TWAS hub - AMDHD2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Lung	0.0834	0.0376	0.0082	-0.003	NA	0.028	NA	-0.001	0.700	NA	0.0032	NA	0.40
2	GTEx	Testis	0.1660	0.0660	0.0026	-0.004	NA	0.014	NA	-0.003	0.550	NA	0.0730	NA	0.44
3	ROSMAP	Brain Pre-frontal Cortex	0.0755	0.0298	0.0021	0.012	0.006	-0.002	0.007	0.003	0.011	0.050	0.7000	0.033	0.10
4	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0720	0.0500	0.0076	0.006	0.021	0.020	NA	0.018	0.140	0.022	0.0240	NA	0.03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Loud music exposure frequency	3.7	4.1	6.7	-1.5	-1.4	-2.4	-2.6
Chronic bronchitis/emphysema (father)	3.1	3.6	9.8	-1.9	-0.0	-3.1	-1.0
Exposure to tobacco smoke outside home	3.1	4.2	7.6	1.0	1.1	2.6	2.8
Leg pain on walking	2.7	3.4	4.3	-1.6	-2.1	-2.0	-1.6
Age at First Birth	2.6	3.7	7.3	1.9	1.8	0.9	2.7
Pain type(s) experienced in last month: Hip pain	2.6	3.3	7.9	-2.8	-0.9	-0.8	-1.9
Height	2.5	47.9	118.8	-4.3	-7.2	1.7	-10.9
Comparative height size at age 10	2.2	12.0	27.2	-2.4	-3.1	2.3	-5.2
Friendships satisfaction	2.2	2.7	6.3	-1.0	-0.7	-2.5	-1.7
Alcohol drinker status: Never	2.2	2.6	5.9	2.4	1.4	-0.2	1.6
Systolic Blood Pressure	2.1	10.8	15.2	-3.9	2.7	-2.7	-3.6
Standing height	2.0	19.5	56.1	-1.7	-3.3	2.8	-7.5
Number of full brothers	2.0	2.5	5.4	-0.4	2.0	0.7	2.3
Heel T-Score	1.9	15.4	31.4	1.9	2.3	-5.6	4.6
Hearing difficulty/problems with background noise	1.9	3.1	4.5	-1.3	-1.4	-2.1	-2.1
Allergy	1.9	4.4	6.7	-2.6	-0.6	-2.6	-2.0
Hip circumference	1.9	8.4	13.4	-3.7	-2.0	-2.5	-3.1
Birth weight of first child	1.9	3.4	9.9	1.2	-0.5	3.1	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	1.9	4.0	8.5	0.2	-0.3	2.7	-2.9
Hearing difficulty/problems: Yes	1.8	2.8	4.9	-2.2	-0.7	-1.8	-1.6
Prospective memory result	1.8	2.2	4.5	-1.4	0.8	-1.3	-2.1
Medication: Seretide 50 evohaler	1.8	2.1	5.0	1.3	1.2	0.5	2.2
Chest pain or discomfort	1.8	2.5	5.8	0.8	1.9	0.2	2.4
Alcohol drinker status: Previous	1.8	2.0	3.0	1.4	1.2	1.7	-1.2
Alzheimer’s Disease (in father)	1.7	1.9	4.6	-1.2	-0.9	-2.1	-0.8
Systolic blood pressure, automated reading	1.7	5.1	10.4	-3.2	1.7	-1.1	-2.4
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	4.9	0.9	2.2	-0.2	1.5
Illnesses of father: High blood pressure	1.7	2.1	6.2	-0.9	0.9	-0.8	-2.5
Ever had prostate specific antigen (PSA) test	1.7	1.9	4.2	2.1	-1.1	1.5	-0.2
Age started oral contraceptive pill	1.7	2.2	3.2	-1.8	1.7	-1.1	-1.1
Cholesterol lowering medication	1.7	2.6	7.0	-1.7	-0.0	-2.6	-0.7
Hayfever/allergic rhinitis (self-reported)	1.6	2.2	4.1	2.0	-0.2	1.6	1.4
Arm fat-free mass (left)	1.6	8.0	21.7	-2.6	-1.8	0.1	-4.7
