	0.2	0.3	-0.6	-0.3
Leg predicted mass (right)	0.2	1.3	1.6	1.3	1.0
High cholesterol (Self-reported)	0.2	0.4	0.6	0.8	0.4
Basal metabolic rate	0.2	1.0	1.8	1.3	0.5
Arm fat-free mass (left)	0.2	1.0	1.9	1.4	0.3
Unable to work because of sickness or disability	0.2	0.3	0.3	-0.5	0.5
Pain experienced in last month	0.2	0.3	0.7	0.1	-0.8
Impedance of whole body	0.2	1.0	1.3	1.1	0.8
Major Depression (MDD)	0.1	0.1	0.2	0.4	0.0
Breast Cancer	0.1	0.1	0.3	0.5	-0.0
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.3	-0.5	-0.2
Blood Platelet Count	0.1	1.6	2.4	-0.9	-1.6
Neuroticism	0.1	0.2	0.3	-0.5	0.4
Hair Pigment	0.1	1.5	1.7	1.3	-1.2
Average weekly spirits intake	0.1	0.2	0.3	0.3	-0.5
Medication: Co-codamol	0.1	0.1	0.3	0.2	0.5
Impedance of leg (right)	0.1	0.3	0.5	0.7	-0.3
Fed-up feelings	0.1	0.2	0.3	0.4	0.6
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	0.5	0.1
Stomach or abdominal pain in last month	0.1	0.1	0.2	0.1	0.5
Body mass index (BMI)	0.1	0.6	1.2	0.2	1.1
Impedance of leg (left)	0.1	0.3	0.4	0.7	0.3
Medication: Simvastatin	0.1	0.1	0.2	0.5	-0.3
Trunk fat-free mass	0.1	0.6	1.3	1.1	-0.1
Alcohol intake versus 10 years previously	0.1	0.1	0.3	0.5	0.1
Pulse rate	0.1	0.2	0.3	-0.0	-0.6
Trunk predicted mass	0.1	0.7	1.4	1.2	-0.1
Tense / ‘highly strung’	0.1	0.2	0.3	-0.2	0.5
Loud music exposure frequency	0.1	0.1	0.2	-0.4	0.1
Medication: Paracetamol	0.1	0.2	0.3	-0.6	-0.2
Arm fat-free mass (right)	0.1	0.6	0.8	0.9	0.5
Comparative body size at age 10	0.1	0.3	0.5	-0.4	0.7
Arm predicted mass (right)	0.1	0.8	0.8	0.8	0.9
Suffer from ‘nerves’	0.1	0.1	0.1	0.3	0.3
Leg pain on walking	0.1	0.1	0.2	-0.2	0.5
Whole body fat-free mass	0.1	0.8	1.5	1.2	0.2
Long-standing illness, disability or infirmity	0.1	0.2	0.2	0.5	-0.3
Whole body water mass	0.1	0.8	1.5	1.2	0.2
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	0.3	0.6
Hearing aid user	0.1	0.1	0.2	0.4	-0.0
Commuting to job workplace: Public transport	0.1	0.1	0.3	0.0	0.5
Medication: Atorvastatin	0.1	0.1	0.2	0.5	0.1
Commuting to job workplace: Cycle	0.1	0.1	0.1	-0.2	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	-0.2	-0.5
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.1	0.4	0.3
Arm predicted mass (left)	0.1	0.7	1.2	1.1	0.4
Neuroticism (Nagel 2018)	0.0	0.1	0.1	0.3	0.2
Worry (Nagel 2018)	0.0	0.1	0.1	0.0	-0.4
BMI	0.0	0.0	0.0	-0.0	0.1
Waist Hip Ratio (WHR)	0.0	0.0	0.0	-0.2	0.0
Hypothyroidism (self reported)	0.0	0.1	0.1	0.4	0.2
Hand grip strength (left)	0.0	0.0	0.0	-0.2	-0.1
Diabetes (father)	0.0	0.0	0.0	0.1	0.1
Hand grip strength (right)	0.0	0.0	0.0	0.0	0.1
Worrier / anxious feelings	0.0	0.0	0.0	0.0	0.1
Happiness	0.0	0.0	0.0	-0.1	-0.1
Depression (self-reported)	0.0	0.0	0.0	-0.2	0.0
Pulse wave reflection index	0.0	0.0	0.0	0.1	-0.2
Health satisfaction	0.0	0.0	0.0	-0.1	-0.2
Medication: Omeprazole	0.0	0.1	0.1	-0.1	-0.3
Loneliness, isolation	0.0	0.0	0.0	-0.1	-0.1
Medication for cholesterol	0.0	0.0	0.1	-0.2	-0.1
Medication: Gliclazide	0.0	0.0	0.0	-0.0	-0.1
Financial situation satisfaction	0.0	0.0	0.1	-0.3	-0.0
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.1	-0.0	0.2
Medication: Lisinopril	0.0	0.0	0.0	-0.2	0.1

Hub : Genes

ALMS1-IT1

Models

Trait associations