Depressed Affect (Nagel 2018)	1.5	3.1	7.4	2.7	1.4	1.7	0.1
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.4	9.7	-0.3	1.9	-3.1	0.5
Financial difficulties in last 2 years	1.5	2.0	5.1	0.6	2.3	1.5	0.6
Weight	1.5	7.3	13.7	-3.7	-1.3	-0.7	-3.6
Noisy workplace	1.5	1.9	4.4	-1.1	-0.1	-1.4	-2.1
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	5.0	1.4	0.1	0.2	-2.2
Asthma	1.5	2.9	9.1	0.8	1.0	1.0	3.0
Trunk predicted mass	1.5	8.3	22.4	-1.8	-2.7	0.4	-4.7
Arm fat-free mass (right)	1.5	7.6	19.9	-2.7	-1.8	-0.0	-4.5
Mean time to correctly identify matches	1.5	2.8	5.8	-2.4	-0.9	-0.0	-2.1
Asthma (self-reported)	1.5	3.1	9.4	0.8	1.0	1.1	3.1
Illnesses of father: None of the above (group 1)	1.5	1.8	3.0	1.7	0.8	1.5	1.2
Whole body water mass	1.5	8.5	21.5	-2.5	-2.5	-0.2	-4.6
Basal metabolic rate	1.5	8.1	20.2	-2.8	-2.1	-0.3	-4.5
Depression (Nagel 2018)	1.4	2.1	3.1	1.8	1.7	0.2	1.6
HbA1C	1.4	1.6	3.1	0.5	1.8	-1.7	0.3
Leg fat-free mass (left)	1.4	7.6	16.2	-3.0	-2.1	-0.9	-4.0
Stomach or abdominal pain in last month	1.4	1.8	2.9	1.7	1.6	1.3	0.2
Leg predicted mass (left)	1.4	7.6	16.5	-2.9	-2.1	-0.8	-4.1
Waist circumference	1.4	4.9	14.7	-3.8	-1.0	-0.4	-2.0
Number of incorrect matches in round	1.4	2.3	4.6	1.2	-1.8	2.1	-0.4
Trunk fat-free mass	1.4	8.1	21.5	-1.8	-2.7	0.4	-4.6
Arm predicted mass (right)	1.4	7.0	19.4	-2.4	-1.7	0.2	-4.4
Whole body fat-free mass	1.4	8.3	21.4	-2.4	-2.4	-0.2	-4.6
Arm predicted mass (left)	1.4	7.3	20.1	-2.5	-1.6	0.3	-4.5
Cardiovascular Disease	1.3	4.3	9.9	-2.3	1.0	-3.1	-0.9
Frequency of depressed mood in last 2 weeks	1.3	1.8	5.4	1.1	2.3	-0.6	0.4
Medication: Metformin	1.3	1.8	5.4	-1.2	-2.3	-0.3	0.5
Sitting height	1.3	9.1	28.3	-1.7	-2.1	0.8	-5.3
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.1	5.4	1.5	0.8	0.0	2.3
Hair/balding pattern: Pattern 3	1.3	1.9	3.4	-1.6	0.2	-1.9	-1.3
Length of working week for main job	1.3	1.4	2.0	1.0	1.4	1.4	0.9
Medication: Ventolin 100micrograms inhaler	1.3	1.7	3.9	0.0	0.4	1.6	2.0
Medication: Omeprazole	1.3	1.5	4.2	-1.0	-2.0	-1.0	-0.3
Had major operations	1.3	1.6	2.9	-1.4	-1.0	-1.7	-0.5
Knee pain experienced in last month	1.3	2.1	4.6	-1.6	-2.1	0.5	0.9
Leg fat-free mass (right)	1.3	7.0	15.7	-2.7	-2.0	-0.9	-4.0
Medication for cholesterol	1.3	2.0	4.7	2.2	-0.4	1.7	-0.1
Leg predicted mass (right)	1.3	7.0	15.2	-2.7	-2.1	-0.9	-3.9
Myopia	1.3	1.9	4.0	2.0	0.3	1.1	1.5
Lupus	1.2	1.8	5.3	-0.3	-1.3	-0.4	-2.3
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.6	8.5	-0.0	1.2	-2.9	0.8
Hayfever, allergic rhinitis or eczema	1.2	2.5	5.6	2.4	-0.4	2.1	-0.2
Medication: Levothyroxine sodium	1.2	2.0	4.9	0.9	1.4	2.2	0.6
Depression (self-reported)	1.2	1.4	3.1	-0.9	1.0	-0.8	-1.8
Family relationship satisfaction	1.2	1.5	3.0	-0.7	0.6	-1.7	-1.4
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	3.9	2.0	-0.4	0.8	0.9
Miserableness	1.2	2.1	4.1	2.0	2.0	0.5	0.0
Ever smoked	1.2	2.1	2.9	-1.1	1.3	-1.7	-1.6
Supplements: Calcium	1.2	1.3	4.7	-0.3	-2.2	0.1	0.6
Basal cell carcinoma (self-reported)	1.2	1.4	2.7	0.0	-1.5	0.7	-1.6
Bipolar Disorder (2018)	1.1	1.7	6.2	0.0	-0.8	-2.5	0.1
Crohns Disease (2017)	1.1	2.5	9.0	-0.5	0.2	-0.8	-3.0
Triglycerides	1.1	1.9	3.7	1.7	0.8	-1.9	0.0
Smoking Status	1.1	2.7	6.4	-1.4	-0.4	-1.6	-2.5
Supplements: Glucosamine	1.1	1.4	4.3	0.4	2.1	1.1	-0.0
High blood pressure (mother)	1.1	1.6	3.1	-0.9	1.2	-1.8	-1.1
Trunk fat mass	1.1	4.7	13.6	-3.7	-0.5	-0.1	-2.2
Medication: Simvastatin	1.1	1.6	2.9	-1.7	-0.5	-1.7	-0.8
Medication: Lansoprazole	1.1	1.3	1.8	1.3	1.3	1.3	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.6	6.7	0.3	-1.4	2.6	-2.4
Long-standing illness, disability or infirmity	1.1	1.8	3.7	-1.9	-1.8	0.0	-0.2
Osteoporosis (self-reported)	1.1	1.4	2.5	-0.9	-1.6	-0.3	1.4
Average weekly champagne plus white wine intake	1.1	1.5	3.7	1.9	0.6	1.1	0.7
Guilty feelings	1.1	1.6	4.2	-0.1	1.5	0.3	-2.0
Neuroticism (Nagel 2018)	1.0	2.3	5.9	2.4	1.3	1.2	0.4
Worry (Nagel 2018)	1.0	2.0	2.9	1.7	1.7	0.0	1.5
Reaction Time	1.0	1.9	4.5	-2.1	-0.2	-0.4	-1.6
Prostate Cancer	1.0	1.3	2.4	0.6	1.5	-0.9	1.4
Crohns Disease (2012)	1.0	1.6	3.5	0.0	1.9	-0.8	-1.5
Allergy or Eczema	1.0	2.6	6.7	2.6	-0.2	1.9	0.3
Alcohol usually taken with meals	1.0	1.6	5.2	0.6	-0.3	2.3	-0.8
Arm fat mass (right)	1.0	4.0	11.9	-3.5	-0.7	-0.9	-1.6
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	4.8	0.1	0.6	0.1	2.2
Medication: Ibuprofen	1.0	1.2	2.4	1.6	-0.7	1.4	-0.1
Hypertension (Self-reported)	1.0	2.8	4.8	-2.1	0.8	-2.2	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	3.3	1.1	-0.5	-0.0	1.8
Arm fat mass (left)	1.0	4.0	12.1	-3.5	-0.8	-1.1	-1.4
Medication: Blood pressure	1.0	1.9	6.0	-2.4	-0.2	-1.3	0.2
Diastolic blood pressure, automated reading	1.0	3.1	6.3	-2.5	1.6	-0.3	-1.8
Ever depressed for a whole week	1.0	1.3	2.4	-1.0	-0.5	-1.5	-1.2
Heart disease (siblings)	1.0	1.2	4.2	0.5	2.1	0.7	-0.2
Alzheimer’s Disease (in mother)	0.9	1.1	3.8	0.1	0.6	1.9	-0.4
Primary Biliary Cirrhosis	0.9	1.3	4.4	-0.3	-2.1	-0.7	-0.5
Sensitivity / hurt feelings	0.9	1.5	4.1	-1.0	0.3	-0.9	-2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	2.9	0.7	1.2	-0.2	1.7
High blood pressure	0.9	2.4	4.2	-1.9	1.0	-2.0	-0.9
Past tobacco smoking	0.9	1.7	3.0	1.4	-0.5	1.3	1.7
Had other major operations	0.9	1.1	3.6	0.7	0.5	1.9	0.4
Diabetes (self-reported)	0.9	1.4	4.7	-0.8	0.2	-2.2	0.6
Falls in the last year	0.9	1.2	2.3	0.1	0.7	1.5	1.4
Birth weight	0.9	2.0	3.7	-0.5	-1.2	1.9	-1.6
Chronic bronchitis/emphysema (mother)	0.9	1.0	3.3	-0.7	-1.8	-0.4	0.2
Forced vital capacity (FVC), Best measure	0.9	3.2	6.5	0.2	-1.1	2.2	-2.5
Number of children fathered	0.9	1.1	1.5	-0.5	1.2	-1.1	1.1
Shortness of breath walking on level ground	0.9	1.1	3.6	-0.7	0.5	-1.9	-0.1
Mouth/teeth dental problems: Loose teeth	0.9	1.1	2.4	-1.6	1.4	0.2	0.0
Migraine (self-reported)	0.9	1.2	3.0	-1.2	0.3	-0.4	-1.7
Heart disease (mother)	0.9	1.0	2.7	-0.9	1.6	0.4	-0.7
Whole body fat mass	0.9	3.9	12.1	-3.5	-0.5	-0.3	-1.8
Unable to work because of sickness or disability	0.9	1.1	2.6	-1.6	-0.9	-1.0	-0.1
Hypothyroidism (self reported)	0.8	1.8	4.7	-0.6	0.9	2.2	1.1
Respiratory disease	0.8	1.8	6.5	0.5	0.5	0.3	2.5
Lung FEV1/FVC ratio	0.8	4.0	8.9	-0.6	-3.0	2.5	-0.8
Neuroticism	0.8	1.9	2.9	1.3	1.7	1.7	-0.3
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.2	-0.6	-1.3	-1.5	-0.0
Trunk fat percentage	0.8	3.4	12.3	-3.5	0.3	-0.2	-1.0
Maternal smoking around birth	0.8	1.2	2.6	-0.1	-1.6	-1.4	-0.1
Forced vital capacity (FVC)	0.8	3.2	10.5	-0.1	-0.8	1.4	-3.2
Worrier / anxious feelings	0.8	1.4	3.4	0.5	1.8	-0.3	-1.4
Number of live births	0.8	1.1	3.7	0.7	1.9	-0.5	-0.1
Pulse wave Arterial Stiffness index	0.8	1.0	2.7	-0.5	-1.6	-0.7	-0.6
Peak expiratory flow (PEF)	0.8	1.8	3.1	-1.7	-1.8	0.3	-1.1
Medication: Paracetamol	0.8	1.3	3.6	-0.4	0.7	0.9	-1.9
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	3.6	-0.1	1.0	1.9	1.3
Pulse wave peak to peak time	0.8	1.0	2.9	0.5	1.7	0.9	0.2
Leg fat mass (right)	0.8	3.0	9.4	-3.1	-0.2	-0.5	-1.6
Average weekly red wine intake	0.8	1.1	1.8	0.2	-1.1	1.2	-1.4
Qualifications: nursing, teaching	0.8	1.2	2.8	0.6	-1.0	-1.7	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	5.6	1.0	-0.1	2.4	0.0
Hearing aid user	0.8	0.9	2.2	-1.0	-0.3	1.5	-0.5
Medication: Bendroflumethiazide	0.8	1.1	2.2	-1.5	-0.1	-1.3	-0.8
Irritability	0.8	1.4	3.4	1.8	-0.6	1.3	0.4
Vascular/heart problems diagnosed by doctor	0.8	2.3	4.2	2.0	-1.2	1.7	0.9
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	3.0	-1.0	-1.7	-0.2	0.1
Leg fat mass (left)	0.8	3.1	9.7	-3.1	-0.2	-0.4	-1.5
Verbal and Numeric Reasoning (VNR)	0.7	1.7	5.5	-2.3	-0.2	-1.0	-0.7
Mean Putamen Volume	0.7	0.8	2.9	0.0	0.5	1.7	-0.5
Blood Platelet Count	0.7	7.7	16.7	2.9	2.0	1.3	4.1
Waist Hip Ratio (WHR)	0.7	3.1	11.8	-0.4	0.6	3.4	0.3
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.2	0.4	1.1	-1.0	0.7
Qualifications: CSEs or equivalent	0.7	0.9	1.2	-1.1	-0.7	0.9	1.1
Body mass index (BMI)	0.7	3.1	8.7	-2.9	0.0	-1.9	-0.2
Impedance of leg (left)	0.7	3.4	7.6	1.2	1.9	2.8	0.9
Comparative body size at age 10	0.7	1.8	4.4	-1.0	0.8	-1.2	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.5	1.2	0.9	0.5	0.8
Age at first live birth	0.7	1.2	3.7	0.6	-0.5	0.7	1.9
Health satisfaction	0.7	0.9	2.9	-0.6	0.3	-1.7	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	3.4	0.1	0.3	1.8	-0.2
Number of full sisters	0.7	0.9	2.2	-1.5	-0.7	0.4	-0.9
Overall health rating	0.7	1.5	3.9	-2.0	-0.8	-0.9	-0.7
Smoking status: Previous	0.7	1.1	2.3	-0.9	1.0	-0.5	-1.5
Risk taking	0.7	1.0	1.9	-0.6	0.7	-1.4	-1.0
Intelligence (Savage-Jansen 2018)	0.6	1.9	3.4	-1.9	-0.2	-1.8	-0.9
Ulcerative Colitis (UC)	0.6	1.2	4.4	2.1	0.1	-0.5	0.1
Blood White Count	0.6	4.5	11.1	-2.5	0.6	3.3	-0.7
BMI	0.6	3.5	10.4	-3.2	-0.7	-1.7	0.5
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.0	-0.3	0.1	-1.2	1.7
Chronotype (morning person)	0.6	1.4	2.0	-1.4	-0.9	-1.0	-1.2
Average weekly spirits intake	0.6	0.7	2.4	0.5	-1.6	0.0	-0.5
Impedance of leg (right)	0.6	2.8	7.2	1.1	1.6	2.7	0.6
Townsend deprivation index at recruitment	0.6	0.9	2.3	-1.5	0.3	-0.2	-1.0
Qualifications: None of the above	0.6	1.2	2.9	-1.7	0.4	0.4	-1.2
Pain all over the body in last month	0.6	0.7	2.0	0.5	-0.2	-1.4	0.6
Neuroticism score	0.6	1.2	2.3	1.5	1.5	0.6	-0.0
Forced expiratory volume in 1-second (FEV1)	0.6	2.2	5.5	-0.2	-0.8	1.6	-2.3
Exposure to tobacco smoke at home	0.6	0.7	2.1	-0.6	1.4	0.1	0.6
Tense / ‘highly strung’	0.6	1.0	1.7	-0.4	1.3	-0.8	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.2	-0.7	-0.6	-0.6	-1.5
Gout (self-reported)	0.6	0.9	2.0	0.1	-1.4	-0.7	1.0
Medication: Amlodipine	0.6	0.8	2.0	-0.3	-1.4	-1.1	0.3
Body fat percentage	0.6	2.5	9.7	-3.1	0.3	-0.4	-0.4
Wheeze or whistling in the chest in last year	0.6	1.1	1.5	1.0	1.0	1.0	1.2
Medication: Allopurinol	0.6	0.8	2.2	0.9	0.1	0.6	1.5
Alcohol intake frequency.	0.6	1.3	4.3	0.8	2.1	0.0	0.5
Age at last live birth	0.6	0.9	2.3	0.5	-0.0	0.9	1.5
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.2	0.7	-1.1	-0.8	0.7
Arm fat percentage (left)	0.6	2.6	8.5	-2.9	-0.2	-1.3	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.5	-0.9	1.2	-0.6	-0.1
Back pain experienced in last month	0.6	0.9	1.7	-0.5	-1.0	-0.9	-1.3
Osteoarthritis (self-reported)	0.6	0.8	1.7	0.3	-1.3	1.2	0.0
Financial situation satisfaction	0.6	0.8	1.9	0.0	1.4	-1.1	-0.0
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.6	-0.2	-1.3	-0.8	-0.7
Medication: Paracetamol	0.6	0.9	2.8	0.2	0.1	1.7	-0.9
Fractured/broken bones in last 5 years	0.6	0.8	1.6	-1.3	-0.6	-0.7	0.9
Irritable Bowel Disease (IBD)	0.5	1.1	2.1	1.4	0.0	-0.6	-1.4
HDL Cholesterol	0.5	0.8	2.0	-0.4	-1.4	1.0	0.0
Rheumatoid Arthritis	0.5	0.8	2.8	0.0	0.0	1.7	0.5
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.6	-0.1	-0.3	0.6	1.3
Vitamin and mineral supplements	0.5	0.7	1.8	-0.6	0.7	-0.6	-1.3
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	0.9	-0.8	-0.9	-0.3	-0.9
Multivitamins +/- minerals	0.5	0.7	1.4	1.2	0.2	1.0	0.5
Hair/balding pattern: Pattern 2	0.5	0.6	2.2	0.2	0.2	-0.2	1.5
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.2	-0.3	0.0	0.0	-1.5
Arm fat percentage (right)	0.5	1.9	6.6	-2.6	-0.1	-0.9	0.2
Time employed in main current job	0.5	0.6	2.2	-0.3	-1.5	0.2	-0.0
Father’s age at death	0.5	0.7	1.5	0.3	1.2	-0.9	-0.5
Pulse rate	0.5	0.8	1.9	0.2	-1.1	0.3	1.4
Ever highly irritable/argumentative for 2 days	0.5	0.6	0.8	-0.7	-0.7	-0.7	-0.9
Headache pain in last month	0.5	0.8	2.5	0.8	-0.3	1.6	0.3
Glaucoma (self-reported)	0.5	0.6	1.5	-0.2	0.6	-1.2	-0.6
Leg fat percentage (right)	0.5	1.8	6.6	-2.6	0.7	-0.4	0.0
Medication: Blood pressure	0.5	0.8	1.6	-1.2	0.2	-1.3	-0.3
Breast cancer (self-reported)	0.5	0.6	1.4	0.3	0.7	0.6	1.2
Medication: Atorvastatin	0.5	0.6	2.2	-0.2	1.5	0.2	0.2
Leg fat percentage (left)	0.5	1.8	6.1	-2.5	0.9	-0.4	0.3
Ever had hysterectomy (womb removed)	0.4	0.4	0.7	-0.9	-0.0	-0.6	-0.8
Medication: Co-codamol	0.4	0.5	0.8	-0.9	-0.9	-0.6	0.3
Medication: Atenolol	0.4	0.5	0.9	-0.9	-0.1	-0.5	-0.9
Had menopause	0.4	0.5	1.0	-1.0	1.0	0.4	-0.2
Alcohol intake versus 10 years previously	0.4	0.7	1.4	-0.8	-1.2	0.7	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	1.2	1.1	-0.5	0.8	-0.5
Lung cancer (father)	0.4	0.5	1.1	0.7	0.5	0.4	1.1
Hair/balding pattern: Pattern 4	0.4	1.0	1.9	-1.2	1.4	-0.8	0.4
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.1	0.9	-1.1	0.9	0.2
High blood pressure (siblings)	0.4	0.6	2.1	-0.3	0.2	-1.4	0.0
Eye problems/disorders: None of the above	0.4	0.4	1.3	0.6	0.1	1.1	0.2
Suffer from ‘nerves’	0.4	0.7	2.4	-0.0	0.5	-0.3	1.6
Mood swings	0.4	0.7	1.0	1.0	0.8	0.9	-0.6
Loneliness, isolation	0.4	0.6	1.5	0.8	1.2	-0.6	-0.1
Diabetes diagnosed by doctor	0.4	0.6	1.3	-0.4	0.1	-1.0	1.2
Eye problems/disorders: Cataract	0.4	0.4	0.8	0.3	-0.9	-0.9	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.7	-1.3	-0.4	0.0	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.3	0.5	-0.5	0.2	1.1
Mineral and other dietary supplements	0.4	0.5	0.9	-0.4	-0.3	-0.9	-1.0
Wears glasses or contact lenses	0.4	0.5	0.8	0.9	0.7	0.5	-0.6
Commuting to job workplace: Public transport	0.4	0.5	0.7	-0.6	-0.8	0.7	0.6
Eye problems/disorders: Glaucoma	0.4	0.4	0.9	0.5	0.9	-0.7	-0.3
High cholesterol (Self-reported)	0.4	0.7	1.2	-0.9	-0.8	-1.1	-0.3
Bipolar Disorder or Schizophrenia	0.3	0.8	2.6	0.0	-0.3	-1.6	-0.7
Fasting Glucose	0.3	0.3	0.9	-0.0	0.6	0.1	1.0
Neuroticism (2016)	0.3	0.5	1.5	-0.0	1.2	0.4	0.4
Schizophrenia (2014)	0.3	0.6	1.5	0.0	-0.9	-0.6	-1.2
Angina	0.3	0.4	0.7	0.8	-0.3	0.7	0.4
Diabetes (father)	0.3	0.3	0.6	-0.7	0.3	0.5	-0.6
Taking other prescription medications	0.3	0.5	1.4	-1.2	0.1	0.3	0.6
Age when periods started (menarche)	0.3	0.7	1.6	0.5	0.0	-1.3	-0.9
Medication: Ramipril	0.3	0.3	0.6	-0.8	-0.3	0.0	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	1.1	0.1	0.7	-0.8	1.1
Happiness	0.3	0.4	1.1	0.0	-0.5	-0.4	-1.1
Pulse wave reflection index	0.3	0.3	0.7	-0.2	0.8	0.2	-0.7
Medication for pain relief, constipation, heartburn	0.3	0.5	1.1	-1.1	-0.8	-0.4	-0.1
Angina (self-reported)	0.3	0.4	0.7	0.8	-0.1	0.7	0.6
Medication: Aspirin	0.3	0.4	1.3	0.5	0.3	-1.1	0.2
Mother’s age at death	0.3	0.4	1.0	1.0	-0.7	-0.3	0.3
Medication: Lisinopril	0.3	0.4	0.8	-0.3	0.6	-0.9	-0.5
Average weekly beer plus cider intake	0.3	0.4	1.4	-1.2	-0.1	-0.1	0.4
Impedance of whole body	0.3	1.5	3.1	0.7	1.4	1.8	0.6
Alzheimer’s Disease (including proxy)	0.2	0.3	0.6	-0.5	-0.5	-0.3	-0.8
Breast Cancer	0.2	0.5	1.6	-0.7	-0.2	0.2	-1.3
Ovarian Cancer	0.2	0.3	1.0	-0.3	-0.1	-1.0	0.4
LDL Cholesterol	0.2	0.4	1.3	1.2	-0.1	-0.3	0.0
Hand grip strength (left)	0.2	0.6	1.1	-0.9	-1.0	0.7	-0.5
Relative age of first facial hair	0.2	0.3	0.6	0.8	0.8	0.4	-0.1
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.3	-0.3	-0.5	-0.5	-0.6
Medication for hormone replacement therapy	0.2	0.2	0.5	0.7	-0.1	-0.5	-0.2
Average weekly fortified wine intake	0.2	0.3	0.6	0.3	0.4	0.5	-0.7
Fed-up feelings	0.2	0.4	1.0	1.0	-0.3	-0.5	0.3
Relative age voice broke	0.2	0.4	0.8	-0.0	0.9	0.3	-0.8
Serious illness, injury or assault to yourself	0.2	0.2	0.5	-0.6	-0.1	0.7	0.4
Nervous feelings	0.2	0.4	0.8	0.5	0.6	-0.4	0.9
Mouth/teeth dental problems	0.2	0.4	0.8	0.0	-0.8	0.2	-0.9
Illnesses of siblings	0.2	0.3	0.9	0.2	-0.9	0.5	0.3
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.6	0.1	-0.4	0.3	-1.2
Breastfed as a baby	0.2	0.2	0.6	0.3	-0.4	0.8	-0.2
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.0	1.0	-0.3	0.4	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.8	0.9	-0.1	-0.2	-0.2
Qualifications: College or University degree	0.2	0.6	1.1	0.8	-1.0	0.6	-0.7
Emphysema/chronic bronchitis	0.2	0.2	0.5	-0.3	0.1	0.7	0.5
Neck or shoulder pain in last month	0.2	0.3	0.4	-0.5	0.6	0.1	0.6
Pulse rate, automated reading	0.2	0.7	1.4	-0.4	-0.9	0.5	1.2
Illnesses of father: Heart disease	0.2	0.3	0.6	-0.2	-0.6	0.8	0.1
Illnesses of siblings: Diabetes	0.2	0.2	0.7	0.1	-0.3	0.8	0.3
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.4	0.5	0.7	-0.3	0.2
Ever had bowel cancer screening	0.2	0.3	0.6	0.3	-0.6	0.2	-0.8
Commuting to job workplace: Walk	0.2	0.2	0.3	-0.1	0.4	0.4	-0.6
Medication: Aspirin	0.2	0.3	0.8	-0.1	-0.2	-0.9	-0.4
Ever taken oral contraceptive pill	0.2	0.2	0.8	0.1	0.2	-0.9	0.1
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.6	0.4	-0.1	0.3	0.8
Number of operations (self-reported)	0.2	0.3	1.1	-0.2	-1.0	0.4	0.3
Pain experienced in last month	0.2	0.4	0.7	0.3	0.5	-0.8	0.7
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.5	0.7	-0.0	0.7	0.0
Schizophrenia (2018)	0.1	0.3	0.9	0.0	0.3	-0.2	-1.0
Major Depression (MDD)	0.1	0.1	0.4	0.0	0.0	0.0	-0.7
Blood Eosinophil Count	0.1	0.8	1.8	0.9	-1.4	0.9	0.0
Blood Red Count	0.1	0.8	1.5	-0.7	0.6	-1.2	0.9
Lung FVC	0.1	0.5	0.9	0.7	0.7	0.9	-0.2
Hair Pigment	0.1	2.4	7.1	0.7	0.1	2.7	1.4
Number of treatments/medications taken	0.1	0.2	0.6	-0.4	0.7	0.3	0.1
Diabetes (mother)	0.1	0.2	0.4	0.5	0.1	0.6	0.3
Severe depression (siblings)	0.1	0.1	0.2	0.1	0.1	0.2	-0.5
Hand grip strength (right)	0.1	0.2	0.4	-0.0	-0.4	0.6	-0.5
Heart attack	0.1	0.1	0.2	-0.4	-0.4	0.1	0.4
Impedance of arm (right)	0.1	0.4	0.9	0.5	0.3	1.0	0.5
Medication: Cholesterol lowering	0.1	0.1	0.4	-0.7	0.2	0.0	0.1
Blood clot in the leg (DVT)	0.1	0.2	0.5	0.5	-0.1	0.7	-0.0
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	0.4	-0.1	-0.3	0.2
Medication: Gliclazide	0.1	0.1	0.3	-0.5	-0.0	-0.2	-0.1
Commuting to job workplace: Cycle	0.1	0.1	0.1	-0.2	0.4	-0.4	0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.4	-0.2	-0.4	0.1	0.6
Pack years of smoking	0.1	0.2	0.3	-0.4	0.5	0.4	0.2
Schizophrenia vs Biploar Disorder	0.0	0.1	0.2	0.0	0.0	0.0	-0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.1	0.2	0.0	0.1	0.4	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.0	0.0	0.1	0.0	0.1	0.3	0.3
Tanning	0.0	0.1	0.4	0.6	0.1	-0.1	0.2
Supplements: Zinc	0.0	0.1	0.1	0.3	-0.3	0.1	-0.1
Pack years adult smoking proportion	0.0	0.0	0.1	-0.3	0.2	0.0	0.2
Current tobacco smoking	0.0	0.0	0.1	0.1	-0.2	-0.1	-0.3
Fluid intelligence score	0.0	0.0	0.1	-0.1	0.3	0.2	-0.1
Mouth/teeth dental problems: Dentures	0.0	0.1	0.1	0.4	-0.1	-0.2	0.2
Illnesses of mother	0.0	0.1	0.2	0.0	-0.4	0.0	-0.2
Impedance of arm (left)	0.0	0.2	0.5	-0.1	0.3	0.5	0.7
Worry too long after embarrassment	0.0	0.0	0.1	0.2	0.3	-0.1	0.2
Supplements: Vitamin C	0.0	0.0	0.1	-0.3	-0.1	0.3	0.0
Smoking status: Current	0.0	0.1	0.2	0.1	-0.4	-0.2	-0.2
Number of self-reported non-cancer illnesses	0.0	0.1	0.2	-0.2	0.1	0.5	0.1

Hub : Genes

AMDHD2

Models

Trait associations